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12,261 results on '"Hassoun A"'

209. Association of patient activity bio-profiles with health-related quality of life in patients with newly diagnosed multiple myeloma: a prospective observational cohort study

Author

Korde, Neha, Tavitian, Elizabet, Mastey, Donna, Lengfellner, Joseph, Hevroni, Gil, Zarski, Andrew, Salcedo, Meghan, Mailankody, Sham, Hassoun, Hani, Smith, Eric L., Hultcrantz, Malin, Shah, Urvi, Tan, Carlyn, Diamond, Benjamin, Shah, Gunjan, Scordo, Michael, Lahoud, Oscar, Chung, David J., Landau, Heather, Giralt, Sergio, Derkach, Andriy, Atkinson, Thomas M., Sabbatini, Paul, König, Francesca, Usmani, Saad Z., Landgren, Ola, and Lesokhin, Alexander M.

Published
2023
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214. List of contributors

Author

Alvarez-Fanjul, Enrique, primary, Álvarez, Marta, additional, Amores, Angel, additional, Artale, Vincenzo, additional, Barceló-Llull, Bàrbara, additional, Calafat, Francisco M., additional, Casalbore, Daniele, additional, Catalá, Teresa S., additional, Cessi, Paola, additional, Chiarella, Domenico, additional, Chiggiato, Jacopo, additional, Civitarese, Giuseppe, additional, Clementi, Emanuela, additional, Coppini, Giovanni, additional, Coppola, Laurent, additional, Cutolo, Eugenio, additional, Daniel, Pierre, additional, Delepoulle, Antoine, additional, Déverchère, Jacques, additional, Dupré, Stephanie, additional, Durrieu de Madron, Xavier, additional, Escudier, Romain, additional, Estournel, Claude, additional, Francocci, Fedra, additional, García Lafuente, Jesús, additional, Giorgi, Filippo, additional, Hassoun, Abed E.R., additional, Ibello, Valeria, additional, Josey, Simon A., additional, Korres, Gerasimos, additional, Lazzari, Paolo, additional, Lefevre, Dominique, additional, Lionello, Piero, additional, Lyubartsev, Vladyslav, additional, Macías, Diego, additional, Marcos, Marta, additional, Mason, Evan, additional, Miramontes, Elda, additional, Mourre, Baptiste, additional, Novellino, Antonio, additional, Pascual, Ananda, additional, Pellegrini, Claudio, additional, Pinardi, Nadia, additional, Ribera d’Alcalà, Maurizio, additional, Rodríguez-Tarry, Daniel, additional, Rohling, Eelco, additional, Ruiz, Simón, additional, Sannino, Gianmaria, additional, Santinelli, Chiara, additional, Schroeder, Katrin, additional, Seager, Richard, additional, Sprovieri, Mario, additional, Sánchez-Román, Antonio, additional, Tanhua, Toste, additional, Taupier-Letage, Isabelle, additional, Tintoré, Joaquín, additional, Trincardi, Fabio, additional, Ulses, Caroline, additional, Vacchi, Matteo, additional, Vargas-Yáñez, Manuel, additional, Velaoras, Dimitris, additional, Vilibić, Ivica, additional, Wöppelmann, Guy, additional, and Zodiatis, George, additional

Published
2023
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215. Detection methods of micro and nanoplastics

Author

Hassoun, Abdo, primary, Pasti, Luisa, additional, Chenet, Tatiana, additional, Rusanova, Polina, additional, Smaoui, Slim, additional, Aït-Kaddour, Abderrahmane, additional, and Bono, Gioacchino, additional

Published
2023
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216. NAIF: A novel artificial intelligence-based tool for accurate diagnosis of stage F3/F4 liver fibrosis in the general adult population, validated with three external datasets

Author

Hassoun, S, Bruckmann, C, Ciardullo, S, Perseghin, G, Marra, F, Curto, A, Arena, U, Broccolo, F, Di Gaudio, F, Hassoun, Samir, Bruckmann, Chiara, Ciardullo, Stefano, Perseghin, Gianluca, Marra, Fabio, Curto, Armando, Arena, Umberto, Broccolo, Francesco, Di Gaudio, Francesca, Hassoun, S, Bruckmann, C, Ciardullo, S, Perseghin, G, Marra, F, Curto, A, Arena, U, Broccolo, F, Di Gaudio, F, Hassoun, Samir, Bruckmann, Chiara, Ciardullo, Stefano, Perseghin, Gianluca, Marra, Fabio, Curto, Armando, Arena, Umberto, Broccolo, Francesco, and Di Gaudio, Francesca

Abstract

Objective: The purpose of this study was to determine the effectiveness of a new AI-based tool called NAIF (NAFLD-AI-Fibrosis) in identifying individuals from the general population with advanced liver fibrosis (stage F3/F4). We compared NAIF's performance to two existing risk score calculators, aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (Fib4). Methods: To set up the algorithm for diagnosing severe liver fibrosis (defined as Fibroscan® values E ≥ 9.7 KPa), we used 19 blood biochemistry parameters and two demographic parameters in a group of 5,962 individuals from the NHANES population (2017–2020 pre-pandemic, public database). We then assessed the algorithm's performance by comparing its accuracy, precision, sensitivity, specificity, and F1 score values to those of APRI and Fib4 scoring systems. Results: In a kept-out sub dataset of the NHANES population, NAIF achieved a predictive precision of 72 %, a sensitivity of 61 %, and a specificity of 77 % in correctly identifying adults (aged 18–79 years) with severe liver fibrosis. Additionally, NAIF performed well when tested with two external datasets of Italian patients with a Fibroscan® score E ≥ 9.7 kPa, and with an external dataset of patients with diagnosis of severe liver fibrosis through biopsy. Conclusions: The results of our study suggest that NAIF, using routinely available parameters, outperforms in sensitivity existing scoring methods (Fib4 and APRI) in diagnosing severe liver fibrosis, even when tested with external validation datasets. NAIF uses routinely available parameters, making it a promising tool for identifying individuals with advanced liver fibrosis from the general population. Word count abstract: 236.

Published
2024

222. Four-Port Wideband Circular Polarized MIMO Antenna for Sub-6 GHz Band

Author

Abdullah, Alyaa S., Hashem, Seham A., Al-Dayyeni, Wisam S., Mosleh, Mahmood F., Hassoun, Ihab, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Al-Emran, Mostafa, editor, Al-Sharafi, Mohammed A., editor, Al-Kabi, Mohammed N., editor, and Shaalan, Khaled, editor

Published
2022
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224. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., Bernardo, Roberto J., Vanderpool, Rebecca R., Kwon, Deborah H., Acharya, Tushar, Park, Margaret M., Katrynuik, Austin, Insel, Michael, Kubba, Saad, Badagliacca, Roberto, Larive, A. Brett, Naeije, Robert, Garcia, Joe G.N., Beck, Gerald J., Erzurum, Serpil C., Frantz, Robert P., Hassoun, Paul M., Hemnes, Anna R., Hill, Nicholas S., Horn, Evelyn M., Leopold, Jane A., Rosenzweig, Erika B., Tang, W.H. Wilson, and Wilcox, Jennifer D.

Published
2023
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225. Predicting Delayed Shock in Multisystem Inflammatory Disease in Children: A Multicenter Analysis From the New York City Tri-State Region

Author

Levine, Deborah A., Uy, Vincent, Krief, William, Bornstein, Cara, Daswani, Dina, Patel, Darshan, Kriegel, Marni, Jamal, Nazreen, Patel, Kavita, Liang, Tian, Arroyo, Alexander, Strother, Christopher, Lim, Czer Anthoney, Langhan, Melissa L., Hassoun, Ameer, Chamdawala, Haamid, Kaplan, Carl Philip, Waseem, Muhammad, Tay, Ee Tein, Mortel, David, Sivitz, Adam B., Kelly, Christopher, Lee, Horton James, Qiu, Yuqing, Gorelik, Mark, Platt, Shari L., and Dayan, Peter

Published
2023
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233. Ca2+/calmodulin‐dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model

Author

Kamilla Gömöri, Melissa Herwig, Heidi Budde, Roua Hassoun, Nusratul Mostafi, Saltanat Zhazykbayeva, Marcel Sieme, Suvasini Modi, Tamara Szabados, Judit Pipis, Nikolett Farkas‐Morvay, István Leprán, Gergely Ágoston, István Baczkó, Árpád Kovács, Andreas Mügge, Péter Ferdinandy, Anikó Görbe, Péter Bencsik, and Nazha Hamdani

Subjects
Volume‐overload, Hypertrophy, Oxidative stress, Sarcomeric proteins, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims Volume overload (VO) induced hypertrophy is one of the hallmarks to the development of heart diseases. Understanding the compensatory mechanisms involved in this process might help preventing the disease progression. Methods and results Therefore, the present study used 2 months old Wistar rats, which underwent an aortocaval fistula to develop VO‐induced hypertrophy. The animals were subdivided into four different groups, two sham operated animals served as age‐matched controls and two groups with aortocaval fistula. Echocardiography was performed prior termination after 4‐ and 8‐month. Functional and molecular changes of several sarcomeric proteins and their signalling pathways involved in the regulation and modulation of cardiomyocyte function were investigated. Results The model was characterized with preserved ejection fraction in all groups and with elevated heart/body weight ratio, left/right ventricular and atrial weight at 4‐ and 8‐month, which indicates VO‐induced hypertrophy. In addition, 8‐months groups showed increased left ventricular internal diameter during diastole, RV internal diameter, stroke volume and velocity‐time index compared with their age‐matched controls. These changes were accompanied by increased Ca2+ sensitivity and titin‐based cardiomyocyte stiffness in 8‐month VO rats compared with other groups. The altered cardiomyocyte mechanics was associated with phosphorylation deficit of sarcomeric proteins cardiac troponin I, myosin binding protein C and titin, also accompanied with impaired signalling pathways involved in phosphorylation of these sarcomeric proteins in 8‐month VO rats compared with age‐matched control group. Impaired protein phosphorylation status and dysregulated signalling pathways were associated with significant alterations in the oxidative status of both kinases CaMKII and PKG explaining by this the elevated Ca2+ sensitivity and titin‐based cardiomyocyte stiffness and perhaps the development of hypertrophy. Conclusions Our findings showed VO‐induced cardiomyocyte dysfunction via deranged phosphorylation of myofilament proteins and signalling pathways due to increased oxidative state of CaMKII and PKG and this might contribute to the development of hypertrophy.

Published
2022
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234. Working with competitors--or why co-opetition is the key to improving cost and efficiency: Today's hyper-competitive business environment calls for more advanced and innovative solutions, like sharing resources with your competitors

Author

Hassoun, Emmanuel, Mawet, Pierre, and Mack, Peter

Subjects
Logistics, Company joint venture, Business, general, Business
Abstract

When supply chain organizations are under huge pressure to improve efficiency, cost of operation and resilience, several traditional options exist: One is to transfer the cost pressure to suppliers and [...]

Published
2022

235. Development of in vitro dissolution tests for orally inhaled products

Author

Hassoun, Mireille, Forbes, Benjamin John, and Royall, Paul Garry

Abstract

Background: Dissolution testing has been proposed as a sensitive and discriminatory in vitro test for evaluating the quality or similarity of inhaled pharmaceuticals. This has led to a number of bespoke respirable particle collection and dissolution techniques being developed by academic and industrial pharmaceutical scientists. However, each comes with limitations and there is no standard or universal dissolution system for orally inhaled products. A dissolution test system would ideally reproduce conditions that represent the in vivo lung environment and would have the potential to be used for both quality control purposes and as a predictive in vitro-in vivo correlation tool. However, test systems proposed to date do not meet these criteria fully, for example many have not utilised media designed to simulate respiratory tract lung fluid (RTLF). Dissolution methodology should fulfil requirements such as simplicity, reproducibility, ease of handling, robustness and be able to discriminate differences between inhaler batch, product and formulation types. Aim: The aim of this thesis was to develop dissolution methods for OIPs by identifying the critical attributes and shortcomings of current systems and designing and evaluating improved systems using fluticasone propionate (FP) as the model drug. Methods: Two dissolution systems were evaluated: a Next Generation Impactor/Rotating paddle system and a Twin stage Impinger/Transwell® system. A novel simulated lung fluid (SLF) based on the major components of human RTLF was manufactured and characterised in terms of its physicochemical properties and stability in solution and after freeze-drying. The solubility and dissolution of inhaled drugs, including FP, were evaluated in the SLF and compared to other media. The impact of using SLF as a dissolution media was evaluated in a biorelevant dissolution system, the novel DissolvIt® system, and an in-silico PBPK model was developed and applied to evaluate the impact of in vitro data on drug pharmacokinetics and enable comparison with in vivo data. To develop the TSI/Transwell system as a biorelevant system, a Design of Experiments (DOE) approach was used to identify the influence of temperature, stirring and the solubilising capacity of dissolution media on dissolution profiles of FP. Finally, a biorelevant methodology was used to compare the dissolution of nebulised suspension and microemulsion formulations to other inhaled formulations. Results: Both dissolution systems were simple and easy to handle, producing reproducible data. Although the novel NGI/rotating paddle system was a convenient starting point for quality control purposes, the TSI/Transwell system was more amenable to development as a biorelevant technique as it was able to mimic the low fluid volume of RTLF and could be used with lung fluid simulants that are expensive and only available in limited volume. A SLF of biorelevant composition, consisting of proteins (albumin, transferrin and IgG), lipids (DPPC, DPPG and cholesterol) and antioxidants, was characterised. It was shown to possess physiochemical properties comparable to those of RTLF, such as being an isotonic solution with a physiological pH of 7.2, viscosity of 1.138 x 10-3 Pa s, conductivity of 14.5 mS/m, surface tension of 54.9 mN/m and density of 0.999 g/cm3.The simulant was stable for 24 and 48 h at 37 and 20°C and for 14 days at 4°C and when freeze-dried. A novel and sensitive solid phase extraction and LC-MS/MS technique for the assay of FP was established and validated successfully to quantify the drug in low concentrations in biological matrices, in picogram concentrations. In the DissolvIt system the use of SLF as a dissolution medium did not impact on dissolution profiles compared to the standard polymer solution (P > 0.05), but DOE using the TSI/Transwell system found solubilising capacity of the medium to be a major factor. Biorelevant conditions assigned as a dissolution medium of 0.1% w/v SDS in PBS (providing the same solubilising capacity as SLF), temperature 37°C and stirring rate 15 rpm. These biorelevant dissolution test conditions indicated that the dissolution of FP from a novel microemulsion formulation reached approximately 70% (almost double) over the 8 h experiment, compared to the dissolution of FP from the Flixotide suspension formulation (P < 0.05). Conclusion: A simulated lung fluid has been developed for use in a dissolution system tailored to orally inhaled products. The dissolution technique is sensitive to temperature, stirring and the solubilising capacity of the dissolution medium and in preliminary tests has shown promise in discriminating between different fluticasone inhaler products and formulations.

Published
2019

236. Poor Cardiac Output Reserve in Pulmonary Arterial Hypertension is Associated With Right Ventricular Stiffness and Impaired Interventricular Dependence

Author

Cubero Salazar, Ilton M., primary, Lancaster, Andrew C., additional, Jani, Vivek P., additional, Montovano, Margaret J., additional, Kauffman, Matthew, additional, Weller, Alexandra, additional, Ambale-Venkatesh, Bharath, additional, Zimmerman, Stefan L., additional, Simpson, Catherine E., additional, Kolb, Todd M., additional, Damico, Rachel L., additional, Mathai, Stephen C., additional, Mukherjee, Monica, additional, Tedford, Ryan J., additional, Hassoun, Paul M., additional, and Hsu, Steven, additional

Published
2024
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237. Colesevelam for Lenalidomide Associated Diarrhea in Patients with Multiple Myeloma

Author

Hultcrantz, Malin, primary, Hassoun, Hani, additional, Korde, Neha, additional, Maclachlan, Kylee, additional, Mailankody, Sham, additional, Patel, Dhwani, additional, Shah, Urvi, additional, Tan, Carlyn Rose, additional, Chung, David, additional, Landau, Heather, additional, Scordo, Michael, additional, Shah, Gunjan, additional, Giralt, Sergio, additional, Lahoud, Oscar, additional, Pianko, Matthew, additional, Burge, Mirande, additional, Barnett, Kelly, additional, Shekarkhand, Tala, additional, Caple, Julia, additional, Blaslov, Jenna, additional, Tran, Linh, additional, Salcedo, Meghan, additional, Hamid, Selena, additional, Nemirovsky, David, additional, Derkach, Andriy, additional, Arisa, Oluwatobi, additional, Peer, Cody, additional, Figg, William, additional, Usmani, Saad, additional, Landgren, Ola, additional, and Lesokhin, Alexander, additional

Published
2024
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238. Pulmonary hypertension across the spectrum of left heart and lung disease

Author

Borlaug, Barry A., primary, Larive, Brett, additional, Frantz, Robert P., additional, Hassoun, Paul, additional, Hemnes, Anna, additional, Horn, Evelyn, additional, Leopold, Jane, additional, Rischard, Franz, additional, Berman‐Rosenzweig, Erika, additional, Beck, Gerald, additional, Erzurum, Serpil, additional, Farha, Samar, additional, Finet, J. Emanuel, additional, Highland, Kristin B., additional, Jacob, Miriam, additional, Jellis, Christine, additional, Mehra, Reena, additional, Renapurkar, Rahul, additional, Singh, Harsimran, additional, Tang, W.H. Wilson, additional, Vanderpool, Rebecca, additional, Wilcox, Jennifer, additional, Yu, Shilin, additional, and Hill, Nicholas, additional

Published
2024
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239. Longitudinal evaluation of circulating tumor DNA (ctDNA) as a prognostic biomarker to detect minimal residual disease (MRD) in testicular cancer.

Author

Hassoun, Rebecca, primary, Ben-David, Reuben, additional, Sfakianos, John P., additional, Laliotis, George, additional, Cary, Clint, additional, Masterson, Timothy A., additional, Rivero-Hinojosa, Samuel, additional, Manage, Kevin, additional, Dutta, Punashi, additional, Tillu, Neeraja, additional, Cumarasamy, Shivaram, additional, King, Jennifer, additional, Rich, Jordan, additional, Rock, Adam, additional, Dorff, Tanya B., additional, ElNaggar, Adam, additional, Liu, Minetta C., additional, Einhorn, Lawrence H., additional, Chehrazi-Raffle, Alex, additional, and Adra, Nabil, additional

Published
2024
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242. Clinical outcomes of retreatment with daratumumab-based regimens in anti-CD38 refractory multiple myeloma.

Author

Tan, Carlyn Rose Co, primary, Rueda, Colin, additional, Shekarkhand, Tala, additional, Derkach, Andriy, additional, Korde, Neha, additional, Maclachlan, Kylee, additional, Hultcrantz, Malin, additional, Hassoun, Hani, additional, Mailankody, Sham, additional, Shah, Urvi A, additional, Rajeeve, Sridevi, additional, Lahoud, Oscar Boutros, additional, Shah, Gunjan L., additional, Scordo, Michael, additional, Chung, David J., additional, Landau, Heather Jolie, additional, Giralt, Sergio, additional, Usmani, Saad Zafar, additional, and Lesokhin, Alexander M., additional

Published
2024
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248. O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats

Author

Dupas, Thomas, primary, Vergnaud, Amandine, additional, Pelé, Thomas, additional, Blangy-Letheule, Angélique, additional, Aillerie, Virginie, additional, Bouaud, Martin, additional, Erraud, Angélique, additional, Maillard, Anaïs, additional, Hassoun, Dorian, additional, Persello, Antoine, additional, Lecomte, Jules, additional, Rivière, Matthieu, additional, Tessier, Arnaud, additional, Leroux, Aurélia A., additional, Rozec, Bertrand, additional, Denis, Manon, additional, and Lauzier, Benjamin, additional

Published
2024
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249. Postpartum obesity is associated with increases in child adiposity in mid-childhood in a cohort of Black and Dominican youth

Author

Foster, Saralyn F., primary, Rundle, Andrew G., additional, Tsai, Irene, additional, Genkinger, Jeanine M., additional, Burns, Natalie R., additional, Hoepner, Lori A., additional, Abrego, Marcela R., additional, Dube, Sara, additional, Nichols, Amy R., additional, Ramirez-Carvey, Judyth, additional, Oberfield, Sharon, additional, Hassoun, Abeer, additional, Perera, Frederica, additional, and Widen, Elizabeth M., additional

Published
2024
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