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Nyctanthes arbor-tristis L. contains various phytochemicals with tremendous potential to fight against different infections. However, the effect of these phytochemicals on Mycobacterium tuberculosis is yet unknown. Treatment of multi-drug resistance (MDR) and extensively drug-resistant (XDR) strains of the tuberculosis bacterium are still challenging. Therefore, there is an urgent need to overcome this problem. The present review focuses on the potential action of the hypolipidemic phytochemicals obtained from N. arbor-tristis on the growth and survival of M. tuberculosis in the human host. The extracts from different parts of this plant are hypolipidemic by various established mechanisms. Phytochemicals like iridoids and flavonoids from plant origin exhibit a high capacity to regulate cholesterol and fatty acid biosynthesis in vivo. The hypolipidemic properties of N. arbor-tristis-derived extracts are probably due to the presence of phytochemicals such as iridoids, flavonoids, etc. It may regulate fatty acid biosynthesis in M. tuberculosis by targeting bacterial fatty acid synthase enzyme. Additionally, these phytochemicals also inhibit cholesterol biosynthesis in the host by interrupting the function of HMG-CoA reductase. M. tuberculosis is an intracellular pathogen. It is also established fact as on date that entry of tuberculosis bacterium in the macrophage is macrophage membrane cholesterol-dependent. Host cholesterol is also otherwise necessary by multiple mechanisms for the pathogenesis of tuberculosis. Based on the above facts, we believe that N. arbor-tristis derived phytochemicals can act both on the tuberculosis bacterium and on the host for prevention and cure of tuberculosis. [ABSTRACT FROM AUTHOR]

Key features of biological activity can often be captured by transitions between a finite number of semi-stable states that correspond to behaviors or decisions. We present here a broad class of dynamical systems that are ideal for modeling such activity. The models we propose are chaotic heteroclinic networks with nontrivial intersections of stable and unstable manifolds. Due to the sensitive dependence on initial conditions, transitions between states are seemingly random. Dwell times, exit distributions, and other transition statistics can be built into the model through geometric design and can be controlled by tunable parameters. To test our model's ability to simulate realistic biological phenomena, we turned to one of the most studied organisms, C. elegans, well known for its limited behavioral states. We reconstructed experimental data from two laboratories, demonstrating the model's ability to quantitatively reproduce dwell times and transition statistics under a variety of conditions. Stochastic switching between dominant states in complex dynamical systems has been extensively studied and is often modeled as Markov chains. As an alternative, we propose here a new paradigm, namely, chaotic heteroclinic networks generated by deterministic rules (without the necessity for noise). Chaotic heteroclinic networks can be used to model systems with arbitrary architecture and size without a commensurate increase in phase dimension. They are highly flexible and able to capture a wide range of transition characteristics that can be adjusted through control parameters. [ABSTRACT FROM AUTHOR]

Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with antioxidant, anti-inflammatory, and anti-apoptotic effects. In this study, the HO-1 gene from Litopenaeus vannamei (Lv-HO-1) was identified. The open reading frame of Lv-HO-1 is 747 bp, encoding a peptide of 248 amino acids as well as a conserved HemO structural domain. Lv-HO-1 is 70–90% homological to crustaceans and about 50% homological to arthropods. The transcript levels of Lv-HO-1 were highest in the hepatopancreas and lower in other tissues. Knockdown of Lv-HO-1 led to structural destruction of the hepatopancreas. After ammonia exposure, Lv-HO-1 was significantly induced. Knockdown of Lv-HO-1 during ammonia exposure resulted in a significant decrease in antioxidant capacity and cellular autophagy levels compared to the control and increased apoptosis. The transcriptional levels of SOD and GSH-Px were considerably reduced (p < 0.05), as were the transcriptional levels of Atg3, Atg4, Atg5, and Atg10. The results indicated that Lv-HO-1 from L. vannamei can be induced by oxidative stress and may have important roles in regulating the host antioxidant system, reducing cell apoptosis. [ABSTRACT FROM AUTHOR]

The article discusses the author's comments on Ronald W. Greene's essay "Another Materialist Rhetoric" which provides a complex understanding of what a materialist rhetoric might mean and what it might do. Topics discussed include Greene's definition of materialism and rhetoric encompassing and surrounding previous definitions theoretically and critically and his movement to explore the role and function of the historical YMCA film for understanding the utility of his notion.

The feasibility of achieving high performance Li metal batteries, with the associated benefits of high energy density, relies on the development of safe and stable electrolytes suitable for use with the highly reactive Li metal. The use of solid electrolytes can improve safety, decrease the evolution of Li dendrites, and increase the cycle life of a battery. Zwitterions (ZIs) are a unique class of material in which the cationic and anionic moieties are covalently bound, and these have previously been used as additives in electrolytes to improve ion transport. We recently reported a novel class of material, zwitterionic plastic crystals, that have intrinsic molecular disorder and offer a promising alternative to traditional organic ionic plastic crystal (OIPC)-based electrolytes. Here we report an investigation into the use of zwitterionic plastic crystals as matrix electrolytes by the incorporation of different types and concentrations of Li salts, namely lithium bis(fluorosulfonyl)imide (LiFSI) or lithium tetrafluoroborate (LiBF4), and the influence of lithium salt species and concentration on the thermal behaviour and ion dynamics. To understand the effect of ion tethering on the physicochemical properties of the ZI electrolytes we compared their thermal behaviour and ionic conductivity with the analogous OIPC electrolytes, namely [C2mpyr][BF4]. The low and high salt concentrations of ZI/LiBF4 and ZI/LiFSI mixtures form solid-state electrolytes, and the middle concentrations (30–80 mol%) yield liquids at room temperature. The ion dynamics and diffusion were studied by NMR spectroscopy and pulsed-field gradient NMR. The ZI/LiFSI mixtures exhibited lower glass transition temperatures and higher ionic conductivity and higher Li ion mobility than the ZI/LiBF4 mixtures. Finally, electrochemical analysis of the high LiFSI content ZI electrolyte demonstrated a high Li transference number and stable stripping/plating of Li in Li symmetrical and full cells. The combination of high ionic conductivity, high Li ion transference number and stable lithium cycling make zwitterion-based electrolytes promising candidates for lithium metal battery applications. [ABSTRACT FROM AUTHOR]

The article discusses the PEACE with COVID program aimed at encouraging vaccination against COVID-19 by Black and Latinx substance-using men who have sex with men (BLSUM) in the U.S. Other topics include the disproportionate COVID-19-related hospitalizations and deaths among African American and Latinx persons, the approval by the Federal Drug Administration (FDA) of several COVID-19 vaccines, and the steps in developing the program like partnership, education and activation.

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Plasma shaping may have a stronger effect on global turbulence in tight-aspect-ratio tokamaks than in conventional-aspect-ratio tokamaks due to the higher toroidicity and more acute poloidal asymmetry in the magnetic field. In addition, previous local gyrokinetic studies have shown that it is necessary to include parallel magnetic field perturbations in order to accurately compute growth rates of electromagnetic modes in tight-aspect-ratio tokamaks. In this work, the effects of elongation and triangularity on global, ion-scale, linear electromagnetic modes are studied at National Spherical Torus Experiment (NSTX) aspect ratio and high plasma β using the global gyrokinetic particle-in-cell code XGC. The effects of compressional magnetic perturbations are approximated via a well-known modification to the particle drifts that was developed for flux-tube simulations [Joiner et al., Phys. Plasmas 17, 072104 (2010)], without proof of its validity in a global simulation, with the gyrokinetic codes GENE and GEM being used for local verification and global cross-verification. Magnetic equilibria are re-constructed for each distinct plasma profile that is used. Coulomb collision effects are not considered. Within the limitations imposed by the present study, it is found that linear growth rates of electromagnetic modes (collisionless microtearing modes and kinetic ballooning modes) are significantly reduced in a high-elongation and high-triangularity NSTX-like geometry compared to a circular NSTX-like geometry. For example, growth rates of kinetic ballooning modes at high-β are reduced to the level of that of collisionless trapped electron modes. [ABSTRACT FROM AUTHOR]

Copyright of Revista del CLAD Reforma y Democracia is the property of Centro Latinoamericano de Administracion para el Desarrollo (CLAD) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The performance of next generation solid-state lithium metal batteries (LMBs) is intimately related to the ionic-electronic interconnection within the cathode material. In batteries containing liquid electrolytes, the soaking of the electrolyte and the addition of carbon provide sufficient ionic and electronic conductivity through the cathode. However, in solid-state systems, cathodes are completely dry, and thus, they lack mobile Li ions and good electronic interconnection. Organic mixed ionic-electronic conductors (OMIECs) are promising binders to provide that interconnection through a compact carbon-free cathode. However, most of the OMIECs have been developed based on solvent swelling of conducting polymers or combining with ionic liquids as composites. These options are not the most adequate ones for LMBs due to liquid-related issues such as leakage. Here, a novel approach towards all-solid-state OMIECs is presented by combining PEDOT:PSS and different organic ionic plastic crystals (OIPCs): C2mpyrFSI and C2mpyrTFSI, obtaining a synergistic effect with higher ionic and electronic conductivities than those of the neat materials (σelectronic of 580 S cm−1 and σionic of 3.7 10−5 S cm−1 at 70 °C). These outstanding values for all-solid state OMIECs resulted from highly ordered conducting pathways as demonstrated by XRD and AFM. The optimum composition with respect to electronic and ionic conductivity (80/20 PEDOT:PSS/C2mpyFSI) was subsequently tested, for the first time, as a binder in a LiFePO4 cathode formulation in a carbon-free solid-state battery. The solid-state Li‖LiFePO4 cell with the OMIEC binder showed an enhanced discharge capacity (157 mA h g−1 at C/10) and improved rate capability, in comparison to a solid-state cathode formulation using an ionic conducting polymeric binder and carbon additive. A specific capacity of 145.5 mA h g−1 at C/2 rate was achieved with an excellent capacity retention of 99.7% (145.2 mA h g−1) after 500 cycles. [ABSTRACT FROM AUTHOR]

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Voluntary counselling and testing (VCT) is key in HIV prevention. Young people aged 15–24 years carry a significant burden of new infections globally, but VCT uptake is low in this population. The study assessed university freshmen's willingness to test for HIV now, among others, in a cross-sectional study as university campuses are places of risky sexual behaviour. Structured questionnaires were used to collect data on age, sex, marital status, HIV/AIDS knowledge, previous history of testing, willingness to test now, and others. Summary statistics were reported while chi-square and logistic regression methods were used to assess the association between dependent and independent variables with p-values < 0.05 held significant. About 90% (374/412) of respondents had good HIV/AIDS knowledge based on criteria defined by the study, but only 23.3% (96/412) had ever tested and 66.3% (266/401) were willing to test now for HIV. Respondents' sex, previous sexual intercourse, and whether respondents' educational support was from parents or non-parents influenced willingness to test for HIV now. The study highlights what appears to be personal beliefs that can potentially hinder HIV testing and control efforts. Relevant stakeholders must address these gaps to improve testing. Further qualitative investigation will improve understanding of the dynamics informing willingness to test for HIV among young people generally. [ABSTRACT FROM AUTHOR]

Copyright of Revista Interamericana de Psicología is the property of Sociedad Interamericana de Psicologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Also named as social networking, entrepreneurial social networks discuss relations with other organizations, business groups and people who help entrepreneurs to create enterprises. The general objective of this study is to analyze how social entrepreneurs use their social networks or relationships to get resources and organizational legitimacy during the conception phase of their business. This paper particularly intends to identify social ties as defined by Granovetter (1973), to point out the resources mobilized through social networks according to the classification proposed by Brush, Greene and Hart (2001), and to verify social organizations legitimacy criteria based on Atack's (1999) typology. This study has a qualitative approach and is exploratory and descriptive in nature. The research strategy adopted was of multiple case study. Evidences were collected through semi-structured interviews with three social entrepreneurs. The dialogues were recorded and subsequently transcribed. The interview content was analyzed adopting the content analysis technique. After analyzing the cases, it was observed in the entrepreneurs' social networks both weak and strong ties. The latter were basically family, friends and professional colleagues. With regard to weak ties, public and private companies and donors/individual collaborators were cited. The strong ties, in particular, encouraged virtually all types of resources needed for the conception of the social organizations analyzed. Weak ties, on the other hand, promoted a good portion of the physical resources required for the analyzed organizations. It was also possible to observe that social networks contributed to legitimize the social organizations analyzed. It was verified how participative they were with respect to promotion of formal procedural legitimacy. However, entrepreneurs still could have enhanced this source of resources, taking better advantage within the substantive-purposeful legitimacy, fostering the promotion of mechanisms to motivate and attract volunteers, developing criteria to measure the effectiveness of promoted activities or taking advantage of the intellectual capital of their networks by encouraging collective decision-making. [ABSTRACT FROM AUTHOR]

Se argumenta que, en barrios periurbanos de producción Estatal, las propiedades espaciales del entorno construido y la forma física de lo edificado, no son suficientes para comprender la complejidad de la concentración de delitos y la formación de barrios seguros. Cuando se trata de barrios de producción estatal localizados en áreas desprovistas de servicios y equipamientos, la escala de análisis del espacio y la formación de centralidad cobra vital importancia. En términos de seguridad, la investigación sobre el trazado de la trama urbana y espacios públicos en áreas residenciales son esporádicos e inconcluyentes (Hillier & Sahbaz, 2008). En este mismo ámbito se ha priorizado la idea de apropiación defensiva del espacio, por sobre la necesidad de construir barrios seguros (Greene y Mora, 2018), dando menor atención al rol del espacio público y privado, en términos de seguridad y ocurrencia de delitos. Ante esta necesidad, esta investigación tiene como objetivo identificar y comprender las propiedades espaciales del entorno construido que intervienen en la formación de barrios seguros, problematizando la ocurrencia de delitos en el espacio público y privado, de esta forma dar luces sobre el potencial del entorno construido para favorecer -o no- la formación de barrios seguros. La investigación aborda dos barrios localizados en el periurbano de la comuna de San Pedro de la Paz, región del Bío-Bío, Chile: Boca Sur Nuevo y San Pedro de la Costa, sectores contiguos pero originados por el Estado en períodos históricos diferentes. El estudio utiliza una metodología cuantitativa, por un lado, para el análisis espacial, se implementa el enfoque de Sintaxis Espacial desarrollado por Hillier y Hanson (1984). La sintaxis espacial se basa en la teoría de grafos de la matemática discreta para el cálculo de las relaciones espaciales configurativas entre las calles de la ciudad (Yamu, 2021). Este enfoque se complementa con la metodología de Solá Morales (1997) a partir de los preceptos de urbanización, parcelación y edificación. Así, el espacio se observa como un aspecto intrínseco de las actividades que realizan las personas, refiriéndose no solo a las cualidades de los espacios individuales, sino también a las interrelaciones entre los espacios que componen la disposición espacial y el modo en que las personas utilizan y se mueven por las ciudades. Por otro lado, se realiza un análisis socioespacial cuantitativo de la concentración de delitos en el espacio, los datos son extraídos del Sistema Estadístico Delictual (SIED) en su versión de datos territoriales para el año 2019. En el análisis se consideraron delitos de mayor connotación social (DMCS), referidos a aquellos “delitos de carácter violento y que afectan la propiedad, la vida y bienes de las personas, generando con ello un impacto público” (AMUCH, 2018). Los datos delictuales fueron complementados con variables espaciales del caso de estudio. Los resultados muestran que el enfoque de Sintaxis Espacial. junto al enfoque morfológico de Solá Morales, permiten identificar las propiedades espaciales que son decisivas a la hora de mejorar entornos urbanos a nivel barrial y a nivel comunal en términos de barrios seguros, profundizando los modos de urbanización de los Estados Neoliberales que influyen en la percepción de la seguridad.

This article provides a brief overview and perspective on the radiation response of nanoscale metal–oxide–semiconductor (MOS) devices. MOS total-ionizing-dose (TID) response is affected strongly by size scaling and the migration from planar to three-dimensional architectures. Radiation-induced charge trapping in isolation oxides and/or charge transport from surrounding materials are critical to the TID response of nanoscale MOS devices. As transistor dimensions and operating voltages have decreased, single-event effects due to cosmic rays and high-energy protons in space and neutrons in terrestrial environments have become increasingly significant to the radiation response of MOS devices. However, nanoscale MOS transistors are essentially immune to ion-induced gate rupture at normal operating voltages. Single-particle interactions will become even more important for future, ultimately scaled MOS devices used in classical and quantum computing applications. [ABSTRACT FROM AUTHOR]

PbTe and PbSe are among the most promising thermoelectric materials used in the mid‐temperature (400–900 K) power generation range. In these materials the efficiency increase in thermoelectric performance is critically related to the lowering of lattice thermal conductivity (κL), without compromising the electronic power factor. By means of state‐of‐the‐art equilibrium molecular dynamics (EMD), we investigate heat transport in several nanostructured PbTe/PbSe models as a function of material morphology. Layered composites show a reduction of the average κL of about 35 % with respect to the bulk. The insertion of PbSe nanoparticles into a PbTe matrix, or viceversa PbTe into PbSe reduces κL by up to 45 % while in more anisotropic nanocomposites the reduction exceeds PbSe/PbTe alloys. Layered composites show the lowest lattice thermal conductivity in the direction of layer stacking, for which an optimal thickness is identified. Along this line we provide a full account of the impact of alloying and (sub)nanostructuring on heat transport for this important class of materials. Particularly anisotropic nano‐dot morphologies and layered (sub)nanocomposites emerge as a paradigm for outstanding thermoelectric materials. [ABSTRACT FROM AUTHOR]

Hexamethylguanidinium bis(fluorosulfonyl)imide ([HMG][FSI]) has recently been shown to be a promising solid state organic ionic plastic crystal with potential application in advanced alkali metal batteries. This study provides a detailed exploration of the structural and dynamic behavior of [HMG][FSI] mixtures with the sodium salt NaFSI across the whole composition range from 0 to 100 mol%. All mixtures are solids at room temperature. A combination of differential scanning calorimetry (DSC), synchrotron X-ray diffraction (SXRD) and multinuclear solid state NMR spectroscopy is employed to identify a partial phase diagram. The 25 mol% NaFSI/75 mol% [HMG][FSI] composition presents as the eutectic composition with the eutectic transition temperature at 44 °C. Both DSC and SXRD strongly support the formation of a new compound near 50 mol% NaFSI. Interestingly, the 53 mol% NaFSI [HMG][FSI] composition was consistently found to display features of a pure compound whereas the 50 mol% materials always showed a second phase. Many of the compositions examined showed unusual metastable behaviour. Moreover, the ion dynamics as determined by NMR, indicate that the Na+ and FSI− anions are signifcantly more mobile than the HMG cation in the liquid state (including the metastable state) for these materials. [ABSTRACT FROM AUTHOR]

Copyright of Foro Internacional is the property of El Colegio de Mexico AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

All‐solid‐state batteries (ASSBs) using organic ionic plastic crystals (OIPCs) are promising candidates to overcome the inherent safety issues of lithium‐ion batteries (LIBs). Although OIPCs have excellent process applicability in the roll‐to‐roll electrode fabrication process, their application as solid electrolytes incorporated in composite electrodes has yet to be demonstrated in detail. Herein, we denote the positive effect of the N‐ethyl‐N‐methylpyrrolidinium bis(fluorosulfonyl)imide ([C2mpyr][FSI]) incorporated within a composite graphite anode on the charge rate capability and cycle life. The highest charge capacity ratio (the charge capacity at 2C vs. that measured at 0.1C) was measured for the composite anode with an OIPC composite ratio of 50 wt % (89.5 %, 295.7 mAh/g at 2C charge), almost the same as that of the graphite anode with a liquid electrolyte (85.7 %, 295.9 mAh/g at 2C charge). More favorable lithium‐ion conduction pathways were resolved for the anode with a higher OIPC composite ratio, whereas an excessive amount of OIPC reduced the long‐term cyclability. The most stable discharge capacity retention was obtained for 30 wt % OIPC composite (257.4 mAh/g at the 100th discharge), which showed no signs of discharge capacity fading within 100 cycles. The lithiation/delithiation process of the solid‐state graphite‐[C2mpyr][FSI] composite anode was evaluated to be stable and reversible. In addition, the incorporated OIPC composite enhanced the electrolyte/electrode and electrode/current collector contacts. This work highlights multiple advantageous functions of the OIPC in a composite graphite anode, which will broaden our horizons for the use of OIPC composites in ASSBs. [ABSTRACT FROM AUTHOR]

RF performance of stacked Si nanosheet/ nanowire nFETs considering 6/10-lateral-stack 4-finger transistor array is studied and optimized by validated TCAD simulation. Compared with nFinFETs, stacked Si nanosheets/nanowires can have $2.0/ 2.2\times $ cut-off frequency (435/480 vs 215 GHz) and 1.6/ $2.3\times $ maximum oscillation frequency (405/575 vs 251 GHz) with an optimized equivalent oxide thickness of 0.8nm, a gate length of 18nm, and a floor number of 4/6, using the double-sided gate contact array layout. Because of the small channel cross section of nanowires and the lower carrier density at central nanosheets than edges, stacked nanowires can achieve better RF performance than stacked nanosheets. As the lateral stack number increases to enhance the output power, the contact over active-gate layout can maintain both the high cut-off frequency and the high maximum oscillation frequency of stacked nanosheets and stacked nanowires. [ABSTRACT FROM AUTHOR]

With the development of device miniaturization, traditional Si‐based field effect transistors (FETs) are approaching their scaling limits. It is necessary to find more alternative materials to improve the performance of FETs. 2D semiconductors attract great attention for channel material due to their atomic‐scale smoothness and dangling‐bond‐free surface, and the gate electrostatic properties and charge carrier mobility are better than traditional 3D Si‐based semiconductor. In this paper, using density functional theory combined with nonequilibrium Green's function formalism, the electronic properties and device performance of sub‐5 nm monolayer SiMe‐graphene n‐type field‐effect transistors are evaluated. Remarkably, the on‐state current value of the FET can reach 3070 µA µm−1, which greatly surpasses most of reported FETs based on other 2D semiconductors. In addition, the on‐state current, power dissipation, and delay time of the SiMe‐graphene FETs satisfy the high‐performance requirements of the 2020 International Roadmap for Device and Systems under different supply voltages, which indicates that the FETs can work at different operating frequencies and power consumption. Moreover, via controlling electrode doping concentration, the channel length can be reduced to 4 nm. In total, the SiMe‐graphene is a favorable channel material for future FETs devices. [ABSTRACT FROM AUTHOR]

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Resistance to second-generation androgen receptor (AR) antagonists such as enzalutamide is an inevitable consequence in patients with castration-resistant prostate cancer (CRPC). There are no effective therapeutic options for this recurrent disease. The expression of truncated AR variant 7 (AR-V7) has been suggested to be one mechanism of resistance; however, its low frequency in patients with CRPC does not explain the almost universal acquisition of resistance. We noted that the ability of AR to translocate to nucleus in an enzalutamide-rich environment opens up the possibility of a posttranslational modification in AR that is refractory to enzalutamide binding. Chemical proteomics in enzalutamide-resistant CRPC cells revealed acetylation at Lys609 in the zinc finger DNA binding domain of AR (acK609-AR) that not only allowed AR translocation but also galvanized a distinct global transcription program, conferring enzalutamide insensitivity. Mechanistically, acK609-AR was recruited to the AR and ACK1/TNK2 enhancers, up-regulating their transcription. ACK1 kinase–mediated AR Y267 phosphorylation was a prerequisite for AR K609 acetylation, which spawned positive feedback loops at both the transcriptional and posttranslational level that regenerated and sustained high AR and ACK1 expression. Consistent with these findings, oral and subcutaneous treatment with ACK1 small-molecule inhibitor, (R)-9b, not only curbed AR Y267 phosphorylation and subsequent K609 acetylation but also compromised enzalutamide-resistant CRPC xenograft tumor growth in mice. Overall, these data uncover chronological modification events in AR that allows prostate cancer to evolve through progressive stages to reach the resilient recurrent CRPC stage, opening up a therapeutic vulnerability. Resensitizing prostate cancer to treatment: Tumors that become refractory to antiandrogen therapy are a major barrier to effective treatment of castration-resistant prostate cancer. Sawant et al. found that acetylation of the androgen receptor at a specific residue contributes to enzalutamide resistance in this setting. This acetylation required the function of the nonreceptor tyrosine kinase ACK1. Administration of ACK1 inhibitors resensitized mouse models of castration-resistant prostate cancer to enzalutamide treatment, suggesting a possible therapeutic strategy for this disease. [ABSTRACT FROM AUTHOR]

Copyright of Revista EIA is the property of Escuela de Ingenieria de Antioquia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)