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471 results on '"Haddadin, A. J."'

237. Retraction Note to: Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells.

Author

Gali-Muhtasib, Hala U., Diab-Assaf, Mona, and Haddadin, Makhluf J.

Subjects
QUINOXALINES, COLON cancer, APOPTOSIS
Abstract

The authors have retracted this article because of overlap in images within the publication and with another previously published article. It was brought to our attention that there are inconsistencies in Figs. 3, 5 and 6. The left middle panel in Fig. 3, labeled "Ctrl", is the same as the left panel in Fig. 6, labeled "PD98059", except that the latter is flipped upside down and right-left. In Fig. 5, the gel in the middle left panel labeled TGF-β2 has been cropped in two different ways and used in Figs. 2 and 3 of Harakeh et al. This has been investigated by the Internal Research Integrity panel of the American University of Beirut who recommended retraction of the article as the original data are not available. *All authors agree to this retraction. [ABSTRACT FROM AUTHOR]

Published
2018
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250. Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-alkylation/tandem cyclization.

Author

Nguyen, Huy H., Fettinger, James C., Haddadin, Makhluf J., and Kurth, Mark J.

Subjects
*ISOQUINOLINE, *ALKYLATION, *RING formation (Chemistry), *TRANSITION metal compounds synthesis, *ANNULATION, *CARBAMATES, *PHOTOLUMINESCENCE
Abstract

A transition metal-free, one-pot protocol has been developed for the synthesis of 11 H -indolo[3,2- c ]isoquinolin-5-amines via the atom economical annulation of ethyl (2-cyano-phenyl)carbamates and 2-cyanobenzyl bromides. This method proceeds via sequential N-alkylation and base-promoted cyclization. Optimization data, substrate scope, mechanistic insights, and photoluminescence properties are discussed. [ABSTRACT FROM AUTHOR]

Published
2015
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