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Knowledge about the occurrence and characteristics of surge-type glaciers is crucial due to the impact of surging on glacier melt and glacier-related hazards. One of the super-clusters of surge-type glaciers is High Mountain Asia (HMA). However, no consistent region-wide inventory of surge-type glaciers in HMA exists. We present a regionally resolved inventory of surge-type glaciers based on their behaviour across High Mountain Asia between 2000 and 2018. We identify surge-type behaviour from surface velocity, elevation and feature change patterns using a multi-factor remote sensing approach that combines yearly ITS_LIVE velocity data, DEM differences and very-high-resolution imagery (Bing Maps, Google Earth). Out of the ≈95 000 glaciers in HMA, we identified 666 that show diagnostic surge-type glacier behaviour between 2000 and 2018, which are mainly found in the Karakoram (223) and the Pamir regions (223). The total area covered by the 666 surge-type glaciers represents 19.5 % of the glacierized area in Randolph Glacier Inventory (RGI) V6.0 polygons in HMA. Only 68 glaciers were already identified as “surge type” in the RGI V6.0. We further validate 107 glaciers previously labelled as “probably surge type” and newly identify 491 glaciers, not previously reported in other inventories covering HMA. We finally discuss the possibility of self-organized criticality in glacier surges. Across all regions of HMA, the surge-affected area within glacier complexes displays a significant power law dependency with glacier length.

Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March–April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique – Hôpitaux de Paris (APHP), the largest multisite public healthcare institution in France. Methods: The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds). Results: Up to a fourth of patients admitted in March–April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March–April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred. Conclusions: The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.

While metal organic frameworks offer highly tunable materials for photocatalytic applications, catalytic site accessibility is a crucial parameter. Here, authors demonstrate selective ligand removal to introduce new active sites and mesopores and to enhance photocatalytic H2 evolution.

We present a microscopic magnetic domain imaging study of single-shot all-optical magnetic toggle switching of a ferrimagnetic Gd26Fe74 film with out-of-plane easy axis of magnetization by X-ray magnetic circular dichroism photoelectron emission microscopy. Individual linearly polarized laser pulses of 800 nm wavelength and 100 fs duration above a certain threshold fluence reverse the sample magnetization, independent of the magnetization direction, the so-called toggle switching. Local deviations from this deterministic behavior close to magnetic domain walls are studied in detail. Reasons for nondeterministic toggle switching are related to extrinsic effects, caused by pulse-to-pulse variations of the exciting laser system, and to intrinsic effects related to the magnetic domain structure of the sample. The latter are, on the one hand, caused by magnetic domain wall elasticity, which leads to a reduction of the domain-wall length at features with sharp tips. These features appear after the optical switching at positions where the line of constant threshold fluence in the Gaussian footprint of the laser pulse comes close to an already existing domain wall. On the other hand, we identify the presence of laser-induced domain-wall motion in the toggle-switching event as a further cause for local deviations from purely deterministic toggle switching.

Partial discharge (PD) measurement of an insulation system is widely used as a diagnostic tool for the quality control of high voltage apparatuses. In ac, the conventional method of PD detection is well established. However, under square voltages such as those generated across power electronic converters, the conventional method cannot discriminate between PDs and switching transients. In this context, this paper demonstrates PD detection under fast-rising square voltages by deploying a photomultiplier tube. For this, an experimental set-up generating unipolar square voltage (USV) waveforms is developed, generating a dV/dt in the range of 10-100 kV/ $\mu \text{s}$ . The device under test (DUT) comprises of needle-barrier plane configuration immersed in dielectric liquids. Barriers differing in permittivity and thicknesses are chosen to test with two types of dielectric liquids, to assess varying conditions. The results thus obtained show a lower partial discharge inception voltage (PDIV) in USV than in bipolar ac for the same DUT specimen. The phase-resolved (PR) PD patterns exhibit a higher PD occurrence during rising and falling front of the USV waveform. Experimental results demonstrate the relevance of the PMT as a PD detector for square voltage waveforms exhibiting high dV/dt in dielectric liquids.

Aging is associated with a decline in muscle mass and function, leading to increased risk for mobility limitations and frailty. Dietary interventions incorporating specific nutrients, such as pea proteins or inulin, have shown promise in attenuating age-related muscle loss. This study aimed to investigate the effect of pea proteins given with inulin on skeletal muscle in old rats. Old male rats (20 months old) were randomly assigned to one of two diet groups for 16 weeks: a ‘PEA’ group receiving a pea-protein-based diet, or a ‘PEA + INU’ group receiving the same pea protein-based diet supplemented with inulin. Both groups showed significant postprandial stimulation of muscle p70 S6 kinase phosphorylation rate after consumption of pea proteins. However, the PEA + INU rats showed significant preservation of muscle mass with time together with decreased MuRF1 transcript levels. In addition, inulin specifically increased PGC1-α expression and key mitochondrial enzyme activities in the plantaris muscle of the old rats. These findings suggest that dietary supplementation with pea proteins in combination with inulin has the potential to attenuate age-related muscle loss. Further research is warranted to explore the underlying mechanisms and determine the optimal dosage and duration of intervention for potential translation to human studies.

The purpose of the present study was to compare attitudes toward body weight and physical activity in both regular-weight and overweight/obese children and adolescents, and assessing relations between attitudes and self-esteem, motivation for physical activity, life satisfaction and level of physical activity. A total of 126 children (Mage = 12.2, SD = 3.4), divided into two subsamples (i.e., overweight/obese, N = 44, and regular-weight), voluntarily participated in the study. A series of univariate analyses of variance was conducted to examine the differences in the study variables across the subsamples. Correlational analyses were conducted to examine the relationships among the variables. The results indicated that obese/overweight participants expressed a more positive implicit attitude toward the thin category than regular-weight participants. Furthermore, among overweight/obese participants, implicit attitude toward physical activity was significantly negatively correlated with explicit attitude toward physical activity and general self-esteem. Significant differences between obese/overweight and regular-weight participants indicated that the status in terms of weight played a key role in attitudes toward the explored constructs.

OBJECTIVE:To determine the characteristics of term infants with persistent pulmonary hypertension of the newborn (PPHN) associated with moderate or severe hypoxic ischemic encephalopathy (HIE). METHODS:We compared infants with and without PPHN enrolled in 2 randomized trials of therapeutic hypothermia: the induced hypothermia trial of cooling to 33.5°C for 72 hours vs normothermia, and the "usual-care" arm (33.5°C for 72 hours) of the optimizing cooling trial. RESULTS:Among 303 infants with HIE from these 2 studies, 67 (22%) had PPHN and 236 (78%) did not. We compared infants with PPHN with those without PPHN. The proportion of patients treated with therapeutic hypothermia was similar in PPHN and no-PPHN groups (66% vs 65%). Medication use during resuscitation (58% vs 44%), acidosis after birth (pH: 7.0 ± 0.2 vs 7.1 ± 0.2), severe HIE (43% vs 28%), meconium aspiration syndrome (39% vs 7%), pulmonary hemorrhage (12% vs 3%), culture-positive sepsis (12% vs 3%), systemic hypotension (65% vs 28%), inhaled nitric oxide therapy (64% vs 3%), and extracorporeal membrane oxygenation (12% vs 0%) were more common in the PPHN group. Length of stay (26 ± 21 vs 16 ± 14 days) and mortality (27% vs 16%) were higher in the PPHN group. CONCLUSIONS:PPHN is common among infants with moderate/severe HIE and is associated with severe encephalopathy, lung disease, sepsis, systemic hypotension, and increased mortality. The prevalence of PPHN was not different between those infants receiving therapeutic hypothermia at 33.5°C in these 2 trials (44/197 = 22%) compared with infants receiving normothermia in the induced hypothermia trial (23/106 = 22%).

The current paper studies the dynamics and age of the Triangle du Tacul (TDT) ice apron, a massive ice volume lying on a steep high-mountain rock wall in the French side of the Mont-Blanc massif at an altitude close to 3640 m a.s.l. Three 60 cm long ice cores were drilled to bedrock (i.e. the rock wall) in 2018 and 2019 at the TDT ice apron. Texture (microstructure and lattice-preferred orientation, LPO) analyses were performed on one core. The two remaining cores were used for radiocarbon dating of the particulate organic carbon fraction (three samples in total). Microstructure and LPO do not substantially vary with along the axis of the ice core. Throughout the core, irregularly shaped grains, associated with strain-induced grain boundary migration and strong single maximum LPO, were observed. Measurements indicate that at the TDT ice deforms under a low strain-rate simple shear regime, with a shear plane parallel to the surface slope of the ice apron. Dynamic recrystallization stands out as the major mechanism for grain growth. Micro-radiocarbon dating indicates that the TDT ice becomes older with depth perpendicular to the ice surface. We observed ice ages older than 600 year BP and at the base of the lowest 30 cm older than 3000 years.

ObjectiveThe aim of the present study was to explore the role of stress, recovery, and coping on table-tennis athlete burnout symptoms in considering both the roles of individual and contextual (training center) factors.MethodsOne hundred and fifty-nine youth elite table-tennis players (Mage = 14.07, SD = 2.13) involved in 15 intensive training centers completed self-report questionnaires and socio-demographic data.ResultsWhen time 1 (T1) levels 1 (individual) and 2 (training group, contextual factor) stress, recovery, and coping were simultaneously entered as predictors of each of the three burnout symptoms (physical and emotional exhaustion, sport devaluation, reduced accomplishment) at T2 (controlling for levels 1 and 2 burnout at T1), the results of multilevel analyses revealed that: (a) T1 level 1 recovery significantly negatively predicted T2 reduced accomplishment (β = −0.23, p = 0.03); (b) T1 level 2 disengagement-oriented coping significantly negatively predicted T2 reduced accomplishment (β = −0.71, p = 0.03); and (c) T1 level 2 task-oriented coping marginally significantly positively predicted T2 physical and emotional exhaustion (β = 0.99, p = 0.06).ConclusionResults of the present study provided evidence for the usefulness to disentangle the variances attributable to the individual (level 1) and contextual (level 2; training group) levels of the predictors (recovery, stress and coping) of athlete burnout. Moreover, rather than examining the antecedent role of stress on athlete burnout, it could be particularly fruitful to explore theoretical constructs able to annihilate the maladaptive effects of chronic stress such as coping and recovery.

Leg ulcers are a major complication of sickle cell disease (SCD). They are particularly challenging to treat and innovative therapies are needed. We previously showed that the healing of SCD ulcers is delayed because of decreased angiogenesis. During pregnancy, fetal microchimeric cells (FMC) transferred to the mother are recruited to maternal wounds and improve angiogenesis. After delivery, FMC persist in maternal bone marrow for decades. Here, we investigated whether fetal cells could also improve SCD ulcers in the post-partum setting. We found that skin healing was similarly improved in post-partum mice and in pregnant mice, through increased proliferation and angiogenesis. In a SCD mouse model that recapitulates refractory SCD ulcers, we showed that the ulcers of post-partum SCD mice healed more quickly than those of virgin mice. This was associated with the recruitment of fetal cells in maternal wounds where they harbored markers of leukocytes and endothelial cells. In a retrospective cohort of SCD patients, using several parameters we found that SCD women who had ever had a baby had less of a burden related to leg ulcers compared to nulliparous women. Taken together, these results indicate that healing capacities of FMC are maintained long after delivery and may be exploited to promote wound healing in post-partum SCD patients.

The study aims at reconciling contrasting productive and environmental goals of agricultural policies at a given budget in the context of climate change. Based on a quantitative bioeconomic model integrating interdependencies between agricultural systems and agroecosystems, we compare the impacts of 4 contrasted public policy scenarios based either on productive (food or energy) or environmental goals (pollution reduction or ecosystem state) on a set of 18 bioeconomic indicators. We run the policy scenarios under two contrasted climate change scenarios to investigate their robustness. We confirm that it is possible to achieve productive and environmental goals with the on-going budget of European agricultural policy. Synergies between productive and environmental performances exist even if they are not trivial nor systematic. More precisely, an agricultural public policy which focuses on energy production might offer a good compromise regarding the different facets of agricultural landscapes. The Pollution scenario constitutes a credible environmentally oriented alternative even if it remains slightly less competitive regarding both ecological and economic sides than an energy-oriented policy. Eventually, our analysis shows that our conclusions are robust to climate change, suggesting that adequate agricultural public policies might attenuate climate change effects when considering intermediary climate change scenarios.

Fishing is a risky activity that has been mainly studied in ergonomics in order to optimize safety on board. The current ecological situation has led us to take an interest in a new way of fishing in order, among other things, to design more environmentally friendly fishing gear. Until now, no study has focused on how fishermen use fishing gear. Based on in situ observations on board two fishing boats and on explicitating self-confrontation interviews with four sailors, this study describes the use of fishing nets at different levels of the fishing activity: macro, meso and micro. It highlights the mechanical stress suffered by fishing nets and the patterns of use mobilized by the deckhands during the unmeshing of the catch. The results help to enrich the specifications for the design of biodegradable fishing gear, to enlighten the design teams on real fishing activity, and to build an environment facilitating the transition from current fishing practices to more sustainable ones.

Recent significant progress in Virtual Reality (VR) applications and environments raised several challenges. They proved to have side effects on specific users, thus reducing the usability of the VR technology in some critical domains, such as flight and car simulators. One of the common side effects is cybersickness. Some significant commonly reported symptoms are nausea, oculomotor discomfort, and disorientation. To mitigate these symptoms and consequently improve the usability of VR systems, it is necessary to predict the incidence of cybersickness. This paper proposes a machine learning approach to VR’s cybersickness prediction based on physiological and subjective data. We investigated combinations of topological data analysis with a range of classifier algorithms and assessed classification performance. The highest performance of Topological Data Analysis (TDA) based methods was achieved in combination with SVMs with Gaussian RBF kernel, indicating that Gaussian RBF kernels provide embeddings of physiological time series data into spaces that are rich enough to capture the essential geometric features of this type of data. Comparing several combinations with feature descriptors for physiological time series, the performance of the TDA + SVM combination is in the top group, statistically being on par or outperforming more complex and less interpretable methods. Our results show that heart rate does not seem to correlate with cybersickness.

The electrochemical and mechanical behaviour of 18,650 Li-ion cells subjected to abusive overcharge has been studied in constant current and constant voltage mode. The results from the cell deformation monitoring via a rectangular rosette strain gauges indicate an over-swelling process starting shortly after the cell voltage increases above 4.2 V. The acoustic ultrasound interrogation measurement and data treatment using clustering and mapping software, carried out in parallel, showed an abnormal evolution of the signals’ power density spectral patterns, suggesting changes in the structure of the cell jellyroll induced by the overcharge reactions. The increase in cell skin temperature due to the overcharge process starts considerably later. The results suggest that the monitoring of the mechanical behaviour of cylindrical-format Li-ion cells can be used for the detection and alerting of early overcharge safety events.

The detection and quantification of fractures in rocks, as well as the detection of lithological changes, are of particular interest in scientific fields, such as construction materials, geotechnics, reservoirs and the diagnostics of dielectric composite materials and cultural heritage objects. Therefore, different methods and techniques have been developed and improved over the years to provide solutions, e.g., seismic, ground-penetrating radar and X-ray microtomography. However, there are always trade-offs, such as spatial resolution, investigated volume and rock penetration depth. At present, high-frequency radars (>60 GHz) are available on the market, which are compact in size and capable of imaging large areas in short periods of time. However, the few rock applications that have been carried out have not provided any information on whether these radars would be useful for detecting fractures and lithological changes in rocks. Therefore, in this work, we performed different experiments on construction and reservoir rocks using a frequency-modulated continuous wave radar working at 300 GHz to evaluate its viability in this type of application. The results showed that the radar quantified millimeter fractures at a 1 cm rock penetration depth with a sensitivity of 500 μm. Furthermore, lithological changes were identified, even when detecting interfaces generated by the artificial union of two samples from the same rock.

Objectives: Isoniazid-monoresistant tuberculosis (HR-TB) is the most prevalent form of drug-resistant TB worldwide and in France and is associated with poorer treatment outcomes compared with drug-susceptible TB (DS-TB). The objective of this study was to determine the characteristics of HR-TB patients in France and to compare outcomes and safety of treatment for HR-TB and DS-TB. Methods: We performed a case-control multicenter study to identify risk factors associated with HR-TB and compare treatment outcomes and safety between HR-TB patients and DS-TB patients. Results: Characteristics of 99 HR-TB patients diagnosed and treated in the university hospitals of Paris, Lille, Caen and Strasbourg were compared with 99 DS-TB patients. Female sex (OR = 2.2; 1.0–4.7), birth in the West-Pacific World Health Organization region (OR = 4.6; 1.1–18.7) and resistance to streptomycin (OR = 77.5; 10.1–594.4) were found to be independently associated with HR-TB. Rates of treatment success did not differ significantly between HR-TB and DS-TB. Conclusions: Factors associated with HR-TB are not significant enough to efficiently screen TB patients at risk of HR-TB. The systematic implementation of rapid molecular testing on clinical samples remains the only effective way to make the early diagnosis of HR-TB and adapt treatment.

(1) Background: Despite health benefits of engaging in regular physical activity (PA), adolescents fail to achieve the recommended PA practice (especially among girls with low socio-economic position). Researchers have been prompted to adopt models of social cognition to help identify the role of psychological factors in influencing PA and sedentary behaviors. Thus, this study examined the effects of an intervention promoting PA, reducing sedentary activity among adolescent girls from low-incomes communities, and explored the relationships between core constructs of salient theoretical frameworks (self-determination theory, theory of planned behavior, implicit and explicit attitude towards PA, and sedentary behaviors); (2) Methods: An intervention was delivered to 28 adolescent girls. They reported their scores on a variety of core psychological constructs grounded within the aforementioned theoretical frameworks as well as on several outcomes, such as objective PA (pedometers) and perceived mental and physical health. These scores were gathered both before and after the 8-weeks program; (3) Results: Results revealed changes on external regulation and implicit attitudes toward sedentary behaviors from before to after the program. However, objective PA behavior did not change; (4) Conclusions: Future studies are encouraged to further explore mechanisms of behavior change derived from integrated and socio-ecological theories.

Tree rings are a crucial archive for Common Era climate reconstructions, but the degree to which methodological decisions influence outcomes is not well known. Here, the authors show how different approaches taken by 15 different groups influence the ensemble temperature reconstruction from the same data.

Abstract Learning biology, and in particular systematics, requires learning a substantial amount of specific vocabulary, both for botanical and zoological studies. While crucial, the precise identification of structures serving as evolutionary traits and systematic criteria is not per se a highly motivating task for students. Teaching this in a traditional teaching setting is quite challenging especially with a large crowd of students to be kept engaged. This is even more difficult if, as during the COVID‐19 crisis, students are not allowed to access laboratories for hands‐on observation on fresh specimens and sometimes restricted to short‐range movements outside their home. Here, we present QuoVidi, a new open‐source web platform for the organization of large‐scale treasure hunts. The platform works as follows: students, organized in teams, receive a list of quests that contain morphologic, ecologic, or systematic terms. They have to first understand the meaning of the quests, then go and find them in the environment. Once they find the organism corresponding to a quest, they upload a geotagged picture of their finding and submit this on the platform. The correctness of each submission is evaluated by the staff. During the COVID‐19 lockdown, previously validated pictures were also submitted for evaluation to students that were locked in low‐biodiversity areas. From a research perspective, the system enables the creation of large image databases by the students, similar to citizen science projects. Beside the enhanced motivation of students to learn the vocabulary and perform observations on self‐found specimens, this system allows instructors to remotely follow and assess the work performed by large numbers of students. The interface is freely available, open‐source and customizable. Unlike existing naturalist platforms, allows the educators to fully customize the quests of interest. This enables the creation of multiple teaching scenarios, without being bound to a fixed scope. QuoVidi can be used in other disciplines with adapted quests and we expect it to be of interest in many classroom settings.

Using data from the Planck satellite, we study the statistical properties of interstellar dust polarization at high Galactic latitudes around the south pole (b

Using data from the Planck satellite, we study the statistical properties of interstellar dust polarization at high Galactic latitudes around the south pole (b

Background:. Psoriasis is a common chronic inflammatory skin disease with an exceptionally high burden for women. Objective:. Sex-dependent differences in disease manifestation, severity, treatment choices, subjective disease perception, and the impact on quality of life and risk factors are described and comprehensively discussed. Methods:. A literature search was conducted using MEDLINE (PubMed) and the Cochrane Library for systematic reviews to investigate the challenges in treating women with psoriasis. Results and conclusions:. The incidence, prevalence, and manifestation of psoriasis of the skin are similar between different sexes. Genetic and environmental factors such as obesity and metabolic syndrome are risk factors and are not equally relevant or pronounced in women and men. Overall, women have a lower disease severity measured by the Psoriasis Area Severity Index, which is associated with a higher impairment of their life quality measured by the Dermatology Life Quality Index compared with men. In addition, women with psoriasis are more likely to have depression than men. Hormonal factors affect psoriasis, with a correlation of high estrogen levels and improvement of psoriasis. Data regarding differences in prescribing patterns of systemic treatments and the severity of psoriasis are not entirely consistent. Registry studies show that men tend to have more severe psoriasis and, in some cases, are prescribed systemic therapies more frequently. Women tend to respond better to systemic treatments and to experience more adverse events. Treatment options are the same for both sexes, except during pregnancy and lactation. Various treatment options are contraindicated due to fear of fetal or neonate harm and lack of data. Topical steroids can be prescribed with a high degree of safety during pregnancy. For other topical therapies (calcineurin inhibitors and vitamin D analogs), no studies of adverse effects in pregnancy are available, and safety data mainly stem from studies examining effects after systemic administration. Antitumor necrosis factor monoclonal antibodies (except for certolizumab pegol) have been associated with a possible increased risk of preterm birth, low gestational age, and cesarean deliveries. Prospective data on the safety of biologics other than antitumor necrosis factor-alpha antibodies to accurately assess whether novel biologics (eg, anti-interleukin 17, 12/23, 23) can be used for systemic therapy in pregnancy are lacking or currently being conducted.

This research aim to investigate the effects of motor imagery (MI), focused on the trajectory of the ball and the target area, and self-talk (motivational function) before the actual strike on the performance of the service in skilled tennis players. Thirty-three participants (6 females and 27 males, Mage = 15.9 years), competing in regional to national competitions, were randomly divided into three groups: Control, MI, and MI + self-talk. They performed a pre-test (25 first service), 20 acquisition sessions (physical trial, physical trial + MI and physical trial + MI + self-talk), and a post-test similar to the pre-test, in match situations. The percentage of the first service, their speed, and the efficiency scores, evaluated by experts, were use as dependent variables and indicators of performance. While there was no difference in service speed ( p > 0.05), this study showed an improvement in the first service percentage and efficiency (all ps

ABSTRACT Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), one of the deadliest infectious diseases. The alarming health context coupled with the emergence of resistant M. tuberculosis strains highlights the urgent need to expand the range of anti-TB antibiotics. A subset of anti-TB drugs in use are prodrugs that require bioactivation by a class of M. tuberculosis enzymes called Baeyer-Villiger monooxygenases (BVMOs), which remain understudied. To examine the prevalence and the molecular function of BVMOs in mycobacteria, we applied a comprehensive bioinformatic analysis that identified six BVMOs in M. tuberculosis, including Rv3083 (MymA), Rv3854c (EthA), Rv0565c, and Rv0892, which were selected for further characterization. Homology modeling and substrate docking analysis, performed on this subset, suggested that Rv0892 is closer to the cyclohexanone BVMO, while Rv0565c and EthA are structurally and functionally similar to MymA, which is by far the most prominent type I BVMO enzyme. Thanks to an unprecedented purification and assay optimization, biochemical studies confirmed that all four BVMOs display BV-oxygenation activity. We also showed that MymA displays a distinctive substrate preference that we further investigated by kinetic parameter determination and that correlates with in silico modeling. We provide insights into distribution of BVMOs and the structural basis of their substrate profiling, and we discuss their possible redundancy in M. tuberculosis, raising questions about their versatility in prodrug activation and their role in physiology and infection. IMPORTANCE Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death worldwide. The rise in drug resistance highlights the urgent need for innovation in anti-TB drug development. Many anti-TB drugs require bioactivation by Baeyer-Villiger monooxygenases (BVMOs). Despite their emerging importance, BVMO structural and functional features remain enigmatic. We applied a comprehensive bioinformatic analysis and confirmed the presence of six BVMOs in M. tuberculosis, including MymA, EthA, and Rv0565c—activators of the second-line prodrug ethionamide—and the novel BVMO Rv0892. Combining in silico characterization with in vitro validation, we outlined their structural framework and substrate preference. Markedly, MymA displayed an enhanced capacity and a distinct selectivity profile toward ligands, in agreement with its catalytic site topology. These features ground the molecular basis for structure-function comprehension of the specificity in these enzymes and expand the repertoire of BVMOs with selective and/or overlapping activity for application in the context of improving anti-TB therapy.