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The magnetic resonance imaging (MRI) Core has been operating since Alzheimer's Disease Neuroimaging Initiative's (ADNI) inception, providing 20 years of data including reliable, multi‐platform standardized protocols, carefully curated image data, and quantitative measures provided by expert investigators. The overarching purposes of the MRI Core include: (1) optimizing and standardizing MRI acquisition methods, which have been adopted by many multicenter studies and trials worldwide and (2) providing curated images and numeric summary values from relevant MRI sequences/contrasts to the scientific community. Over time, ADNI MRI has become increasingly complex. To remain technically current, the ADNI MRI protocol has changed substantially over the past two decades. The ADNI 4 protocol contains nine different imaging types (e.g., three dimensional [3D] T1‐weighted and fluid‐attenuated inversion recovery [FLAIR]). Our view is that the ADNI MRI data are a greatly underutilized resource. The purpose of this paper is to educate the scientific community on ADNI MRI methods and content to promote greater awareness, accessibility, and use. Highlights: The MRI Core provides multi‐platform standardized protocols, carefully curated image data, and quantitative analysis by expert groups.The ADNI MRI protocol has undergone major changes over the past two decades to remain technically current.As of April 25, 2024, the following numbers of image series are available: 17,141 3D T1w; 6877 FLAIR; 3140 T2/PD; 6623 GRE; 3237 dMRI; 2846 ASL; 2968 TF‐fMRI; and 2861 HighResHippo (see Table 1 for abbreviations).As of April 25, 2024, the following numbers of quantitative analyses are available: FreeSurfer 10,997; BSI 6120; tensor based morphometry (TBM) and TBM‐SYN 12,019; WMH 9944; dMRI 1913; ASL 925; TF‐fMRI NFQ 2992; and medial temporal subregion volumes 2726 (see Table 4 for abbreviations).ADNI MRI is an underutilized resource that could be more useful to the research community. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Well‐chosen biomarkers have the potential to increase the efficiency of clinical trials and drug discovery and should show good precision as well as clinical validity. METHODS: We suggest measures that operationalize these criteria and describe a general approach that can be used for inference‐based comparisons of biomarker performance. The methods are applied to measures obtained from structural magnetic resonance imaging (MRI) from individuals with mild dementia (n = 70) or mild cognitive impairment (MCI; n = 303) enrolled in the Alzheimer's Disease Neuroimaging Initiative. RESULTS: Ventricular volume and hippocampal volume showed the best precision in detecting change over time in both individuals with MCI and with dementia. Differences in clinical validity varied by group. DISCUSSION: The methodology presented provides a standardized framework for comparison of biomarkers across modalities and across different methods used to generate similar measures and will help in the search for the most promising biomarkers. Highlights: A framework for comparison of biomarkers on pre‐defined criteria is presented.Criteria for comparison include precision in capturing change and clinical validity.Ventricular volume has high precision in change for both dementia and mild cognitive impairment (MCI) trials.Imaging measures' performance in clinical validity varies more for dementia than for MCI. [ABSTRACT FROM AUTHOR]

The goal of the Biostatistics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been to ensure that sound study designs and statistical methods are used to meet the overall goals of ADNI. We have supported the creation of a well‐validated and well‐curated longitudinal database of clinical and biomarker information on ADNI participants and helped to make this accessible and usable for researchers. We have developed a statistical methodology for characterizing the trajectories of clinical and biomarker change for ADNI participants across the spectrum from cognitively normal to dementia, including multivariate patterns and evidence for heterogeneity in cognitive aging. We have applied these methods and adapted them to improve clinical trial design. ADNI‐4 will offer us a chance to help extend these efforts to a more diverse cohort with an even richer panel of biomarker data to support better knowledge of and treatment for Alzheimer's disease and related dementias. Highlights: The Alzheimer's Disease Neuroimaging Initiative (ADNI) Biostatistics Core provides study design and analytic support to ADNI investigators.Core members develop and apply novel statistical methodology to work with ADNI data and support clinical trial design.The Core contributes to the standardization, validation, and harmonization of biomarker data.The Core serves as a resource to the wider research community to address questions related to the data and study as a whole. [ABSTRACT FROM AUTHOR]

Two fluorescent organometallic "carbene–gold(I)–acetylide" (CMAc) complexes based on bicyclic alkyl(amino) carbene (BIC), 4-ethynyl-2,1,3-benzothiadiazole (Au1) and 4,7-diethynyl-2,1,3-benzothiadiazole (Au2) have been synthesized and characterized. Compounds Au1 and Au2 exhibit blue to yellow fluorescence with up to unity fluorescence quantum yields and radiative rates exceeding 108 s−1. The dipolar Au1 complex exhibits a low two photon absorption cross-section (2PA σ2) of 0.8 GM, whereas the quadrupolar Au2 complex shows a high 2PA σ2 value of 90 GM. A fluorescent CMAc organic light emitting diode (OLED) emits blue electroluminescence with up to 4.7% external quantum efficiency. [ABSTRACT FROM AUTHOR]

Background: High/intermediate‐risk pulmonary embolism (PE) confers increased risk of cardiovascular morbidity and mortality. International guidelines recommend the formation of a PE response team (PERT) for PE management because of the complexity of risk stratification and emerging treatment options. However, there are currently no available Australian data regarding outcomes of PE managed through a PERT. Aims: To analyse the clinical and outcome data of patients from an Australian centre with high/intermediate‐risk PE requiring PERT‐guided management. Methods: We performed a retrospective observational study of 75 consecutive patients with high/intermediate‐risk PE who had PERT involvement, between August 2018 and July 2021. We recorded clinical and interventional data at the time of PERT and assessed patient outcomes up to 30 days from PERT initiation. We used unpaired t tests to compare right to left ventricular (RV/LV) ratios by computed tomography criteria or transthoracic echocardiogram (TTE) at baseline and after interventions. Results: Data were available for 74 patients. Initial computed tomography pulmonary angiography RV/LV ratio was increased at 1.65 ± 0.5 and decreased to 1.30 ± 0.29 following PERT‐guided interventions (P < 0.001). TTE RV/LV ratio also decreased following PERT‐guided management (1.09 ± 0.19 vs 0.93 ± 0.17; P < 0.001). 20% of patients had any bleeding complication, but two‐thirds were mild, not requiring intervention. All‐cause mortality was 6.8%, and all occurred within the first 7 days of admission. Conclusion: The PERT model is feasible in a large Australian centre in managing complex and time‐critical PE. Our data demonstrate outcomes comparable with existing published international PERT data. However, successful implementation at other Australian institutions may require adequate centre‐specific resource availability and the presence of multispeciality input. [ABSTRACT FROM AUTHOR]

Learning Dashboards display analytics pertaining to student performance and attainment, often alongside scores for the class cohort average. Little research has considered the effects of this social comparison information on students' well-being, motivation, and engagement. The current study presented participants with hypothetical data that simulated a student performing above, below, or at the class average before measuring self-esteem, persistence on an impossible anagram task, and willingness to engage with study support services. Our results showed that where upward social comparisons were induced (exposure to Dashboard data displaying engagement and attainment below the class average), students reported lower self-esteem than participants presented with above average vignette data. Interestingly, this effect was not moderated by the grade profile of students and no effects on persistence or willingness to engage with study support were observed. We conclude that upward social comparisons in Dashboard data can have negative consequences for students' self-esteem.

In this quasi-experimental field study, bar drinkers (0.00-0.23% blood alcohol content) viewed a photographic sequence in which a male took a laptop from a helpdesk assistant, either on loan or at gunpoint. Following a brief retention period, participants answered 20 multiple-choice questions about the male, his actions, and details of the scene, then attempted to identify him from a simultaneous target-present or target-absent line-up. Alcohol was associated with a reduction in correct identifications and an increase in false identifications. Surprisingly, the presence of a weapon in the scene enhanced identification accuracy, though wider scene memory was not influenced by alcohol or the weapon. Findings offer some support for the view that alcohol restricts face encoding, perhaps through the narrowing of attention to salient external features (e.g., hair). We also suggest that curiosity about mock-crime perpetrators may produce weapon focus reversals, although the factors that might elicit such curiosity remain unclear.

In this study, we aimed to understand the state of school grounds across Britain and how they are being used to support biodiversity conservation and pupils' environmental education. We carried out an opt-in survey of schools across Britain, asking staff to report on habitats in their grounds and how they are used for learning. Our results showed that schools are under-using their grounds to provide habitats and environmental education. Realizing the potential of these spaces could be a vital tool in the future success of species diversity. This could be done through changes to the national curricula and teacher training.

Over the last few decades, the pyrethroid insecticide bifenthrin has been increasingly employed for pest control in urban and agricultural areas, putting humans and wildlife at increased risk of exposure. Exposures to nanomolar (nM) concentrations of bifenthrin have recently been reported to alter calcium oscillations in rodent neurons. Neuronal calcium oscillations are influenced by ryanodine receptor (RyR) activity, which modulates calcium-dependent signaling cascades, including the mechanistic target of rapamycin (mTOR) signaling pathway. RyR activity and mTOR signaling play critical roles in regulating neurodevelopmental processes. However, whether environmentally relevant levels of bifenthrin alter RyR or mTOR signaling pathways to influence neurodevelopment has not been addressed. Therefore, our main objectives in this study were to examine the transcriptomic responses of genes involved in RyR and mTOR signaling pathways in zebrafish (Danio rerio) exposed to low (ng/L) concentrations of bifenthrin, and to assess the potential functional consequences by measuring locomotor responses to external stimuli. Wildtype zebrafish were exposed for 1, 3 and 5 days to 1, 10 and 50 ng/L bifenthrin, followed by a 14 d recovery period. Bifenthrin elicited significant concentration-dependent transcriptional responses in the majority of genes examined in both signaling cascades, and at all time points examined during the acute exposure period (1, 3, and 5 days post fertilization; dpf), and at the post recovery assessment time point (19 dpf). Changes in locomotor behavior were not evident during the acute exposure period, but were observed at 19 dpf, with main effects (increased locomotor behavior) detected in fish exposed developmentally to bifenthrin at 1 or 10 ng/L, but not 50 ng/L. These findings illustrate significant influences of developmental exposures to low (ng/L) concentrations of bifenthrin on neurodevelopmental processes in zebrafish.

Current treatments for seizures induced by organophosphates do not protect sufficiently against progressive neurodegeneration or delayed cognitive impairment. Developing more effective therapeutic approaches has been challenging because the pathogenesis of these delayed consequences is poorly defined. Using magnetic resonance imaging (MRI), we previously reported brain lesions that persist for months in a rat model of acute intoxication with the OP, diisopropylfluorophosphate (DFP). However, the early spatiotemporal progression of these lesions remains unknown. To address this data gap, we used in vivo MRI to longitudinally monitor brain lesions during the first 3 d following acute DFP intoxication. Adult male Sprague Dawley rats acutely intoxicated with DFP (4mg/kg, sc) were MR imaged at 6, 12, 18, 24, 48, 72h post-DFP, and their brains then taken for correlative histology to assess neurodegeneration using FluoroJade C (FJC) staining. Acute DFP intoxication elicited moderate-to-severe seizure activity. T2-weighted (T2w) anatomic imaging revealed prominent lesions within the thalamus, piriform cortex, cerebral cortex, hippocampus, corpus striatum, and substantia nigra that corresponded to neurodegeneration, evident as bands of FJC positive cells. Semi-quantitative assessment of lesion severity demonstrated significant regional variation in the onset and progression of injury, and suggested that lesion severity may be modulated by isoflurane anesthesia. These results imply that the timing of therapeutic intervention for attenuating brain injury following OP intoxication may be regionally dependent, and that longitudinal assessment of OP-induced damage by MRI may be a powerful tool for assessing therapeutic response.

ObjectiveBehavioral therapies are first-line for preschoolers with attention-deficit hyperactivity disorder (ADHD). Studies support yoga for school-aged children with ADHD; this study evaluated yoga in preschoolers on parent- and teacher-rated attention/challenging behaviors, attentional control (Kinder Test of Attentional Performance [KiTAP]), and heart rate variability (HRV).MethodsThis randomized waitlist-controlled trial tested a 6-week yoga intervention in preschoolers with ≥4 ADHD symptoms on the ADHD Rating Scale-IV Preschool Version. Group 1 (n = 12) practiced yoga first; Group 2 (n = 11) practiced yoga second. We collected data at 4 time points: baseline, T1 (6 weeks), T2 (12 weeks), and follow-up (3 months after T2).ResultsAt baseline, there were no significant differences between groups. At T1, Group 1 had faster reaction times on the KiTAP go/no-go task (p = 0.01, 95% confidence interval [CI], -371.1 to -59.1, d = -1.7), fewer distractibility errors of omission (p = 0.009, 95% CI, -14.2 to -2.3, d = -1.5), and more commission errors (p = 0.02, 95% CI, 1.4-14.8, d = 1.3) than Group 2. Children in Group 1 with more severe symptoms at baseline showed improvement at T1 versus control on parent-rated Strengths and Difficulties Questionnaire hyperactivity inattention (β = -2.1, p = 0.04, 95% CI, -4.0 to -0.1) and inattention on the ADHD Rating Scale (β = -4.4, p = 0.02, 95% CI, -7.9 to -0.9). HRV measures did not differ between groups.ConclusionYoga was associated with modest improvements on an objective measure of attention (KiTAP) and selective improvements on parent ratings.

PurposeThis study examined cross-sectional age-related trajectories of expressive language variables (syntactic complexity, lexical diversity, unintelligibility, dysfluency, and talkativeness) derived from a narrative language sampling procedure.MethodNarrative samples were analyzed from 103 typically developing individuals, ages 4-21 years.ResultsResults showed that this procedure was effective for the entire age range, with participants producing an utterance on virtually every page of the wordless picture books used to prompt the narrative. Importantly, the cross-sectional trajectories for syntactic complexity and lexical diversity showed age-related increases through the age of 18 years, although measures of other dimensions of language showed different relationships with age.ConclusionsThese data inform developmental work and document the extent to which the narrative procedure can be used to characterize expressive language over a wide age range. This procedure has been proposed as an outcome measure for clinical trials and interventions involving individuals with intellectual and developmental disabilities. The present data document the developmental levels for which the procedure and metrics derived are appropriate.

This study investigates the global response of the midlatitude atmospheric circulation to 1.5 and 2.0g°C of warming using the HAPPI (Half a degree Additional warming, Prognosis and Projected Impacts) ensemble, with a focus on the winter season. Characterising and understanding this response is critical for accurately assessing the near-term regional impacts of climate change and the benefits of limiting warming to 1.5g°C above pre-industrial levels, as advocated by the Paris Agreement of the United Nations Framework Convention on Climate Change (UNFCCC). The HAPPI experimental design allows an assessment of uncertainty in the circulation response due to model dependence and internal variability. Internal variability is found to dominate the multi-model mean response of the jet streams, storm tracks, and stationary waves across most of the midlatitudes; larger signals in these features are mostly consistent with those seen in more strongly forced warming scenarios. Signals that emerge in the 1.5g°C experiment are a weakening of storm activity over North America, an inland shift of the North American stationary ridge, an equatorward shift of the North Pacific jet exit, and an equatorward intensification of the South Pacific jet. Signals that emerge under an additional 0.5g°C of warming include a poleward shift of the North Atlantic jet exit, an eastward extension of the North Atlantic storm track, and an intensification on the flanks of the Southern Hemisphere storm track. Case studies explore the implications of these circulation responses for precipitation impacts in the Mediterranean, in western Europe, and on the North American west coast, paying particular attention to possible outcomes at the tails of the response distributions. For example, the projected weakening of the Mediterranean storm track emerges in the 2g°C warmer world, with exceptionally dry decades becoming 5 times more likely.