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201. Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens

Author

Steiner, Bernhard, primary, Rosendahl, Jonas, additional, Witt, Heiko, additional, Teich, Niels, additional, Keim, Volker, additional, Schulz, Hans-Ulrich, additional, Pfützer, Roland, additional, Löhr, Matthias, additional, Gress, Thomas M., additional, Nickel, Renate, additional, Landt, Olfert, additional, Koudova, Monika, additional, Macek Jr, Milan, additional, Farre, Antoni, additional, Casals, Teresa, additional, Desax, Marie-Claire, additional, Gallati, Sabina, additional, Gomez-Lira, Macarena, additional, Audrezet, Marie Pierre, additional, Férec, Claude, additional, des Georges, Marie, additional, Claustres, Mireille, additional, and Truninger, Kaspar, additional

Published
2012
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205. StellaTUM: current consensus and discussion on pancreatic stellate cell research

Author

Erkan, Mert, primary, Adler, Guido, additional, Apte, Minoti V, additional, Bachem, Max G, additional, Buchholz, Malte, additional, Detlefsen, Sönke, additional, Esposito, Irene, additional, Friess, Helmut, additional, Gress, Thomas M, additional, Habisch, Hans-Joerg, additional, Hwang, Rosa F, additional, Jaster, Robert, additional, Kleeff, Jörg, additional, Klöppel, Günter, additional, Kordes, Claus, additional, Logsdon, Craig D, additional, Masamune, Atsushi, additional, Michalski, Christoph W, additional, Oh, Junseo, additional, Phillips, Phoebe A, additional, Pinzani, Massimo, additional, Reiser-Erkan, Carolin, additional, Tsukamoto, Hidekazu, additional, and Wilson, Jeremy, additional

Published
2011
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207. Disruption of a Nuclear NFATc2 Protein Stabilization Loop Confers Breast and Pancreatic Cancer Growth Suppression by Zoledronic Acid

Author

Singh, Shiv K., primary, Baumgart, Sandra, additional, Singh, Garima, additional, König, Alexander O., additional, Reutlinger, Kristina, additional, Hofbauer, Lorenz C., additional, Barth, Peter, additional, Gress, Thomas M., additional, Lomberk, Gwen, additional, Urrutia, Raul, additional, Fernandez-Zapico, Martin E., additional, and Ellenrieder, Volker, additional

Published
2011
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209. Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens

Author

Steiner, Bernhard, primary, Rosendahl, Jonas, additional, Witt, Heiko, additional, Teich, Niels, additional, Keim, Volker, additional, Schulz, Hans‐Ulrich, additional, Pfützer, Roland, additional, Lühr, Matthias, additional, Gress, Thomas M., additional, Nickel, Renate, additional, Landt, Olfert, additional, Koudova, Monika, additional, Macek, Milan, additional, Farre, Antoni, additional, Casals, Teresa, additional, Desax, Marie‐Claire, additional, Gallati, Sabina, additional, Gomez‐Lira, Macarena, additional, Audrezet, Marie Pierre, additional, Férec, Claude, additional, des Georges, Marie, additional, Claustres, Mireille, additional, and Truninger, Kaspar, additional

Published
2011
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210. Inflammation, Regeneration, and Transformation in the Pancreas

Author

Giehl, Klaudia, primary, Bachem, Max, additional, Beil, Michael, additional, Böhm, Bernhard O., additional, Ellenrieder, Volker, additional, Fulda, Simone, additional, Gress, Thomas M., additional, Holzmann, Karlheinz, additional, Kestler, Hans A., additional, Kornmann, Marko, additional, Menke, Andre, additional, Möller, Peter, additional, Oswald, Franz, additional, Schmid, Roland M., additional, Schmidt, Volker, additional, Schirmbeck, Reinhold, additional, Seufferlein, Thomas, additional, von Wichert, Götz, additional, Wagner, Martin, additional, Walther, Paul, additional, Wirth, Thomas, additional, and Adler, Guido, additional

Published
2011
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213. Sequential Activation of NFAT and c-Myc Transcription Factors Mediates the TGF-β Switch from a Suppressor to a Promoter of Cancer Cell Proliferation

Author

Singh, Garima, primary, Singh, Shiv K., additional, König, Alexander, additional, Reutlinger, Kristina, additional, Nye, Monica D., additional, Adhikary, Tillman, additional, Eilers, Martin, additional, Gress, Thomas M., additional, Fernandez-Zapico, Martin E., additional, and Ellenrieder, Volker, additional

Published
2010
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214. Complete Analysis of the Human Mesotrypsinogen Gene (PRSS3) in Patients with Chronic Pancreatitis

Author

Rosendahl, Jonas, primary, Teich, Niels, additional, Kovacs, Peter, additional, Szmola, Richard, additional, Blüher, Matthias, additional, Gress, Thomas M., additional, Hoffmeister, Albrecht, additional, Keim, Volker, additional, Löhr, Matthias, additional, Mössner, Joachim, additional, Nickel, Renate, additional, Ockenga, Johann, additional, Pfützer, Roland, additional, Schulz, Hans-Ulrich, additional, Stumvoll, Michael, additional, Wittenburg, Henning, additional, Sahin-Tóth, Miklós, additional, and Witt, Heiko, additional

Published
2010
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216. Mutational Analysis of the Gene Encoding the Zymogen Granule Membrane Glycoprotein 2 (GP2) in Patients With Chronic Pancreatitis

Author

Witt, Heiko, primary, Rosendahl, Jonas, additional, te Morsche, René H.M., additional, Santhosh, Sundaresan, additional, Chacko, Ashok, additional, Schulz, Hans-Ulrich, additional, Landt, Olfert, additional, Teich, Niels, additional, Keim, Volker, additional, Mössner, Joachim, additional, Gress, Thomas M., additional, Ockenga, Johann, additional, Schmidt, Hartmut, additional, Kovacs, Peter, additional, Blüher, Matthias, additional, Stumvoll, Michael, additional, Kage, Andreas, additional, Groneberg, David Alexander, additional, Jansen, Jan B.M.J., additional, Nickel, Renate, additional, and Drenth, Joost P.H., additional

Published
2010
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217. NFAT-Induced Histone Acetylation Relay Switch Promotes c-Myc-Dependent Growth in Pancreatic Cancer Cells

Author

Köenig, Alexander, primary, Linhart, Thomas, additional, Schlengemann, Katrin, additional, Reutlinger, Kristina, additional, Wegele, Jessica, additional, Adler, Guido, additional, Singh, Garima, additional, Hofmann, Leonie, additional, Kunsch, Steffen, additional, Büch, Thomas, additional, Schäfer, Eva, additional, Gress, Thomas M., additional, Fernandez–Zapico, Martin E., additional, and Ellenrieder, Volker, additional

Published
2010
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225. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

Author

Rosendahl, Jonas, primary, Witt, Heiko, additional, Szmola, Richárd, additional, Bhatia, Eesh, additional, Ózsvári, Béla, additional, Landt, Olfert, additional, Schulz, Hans-Ulrich, additional, Gress, Thomas M, additional, Pfützer, Roland, additional, Löhr, Matthias, additional, Kovacs, Peter, additional, Blüher, Matthias, additional, Stumvoll, Michael, additional, Choudhuri, Gourdas, additional, Hegyi, Péter, additional, te Morsche, René HM, additional, Drenth, Joost PH, additional, Truninger, Kaspar, additional, Macek, Milan, additional, Puhl, Gero, additional, Witt, Ulrike, additional, Schmidt, Hartmut, additional, Büning, Carsten, additional, Ockenga, Johann, additional, Kage, Andreas, additional, Groneberg, David Alexander, additional, Nickel, Renate, additional, Berg, Thomas, additional, Wiedenmann, Bertram, additional, Bödeker, Hans, additional, Keim, Volker, additional, Mössner, Joachim, additional, Teich, Niels, additional, and Sahin-Tóth, Miklós, additional

Published
2007
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227. Tumor suppressor p16INK4a − modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells

Author

André, Sabine, primary, Sanchez-Ruderisch, Hugo, additional, Nakagawa, Hiroaki, additional, Buchholz, Malte, additional, Kopitz, Jürgen, additional, Forberich, Pia, additional, Kemmner, Wolfgang, additional, Böck, Corina, additional, Deguchi, Kisaburo, additional, Detjen, Katharia M., additional, Wiedenmann, Bertram, additional, von Knebel Doeberitz, Magnus, additional, Gress, Thomas M., additional, Nishimura, Shin-Ichiro, additional, Rosewicz, Stefan, additional, and Gabius, Hans-Joachim, additional

Published
2007
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230. Stromal biology and therapy in pancreatic cancer: a changing paradigm.

Author

Neesse, Albrecht, Algül, Hana, Tuveson, David A., and Gress, Thomas M.

Subjects
PANCREATIC cancer treatment, ADENOCARCINOMA, CANCER treatment, CANCER chemotherapy, PALLIATIVE treatment, CANCER patients, PANCREATIC cancer, PROGNOSIS
Abstract

Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid tumours and poses an unsolved problem in cancer medicine. Despite the recent success of two combination chemotherapies for palliative patients, the modest survival benefits are often traded against significant side effects and a compromised quality of life. Although the molecular events underlying the initiation and progression of PDA have been intensively studied and are increasingly understood, the reasons for the poor therapeutic response are hardly apprehended. One leading hypothesis over the last few years has been that the pronounced tumour microenvironment in PDA not only promotes carcinogenesis and tumour progression but also mediates therapeutic resistance. To this end, targeting of various stromal components and pathways was considered a promising strategy to biochemically and biophysically enhance therapeutic response. However, none of the efforts have yet led to efficacious and approved therapies in patients. Additionally, recent data have shown that tumour-associated fibroblasts may restrain rather than promote tumour growth, reinforcing the need to critically revisit the complexity and complicity of the tumour-stroma with translational implications for future therapy and clinical trial design. [ABSTRACT FROM AUTHOR]

Published
2015
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231. Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer

Author

Treiber, Matthias, primary, Schulz, Hans-Ulrich, additional, Landt, Olfert, additional, Drenth, Joost PH, additional, Castellani, Carlo, additional, Real, Francisco X., additional, Akar, Nejat, additional, Ammann, Rudolf W., additional, Bargetzi, Mario, additional, Bhatia, Eesh, additional, Demaine, Andrew Glenn, additional, Battagia, Cinzia, additional, Kingsnorth, Andrew, additional, O’Reilly, Derek, additional, Truninger, Kaspar, additional, Koudova, Monika, additional, Spicak, Julius, additional, Cerny, Milos, additional, Menzel, Hans-Jürgen, additional, Moral, Pedro, additional, Pignatti, Pier Franco, additional, Romanelli, Maria Grazia, additional, Rickards, Olga, additional, De Stefano, Gian Franco, additional, Zarnescu, Narcis Octavian, additional, Choudhuri, Gourdas, additional, Sikora, Sadiq S., additional, Jansen, Jan B. M. J., additional, Weiss, Frank Ulrich, additional, Pietschmann, Matthias, additional, Teich, Niels, additional, Gress, Thomas M., additional, Ockenga, Johann, additional, Schmidt, Hartmut, additional, Kage, Andreas, additional, Halangk, Juliane, additional, Rosendahl, Jonas, additional, Groneberg, David Alexander, additional, Nickel, Renate, additional, and Witt, Heiko, additional

Published
2006
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233. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Author

Witt, Heiko, primary, Sahin-Tóth, Miklós, additional, Landt, Olfert, additional, Chen, Jian-Min, additional, Kähne, Thilo, additional, Drenth, Joost PH, additional, Kukor, Zoltán, additional, Szepessy, Edit, additional, Halangk, Walter, additional, Dahm, Stefan, additional, Rohde, Klaus, additional, Schulz, Hans-Ulrich, additional, Le Maréchal, Cédric, additional, Akar, Nejat, additional, Ammann, Rudolf W, additional, Truninger, Kaspar, additional, Bargetzi, Mario, additional, Bhatia, Eesh, additional, Castellani, Carlo, additional, Cavestro, Giulia Martina, additional, Cerny, Milos, additional, Destro-Bisol, Giovanni, additional, Spedini, Gabriella, additional, Eiberg, Hans, additional, Jansen, Jan B M J, additional, Koudova, Monika, additional, Rausova, Eva, additional, Macek, Milan, additional, Malats, Núria, additional, Real, Francisco X, additional, Menzel, Hans-Jürgen, additional, Moral, Pedro, additional, Galavotti, Roberta, additional, Pignatti, Pier Franco, additional, Rickards, Olga, additional, Spicak, Julius, additional, Zarnescu, Narcis Octavian, additional, Böck, Wolfgang, additional, Gress, Thomas M, additional, Friess, Helmut, additional, Ockenga, Johann, additional, Schmidt, Hartmut, additional, Pfützer, Roland, additional, Löhr, Matthias, additional, Simon, Peter, additional, Weiss, Frank Ulrich, additional, Lerch, Markus M, additional, Teich, Niels, additional, Keim, Volker, additional, Berg, Thomas, additional, Wiedenmann, Bertram, additional, Luck, Werner, additional, Groneberg, David Alexander, additional, Becker, Michael, additional, Keil, Thomas, additional, Kage, Andreas, additional, Bernardova, Jana, additional, Braun, Markus, additional, Güldner, Claudia, additional, Halangk, Juliane, additional, Rosendahl, Jonas, additional, Witt, Ulrike, additional, Treiber, Matthias, additional, Nickel, Renate, additional, and Férec, Claude, additional

Published
2006
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236. Specialized DNA Arrays for the Differentiation of Pancreatic Tumors

Author

Buchholz, Malte, primary, Kestler, Hans A., additional, Bauer, Andrea, additional, Böck, Wolfgang, additional, Rau, Bettina, additional, Leder, Gerhard, additional, Kratzer, Wolfgang, additional, Bommer, Martin, additional, Scarpa, Aldo, additional, Schilling, Martin K., additional, Adler, Guido, additional, Hoheisel, Jörg D., additional, and Gress, Thomas M., additional

Published
2005
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239. Prevalence of familial pancreatic cancer in Germany

Author

Bartsch, Detlef K., primary, Kress, Ralf, additional, Sina-Frey, Mercedes, additional, Grützmann, Robert, additional, Gerdes, Berthold, additional, Pilarsky, Christian, additional, Heise, Joachim W., additional, Schulte, Klaus-Martin, additional, Colombo-Benkmann, Mario, additional, Schleicher, Cristina, additional, Witzigmann, Helmut, additional, Pridöhl, Olaf, additional, Ghadimi, Michael B., additional, Horstmann, Olaf, additional, von Bernstorff, Wolfgang, additional, Jochimsen, Lisa, additional, Schmidt, Jan, additional, Eisold, Sven, additional, Estévéz-Schwarz, Lope, additional, Hahn, Stephan A., additional, Schulmann, Karsten, additional, Böck, Wolfgang, additional, Gress, Thomas M., additional, Zügel, Nikolaus, additional, Breitschaft, Karl, additional, Prenzel, Klaus, additional, Messmann, Helmut, additional, Endlicher, Esther, additional, Schneider, Margarete, additional, Ziegler, Andreas, additional, Schmiegel, Wolff, additional, Schäfer, Helmut, additional, Rothmund, Matthias, additional, and Rieder, Harald, additional

Published
2004
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241. Molecular Pathology of Ampullary, Intra-Pancreatic Bile Duct and Duodenal Cancers.

Author

Michl, Patrick, Neesse, Albrecht, and Gress, Thomas M.

Abstract

Periampullary cancers include carcinomas of the pancreatic head, ampullary cancers at the papilla of Vater, duodenal cancers and distal bile duct cancers. Due to their anatomical location close to the orifice of the biliary tract into the duodenum, they often present with similar symptoms. Likewise, curative treatment approaches such as Whipple procedure or its variants, are applied similarly for most periampullary cancers. However, striking differences in survival are consistently being observed between the different periampullary tumor types, and histological classification is sometimes difficult due to overlapping histopathological phenotypes. During recent years, increasing effort has been made to elucidate the molecular alterations underlying the observed histopathological and prognostic differences among periampullary tumors. This chapter concentrates on the molecular pathology of the three non-pancreatic carcinoma types located in the periampullary region: Ampullary, duodenal and distal bile duct cancer. Immunohistochemically, ampullary carcinomas are subclassified into an intestinal-type and a pancreaticobiliary-type. Intestinal-type ampullary cancers closely resemble duodenal cancers and both are molecularly related to other bowel cancers such as colorectal cancer. In contrast, distal bile duct carcinomas and ampullary carcinomas of the pancreatico-biliary type are more related to ductal pancreatic cancer. However, the prognosis varies considerably, with survival rates being greatest for ampullary and duodenal cancers and least for pancreatic cancer. Periampullary cancers may be associated with familial cancer syndromes such as familial adenomatous polyposis (FAP) or hereditary non-polypous colon cancer (HNPCC). In these cases, the underlying molecular alterations have been elucidated. In contrast, data on the molecular patterns characterizing sporadic periampullary non-pancreatic cancers are still fragmentary and further studies are required to better understand their genetic, transcriptional and epigenetic characteristics. [ABSTRACT FROM AUTHOR]

Published
2010
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242. Principles and Applications of Microarray Gene Expression in Pancreatic Cancer.

Author

Buchholz, Malte and Gress, Thomas M.

Abstract

Like most other malignancies, pancreatic cancer is a polygenic disease arising from the accumulation of multiple genetic and epigenetic defects in the affected cells. DNA arrays offer the possibility to monitor the expression levels of thousands of mRNA transcripts simultaneously in a single assay, making them ideal tools to study the complex network of transcriptional changes that are associated with the malignant transformation of normal cells. Expression profiling analyses are rapidly expanding our knowledge of pancreatic cancer biology, laying the basis for the development of more sophisticated diagnostic procedures and more effective treatment modalities. Moreover, microarrays can directly be employed as highly sophisticated diagnostic tools in the clinic, enabling the extraction of much more detailed and differentiated diagnostic information from biopsy samples than single molecular markers or conventional diagnostic procedures can provide. [ABSTRACT FROM AUTHOR]

Published
2010
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244. A Perceptually Optimized Scheme for Visualizing Gene Expression Ratios with Confidence Values.

Author

André, Elisabeth, Dybkjær, Laila, Minker, Wolfgang, Neumann, Heiko, Weber, Michael, Kestler, Hans A., Müller, Andre, Buchholz, Malte, Gress, Thomas M, and Palm, Günther

Abstract

Gene expression data studies are often concerned with comparing experimental versus control conditions. Ratios of gene expression values, fold changes, are therefore commonly used as biologically meaningful markers. Visual representations are inevitable for the explorative analysis of data. Fold changes alone are no reliable markers, since low signal intensities may lead to unreliable ratios and should therefore be visually marked less important than the more trustworthy ratios of larger expression values. Methods: We propose a new visualization scheme showing ratios and their confidence together in one single diagram, enabling a more precise explorative assessment of gene expression data. Basis of the visualization scheme are near-uniform perceptible color scales improving the readability of the commonly used red-green color scale. A sub-sampling algorithm for optimizing color scales is presented. Instead of difficult to read bivariate color maps encoding two variables into a single color we propose the use of colored patches (rectangles) of different sizes representing the absolute values, while representing ratios by a univariate color map. Different pre-processing steps for visual bandwidth limitation and reliability value estimation are proposed. Results and Conlusions: The proposed bivariate visualization scheme shows a clear perceptible order in ratio and reliability values leading to better and clearer interpretable diagrams. The proposed color scales were specifically adapted to human visual perception. Psychophysical optimized color scales are superior to traditional sRGB red-green maps. This leads to an improved explorative assessment of gene expression data. [ABSTRACT FROM AUTHOR]

Published
2006
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245. KHDomain

Author

Mueller, Friederike, primary, Lacher, Ulrike, additional, and Gress, Thomas M., additional

Published
2002
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249. Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis

Author

Wallrapp, Christine, primary, Hähnel, Susanne, additional, Boeck, Wolfgang, additional, Soder, Anja, additional, Mincheva, Antoaneta, additional, Lichter, Peter, additional, Leder, Gerhard, additional, Gansauge, Frank, additional, Sorio, Claudio, additional, Scarpa, Aldo, additional, and Gress, Thomas M., additional

Published
2001
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