5,568 results on '"HEMLATA"'
Search Results
202. Enhancement of Germination on Abrus Precatorius L. Seeds by Specific Pre-sowing Treatments
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Vinay PRAKASH, Atul NAINWAL, Awaneendra Singh RAWAT, Jai Singh CHAUHAN, and Hemlata BISHT
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Abrus precatorius ,pre-sowing ,water imbibition ,scarification ,mechanical scarifier ,germination ,Fine Arts ,Arts in general ,NX1-820 - Abstract
Herbal medicines are in great demand for preliminary health care due to their wide medicinal value, with no side effects. Since many species are used in the system of traditional medicine, scientists have great opportunities to develop appropriate packages of practices for their multiplication and conservation. Abrus precatorius is the native plant of India and used in many ways in the Indian Ayurvedic system of medicine. This seeds of the species is dormant due to hard seed coat. So the aim of the study is to remove seed dormancy and enhance germination capacity within a short period. To overcome the problem of dormancy, seeds were scarified by seed scarifier and sand paper and also treated with acid (H2SO4) and hot water just before sowing. 60-95% germination was achieved under different treatment conditions while the seeds without any treatment fail to germinate. The highest (95%) germination was observed just 12 days after sowing in seeds treated with concentrated H2SO4 for 120 minutes. 70-75% germination was achieved when the seeds were treated with acid for 105 and 135 minutes. Seeds treated with con. H2SO4 for 150, 90 and 60 minutes and also scarified by sand paper showed similar results with 60-65% germination. The seeds scarified by a mechanical scarifier and treated with hot water did not show more than 32.5% germination.
- Published
- 2013
203. Solitary Peutz Jeghers Polyp Causing Jejunal-Jejunal Intussusception in 6-Year-Old Female Child
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Khushboo Birla, Sunita Sanjay Dantkale, Hemlata Kamra, Pankaj W. Sakinlawar, and Swapnil D. Chandekar
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peutz-jeghers syndrome ,solitary peutz-jeghers polyp ,hamartomatous ,gene ,stk-11 ,intussusception ,Microbiology ,QR1-502 ,Chemistry ,QD1-999 - Abstract
Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant syndrome characterised by the familial occurrence of gastrointestinal hamartomatous polyps in association with mucocutaneous hyperpigmentation. We here report a case of 6 yr old female child presented with colicky abdominal pain, nausea and vomiting. The patient underwent laparotomy due to small bowel intussusception secondary to a jejunal polyp. Histological examination showed the characteristic features of Peutz-Jeghers Polyp (PJP), but no other features of (PJS) as laid down by WHO were seen. Solitary PJP is an extremely rare condition, with an estimated incidence of 1:1,20,000 and all previously reported patients were older than this patient.
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- 2013
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204. Quantitative Enhancement of Active Content and Biomass of Two Aconitum Species Through Suitable Cultivation Technology
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Raman BAHUGUNA, Vinay PRAKASH, and Hemlata BISHT
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Aconitum balfourii ,Aconitum heterophyllum ,greenhouse ,natural condition ,active content ,pseudoaconitine ,aconitine ,atisine ,Fine Arts ,Arts in general ,NX1-820 - Abstract
High altitude medicinal plants are facing problem due to their unsustainable utilization. So, the cultivation of these plants with appropriate technology may fulfill the demand of pharmaceutical industry and may also promote the conservation at their natural habitat. Highly important two species of Aconitum were studied for the enhancement of net profit by applying protected farming system. Both the experimental species were grown under natural and greenhouse conditions. Very positive results were obtained in plants of both Aconitum species grown under greenhouse as compared to natural conditions. Enhancement in yield was 12 and 9 times high in Aconitum heterophyllum Wall. ex Royle and Aconitum balfourii Stapf. respectively grown under greenhouse as compared to natural condition. Pseudoaconitine and aconitine were also observed high in greenhouse grown (0.51% and 0.42% respectively) than naturally grown plants (0.49% and 0.40% respectively). The quantity of atisine and aconitine was also found high (0.35% & 0.27% respectively) in greenhouse than naturally grown plants (0.19% & 0.16% respectively). It was noticed that plant height, leaf number, and average length of tubers were high in plants grown inside greenhouse in contrast to natural habitat. Almost five and two folds more tubers were found in A. balfourii and A. heterophyllum respectively in plants grown under greenhouse in comparison to natural conditions.
- Published
- 2013
205. DISEASES OF EGGPLANT (SOLANUMMELONGENA) AND THEIR MANAGEMENT
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Pant, Hemlata, primary, Maurya, Amit Kumar, additional, John, Vinny, additional, and Singh, Manoj Kumar, additional
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- 2024
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206. RENEWABLE ENERGY SOURCES: A SUSTAINABLE PATH TO A GREENER FUTURE
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Verma, Jyoti, primary, Pant, Hemlata, additional, Padhi, Deepanjana, additional, Yadav, Anuradha, additional, Gupta, Nidhi, additional, and Sharma, Aditya, additional
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- 2024
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207. Sensitivity of Stock Pricing to the Optimistic and Pessimistic Sentiment of Social Media: A Shreds of Evidence from Nifty Indices
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Gaikwad, Hemlata Vivek, primary, Patil, Krishnaji Sarjerao, additional, Karanjkar, Shrikant Sharad, additional, and Patil, Digvijay Satish, additional
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- 2024
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208. Study Of Menstrual Pattern and Menstrual Hygiene Practices Among Adolescent Girls
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Hemlata G Rokade and Anjali P Kumavat
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Menstrual Hygiene ,Menarche ,Adolescent ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Menstrual hygiene and management will directly contribute to MDG-2 and MDG-3. This study was conducted to know the awareness about menstruation before menarche and the source of information; to compare menstrual pattern and menstrual hygiene among adolescent girls from slum and non-slum area and also to find some socio-demographic determinants of menstrual hygiene. Methods: A cross sectional study was conducted among 324 late adolescent girls, 200 from slum and 124 from non-slum. House to house survey was done. Results: Awareness of menstruation before menarche was seen in 56.48% girls. Friends [38.8%] and mothers [38.25%] were the main informant. The difference in mean age of menarche [12.85±1.13 in slum and 13.12±1.15 in non-slum] and regularity of cycles [126(63%) in slum and 102(82.26%) in non-slum] was statistically significant, p
- Published
- 2016
209. Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans.
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Miki Fujioka, Hemlata Mistry, Paul Schedl, and James B Jaynes
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Genetics ,QH426-470 - Abstract
The chromosomes of multicellular animals are organized into a series of topologically independent looped domains. This domain organization is critical for the proper utilization and propagation of the genetic information encoded by the chromosome. A special set of architectural elements, called boundaries or insulators, are responsible both for subdividing the chromatin into discrete domains and for determining the topological organization of these domains. Central to the architectural functions of insulators are homologous and heterologous insulator:insulator pairing interactions. The former (pairing between copies of the same insulator) dictates the process of homolog alignment and pairing in trans, while the latter (pairing between different insulators) defines the topology of looped domains in cis. To elucidate the principles governing these architectural functions, we use two insulators, Homie and Nhomie, that flank the Drosophila even skipped locus. We show that homologous insulator interactions in trans, between Homie on one homolog and Homie on the other, or between Nhomie on one homolog and Nhomie on the other, mediate transvection. Critically, these homologous insulator:insulator interactions are orientation-dependent. Consistent with a role in the alignment and pairing of homologs, self-pairing in trans is head-to-head. Head-to-head self-interactions in cis have been reported for other fly insulators, suggesting that this is a general principle of self-pairing. Homie and Nhomie not only pair with themselves, but with each other. Heterologous Homie-Nhomie interactions occur in cis, and we show that they serve to delimit a looped chromosomal domain that contains the even skipped transcription unit and its associated enhancers. The topology of this loop is defined by the heterologous pairing properties of Homie and Nhomie. Instead of being head-to-head, which would generate a circular loop, Homie-Nhomie pairing is head-to-tail. Head-to-tail pairing in cis generates a stem-loop, a configuration much like that observed in classical lampbrush chromosomes. These pairing principles provide a mechanistic underpinning for the observed topologies within and between chromosomes.
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- 2016
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210. Onychomycosis: Potential of Nail Lacquers in Transungual Delivery of Antifungals
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Nida Akhtar, Hemlata Sharma, and Kamla Pathak
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Medicine ,Science - Abstract
Onychomycosis constitutes the most common fungal infection of the nail (skin beneath the nail bed) that affects the finger as well as toe nails. It is an infection that is initiated by yeasts, dermatophytes, and nondermatophyte molds. Nail lacquers are topical solutions intended only for use on fingernails as well as toenails and have been found to be useful in the treatment of onychomycosis. Thus, in the present review an attempt has been made to focus on the treatment aspects of onychomycosis and the ungual delivery of antifungals via nail lacquer. Several patents issued on nail lacquer till date have also been discussed. Penetration efficiency was assessed by several researchers across the human nail plate to investigate the potentiality of nail lacquer based formulations. Various clinical trials have also been conducted in order to evaluate the safety and efficacy of nail lacquers in delivering antifungal agents. Thus, it can be concluded that nail lacquer based preparations are efficacious and stable formulations. These possess tremendous potential for clinical topical application to the nail bed in the treatment of onychomycosis.
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- 2016
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211. Dermatoglyphics: A Diagnostic Tool to Predict Diabetes
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Manoj Kumar Sharma and Hemlata Sharma
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dermatoglyphics ,palmer ridges ,flexion creases ,diabetes ,finger prints ,Medicine - Abstract
Introduction: The study of the epidermal ridges on the volar aspect of the hands and feet which form a variety of pattern configurations is called “DERMATOGLYPHICS”. All configurations are laid down permanently from the 3rd month of the intra-uterine life and they remain unchanged throughout the life. A positive association of the dermatoglyphic features with different diseases like diabetes, mongolism, schizophrenia and leprosy have been well documented in recent years. Methods: In the present study, 50 diabetic cases and 50 controls were selected from the SMS Hospital, Jaipur, India for the establishment of the correlation between the two groups by checking for the presence and absence of any dermatoglyphic pattern. Hand prints were taken by Indian ink methods and examined for Total Finger Ridge Count (TFRC), Absolute Finger Ridge Count (AFRC), (a-b) ridge count , distal and lateral deviation (quantitative parameter) and digital and palmer pattern frequency, lateral deviation, angles and the C- line pattern frequency (qualitative parameter). Aim: The aim of the present was to evaluate the dermatoglyphic features and the specific variations which were to be used as diagnostic tools for an economic and early detection of diabetes. Results and Conclusion: The TFRC, AFRC, and the (a-b) ridge count were higher in all the patients but they were statistically insignificant. The ‘atd’ angles in the hands of both sides in the patients were increased in all the groups, except in males (left side), but they differed significantly on the right side (overall, p
- Published
- 2012
212. Implant Surface Modifications: A Review
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Hemlata Garg, Gaurav Bedi, and Arvind Garg
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hydrophilic surface laser etching nanotitania osseointegration aniodized implants biotolerant ,Medicine - Abstract
The aim of the present review was to elaborate on the surface modifications of biomaterials which are used in implant dentistry. The ongoing studies on the clinical and laboratory phases and on the biomaterial sciences have largely aimed at invoking a stronger bone response and an earlier and longer functional loading. Surgical grafting procedures to improve the bone bed are used to create an ideal environment for the implant functioning. The implant selection which is based on the available bone, is also an important determiner of the long term clinical success. The interfacial zone between the implant and the bone is composed of a relatively thin layer (
- Published
- 2012
213. Evaluation of the Haematological Responses to High Nitrate Exposure in Rabbits
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Manoj Kumar Sharma and Hemlata Sharma
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nitrate ,nitrite ,blood ,methemoglobin ,toxicity ,rabbits ,Medicine - Abstract
Introduction: Nitrate is a common pollutant in the drinking water of Rajasthan as well as in the rest of India. The maximum permissible limit for the nitrate ion in drinking water has been set at 50 mg/l by the WHO and at 45 mg/ l by the Bureau of Indian Standards. In the body, nitrate is reduced to nitrite and the absorption of nitrite leads to methemoglobinaemia. Nitrate toxicity has been observed frequently in ruminants which has been fed on a variety of plant materials which had high nitrate content. Aim: The present study examined a possible correlation between the nitrate concentration in drinking water and the blood profile changes in rabbits. Materials and Methods: Rabbits were selected for the study because the pH of their stomachs was similar to that of human beings. We included 5 groups of rabbits, with 2 rabbits in each group. The groups were named A, B, C, D and E respectively. The nitrate concentrations in the drinking water were 45 mg/l, 100 mg/ l,200 mg / l,400 mg / l and 500 mg/ l in the groups A to E respectively. The group A was considered as the control group. After 120 days of the ingestion of sodium nitrate in drinking water, blood samples were collected from the rabbits of each group and were observed. Results and Conclusion: The maximum haematological parameters such as WBC, lymphocytes, MCHC, RBC, Hb and basophills showed decreased values in the higher groups as compared to the values of the control group. The PCV and MCV showed increased values in the higher groups as compared to the values of the control group. The present study indicated that the symptoms of nitrate toxicity were associated with the low oxygen carrying capacity of blood in the affected animals. Nitrate toxicity is a potential health hazard and the scarcity of data on the nitrate toxicity in blood created an interest in attempting the present study.
- Published
- 2012
214. HER 2 status in invasive breast cancer: Immunohistochemistry, fluorescence in-situ hybridization and chromogenic in-situ hybridization
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Hemlata S Shirsat, Sridhar Epari, Tanuja Shet, Rajani Bagal, Rohini Hawaldar, and Sangeeta B Desai
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Breast cancer ,chromogenic in-situ hybridization ,fluorescence in-situ hybridization ,HER2/neu ,immunohistochemistry ,Pathology ,RB1-214 ,Microbiology ,QR1-502 - Abstract
Introduction : HER2/neu gene status in breast cancers can be evaluated by targeting protein and gene - immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH). Recent studies have shown chromogenic in-situ hybridization (CISH) as a relatively cheaper alternative. Materials and Methods : Forty-three nonconsecutive, randomly selected primary invasive breast cancer cases were evaluated for c-erbB-2 (HER2 protein) by IHC and gene amplification by FISH and CISH. Results of each of the same were compared. Results : CISH showed approximately 90% and 100% concordance for IHC negative and positive cases, respectively; while approximately 94.4% and 91% concordance with FISH amplified and non-amplified cases, respectively. Conclusion : This study showed feasibility of incorporation of CISH as a low cost option in routine management of breast carcinoma in the Indian setting. Secondly, reconfirmation of IHC negative and positive cases can be done by CISH.
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- 2012
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215. Molecular characterization of coldwater fishes of district Uttarkashi, Uttarakhand using DNA Barcoding
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Madhu Thapliyal, Hemlata Pokhriyal, Bipin K. Sati, N.S. Nagpure, Mahender Singh, and Ashish Thapliyal
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DNA Barcoding ,Species identification ,biodiversity ,molecular taxonomy ,Garhwal Himalaya ,Uttarkashi ,Environmental sciences ,GE1-350 - Abstract
We explored fish fauna Ganga and Yamuna river in Uttarkashi district of Uttarakhand, to establish the molecular taxonomy database. A total of 133 samples were collected from various sampling sites along the entire stretch of rivers in district Uttarkashi. A region of cytochrome c-oxidase unit I (COI) gene (655 bp) was amplified using PCR and sequenced (DNA Barcoded). All the sequences have been uploaded into the NCBI GenBank (accession number assigned). Analysis of data generated showed that these 133 samples belonged to 22 species of 4 orders, 14 genera and 8 families. The genetic variability (K2P distance) distribution analysis was also carried out. The average mean distance of 22 species is 0.219 with 0.014 standard error. The mean genetic distance between 22 species ranged from 0.010%-0.362% while the mean genetic distance within the species ranged from 0.0006%- 0.0048%. The lowest pairwise genetic distance observed in Schizothorax sinuatus and Schizothorax progastus i.e. 0.010% with 0.003 standard error indicating a closer phylogenetic relationship between Schizothorax sinuatus and Schizothorax progastus than other species which was confirmed by the genetic distance data. Maximum divergence were observed between Danio devario and Channa gachua i.e. 0.362% with 0.028 standard error. The maximum sequence divergence within the species is observed in Barilius bendelisis with 0.0048% while minimum sequence divergence is observed in Tor putitora with 0.0006 of cyprinidae family. Our data suggests that there is high inter-specific sequence divergence as compared to intra-specific sequence divergence and also conclude that COI sequencing (barcoding) was found to be suitable for the identification of fresh water fish species.
- Published
- 2015
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216. Double Tension Band Osteosynthesis in Inter-Condylar Humeral Fractures
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Santosh Lakshmanrao Munde, Mohd Javed Bhatti, R.C. Siwach, Anil Gulia, Z.S.Kundu, Sanjeev Bansal, Sanjay Middha, and Hemlata T Kamra
- Subjects
cost effectiveness ,distal humerus ,tourniquet time ,Medicine - Abstract
Introduction: Intercondylar humerus fractures are uncommon in orthopaedic practice. The treatment for the same has been described in the literature and include paragonal and orthogonal fixation by using plates. Tension band wiring as a treatment for the same is sparsely described in the literature. Aim: To evaluate the effectiveness of "Double Tension Band wiring" method for the treatment of intercondylar fractures of humerus and compare the results with studies involving treatment with locked plates. Materials and Methods: Twenty patients, all presenting with fresh fractures of the distal humerus, treated with double tension band wiring were retrospectively evaluated over a period of three years. Fractures were classified according to Jupiter classification of distal humeral fractures. There were 5 high T fractures, 13 low T fractures and 2 Y fractures. According to AO classification, all were C1 fractures. Average age of the patients was 56.20 years (32-70 years). There were 13 males and 07 females. Results: Out of 20 cases treated with this method, rigid fixation and union was achieved in all of them. The average tourniquet time was 69 minutes with minimum of 50 minutes and maximum of 120 minutes. Radiological union was achieved at an average of 10.8 weeks (8-14weeks). Average range of motion was 104.5 degrees with maximum range of motion 120 degrees (10-130) and minimum of 70 degrees (30-100). Excellent or good results were obtained in 80% of the patients in our study. Conclusion: Double tension band is a reliable, less demanding and cost effective method of fixation of intercondylar fractures of humerus.
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- 2015
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217. Conservation Strategies for the Threatened Quercus Semecarpifolia Sm. A Himalayan Timberline Oak
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Hemlata BISHT, Vinay PRAKASH, and Anant Ram NAUTIYAL
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Q. semecarpifolia ,in-situ regeneration ,microclimate ,conservation ,ecosystem restoration ,radicle autonomy ,Fine Arts ,Arts in general ,NX1-820 - Abstract
Quercus semecarpifolia Sm. is a temperate, timberline, multipurpose oak species. It plays an important role in the Himalayan ecosystem. Human pressure, predation, short-lived acorns, failure of good seed crop every year, poor regeneration, desiccation, frost sensitivity and climate change may lead to complete extinction of the species in a near future. Immediate attention to conservation and restoration measures of the Himalayan ecosystem, in which this species grows, is required. Thus, an experiment was designed to analyze the role of planting stock and micro-sites for the regeneration of Q. semecarpifolia in-situ. For that purpose, 16 microsites with presence/absence of litter, canopy and sunlight were identified, where seeds/propagules were planted. The presence of litter, canopy and sunlight influenced the seedling production, mainly impairing the processes, leading to the expansion in diameter of the radicle, causing shoot/root emergence. Radicle emergence took place in all the seeds immediately after shedding but only 20% of seedlings recovered; however, when the stored seeds were sown as soon as the emerging radicle attained 10-15cm in length and 2-3cm in diameter, 80% of seedlings were recovered. Surprisingly, after being detached from the seed the swollen radicle acted as a propagule and produced 80% seedlings irrespective of the microsites; however, radicles detached prior to diameter expansion failed to produce seedlings which is a crucial insight for promoting seedling production.
- Published
- 2011
218. Fast disintegrating tablets: Opportunity in drug delivery system
- Author
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Ved Parkash, Saurabh Maan, Deepika, Shiv Kumar Yadav, Hemlata, and Vikas Jogpal
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Fast dissolving tablets ,freeze drying ,spray drying ,taste masking ,Therapeutics. Pharmacology ,RM1-950 ,Pharmacy and materia medica ,RS1-441 - Abstract
Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray drying and use of disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and dissolution are also discussed.
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- 2011
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219. t-EER: Parameter-Free Tandem Evaluation of Countermeasures and Biometric Comparators.
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Tomi H. Kinnunen, Kong Aik Lee, Hemlata Tak, Nicholas W. D. Evans, and Andreas Nautsch
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- 2024
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220. Anesthetic management for cesarean section in chronic renal failure
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Hemlata Kapoor, Kuzhupully Parambhil Krishnan, and Kutty Rajeev
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Anesthesia ,chronic renal insufficiency ,pregnancy ,Anesthesiology ,RD78.3-87.3 ,Gynecology and obstetrics ,RG1-991 - Abstract
Pregnancy in chronic kidney disease is rare and is associated with high incidence of maternal and fetal morbidity. More women with chronic renal failure, due to better management and treatment modalities are able to conceive and carry on their pregnancy and delivery. The case report describes anesthesia for caesarean section in a parturient with chronic renal failure and reviews the literature.
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- 2014
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221. Concomitant Takayasu arteritis and Cushing syndrome in a child undergoing open adrenalectomy: An anaesthetic challenge
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Hemlata and Kamal Kishore
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Adrenalectomy ,anaesthesia ,Cushing′s syndrome ,Takayasu′s arteritis ,Anesthesiology ,RD78.3-87.3 - Abstract
Takayasu′s arteritis (TA) is a rare, chronic progressive panendarteritis involving the aorta and its main branches. Anaesthesia for patients with TA is complicated by their severe uncontrolled hypertension, end-organ dysfunction, stenosis of major blood vessels, and difficulties encountered in monitoring arterial blood pressure. In a patient with Cushing′s syndrome (CS), the anaesthesiologist needs to deal with volume overload, hyperglycaemia, hypokalaemia, difficult airway and ventilation. Anaesthetic management of a patient with concomitant TA and CS undergoing adrenalectomy has hardly ever been reported. We present the successful anaesthetic management of a 15-year-old child with coexisting TA and CS undergoing open adrenalectomy.
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- 2014
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222. Anaesthetic Management of A Patient with Sturge-Weber Syndrome Undergoing Oophorectomy
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Manju Gandhi, Hemlata Iyer, Herman Sehmbi, and Kavita Datir
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Sturge-Weber Syndrome ,Port Wine Angioma ,Cerebro-Cortical Atrophy ,Propofol ,Anesthesiology ,RD78.3-87.3 - Abstract
The Sturge-Weber Syndrome (SWS) is a neurocutaneous disorder characterized by leptomeningeal and facial angiomas, neurologic and ocular manifestations. We report a case of oophorectomy for ovarian dermoid in a 14 year -old girl who was a diagnosed case of Sturge-Weber Syndrome. General anaesthesia was given for the procedure. The perioperative anaesthestic management is discussed in the present report.
- Published
- 2009
223. On the potential of jointly-optimised solutions to spoofing attack detection and automatic speaker verification
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Ge, Wanying, Tak, Hemlata, Todisco, Massimiliano, and Evans, Nicholas
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Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
The spoofing-aware speaker verification (SASV) challenge was designed to promote the study of jointly-optimised solutions to accomplish the traditionally separately-optimised tasks of spoofing detection and speaker verification. Jointly-optimised systems have the potential to operate in synergy as a better performing solution to the single task of reliable speaker verification. However, none of the 23 submissions to SASV 2022 are jointly optimised. We have hence sought to determine why separately-optimised sub-systems perform best or why joint optimisation was not successful. Experiments reported in this paper show that joint optimisation is successful in improving robustness to spoofing but that it degrades speaker verification performance. The findings suggest that spoofing detection and speaker verification sub-systems should be optimised jointly in a manner which reflects the differences in how information provided by each sub-system is complementary to that provided by the other. Progress will also likely depend upon the collection of data from a larger number of speakers., Comment: Accepted to IberSPEECH 2022 Conference
- Published
- 2022
224. The effect of non-surgical periodontal therapy on salivary IL-6 levels in patients with moderate to severe generalized chronic periodontitis
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Khan, Mahvish, Sharma, Anamika, Sharma, Ananya, Singh, Ganesh, Khan, Saif, Ahmad, Saheem, Alrashidi, Ayshah Aysh Ma’an, Sherwani, Subuhi, Mishra, Hemlata, and Alsulimani, Ahmad
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- 2023
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225. IL10 Variant g.5311A Is Associated with Visceral Leishmaniasis in Indian Population.
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Anshuman Mishra, Sheikh Nizamuddin, Geethika Arekatla, Satya Prakash, Hemlata Dewangan, Abishai Dominic, Abhishek Mishra, Digumarthi V S Sudhakar, Narasimha R Parine, Nitin C Tupperwar, and Kumarasamy Thangaraj
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Medicine ,Science - Abstract
Visceral leishmaniasis (VL) is a multifactorial disease, where the host genetics play a significant role in determining the disease outcome. The immunological role of anti-inflammatory cytokine, Interleukin 10 (IL10), has been well-documented in parasite infections and considered as a key regulatory cytokine for VL. Although VL patients in India display high level of IL10 in blood serum, no genetic study has been conducted to assess the VL susceptibility / resistance. Therefore, the aim of this study is to investigate the role of IL10 variations in Indian VL; and to estimate the distribution of disease associated allele in diverse Indian populations.All the exons and exon-intron boundaries of IL10 were sequenced in 184 VL patients along with 172 ethnically matched controls from VL endemic region of India.Our analysis revealed four variations; rs1518111 (2195 A>G, intron), rs1554286 (2607 C>T, intron), rs3024496 (4976 T>C, 3' UTR) and rs3024498 (5311 A>G, 3' UTR). Of these, a variant g.5311A is significantly associated with VL (χ2=18.87; p =0.00001). In silico approaches have shown that a putative micro RNA binding site (miR-4321) is lost in rs3024498 mRNA. Further, analysis of the above four variations in 1138 individuals from 34 ethnic populations, representing different social and linguistic groups who are inhabited in different geographical regions of India, showed variable frequency. Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes. Our findings suggest that majority of tribal populations of India carry the protected / less severe allele against VL, while risk / more severe allele for leprosy and Behcet's disease. This study has potential implications in counseling and management of VL and other infectious diseases.
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- 2015
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226. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
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Seyung Chung, Sami Dwabe, Yayha Elshimali, Hemlata Sukhija, Clement Aroh, and Jaydutt V Vadgama
- Subjects
Medicine ,Science - Abstract
Colorectal cancer (CRC) is one of the three leading causes for cancer mortality. CRC kills over 600,000 people annually worldwide. The most common cause of death from CRC is the metastasis to distant organs. However, biomarkers for CRC metastasis remain ill-defined. We compared primary and metastatic CRC cell lines for their angiogenesis-protein profiles and intracellular signaling profiles to identify novel biomarkers for CRC metastasis. To this end, we used primary and metastatic CRC cell lines as a model system and normal human colon cell line as a control. The angiogenesis profiles two isogenic CRC cell lines, SW480 and SW620, and HT-29 and T84 revealed that VEGF was upregulated in both SW620 and T84 whereas coagulation factor III, IGFBP-3, DPP IV, PDGF AA/AB, endothelin I and CXCL16 were downregulated specifically in metastatic cell lines. Furthermore, we found that TIMP-1, amphiregulin, endostatin, angiogenin were upregulated in SW620 whereas downregulated in T84. Angiogenin was downregulated in T84 and GM-CSF was also downregulated in SW620. To induce CRC cell metastasis, we treated cells with pro-inflammatory cytokine IL-6. Upon IL-6 treatment, epithelial-mesenchymal transition was induced in CRC cells. When DLD-1 and HT-29 cells were treated with IL-6; Akt, STAT3, AMPKα and Bad phosphorylation levels were increased. Interestingly, SW620 showed the same signal activation pattern with IL-6 treatment of HT-29 and DLD-1. Our data suggest that Akt, STAT3, AMPKα and Bad activation can be biomarkers for metastatic colorectal cancer. IL-6 treatment specifically reduced phosphorylation levels of EGFR, HER2 receptor, Insulin R and IGF-1R in receptor tyrosine kinase array study with HT-29. Taken together, we have identified novel biomarkers for metastatic CRC through the angiogenesis-antibody array and intracellular signaling array studies. Present study suggests that those novel biomarkers can be used as CRC prognosis biomarkers, and as potential targets for the metastatic CRC therapy.
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- 2015
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227. Digital storytelling and community engagement to find missing TB cases in rural Nuh, India
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Quraishi, Subhi, Quraishi, Hilmi, Yadav, Hemlata, Singh, Ayushi, Fasih, Ilmana, Vasquez, Nathaly Aguilera, Huria, Lavanya, Pande, Tripti, Mumba, Olive, Kamineni, Vishnu Vardhan, and Khan, Amera
- Published
- 2022
228. Maxillofacial Prosthetic Materials-An Inclination Towards Silicones
- Author
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Aparajita Mitra, Sunita Choudhary, Hemlata Garg, and Jagadeesh.H.G.
- Subjects
heat-vulcanized silicones ,maxillo-facial materials ,room temperature vulcanized ,silicones ,Medicine - Abstract
There have been constant searches and researches which are taking place in the field of dental materials to best suit the ideal selection criteria to satisfy the functionality, biocompatibility, aesthetics as well as the durability as a maxillofacial material. Among all the different materials, Silicone is the most popularly used, but still studies are carried out to overcome their weaknesses and to come out with a material which can be labeled as the “ideal maxillofacial prosthetic material”. This article comprises the materials which were and are in use and the reason for their unpopularity. It also gives us a scope to understand the major fields where the materials lack and thus needs improvement to render an individual with the best maxillo-facial prosthesis.
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- 2014
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229. Evaluation Profile of Thyroid Nodule by Fnac in the Rural Population of Khanpur Kalan, Sonepat, Haryana
- Author
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Hemlata T Kamra, Ruchi Agarwal, Parveen Rana, Rajnish Kalra, Swarn Kaur, Amrita Duhan, Sanjay Verma, and Deepti Agarwal
- Subjects
autoimmune thyroiditis ,goiter ,post iodinisation ,thyroid ,Medicine - Abstract
Background: Thyroid disease is most common endocrine disorder and is different from other endocrine diseases because of its visible swelling and ease of diagnosis. If left untreated, thyroid disease makes a person more prone for heart disease, infertility and osteoporosis. In India, significant burden of thyroid diseases exist with an estimation of around 42 million cases. The thyroid status and autoimmune status of adult Indian population in the post iodinization phase is largely unknown. Aim: The main objective of this study was to generate valuable epidemiological data regarding the prevalence of thyroid disorders in rural population of Khanpur Kalan, Sonepat in the post-iodinisation era in India. To assess whether thyroid autoimmunity or goitrogens along with environmental factors play role in the development of thyroid.This paper is being presented in view that no such study has been carried out in the rural population of this region in Haryana. Materials and Methods: The present study was conducted in Department of Pathology, Bhagat Phool Singh Medical College for Women, Khanpur Kalan, Sonepat between August 2011 to July 2013. It included retrospective analysis of cytomorphology of fine needle aspiration cytology material of 206 patients presenting with thyroid nodule in the Department of Pathology. Results: The commonest age group affected was 31-40 yrs. The female patients (93.4%) outnumbered the male patients (6.6%). The cytomorphological analysis of 206 patients revealed 190 cases (92.2%) of neoplastic lesions, 10 cases (4.8%) were neoplastic and 6 cases (2.9%) had indeterminate cytomorphology. Maximum number (65.5%) of patients was suffering with goiter followed by lymphocytic thyroiditis (26.2%). Amongst the malignant cases three cases were of papillary carcinoma and one case of medullary carcinoma. Two out of the six cases of follicular neoplasm proved to be follicular adenoma on histopathology. Four patients with high T3 levels were under treatment with neomercazole. They showed change in cytomorphology from hyperplasia to colloid goiter. Only one case of acute suppurative thyroiditis was reported which shows rarity of its type. Conclusion: The increased prevalence of goiter in this post iodinisation era can be attributed to goitrogens, autoimmune thyroid disease and micronutrient deficiency of iron and selenium. Higher prevalence of autoimmune thyroiditis in females is linked with both genetic and environmental factors such as infection, stress.
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- 2014
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230. Histopathological Changes in the Liver of Rabbits Exposed to High Nitrate Ingestion in Drinking Water
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Manoj Kumar Sharma, Hemlata Sharma, and Neelam Bapna
- Subjects
liver ,methaemoglobin ,nitrate ,rabbits ,histopathology ,cyanosis ,nitrite ,Medicine - Abstract
Objectives: In India, especially in Rajasthan, people drink water which contains high level of nitrates and the possibility of finding concentrations of up to 500 mg of nitrate ions per litre of water is not unusual. Excessive use of nitrate fertilisers and herbicides results in accumulation of nitrate in plants and methemoglobinaemia in cattle as consequences of nitrate poisoning. The ingested nitrate is converted to nitrite in the digestive system and it is absorbed in blood, thus causing methemoglobinaemia. Methaemoglobinaemia is not restricted to infants alone, but it is prevalent in higher age groups also. Methods: Therefore, an experimental study was conducted on 10 rabbits which were between three and a half months to four months of age, which had weights which ranged from 1.310 kg to 1.720 kg. Five groups A, B, C,D and E were formed, with two rabbits in each group. The control Group A was given water orally, which had 45 mg/litres of nitrate. Groups B to E (experimental groups) were administered water orally, which had concentrations of 100mg/litre, 200mg/litre, 400mg/litre and 500mg/litre of nitrate respectively, for 120 days. During experimental period, the differences in general behaviour of rabbits were noted. After this, rabbits were anaesthetised and sacrificed according to guidelines of ICMR and their livers were removed and processed for making paraffin sections,. Hematoxyllin and eosin staining was done for microscopic observations. Results: During experimental period, the animals were found to be lethargic on 75th day. Quantity of intake of food and water was not altered in the rabbits which were undergoing experiments in different groups. Rabbits of all groups i.e. A to E showed a continuous increase in heart rate (up to 218/minute in Group E) and respiration rate (up to 84/minute in Group E) respectively. The microscopic study showed mild necrosis of hepatocytes, with infiltration of inflammatory cells in between hepatocytes. In higher groups, the liver showed bridging necrosis and portal triditis. Dilatations of central vein with eosinophilic degeneration were observed in Group E only.
- Published
- 2013
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231. Loose bodies in right elbow joint: Post traumatic? or post infective?
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Hemlata Panwar, V Senthil Kumar, Vivek Trikha, and Arulselvi Subramanian
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Fibrinous loose bodies ,intercondylar fracture ,tubercular arthritis ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Tuberculous osteomyelitis after open fracture is uncommon. Early diagnosis of tubercular arthritis is difficult because of insidious onset, indolent process and mild or non specific local or systemic symptoms. This case report describes the fibrinous loose bodies in elbow joint of a patient who sustained a compound fracture presented with chronic non healing discharging sinus. Intra-operatively some suspected seed like bodies were removed and sent for histopathological examination which showed circumscribed homogenous fibrinous bodies with focal area of hyalinization and few embedded tiny osteolytic fragments. Acid Fast Bacilli staining was positive. The patient had a good recovery after treatment with anti-tuberculosis drugs.
- Published
- 2013
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232. Mapping the antiplatelet effects of clopidogrel and aspirin by modified thromboelastography
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Hemlata, Anupam Verma, and Priti Elhence
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Anesthesiology ,RD78.3-87.3 ,Pharmacy and materia medica ,RS1-441 - Published
- 2013
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- View/download PDF
233. Steatocystoma Multiplex-A Rare Genetic Disorder: A Case Report and Review of the Literature
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Hemlata T. Kamra, Pradeep A. Gadgil, Ajay G. Ovhal, and Rahul R. Narkhede
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steatocystoma ,autosomal dominant ,radiofrequency probe ,Medicine - Abstract
ABSTRACT A 17 years old female presented with multiple asymptomatic cutaneous cysts all over body, sparing the head and neck region. The microscopic examination of the cysts showed the features of steatocystoma multiplex. This disorder, although it is asymptomatic, is a cosmetic threat to the patient . Only a few cases of the patients with an autosomal dominant mutation, who had keratin 17, have been reported. We are reporting here, a case of steatocystoma multiplex in a 17 years old female, along with its review of literature.
- Published
- 2013
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234. Baseline Systems for the First Spoofing-Aware Speaker Verification Challenge: Score and Embedding Fusion
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Shim, Hye-jin, Tak, Hemlata, Liu, Xuechen, Heo, Hee-Soo, Jung, Jee-weon, Chung, Joon Son, Chung, Soo-Whan, Yu, Ha-Jin, Lee, Bong-Jin, Todisco, Massimiliano, Delgado, Héctor, Lee, Kong Aik, Sahidullah, Md, Kinnunen, Tomi, and Evans, Nicholas
- Subjects
Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Deep learning has brought impressive progress in the study of both automatic speaker verification (ASV) and spoofing countermeasures (CM). Although solutions are mutually dependent, they have typically evolved as standalone sub-systems whereby CM solutions are usually designed for a fixed ASV system. The work reported in this paper aims to gauge the improvements in reliability that can be gained from their closer integration. Results derived using the popular ASVspoof2019 dataset indicate that the equal error rate (EER) of a state-of-the-art ASV system degrades from 1.63% to 23.83% when the evaluation protocol is extended with spoofed trials.%subjected to spoofing attacks. However, even the straightforward integration of ASV and CM systems in the form of score-sum and deep neural network-based fusion strategies reduce the EER to 1.71% and 6.37%, respectively. The new Spoofing-Aware Speaker Verification (SASV) challenge has been formed to encourage greater attention to the integration of ASV and CM systems as well as to provide a means to benchmark different solutions., Comment: 8 pages, accepted by Odyssey 2022
- Published
- 2022
235. Anesthetic management of a known case of serotonin syndrome undergoing renal transplant
- Author
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Hemlata Kapoor, Harshal Wagh, Shruti Tapiawala, and Annu Aggarwal
- Subjects
Anesthesiology ,RD78.3-87.3 ,Pharmacy and materia medica ,RS1-441 - Published
- 2016
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236. Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now?
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Patil, Hemlata, Vemula, Sateesh Kumar, Narala, Sagar, Lakkala, Preethi, Munnangi, Siva Ram, Narala, Nagarjuna, Jara, Miguel O., Williams, III, Robert O., Terefe, Hibreniguss, and Repka, Michael A.
- Published
- 2024
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237. A rare case of adult onset retinoblastoma
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Sunil Kumar Singh, Dipankar Das, Harsha Bhattacharjee, Jyotirmay Biswas, Ganesh Kuri, Kasturi Bhattacharjee, Hemlata Deka, and Akshay Chandra Deka
- Subjects
Retinoblastoma ,retinocytoma ,ultrasonography ,Ophthalmology ,RE1-994 - Abstract
Retinoblastoma usually manifests before five years of age. Retinoblastoma in an adult is extremely rare. Twenty-three cases of retinoblastoma in adults 20 years or older have been reported in world literature. We report a case of adult onset retinoblastoma in a 29-year-old female. Our patient had unilateral endophytic retinoblastoma with vitreous seeds and calcification on ultrasonography. She underwent enucleation with silicone ball implantation and the diagnosis was confirmed histopathologically. The diagnosis of retinoblastoma should be kept in mind in cases presenting with a white mass lesion of unknown etiology, in the fundus of an adult.
- Published
- 2011
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238. RNA-seq based transcriptome analysis of hepatitis E virus (HEV) and hepatitis B virus (HBV) replicon transfected Huh-7 cells.
- Author
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Neetu Jagya, Satya Pavan Kumar Varma, Deepshi Thakral, Prashant Joshi, Hemlata Durgapal, and Subrat Kumar Panda
- Subjects
Medicine ,Science - Abstract
Pathogenesis of hepatitis B virus (HBV) and hepatitis E virus (HEV) infection is as varied as they appear similar; while HBV causes an acute and/or chronic liver disease and hepatocellular carcinoma, HEV mostly causes an acute self-limiting disease. In both infections, host responses are crucial in disease establishment and/or virus clearance. In the wake of worsening prognosis described during HEV super-infection over chronic HBV hepatitis, we investigated the host responses by studying alterations in gene expression in liver cells (Huh-7 cell line) by transfection with HEV replicon only (HEV-only), HBV replicon only (HBV-only) and both HBV and HEV replicons (HBV+HEV). Virus replication was validated by strand-specific real-time RT-PCR for HEV and HBsAg ELISA of the culture supernatants for HBV. Indirect immunofluorescence for the respective viral proteins confirmed infection. Transcription profiling was carried out by RNA Sequencing (RNA-Seq) analysis of the poly-A enriched RNA from the transfected cells. Averages of 600 million bases within 5.6 million reads were sequenced in each sample and ∼15,800 genes were mapped with at least one or more reads. A total of 461 genes in HBV+HEV, 408 in HBV-only and 306 in HEV-only groups were differentially expressed as compared to mock transfection control by two folds (p
- Published
- 2014
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239. Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood.
- Author
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Yvonne Vercoulen, Felicitas Bellutti Enders, Jenny Meerding, Maud Plantinga, Elisabeth F Elst, Hemlata Varsani, Christa van Schieveen, Mette H Bakker, Mark Klein, Rianne C Scholman, Wim Spliet, Valeria Ricotti, Hans J P M Koenen, Roel A de Weger, Lucy R Wedderburn, Annet van Royen-Kerkhof, and Berent J Prakken
- Subjects
Medicine ,Science - Abstract
Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored Treg presence and function in peripheral blood and muscle of JDM patients. We analyzed number, phenotype and function of Tregs in blood from JDM patients by flow cytometry and in vitro suppression assays, in comparison to healthy controls and disease controls (Duchenne's Muscular Dystrophy). Presence of Tregs in muscle was analyzed by immunohistochemistry. Overall, Treg percentages in peripheral blood of JDM patients were similar compared to both control groups. Muscle biopsies of new onset JDM patients showed increased infiltration of numbers of T cells compared to Duchenne's muscular dystrophy. Both in JDM and Duchenne's muscular dystrophy the proportion of FOXP3+ T cells in muscles were increased compared to JDM peripheral blood. Interestingly, JDM is not a self-remitting disease, suggesting that the high proportion of Tregs in inflamed muscle do not suppress inflammation. In line with this, peripheral blood Tregs of active JDM patients were less capable of suppressing effector T cell activation in vitro, compared to Tregs of JDM in clinical remission. These data show a functional impairment of Tregs in a proportion of patients with active disease, and suggest a regulatory role for Tregs in JDM inflammation.
- Published
- 2014
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240. KNOWLEDGE ABOUT ANESTHESIA AND PERCEPTION ABOUT ANESTHESIOLOGISTS AMONG PATIENTS AT A RURAL TERTIARY CARE HOSPITAL: A CROSS SECTIONAL SURVEY
- Author
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Birva N Khara, Krutika B Rupera, Kinjal R Gondalia, and Hemlata V Kamat
- Subjects
Anesthesia ,Anesthetist ,knowledge ,perceptions ,Medicine - Abstract
Background: Our patients are not well aware of the role of anesthetist and especially their knowledge is very poor regarding anesthetist commitments within and outside the operation theatre. The present study was conducted to know the awareness and knowledge of the patients about anesthesia and anesthetist. Methodology: The present study was a cross sectional study conducted using predesigned questionnaire containing questions related to the awareness and knowledge of anesthesia among the patients coming for a pre-anesthesia check-up after taking their voluntary informed consent. Results: Only 22% of the cases know correctly that anesthetist is the person who will resuscitate the patients if any mishap occurs in operation theatre. It was observed that 63% of the cases feel that the role of the anesthetist in operation theatre is to put the patient to sleep. The knowledge about the types of anesthesia was present among 170 (56.7%) of the participants. 52% believe that the role of anesthetist is equivalent to that of the surgeon. Significant association was observed between educational status and perception about the anesthetist as a doctor (p
- Published
- 2013
241. Prevalence of Rabies Prophylaxis among Medical Officers: A Cross Sectional Study
- Author
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Jidge, Ashvini C., primary, Rokade, Hemlata G., additional, and Mangulikar, Suresh K., additional
- Published
- 2023
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242. Rice Brown Spot Disease (Helminthosporium oryzae): Ecology, Epidemiology, and Identification Measures
- Author
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Maurya, Amit Kumar, primary, John, Vinny, additional, Pant, Hemlata, additional, and Srivastava, D. K., additional
- Published
- 2023
- Full Text
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243. SASV 2022: The First Spoofing-Aware Speaker Verification Challenge
- Author
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Jung, Jee-weon, Tak, Hemlata, Shim, Hye-jin, Heo, Hee-Soo, Lee, Bong-Jin, Chung, Soo-Whan, Yu, Ha-Jin, Evans, Nicholas, and Kinnunen, Tomi
- Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
The first spoofing-aware speaker verification (SASV) challenge aims to integrate research efforts in speaker verification and anti-spoofing. We extend the speaker verification scenario by introducing spoofed trials to the usual set of target and impostor trials. In contrast to the established ASVspoof challenge where the focus is upon separate, independently optimised spoofing detection and speaker verification sub-systems, SASV targets the development of integrated and jointly optimised solutions. Pre-trained spoofing detection and speaker verification models are provided as open source and are used in two baseline SASV solutions. Both models and baselines are freely available to participants and can be used to develop back-end fusion approaches or end-to-end solutions. Using the provided common evaluation protocol, 23 teams submitted SASV solutions. When assessed with target, bona fide non-target and spoofed non-target trials, the top-performing system reduces the equal error rate of a conventional speaker verification system from 23.83% to 0.13%. SASV challenge results are a testament to the reliability of today's state-of-the-art approaches to spoofing detection and speaker verification., Comment: 5 pages, 2 figures, 2 tables, submitted to Interspeech 2022 as a conference paper
- Published
- 2022
244. Automatic speaker verification spoofing and deepfake detection using wav2vec 2.0 and data augmentation
- Author
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Tak, Hemlata, Todisco, Massimiliano, Wang, Xin, Jung, Jee-weon, Yamagishi, Junichi, and Evans, Nicholas
- Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Sound - Abstract
The performance of spoofing countermeasure systems depends fundamentally upon the use of sufficiently representative training data. With this usually being limited, current solutions typically lack generalisation to attacks encountered in the wild. Strategies to improve reliability in the face of uncontrolled, unpredictable attacks are hence needed. We report in this paper our efforts to use self-supervised learning in the form of a wav2vec 2.0 front-end with fine tuning. Despite initial base representations being learned using only bona fide data and no spoofed data, we obtain the lowest equal error rates reported in the literature for both the ASVspoof 2021 Logical Access and Deepfake databases. When combined with data augmentation,these results correspond to an improvement of almost 90% relative to our baseline system., Comment: Submitted to Speaker Odyssey Workshop 2022
- Published
- 2022
245. SASV Challenge 2022: A Spoofing Aware Speaker Verification Challenge Evaluation Plan
- Author
-
Jung, Jee-weon, Tak, Hemlata, Shim, Hye-jin, Heo, Hee-Soo, Lee, Bong-Jin, Chung, Soo-Whan, Kang, Hong-Goo, Yu, Ha-Jin, Evans, Nicholas, and Kinnunen, Tomi
- Subjects
Computer Science - Sound ,Computer Science - Cryptography and Security ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
ASV (automatic speaker verification) systems are intrinsically required to reject both non-target (e.g., voice uttered by different speaker) and spoofed (e.g., synthesised or converted) inputs. However, there is little consideration for how ASV systems themselves should be adapted when they are expected to encounter spoofing attacks, nor when they operate in tandem with CMs (spoofing countermeasures), much less how both systems should be jointly optimised. The goal of the first SASV (spoofing-aware speaker verification) challenge, a special sesscion in ISCA INTERSPEECH 2022, is to promote development of integrated systems that can perform ASV and CM simultaneously., Comment: Evaluation plan of the SASV Challenge 2022. See this webpage for more information: https://sasv-challenge.github.io
- Published
- 2022
246. Cerebrospinal Fluid Leucine Rich Alpha-2 Glycoprotein in Children with Tubercular Meningitis with their Diagnostic and Prognostic Significance: A Prospective Study: Authors’ Reply
- Author
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Prasad, Rajniti, Verma, Hemlata, Srivastava, Ragini, Aishwarya, and Kumar, Animesh
- Published
- 2024
- Full Text
- View/download PDF
247. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission
- Author
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Karthikeyan, Smruthi, Levy, Joshua I, De Hoff, Peter, Humphrey, Greg, Birmingham, Amanda, Jepsen, Kristen, Farmer, Sawyer, Tubb, Helena M, Valles, Tommy, Tribelhorn, Caitlin E, Tsai, Rebecca, Aigner, Stefan, Sathe, Shashank, Moshiri, Niema, Henson, Benjamin, Mark, Adam M, Hakim, Abbas, Baer, Nathan A, Barber, Tom, Belda-Ferre, Pedro, Chacón, Marisol, Cheung, Willi, Cresini, Evelyn S, Eisner, Emily R, Lastrella, Alma L, Lawrence, Elijah S, Marotz, Clarisse A, Ngo, Toan T, Ostrander, Tyler, Plascencia, Ashley, Salido, Rodolfo A, Seaver, Phoebe, Smoot, Elizabeth W, McDonald, Daniel, Neuhard, Robert M, Scioscia, Angela L, Satterlund, Alysson M, Simmons, Elizabeth H, Abelman, Dismas B, Brenner, David, Bruner, Judith C, Buckley, Anne, Ellison, Michael, Gattas, Jeffrey, Gonias, Steven L, Hale, Matt, Hawkins, Faith, Ikeda, Lydia, Jhaveri, Hemlata, Johnson, Ted, Kellen, Vince, Kremer, Brendan, Matthews, Gary, McLawhon, Ronald W, Ouillet, Pierre, Park, Daniel, Pradenas, Allorah, Reed, Sharon, Riggs, Lindsay, Sanders, Alison, Sollenberger, Bradley, Song, Angela, White, Benjamin, Winbush, Terri, Aceves, Christine M, Anderson, Catelyn, Gangavarapu, Karthik, Hufbauer, Emory, Kurzban, Ezra, Lee, Justin, Matteson, Nathaniel L, Parker, Edyth, Perkins, Sarah A, Ramesh, Karthik S, Robles-Sikisaka, Refugio, Schwab, Madison A, Spencer, Emily, Wohl, Shirlee, Nicholson, Laura, McHardy, Ian H, Dimmock, David P, Hobbs, Charlotte A, Bakhtar, Omid, Harding, Aaron, Mendoza, Art, Bolze, Alexandre, Becker, David, Cirulli, Elizabeth T, Isaksson, Magnus, Schiabor Barrett, Kelly M, Washington, Nicole L, Malone, John D, Schafer, Ashleigh Murphy, Gurfield, Nikos, Stous, Sarah, Fielding-Miller, Rebecca, Garfein, Richard S, Gaines, Tommi, Anderson, Cheryl, and Martin, Natasha K
- Subjects
Biodefense ,Human Genome ,Lung ,Emerging Infectious Diseases ,Vaccine Related ,Biotechnology ,Genetics ,Prevention ,Infection ,Good Health and Well Being ,COVID-19 ,Humans ,RNA ,Viral ,SARS-CoV-2 ,Sequence Analysis ,RNA ,Wastewater ,Wastewater-Based Epidemiological Monitoring ,General Science & Technology - Abstract
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing and/or sequencing capacity, which can also introduce biases1-3. SARS-CoV-2 RNA concentration in wastewater successfully tracks regional infection dynamics and provides less biased abundance estimates than clinical testing4,5. Tracking virus genomic sequences in wastewater would improve community prevalence estimates and detect emerging variants. However, two factors limit wastewater-based genomic surveillance: low-quality sequence data and inability to estimate relative lineage abundance in mixed samples. Here we resolve these critical issues to perform a high-resolution, 295-day wastewater and clinical sequencing effort, in the controlled environment of a large university campus and the broader context of the surrounding county. We developed and deployed improved virus concentration protocols and deconvolution software that fully resolve multiple virus strains from wastewater. We detected emerging variants of concern up to 14 days earlier in wastewater samples, and identified multiple instances of virus spread not captured by clinical genomic surveillance. Our study provides a scalable solution for wastewater genomic surveillance that allows early detection of SARS-CoV-2 variants and identification of cryptic transmission.
- Published
- 2022
248. Nanorod inside hollow-nanosphere structured magnetoelectric nanocatalyst for remotely controlled electrocatalysis assisted environmental remediation
- Author
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Murali, Nandan, Hemlata, Das, Shashank Bhushan, Sharma, Arti, Thattaru Thodikayil, Aishwarya, Minocha, Shilpi, Siddhanta, Soumik, Saha, Sampa, and Betal, Soutik
- Published
- 2024
- Full Text
- View/download PDF
249. An exploration of diffusion-thermo and radiation absorption impacts on non-Newtonian MHD flow towards two distinct geometries with biot number
- Author
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Dharmaiah, G., Balamurugan, K.S., Saxena, Hemlata, Noeiaghdam, S., Fernandez-Gamiz, U., and Dinarvand, S.
- Published
- 2024
- Full Text
- View/download PDF
250. Evaluating the effectiveness of different household washing techniques for removal of insecticides from spinach and chickpea leaves by micellar liquid chromatography
- Author
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Bhamdare, Hemlata, Pahade, Priyanka, Bose, Devasish, Durgbanshi, Abhilasha, Carda-Broch, Samuel, and Peris-Vicente, Juan
- Published
- 2024
- Full Text
- View/download PDF
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