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208. Therapeutic Arteriogenesis by Fibrin Based Delivery Of Engineered VEGF and PDGF-BB Accelerates Diabetic Wound Healing in a Mouse Model

Author

D'Amico, Rosalinda, primary, Malucelli, Camilla, additional, Uccelli, Andrea, additional, Grosso, Andrea, additional, Di Maggio, Nunzia, additional, Gürke, Lorenz, additional, Wolff, Thomas, additional, Mujagic, Edin, additional, Briquez, Priscilla S., additional, Hubbell, Jeffrey A., additional, Gianni-Barrera, Roberto, additional, and Banfi, Andrea, additional

Published
2020
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209. CONTRIBUTORS

Author

Ahlstrom, Jon D., primary, Altschuler, Richard A., additional, Amendola, A., additional, Anderson, David J., additional, Anversa, Piero, additional, Atala, Anthony, additional, Athanasiou, Kyriacos A., additional, Auger, François A., additional, Auguste, Debra T., additional, Bearzi, Claudia, additional, Becker, Daniel, additional, Bedoya, Francisco J., additional, Bell, Eugene, additional, Bertram, Timothy, additional, Besnard, Valérie, additional, Bettinger, Christopher J., additional, Bhatia, Sangeeta N., additional, Bianco, Paolo, additional, Bishop, Anne E., additional, Blackburn, C. Clare, additional, Bohrer, Michael P., additional, Bolli, Roberto, additional, Bonassar, Lawrence J., additional, Borenstein, Jeffrey T., additional, Boulton, Michael E., additional, Bradshaw, Amy D., additional, Brewster, Luke, additional, Brey, Eric M., additional, Brittan, Mairi, additional, Brown, T., additional, Bruder, Scott P., additional, Buckwalter, Joseph A., additional, Cannizzaro, Christopher, additional, Cao, Yilin, additional, Cathey, Lamont, additional, Chang, Thomas M.S., additional, Chang, Yunchao, additional, Chapman, Robert G., additional, Chen, Alice A., additional, Chen, Faye H., additional, Chen, Una, additional, Clark, Richard A.F., additional, Colton, Clark K., additional, Cowin, Stephen C., additional, Crystal, Ronald, additional, Dagnelie, Gislin, additional, Davidson, Jeffrey M., additional, Deuel, Thomas F., additional, Deweerd, Elizabeth, additional, Dressler, Gregory R., additional, Engelmayr, George C., additional, Erickson, Carol A., additional, Eschenhagen, Thomas, additional, Falanga, Vincent, additional, Faria, Katie, additional, Faustman, Denise L., additional, Fauza, Dario O., additional, Ferreira, Lino da Silva, additional, Fong, Hanson K., additional, Fong, Peter, additional, Freed, Lisa E., additional, Freshney, R.I., additional, Furth, Mark E., additional, Geesin, Jeffrey, additional, Gerecht, Sharon, additional, Germain, Lucie, additional, Ghosh, Kaustabh, additional, Giannobile, William V., additional, Goulet, Francine, additional, Grant, Maria B., additional, Grayson, Warren, additional, Greisler, Howard P., additional, Guilak, Farshid, additional, Halberstadt, Craig, additional, Harley, Brendan, additional, Hellman, Kiki B., additional, Hmadcha, Abdelkrim, additional, Hodges, Steve J., additional, Holder, Walter D., additional, Holy, Chantal E., additional, Hosoda, Toru, additional, Hubbell, Jeffrey A., additional, Humes, H. David, additional, Ingber, Donald E., additional, Jaklenec, Ana, additional, Jun, Hee-Sook, additional, Kajstura, Jan, additional, Kane, Ravi S., additional, Karp, Jeffrey M., additional, Kay, John, additional, Khademhosseini, Ali, additional, Khetani, Salman R., additional, Kohn, Joachim, additional, Kunisaki, Shaun M., additional, Kwan, Matthew D., additional, Kyriakides, Themis R., additional, Lagasse, Eric, additional, Langer, Robert, additional, Lauffenburger, Douglas A., additional, Yong Lee, Kuen, additional, Leri, Annarosa, additional, Levine, David W., additional, Lewis, Amy S., additional, Li, Wan-Ju, additional, Liu, Wei, additional, Longaker, Michael T., additional, Luo, Ying, additional, Lysaght, Michael J., additional, Manley, Nancy Ruth, additional, Mansbridge, Jonathan, additional, Marsh, J.L., additional, Martin, David C., additional, Martin, J.A., additional, Martins-Green, Manuela, additional, Masuda, Koichi, additional, Mauck, Robert L., additional, McDonald, John W., additional, Mikos, Antonios G., additional, Miller, Josef M., additional, Mooney, David J., additional, Moore, Malcolm A.S., additional, Murphy, Matthew B., additional, Nerem, Robert M., additional, Nikovits, William, additional, Nowell, Craig Scott, additional, Obradovic, Bojana, additional, Olsen, Bjorn R., additional, Pachence, James M., additional, Park, Hyoungshin, additional, Park, Jason, additional, Petreaca, M., additional, Polak, Julia M., additional, Poole, A. Robin, additional, Potten, Christopher S., additional, Prokop, Ales, additional, Radisic, Milica, additional, Raphael, Yehoash, additional, Reddi, A. Hari, additional, Reichenspurner, Herrmann, additional, Richie, Ellen, additional, Robey, Pamela G., additional, Rota, Marcello, additional, Ruberti, Jeffrey W., additional, Russell, Alan J., additional, Sage, E. Helene, additional, Saigal, Rajiv, additional, Saltzman, W. Mark, additional, Sambanis, Athanassios, additional, Schacht, Jochen, additional, Setton, Lori A., additional, Sharma, Upma, additional, Sharpe, Paul T., additional, Slack, Jonathan M.W., additional, Smith, Anthony J., additional, Somerman, Martha J., additional, Song, Lin, additional, Soria, Bernat, additional, Stockdale, Frank E., additional, Studer, Lorenz, additional, Takayama, Shuichi, additional, Tejedo, Juan R., additional, Trinkaus-Randall, Vickery, additional, Trounson, Alan, additional, Tuan, Rocky S., additional, Underhill, Gregory H., additional, Urbanek, Konrad, additional, Vacanti, Charles A., additional, Vacanti, Joseph, additional, Volenec, F. Jerry, additional, Vunjak-Novakovic, Gordana, additional, Wahlberg, Lars U., additional, Wan, Derrick C., additional, Whitesides, George M., additional, Whitsett, Jeffrey A., additional, Wilson, James W., additional, Worgall, Stefan, additional, Wong, Mark E.K., additional, Wright, Nicholas A., additional, Yannas, Ioannis V., additional, Yoon, Ji-Won, additional, Young, Simon, additional, Zhang, Hai, additional, Zhang, Wenjie, additional, Zielinski, Beth A., additional, Zieske, James D., additional, Zimmermann, Wolfram-Hubertus, additional, and Zoloth, Laurie, additional

Published
2007
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218. Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy

Author

Sasaki, Koichi, Ishihara, Jun, Ishihara, Ako, Miura, Risako, Mansurov, Aslan, Fukunaga, Kazuto, and Hubbell, Jeffrey A.

Subjects
Programmed Cell Death 1 Receptor, Serum albumin, Antineoplastic Agents, Aldoxorubicin, Vascular permeability, 02 engineering and technology, Mice, 03 medical and health sciences, Protein Domains, Von Willebrand factor, Cell Line, Tumor, von Willebrand Factor, medicine, Animals, Doxorubicin, Cytotoxicity, Research Articles, Serum Albumin, Cancer, 030304 developmental biology, Drug Carriers, 0303 health sciences, Multidisciplinary, biology, Chemistry, Hydrazones, SciAdv r-articles, 021001 nanoscience & nanotechnology, digestive system diseases, Extravasation, 3. Good health, Mice, Inbred C57BL, Colonic Neoplasms, biology.protein, Cancer research, Female, 0210 nano-technology, Research Article, medicine.drug, Conjugate
Abstract

Collagen-binding ability improves serum albumin as an anti-cancer drug carrier, resulting in enhanced therapeutic efficacy., Serum albumin (SA) is used as a carrier to deliver cytotoxic agents to tumors via passive targeting. To further improve SA’s tumor targeting capacity, we sought to develop an approach to retain SA-drug conjugates within tumors through a combination of passive and active targeting. SA was recombinantly fused with a collagen-binding domain (CBD) of von Willebrand factor to bind within the tumor stroma after extravasation due to tumor vascular permeability. Doxorubicin (Dox) was conjugated to the CBD-SA via a pH-sensitive linker. Dox-CBD-SA treatment significantly suppressed tumor growth compared to both Dox-SA and aldoxorubicin treatment in a mouse model of breast cancer. Dox-CBD-SA efficiently stimulated host antitumor immunity, resulting in the complete eradication of MC38 colon carcinoma when used in combination with anti–PD-1 checkpoint inhibitor. Dox-CBD-SA decreased adverse events compared to aldoxorubicin. Thus, engineered CBD-SA could be a versatile and clinically relevant drug conjugate carrier protein for treatment of solid tumors.

Published
2019
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219. MOESM1 of Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis

Author

Katsumata, Kiyomitsu, Ishihara, Jun, Fukunaga, Kazuto, Ako Ishihara, Yuba, Eiji, Budina, Erica, and Hubbell, Jeffrey

Abstract

Additional file 1: Figure S1. Retention of PlGF-2123-144-α-TNF at the injected paw of athymic nude mice. Figure S2. Effect of PlGF-2123-144 peptide locally injected around joints of the CAIA model. Figure S3. Changes in plasma concentrations after local injection to CAIA mice.

Published
2019
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228. CONTRIBUTORS

Author

Aebischer, Patrick, primary, Altschuler, Richard A., additional, Ambrosini, Pascal, additional, Anderson, David J., additional, Atala, Anthony, additional, Auger, François A., additional, Avgoustiniatos, Efstathios S., additional, Barnes, David W., additional, Bell, Eugene, additional, Béné, Marie C., additional, Bishop, John G., additional, Bohrer, T., additional, Bonassar, Lawrence J., additional, Bradshaw, Amy D., additional, Brockbank, Kelvin G.M., additional, Browder, Leon W., additional, Bruder, Scott P., additional, Bunge, Mary Bartlett, additional, Caplan, Arnold I., additional, Chang, Thomas Ming Swi, additional, Chapman, Robert G., additional, Chen, Una, additional, Clark, Richard A.F., additional, Cloutier, Réjean, additional, Colton, Clark K., additional, Cousins, Joanne C., additional, Cowin, Stephen C., additional, Dagnelie, Gislin, additional, Deuel, Thomas F., additional, Durfor, Charles N., additional, Edwards, Brian E., additional, Erickson, Carol A., additional, Faure, Gilbert C., additional, Faustman, Denise, additional, Fauza, Dario O., additional, Fine, Eric G., additional, Fradkin, Lee G., additional, Freed, Lisa E., additional, Gaffey, Claudia, additional, Gearhart, John D., additional, Germain, Lucie, additional, Goulet, Francine, additional, Greisler, Howard P., additional, Grodzinsky, Alan J., additional, Halberstadt, Craig R., additional, Hardin-Young, Janet, additional, Hasse, C., additional, Hebrok, Matthias, additional, Hellman, Kiki B., additional, Holder, Walter D., additional, Hsu, Edward, additional, Hubbell, Jeffrey A., additional, Humayun, Mark S., additional, Humes, H. David, additional, Ingber, Donald E., additional, Jauregui, Hugo O., additional, Kamm, Roger D., additional, Kane, Ravi S., additional, Karlsson, Jens O.M., additional, Kessinger, Anne, additional, Kim, Byung-Soo, additional, Kleitman, Naomi, additional, Kohn, Joachim, additional, Kubota, Hiroshi, additional, Lanza, Robert P., additional, Lauffenburger, Douglas A., additional, Lee, Kuen Yong, additional, Lelkes, Peter I., additional, London, Robert E., additional, Love, Jack W., additional, Luntz, Thomas L., additional, Lysaght, Michael J., additional, Macdonald, Jeffrey M., additional, Martins-Green, Manuela, additional, Massof, Robert W., additional, McPherson, John M., additional, Melton, Douglas A., additional, Mikos, Antonios G., additional, Miller, Josef M., additional, Miller, Neal A., additional, Mooney, David J., additional, Morgan, Jennifer E., additional, Moss, Melvin L., additional, Mullon, Claudy, additional, Muratore, Christopher S., additional, Naughton, Gail K., additional, Nerem, Robert M., additional, Olsen, Björn Reino, additional, Organ, Gregory M., additional, Pachence, James M., additional, Parenteau, Nancy L., additional, Partridge, Terence A., additional, Penaud, Jacques, additional, Poole, A. Robin, additional, Rancourt, Denis, additional, Raphael, Yehoash, additional, Reddi, A.H., additional, Reid, Lola M., additional, Ropp, J. Dezz, additional, Ross, Robert N., additional, Rothmund, M., additional, Rutherford, R. Bruce, additional, Sage, E. Helene, additional, Sagen, Jacqueline, additional, Saltzman, W. Mark, additional, Sato, Gordon H., additional, Schacht, Jochen, additional, Shamblott, Michael J., additional, Sharp, Graham, additional, Shung, Albert K., additional, Singer, Adam J., additional, Solomon, Barry A., additional, Solomon, Ruth R., additional, Sullivan, Susan J., additional, Takayama, Shuichi, additional, Teumer, Jeffrey, additional, Thomson, Robert C., additional, Toner, Mehmet, additional, Trinkaus-Randall, Vickery, additional, Tubo, Ross, additional, Unsworth, Brian R., additional, Vacanti, Charles A., additional, Vacanti, Joseph P., additional, Vacanti, Martin P., additional, Valentini, Robert F., additional, Vunjak-Novakovic, Gordana, additional, Wahlberg, Lars U., additional, Wang, Taylor G., additional, Warner, John F., additional, Whitesides, George M., additional, Wilson, Jay M., additional, Wu, Haiyun, additional, Xu, Arron S.L., additional, Xue, Lian, additional, Yannas, Ioannis V., additional, Yaszemski, Michael J., additional, Zhang, Nan, additional, Zielinski, Beth A., additional, Zielke, A., additional, and Zimmerman, U., additional

Published
2000
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237. Design, characterization, and one-point in vivo calibration of a subcutaneously implanted glucose electrode

Author

Csoregi, Elisabeth, Quinn, Chris P., Schmidtke, David W., Lindquist, Sten-Eric, Pishko, Michael V., Ye, Ling, Katakis, Ioanis, Hubbell, Jeffrey A., and Heller, Adam

Subjects
Glucose -- Research, Electrolysis -- Research, Chemistry
Abstract

A 0.29-mm-diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode was designed to allow 'one-point' in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. A valid zero point, along with a measurement of the glucose concentration in a withdrawn sample of blood at which the current is known, defined the sensitivity in the linear response range. The electrode was four-layered, with the layers serially deposited within a 0.125-mm recess upon the tip of a polyimide-insulated 0.25-mm gold wire. The recessed structure reduced the sensitivity to movement and allowed, through control of the depth of the recess, control of the transport of glucose and thus the range of linearity. The recess contained the four polymeric layers, with a total mass less than 5 [[micro]gram] and no leachable components. The bottom glucose concentration-to-current transducing layer consisted of the enzyme 'wiring' redox polymer [poly[(vinylimidazole)Os[(bipyridine).sub.2]Cl].sup.+/2+], complexed with recombinant glucose oxidase and cross-linked with poly (allylamine), on which an immobilized interference-eliminating horseradish peroxidase based film was deposited. An outer biocompatible layer was formed by photo-cross-linked poly(allylamine), on which an immobilized interference-eliminating horseradish peroxidase based film was deposited. An outer biocompatible layer was formed by photo-cross-linking derivatized poly(ethylene oxide). The current output of a typical electrode at 10 mM, glucose and at 37 [degrees] C was 35 nA, the apparent [K.sub.m] was 20 mM, and the 10-90% response time was [approximately] 1 min. The sensitivity varied only by [+ or -] 5% over a 72-h test period. The electrode tracked the blood glucose concentration in a rat model before, during, and following intraperitoneal glucose infusion. Two failure modes were observed. The first, deactivation of hydrogen peroxide-producing lactate oxidase in the interference-eliminating layer, resulted in inadequate preoxidation of interferants. The second was an abrupt drop in the sensitivity of implanted electrodes, [approximately] 7 h after implantation. The failed electrodes promptly regained their sensitivity in buffer.

Published
1994

241. Classes of Materials Used in Medicine

Author

Abramson, Sascha, primary, Alexander, Harold, additional, Best, Serena, additional, Bokros, J.C., additional, Brunski, John B., additional, Colas, André, additional, Cooper, Stuart L., additional, Curtis, Jim, additional, Haubold, Axel, additional, Hench, Larry L., additional, Hergenrother, Robert W., additional, Hoffman, Allan S., additional, Hubbell, Jeffrey A., additional, Jansen, John A., additional, King, Martin W., additional, Kohn, Joachim, additional, Lamba, Nina M.K., additional, Langer, Robert, additional, Migliaresi, Claudio, additional, More, Robert B., additional, Peppas, Nicholas A., additional, Ratner, Buddy D., additional, Visser, Susan A., additional, Recum, Andreas von, additional, Weinberg, Steven, additional, and Yannas, Ioannis V., additional

Published
1996
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250. Abstract 1553: Collagen affinity improves safety and efficacy of antibody and cytokine cancer immunotherapies

Author

Ishihara, Jun, primary, Ishihara, Ako, additional, Mansurov, Aslan, additional, Sasaki, Koichi, additional, Lee, Steve S., additional, Williford, John-Michael, additional, Potin, Lambert, additional, Hosseinchi, Peyman, additional, Gray, Laura T., additional, Katsumata, Kiyomitsu, additional, Kron, Stephen J., additional, Swartz, Melody A., additional, and Hubbell, Jeffrey A., additional

Published
2019
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