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2,369 results on '"Hartmann, Christian"'

205. ATRT-07. Low-grade diffusely infiltrative tumor, SMARCB1-mutant: a clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC

Author

Thomas, Christian, primary, Federico, Aniello, additional, Bens, Susanne, additional, Hellström, Mats, additional, Casar-Borota, Olivera, additional, Kordes, Uwe, additional, Neumann, Julia E, additional, Dottermusch, Matthias, additional, Rodriguez, Fausto E, additional, Lo, Andrea C, additional, Cheng, Sylvia, additional, Hendson, Glenda, additional, Hukin, Juliette, additional, Hartmann, Christian, additional, Koch, Arend, additional, Capper, David, additional, Siebert, Reiner, additional, Paulus, Werner, additional, Nemes, Karolina, additional, Johann, Pascal D, additional, Frühwald, Michael C, additional, Kool, Marcel, additional, and Hasselblatt, Martin, additional

Published
2022
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206. MEDB-04. Young children with metastatic medulloblastoma: frequent requirement for radiotherapy in children with non-WNT/non-SHH medulloblastoma despite highly intensified chemotherapy – Results of the MET-HIT2000-BIS4 trial

Author

Mynarek, Martin, primary, Goschzik, Tobias, additional, Kool, Marcel, additional, von Hoff, Katja, additional, Ottensmeier, Holger, additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Sill, Martin, additional, Rushing, Elisabeth Jane, additional, Hasselblatt, Martin, additional, Koch, Arend, additional, Schüller, Ulrich, additional, von Deimling, Andreas, additional, Riemenschneider, Markus J, additional, Dohmen, Hildegard, additional, Monoranu, Camelia-Maria, additional, Sommer, Clemens, additional, Staszewski, Ori, additional, Mawrin, Christian, additional, Schittenhelm, Jens, additional, Brück, Wolfgang, additional, Filipski, Katharina, additional, Hartmann, Christian, additional, Meinhardt, Matthias, additional, Pietschmann, Klaus, additional, Haberler, Christine, additional, Slavc, Irene, additional, Gerber, Nicolas U, additional, Grotzer, Michael, additional, Benesch, Martin, additional, Schlegel, Paul-Gerhardt, additional, Deinlein, Frank, additional, Bode, Udo, additional, von Bueren, André O, additional, Friedrich, Carsten, additional, Obrecht, Denise, additional, Fleischhack, Gudrun, additional, Kwiecien, Robert, additional, Faldum, Andreas, additional, Kortmann, Rolf-Dieter, additional, Pietsch, Torsten, additional, Pfister, Stefan, additional, and Rutkowski, Stefan, additional

Published
2022
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210. Additional file 1 of Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC

Author

Dimitriadis, Konstantinos, Meis, Jan, Neugebauer, Hermann, Barlinn, Kristian, Neumann, Bernhard, Gahn, Georg, Lochner, Piergiorgio, Knier, Benjamin, Lindemann, Sarah, Sühs, Kurt Wolfram, Szabo, Kristina, Pfefferkorn, Thomas, Schirotzek, Ingo, Freilinger, Tobias, Burc, Bassa, Günther, Albrecht, Wittstock, Matthias, Schramm, Patrick, Reimann, Gernot, Godau, Jana, Nagy, Gabor, Koenig, Fatima B., Essig, Fabian, Klinker, Hartwig, Hartmann, Christian, Schmidbauer, Moritz L., Steinberg, Tim, Lefterova, Lora, Klose, Christina, and Bösel, Julian

Abstract

Additional file 1. Additional information on Methods (list of parameters listed in the eCRF, list of categories of disorders and underlying diseases, definitions and statistics. Supplement Table 1: Neurologic past medical history according to disease categories (multiple answers possible). Supplement Table 2: PANDEMIC inclusion criteria and COVID state of disease according to disease categories (multiple answers possible). Supplement Table 3: Neurologic symptoms according to disease categories in 392 patients (multiple answers possible). Supplement Table 4: Diagnostic findings in 392 patients (multiple answers possible). Supplement Table 5: Factors influencing the occurrence of a disease category. Supplement Table 6: Factors influencing the occurrence of most common diseases. Supplement Table 7: Factors influencing the decision to therapy limitation.

Published
2022
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217. A JAM-A–tetraspanin–αvβ5 integrin complex regulates contact inhibition of locomotion

Author

Kummer, Daniel, primary, Steinbacher, Tim, additional, Thölmann, Sonja, additional, Schwietzer, Mariel Flavia, additional, Hartmann, Christian, additional, Horenkamp, Simone, additional, Demuth, Sabrina, additional, Peddibhotla, Swetha S.D., additional, Brinkmann, Frauke, additional, Kemper, Björn, additional, Schnekenburger, Jürgen, additional, Brandt, Matthias, additional, Betz, Timo, additional, Liashkovich, Ivan, additional, Kouzel, Ivan U., additional, Shahin, Victor, additional, Corvaia, Nathalie, additional, Rottner, Klemens, additional, Tarbashevich, Katsiaryna, additional, Raz, Erez, additional, Greune, Lilo, additional, Schmidt, M. Alexander, additional, Gerke, Volker, additional, and Ebnet, Klaus, additional

Published
2022
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220. Differences in the MRI Signature and ADC Values of Diffuse Midline Gliomas with H3 K27M Mutation Compared to Midline Glioblastomas

Author

Raab, Peter, primary, Banan, Rouzbeh, additional, Akbarian, Arash, additional, Esmaeilzadeh, Majid, additional, Samii, Madjid, additional, Samii, Amir, additional, Bertalanffy, Helmut, additional, Lehmann, Ulrich, additional, Krauss, Joachim K., additional, Lanfermann, Heinrich, additional, Hartmann, Christian, additional, and Brüning, Roland, additional

Published
2022
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221. Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT‐MYC

Author

Hasselblatt, Martin, primary, Thomas, Christian, additional, Federico, Aniello, additional, Bens, Susanne, additional, Hellström, Mats, additional, Casar‐Borota, Olivera, additional, Kordes, Uwe, additional, Neumann, Julia E., additional, Dottermusch, Matthias, additional, Rodriguez, Fausto J., additional, Lo, Andrea C., additional, Cheng, Sylvia, additional, Hendson, Glenda, additional, Hukin, Juliette, additional, Hartmann, Christian, additional, Koch, Arend, additional, Capper, David, additional, Siebert, Reiner, additional, Paulus, Werner, additional, Nemes, Karolina, additional, Johann, Pascal D., additional, Frühwald, Michael C., additional, and Kool, Marcel, additional

Published
2022
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223. Team Prenotification Reduces Procedure Times for Patients With Acute Ischemic Stroke Due to Large Vessel Occlusion Who Are Transferred for Endovascular Therapy

Author

Pallesen, Lars-Peder, primary, Winzer, Simon, additional, Hartmann, Christian, additional, Kuhn, Matthias, additional, Gerber, Johannes C., additional, Theilen, Hermann, additional, Hädrich, Kevin, additional, Siepmann, Timo, additional, Barlinn, Kristian, additional, Rahmig, Jan, additional, Linn, Jennifer, additional, Barlinn, Jessica, additional, and Puetz, Volker, additional

Published
2022
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224. Rare germline variants in the tumor suppressor gene CDH1 in glioma families and gastric cancer families with brain tumors

Author

Weber, Ruthild G., primary, Foerster, Alisa, additional, Banan, Rouzbeh, additional, Hueneburg, Robert, additional, Weber, Christine A. M., additional, Ewert, Wiebke, additional, Kronenberg, Jessica, additional, Elyan, Natalie, additional, Beyer, Ulrike, additional, Martens, Helge, additional, Erbersdobler, Andreas, additional, Krauss, Joachim K., additional, Stangel, Martin, additional, Samii, Amir, additional, Wolf, Stephan, additional, Preller, Matthias, additional, Aretz, Stefan, additional, Wiese, Bettina, additional, Hartmann, Christian, additional, and Brand, Frank, additional

Published
2022
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227. Spatial and temporal changes of outdoor thermal stress: influence of urban land cover types

Author

Rahman, Mohammad A., Franceschi, Eleonora, Pattnaik, Nayanesh, Moser-Reischl, Astrid, Hartmann, Christian, Paeth, Heiko, Pretzsch, Hans, Rötzer, Thomas, and Pauleit, Stephan

Subjects
Environmental impact, Multidisciplinary, Science, Medicine, ddc:630, Plant ecology, Article, ddc
Abstract

Green infrastructure (GI) has emerged as a feasible strategy for promoting adaptive capacities of cities to climate change by alleviating urban heat island (UHI) and thus heat stress for humans. However, GI can also intensify the winter cold stress. To understand the extent of UHI within a city as well as the link between outdoor thermal stress both diurnally and seasonally, we carried out an empirical study in Würzburg, Germany from 2018 to 2020. At sub-urban sites, relative humidity and wind speed (WS) was considerably higher and air temperature (AT) lower compared to the inner city sites. Mean AT of inner city sites were higher by 1.3 °C during summer and 5 °C during winter compared to sub-urban sites. The magnitude followed the spatial land use patterns, in particular the amount of buildings. Consequently, out of 97 hot days (AT > 30 °C) in 3 years, 9 days above the extreme threshold of wet bulb globe temperature of 35 °C were recorded at a centre location compared to none at a sub-urban site. Extreme heat stress could be halved with 30–40% cover of greenspaces including grass lawns, green roofs, and green walls with little compromise in increasing winter cold stress.

Published
2021

228. Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

Author

Wiestler, Benedikt, Capper, David, Sill, Martin, Jones, David T. W., Hovestadt, Volker, Sturm, Dominik, Koelsche, Christian, Bertoni, Anna, Schweizer, Leonille, Korshunov, Andrey, Weiß, Elisa K., Schliesser, Maximilian G., Radbruch, Alexander, Herold-Mende, Christel, Roth, Patrick, Unterberg, Andreas, Hartmann, Christian, Pietsch, Torsten, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard, Platten, Michael, Pfister, Stefan M., von Deimling, Andreas, Weller, Michael, and Wick, Wolfgang

Published
2014
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231. Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms

Author

Reuss, David E., Habel, Antje, Hagenlocher, Christian, Mucha, Jana, Ackermann, Ulrike, Tessmer, Claudia, Meyer, Jochen, Capper, David, Moldenhauer, Gerhard, Mautner, Victor, Frappart, Pierre-Olivier, Schittenhelm, Jens, Hartmann, Christian, Hagel, Christian, Katenkamp, Kathrin, Petersen, Iver, Mechtersheimer, Gunhild, and von Deimling, Andreas

Published
2014
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232. LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients

Author

Mock, Andreas, Geisenberger, Christoph, Orlik, Christian, Warta, Rolf, Schwager, Christian, Jungk, Christine, Dutruel, Céline, Geiselhart, Lea, Weichenhan, Dieter, Zucknick, Manuela, Nied, Ann-Katrin, Friauf, Sara, Exner, Janina, Capper, David, Hartmann, Christian, Lahrmann, Bernd, Grabe, Niels, Debus, Jürgen, von Deimling, Andreas, Popanda, Odilia, Plass, Christoph, Unterberg, Andreas, Abdollahi, Amir, Schmezer, Peter, and Herold-Mende, Christel

Published
2016
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239. Oligosarcomas, IDH-mutant are distinct and aggressive

Author

Suwala, Abigail K., primary, Felix, Marius, additional, Friedel, Dennis, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Hinz, Felix, additional, Hewer, Ekkehard, additional, Schweizer, Leonille, additional, Dohmen, Hildegard, additional, Pohl, Ute, additional, Staszewski, Ori, additional, Korshunov, Andrey, additional, Stein, Marco, additional, Wongsurawat, Thidathip, additional, Cheunsuacchon, Pornsuk, additional, Sathornsumetee, Sith, additional, Koelsche, Christian, additional, Turner, Clinton, additional, Le Rhun, Emilie, additional, Mühlebner, Angelika, additional, Schucht, Philippe, additional, Özduman, Koray, additional, Ono, Takahiro, additional, Shimizu, Hiroaki, additional, Prinz, Marco, additional, Acker, Till, additional, Herold-Mende, Christel, additional, Kessler, Tobias, additional, Wick, Wolfgang, additional, Capper, David, additional, Wesseling, Pieter, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Hartmann, Christian, additional, and Reuss, David E., additional

Published
2021
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241. Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany

Author

Frank, Christina, primary, Wickel, Jonathan, additional, Brämer, Dirk, additional, Matschke, Jakob, additional, Ibe, Richard, additional, Gazivoda, Caroline, additional, Günther, Albrecht, additional, Hartmann, Christian, additional, Rehn, Kordt, additional, Cadar, Daniel, additional, Mayer, Thomas E., additional, Pörtner, Kirsten, additional, Wilking, Hendrik, additional, Schmidt-Chanasit, Jonas, additional, and Tappe, Dennis, additional

Published
2021
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243. Multicenter Validation of Individual Preoperative Motor Outcome Prediction for Deep Brain Stimulation in Parkinson’s Disease

Author

Habets, Jeroen G.V., primary, Herff, Christian, additional, Fasano, Alfonso A., additional, Beudel, Martijn, additional, Kocabicak, Ersoy, additional, Schnitzler, Alfons, additional, Snineh, Muneer Abu, additional, Kalia, Suneil K., additional, Ramirez-Gómez, Carolina, additional, Hodaie, Mojgan, additional, Munhoz, Renato P., additional, Rouleau, Eline, additional, Yildiz, Onur, additional, Linetsky, Eduard, additional, Schuurman, Rick, additional, Hartmann, Christian J., additional, Lozano, Andres M., additional, De Bie, Rob M.A., additional, Temel, Yasin, additional, and Janssen, Marcus L.F., additional

Published
2021
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244. PATH-23. OLIGOSARCOMA, IDH-MUTANT IS A DISTINCT AGGRESSIVE TYPE

Author

Suwala, Abigail K, primary, Felix, Marius, additional, Friedel, Dennis, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Hewer, Ekkehard, additional, Schweizer, Leonille, additional, Dohmen, Hildegard, additional, Pohl, Ute, additional, Erny, Daniel, additional, Koelsche, Christian, additional, Turner, Clinton, additional, Özduman, Koray, additional, Prinz, Marco, additional, Acker, Till, additional, Herold-Mende, Christel, additional, Wick, Wolfgang, additional, Capper, David, additional, Wesseling, Pieter, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Hartmann, Christian, additional, and Reuss, David, additional

Published
2021
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246. DNA methylation-based classification of central nervous system tumours

Author

Capper, David, Jones, David T. W., Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W., Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K., Coras, Roland, Hlsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jrgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brck, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hnggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mhleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G., Driever, Pablo Herniz, Kramm, Christof M., Mller, Hermann L., Rutkowski, Stefan, von Hoff, Katja, Frhwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, Jones, Chris, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael, Collins, Vincent Peter, Blmcke, Ingmar, Bendszus, Martin, Debus, Jrgen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane, Ryzhova, Marina, Platten, Michael, Unterberg, Andreas, Wick, Wolfgang, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija, Brandner, Sebastian, Korshunov, Andrey, von Deimling, Andreas, and Pfister, Stefan M.

Subjects
Cancer diagnosis -- Methods, Methylation -- Observations, DNA sequencing -- Methods, Tumors -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challengingwith substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology., Author(s): David Capper [1, 2, 3, 4]; David T. W. Jones [5, 6]; Martin Sill [5, 6, 7]; Volker Hovestadt [8]; Daniel Schrimpf [1, 2]; Dominik Sturm [5, 6, 9]; [...]

Published
2018
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249. TMIGD1: Emerging functions of a tumor supressor and adhesion receptor

Author

Thüring, Eva-Maria, Hartmann, Christian, Schwietzer, Ysabel A., and Ebnet, Klaus

Abstract

The development of multicellular organisms depends on cell adhesion molecules (CAMs) that connect cells to build tissues. The immunoglobulin superfamily (IgSF) constitutes one of the largest families of CAMs. Members of this family regulate such diverse processes like synapse formation, spermatogenesis, leukocyte-endothelial interactions, or epithelial cell-cell adhesion. Through their extracellular domains, they undergo homophilic and heterophilic interactions in cis and trans. Their cytoplasmic domains frequently bind scaffolding proteins to assemble signaling complexes. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a IgSF member with two Ig-like domains and a short cytoplasmic tail that contains a PDZ domain-binding motif. Recent observations indicate that TMIGD1 has pleiotropic functions in epithelial cells and has a critical role in suppressing malignant cell behavior. Here, we review the molecular characteristics of TMIGD1, its interaction with cytoplasmic scaffolding proteins, the regulation of its expression, and its downregulation in colorectal and renal cancers.

Published
2023
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