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962 results on '"Higgs, D"'

230. High resolution gene mapping of the human alpha globin locus.

Author

Nicholls, R D, Jonasson, J A, McGee, J O, Patil, S, Ionasescu, V V, Weatherall, D J, and Higgs, D R

Abstract

A combination of polymorphic DNA markers, cytogenetic analysis, and in situ hybridisation has been used for the high resolution assignment of the human alpha globin gene cluster on chromosome 16. Multiallelic DNA probes from within the alpha globin cluster were used to determine the number of copies of this locus in three cell lines containing trisomies of the short arm of chromosome 16 and one with a familial inversion, inv(16). The breakpoints in these rearrangements flank the alpha globin locus and locate a shortest region of overlap to 16p13.1. A meiotic crossover was also localised to this band. In situ hybridisation of biotinylated DNA probes to normal and inverted chromosomes 16 [inv(16)(p13.1;q22)] showed hybridisation sites at opposite ends of the chromosomes, consistent with this regional localisation. [ABSTRACT FROM PUBLISHER]

Published
1987

231. G gamma beta + type of hereditary persistence of fetal haemoglobin in association with Hb C.

Author

Higgs, D R, Clegg, J B, Wood, W G, and Weatherall, D J

Abstract

This report describes a Negro family with the G gamma beta + type of hereditary persistence of fetal haemoglobin. Family members with levels of haemoglobin F of 17 to 23% had normal red cell indices, balanced globin chain synthesis, and a pancellular distribution of the fetal haemoglobin, showing that these subjects have a form of HPFH. The production of Hb A and C in addition to the large amount of Hb F in one family member showed that there was an active beta A gene in cis to the HPFH determinant, while structural analysis of the Hb F revealed the presence of only G gamma chains. The criteria for the diagnosis of G gamma beta + HPFH, and the relevance of such conditions to the control of globin gene expression, are discussed. [ABSTRACT FROM PUBLISHER]

Published
1979

237. THE DRYING OF TIMOTHY SEED 2. The rate of drying.

Author

Nellist, M. E., Rees, D. V. H., and Higgs, D. M. J.

Abstract

Physical data, from an experiment to determine the effect of drying on the quality of S48 timothy seed, are used to derive an equation relating the average drying rate of the seed to the temperature and flow of the drying air. The relationship, which can be of use in practical problems, demonstrates the importance of air temperature in determining the drying rate, particularly when compared with similar data for wheat. [ABSTRACT FROM AUTHOR]

Published
1966

238. THE DRYING OF TIMOTHY SEED 1. Effect on quality.

Author

Nellist, M. E., Rees, D. V. H., and Higgs, D. M. J.

Abstract

On 6 dates during a period of 14 days, S48 timothy seed was combine harvested directly and then dried in layers 6 in. deep at air temperatures of 77, 95, 104 and 122 ° F and airflows of 20 and 35 ft/min. The effect of these drying conditions upon subsequent laboratory germination was measured. An experimental drier of 8 units developed for this work is described. Results showed that the depression of germination by increasing temperatures depended on the stage of ripeness when the initial moisture content was greater than 30% wet basis.® Below this moisture level, no significant depression was found at temperatures up to 122 ° F. Seed of acceptable commercial standard was obtained when harvested at 41-3% m.c.w.b., but only under the gentlest drying treatment, 77 ° F and 20 ft/min. [ABSTRACT FROM AUTHOR]

Published
1965
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