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1,215 results on '"Iwaki, Toru"'

203. Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Author

Honda, Hiroyuki, primary, Matsumoto, Masaki, additional, Shijo, Masahiro, additional, Hamasaki, Hideomi, additional, Sadashima, Shoko, additional, Suzuki, Satoshi O, additional, Aishima, Shinichi, additional, Kai, Keita, additional, Nakayama, Keiichi I, additional, Sasagasako, Naokazu, additional, and Iwaki, Toru, additional

Published
2019
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205. MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis

Author

Baba, Toshikazu, primary, Shinoda, Koji, additional, Watanabe, Mitsuru, additional, Sadashima, Shoko, additional, Matsuse, Dai, additional, Isobe, Noriko, additional, Yamasaki, Ryo, additional, Kaneko, Kimihiko, additional, Takahashi, Toshiyuki, additional, Iwaki, Toru, additional, and Kira, Jun-ichi, additional

Published
2019
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207. A Comparative Study of Site-Specific Distribution of Aging-Related Tau Astrogliopathy and Its Risk Factors Between Alzheimer Disease and Cognitive Healthy Brains: The Hisayama Study

Author

Yagita, Kaoru, Honda, Hiroyuki, Ohara, Tomoyuki, Hamasaki, Hideomi, Koyama, Sachiko, Noguchi, Hideko, Mihara, Akane, Nakazawa, Taro, Hata, Jun, Ninomiya, Toshiharu, and Iwaki, Toru

Abstract

Knowledge of aging-related tau astrogliopathy (ARTAG) in healthy elderly individuals remains incomplete and studies to date have not focused on the olfactory nerve, which is a vulnerable site of various neurodegenerative disease pathologies. We performed a semiquantitative evaluation of ARTAG in 110 autopsies in the Japanese general population (Hisayama study). Our analysis focused on Alzheimer disease (AD) and cognitive healthy cases (HC), including primary age-related tauopathy. Among the various diseased and nondiseased brains, ARTAG was frequently observed in the amygdala. The ARTAG of HC was exclusively limited to the amygdala whereas gray matter ARTAG in AD cases was prominent in the putamen and middle frontal gyrus following the amygdala. ARTAG of the olfactory nerve mainly consists of subpial pathology that was milder in the amygdala. A logistic regression analysis revealed that age at death and neurofibrillary tangle Braak stage significantly affected the ARTAG of HC. In AD, age at death and male gender had significant effects on ARTAG. In addition, the Thal phase significantly affected the presence of white matter ARTAG. In conclusion, our research revealed differences in the distribution of ARTAG and affected variables across AD and HC individuals.

Published
2022
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208. Histological background of dedifferentiated solitary fibrous tumour

Author

Yamada, Yuichi, Kohashi, Kenichi, Kinoshita, Izumi, Yamamoto, Hidetaka, Iwasaki, Takeshi, Yoshimoto, Masato, Ishihara, Shin, Toda, Yu, Ito, Yoshihiro, Kuma, Yuki, Yamada-Nozaki, Yui, Koga, Yutaka, Hashisako, Mikiko, Kiyozawa, Daisuke, Kitahara, Daichi, Narutomi, Fumiya, Kuboyama, Yusuke, Nakamura, Takahito, Inoue, Takeshi, Mukai, Munenori, Honda, Yumi, Toyokawa, Gouji, Tsuchihashi, Kenji, Fushimi, Fumiyoshi, Taguchi, Kenichi, Nishiyama, Kenichi, Tamiya, Sadafumi, Oshiro, Yumi, Furue, Masutaka, Nakashima, Yasuharu, Suzuki, Satoshi, Iwaki, Toru, and Oda, Yoshinao

Abstract

AimsDedifferentiation is a histological phenomenon characterised by abrupt transition of histology to a sarcomatous component with high-grade malignant potential in solitary fibrous tumour (SFT). The authors histologically reviewed SFT cases to reveal the histological background of dedifferentiated SFTs.MethodsClinicopathological and histopathological findings of 145 SFT cases were reviewed. Immunohistochemical staining and genetic analysis were also performed.ResultsThe non-dedifferentiated components showed a cellular component in 45 of 145 (31%), high mitotic rate (≥4/10 high-powered field) in 12 of 145 (8.2%) tumours, necrosis in 7 of 145 (4.8%) tumours, multinodular growth pattern in 39 of 132 (29.5%) available tumours and intratumoural fibrous septa in 37 of 131 (28.2%). Immunohistochemically, the non-dedifferentiated components were positive for CD34 in 128 of 141 (90.7%), bcl-2 in 101 of 133 (75.9%), nuclear pattern of β-catenin in 64 of 127 (50.3%) and p16 in 22 of 140 (15.7%). Loss of Rb protein expression was detected in 17 of 110 (15.4%) cases. Statistically, cellular component, multinodular structure, p16 overexpression and Rb protein loss were significantly associated with dedifferentiation. Moreover, cellular component and multinodular structure were significantly associated with p16 overexpression and Rb protein loss. All the non-deddifferentiated components showed wild type of p53 expression. The dedifferentiated components of all 10 dedifferentiated tumours presented positivity for p16 in 9 of 10 (90%) and mutational type of p53 in 5 of 10 (50%). Loss of Rb protein expression was detected in 6 of 10 (60%).ConclusionsThe authors propose that cellular or multinodular transformation may be associated with dedifferentiation. They also suggest that cellular and multinodular transformation may be associated with p16 overexpression and Rb downregulation.

Published
2022
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227. MIB1 staining index and scoring of histologic features in meningioma: indicators for the prediction of biologic potential and postoperative management

Author

Ohta, Masaru, Iwaki, Toru, Kitamoto, Tetsuyuki, Takeshita, Iwao, Tateishi, Jun, and Fukui, Masashi

Subjects
Meningioma -- Prognosis, Tumors -- Identification and classification, Health
Abstract

Background. The biology of brain tumors, including cell kinetics, has been studied. Recently, monoclonal antibody to Ki67 (MIB1), a nuclear protein related to cell proliferation, has been analyzed immunohistochemically using tissue prepared from paraffin embedded sections. Methods. The authors assessed the prognostic usefulness of various histologic indicators of the biologic potential of meningiomas in patients who underwent total resection (Simpson's Grade I and II) by evaluating the time to recurrence as an end point. Forty-three patients with a total of 36 meningiomas and 7 hemangiopericytomas were investigated by immunohistochemical analysis using MIB1. Results. MIB1 staining index (SI) and histologic score were well correlated with the recurrence-free interval (r = -0.6749, P = 0.002 and r = -0.4939, P = 0.027, respectively) and with each other (r = 0.7909, P

Published
1994

228. Preferential expression of alpha-B-crystallin in astrocytic elements of neuroectodermal tumors

Author

Iwaki, Toru, Iwaki, Akiko, Miyazono, Masayuki, and Goldman, James E.

Subjects
Gliomas -- Physiological aspects, Health
Abstract

Abnormal and diseased tissues often contain structures which are not observed in normal tissues. An example is Rosenthal fibers, which are carrot-shaped or beaded structures that can be observed within brain cells under pathological conditions. They may be found in astrocytes that are proliferating in response to an injury, or in astrocytic tumors. Chemical analysis has shown that these Rosenthal fibers are actually made of crystallin, a protein normally found in the lens of the eye. Crystallins can pack together with great efficiency to produce a structure through which light passes readily. The function of these proteins in other tissues remains unknown, however. The observation that the pathological Rosenthal fibers are composed of crystallins has prompted investigators to further study the occurrence of these proteins in brain tumor cells, even tumor cells in which Rosenthal fibers could not be observed. A total of 115 tumor specimens were examined; these specimens covered a wide range of brain tumors. All the tumors, however, shared the common feature of arising from some cell which was neuroectodermal. (This refers to the embryonic origin of the cells which give rise to the tumor; it excludes brain tumors such as meningiomas and metastatic brain tumors.) The researchers found that crystallins were commonly present in tumor cells that arose from astrocytes in the brain. Tumors such as ependymoma, which arise from other cells, contained few or no crystallins. Furthermore, in some tumors involving a mixture of cell types, only the astrocytic elements of the tumor were found to contain crystallins. Various types of gliomas that are predominantly astrocytic, such as anaplastic astrocytoma and glioblastoma multiforme, often contained much crystallin. These results indicate that crystallins are a common component of tumors with astrocytic components, regardless of whether the tumor contains Rosenthal fibers or not. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

231. A juvenile case of epilepsy‐associated, isocitrate dehydrogenase wild‐type/histone 3 wild‐type diffuse glioma with a rare BRAFA598T mutation.

Author

Sadashima, Shoko, Suzuki, Satoshi O., Haruyama, Hironori, Mukae, Nobutaka, Fujioka, Yutaka, Hata, Nobuhiro, Mizoguchi, Masahiro, Ishimatsu, Keisuke, Hiwatashi, Akio, and Iwaki, Toru

Subjects
ISOCITRATE dehydrogenase, EXTRACELLULAR signal-regulated kinases, CENTRAL nervous system tumors, MALATE dehydrogenase, GLIOMAS, MITOGEN-activated protein kinases, TEMPORAL lobe epilepsy
Abstract

Here, we report a juvenile (18‐year‐old male) case of epilepsy‐associated, isocitrate dehydrogenase wild‐type/histone 3 wild‐type diffuse glioma with a rare BRAF mutation and a focal atypical feature resembling diffuse astrocytoma. The patient presented with refractory temporal lobe epilepsy. Subsequently, magnetic resonance imaging revealed a hyperintense lesion in the right temporal lobe on fluid attenuated inversion recovery images. The patient underwent right lateral temporal lobectomy and amygdalohippocampectomy. Histopathologically, the tumor showed isomorphic, diffuse, infiltrative proliferation of glial tumor cells and intense CD34 immunoreactivity. The tumor cells were immunonegative for isocitrate dehydrogenase 1 (IDH1) R132H and BRAF V600E. Notably, the tumor cells showed the lack of nuclear staining for α‐thalassemia/mental retardation syndrome, X‐linked (ATRX). In addition, the Ki‐67 labeling index, using a monoclonal antibody MIB‐1, was elevated focally at tumor cells with p53 immunoreactivity. Molecular analyses identified a BRAFA598T mutation, the first case reported in a glioma. BRAFA598T is predicted to result in loss of kinase action; however, inactive mutants can stimulate mitogen‐activated protein kinase kinase (MEK)‐extracellular signal‐regulated kinase (ERK) signaling through CRAF activation. Thus, according to the recent update of the consortium to inform molecular and practical approaches to central nervous system tumor taxonomy (cIMPACT‐NOW update 4), our case is also compatible with diffuse glioma with the mitogen‐activated protein kinase (MAPK) pathway alteration. Thorough immunohistochemical and molecular studies are necessary for diagnosis of epilepsy‐associated, diffuse gliomas. Partial resemblance in histopathological and molecular genetic features to diffuse astrocytoma also calls for attention. [ABSTRACT FROM AUTHOR]

Published
2020
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232. A case of overlapping adult‐onset linear scleroderma and Parry‐Romberg syndrome presenting with widespread ipsilateral neurogenic involvement.

Author

Yamasaki, Ryo, Yonekawa, Tomomi, Inamizu, Saeko, Shinoda, Koji, Ochi, Hirofumi, Matsushita, Takuya, Isobe, Noriko, Tsuji, Gaku, Sadashima, Shoko, Kuma, Yuki, Oda, Yoshinao, Iwaki, Toru, Furue, Masutaka, and Kira, Jun‐ichi

Subjects
QUADRICEPS muscle, MAGNETIC resonance imaging, BLEPHAROPTOSIS, SKIN biopsy, FACIOSCAPULOHUMERAL muscular dystrophy, SYNDROMES, NEMALINE myopathy
Abstract

Linear scleroderma is a variant of localized scleroderma. We report a 43‐year‐old woman who had developed left arm weakness and linear scleroderma on her back during pregnancy at 25 years of age, followed by left hemifacial atrophy and left leg weakness. She had multiple linear scleroderma lesions on her trunk and left limbs, left eyelid ptosis, impairment of vertical movement and abduction of the left eye, left hemifacial atrophy, and weakness and atrophy of the sternocleidomastoid, trapezius, and proximal limb muscles on the left side. On serology, antibodies to U1‐ribonucleoprotein and Jo‐1 were positive; anti‐scleroderma‐70 antibody was negative. Skin biopsy demonstrated increased hypertrophic collagen fibers without inflammatory infiltrates. Needle electromyography of left limb muscles revealed mild neurogenic patterns; left quadriceps muscle biopsy showed chronic neurogenic changes. Brain magnetic resonance imaging revealed mild left hemispheric atrophy. This is a rare case of linear scleroderma and Parry–Romberg syndrome presenting with widespread ipsilateral neurogenic manifestations. [ABSTRACT FROM AUTHOR]

Published
2020
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233. Dynactin is involved in Lewy body pathology

Author

Shen, Chang, primary, Honda, Hiroyuki, additional, Suzuki, Satoshi O, additional, Maeda, Norihisa, additional, Shijo, Masahiro, additional, Hamasaki, Hideomi, additional, Sasagasako, Naokazu, additional, Fujii, Naoki, additional, and Iwaki, Toru, additional

Published
2018
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236. Radiological Features of Brain Metastases from Non-small Cell Lung Cancer HarboringEGFRMutation

Author

TAKAMORI, SHINKICHI, primary, TOYOKAWA, GOUJI, additional, SHIMOKAWA, MOTOTSUGU, additional, KINOSHITA, FUMIHIKO, additional, KOZUMA, YUKA, additional, MATSUBARA, TAICHI, additional, HARATAKE, NAOKI, additional, AKAMINE, TAKAKI, additional, MUKAE, NOBUTAKA, additional, HIRAI, FUMIHIKO, additional, TAGAWA, TETSUZO, additional, ODA, YOSHINAO, additional, IWAKI, TORU, additional, IIHARA, KOJI, additional, HONDA, HIROSHI, additional, and MAEHARA, YOSHIHIKO, additional

Published
2018
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240. Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging: validation with histopathological vascular density in meningiomas

Author

Togao, Osamu, primary, Hiwatashi, Akio, additional, Yamashita, Koji, additional, Kikuchi, Kazufumi, additional, Momosaka, Daichi, additional, Yoshimoto, Koji, additional, Kuga, Daisuke, additional, Mizoguchi, Masahiro, additional, Suzuki, Satoshi O, additional, Iwaki, Toru, additional, Van Cauteren, Marc, additional, Iihara, Koji, additional, and Honda, Hiroshi, additional

Published
2018
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242. Correlation between particle size/domain structure and magnetic properties of highly crystalline Fe3O4 nanoparticles

Author

Li, Qing, Kartikowati, Christina W., Horie, Shinji, Ogi, Takasi, Iwaki, Toru, Okuyama, Kikuo, Li, Qing, Kartikowati, Christina W., Horie, Shinji, Ogi, Takasi, Iwaki, Toru, and Okuyama, Kikuo

Abstract

type:text, Highly crystalline single-domain magnetite Fe3O4 nanoparticles (NPs) are important, not only for fundamental understanding of magnetic behaviour, but also for their considerable potential applications in biomedicine and industry. Fe3O4 NPs with sizes of 10–300 nm were systematically investigated to reveal the fundamental relationship between the crystal domain structure and the magnetic properties. The examined Fe3O4 NPs were prepared under well-controlled crystal growth conditions using a large-scale liquid precipitation method. The crystallite size of cube-like NPs estimated from X-ray diffraction pattern increased linearly as the particle size (estimated by transmission electron microscopy) increased from 10 to 64.7 nm, which indicates that the NPs have a single-domain structure. This was further confirmed by the uniform lattice fringes. The critical size of approximately 76 nm was obtained by correlating particle size with both crystallite size and magnetic coercivity; this was reported for the first time in this study. The coercivity of cube-like Fe3O4 NPs increased to a maximum of 190 Oe at the critical size, which suggests strong exchange interactions during spin alignment. Compared with cube-like NPs, sphere-like NPs have lower magnetic coercivity and remanence values, which is caused by the different orientations of their polycrystalline structure., This work was supported by JSPS KAKENHI Grant Number 26709061 and 16K13642. This work was partly supported by the Center for Functional Nano Oxide at Hiroshima University. The authors also gratefully acknowledge the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan for providing scholarships (C. W. K.).

Published
2017

243. Early and extensive spinal white matter involvement in neuromyelitis optica

Author

Hayashida, Shotaro, Masaki, Katsuhisa, Yonekawa, Tomomi, Suzuki, Satoshi O., Hiwatashi, Akio, Matsushita, Takuya, Watanabe, Mitsuru, Yamasaki, Ryo, Suenaga, Toshihiko, Iwaki, Toru, Murai, Hiroyuki, Kira, Jun-ichi, 小田, 義直, 園田, 康平, and 新納, 宏昭

Subjects
Adult, Aquaporin 4, Male, Time Factors, Neuromyelitis Optica, Middle Aged, Immunohistochemistry, Magnetic Resonance Imaging, White Matter, HEK293 Cells, Spinal Cord, Disease Progression, Humans, Female, Gray Matter, Research Articles, Aged, Autoantibodies
Abstract

OBJECTIVES: Studies of longitudinally extensive spinal cord lesions (LESCLs) in neuromyelitis optica (NMO) have focused on gray matter, where the relevant antigen, aquaporin‐4 (AQP4), is abundant. Because spinal white matter pathology in NMO is not well characterized, we aimed to clarify spinal white matter pathology of LESCLs in NMO. METHODS: We analyzed 50 spinal cord lesions from eleven autopsied NMO/NMO spectrum disorder (NMOSD) cases. We also evaluated LESCLs with three or fewer spinal cord attacks by 3‐tesla MRI in 15 AQP4 antibody‐positive NMO/NMOSD patients and in 15 AQP4 antibody‐negative multiple sclerosis (MS) patients. RESULTS: Pathological analysis revealed seven cases of AQP4 loss and four predominantly demyelinating cases. Forty‐four lesions from AQP4 loss cases involved significantly more frequently posterior columns (PC) and lateral columns (LC) than anterior columns (AC) (59.1%, 63.6%, and 34.1%, respectively). The posterior horn (PH), central portion (CP), and anterior horn (AH) were similarly affected (38.6%, 36.4% and 31.8%, respectively). Isolated perivascular inflammatory lesions with selective loss of astrocyte endfoot proteins, AQP4 and connexin 43, were present only in white matter and were more frequent in PC and LC than in AC (22.7%, 29.5% and 2.3%, P (corr) = 0.020, and P (corr) = 0.004, respectively). MRI indicated LESCLs more frequently affected PC and LC than AC in anti‐AQP4 antibody‐seropositive NMO/NMOSD (86.7%, 60.0% and 20.0%, P (corr) = 0.005, and P (corr) = 0.043, respectively) and AQP4 antibody‐seronegative MS patients (86.7%, 73.3% and 33.3%, P (corr) = 0.063, and P (corr) = 0.043, respectively). PH, CP and AH were involved in 93.3%, 86.7% and 73.3% of seropositive patients, respectively, and in 53.3%, 60.0% and 40.0% of seronegative patients, respectively. CONCLUSIONS: NMO frequently and extensively affects spinal white matter in addition to central gray matter, especially in PC and LC, where isolated perivascular lesions with astrocyte endfoot protein loss may emerge. Spinal white matter involvement may also appear in early NMO, similar to cerebral white matter lesions.

Published
2016

245. High-resolution melting and immunohistochemical analysis efficiently detects mutually exclusive genetic alterations of adamantinomatous and papillary craniopharyngiomas

Author

Yoshimoto, Koji, primary, Hatae, Ryusuke, additional, Suzuki, Satoshi O., additional, Hata, Nobuhiro, additional, Kuga, Daisuke, additional, Akagi, Yojiro, additional, Amemiya, Takeo, additional, Sangatsuda, Yuhei, additional, Mukae, Nobutaka, additional, Mizoguchi, Masahiro, additional, Iwaki, Toru, additional, and Iihara, Koji, additional

Published
2017
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250. A Case of Suprasellar Ganglioglioma arising from the Genu-Rostrum of the Corpus Callosum composed of Tumor Cells in Various Stages of Neuronal Differentiation

Author

Funakoshi, Yusuke, primary, Natori, Yoshihiro, additional, Suzuki, Satoshi, additional, Iwaki, Toru, additional, Imamoto, Naoyuki, additional, Yamada, Tetsuhisa, additional, Inoue, Daisuke, additional, Mori, Megumu, additional, Matsuo, Satoshi, additional, and Iwaki, Katsuma, additional

Published
2017
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