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Summary: The Committee of Scientific Advisors of International Osteoporosis Foundation (IOF) recommends that papers describing the descriptive epidemiology of osteoporosis using bone mineral density (BMD) at the femoral neck include T-scores derived from an international reference standard. Introduction: The prevalence of osteoporosis as defined by the T-score is inconsistently reported in the literature which makes comparisons between studies problematic. Methods: The Epidemiology and Quality of Life Working Group of IOF convened to make its recommendations and endorsement sought thereafter from the Committee of Scientific Advisors of IOF. Results: The Committee of Scientific Advisors of IOF recommends that papers describing the descriptive epidemiology of osteoporosis using BMD at the femoral neck include T-scores derived from the National Health and Nutrition Examination Survey III reference database for femoral neck measurements in Caucasian women aged 20–29 years. Conclusions: It is expected that the use of the reference standard will help resolve difficulties in the comparison of results between studies and the comparative assessment of new technologies. [ABSTRACT FROM AUTHOR]

A correction to the article "Management of osteoporosis of the oldest old" is presented.

An abstract of the article "The effect of maternal vitamin D concentration on fetal bone," by C. Ioannou, M. K. Javaid, P. Mahon, M. Yaqub, J. A. Noble, N. C. Harvey, K. M. Godfrey, C. Cooper, and A. T. Papageorghiou is presented.

Objective Consistent positive relationships have been found between birthweight and grip strength in young, middle-aged and older adults, suggesting that early influences on the growth and development of muscle are important for muscle function later in the lifecourse. However there are limited data in children. We aimed to assess the relationship between birthweight and grip strength in children aged 4 years. Design Prospective general population birth cohort study with data from birth to four years, drawn from the Southampton Women's Survey. Grip strength was measured using a Jamar handgrip dynamometer at age four years. We also measured height and weight and assessed body composition (lean mass) using dual energy x-ray absorptiometry. Multiple regression was used to relate grip strength to birthweight allowing for adjustment for confounding factors. Setting Southampton, UK. Participants 968 children took part in a sub-study assessing body composition and had their grip strength measured at age four years. Their socio-demographic characteristics were similar to the remainder of the cohort. Main outcome measure Grip strength in kilograms. Results Birthweight was positively associated with grip strength, with each kilogram of birthweight being associated with a 0.5 kg increase in grip strength (95% CI 0.30 to 0.70). Grip strength was also strongly related to current body size and adjustment of the birthweight relationship for height and weight attenuated the relationship such that it became non-significant with a 1kg increase in birthweight being associated with 0.15kg (95% CI -0.05 to 0.34kg) increase in grip strength. Adjustment for absolute and percentage lean mass instead of height and weight attenuated the relationship still further such that only a 0.07kg (95% CI −0.16 to 0.30) increase in grip strength was seen in relation to a 1kg increase in birthweight. Conclusion Birthweight is associated with muscle strength in children aged 4 years. Adjustment for current body size or lean mass explains the relationship suggesting that muscle size is on the causal pathway. Early influences on muscle growth and development appear to impact on grip strength in children as well as adults. [ABSTRACT FROM PUBLISHER]