Search

Purpose: Massive accumulation of neutral lipids in Bruch’s membrane (BrM) with concomitantly increased hydraulic resistivity and oxidative stress induction is a major age change in the eye and an important pathogenic factor for the development and progression of age-related macular degeneration.[for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Background: Our previous studies suggested that apolipoprotein (Apo) A-I mimetic peptides, as D-4F and L-4F, reduce pathological lipid deposits in the bruch‘s membrane (BRM), and in the sub-RPE space. In this study we investigated the effect of D-4F on RPE cell proliferation and oxidative stress-induced[for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Idiopathic intracranial hypertension is a variety of intracranial hypertension that is extremely rare in men. Obesity and hypogonadism are the most important predictive factors. Etiological hypotheses include increased central venous pressure, and various hormonal and metabolic changes commonly found in obese patients. We described the case of an obese man with prostate cancer who showed a consistent bodyweight increase during treatment with taxanes and prednisone. He was hospitalized because of a severe loss of vision as a consequence of idiopathic intracranial hypertension. A complete symptom remission was obtained after 3 weeks of anti-edema therapies (steroids, acetazolamide). Castration-resistant prostate cancer is a risk factor for idiopathic intracranial hypertension. Long-term androgen deprivation therapy, bodyweight increase, and fluid retention during chronic steroid administration and taxane chemotherapy might favor the disease onset. This severe complication has a good outcome, and should be suspected in the presence of symptoms and signs of intracranial hypertension.

Background: Retinal pigment epithelial tears (RIP) are usually preceded by pigment epithelial detachments and may occur spontaneously or under therapy in cases of age-related macula degeneration. The visual function is usually decreased significantly, when the foveal area is involved. Methods: Herein[for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Background: Dye solutions such as indocyanine green (ICG) are used for intraoperative staining of epiretinal membranes and the internal limiting membrane to enhance the visualization and to facilitate their removal. The aim of the presented study was to investigate the effects of ICG on bovine retinal[for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Aim: Evaluation of the effect of Everolimus on the viability, proliferation, and migration of the uveal melanoma cell line 92.1 as well as the expression of several metastatic proteins. Methods: The 92.1 uveal melanoma cells were cultured in RPMI1640 supplemented with 10% serum and treated [for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

We previously determined the presence of circulating melanoma cells (CMCs) in uveal melanoma patients without metastatic disease and correlated the presence with other prognostic risk factors. The aim of this study was to further evaluate CMCs in uveal melanoma patients as diagnostic and prognostic [for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Introduction: Age-related macular degeneration (AMD) is the leading cause of blindness in people over age 55 in the developed world. Loss of retinal pigmented epithelium (RPE) plays a major pathophysiologic role in the disease. Stem cells are currently considered for RPEreplacement. Based on their level[for full text, please go to the a.m. URL], 26. Jahrestagung der Retinologischen Gesellschaft

Einführung: Der Einfluss von photodynamischer Therapie (PDT) mit Verteporfin und Triamcinolonacetonid (TA) Kombinationstherapie auf die Expression von PEDF (pigment epithelium derived factor) und VEGF (vascular endothelial growth factor) bei Patienten mit choroidaler Neovaskularisation (CNV) und[for full text, please go to the a.m. URL], 25. Jahrestagung der Retinologischen Gesellschaft

Hintergrund: Um die Effekte von intraokularem Ranibizumab (Lucentis®) als adjuvante Behandlung bei an Rubeosis iridis (R) bzw. an sekundärem Neovaskularisationsglaukom (NG) erkrankten Patienten prospektiv zu beurteilen. Methoden: 10 Augen mit NG und 10 Augen mit R, welche durch eine proliferative[for full text, please go to the a.m. URL], 24. Jahrestagung der Retinologischen Gesellschaft

Zielsetzung: Evaluation einer Operationsmikroskop integrierten OCT-Kamera zur intraoperativen Diagnostik und Assistenz. Patienten und Methode: Mit der neu entwickelten OCT-Kamera (MOELLER-WEDEL, Wedel, in Kooperation mit OPTOMEDICAL TECHNOLOGIES, Lübeck, Germany), welche in dem Operationsmikroskop[for full text, please go to the a.m. URL], 23. Jahrestagung der Retinologischen Gesellschaft

Hintergrund: In der Übergangszone zur geographischen Atrophie (GA) zeigen sich typische Veränderungen des RPE-Bruchmembran-Komplexes, die mit moderner klinischer Bildgebung (spectral domain OCT, Autofluoreszenz) detektiert werden können. Die Interpretation dieser zellulären Phänomene[for full text, please go to the a.m. URL], 23. Jahrestagung der Retinologischen Gesellschaft

Hintergrund: Kongenitale albinotische Flecken des retinalen Pigmentepithels sind sehr seltene retinale Veränderungen. Sowohl die funktionellen als auch die zugrundeliegenden morphologischen Veränderungen werden in der Literatur kontrovers diskutiert. Methoden: Fallbericht eines 45-jährigen[for full text, please go to the a.m. URL], 22. Jahrestagung der Retinologischen Gesellschaft

Objective: To evaluate the early effects of triamcinolone acetonide (TA) as either monotherapy or adjuvant to verteporfin photodynamic therapy (PDT) on expression of matrix metalloproteinases (MMP) -2, -9 and endostatin in human choroidal neovascularization (CNV) secondary to age related macular degeneration.[for full text, please go to the a.m. URL], 22. Jahrestagung der Retinologischen Gesellschaft