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2,115 results on '"Hibi, T"'

203. H-dibaryon search by KEK-E522

Author

Yoon, C. J., primary, Akikawa, H., additional, Aoki, K., additional, Fukao, Y., additional, Funahashi, H., additional, Hayata, M., additional, Imai, K., additional, Miwa, K., additional, Okada, H., additional, Saito, N., additional, Sato, H. D., additional, Shoji, K., additional, Takahashi, H., additional, Taketani, K., additional, Asai, J., additional, Kurosawa, M., additional, Ieiri, M., additional, Hayakawa, T., additional, Kishimoto, T., additional, Sato, A., additional, Shimizu, Y., additional, Yamamoto, K., additional, Yoshida, T., additional, Hibi, T., additional, Nakazawa, K., additional, Ahn, J. K., additional, Choi, B. H., additional, Kim, S. J., additional, Kim, S. H., additional, Park, B. D., additional, Park, I. G., additional, Song, J. S., additional, Yoon, C. S., additional, Tanida, K., additional, and Ohnishi, A., additional

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211. P599 ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE 1 DEFICIENCY EXAGGERATES LIVER FIBROSIS THROUGH ENHANCED FREE CHOLESTEROL ACCUMULATION IN HEPATIC STELLATE CELLS

Author

Tomita, K., primary, Teratani, T., additional, Suzuki, T., additional, Shimizu, M., additional, Sato, H., additional, Narimatsu, K., additional, Usui, S., additional, Kimura, A., additional, Nishiyama, K., additional, Maejima, T., additional, Okada, Y., additional, Kurihara, C., additional, Shimamura, K., additional, Ebinuma, H., additional, Saito, H., additional, Yokoyama, H., additional, Watanabe, C., additional, Komoto, S., additional, Nagao, S., additional, Sugiyama, K., additional, Aozasa, S., additional, Hatsuse, K., additional, Yamamoto, J., additional, Hibi, T., additional, Miura, S., additional, Hokari, R., additional, and Kanai, T., additional

Published
2014
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215. Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health

Author

Peyrin-Biroulet, L, Cieza, A, Sandborn, WJ, Coenen, M, Chowers, Y, Hibi, T, Kostanjsek, N, Stucki, G, Colombel, J-F, Peyrin-Biroulet, L, Cieza, A, Sandborn, WJ, Coenen, M, Chowers, Y, Hibi, T, Kostanjsek, N, Stucki, G, and Colombel, J-F

Abstract

OBJECTIVE: The impact of inflammatory bowel disease (IBD) on disability remains poorly understood. The World Health Organization's integrative model of human functioning and disability in the International Classification of Functioning, Disability and Health (ICF) makes disability assessment possible. The ICF is a hierarchical coding system with four levels of details that includes over 1400 categories. The aim of this study was to develop the first disability index for IBD by selecting most relevant ICF categories that are affected by IBD. METHODS: Relevant ICF categories were identified through four preparatory studies (systematic literature review, qualitative study, expert survey and cross-sectional study), which were presented at a consensus conference. Based on the identified ICF categories, a questionnaire to be filled in by clinicians, called the 'IBD disability index', was developed. RESULTS: The four preparatory studies identified 138 second-level categories: 75 for systematic literature review (153 studies), 38 for qualitative studies (six focus groups; 27 patients), 108 for expert survey (125 experts; 37 countries; seven occupations) and 98 for cross-sectional study (192 patients; three centres). The consensus conference (20 experts; 17 countries) led to the selection of 19 ICF core set categories that were used to develop the IBD disability index: seven on body functions, two on body structures, five on activities and participation and five on environmental factors. CONCLUSIONS: The IBD disability index is now available. It will be used in studies to evaluate the long-term effect of IBD on patient functional status and will serve as a new endpoint in disease-modification trials.

Published
2012

216. Development of the Crohn's Disease Digestive Damage Score, the Lemann Score

Author

Pariente, B, Cosnes, J, Danese, S, Sandborn, WJ, Lewin, M, Fletcher, JG, Chowers, Y, D'Haens, G, Feagan, BG, Hibi, T, Hommes, DW, Irvine, EJ, Kamm, MA, Loftus, EV, Louis, E, Michetti, P, Munkholm, P, Oresland, T, Panes, J, Peyrin-Biroulet, L, Reinisch, W, Sands, BE, Schoelmerich, J, Schreiber, S, Tilg, H, Travis, S, van Assche, G, Vecchi, M, Mary, J-Y, Colombel, J-F, Lemann, M, Pariente, B, Cosnes, J, Danese, S, Sandborn, WJ, Lewin, M, Fletcher, JG, Chowers, Y, D'Haens, G, Feagan, BG, Hibi, T, Hommes, DW, Irvine, EJ, Kamm, MA, Loftus, EV, Louis, E, Michetti, P, Munkholm, P, Oresland, T, Panes, J, Peyrin-Biroulet, L, Reinisch, W, Sands, BE, Schoelmerich, J, Schreiber, S, Tilg, H, Travis, S, van Assche, G, Vecchi, M, Mary, J-Y, Colombel, J-F, and Lemann, M

Abstract

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be "diagnostic modality driven": for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lémann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage.

Published
2011

217. Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase

Author

Sato, A., Sato, Y., Fukao, Y., Fujiwara, M., Umezawa, T., Shinozaki, K., Hibi, T., Taniguchi, M., Miyake, H., Goto, D.B., Uozumi, N., Sato, A., Sato, Y., Fukao, Y., Fujiwara, M., Umezawa, T., Shinozaki, K., Hibi, T., Taniguchi, M., Miyake, H., Goto, D.B., and Uozumi, N.

Abstract

The Arabidopsis thaliana K+ channel KAT1 has been suggested to have a key role in mediating the aperture of stomata pores on the surface of plant leaves. Although the activity of KAT1 is thought to be regulated by phosphorylation, the endogenous pathway and the primary target site for thismodification remained unknown. In the present study, we have demonstrated that the C-terminal region of KAT1 acts as a phosphorylation target for the Arabidopsis calcium-independent ABA (abscisic acid)-activated protein kinase SnRK2.6 (Snf1-related protein kinase 2.6). This was confirmed by LC-MS/MS (liquid chromatography tandem MS) analysis, which showed that Thr306 and Thr308 of KAT1 were modified by phosphorylation. The role of these specific residues was examined by single point mutations and measurement of KAT1 channel activities in Xenopus oocyte and yeast systems. Modification of Thr308 hadminimal effect onKAT1 activity. On the other hand, modification of Thr306 reduced the K+ transport uptake activity of KAT1 in both systems, indicating that Thr306 is responsible for the functional regulation of KAT1. These results suggest that negative regulation of KAT1 activity, required for stomatal closure, probably occurs by phosphorylation of KAT1 Thr306 by the stress-activated endogenous SnRK2.6 protein kinase.

Published
2009

218. Prospective blinded study of magnetically guided capsule vs. conventional gastroscopy for upper abdominal complaints

Author

Denzer, UW, primary, Rösch, T, additional, Hoytat, B, additional, Abdel-Hamid, M, additional, Hebuterne, X, additional, Vanbiervielt, G, additional, Filippi, J, additional, Ogata, H, additional, Hosoe, N, additional, Ohtsuka, K, additional, Ogata, N, additional, Ikeda, K, additional, Aihara, H, additional, Hibi, T, additional, Kudo, SE, additional, Tajiri, H, additional, Treszl, A, additional, Wegscheider, K, additional, Greff, M, additional, and Rey, JF, additional

Published
2013
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225. 1302 THE CHARACTERISTIC MECHANISMS OF FREE CHOLESTEROL ACCUMULATION IN HEPATIC STELLATE CELLS AGGRAVATE LIVER FIBROSIS IN NONALCOHOLIC STEATOHEPATITIS IN MICE

Author

Tomita, K., primary, Teratani, T., additional, Suzuki, T., additional, Shimizu, M., additional, Sato, H., additional, Okada, Y., additional, Kurihara, C., additional, Yokoyama, H., additional, Irie, R., additional, Ebinuma, H., additional, Saito, H., additional, Watanabe, C., additional, Komoto, S., additional, Hokari, R., additional, Kawaguchi, A., additional, Nagao, S., additional, Sugiyama, K., additional, Kanai, T., additional, Hibi, T., additional, and Miura, S., additional

Published
2013
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233. P238 Feasibility of the second-generation colon capsule endoscopy in patients with ulcerative colitis with a reduced preparation regimen

Author

Kobayashi, T., primary, Hosoe, N., additional, Matsuoka, K., additional, Naganuma, M., additional, Nakano, M., additional, Ishibashi, Y., additional, Kimura, K., additional, Yoneno, K., additional, Usui, S., additional, Kashiwagi, K., additional, Hisamatsu, T., additional, Inoue, N., additional, Serizawa, H., additional, Watanabe, N., additional, Kanai, T., additional, Imaeda, H., additional, Hibi, T., additional, and Ogata, H., additional

Published
2013
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234. Phenotypic concordance and time clustering of diagnosis in multiply affected ibd families : the IOIBD Multiplex Family Collaborative Project, phases I & II

Author

Tamboli, C., Attaluri, A., Yan, J., Duke, A., Colombel, J. F., Silverberg, M., McLeod, R., Jewell, D., Goldthorpe, S., Vernier, G., Vermeire, S., Joossens, M., Chapman, J. O., Bernstein, C., Annese, V., Lombardi, G., Bengtson, M. B., Vatn, M., Halfvarson, Jonas, Tysk, C., Jess, T., Riis, L., Timmer, A., Bauer, A., Korelitz, B., Sultan, K., Reinisch, W., Biancone, L., Pallone, F., Hibi, T., Tamboli, C., Attaluri, A., Yan, J., Duke, A., Colombel, J. F., Silverberg, M., McLeod, R., Jewell, D., Goldthorpe, S., Vernier, G., Vermeire, S., Joossens, M., Chapman, J. O., Bernstein, C., Annese, V., Lombardi, G., Bengtson, M. B., Vatn, M., Halfvarson, Jonas, Tysk, C., Jess, T., Riis, L., Timmer, A., Bauer, A., Korelitz, B., Sultan, K., Reinisch, W., Biancone, L., Pallone, F., and Hibi, T.

Published
2005

236. Impact of Steroids on Natural Killer Cells Against Cytotoxicity and Hepatitis C Virus Replication

Author

Ohira, M., primary, Nishida, S., additional, Matsuura, T., additional, Misawa, R., additional, Hibi, T., additional, Uchida, K., additional, Dohi, T., additional, Fan, J., additional, Tekin, A., additional, Levi, D., additional, Selvaggi, G., additional, Tryphonopoulos, P., additional, Ruiz, P., additional, Weppler, D., additional, Ricordi, C., additional, Ohdan, H., additional, and Tzakis, A., additional

Published
2012
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238. Liver Grafts Contain a Large Number of CD52 Negative Natural Killer Cells: Role for Infections after Liver Transplantation with Alemtuzumab Induction

Author

Matsuura, T., primary, Nishida, S., additional, Ohira, M., additional, Hibi, T., additional, Uchida, K., additional, Dohi, T., additional, Fan, J., additional, Tekin, A., additional, Selvaggi, G., additional, Levi, D., additional, Tryphonopoulos, P., additional, Ruiz, P., additional, Weppler, D., additional, Khan, A., additional, Linetsky, E., additional, Ricordi, C., additional, Ohdan, H., additional, and Tzakis, A. G., additional

Published
2012
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239. Analysis of Liver Transplant without Blood Transfusion in Adult Patients

Author

Nishida, S., primary, Ohira, M., additional, Tryphonopoulos, P., additional, Mosna, L., additional, Matsuura, T., additional, Uchida, K., additional, Hibi, T., additional, Dohi, T., additional, Fan, J., additional, Tekin, A., additional, Selvaggi, G., additional, Levi, D., additional, Fukazawa, K., additional, Pretto, E., additional, Weppler, D., additional, Ruiz, P., additional, and Tzakis, A., additional

Published
2012
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240. Binding of T Cell Depletion Antibody to Natural Killer Cells Leads to Anti-Hepatitis C Effects via Interferon-γ Production

Author

Ohira, M., primary, Nishida, S., additional, Matsuura, T., additional, Misawa, R., additional, Hibi, T., additional, Uchida, K., additional, Dohi, T., additional, Fan, J., additional, Tekin, A., additional, Selvaggi, G., additional, Levi, D., additional, Tryphonopoulos, P., additional, Weppler, D., additional, Ruiz, P., additional, Ricordi, C., additional, Ohdan, H., additional, and Tzakis, A., additional

Published
2012
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248. Pharmacokinetics of Mizoribine in Adult Living Donor Liver Transplantation

Author

Shinoda, M., primary, Tanabe, M., additional, Kawachi, S., additional, Ono, Y., additional, Hayakawa, T., additional, Iketani, O., additional, Kojima, M., additional, Itano, O., additional, Obara, H., additional, Kitago, M., additional, Hibi, T., additional, Matsubara, K., additional, Shimojima, N., additional, Fuchimoto, Y., additional, Hoshino, K., additional, Wakabayashi, G., additional, Shimazu, M., additional, Tanigawara, Y., additional, Kuroda, T., additional, Morikawa, Y., additional, Kitajima, M., additional, and Kitagawa, Y., additional

Published
2012
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