557 results on '"Hawkins F"'
Search Results
202. THE CARBON ARC: ITS CHARACTERISTICS AND PROPERTIES.
- Author
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Hawkins, F. S.
- Abstract
The article discusses the characteristics and properties of the carbon arc based on several science experiments. Chemist Sir Humphrey Davy has demonstrated the formation of an electric arc between two pieces of burnt charcoal in 1809. An arc can be formed through hot carbon electrodes and arc gap. One method of striking the arc is through ionisation of gases in the gap between the electrodes. The formation and shape of a crater depends on the energy expended at its surface.
- Published
- 1947
203. THE DESIGN OF STUDIO LIGHTING FITTINGS.
- Author
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Hawkins, F. S. and Stevens, W. R.
- Abstract
The article discusses the factors to be considered in designing kinema studio lighting fittings. Tungsten filament lamps are used in kinema studios for black and white film while high intensity arcs are ideal for colour film. The methods of maintaining the cool temperature of body and workings parts of studio lighting unit are explored. It mentions the possible sources of noise that may occur in arc and incandescent fittings and ways to reduce or eliminate such noise.
- Published
- 1947
204. A deletion and a duplication in distal 22q11.2 deletion syndrome region. Clinical implications and review
- Author
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Fernández Luis, Nevado Julián, Santos Fernando, Heine-Suñer Damià, Martinez-Glez Victor, García-Miñaur Sixto, Palomo Rebeca, Delicado Alicia, Pajares Isidora, Palomares María, García-Guereta Luis, Valverde Eva, Hawkins Federico, and Lapunzina Pablo
- Subjects
Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Individuals affected with DiGeorge and Velocardiofacial syndromes present with both phenotypic diversity and variable expressivity. The most frequent clinical features include conotruncal congenital heart defects, velopharyngeal insufficiency, hypocalcemia and a characteristic craniofacial dysmorphism. The etiology in most patients is a 3 Mb recurrent deletion in region 22q11.2. However, cases of infrequent deletions and duplications with different sizes and locations have also been reported, generally with a milder, slightly different phenotype for duplications but with no clear genotype-phenotype correlation to date. Methods We present a 7 month-old male patient with surgically corrected ASD and multiple VSDs, and dysmorphic facial features not clearly suggestive of 22q11.2 deletion syndrome, and a newborn male infant with cleft lip and palate and upslanting palpebral fissures. Karyotype, FISH, MLPA, microsatellite markers segregation studies and SNP genotyping by array-CGH were performed in both patients and parents. Results Karyotype and FISH with probe N25 were normal for both patients. MLPA analysis detected a partial de novo 1.1 Mb deletion in one patient and a novel partial familial 0.4 Mb duplication in the other. Both of these alterations were located at a distal position within the commonly deleted region in 22q11.2. These rearrangements were confirmed and accurately characterized by microsatellite marker segregation studies and SNP array genotyping. Conclusion The phenotypic diversity found for deletions and duplications supports a lack of genotype-phenotype correlation in the vicinity of the LCRC-LCRD interval of the 22q11.2 chromosomal region, whereas the high presence of duplications in normal individuals supports their role as polymorphisms. We suggest that any hypothetical correlation between the clinical phenotype and the size and location of these alterations may be masked by other genetic and/or epigenetic modifying factors.
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- 2009
- Full Text
- View/download PDF
205. 257 A novel methodology for targeted injury and cell transplantation in the murine lower respiratory tract.
- Author
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Kohn, A., Herriges, M., Basak, P., Ma, L., Kotton, D., and Hawkins, F.
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CELL transplantation , *WOUNDS & injuries - Published
- 2024
- Full Text
- View/download PDF
206. A CHRISTMAS MESSAGE.
- Author
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Hawkins, F. S.
- Abstract
The article presents a Christmas message from F. S. Hawkins, president of the British Kinematograph Society. He shares his views on the traditional celebration of the season and how the growth of materialistic civilization has led to improvements in the arts such as photography and sound film. He also relates that the application of science in the Society centers on techniques that must be concealed from the viewing public whose presence is essential to the industry.
- Published
- 1957
207. SOME NOTES ON THE BRITISH STANDARD OF SCREEN LUMINANCE.
- Author
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Hawkins, F. S.
- Abstract
The article discusses on the British Standards specification for screen luminance in August 1947 in Great Britain. A note was contained to point out that further work was needed to enable a more comprehensive standard to be laid down the most convenient method of measurement. A photometer is used to measure the brightness of the screen, however, it was thought to be unreliable. The standards were prepared for the three dimensional and the wide screen film, it involves processes of vision
- Published
- 1953
208. Results of the Madagascar Important Bird Areas Project.
- Author
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Rakotonomenjanahary, O., Andrianarivo, C., Andriantsilavo, F., Andriantsalama, V., Faramalala, M., Hawkins, F., Rabeony, O., Rabenandrasana, M., Rahagalala, P., Raminoarisoa, V., and Razakanaivo, V.
- Subjects
ORNITHOLOGY ,BIRDS ,HABITATS - Abstract
Presents an abstract on the article 'Results of the Madagascar Important Bird Areas Project.'
- Published
- 2001
209. 270 Endobronchially harvested WT and CFTRG551D ferret bronchial epithelial cells maintain differentiation capacity and CFTR function to enable cell therapy.
- Author
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Vijaykumar, K., Tang, L., Li, Q., Pavelkova, N., Stanford, D., Suzuki, S., Ma, L., Chen, K., Berical, A., Hanafy, M., Schultz-Hildebrandt, H., Raju, S., Tearney, G., Davis, B., Kotton, D., Hawkins, F., and Rowe, S.
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CELL differentiation , *EPITHELIAL cells , *CELLULAR therapy , *CELL physiology , *FERRET - Published
- 2024
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210. 256 Primary mouse tracheal basal cells transplanted into CFTR−/− mice reconstitute CFTR function.
- Author
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Chen, K., Berical, A., Oez, H., Braga, C., Garrison, A., Gudneppanavar, R., Egan, M., Kotton, D., Bruscia, E., and Hawkins, F.
- Subjects
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MICE - Published
- 2024
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211. Bone mineral density in patients on LT4 suppressive therapy: Influence of sex and menopause
- Author
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Hawkins, F., López, M., Martínez, G., Rigopoulou, D., Jódar, E., and Larrodera, L.
- Abstract
Without Abstract:
- Published
- 1996
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212. A TRIP AMONG THE CHURCHES.
- Author
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HAWKINS, F. MAEION
- Published
- 1874
213. Delware.
- Author
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HAWKINS, F. MARION
- Published
- 1873
214. Maryland.
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HAWKINS, F. MARION
- Published
- 1873
215. Maryland Convention.
- Author
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HAWKINS, F. MARION
- Published
- 1872
216. FROM CORRESPONDENTS.
- Author
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HAYDEN, B. H., HAWKINS, F. MARION, MITCHELL, JOHN P., BINGMAN, S. H., HOUGH, M. T., GOODWIN, A. D., SCHOLL, W. C., and FRANK, JOSEPH C.
- Published
- 1872
217. FROM CORRESPONDENTS.
- Author
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AINSLIE, PETER, HAWKINS, F. MARION, FRAZIER, E. L., ROYCE, G. M., POLLY, ENOS W., HENRY, J. H., HART, E. J., JONES, Z. W., WALK, DAVID, and TYLER, B. B.
- Published
- 1871
218. REVIVALS.
- Author
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HAWKINS, F.
- Published
- 1846
219. Herkimer cir., Black River con., July 1.
- Author
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HAWKINS, F.
- Published
- 1841
220. FROM CORRESPONDENTS.
- Author
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HAWKINS, F. MARION, LONDON, C., FRIEND, J., WALKER, N. A., TILFORD, J. M., VAN BUSKIRK, D. R., COBURN, JOHN F., TYLER, B. B., CAMPBELL, GEO., and HUNSBERRY, T. H.
- Published
- 1870
221. BRITISH COMPROMISE.
- Author
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Hawkins, F. S.
- Abstract
The article focuses on the interests of the British Kinematograph Sound and Television Society in initiating activities at Christmas in Great Britain. The activities could neither be a source of strength or weakness to the society. It would strengthen when divisional activities encourage members with common interests to meet and foster their mutual aims. There is an opportunity for the genius for compromise and for a member to widen his experience by participating in the activities.
- Published
- 1956
222. EDITORIAL.
- Author
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Hawkins, F. S.
- Abstract
The author reflects on the advancements in lighting technology for the motion picture industry in Great Britain. He states that the improvements in lighting technology is a very big help for the industry particularly, in the achievement of better color balance with stocks, as well as in film making. The author acknowledges those who gave extra efforts for the advancement of the industry.
- Published
- 1960
223. DIVISIONAL ANNUAL GENERAL MEETINGS.
- Author
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Hawkins, F. S.
- Abstract
The article reports on the limited suggestions for future meetings at the divisional annual general meetings (AGM) of the British Kinematograph Sound and Television Society. The committees are tasked to arrange the meetings and members may express their ideas by coming to the divisional AGM. Specific suggestions for the subjects and lecturers persuaded to give the talk might serve the interest of the members
- Published
- 1958
224. A REMINDER FOR SUBSCRIPTIONS AND CHANGE OF ADDRESS.
- Author
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Hawkins, F. S.
- Abstract
The article presents a reminder for subscriptions to the "British Kinematography" journal. Members are advised to notify the British Kinematograph Society of any change of address to limit the high cost of postage paid by the Society. Members are also asked to complete the Banker's Order form which will be attached to the Annual subscription reminder to ensure prompt payment and regular receipt of the journal every Sunday.
- Published
- 1957
225. TAKING STOCK.
- Author
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Hawkins, F. S.
- Abstract
The author reflects on the twenty-fifth founding anniversary of the British Kinematograph Society. According to the author, the society was able to expand its activities and support its four separate divisions. Its membership now ranges from Student to Honorary Fellow. The author also recognizes the contribution of the members of the Council and Executive to the steady growth of the society.
- Published
- 1956
226. THE PROJECTIONIST TRAINING SCHEME.
- Author
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Hawkins, F. S.
- Abstract
The article offers information on a projectionist training program drawn up by the British Kinematograph Society in 1952. The article discusses the importance of a projectionist learning the fundamentals of his job to build a foundation that will enable him to operate current and future machines in the best possible way.
- Published
- 1952
227. THE EDUCATIONAL PROGRAMME.
- Author
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Hawkins, F. S.
- Abstract
The article presents information on the Lighting for Kinematography and Sensitometry, educational courses offered by the British Kinematograph, Sound and Television Society in 1951. Since the two courses were over-subscribed, similar courses are to be arranged as the first has already been repeated while the other is scheduled to be done again. The courses have been arranged for studio personnel who can attend all lectures in the London area.
- Published
- 1951
228. LIGHT CALCULATIONS AND MEASUREMENTS.
- Author
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Hawkins, F. S.
- Abstract
The article reviews the book "Light Calculations and Measurements," by H. A. E. Keitz.
- Published
- 1956
229. PRINCIPLES OF LIGHTING.
- Author
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Hawkins, F. S.
- Abstract
The article reviews the book "Principles of Lighting," by W. R. Stevens.
- Published
- 1952
230. THE HENDERSON TRUST REPORTS, NUMBERS I, II AND III.
- Author
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Hawkins, F. H.
- Subjects
TRUSTS & trustees ,NONFICTION - Abstract
Reviews the book "The Henderson Trust Reports, Numbers I, II and III," by J.F. Tocher.
- Published
- 1925
231. The effects of strontium ranelate on biochemical markers of bone turnover and their relationship with bone mineral density.
- Author
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Stepan, J., Ish-Shalom, S., Hawkins, F., Marín, F., Farrerons, J., and Kapetanos, G.
- Subjects
- *
LETTERS to the editor , *BIOMARKERS , *BONE remodeling - Abstract
A letter to the editor is presented in response to the article "Relationship Between 3-Month Changes in Biochemical Markers of Bone Remodelling and Changes in Bone Mineral Density and Fracture Incidence in Patients Treated With Strontium Ranelate for 3 Years," by O. Bruyère and colleagues in the 2009 issue.
- Published
- 2010
- Full Text
- View/download PDF
232. Serum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation.
- Author
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Martínez-Díaz-Guerra, G., Guadalix, S., Aramendi, M., Librizzi, S., García, E., Jiménez, C., and Hawkins, F.
- Subjects
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OSTEOCALCIN , *INSULIN resistance , *GLUCOSE intolerance , *LIVER transplantation , *GLUCOSE metabolism , *THERAPEUTICS - Abstract
Liver transplantation (LT) patients are at high risk of developing new-onset diabetes after transplantation (NODAT). Osteocalcin has been proposed as a mediator between bone tissue and glucose metabolism, but its role in the pathogenesis of diabetes is not defined yet. Our objective was to assess the relationship between serum osteocalcin and glucose metabolism parameters in liver transplantation recipients. A total of 187 liver transplantation patients were cross-sectionally studied, 54 of them developed NODAT. None had been diagnosed of diabetes mellitus prior to transplant. In 133 nondiabetic patients, a 75 g oral glucose tolerance test (OGTT) was performed to assess blood glucose, insulin, and C-peptide levels at baseline and 120 min. Serum total osteocalcin was measured at baseline in all patients. After OGTT, 10.5 % of LT patients had NODAT criteria, 51.9 % showed impaired glucose tolerance, and 37.6 % had normal glucose tolerance. Overall, NODAT prevalence was 36.3 %. HOMA-IR was significantly higher in NODAT compared with impaired glucose tolerance and normal glucose tolerance groups (p < 0.001). Osteocalcin was inversely correlated to HOMA-IR (r = - 0.16, p = 0.05), BMI (r = - 0.27, p = 0.000) and waist circumference (r = - 0.21, p = 0.005). Patients in the lowest osteocalcin tertile (< 16.5 ng/ml) had significantly higher fasting plasma glucose and HOMA-IR index (p = 0.029 and 0.037, respectively) than those in medium or highest tertiles. In multiple linear regression analysis, osteocalcin was negatively associated with fasting plasma glucose (standardized β coefficient - 0.16; p = 0.041) and 2-h insulin (standardized β coefficient - 0.21; p = 0.028). Prevalence of NODAT/impaired glucose tolerance is high in liver transplantation patients and is associated with insulin resistance. In these patients total osteocalcin is inversely associated with plasma glucose level and insulin resistance indexes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
233. 600 A multimodal induced pluripotent stem cell platform for cystic fibrosis drug testing.
- Author
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Berical, A., Lu, J., Lee, R., Beermann, M., Mahoney, J., Randell, S., and Hawkins, F.
- Subjects
- *
INDUCED pluripotent stem cells , *CYSTIC fibrosis , *DRUG use testing - Published
- 2022
- Full Text
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234. Denosumab compared with risedronate in postmenopausal women suboptimally adherent to alendronate therapy: Efficacy and safety results from a randomized open-label study.
- Author
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Roux, C., Hofbauer, L.C., Ho, P.R., Wark, J.D., Zillikens, M.C., Fahrleitner-Pammer, A., Hawkins, F., Micaelo, M., Minisola, S., Papaioannou, N., Stone, M., Ferreira, I., Siddhanti, S., Wagman, R.B., and Brown, J.P.
- Subjects
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THERAPEUTIC use of monoclonal antibodies , *RISEDRONATE , *COMPARATIVE studies , *OSTEOPOROSIS in women , *ALENDRONATE , *DRUG efficacy , *MEDICATION safety , *CLINICAL trials , *BONE density , *THERAPEUTICS - Abstract
Abstract: Denosumab has been shown to reduce new vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis. In subjects who were treatment-naïve or previously treated with alendronate, denosumab was associated with greater gains in bone mineral density (BMD) and decreases in bone turnover markers when compared with alendronate-treated subjects. This trial was designed to compare the efficacy and safety of denosumab with risedronate over 12months in postmenopausal women who transitioned from daily or weekly alendronate treatment and were considered to be suboptimally adherent to therapy. In this randomized, open-label study, postmenopausal women aged ≥55years received denosumab 60mg subcutaneously every 6months or risedronate 150mg orally every month for 12months. Endpoints included percentage change from baseline in total hip BMD (primary endpoint), femoral neck, and lumbar spine BMD at month 12, and percentage change from baseline in sCTX-1 at months 1 and 6. Safety was also assessed. A total of 870 subjects were randomized (435, risedronate; 435, denosumab) who had a mean (SD) age of 67.7 (6.9) years, mean (SD) BMD T-scores of −1.6 (0.9), −1.9 (0.7), and −2.2 (1.2) at the total hip, femoral neck, and lumbar spine, respectively, and median sCTX-1 of 0.3ng/mL at baseline. At month 12, denosumab significantly increased BMD compared with risedronate at the total hip (2.0% vs 0.5%), femoral neck (1.4% vs 0%), and lumbar spine (3.4% vs 1.1%; p<0.0001 at all sites). Denosumab significantly decreased sCTX-1 compared with risedronate at month 1 (median change from baseline of −78% vs −17%; p<0.0001) and month 6 (−61% vs −23%; p<0.0001). Overall and serious adverse events were similar between groups. In postmenopausal women who were suboptimally adherent to alendronate therapy, transitioning to denosumab was well tolerated and more effective than risedronate in increasing BMD and reducing bone turnover. [Copyright &y& Elsevier]
- Published
- 2014
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235. Increased Leptin/Adiponectin Ratio and Free Leptin Index Are Markers of Insulin Resistance in Obese Girls during Pubertal Development.
- Author
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Donoso, M.a., Muñoz-Calvo, M.T., Barrios, V., Martínez, G., Hawkins, F., and argente, J.
- Subjects
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ADIPONECTIN , *INSULIN resistance , *LEPTIN , *OBESITY , *PUBERTY , *CARDIOVASCULAR diseases risk factors , *HUMAN body composition , *BODY mass index - Abstract
Background: Modifications in body fat in obese patients during puberty determine changes in adipokines that affect insulin sensitivity. Aims: We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) during pubertal development. Methods: A prospective study of 32 obese girls (OG) and age-matched control girls (CG) was performed. OG were divided into those that maintained a weight loss (WL) of >1 SD of initial body mass index (BMI) (WL group, n = 25) and those without WL (NWL group, n = 7). Oral glucose tolerance tests (OGTT) were performed to evaluate IR. Correlations of adipokines, L/A, and FLI with BMI, waist circumference, percentage of TBF (%TBF) and IR were performed over pubertal development. Results: The L/A ratio and FLI were increased in OG at baseline. Both indexes decreased in the WL group as puberty progressed, with no change in CG or NWL. In the WL group, a correlation between L/A and FLI with OGTT and %TBF, and L/A and homeostasis model assessment (HOMA) was found throughout the study. Conclusion: The L/A ratio and FLI are good markers to follow changes in IR and %TBF after WL during puberty. Insulin more accurately reflects the changes in IR than HOMA. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
236. PINP en pacientes con insuficiencia hepática: Comparación de dos métodos de medida y asociación con diferentes parámetros bioquímicos.
- Author
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Guadalix, S., Martínez-Conde, L., Martínez, G. Díaz-Guerra, Vargas, C., and Hawkins, F.
- Subjects
- *
BONE densitometry , *OSTEOPOROSIS treatment , *LIVER failure , *BONE diseases , *MEDICAL research - Abstract
Summary Introduction: N-terminal propeptide of type 1 collagen (PINP) is a marker for bone formation. Blood PINP is found in trimeric and monomeric forms. There are two automated methods for its determination. ® R-PINP (Roche Diagnostics) determines both forms (Total PINP). IDS-PINP (IDS iSYS N-Mid Vitro) determines the trimeric part (Intact PINP). Objective: To compare the two methods. Material and method: 81 patients (64 men and 17 women, average age of 53 ± 8 years) with terminal hepatic insufficiency were recruited. Creatinine, PTH, 25-OH-vitamin D, beta-crosslaps (ß-CTX), desoxypyridinoline (Dpyr), hepatic function and PINP with both methods, were measured. Bone mineral ® density (BMD) was measured (Hologic , QDR 4500) in the lumbar spine and femoral neck. The comparison between the two methods was carried out using a Bland-Altman and Passing'Bablok analysis. Results: R-PINP showed higher values than IDS-PINP (85.03 ± 56.67 vs. 55.22 ± 32.81 ng/mL, p<0,001). The correlation between the two methods was r= 0.81 (p<0.01) and the Passing-Bablok regression analysis Y = 0.570 [0.475-0.669] X + 7.724 [2.130-12.542]. Conclusion: There is a good correlation between the two methods in patients with hepatic insufficiency, although not proportional or interchangeable. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
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237. Changes in serum PINP during teriparatide therapy correlate with improvements in vertebral strength as assessed by finite element modeling in men with glucocorticoid-induced osteoporosis
- Author
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⁎, P., Marin, F., Hawkins, F., Möricke, R., Ringe, J.D., Glüer, C.C., Papaioannu, N., Minisola, S., Martínez, G., Nolla, J.M., Niedhart, C., Guañabens, N., Nuti, R., Martín-Mola, E., Thomasius, F., Kapetanos, G., Peña, J., Graeff, C., Petto, H., and Gentzel, A.
- Published
- 2012
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238. Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism.
- Author
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Martos-Moreno, G Á, Kratzsch, J, Körner, A, Barrios, V, Hawkins, F, Kiess, W, and Argente, J
- Subjects
- *
CHILDHOOD obesity , *WEIGHT loss , *SERUM , *GLUCOSE , *GLUCOSE tolerance tests , *INSULIN , *INSULIN resistance , *CAUCASIAN race - Abstract
Objective:To investigate the impact of obesity, weight loss and oral glucose ingestion on serum visfatin and vaspin levels in prepubertal children.Subjects and methods:A total of 100 prepubertal obese Caucasian children (OB) and 42 controls (C) were studied. The OB group was studied at baseline and after moderate (n=46) and extensive (n=14) body mass index (BMI) reduction by conservative treatment, undergoing body composition studies (dual-energy X-ray absorptiometry) and oral glucose tolerance tests (OGTTs). Serum visfatin and vaspin levels were studied throughout the OGTT, as were their relationships with insulin, leptin, leptin soluble receptor (sOB-R), adiponectin (total and high molecular weight), resistin, interleukin-6 (IL-6) and tumor necrosis factor-α levels at every time point.Results:OB had higher visfatin (P<0.001), but similar vaspin than C. BMI reduction decreased visfatin levels (P<0.001), with BMI, waist circumference and the surrogate markers of body fat (leptin and sOB-R) showing significant correlations (P<0.05) with this peptide, but not with vaspin. Visfatin and vaspin decreased during the OGTT (P<0.001). Weight reduction did not alter visfatin dynamics in the OGTT, but decreased the area under the curve (AUC) for vaspin (P<0.001), with a correlation between the AUCs for vaspin and insulin after weight loss (P<0.05). Visfatin levels were positively correlated with resistin and IL-6, after controlling for BMI and HOMA (homeostatic model assessment) index at every time point in the study.Conclusion:Serum visfatin, but not vaspin, levels are influenced by body fat content in obese children, whereas both adipokines are modulated by glucose intake in a BMI-dependent manner. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
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239. Effect of alendronate in elderly patients after low trauma hip fracture repair.
- Author
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Cecilia, D., Jódar, E., Fernández, C., Resines, C., and Hawkins, F.
- Subjects
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BONE fractures , *FEMUR , *BONE injuries , *CALCIUM , *SURGERY , *OLDER people - Abstract
One year of once weekly alendronate, when given shortly after the surgical repair of a hip fracture, produces reductions in bone markers and increases proximal femoral bone density. The therapy was well tolerated. Hip fracture is the most devastating type of osteoporotic fracture and increases notably the risk of subsequent fractures. The aim of this paper was to evaluate the effects of 1 year therapy with a weekly dose of alendronate in the bone mineral density and bone markers in elderly patients after low trauma hip fracture repair. Two hundred thirty-nine patients (81 ± 7 years; 79.8% women) were randomized to be treated either with calcium (500 mg/daily) and vitamin D3 (400 IU/daily; Ca–Vit D group) or with alendronate (ALN, 70 mg/week) plus calcium and vitamin D3 (500 mg/daily and 400 IU/daily, respectively; ALN + Ca–Vit D group). One hundred forty-seven (61.5%) patients completed the trial. Alendronate increased proximal femoral bone mineral density (BMD) in the intention-to-treat analysis (mean difference (95% confidence interval); total hip 2.57% (0.67; 4.47); trochanteric 2.96% (0.71; 5.20), intertrochanteric 2.32% (0.36; 4.29)), but the differences were not significant in the BMD of the femoral neck (0.47%; (−2.03; 2.96) and the lumbar spine (0.69%; (−0.86; 2.23)). Bone turnover markers decreased during alendronate treatment. The present study demonstrates for the first time the anti-resorptive efficacy of alendronate given immediately after surgical repair in an elderly population with recent hip fracture. This effect should positively affect the rate of subsequent fractures. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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240. A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus.
- Author
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Herz M, Johns D, Reviriego J, Grossman LD, Godin C, Duran S, Hawkins F, Lochnan H, Escobar-Jiménez F, Hardin PA, Konkoy CS, Tan MH, and GLAB Study Group
- Abstract
OBJECTIVE: The goal of this study was to compare the effects of 2 doses of pioglitazone hydrochloride (a thiazolidinedione insulin sensitizer) with placebo on glycated hemoglobin (HbA(1c)), insulin sensitivity, and lipid profiles in patients with type 2 diabetes mellitus who had suboptimal glycemic control and mild dyslipidemia. METHODS: Patients with type 2 diabetes mellitus (HbA(1c) >/=6.5% and =9.8%) who had not previously received insulin or oral antihyperglycemic medications (OAMs) were randomized to treatment with placebo, pioglitazone 30 mg QD, or pioglitazone 45 mg QD in double-blind fashion for 16 weeks at 41 centers in Canada and Spain. RESULTS: A total of 297 patients were randomized (99 in each group). Overall, 286 (96.3%) were white. Mean (SD) age was 58.4 (10.9) years (range, 24-85 years), mean (SD) body mass index was 31.4 (4.8) kg/m(2), mean (SD) duration of type 2 diabetes mellitus was 20.0 (37.4) months, and 30.6% of patients were receiving medication for dyslipidemia. Treatment with pioglitazone 30 or 45 mg QD for 16 weeks reduced mean HbA(1c) by 0.8% and 0.9% from baseline, respectively (both P < 0.001 vs baseline and placebo). A reduction in HbA(1c) of 0.2% was observed in the placebo group (P = 0.025). In patients with medium (>/=7% to <8%) or high (>/=8% to =9.8%) baseline HbA(1c), both doses of pioglitazone significantly reduced HbA(1c) (both P < 0.001 vs placebo). Pioglitazone 30 and 45 mg significantly reduced fasting serum insulin versus placebo (P = 0.008 and P = 0.006, respectively) and increased insulin sensitivity by Homeostasis Model Assessment versus placebo (P = 0.039 and P = 0.001, respectively). Relative to placebo, pioglitazone 30 and 45 mg significantly increased high-density lipoprotein cholesterol (HDL-C [P = 0.028 and P < 0.001, respectively]) and lowered the atherogenic index of plasma (P = 0.018 and P < 0.001, respectively). Pioglitazone 45 mg also significantly reduced serum triglycerides, apolipoprotein B, and total cholesterol:HDL-C ratio versus placebo (P = 0.007, P = 0.015, and P = 0.005, respectively). Pioglitazone 30 and 45 mg were associated with a significant reduction in serum alanine aminotransferase relative to placebo (P = 0.036 and P = 0.005, respectively). Pioglitazone appeared to be safe and was well tolerated. CONCLUSIONS: In the present study, pioglitazone 30 and 45 mg produced significant improvements in HbA(1c), insulin sensitivity, and lipid profile in OAM-naive patients with type 2 diabetes mellitus with suboptimal glycemic control and mild dyslipidemia. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
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241. 639: Development of an iPSC-based toolbox to study cystic fibrosis.
- Author
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Berical, A., Beermann, M., Lee, R., LeSuer, J., Randell, S., and Hawkins, F.
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CYSTIC fibrosis - Published
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242. 675: Directed differentiation of iPS cells to an airway epithelial tissue model of CF suitable for transepithelial electrophysiology.
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Lu, J., Simpkinson, M., Stuffer, A., Harrington, J., Tabak, B., Seymour, R., Valley, H., Bell, A., Bukis, K., Coote, K., Sivachenko, A., Hawkins, F., Cotton, C., Mense, M., and Mahoney, J.
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EPITHELIUM , *INDUCED pluripotent stem cells , *CELL differentiation , *EPITHELIAL cells , *ELECTROPHYSIOLOGY - Published
- 2021
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243. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis.
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Saag KG, Emkey R, Schnitzer TJ, Brown JP, Hawkins F, Goemaere S, Thamsborg G, Liberman UA, Delmas PD, Malice M, Czachur M, Daifotis AG, and Glucocorticoid-Induced Osteoporosis Intervention Study Group
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- 1998
244. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
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D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
- Subjects
0303 health sciences ,medicine.medical_specialty ,business.industry ,EASD ,Endocrinology, Diabetes and Metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Family medicine ,Internal Medicine ,Medicine ,business ,030217 neurology & neurosurgery ,030304 developmental biology - Published
- 2004
245. Detection of soft x-ray emission from PSR 0833-45
- Author
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Hawkins, F
- Published
- 1974
- Full Text
- View/download PDF
246. X-RAY OBSERVATIONS OF CYGNUS X-3 BY COPERNICUS.
- Author
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Hawkins, F
- Published
- 1972
- Full Text
- View/download PDF
247. Whole body bone mineral density (BMD) shows a better correlation with chronological and bone age than lumbar spine BMD in prepubertal obese children
- Author
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⁎, G., Martínez, G., Argente, J., and Hawkins, F.
- Published
- 2012
- Full Text
- View/download PDF
248. Serum levels of osteocalcin and 25OH-vitamin D in patients with abnormal glucose tolerance after liver transplantation
- Author
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⁎, G., Guadalix, S., Vargas, C., García, E., Manrique, A., Partida, M., Moreno, E., and Hawkins, F.
- Published
- 2012
- Full Text
- View/download PDF
249. Teriparatide and risedronate in glucocorticoid-induced osteoporosis in men: 18-month results of the EuroGIOPS trial
- Author
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⁎, C.C., Marin, F., Ringe, J.D., Hawkins, F., Möricke, R., Papaioannu, N., Farahmand, P., Minisola, S., Martínez, G., Nolla, J.M., Niedhart, C., Guañabens, N., Nuti, R., Martín-Mola, E., Thomasius, F., Kapetanos, G., Peña, J., Graeff, C., Petto, H., and Sanz, B.
- Published
- 2012
- Full Text
- View/download PDF
250. Lumbar spine bone mineral density is influenced by bone age but not by weight loss in prepubertal obese children
- Author
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Martínez, G., Martos, G., Argente, J., and Hawkins, F.
- Published
- 2011
- Full Text
- View/download PDF
Catalog
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