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192,797 results on '"Harper, A."'

203. ExoGemS High-Resolution Transmission Spectroscopy of WASP-76b with GRACES

Author

Deibert, Emily K., de Mooij, Ernst J. W., Jayawardhana, Ray, Turner, Jake D., Ridden-Harper, Andrew, Hood, Callie E., Fortney, Jonathan J., Flagg, Laura, Fossati, Luca, Allart, Romain, Brogi, Matteo, and MacDonald, Ryan J.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present high-resolution transmission spectroscopy of WASP-76b with GRACES/Gemini North obtained as part of the ExoGemS survey. With a broad spectral range of 400-1050 nm and a relatively high resolution of ~66,000, these observations are particularly well-suited to searching for atomic and molecular atmospheric species via the Doppler cross-correlation technique. We recover absorption features due to neutral iron (Fe I), sodium (Na I), and ionized calcium (Ca II) at high significance (>5$\sigma$), and investigate possible atmospheric temperatures and wind speeds. We also report tentative (>3$\sigma$) detections of Li I, K I, Cr I, and V I in the atmosphere of WASP-76b. Finally, we report non-detections of a number of other species, some of which have previously been detected with other instruments. Through model injection/recovery tests, we demonstrate that many of these species are not expected to be detected in our observations. These results allow us to place GRACES and the ExoGemS survey in context with other high-resolution optical spectrographs., Comment: 33 pages, 31 figures. Accepted for publication in The Astronomical Journal

Published
2023

204. Characterizing non-Markovian Quantum Process by Fast Bayesian Tomography

Author

Su, R. Y., Huang, J. Y., Stuyck, N. Dumoulin., Feng, M. K., Gilbert, W., Evans, T. J., Lim, W. H., Hudson, F. E., Chan, K. W., Huang, W., Itoh, Kohei M., Harper, R., Bartlett, S. D., Yang, C. H., Laucht, A., Saraiva, A., Tanttu, T., and Dzurak, A. S.

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

To push gate performance to levels beyond the thresholds for quantum error correction, it is important to characterize the error sources occurring on quantum gates. However, the characterization of non-Markovian error poses a challenge to current quantum process tomography techniques. Fast Bayesian Tomography (FBT) is a self-consistent gate set tomography protocol that can be bootstrapped from earlier characterization knowledge and be updated in real-time with arbitrary gate sequences. Here we demonstrate how FBT allows for the characterization of key non-Markovian error processes. We introduce two experimental protocols for FBT to diagnose the non-Markovian behavior of two-qubit systems on silicon quantum dots. To increase the efficiency and scalability of the experiment-analysis loop, we develop an online FBT software stack. To reduce experiment cost and analysis time, we also introduce a native readout method and warm boot strategy. Our results demonstrate that FBT is a useful tool for probing non-Markovian errors that can be detrimental to the ultimate realization of fault-tolerant operation on quantum computing.

Published
2023

205. A Comprehensive Investigation of Gamma-Ray Burst Afterglows Detected by TESS

Author

Roxburgh, Hugh, Ridden-Harper, Ryan, Lane, Zachary G., Rest, Armin, Hubley, Lancia, Hounsell, Rebekah, Wang, Qinan, Gomez, Sebastian, Guolo, Muryel, Rest, Sofia, and von Coelln, Sophie

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Gamma-ray bursts produce afterglows that can be observed across the electromagnetic spectrum and can provide insight into the nature of their progenitors. While most telescopes that observe afterglows are designed to rapidly react to trigger information, the Transiting Exoplanet Survey Satellite (TESS) continuously monitors sections of the sky at cadences between 30 minutes and 200 seconds. This provides TESS with the capability of serendipitously observing the optical afterglow of GRBs. We conduct the first extensive search for afterglows of known GRBs in archival TESS data reduced with the TESSreduce package, and detect 11 candidate signals that are temporally coincident with reported burst times. We classify 3 of these as high-likelihood GRB afterglows previously unknown to have been detected by TESS, one of which has no other afterglow detection reported on the Gamma-ray Coordinates Network. We classify 5 candidates as tentative and the remainder as unlikely. Using the afterglowpy package, we model each of the candidate light curves with a Gaussian and a top hat model to estimate burst parameters; we find that a mean time delay of $740\pm690\,$s between the explosion and afterglow onset is required to perform these fits. The high cadence and large field of view make TESS a powerful instrument for localising GRBs, with the potential to observe afterglows in cases when no other backup photometry is possible., Comment: 17 pages, 7 figures, 5 tables

Published
2023

206. ExoGemS Detection of a Metal Hydride in an Exoplanet Atmosphere

Author

Flagg, Laura, Turner, Jake D., Deibert, Emily, Ridden-Harper, Andrew, de Mooij, Ernst, MacDonald, Ryan J., Jayawardhana, Ray, Gibson, Neale, Langeveld, Adam, and Sing, David

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Exoplanet atmosphere studies are often enriched by synergies with brown dwarf analogs. However, many key molecules commonly seen in brown dwarfs have yet to be confirmed in exoplanet atmospheres. An important example is chromium hydride (CrH), which is often used to probe atmospheric temperatures and classify brown dwarfs into spectral types. Recently, tentative evidence for CrH was reported in the low-resolution transmission spectrum of the hot Jupiter WASP-31b. Here, we present high spectral resolution observations of WASP-31b's transmission spectrum from GRACES/Gemini North and UVES/VLT. We detect CrH at 5.6$\sigma$ confidence, representing the first metal hydride detection in an exoplanet atmosphere at high spectral resolution. Our findings constitute a critical step in understanding the role of metal hydrides in exoplanet atmospheres., Comment: accepted to ApJL

Published
2023

207. Decalf: A Directed, Effectful Cost-Aware Logical Framework

Author

Grodin, Harrison, Niu, Yue, Sterling, Jonathan, and Harper, Robert

Subjects
Computer Science - Programming Languages
Abstract

We present ${\bf decalf}$, a ${\bf d}$irected, ${\bf e}$ffectful ${\bf c}$ost-${\bf a}$ware ${\bf l}$ogical ${\bf f}$ramework for studying quantitative aspects of functional programs with effects. Like ${\bf calf}$, the language is based on a formal phase distinction between the extension and the intension of a program, its pure behavior as distinct from its cost measured by an effectful step-counting primitive. The type theory ensures that the behavior is unaffected by the cost accounting. Unlike ${\bf calf}$, the present language takes account of effects, such as probabilistic choice and mutable state; this extension requires a reformulation of ${\bf calf}$'s approach to cost accounting: rather than rely on a "separable" notion of cost, here a cost bound is simply another program. To make this formal, we equip every type with an intrinsic preorder, relaxing the precise cost accounting intrinsic to a program to a looser but nevertheless informative estimate. For example, the cost bound of a probabilistic program is itself a probabilistic program that specifies the distribution of costs. This approach serves as a streamlined alternative to the standard method of isolating a recurrence that bounds the cost in a manner that readily extends to higher-order, effectful programs. The development proceeds by first introducing the ${\bf decalf}$ type system, which is based on an intrinsic ordering among terms that restricts in the extensional phase to extensional equality, but in the intensional phase reflects an approximation of the cost of a program of interest. This formulation is then applied to a number of illustrative examples, including pure and effectful sorting algorithms, simple probabilistic programs, and higher-order functions. Finally, we justify ${\bf decalf}$ via a model in the topos of augmented simplicial sets.

Published
2023
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208. Tunable quantum emitters on large-scale foundry silicon photonics

Author

Larocque, Hugo, Buyukkaya, Mustafa Atabey, Errando-Herranz, Carlos, Harper, Samuel, Carolan, Jacques, Lee, Chang-Min, Richardson, Christopher J. K., Leake, Gerald L., Coleman, Daniel J., Fanto, Michael L., Waks, Edo, and Englund, Dirk

Subjects
Physics - Optics, Quantum Physics
Abstract

Controlling large-scale many-body quantum systems at the level of single photons and single atomic systems is a central goal in quantum information science and technology. Intensive research and development has propelled foundry-based silicon-on-insulator photonic integrated circuits to a leading platform for large-scale optical control with individual mode programmability. However, integrating atomic quantum systems with single-emitter tunability remains an open challenge. Here, we overcome this barrier through the hybrid integration of multiple InAs/InP microchiplets containing high-brightness infrared semiconductor quantum dot single photon emitters into advanced silicon-on-insulator photonic integrated circuits fabricated in a 300~mm foundry process. With this platform, we achieve single photon emission via resonance fluorescence and scalable emission wavelength tunability through an electrically controlled non-volatile memory. The combined control of photonic and quantum systems opens the door to programmable quantum information processors manufactured in leading semiconductor foundries., Comment: 9 pages, 4 figures

Published
2023

209. Compression and Reduced Representation Techniques for Patch-Based Relaxation

Author

Harper, Graham and Tuminaro, Ray

Subjects
Mathematics - Numerical Analysis
Abstract

Patch-based relaxation refers to a family of methods for solving linear systems which partitions the matrix into smaller pieces often corresponding to groups of adjacent degrees of freedom residing within patches of the computational domain. The two most common families of patch-based methods are block-Jacobi and Schwarz methods, where the former typically corresponds to non-overlapping domains and the later implies some overlap. We focus on cases where each patch consists of the degrees of freedom within a finite element method mesh cell. Patch methods often capture complex local physics much more effectively than simpler point-smoothers such as Jacobi; however, forming, inverting, and applying each patch can be prohibitively expensive in terms of both storage and computation time. To this end, we propose several approaches for performing analysis on these patches and constructing a reduced representation. The compression techniques rely on either matrix norm comparisons or unsupervised learning via a clustering approach. We illustrate how it is frequently possible to retain/factor less than 5% of all patches and still develop a method that converges with the same number of iterations or slightly more than when all patches are stored/factored., Comment: 16 pages, 5 figures

Published
2023

210. Needle guidance with Doppler-tracked polarization-sensitive optical coherence tomography

Author

Harper, Danielle J., Kim, Yongjoo, Gómez-Ramírez, Alejandra, and Vakoc, Benjamin J.

Subjects
Physics - Medical Physics, Physics - Optics
Abstract

We demonstrate that a simple, unscanned polarization-sensitive optical coherence tomography needle probe can be used to perform layer identification in biological tissues. Broadband light from a laser centered at 1310 nm was sent through a fiber that was embedded into a needle, and analysis of the polarization state of the returning light after interference coupled with Doppler-based tracking allowed the calculation of phase retardation and optic axis orientation at each needle location. Proof-of-concept phase retardation mapping was shown in Atlantic salmon tissue, while axis orientation mapping was demonstrated in white shrimp tissue. The needle probe was then tested on the ex vivo porcine spine, where mock epidural procedures were performed. Our imaging results demonstrate that unscanned, Doppler-tracked polarization-sensitive optical coherence tomography imaging successfully identified the skin, subcutaneous tissue, and ligament layers, before successfully reaching the target of the epidural space. The addition of polarization-sensitive imaging into the bore of a needle probe therefore allows layer identification at deeper locations in the tissue., Comment: 11 pages, 4 figures. Supplemental videos can be found here: https://github.com/BenVakocLab/needle_videos

Published
2023

211. The geometry of the hot corona in MCG-05-23-16 constrained by X-ray polarimetry

Author

Tagliacozzo, D., Marinucci, A., Ursini, F., Matt, G., Bianchi, S., Baldini, L., Barnouin, T., Rodriguez, N. Cavero, De Rosa, A., Di Gesu, L., Dovciak, M., Harper, D., Ingram, A., Karas, V., Kim, D. E., Krawczynski, H., Madejski, G., Marin, F., Middei, R., Marshall, H. L., Muleri, F., Panagiotou, C., Petrucci, P. O., Podgorny, J., Poutanen, J., Puccetti, S., Soffitta, P., Tombesi, F., Veledina, A., Zhang, W., Agudo, I., Antonelli, L. A., Bachetti, M., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Chen, C. T., Ciprini, S., Costa, E., Del Monte, E., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J. A., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S. G., Kaaret, P., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marscher, A. P., Massaro, F., Mitsuishi, I., Mizuno, T., Negro, M., Ng, C. Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Rollins, M. Pesce, Pilia, M., Possenti, A., Ramsey, B. D., Rankin, J., Ratheesh, A., Roberts, O. J., Romani, R. W., Sgrò, C., Slane, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on the second observation of the radio-quiet active galactic nucleus (AGN) MCG-05-23-16 performed with the Imaging X-ray Polarimetry Explorer (IXPE). The observation started on 2022 November 6 for a net observing time of 640 ks, and was partly simultaneous with NuSTAR (86 ks). After combining these data with those obtained in the first IXPE pointing on May 2022 (simultaneous with XMM-Newton and NuSTAR) we find a 2-8 keV polarization degree $\Pi$ = 1.6 $\pm$ 0.7 (at 68 per cent confidence level), which corresponds to an upper limit $\Pi$ = 3.2 per cent (at 99 per cent confidence level). We then compare the polarization results with Monte Carlo simulations obtained with the MONK code, with which different coronal geometries have been explored (spherical lamppost, conical, slab and wedge). Furthermore, the allowed range of inclination angles is found for each geometry. If the best fit inclination value from a spectroscopic analysis is considered, a cone-shaped corona along the disc axis is disfavoured., Comment: 9 pages, 8 figures, 3 table. Submitted to MNRAS

Published
2023

212. Entangled Photon Correlations Allow a Continuous-Wave Laser Diode to Measure Single Photon, Time-Resolved Fluorescence

Author

Harper, Nathan, Hickam, Bryce P., He, Manni, and Cushing, Scott K.

Subjects
Quantum Physics, Physics - Optics
Abstract

Fluorescence lifetime experiments are a standard approach for measuring excited state dynamics and local environment effects. Here, we show that entangled photon pairs produced from a continuous-wave (CW) laser diode can replicate pulsed laser experiments without phase modulation. As a proof of principle, picosecond fluorescence lifetimes of indocyanine green are measured in multiple environments. The use of entangled photons has three unique advantages. First, low power CW laser diodes and entangled photon source design lead to straightforward on-chip integration for a direct path to distributable fluorescence lifetime measurements. Second, the entangled pair wavelength is easily tuned by temperature or electric field, allowing a single source to cover octave bandwidths. Third, femtosecond temporal resolutions can be reached without requiring major advances in source technology or external phase modulation. Entangled photons could therefore provide increased accessibility to time-resolved fluorescence while also opening new scientific avenues in photosensitive and inherently quantum systems.

Published
2023

213. QUIJOTE scientific results -- X. Spatial variations of Anomalous Microwave Emission along the Galactic plane

Author

Fernández-Torreiro, M., Rubiño-Martín, J. A., López-Caraballo, C. H., Génova-Santos, R. T., Peel, M. W., Guidi, F., Harper, S. E., Artal, E., Ashdown, M., Barreiro, R. B., Casas, F. J., de la Hoz, E., Herranz, D., Hoyland, R., Lasenby, A., Martínez-Gonzalez, E., Piccirillo, L., Poidevin, F., Rebolo, R., Ruiz-Granados, B., Tramonte, D., Vansyngel, F., Vielva, P., and Watson, R. A.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Anomalous Microwave Emission (AME) is an important emission component between 10 and 60 GHz that is not yet fully understood. It seems to be ubiquituous in our Galaxy and is observed at a broad range of angular scales. Here we use the new QUIJOTE-MFI wide survey data at 11, 13, 17 and 19 GHz to constrain the AME in the Galactic plane ($|b|<10^\circ$) on degree scales. We built the spectral energy distribution between 0.408 and 3000 GHz for each of the 5309 0.9$^\circ$ pixels in the Galactic plane, and fitted a parametric model by considering five emission components: synchrotron, free-free, AME, thermal dust and CMB anisotropies. We show that not including QUIJOTE-MFI data points leads to the underestimation (up to 50 %) of the AME signal in favour of free-free emission. The parameters describing these components are then intercompared, looking for relations that help to understand AME physical processes. We find median values for the AME width, $W_{\rm AME}$, and for its peak frequency, $\nu_{\rm AME}$, respectively of $0.560^{+0.059}_{-0.050}$ and $20.7^{+2.0}_{-1.9}$ GHz, slightly in tension with current theoretical models. We find spatial variations throughout the Galactic plane for $\nu_{\rm AME}$, but only with reduced statistical significance. We report correlations of AME parameters with certain ISM properties, such as that between the AME emissivity (which shows variations with the Galactic longitude) and the interstellar radiation field, and that between the AME peak frequency and dust temperature. Finally, we discuss the implications of our results on the possible molecules responsible for AME., Comment: 32 pages, 31 figures. Accepted for publication in MNRAS. Derived data products available at https://research.iac.es/proyecto/quijote

Published
2023
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214. Flight of the Bumblebee: the Early Excess Flux of Type Ia Supernova 2023bee revealed by $TESS$, $Swift$ and Young Supernova Experiment Observations

Author

Wang, Qinan, Rest, Armin, Dimitriadis, Georgios, Ridden-harper, Ryan, Siebert, Matthew R., Magee, Mark, Angus, Charlotte R., Auchettl, Katie, Davis, Kyle W., Foley, Ryan J., Fox, Ori D., Gomez, Sebastian, Jencson, Jacob E., Jones, David O., Kilpatrick, Charles D., Pierel, Justin D. R., Piro, Anthony L., Polin, Abigail, Politsch, Collin A., Rojas-bravo, César, Shahbandeh, Melissa, Villar, V. Ashley, Zenati, Yossef, Ashall, C., Chambers, Kenneth C., Coulter, David A., De Boer, Thomas, Dilullo, Nico, Gall, Christa, Gao, Hua, Hsiao, Eric Y., Huber, Mark E., Izzo, Luca, Khetan, Nandita, Lebaron, Natalie, Magnier, Eugene A., Mandel, Kaisey S., Mcgill, Peter, Miao, Hao-yu, Pan, Yen-chen, Stevens, Catherine P., Swift, Jonathan J., Taggart, Kirsty, and Yang, Grace

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present high-cadence ultraviolet through near-infrared observations of the Type Ia supernova (SN Ia) 2023bee in NGC~2708 ($D = 32 \pm 3$ Mpc), finding excess flux in the first days after explosion relative to the expected power-law rise from an expanding fireball. This deviation from typical behavior for SNe Ia is particularly obvious in our 10-minute cadence $TESS$ light curve and $Swift$ UV data. Compared to a few other normal SNe Ia with detected early excess flux, the excess flux in SN 2023bee is redder in the UV and less luminous. We present optical spectra of SN 2023bee, including two spectra during the period where the flux excess is dominant. At this time, the spectra are similar to those of other SNe Ia but with weaker Si II, C II and Ca II absorption lines, perhaps because the excess flux creates a stronger continuum. We compare the data to several theoretical models that have been proposed to explain the early flux excess in SNe Ia. Interaction with either a nearby companion star or close-in circumstellar material is expected to produce a faster evolution than seen in the data. Radioactive material in the outer layers of the ejecta, either from a double detonation explosion or simply an explosion with a $^{56}$Ni clump near the surface, can not fully reproduce the evolution either, likely due to the sensitivity of early UV observable to the treatment of the outer part of ejecta in simulation. We conclude that no current model can adequately explain the full set of observations. We find that a relatively large fraction of nearby, bright SNe Ia with high-cadence observations have some amount of excess flux within a few days of explosion. Considering potential asymmetric emission, the physical cause of this excess flux may be ubiquitous in normal SNe Ia., Comment: 21 pages, 12 figures. Accepted by the astrophysical journal

Published
2023

215. Improving Retention Factors and Student Success Online Utilizing the Community of Inquiry Framework's Instructor Presence Model

Author

Rosser-Majors, Michelle L., Rebeor, Sandra, McMahon, Christine, Wilson, Andrea, Stubbs, Stephanie L., Harper, Yolanda, and Sliwinski, Laura

Abstract

Considerable research on effective instruction in the virtual classroom exists. Yet very little is known about the extent to which instructor presence (IP) based on the Community of Inquiry model (CoI), are directly related to retention and student success. CoI includes three components of IP: teaching (TP), cognitive (CP), and social (SP). These IP engagement strategies have been suggested to improve outcomes if effectively applied in the virtual classroom. Attrition rates, retention, engagement, and student and instructor success rates are critical aspects of an effective virtual classroom and identifying practices that support these efforts is essential. This study suggests that CoI engagement strategies, when applied by instructors to the online classroom effectively, can improve factors associated with retention and success. To prepare instructors, we designed and utilized a series of seven self-paced interactive modules. With the training, the educators were able to engage with students more effectively by integrating best practices associated with IP. Course dropout rates and student success rates both significantly improved (p = 0.05; p < 0.001 respectively) after these engagement strategies were more efficaciously integrated into the classroom by the trained instructors.

Published
2022

216. The swimming habits of women who cold water swim

Author

Megan Pound, Heather Massey, Sasha Roseneil, Ruth Williamson, Mark Harper, Mike Tipton, Jill Shawe, Malika Felton, and Joyce Harper

Subjects
Medicine
Abstract

Background: Cold water swimming is growing in popularity, especially among women. We have previously reported that women felt that cold water swimming helps with their menstrual and menopause symptoms. But little is known about the habits of women who cold water swim. Objectives: To determine the habits of women who cold water swim. Design: This was a mixed-methods study. Methods: An online survey asked women who cold water swim about their experience of swimming and how this affected their menstrual and menopause symptoms. The survey was advertised for 2 months on social media, with a focus on advertising in cold water swimming Facebook groups. In this article, only the questions on the women’s swimming habits were analyzed. Results: The analysis of 1114 women, mainly from the United Kingdom, revealed that most had been swimming for 1–5 years (79.5%). Most swim in the sea (64.4%), and only 15.5% swim alone. The majority (89.0%) swim all year around, swimming for mainly 30–60 min in the summer and 5–15 min in the winter. The women mostly swim wearing swimming costumes (skins) throughout the year. The majority of the free-text responses showed women found mental and physical benefits from cold water swimming. Conclusion: It was not surprising to learn that women swim for longer in the summer than the winter, but hearing how they feel cold water swimming helps their physical and mental health is important. With the limitations on access and safety of many wild swimming sites in the United Kingdom, it is time to ensure that cold water swimming is safer and more supported.

Published
2024
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217. ASO Visual Abstract: Development of a Novel Protocol for Germline Testing in Pancreatic Cancer

Author

McDonald, Hannah G., Kennedy, Andrew, Solomon, Angelica L., Williams, Chelsey M., Reagan, Anna M., Cassim, Emily, Harper, Megan, Burke, Erin, Armstrong, Terra, Gosky, Michael, Cavnar, Michael, Pandalai, Prakash K., Barry-Hundeyin, Mautin, Patel, Reema, Nutalapati, Snigdha, Moss, Jessica, Hull, Pamela C., Kolesar, Jill, Pickarski, Justine C., and Kim, Joseph

Published
2024
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219. Oxylipin concentration shift in exhaled breath condensate (EBC) of SARS-CoV-2 infected patients

Author

Borras, Eva, McCartney, Mitchell M, Rojas, Dante E, Hicks, Tristan L, Tran, Nam K, Tham, Tina, Juarez, Maya M, Franzi, Lisa, Harper, Richart W, Davis, Cristina E, and Kenyon, Nicholas J

Subjects
Engineering, Biomedical Engineering, Lung, Infectious Diseases, Coronaviruses, Emerging Infectious Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, 4.1 Discovery and preclinical testing of markers and technologies, Infection, Good Health and Well Being, Humans, Oxylipins, COVID-19, SARS-CoV-2, Breath Tests, Metabolomics, Biomarkers, exhaled breath condensate, COVID 19, metabolomics, breath analysis, LC-qTOF, Biomedical engineering
Abstract

Infection of airway epithelial cells with severe acute respiratory coronavirus 2 (SARS-CoV-2) can lead to severe respiratory tract damage and lung injury with hypoxia. It is challenging to sample the lower airways non-invasively and the capability to identify a highly representative specimen that can be collected in a non-invasive way would provide opportunities to investigate metabolomic consequences of COVID-19 disease. In the present study, we performed a targeted metabolomic approach using liquid chromatography coupled with high resolution chromatography (LC-MS) on exhaled breath condensate (EBC) collected from hospitalized COVID-19 patients (COVID+) and negative controls, both non-hospitalized and hospitalized for other reasons (COVID-). We were able to noninvasively identify and quantify inflammatory oxylipin shifts and dysregulation that may ultimately be used to monitor COVID-19 disease progression or severity and response to therapy. We also expected EBC-based biochemical oxylipin changes associated with COVID-19 host response to infection. The results indicated ten targeted oxylipins showing significative differences between SAR-CoV-2 infected EBC samples and negative control subjects. These compounds were prostaglandins A2 and D2, LXA4, 5-HETE, 12-HETE, 15-HETE, 5-HEPE, 9-HODE, 13-oxoODE and 19(20)-EpDPA, which are associated with specific pathways (i.e. P450, COX, 15-LOX) related to inflammatory and oxidative stress processes. Moreover, all these compounds were up-regulated by COVID+, meaning their concentrations were higher in subjects with SAR-CoV-2 infection. Given that many COVID-19 symptoms are inflammatory in nature, this is interesting insight into the pathophysiology of the disease. Breath monitoring of these and other EBC metabolites presents an interesting opportunity to monitor key indicators of disease progression and severity.

Published
2023

220. Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial.

Author

Goulding, Alison, Antoniewicz, Leah, Leach, Justin, Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna, Bell, Joseph, Edwards, Rodney, Gibson, Kelly, Haas, David, Plante, Lauren, Metz, Torri, Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George, Hoppe, Kara, Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle, Simhan, Hyagriv, Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, Reddy, Uma, Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary, Skupski, Daniel, El-Sayed, Yasser, Ogunyemi, Dotun, Harper, Lorie, Ambalavanan, Namasivayam, Oparil, Suzanne, Szychowski, Jeff, and Tita, Alan

Subjects
blood pressure, breastfeeding, cardiovascular health, chronic hypertension, lactation, postpartum, pregnancy, Pregnancy, Female, Humans, Breast Feeding, Antihypertensive Agents, Hypertension, Blood Pressure, Postpartum Period
Abstract

BACKGROUND: Increased duration of breastfeeding improves maternal cardiovascular health and may be especially beneficial in high-risk populations, such as those with chronic hypertension. Others have shown that individuals with hypertension are less likely to breastfeed, and there has been limited research aimed at supporting breastfeeding goals in this population. The impact of perinatal blood pressure control on breastfeeding outcomes among people with chronic hypertension is unknown. OBJECTIVE: This study aimed to evaluate whether breastfeeding initiation and short-term duration assessed at the postpartum clinic visit differed according to perinatal blood pressure treatment strategy (targeting blood pressure

Published
2023

221. Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway.

Author

Harper, Christine, Zhang, Wenyao, Lee, Junsung, Shin, Jung-Ho, Keller, Megan, van Wijngaarden, Ellen, Chou, Emily, Wang, Zhaohong, Dörr, Tobias, Chen, Peng, and Hernandez, Christopher

Subjects
Cell Membrane, Cell Wall, Homeostasis, Anti-Bacterial Agents, Gene Expression
Abstract

Mechanosensitive mechanisms are often used to sense damage to tissue structure, stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well recognized in eukaryotic systems, it is not known whether such a process occurs in bacteria. In Vibrio cholerae, antibiotic-induced damage to the load-bearing cell wall promotes increased signaling by the two-component system VxrAB, which stimulates cell wall synthesis. Here we show that changes in mechanical stress within the cell envelope are sufficient to stimulate VxrAB signaling in the absence of antibiotics. We applied mechanical forces to individual bacteria using three distinct loading modalities: extrusion loading within a microfluidic device, direct compression and hydrostatic pressure. In all cases, VxrAB signaling, as indicated by a fluorescent protein reporter, was increased in cells submitted to greater magnitudes of mechanical loading, hence diverse forms of mechanical stimuli activate VxrAB signaling. Reduction in cell envelope stiffness following removal of the endopeptidase ShyA led to large increases in cell envelope deformation and substantially increased VxrAB response, further supporting the responsiveness of VxrAB. Our findings demonstrate a mechanosensitive gene regulatory system in bacteria and suggest that mechanical signals may contribute to the regulation of cell wall homeostasis.

Published
2023

222. Dynamics of Rayleigh Fission Processes in ∼100 nm Charged Aqueous Nanodrops.

Author

Hanozin, Emeline, Harper, Conner, McPartlan, Matthew, and Williams, Evan

Abstract

Fission of micron-size charged droplets has been observed using optical methods, but little is known about fission dynamics and breakup of smaller nanosize droplets that are important in a variety of natural and industrial processes. Here, spontaneous fission of individual aqueous nanodrops formed by electrospray is investigated using charge detection mass spectrometry. Fission processes ranging from formation of just two progeny droplets in 2 ms to production of dozens of progeny droplets over 100+ ms are observed for nanodrops that are charged above the Rayleigh limit. These results indicate that Rayleigh fission is a continuum of processes that produce progeny droplets that vary widely in charge, mass, and number.

Published
2023

223. Work of Breathing During Proportional Assist Ventilation as a Predictor of Extubation Failure.

Author

Fazio, Sarina A, Lin, Gary, Cortés-Puch, Irene, Stocking, Jacqueline C, Tokeshi, Bradley, Kuhn, Brooks T, Adams, Jason Y, and Harper, Richart

Subjects
Humans, Work of Breathing, Ventilator Weaning, Respiration, Adult, Airway Extubation, Interactive Ventilatory Support, endotracheal tube, extubation, mechanical ventilation, noninvasive ventilation, rapid shallow breathing index, weaning, Lung, Clinical Research, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Respiratory System
Abstract

BackgroundDespite decades of research on predictors of extubation success, use of ventilatory support after extubation is common and 10-20% of patients require re-intubation. Proportional assist ventilation (PAV) mode automatically calculates estimated total work of breathing (total WOB). Here, we assessed the performance of total WOB to predict extubation failure in invasively ventilated subjects.MethodsThis prospective observational study was conducted in 6 adult ICUs at an academic medical center. We enrolled intubated subjects who successfully completed a spontaneous breathing trial, had a rapid shallow breathing index < 105 breaths/min/L, and were deemed ready for extubation by the primary team. Total WOB values were recorded at the end of a 30-min PAV trial. Extubation failure was defined as any respiratory support and/or re-intubation within 72 h of extubation. We compared total WOB scores between groups and performance of total WOB for predicting extubation failure with receiver operating characteristic curves.ResultsOf 61 subjects enrolled, 9.8% (n = 6) required re-intubation, and 50.8% (n = 31) required any respiratory support within 72 h of extubation. Median total WOB at 30 min on PAV was 0.9 J/L (interquartile range 0.7-1.3 J/L). Total WOB was significantly different between subjects who failed or were successfully extubated (median 1.1 J/L vs 0.7 J/L, P = .004). The area under the curve was 0.71 [95% CI 0.58-0.85] for predicting any requirement of respiratory support and 0.85 [95% CI 0.69-1.00] for predicting re-intubation alone within 72 h of extubation. Total WOB cutoff values maximizing sensitivity and specificity equally were 1.0 J/L for any respiratory support (positive predictive value [PPV] 70.0%, negative predictive value [NPV] 67.7%) and 1.3 J/L for re-intubation (PPV 26.3%, NPV 97.6%).ConclusionsThe discriminative performance of a PAV-derived total WOB value to predict extubation failure was good, indicating total WOB may represent an adjunctive tool for assessing extubation readiness. However, these results should be interpreted as preliminary, with specific thresholds of PAV-derived total WOB requiring further investigation in a large multi-center study.

Published
2023

224. A 40TH ANNIVERSARY LOVE STORY: ABOUT MY FAVORITE MAGAZINE

Author

Harper, Shaun

Subjects
Education, Higher -- Personal narratives, African American universities and colleges -- Personal narratives, Periodicals -- Personal narratives, Education, Ethnic, cultural, racial issues/studies, Indiana University
Abstract

It was love at first sight. I remember seeing copies of Black Issues in Higher Education in various administrators' offices at Albany State, the historically Black university where I was [...]

Published
2024

225. Pathology Residents' Perceptions and Attitudes Toward Breast Pathology: A National Survey

Author

Harper, Erika M., Henderson-Jackson, Evita, and Rosa, Marilin

Subjects
Health
Abstract

* Context.--Breast pathology (BP) is considered to be subject to interobserver variability among pathologists, emphasizing the need for adequate training. However, specifics of BP residency training have not been elucidated. Objective.--To assess the characteristics of BP residency training in the United States. Design.--A Qualtrics-managed online survey was emailed to program directors of all US pathology residency programs, requesting them to forward the survey link to their pathology residents. Results.--One hundred seventeen residents' survey responses were evaluable. Most responses (92; 79%) came from residents in university hospital-based programs. Thirty-five respondents (30%) had a dedicated BP rotation in their program. Most respondents believed that BP was an important part of training (96 of 100; 96%) and pathology practice (95 of 100; 95%). Seventy-one respondents believed that their BP training was adequate overall (71 of 100; 71%). Forty-one percent of respondents indicated that they would not like BP to be a significant part of their future practice. The main reasons given were that they had a different preferred area of interest, that they lacked interest in BP, or that breast cases were time-consuming to sign out. Conclusions.--Our results show that in the United States, most programs do not offer a dedicated BP rotation, but breast cases are signed out by subspecialized or experienced breast pathologists. In addition, most respondents believed that they received adequate training and would be competent to independently sign out BP in the future. Additional studies addressing new-in-practice pathologists' proficiency in BP will further help elucidate the quality of BP training in the United States., Breast pathology (BP) is widely considered one of the most complicated and time-consuming subspecialties of pathology, with a tendency for interobserver variability in the interpretation of many lesions. (1-3) In [...]

Published
2024
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239. Portable Acceleration of CMS Computing Workflows with Coprocessors as a Service

Author

Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Hussain, P. S., Jeitler, M., Krammer, N., Li, A., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Mechelen, P. Van, Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., Faham, H. El, Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Onsem, G. P. Van, Putte, S. Van, Vannerom, D., Clerbaux, B., Das, A. K., De Lentdecker, G., Favart, L., Gianneios, P., Hohov, D., Jaramillo, J., Khalilzadeh, A., Khan, F. A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Thomas, L., Bemden, M. Vanden, Velde, C. Vander, Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Amarilo, K. Mota, Rendón, C., Samalan, A., Skovpen, K., Bossche, N. Van Den, Linden, J. van der, Wezenbeek, L., Benecke, A., Bethani, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, Sa., Lemaitre, V., Lidrych, J., Mastrapasqua, P., Mondal, K., Tran, T. T., Wertz, S., Alves, G. A., Coelho, E., Hensel, C., De Oliveira, T. Menezes, Moraes, A., Teles, P. Rebello, Soeiro, M., Júnior, W. L. Aldá, Pereira, M. Alves Gallo, Filho, M. Barroso Ferreira, Malbouisson, H. Brandao, Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Souza, S. Fonseca, De Souza, R. Gomes, Martins, J., Herrera, C. Mora, Mundim, L., Nogima, H., Pinheiro, J. P., Santoro, A., Sznajder, A., Thiel, M., Pereira, A. Vilela, Bernardes, C. A., Calligaris, L., Tomei, T. R. Fernandez Perez, Gregores, E. M., Mercadante, P. G., Novaes, S. F., Orzari, B., Padula, Sandra S., Aleksandrov, A., Antchev, G., Hadjiiska, R., Iaydjiev, P., Misheva, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Petrov, A., Shumka, E., Keshri, S., Thakur, S., Cheng, T., Javaid, T., Yuan, L., Hu, Z., Liu, J., Yi, K., Chen, G. M., Chen, H. S., Chen, M., Iemmi, F., Jiang, C. H., Kapoor, A., Liao, H., Liu, Z.-A., Sharma, R., Song, J. N., Tao, J., Wang, C., Wang, J., Wang, Z., Zhang, H., Agapitos, A., Ban, Y., Levin, A., Li, C., Li, Q., Mao, Y., Qian, S. J., Sun, X., Wang, D., Yang, H., Zhang, L., Zhou, C., You, Z., Lu, N., Bauer, G., Gao, X., Leggat, D., Okawa, H., Lin, Z., Lu, C., Xiao, M., Avila, C., Trujillo, D. A. Barbosa, Cabrera, A., Florez, C., Fraga, J., Vega, J. A. Reyes, Guisao, J. Mejia, Ramirez, F., Rodriguez, M., Alvarez, J. D. Ruiz, Giljanovic, D., Godinovic, N., Lelas, D., Sculac, A., Kovac, M., Sculac, T., Bargassa, P., Brigljevic, V., Chitroda, B. K., Ferencek, D., Mishra, S., Starodumov, A., Susa, T., Attikis, A., Christoforou, K., Konstantinou, S., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Saka, H., Stepennov, A., Finger, M., Finger, Jr., M., Kveton, A., Ayala, E., Jarrin, E. Carrera, Abdelalim, A. A., Salama, E., Mahmoud, M. A., Mohammed, Y., Ehataht, K., Kadastik, M., Lange, T., Nandan, S., Nielsen, C., Pata, J., Raidal, M., Tani, L., Veelken, C., Kirschenmann, H., Osterberg, K., Voutilainen, M., Bharthuar, S., Brücken, E., Garcia, F., Kallonen, K. T. S., Kinnunen, R., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Martikainen, L., Myllymäki, M., Rantanen, M.m., Siikonen, H., Tuominen, E., Tuominiemi, J., Luukka, P., Petrow, H., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Gras, P., de Monchenault, G. Hamel, Lohezic, V., Malcles, J., Rander, J., Rosowsky, A., Sahin, M. Ö., Savoy-Navarro, A., Simkina, P., Titov, M., Tornago, M., Barrera, C. Baldenegro, Beaudette, F., Perraguin, A. Buchot, Busson, P., Cappati, A., Charlot, C., Chiusi, M., Damas, F., Davignon, O., De Wit, A., Alves, B. A. Fontana Santos, Ghosh, S., Gilbert, A., de Cassagnac, R. Granier, Hakimi, A., Harikrishnan, B., Kalipoliti, L., Liu, G., Motta, J., Nguyen, M., Ochando, C., Portales, L., Salerno, R., Sauvan, J. B., Sirois, Y., Tarabini, A., Vernazza, E., Zabi, A., Zghiche, A., Agram, J.-L., Andrea, J., Apparu, D., Bloch, D., Brom, J.-M., Chabert, E. C., Collard, C., Falke, S., Goerlach, U., Grimault, C., Haeberle, R., Bihan, A.-C. Le, Meena, M., Saha, G., Sessini, M. A., Hove, P. Van, Beauceron, S., Blancon, B., Boudoul, G., Chanon, N., Choi, J., Contardo, D., Depasse, P., Dozen, C., Mamouni, H. El, Fay, J., Gascon, S., Gouzevitch, M., Greenberg, C., Grenier, G., Ille, B., Laktineh, I. B., Lethuillier, M., Mirabito, L., Perries, S., Purohit, A., Donckt, M. Vander, Verdier, P., Xiao, J., Bagaturia, I., Lomidze, I., Tsamalaidze, Z., Botta, V., Feld, L., Klein, K., Lipinski, M., Meuser, D., Pauls, A., Röwert, N., Teroerde, M., Diekmann, S., Dodonova, A., Eich, N., Eliseev, D., Engelke, F., Erdmann, J., Erdmann, M., Fackeldey, P., Fischer, B., Hebbeker, T., Hoepfner, K., Ivone, F., Jung, A., Lee, M.y., Mausolf, F., Merschmeyer, M., Meyer, A., Mukherjee, S., Noll, D., Nowotny, F., Pozdnyakov, A., Rath, Y., Redjeb, W., Rehm, F., Reithler, H., Sarkar, U., Sarkisovi, V., Schmidt, A., Sharma, A., Spah, J. L., Stein, A., Da Silva De Araujo, F. Torres, Vigilante, L., Wiedenbeck, S., Zaleski, S., Dziwok, C., Flügge, G., Ahmad, W. Haj, Kress, T., Nowack, A., Pooth, O., Stahl, A., Ziemons, T., Zotz, A., Petersen, H. Aarup, Martin, M. Aldaya, Alimena, J., Amoroso, S., An, Y., Baxter, S., Bayatmakou, M., Gonzalez, H. Becerril, Behnke, O., Belvedere, A., Bhattacharya, S., Blekman, F., Borras, K., Campbell, A., Cardini, A., Cheng, C., Colombina, F., Rodríguez, S. Consuegra, Silva, G. Correia, De Silva, M., Eckerlin, G., Eckstein, D., Banos, L. I. Estevez, Filatov, O., Gallo, E., Geiser, A., Giraldi, A., Guglielmi, V., Guthoff, M., Hinzmann, A., Jafari, A., Jeppe, L., Jomhari, N. Z., Kaech, B., Kasemann, M., Kleinwort, C., Kogler, R., Komm, M., Krücker, D., Lange, W., Pernia, D. Leyva, Lipka, K., Lohmann, W., Mankel, R., Melzer-Pellmann, I.-A., Morentin, M. Mendizabal, Meyer, A. B., Milella, G., Mussgiller, A., Nair, L. P., Nürnberg, A., Otarid, Y., Park, J., Adán, D. Pérez, Ranken, E., Raspereza, A., Lopes, B. Ribeiro, Rübenach, J., Saggio, A., Scham, M., Schnake, S., Schütze, P., Schwanenberger, C., Selivanova, D., Sharko, K., Shchedrolosiev, M., Ricardo, R. E. Sosa, Stafford, D., Vazzoler, F., Barroso, A. Ventura, Walsh, R., Wang, Q., Wen, Y., Wichmann, K., Wiens, L., Wissing, C., Yang, Y., Santos, A. Zimermmane Castro, Albrecht, A., Albrecht, S., Antonello, M., Bein, S., Benato, L., Bollweg, S., Bonanomi, M., Connor, P., Eich, M., Morabit, K. El, Fischer, Y., Garbers, C., Garutti, E., Grohsjean, A., Haller, J., Jabusch, H. R., Kasieczka, G., Keicher, P., Klanner, R., Korcari, W., Kramer, T., Kutzner, V., Labe, F., Lange, J., Lobanov, A., Matthies, C., Mehta, A., Moureaux, L., Mrowietz, M., Nigamova, A., Nissan, Y., Paasch, A., Rodriguez, K. J. Pena, Quadfasel, T., Raciti, B., Rieger, M., Savoiu, D., Schindler, J., Schleper, P., Schröder, M., Schwandt, J., Sommerhalder, M., Stadie, H., Steinbrück, G., Tews, A., Wolf, M., Brommer, S., Burkart, M., Butz, E., Chwalek, T., Dierlamm, A., Droll, A., Faltermann, N., Giffels, M., Gottmann, A., Hartmann, F., Hofsaess, R., Horzela, M., Husemann, U., Kieseler, J., Klute, M., Koppenhöfer, R., Lawhorn, J. M., Link, M., Lintuluoto, A., Maier, S., Mitra, S., Mormile, M., Müller, Th., Neukum, M., Oh, M., Presilla, M., Quast, G., Rabbertz, K., Regnery, B., Shadskiy, N., Shvetsov, I., Simonis, H. J., Toms, M., Trevisani, N., Cube, R. F. Von, Wassmer, M., Wieland, S., Wittig, F., Wolf, R., Zuo, X., Anagnostou, G., Daskalakis, G., Kyriakis, A., Papadopoulos, A., Stakia, A., Kontaxakis, P., Melachroinos, G., Panagiotou, A., Papavergou, I., Paraskevas, I., Saoulidou, N., Theofilatos, K., Tziaferi, E., Vellidis, K., Zisopoulos, I., Bakas, G., Chatzistavrou, T., Karapostoli, G., Kousouris, K., Papakrivopoulos, I., Siamarkou, E., Tsipolitis, G., Zacharopoulou, A., Adamidis, K., Bestintzanos, I., Evangelou, I., Foudas, C., Kamtsikis, C., Katsoulis, P., Kokkas, P., Kioseoglou, P. G. Kosmoglou, Manthos, N., Papadopoulos, I., Strologas, J., Bartók, M., Hajdu, C., Horvath, D., Márton, K., Sikler, F., Veszpremi, V., Csanád, M., Farkas, K., Gadallah, M. M. A., Kadlecsik, Á., Major, P., Mandal, K., Pásztor, G., Rádl, A. J., Veres, G. I., Raics, P., Ujvari, B., Zilizi, G., Bencze, G., Czellar, S., Molnar, J., Szillasi, Z., Csorgo, T., Nemes, F., Novak, T., Babbar, J., Bansal, S., Beri, S. B., Bhatnagar, V., Chaudhary, G., Chauhan, S., Dhingra, N., Kaur, A., Kaur, A., Kaur, H., Kaur, M., Kumar, S., Sandeep, K., Sheokand, T., Singh, J. B., Singla, A., Ahmed, A., Bhardwaj, A., Chhetri, A., Choudhary, B. C., Kumar, A., Kumar, A., Naimuddin, M., Ranjan, K., Saumya, S., Baradia, S., Barman, S., Bhattacharya, S., Dutta, S., Dutta, S., Sarkar, S., Ameen, M. M., Behera, P. K., Behera, S. C., Chatterjee, S., Jana, P., Kalbhor, P., Komaragiri, J. R., Kumar, D., Pujahari, P. R., Saha, N. R., Sharma, A., Sikdar, A. K., Verma, S., Dugad, S., Kumar, M., Mohanty, G. B., Suryadevara, P., Bala, A., Banerjee, S., Chatterjee, R. M., Dewanjee, R. K., Guchait, M., Jain, Sh., Jaiswal, A., Karmakar, S., Kumar, S., Majumder, G., Mazumdar, K., Parolia, S., Thachayath, A., Bahinipati, S., Kar, C., Maity, D., Mal, P., Mishra, T., Bindhu, V. K. Muraleedharan Nair, Naskar, K., Nayak, A., Sadangi, P., Saha, P., Swain, S. K., Varghese, S., Vats, D., Acharya, S., Alpana, A., Dube, S., Gomber, B., Kansal, B., Laha, A., Sahu, B., Sharma, S., Vaish, K. Y., Bakhshiansohi, H., Khazaie, E., Zeinali, M., Chenarani, S., Etesami, S. M., Khakzad, M., Najafabadi, M. Mohammadi, Grunewald, M., Abbrescia, M., Aly, R., Colaleo, A., Creanza, D., D’Anzi, B., De Filippis, N., De Palma, M., Florio, A. Di, Elmetenawee, W., Fiore, L., Iaselli, G., Louka, M., Maggi, G., Maggi, M., Margjeka, I., Mastrapasqua, V., My, S., Nuzzo, S., Pellecchia, A., Pompili, A., Pugliese, G., Radogna, R., Ramirez-Sanchez, G., Ramos, D., Ranieri, A., Silvestris, L., Simone, F. 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E., Dini, P., Gennai, S., Gerosa, R., Ghezzi, A., Govoni, P., Guzzi, L., Lucchini, M. T., Malberti, M., Malvezzi, S., Massironi, A., Menasce, D., Moroni, L., Paganoni, M., Pedrini, D., Pinolini, B. S., Ragazzi, S., de Fatis, T. Tabarelli, Zuolo, D., Buontempo, S., Cagnotta, A., Carnevali, F., Cavallo, N., Fabozzi, F., Iorio, A. O. M., Lista, L., Paolucci, P., Rossi, B., Sciacca, C., Ardino, R., Azzi, P., Bacchetta, N., Bisello, D., Bortignon, P., Bragagnolo, A., Checchia, P., Dorigo, T., Gasparini, U., Lusiani, E., Margoni, M., Marini, F., Meneguzzo, A. T., Migliorini, M., Passaseo, M., Pazzini, J., Ronchese, P., Rossin, R., Sgaravatto, M., Simonetto, F., Strong, G., Tosi, M., Triossi, A., Ventura, S., Yarar, H., Zanetti, M., Zotto, P., Zucchetta, A., Zumerle, G., Zeid, S. Abu, Aimè, C., Braghieri, A., Calzaferri, S., Fiorina, D., Montagna, P., Re, V., Riccardi, C., Salvini, P., Vai, I., Vitulo, P., Ajmal, S., Bilei, G. M., Ciangottini, D., Fanò, L., Magherini, M., Mantovani, G., Mariani, V., Menichelli, M., Moscatelli, F., Rossi, A., Santocchia, A., Spiga, D., Tedeschi, T., Asenov, P., Azzurri, P., Bagliesi, G., Bhattacharya, R., Bianchini, L., Boccali, T., Bossini, E., Bruschini, D., Castaldi, R., Ciocci, M. A., Cipriani, M., D’Amante, V., Dell’Orso, R., Donato, S., Giassi, A., Ligabue, F., Figueiredo, D. Matos, Messineo, A., Musich, M., Palla, F., Rizzi, A., Rolandi, G., Chowdhury, S. Roy, Sarkar, T., Scribano, A., Spagnolo, P., Tenchini, R., Tonelli, G., Turini, N., Venturi, A., Verdini, P. G., Barria, P., Basile, C., Campana, M., Cavallari, F., Mendez, L. Cunqueiro, Re, D. Del, Marco, E. 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F., Vetens, W., Warden, A., Afanasiev, S., Andreev, V., Andreev, Yu., Aushev, T., Azarkin, M., Babaev, A., Belyaev, A., Blinov, V., Boos, E., Borshch, V., Budkouski, D., Chadeeva, M., Chekhovsky, V., Chistov, R., Demiyanov, A., Dermenev, A., Dimova, T., Druzhkin, D., Dubinin, M., Dudko, L., Ershov, A., Gavrilov, G., Gavrilov, V., Gninenko, S., Golovtcov, V., Golubev, N., Golutvin, I., Gorbunov, I., Gribushin, A., Ivanov, Y., Kachanov, V., Karjavine, V., Karneyeu, A., Kim, V., Kirakosyan, M., Kirpichnikov, D., Kirsanov, M., Klyukhin, V., Kodolova, O., Korenkov, V., Kozyrev, A., Krasnikov, N., Lanev, A., Levchenko, P., Lychkovskaya, N., Makarenko, V., Malakhov, A., Matveev, V., Murzin, V., Nikitenko, A., Obraztsov, S., Oreshkin, V., Palichik, V., Perelygin, V., Petrushanko, S., Polikarpov, S., Popov, V., Radchenko, O., Savina, M., Savrin, V., Shalaev, V., Shmatov, S., Shulha, S., Skovpen, Y., Slabospitskii, S., Smirnov, V., Snigirev, A., Sosnov, D., Sulimov, V., Tcherniaev, E., Terkulov, A., Teryaev, O., Tlisova, I., Toropin, A., Uvarov, L., Uzunian, A., Vorobyev, A., Voytishin, N., Yuldashev, B. S., Zarubin, A., Zhizhin, I., and Zhokin, A.

Published
2024
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242. Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY

Author

Andrews, Colm D., Mathur, Rohini, Massey, Jon, Park, Robin, Curtis, Helen J., Hopcroft, Lisa, Mehrkar, Amir, Bacon, Seb, Hickman, George, Smith, Rebecca, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Dillingham, Iain, Maude, Steven, O’Dwyer, Thomas, Butler-Cole, Ben F. C., Bridges, Lucy, Bates, Chris, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie A., Walker, Alex J., and Hulme, William J.

Published
2024
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245. Prevalence and risk of burnout among HIV service providers in South Africa and Zambia: findings from the HPTN 071 (PopART) trial

Author

Steinhaus, Mara C., Nicholson, Tamaryn J., Pliakas, Triantafyllos, Harper, Abigail, Lilleston, Pamela, Mainga, Tila, Milimo, Deborah, Jennings, Karen, Grobbelaar, Nelis, Louis, Francoise, Liebenberg, Handri, Hayes, Richard J., Fidler, Sarah, Ayles, Helen, Bock, Peter, Hoddinott, Graeme, Hargreaves, James R., Bond, Virginia, and Stangl, Anne L.

Published
2024
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246. Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England

Author

Pessoa-Amorim, Guilherme, Goldacre, Raphael, Crichton, Charles, Stevens, Will, Nunn, Michelle, King, Andy, Murray, Dave, Welsh, Richard, Pinches, Heather, Rees, Andrew, Morris, Eva J. A., Landray, Martin J., Haynes, Richard, Horby, Peter, Wallendszus, Karl, Peto, Leon, Campbell, Mark, Harper, Charlie, and Mafham, Marion

Published
2024
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249. An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs

Author

Chapple, Richard H., Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I. M., Kim, Yuna, Patel, Anand G., LaFlamme, Christy W., Pan, Min, Wright, William C., Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C., Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D., Confer, Thomas, Akers, Walter J., Dyer, Michael A., Sheppard, Heather, Easton, John, and Geeleher, Paul

Published
2024
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