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1,733 results on '"Hengstler, Jan G."'

201. A Systematic Analysis of Biological, Sociodemographic, Psychosocial, and Lifestyle Factors Contributing to Work Ability Across the Working Life Span: Cross-sectional Study (Preprint)

Author

Gajewski, Patrick D, primary, Rieker, Jennifer A, additional, Athanassiou, Georgios, additional, Bröde, Peter, additional, Claus, Maren, additional, Golka, Klaus, additional, Hengstler, Jan G, additional, Kleinsorge, Thomas, additional, Nitsche, Michael A, additional, Reinders, Jörg, additional, Tisch, Anita, additional, Watzl, Carsten, additional, Wascher, Edmund, additional, and Getzmann, Stephan, additional

Published
2022
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202. Reprogramming necroptosis limits immune responses and prevents liver cancer development

Author

Vucur, Mihael, primary, Ghallab, Ahmed, additional, Schneider, Anne, additional, Kather, Jakob, additional, Govaere, Olivier, additional, Villanueva, Augusto, additional, Weber, Achim, additional, Longerich, Thomas, additional, Tacke, Frank, additional, Roderburg, Christoph, additional, Bode, Johannes, additional, Geisler, Fabian, additional, Neumann, Ulf, additional, Hengstler, Jan G., additional, Heikenwälder, Mathias, additional, and Lüdde, Tom, additional

Published
2022
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203. Biliary epithelial cell-specific RAGE controls ductular reaction-mediated fibrosis during cholestasis

Author

Macrina Lam, Wai Ling, primary, Damle-Vartak, Amruta, additional, Gabernet, Gisela, additional, Schneller, Doris, additional, Poth, Tanja, additional, Jörs, Simone, additional, Sator-Schmitt, Melanie, additional, De Ponti, Aurora, additional, Weiß, Lena, additional, Heikenwälder, Mathias, additional, Vartak, Nachiket, additional, Hengstler, Jan G., additional, Geisler, Fabian, additional, Nahnsen, Sven, additional, and Angel, Peter, additional

Published
2022
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204. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

Author

Ghallab, Ahmed, primary, Hassan, Reham, additional, Hofmann, Ute, additional, Friebel, Adrian, additional, Hobloss, Zaynab, additional, Brackhagen, Lisa, additional, Begher-Tibbe, Brigitte, additional, Myllys, Maiju, additional, Reinders, Joerg, additional, Overbeck, Nina, additional, Sezgin, Selahaddin, additional, Zühlke, Sebastian, additional, Seddek, Abdel-latif, additional, Murad, Walaa, additional, Brecklinghaus, Tim, additional, Kappenberg, Franziska, additional, Rahnenführer, Jörg, additional, González, Daniela, additional, Goldring, Christopher, additional, Copple, Ian M., additional, Marchan, Rosemarie, additional, Longerich, Thomas, additional, Vucur, Mihael, additional, Luedde, Tom, additional, Urban, Stephan, additional, Canbay, Ali, additional, Schreiter, Thomas, additional, Trauner, Michael, additional, Akakpo, Jephte Y., additional, Olyaee, Mojtaba, additional, Curry, Steven C., additional, Sowa, Jan-Peter, additional, Jaeschke, Hartmut, additional, Hoehme, Stefan, additional, and Hengstler, Jan G., additional

Published
2022
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206. Liver-specific Tsg101 depletion causes apoptosis, cell death and liver failure

Author

Wang, Surui, primary, Sekar, Revathi, additional, Cendrowski, Jaroslaw, additional, Ghallab, Ahmed, additional, Motzler, Karsten, additional, Kwon, Yun, additional, Seitz, Susanne, additional, Roden, Michael, additional, Maida, Adriano, additional, Hengstler, Jan G., additional, Herzig, Stephan, additional, Miaczynska, Marta, additional, and Zeigerer, Anja, additional

Published
2022
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211. Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer

Author

Selinski, Silvia, Blaszkewicz, Meinolf, Ickstadt, Katja, Gerullis, Holger, Otto, Thomas, Roth, Emanuel, Volkert, Frank, Ovsiannikov, Daniel, Moormann, Oliver, Banfi, Gergely, Nyirady, Peter, Vermeulen, Sita H, Garcia-Closas, Montserrat, Figueroa, Jonine D, Johnson, Alison, Karagas, Margaret R, Kogevinas, Manolis, Malats, Nuria, Schwenn, Molly, Silverman, Debra T, Koutros, Stella, Rothman, Nathaniel, Kiemeney, Lambertus A, Hengstler, Jan G, and Golka, Klaus

Published
2017
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214. “Watching the Detectives” report of the general assembly of the EU project DETECTIVE Brussels, 24–25 November 2015

Author

Fernando, Ruani N., Chaudhari, Umesh, Escher, Sylvia E., Hengstler, Jan G., Hescheler, Jürgen, Jennings, Paul, Keun, Hector C., Kleinjans, Jos C. S., Kolde, Raivo, Kollipara, Laxmikanth, Kopp-Schneider, Annette, Limonciel, Alice, Nemade, Harshal, Nguemo, Filomain, Peterson, Hedi, Prieto, Pilar, Rodrigues, Robim M., Sachinidis, Agapios, Schäfer, Christoph, Sickmann, Albert, Spitkovsky, Dimitry, Stöber, Regina, van Breda, Simone G. J., van de Water, Bob, Vivier, Manon, Zahedi, René P., Vinken, Mathieu, and Rogiers, Vera

Published
2016
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223. Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Author

Cherianidou, Anna, primary, Seidel, Florian, additional, Kappenberg, Franziska, additional, Dreser, Nadine, additional, Blum, Jonathan, additional, Waldmann, Tanja, additional, Blüthgen, Nils, additional, Meisig, Johannes, additional, Madjar, Katrin, additional, Henry, Margit, additional, Rotshteyn, Tamara, additional, Marchan, Rosemarie, additional, Edlund, Karolina, additional, Leist, Marcel, additional, Rahnenführer, Jörg, additional, Sachinidis, Agapios, additional, and Hengstler, Jan G., additional

Published
2022
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224. Modeling hepatic osteodystrophy in Abcb4 deficient mice

Author

Hochrath, Katrin, Ehnert, Sabrina, Ackert-Bicknell, Cheryl L., Lau, Yvonne, Schmid, Andrea, Krawczyk, Marcin, Hengstler, Jan G., Dunn, Jordanne, Hiththetiya, Kanishka, Rathkolb, Birgit, Micklich, Kateryna, Hans, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valérie, Wolf, Eckhard, de Angelis, Martin Hrabě, Dooley, Steven, Paigen, Beverly, Wildemann, Britt, Lammert, Frank, and Nüssler, Andreas K.

Published
2013
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225. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer

Author

Lohr, Miriam, Edlund, Karolina, Botling, Johan, Hammad, Seddik, Hellwig, Birte, Othman, Amnah, Berglund, Anders, Lambe, Mats, Holmberg, Lars, Ekman, Simon, Bergqvist, Michael, Pontén, Fredrik, Cadenas, Cristina, Marchan, Rosemarie, Hengstler, Jan G., Rahnenführer, Jörg, and Micke, Patrick

Published
2013
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228. Integrated spatial-temporal model for the prediction of interplay between biomechanics and cell kinetics in fibrotic street formation

Author

Zhao, Jieling, Hammad, Seddik, De langlard, Mathieu, Erdoesi, Pia, Li, Yueni, Buttenschön, Andreas, Hengstler, Jan G., Ebert, Matthias, Dooley, Steven, Drasdo, Dirk, Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), SImulations en Médecine, BIOtechnologie et ToXicologie de systèmes multicellulaires (SIMBIOTX ), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Heidelberg, Medical Faculty, University of British Columbia (UBC), and Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
[PHYS]Physics [physics], Agent based Modeling, [SDV]Life Sciences [q-bio], Virtual Liver
Abstract

Upon different types of liver injury, there are distinct patterns of hepatic fibrosis developed, such as ECM septa (fibrotic walls) connecting pericentral (CV) areas due to toxic injury or septa connecting portal (PV) compartments due to cholestatic injury. Since liver fibrosis is a multi-cellular process and difficult to capture for biological in vivo and in vitro models, computational models may shed light on exploring the mechanisms behind particular pattern formation. In this work, we present a novel computational liver model that permits to assess the potential role of biomechanics in the formation of fibrotic walls. It for the first time studies the orchestration of cell types during fibrosis development and the interaction of cell populations with the ECM network mechanics in a liver lobule. Our model results are quantitatively confronted with experimental findings. The determination of the pattern-characterizing parameters in this study e.g. the density of hepatic stellate cells (HSC) and macrophages (MC) were obtained through image analysis of 2D and 3D images from mouse experiments. Together with a model of ECM networks, these non-parenchymal cells and their intercellular signaling were integrated as new elements into computational model of basic liver micro-architecture that included hepatocytes (the main parenchymal liver cell), sinusoids, CV and PV. The new model is applied to test possible mechanisms of how the fibrotic wall may form during liver fibrosis in space and time.

Published
2022

229. Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung

Author

Hengstler, Jan G, Baum, Matthias, Cartus, Alexander, Diel, Patrick, Eisenbrand, Gerhard, Karl-Heinz Engel, Engeli, Barbara, Epe, Bernd, Grune, Tilman, Guth, Sabine, Haller, Dirk, Heinz, Volker, Hellwig, Michael, Henle, Thomas, Hans-Ulrich Humpf, Jäger, Henry, Hans-Georg Joost, Kulling, Sabine E, Lachenmeier, Dirk W, Lampen, Alfonso, Leist, Marcel, Mally, Angela, Marko, Doris, Nöthlings, Ute, Röhrdanz, Elke, Roth, Angelika, Spranger, Joachim, Stadler, Richard H, Steinberg, Pablo, Vieths, Stefan, and Wätjen, Wim

Published
2022
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232. Citrinin Exposure in Germany: Urine Biomarker Analysis in Children and Adults.

Author

Degen, Gisela H., Reinders, Jörg, Kraft, Martin, Völkel, Wolfgang, Gerull, Felicia, Burghardt, Rafael, Sievering, Silvia, Engelmann, Jennifer, Chovolou, Yvonni, Hengstler, Jan G., and Fromme, Hermann

Subjects
URINALYSIS, CITRININ, GERMANS, BIOLOGICAL monitoring, YOUNG adults, BIOMARKERS, FOOD safety
Abstract

Citrinin (CIT), a mycotoxin known to exert nephrotoxicity, is a contaminant in food and feed. Since CIT contamination is not regularly analyzed, data on its occurrence and especially levels in food commodities are insufficient for conducting a conventional exposure assessment. Yet, human biomonitoring, i.e., an analysis of CIT and its metabolite dihydrocitrinone (DH-CIT) in urine samples allows to estimate exposure. This study investigated CIT exposure in young (2–14 years) and adult (24–61 years) residents of three federal states in Germany. A total of 179 urine samples from children and 142 from adults were collected and analyzed by a targeted LC-MS/MS based method for presence of CIT and DH-CIT. At least one of the biomarkers was detected and quantified in all urines, which indicated a widespread dietary exposure to the mycotoxin in Germany. Interestingly, the biomarker concentrations of CITtotal (sum of CIT and DH-CIT) were higher in children's urine (range 0.05–7.62 ng/mL; median of 0.54 ng/mL) than in urines from adults (range 0.04–3.5 ng/mL; median 0.3 ng/mL). The biomarker levels (CITtotal) of individual urines served to calculate the probable daily CIT intake, for comparison to a value of 0.2 µg/kg bw/day defined as 'level of no concern for nephrotoxicity' by the European Food Safety Authority. The median exposure of German adults was 0.013 µg/kg b.w., with only one urine donor exceeding this provisional tolerable daily intake (pTDI) for CIT. The median exposure of children was 0.05 µg/kg bw per day (i.e., 25% of the pTDI); however, CIT exposure in 12 individuals (6.3% of our study group) exceeded the limit value, with a maximum intake of 0.46 µg/kg b.w. per day. In conclusion, these results show evidence for non-negligible exposure to CIT in some individuals in Germany, mainly in children. Therefore, further biomonitoring studies and investigations aimed to identify the major sources of CIT exposure in food commodities are required. [ABSTRACT FROM AUTHOR]

Published
2023
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233. BLADDER CANCER COURSE, FOUR GENETIC HIGH-RISK VARIANTS, AND HISTOPATHOLOGICAL FINDINGS.

Author

Kadhum, Thura, Selinski, Silvia, Blaszkewicz, Meinolf, Reinders, Jörg, Roth, Emanuel, Volkert, Frank, Ovsiannikov, Daniel, Moormann, Oliver, Gerullis, Holger, Barski, Dimitri, Otto, Thomas, Höhne, Svetlana, Hengstler, Jan G., and Golka, Klaus

Subjects
NON-muscle invasive bladder cancer, BLADDER cancer, GENETIC variation, GENOME-wide association studies, SINGLE nucleotide polymorphisms
Abstract

Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC) are rare. Thus we investigated 4 single nucleotide polymorphisms (SNPs) detected in GWAS, related to the genes coding for TACC3 (transforming, acidic coiled-coil containing protein 3), for FGFR3 (fibroblast growth factor receptor 3), for PSCA (prostate stem cell antigen) and the genes coding for CBX6 (chromobox homolog 6) and APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A). This study is based on 712 bladder cancer patients and 875 controls from 3 different case control studies in Germany. The 4 SNPs of interest (PSCA rs2294008 and rs2978974, FGFR3-TACC3 rs798766, and CBX6-APOBEC3A rs1014971) were determined by real-time polymerase chain reaction. The distribution of the 4 SNPs does not vary significantly between cases and controls in the entire study group and in the 3 local subgroups, including two former highly industrialized areas and a region without such history. Also, no significant differences in the bladder cancer subgroups of MIBC and NMIBC were observed. The 4 investigated SNPs do not noticeably contribute differently to the bladder cancer risk for the bladder cancer subgroups of MIBC and NMIBC. [ABSTRACT FROM AUTHOR]

Published
2023
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235. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Author

Rempel, Eugen, Hoelting, Lisa, Waldmann, Tanja, Balmer, Nina V., Schildknecht, Stefan, Grinberg, Marianna, Das Gaspar, John Antony, Shinde, Vaibhav, Stöber, Regina, Marchan, Rosemarie, van Thriel, Christoph, Liebing, Julia, Meisig, Johannes, Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., and Leist, Marcel

Published
2015
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236. Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

Author

Stewart, Joanna D., Marchan, Rosemarie, Lesjak, Michaela S., Lambert, Joerg, Hergenroeder, Roland, Ellis, James K., Lau, Chung-Ho, Keun, Hector C., Schmitz, Gerd, Schiller, Juergen, Eibisch, Mandy, Hedberg, Christian, Waldmann, Herbert, Lausch, Ekkehart, Tanner, Berno, Sehouli, Jalid, Sagemueller, Jens, Staude, Hagen, Steiner, Eric, and Hengstler, Jan G.

Published
2012

238. Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study

Author

Gajewski, Patrick D, primary, Getzmann, Stephan, additional, Bröde, Peter, additional, Burke, Michael, additional, Cadenas, Cristina, additional, Capellino, Silvia, additional, Claus, Maren, additional, Genç, Erhan, additional, Golka, Klaus, additional, Hengstler, Jan G, additional, Kleinsorge, Thomas, additional, Marchan, Rosemarie, additional, Nitsche, Michael A, additional, Reinders, Jörg, additional, van Thriel, Christoph, additional, Watzl, Carsten, additional, and Wascher, Edmund, additional

Published
2022
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241. Correction to: Toxicogenomics directory of chemically exposed human hepatocytes

Author

Grinberg, Marianna, primary, Stöber, Regina M., additional, Edlund, Karolina, additional, Rempel, Eugen, additional, Godoy, Patricio, additional, Reif, Raymond, additional, Widera, Agata, additional, Madjar, Katrin, additional, Schmidt-Heck, Wolfgang, additional, Marchan, Rosemarie, additional, Sachinidis, Agapios, additional, Spitkovsky, Dimitry, additional, Hescheler, Jürgen, additional, Carmo, Helena, additional, Arbo, Marcelo D., additional, van de Water, Bob, additional, Wink, Steven, additional, Vinken, Mathieu, additional, Rogiers, Vera, additional, Escher, Sylvia, additional, Hardy, Barry, additional, Mitic, Dragana, additional, Apic, Gordana, additional, Myatt, Glenn, additional, Waldmann, Tanja, additional, Mardinoglu, Adil, additional, Damm, Georg, additional, Seehofer, Daniel, additional, Nüssler, Andreas, additional, Weiss, Thomas S., additional, Oberemm, Axel, additional, Lampen, ·Alfons, additional, Schaap, Mirjam M., additional, Luijten, Mirjam, additional, van Steeg, Harry, additional, Thasler, Wolfgang E., additional, Kleinjans, Jos C. S., additional, Stierum, Rob H., additional, Leist, ·Marcel, additional, Rahnenführer, Jörg, additional, and Hengstler, Jan G., additional

Published
2022
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242. Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

Author

Remetic, Jelena, primary, Ghallab, Ahmed, additional, Hobloss, Zaynab, additional, Brackhagen, Lisa, additional, Hassan, Reham, additional, Myllys, Maiju, additional, Radun, Richard, additional, Mlitz, Veronika, additional, Zhu, Ci, additional, Baumgartner, Maximilian, additional, Schrottmaier, Waltraud C., additional, Mussbacher, Marion, additional, Timelthaler, Gerald, additional, Scharnagl, Hubert, additional, Stojakovic, Tatjana, additional, Assinger, Alice, additional, Fuchs, Claudia D., additional, Hengstler, Jan G., additional, and Trauner, Michael, additional

Published
2022
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243. Reply

Author

Vartak, Nachiket, primary and Hengstler, Jan G., additional

Published
2022
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244. Long-Term Prognostic Significance of HER2-Low and HER2-Zero in Node-Negative Breast Cancer

Author

Almstedt, Katrin, primary, Heimes, Anne-Sophie, additional, Kappenberg, Franziska, additional, Battista, Marco J., additional, Lehr, Hans-Anton, additional, Krajnak, Slavomir, additional, Lebrecht, Antje, additional, Gehrmann, Mathias, additional, Stewen, Kathrin, additional, Brenner, Walburgis, additional, Weikel, Wolfgang, additional, Rahnenführer, Jörg, additional, Hengstler, Jan G., additional, Hasenburg, Annette, additional, and Schmidt, Marcus, additional

Published
2022
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245. The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Author

Brecklinghaus, Tim, primary, Albrecht, Wiebke, additional, Kappenberg, Franziska, additional, Duda, Julia, additional, Vartak, Nachiket, additional, Edlund, Karolina, additional, Marchan, Rosemarie, additional, Ghallab, Ahmed, additional, Cadenas, Cristina, additional, Günther, Georgia, additional, Leist, Marcel, additional, Zhang, Mian, additional, Gardner, Iain, additional, Reinders, Jörg, additional, Russel, Frans GM., additional, Foster, Alison J., additional, Williams, Dominic P., additional, Damle-Vartak, Amruta, additional, Grandits, Melanie, additional, Ecker, Gerhard, additional, Kittana, Naim, additional, Rahnenführer, Jörg, additional, and Hengstler, Jan G., additional

Published
2022
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246. Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue

Author

Budelmann, Daniel, primary, Laue, Hendrik, additional, Weiss, Nick, additional, Dahmen, Uta, additional, D’Alessandro, Lorenza A., additional, Biermayer, Ina, additional, Klingmüller, Ursula, additional, Ghallab, Ahmed, additional, Hassan, Reham, additional, Begher-Tibbe, Brigitte, additional, Hengstler, Jan G., additional, and Schwen, Lars Ole, additional

Published
2022
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247. Toxicogenomics directory of chemically exposed human hepatocytes

Author

Grinberg, Marianna, Stöber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Jürgen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nüssler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, Marcel, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2014
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248. The virtual liver: state of the art and future perspectives

Author

Drasdo, Dirk, Bode, Johannes, Dahmen, Uta, Dirsch, Olaf, Dooley, Steven, Gebhardt, Rolf, Ghallab, Ahmed, Godoy, Patricio, Häussinger, Dieter, Hammad, Seddik, Hoehme, Stefan, Holzhütter, Hermann-Georg, Klingmüller, Ursula, Kuepfer, Lars, Timmer, Jens, Zerial, Marino, and Hengstler, Jan G.

Published
2014
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