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967 results on '"Helenowski, Irene"'

201. A prospective, randomised controlled trial evaluating the effectiveness of the fluid immersion simulation system vs an air‐fluidised bed system in the acute postoperative management of pressure ulcers: A midpoint study analysis

Author

Mendoza, Rafael A., primary, Lorusso, Gabriella A., additional, Ferrer, Daniela A., additional, Helenowski, Irene B., additional, Liu, Jing, additional, Soriano, Rachna H., additional, and Galiano, Robert D., additional

Published
2019
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204. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis

Author

Burt, Richard K., primary, Balabanov, Roumen, additional, Burman, Joachim, additional, Sharrack, Basil, additional, Snowden, John A., additional, Oliveira, Maria Carolina, additional, Fagius, Jan, additional, Rose, John, additional, Nelson, Flavia, additional, Barreira, Amilton Antunes, additional, Carlson, Kristina, additional, Han, Xiaoqiang, additional, Moraes, Daniela, additional, Morgan, Amy, additional, Quigley, Kathleen, additional, Yaung, Kimberly, additional, Buckley, Regan, additional, Alldredge, Carri, additional, Clendenan, Allison, additional, Calvario, Michelle A., additional, Henry, Jacquelyn, additional, Jovanovic, Borko, additional, and Helenowski, Irene B., additional

Published
2019
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206. Impact of BMI on Outcomes after Mesenteric Revascularization for Chronic Mesenteric Ischemia

Author

Mansukhani, Neel A., Hekman, Katherine E., Yoon, Dustin Y., Helenowski, Irene B., Hoel, Andrew W., Rodriguez, Heron E., Pearce, William H., Eskandari, Mark K., and Tomita, Tadaki M.

Subjects
Adult, Male, Time Factors, Comorbidity, Kaplan-Meier Estimate, Article, Body Mass Index, Veins, Blood Vessel Prosthesis Implantation, Peripheral Arterial Disease, Postoperative Complications, Risk Factors, Humans, Obesity, Renal Insufficiency, Chronic, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Endovascular Procedures, Smoking, Middle Aged, Blood Vessel Prosthesis, Treatment Outcome, Mesenteric Ischemia, Chronic Disease, Hypertension, Multivariate Analysis, Female
Abstract

OBJECTIVE: Historically, patients with chronic mesenteric ischemia (CMI) are underweight with a low body mass index (BMI). However, with the recent obesity epidemic many of these patients now are overweight with a high BMI. We evaluated the impact of BMI on outcomes after mesenteric revascularization for CMI. METHODS: A retrospective chart review of patients undergoing open or endovascular mesenteric revascularization for CMI between January 2000 and June 2015 was performed. Demographics, co-morbidities, BMI, Society for Vascular Surgery (SVS) combined co-morbidity score, treatment modality, post-operative complications, reintervention, and all-cause mortality were analyzed. The primary endpoint for the study was all-cause mortality at 5 years. Patients were stratified using World Health Organization (WHO) BMI criteria. Univariate, Kaplan-Meier (KM) survival, and multivariate analyses were performed. RESULTS: In the study period, 104 unique patients underwent mesenteric revascularization for CMI, for 77 of whom BMI information was available. Of these 77, 30 patients were treated by endovascular revascularization and 47 patients were treated by open revascularization. Overall, 27 (35.1%) were overweight or obese with a BMI ≥25. Median follow-up time was 41 months. High BMI patients were less likely to have weight loss at the time of surgery (P=0.004). Stratified by BMI

Published
2017

207. Local Transdermal Delivery of Telapristone Acetate Through Breast Skin, Compared With Oral Treatment: A Randomized Double‐Blind, Placebo‐Controlled Phase II Trial.

Author

Lee, Oukseub, Pilewskie, Melissa, Karlan, Scott, Tull, Mary B., Benante, Kelly, Xu, Yanfei, Blanco, Luis, Helenowski, Irene, Kocherginsky, Masha, Yadav, Shivangi, Hosseini, Omid, Hansen, Nora, Bethke, Kevin, Muzzio, Miguel, Troester, Melissa A., Dimond, Eileen, Perloff, Marjorie, Heckman‐Stoddard, Brandy, and Khan, Seema A.

Subjects
SKIN permeability, TANDEM mass spectrometry, ACETATES, PROGESTERONE antagonists, CANCER prevention, LIQUID chromatography, PROGESTERONE receptors
Abstract

Oral breast cancer prevention medications entail systemic exposure, limiting acceptance by high‐risk women. Delivery through the breast skin, although an attractive alternative, requires demonstration of drug distribution throughout the breast. We conducted a randomized double‐blind, placebo‐controlled phase II clinical trial comparing telapristone acetate, a progesterone receptor antagonist, administered orally (12 mg/day) or transdermally (12 mg/breast) for 4 ± 1 weeks to women planning mastectomy. Plasma and tissue concentrations, measured at five locations in the mastectomy specimen using liquid chromatography tandem mass spectrometry were compared. In 60 evaluable subjects, median drug concentration (ng/g tissue) was 103 (interquartile range (IQR): 46.3–336) in the oral vs. 2.82 (IQR: 1.4–5.5) in the transdermal group. Despite poor dermal permeation, within‐breast drug distribution pattern was identical in both groups (R2 = 0.88, P = 0.006), demonstrating that transdermally and orally delivered drug is distributed similarly through the breast, and is strongly influenced by tissue adiposity (P < 0.0001). Other skin‐penetrant drugs should be tested for breast cancer prevention. [ABSTRACT FROM AUTHOR]

Published
2021
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209. HYBRID EVAR: PRESERVATION OF PELVIC PERFUSION WITH EXTERNAL TO INTERNAL ILIAC ARTERY BYPASS

Author

Mansukhani, Neel A., Havelka, George E., Helenowski, Irene B., Rodriguez, Heron E., Hoel, Andrew W., and Eskandari, Mark K.

Subjects
Aged, 80 and over, Chicago, Male, Time Factors, Computed Tomography Angiography, Endovascular Procedures, Length of Stay, Middle Aged, Aortography, Iliac Artery, Article, Blood Vessel Prosthesis, Pelvis, Blood Vessel Prosthesis Implantation, Postoperative Complications, Treatment Outcome, Regional Blood Flow, Risk Factors, Humans, Stents, Vascular Patency, Aged, Aortic Aneurysm, Abdominal, Retrospective Studies
Abstract

Diminished pelvic arterial flow as a result of intentional coverage/embolization of internal iliac arteries (IIA) during isolated endovascular common iliac artery aneurysm (CIAA) repair or endovascular repair of abdominal aortic aneurysms (EVAR) may result in symptomatic pelvic ischemia. Although generally well tolerated, in severe cases, pelvic ischemia may manifest as recalcitrant buttock claudication, vasculogenic impotence, or perineal, vesicle, rectal, and/or spinal cord ischemia. Branched graft technology has recently become available; however, many patients are not candidates for endovascular repair with these devices. Therefore, techniques to preserve pelvic arterial flow are needed. We reviewed our outcomes of isolated endovascular CIAA repair or EVAR in conjunction with unilateral external-internal iliac artery bypass.Single-center, retrospective review of 10 consecutive patients who underwent hybrid endovascular abdominal aortic aneurysm (AAA) or CIAA repair with concomitant external-internal iliac artery bypass between 2006 and 2015. Demographics, index procedural details, postoperative symptoms, hospital length of stay (LOS), follow-up imaging, and bypass patency were recorded.The cohort of 10 patients was all men with a mean age of 71 years (range: 56-84). Hybrid repair consisted of contralateral IIA coil embolization followed by EVAR with external iliac artery-internal iliac artery (EIA-IIA) bypass. All EIA-IIA bypasses were performed via a standard lower quadrant retroperitoneal approach with a prosthetic bypass graft. Technical success was 100%, and there were no perioperative deaths. One patient developed transient paraplegia, 1 patient had buttock claudication on the side of his hypogastric embolization contralateral to his iliac bypass, and 1 developed postoperative impotence. 20% of patients sustained long-term complications (buttock claudication and postoperative impotence). Mean LOS was 2.8 days (range: 1-9 days). Postoperative imaging was obtained in 90% of patients, and mean follow-up was 10.8 months (range: 0.5-36 months). All bypasses remained patent.Although branched graft technology continues to evolve, strategies to maintain adequate pelvic circulation are necessary to avoid the devastating complications of pelvic ischemia. We have demonstrated that a hybrid approach combining EVAR or isolated endovascular common iliac artery exclusion with a unilateral external-internal iliac bypass via a retroperitoneal approach is well tolerated with a short LOS and excellent patency rates.

Published
2017

210. Atypical meningioma: Randomized trials are required to resolve contradictory retrospective results regarding the role of adjuvant radiotherapy

Author

Yoon, Hannah, Mehta, Minesh, Perumal, Karthikeyan, Helenowski, Irene, Chappell, Richard, Akture, Erinc, Lin, Yunzhi, Marymont, Mary Anne, Sejpal, Samir, Parsa, Andrew, Chandler, James, Bendok, Bernard, Rosenow, Joshua, Salamat, Shahriar, Kumthekar, Priya, Raizer, Jeffrey, and Baskaya, Mustafa

Subjects
Meningioma -- Care and treatment, Radiotherapy -- Methods, Health
Abstract

Byline: Hannah. Yoon, Minesh. Mehta, Karthikeyan. Perumal, Irene. Helenowski, Richard. Chappell, Erinc. Akture, Yunzhi. Lin, Mary Anne. Marymont, Samir. Sejpal, Andrew. Parsa, James. Chandler, Bernard. Bendok, Joshua. Rosenow, Shahriar. Salamat, [...]

Published
2015

212. Multicenter Phase II Study of Sequential Brentuximab Vedotin and Doxorubicin, Vinblastine, and Dacarbazine Chemotherapy for Older Patients With Untreated Classical Hodgkin Lymphoma

Author

Evens, Andrew M., primary, Advani, Ranjana H., additional, Helenowski, Irene B., additional, Fanale, Michelle, additional, Smith, Sonali M., additional, Jovanovic, Borko D., additional, Bociek, Gregory R., additional, Klein, Andreas K., additional, Winter, Jane N., additional, Gordon, Leo I., additional, and Hamlin, Paul A., additional

Published
2018
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217. Feasibility and accuracy of UF/NCI phantoms and Monte Carlo retrospective dosimetry in children treated on National Wilms Tumor Study protocols

Author

Kalapurakal, John A., primary, Gopalakrishnan, Mahesh, additional, Mille, Matthew, additional, Helenowski, Irene, additional, Peterson, Susan, additional, Rigsby, Cynthia, additional, Laurie, Fran, additional, Jung, Jae Won, additional, Fitzgerald, Thomas J., additional, and Lee, Choonsik, additional

Published
2018
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225. Autologous Non-Myeloablative Hematopoietic Stem Cell Transplantation in Patients with Neuromyelitis Optica Spectrum Disorder (NMOSD): An Open-Label Pilot Study

Author

Burt, Richard K., primary, Balabanov, Roumen, additional, Han, Xiaoqiang, additional, Morgan, Amy, additional, Clendenan, Allison, additional, Calvario, Michelle A., additional, Henry, Jaquelyn, additional, Quigley, Kate, additional, Gastala, Joe, additional, Jovanovic, Borko, additional, Helenowski, Irene, additional, Jitprapaikulsan, Jiraporn, additional, Fryer, James P., additional, and Pittock, Sean J., additional

Published
2018
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228. Sequential Brentuximab Vedotin (Bv) before and after Adriamycin, Vinblastine, and Dacarbazine (Bv-AVD) for Older Patients with Untreated Classical Hodgkin Lymphoma (cHL): Final Results from a Multicenter Phase II Study

Author

Evens, Andrew M, primary, Advani, Ranjana H., additional, Fanale, Michelle A., additional, Smith, Sonali M., additional, Helenowski, Irene, additional, Jovanovic, Borko, additional, Bociek, R. Gregory, additional, Klein, Andreas, additional, Winter, Jane N., additional, Gordon, Leo I., additional, and Hamlin, Paul A., additional

Published
2017
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232. c-Met Overexpression in Cervical Cancer, a Prognostic Factor and a Potential Molecular Therapeutic Target

Author

Refaat, Tamer, primary, Donnelly, Eric D., additional, Sachdev, Sean, additional, Parimi, Vamsi, additional, El Achy, Samar, additional, Dalal, Prarthana, additional, Farouk, Mohamed, additional, Berg, Natasha, additional, Helenowski, Irene, additional, Gross, Jeffrey P., additional, Lurain, John, additional, Strauss, Jonathan B., additional, Woloschak, Gayle, additional, Wei, Jian-Jun, additional, and Small, William, additional

Published
2017
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234. Additional file 1: Figure S1. of Synuclein-γ (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease

Author

Strohl, Anna, Mori, Kristina, Akers, Stacey, Wiam Bshara, Buttin, Barbara, Frederick, Peter, Helenowski, Irene, Morrison, Carl, Kunle Odunsi, Schink, Julian, Scholtens, Denise, Wei, Jian-Jun, and J. Kim

Subjects
endocrine system, female genital diseases and pregnancy complications
Abstract

Expression of SNCG mRNA in benign fallopian tube epithelium and ovarian cancer tissues. RNA from human benign fallopian tube epithelium and ovarian cancer tissues was subjected to RT-real time PCR for SNCG. SNCG as a ratio of the housekeeping gene TBP is presented using delta delta CT calculations. * = p

Published
2016
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235. Additional file 2: Table S1. of Synuclein-Îł (SNCG) expression in ovarian cancer is associated with high-risk clinicopathologic disease

Author

Strohl, Anna, Mori, Kristina, Akers, Stacey, Wiam Bshara, Buttin, Barbara, Frederick, Peter, Helenowski, Irene, Morrison, Carl, Kunle Odunsi, Schink, Julian, Scholtens, Denise, Wei, Jian-Jun, and J. Kim

Abstract

Hazard ratios (HR) from multivariate Cox regression models for PFS and OS involving SNCG expression and adjusting for relevant demographic and clinical factors. (DOCX 123Â kb)

Published
2016
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236. Cardiac safe hematopoietic stem cell transplantation for systemic sclerosis with poor cardiac function: a pilot safety study that decreases neutropenic interval to 5 days

Author

Burt, Richard K., Han, Xiaoqiang, Quigley, Kathleen, Arnautovic, Indira, Shah, Sanjiv J., Lee, Daniel C., Freed, Benjamin H., Jovanovic, Borko, and Helenowski, Irene B.

Abstract

We compared three fludarabine-based regimens for systemic sclerosis patients with a high-risk cardiac phenotype that according to EBMT criteria would be a contraindication for a high-dose cyclophosphamide (200?mg/kg) transplant regimen. All three regimens included fludarabine, ATG, and cyclophosphamide (60?mg/kg), while two regimens also included rituximab with or without IVIG. Treatment related mortality (TRM) was 2.4%. The mean number of days of neutropenia (ANC?

Published
2021
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245. Examining screening behaviors at a high-risk ovarian cancer clinic.

Author

Lynam-Scherr, Courtney, primary, Hope, Kisha T, additional, Helenowski, Irene B., additional, Kocherginsky, Masha, additional, Keene, Melissa, additional, Strohl, Anna Everett, additional, Marshall-Fricker, Charlotte, additional, Guo, Xiaoyue Mona, additional, Shahabi, Shohreh, additional, and Shulman, Lee P, additional

Published
2017
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250. Impact of use of phosphodiesterase type 5 inhibitors (PDE5-I) after radical prostatectomy (RP) on biochemical recurrence-free (BCRF) and overall survival (OS): A retrospective study from the Northwestern University SPORE in prostate cancer.

Author

Roston, Arden B., primary, Helenowski, Irene B., additional, Catalona, William, additional, Leikin, Robin, additional, Gurley, Michael, additional, Trapp, Luke, additional, Jovanovic, Borko, additional, and Kuzel, Timothy M, additional

Published
2017
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