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Aim: To investigate the incidence and the causes of burns and scalds in young children, using an ecological model based on data from a representative population based cohort. Method: With [...]

Conventional CMOS based logic and magnetic based data storage devices require the shuttling of electrons for data processing and storage. As these devices are scaled to increasingly smaller dimensions in the pursuit of speed and storage density, significant energy dissipation in the form of heat has become a center stage issue for the microelectronics industry. By taking advantage of the strong correlations between ferroic orders in multiferroics, specifically the coupling between ferroelectric and magnetic orders (magnetoelectricity), new device functionalities with ultra-low energy consumption can be envisioned. In this article, we review the advances and highlight challenges toward this goal with a particular focus on the room temperature magnetoelectric multiferroic, BiFeO3, exchange coupled to a ferromagnet. We summarize our understanding of the nature of exchange coupling and the mechanisms of the voltage control of ferromagnetism observed in these heterostructures. [ABSTRACT FROM AUTHOR]

Background. It is unclear whether pubertal status or timing of puberty explains the increase in depressive symptoms in girls during adolescence. Method. This is a longitudinal study based on 2506 girls from the Avon Longitudinal Study of Parents and Children (ALSPAC). Self-reported depressive symptoms at 10.5, 13 and 14 years were assessed using the Short Mood and Feelings Questionnaire (SMFQ). Pubertal status (Tanner breast and pubic hair stage) and timing of menarche were derived from questionnaires administered from age 8 to 14 years. We used multivariable regression models to examine the relative contributions of pubertal status and timing in accounting for increases in level of depressive symptoms at 14 years. Results. With increasing age, the association between breast development and depressive symptoms strengthened. Pubertal status (breast stage), rather than timing of menarche, was independently associated with depressive symptoms at 14 years. There was strong evidence for a linear relationship between breast stage and depressive symptoms at 14 years [increase in 0.17 S.D. (range 0.10-0.24) of depressive symptoms for advancement of each breast stage]. Conclusions. Depressive symptoms in mid-adolescence were more strongly influenced by breast stage than timing of menarche. This could imply that the female rise in depression during adolescence is due to increasing estrogen levels, and might explain why the gender difference in rates of depression emerges at this stage. Future research should be aimed at identifying the mechanism of action of pubertal change, including direct effects of pubertal hormones and indirect effects mediated by psychosocial factors. [ABSTRACT FROM AUTHOR]

The aim of the study was to investigate the influence of alcohol exposure during pregnancy on a mother's responsiveness towards her infant after birth. Using longitudinal data from a subsample of 687 mother-infant dyads from a UK cohort study (Avon Longitudinal Study of Parents and Children), we investigated the influence of alcohol use during mid- and late pregnancy on observed mother-infant interactions after birth. We found that women who drank one or more glasses of alcohol a week during their mid-trimester of pregnancy were 19 % (95 % CI, 1 to 40 %; p = 0.033) more likely to show non-responsive behaviour towards their infant 12 months after birth. In contrast, we found that alcohol use during late pregnancy was not associated with later maternal responsiveness. This study adds to the growing evidence for the importance of factors during pregnancy on later maternal responsiveness. Further research is needed to replicate these findings and to examine potential mechanisms linking maternal responsiveness to alcohol use during pregnancy. [ABSTRACT FROM AUTHOR]

Abstract: Aims: The perinatal period is a time of high risk of relapse for women with a history of bipolar affective disorder (BPAD). We describe the pregnancy management of women with BPAD and identify risk factors for postpartum relapse. Methods: The case records of 78 women with BPAD referred to perinatal mental health services before conception, during pregnancy or the postpartum period, between 1998 and 2009 in Birmingham UK, were screened. In women who were managed during pregnancy, those who relapsed in the postpartum were compared with those who remained well. Results: Forty-seven percent of women with BPAD referred in pregnancy suffered postpartum relapse. Women who were unwell at referral, younger, with unplanned pregnancy, previous perinatal episodes or a family history of BPAD were more likely to suffer postpartum illness. Conclusion: Identifying risk factors for postpartum relapse enables us to individualise the estimation of a woman''s risk and modify care plans accordingly. Duration of wellness prior to pregnancy is not associated with a lower risk of postpartum illness and so it is imperative that all women with BPAD receive referral in pregnancy. [Copyright &y& Elsevier]

Background Both maternal and paternal depression during the perinatal period are associated with adverse effects on child outcomes. Attention has started to focus on the mechanisms mediating these relationships. Marital conflict may play a role in this context. Methods In a large cohort study, the Avon Longitudinal Study of Parents and Children ( n= 14 541 pregnancies), we aimed to (i) investigate the relative influences of parental postnatal depression and marital conflict on child outcomes and to attempt to determine the pathway(s) of risk; (ii) investigate the impact of two types of antenatal stress (parental depression and marital conflict) on child outcomes; and (iii) determine the relative contributions of antenatal and postnatal risk. Parents completed the Edinburgh Postnatal Depression Scale and a marital conflict scale during the second trimester and at 8 months postnatally. Child outcomes were assessed at 42 months using the Rutter revised pre-school scales. Results Marital conflict partially mediated the relationship between postnatal depression in both mothers and fathers and child outcomes, and acted as an independent risk for adverse outcomes. Parental depression (maternal and paternal) and marital conflict in the antenatal period were both associated with adverse effects which persisted even when postnatal stresses were taken into account. Conclusions These findings, if replicated, suggest that screening and intervention programmes targeted at parental depression and marital problems should be considered antenatally, as well as postnatally. [ABSTRACT FROM AUTHOR]

Abstract: Background: An infant''s early environment has an important influence on their development. For example, the sensitivity and warmth of a mother''s responses towards her infant is associated with the infant''s later socio-emotional development. However, it is less clear whether maternal responses are associated with the infant''s later cognitive development. Method: We used data from a large UK cohort study to investigate the association between non-verbal maternal responses and later infant development and IQ. Maternal responses were rated at 12 months during an observed mother–infant interaction. Infant development was assessed using the Griffiths scales at 18 months and IQ at 4 years was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Data on the infant''s developmental level at 6 months (prior to the maternal response ratings) was also available. The complete case sample comprised 732 mother–infant pairs. Results: There was evidence for an association between positive maternal responses and infant development at 18 months. After adjusting for infant developmental level at 6 months and other confounders, we found a difference of 0.25 standard deviations (coef 2.0, 95% CI (0.8–3.2), p =0.002) on the Griffiths scales between infant''s whose mothers showed positive compared to neutral non-verbal responses at 12 months. However, an association between positive maternal responses and IQ at 4 years diminished following adjustment for maternal educational attainment. Conclusion: The results provide evidence that positive maternal responses are associated with improved development in infants at 18 months. However, the association between maternal response and IQ at 4 years may be explained by higher educational attainment in mothers who show positive responses. Future studies are needed to explore the influence of maternal responses on different aspects of infant development as well as the role of maternal factors such as education. [Copyright &y& Elsevier]

Please cite this paper as: Flach C, Leese M, Heron J, Evans J, Feder G, Sharp D, Howard L. Antenatal domestic violence, maternal mental health and subsequent child behaviour: a cohort study. BJOG 2011;118:1383-1391. Objective To investigate the long-term impact of antenatal domestic violence on maternal psychiatric morbidity and child behaviour. Design Cohort study. Setting Avon, UK. Population or sample A birth cohort of 13 617 children and mother dyads were followed to 42 months of age. Methods Experiences of domestic violence and depressive symptoms were gathered at 18 weeks of gestation and up to 33 months after birth, together with maternal, paternal and child characteristics. Main outcome measures Child behavioural problems were assessed at 42 months using the Revised Rutter Questionnaire. Analysis Logistic regression with the use of multiple imputation employing chained equations for missing data. Results Antenatal domestic violence was associated with high levels of maternal antenatal (odds ratio [OR], 4.02; 95% confidence interval [CI], 3.4-4.8) and postnatal (OR, 1.29; 95% CI, 1.02-1.63) depressive symptoms after adjustment for potential confounders. Antenatal domestic violence predicted future behavioural problems at 42 months in the child before adjustment for possible confounding and mediating factors (OR, 1.87; 95% CI, 1.45-2.40); this association was not significant after adjustment for high levels of maternal antenatal depressive symptoms, postnatal depressive symptoms or domestic violence since birth. Conclusions Antenatal domestic violence is associated with high levels of both maternal antenatal and postnatal depressive symptoms. It is also associated with postnatal violence, and both are associated with future behavioural problems in the child at 42 months. This is partly mediated by maternal depressive symptoms in the ante- or postnatal period. [ABSTRACT FROM AUTHOR]

Microfabrication techniques have made possible the realization of mechanical devices with dimensions in the micro- and nano-scale domain. At low temperatures, one can operate and study these devices in well-controlled conditions, namely low electrical noise and cryogenic vacuum, with the ability to use high magnetic fields and superconducting coating metals (Collin et al. in J. Low Temp. Phys. 150(5-6):739, ). Moreover, the temperature turns out to be a control parameter in the experimental study of mechanical dissipation processes, with the cryogenic environment ensuring that only low energy states are thermally populated. Immersed in a quantum fluid, these MEMS and NEMS devices (micro and nano electro-mechanical systems) can probe the excitations of the liquid at a smaller scale, with higher frequencies and better resolution than 'classical' techniques (Triqueneaux et al. in Physica B 284:2141, ). We present experimental results obtained in vacuum on cantilever NEMS structures which can be both magnetomotive and electrostatically driven. The device is extremely sensitive with resolved displacements down to 1 Å using conventional room-temperature electronics. It is calibrated in situ, and frequency/non-linearity can be tuned electrostatically. The design should allow parametric amplification to be used. [ABSTRACT FROM AUTHOR]

Within the Information System on Occupational Exposure in Medicine, Industry and Research (ISEMIR), a new International Atomic Energy Agency initiative, a Working Group on interventional cardiology, aims to assess staff radiation protection (RP) levels and to propose an international database of occupational exposures. A survey of regulatory bodies (RBs) has provided information at the country level on RP practice in interventional cardiology (IC). Concerning requirements for wearing personal dosemeters, only 57 % of the RB specifies the number and position of dosemeters for staff monitoring. Less than 40 % of the RBs could provide occupational doses. Reported annual median effective dose values (often <0.5 mSv) were lower than expected considering validated data from facility-specific studies, indicating that compliance with continuous individual monitoring is often not achieved in IC. A true assessment of annual personnel doses in IC will never be realised unless a knowledge of monitoring compliance is incorporated into the analysis. [ABSTRACT FROM PUBLISHER]