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938 results on '"Green, Patricia"'

207. Crown Duel

Author

Lothrop-Green, Patricia

Subjects
Crown Duel (Book) -- Book reviews, Books -- Book reviews
Published
1997

208. The Magic Cornfield

Author

Lothrop-Green, Patricia

Subjects
The Magic Cornfield (Book) -- Book reviews, Books -- Book reviews
Published
1997

209. Genesis

Author

Green, Patricia Lothrop

Subjects
Genesis (Book) -- Book reviews, Books -- Book reviews
Published
1997

210. T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis

Author

Beech, Jonathan T, Andreakos, Evangelos, Ciesielski, Cathleen J, Green, Patricia, Foxwell, Brian MJ, and Brennan, Fionula M

Subjects
CD3 Complex, Macrophages, T-Lymphocytes, Synovial Membrane, NF-kappa B, Enzyme-Linked Immunosorbent Assay, Cell Communication, Macrophage Activation, Lymphocyte Activation, Coculture Techniques, I-kappa B Kinase, Arthritis, Rheumatoid, Phosphatidylinositol 3-Kinases, Chemokines, CC, Humans, Chemokines, CXC, Research Article
Abstract

We and others have reported that rheumatoid arthritis (RA) synovial T cells can activate human monocytes/macrophages in a contact-dependent manner to induce the expression of inflammatory cytokines, including tumour necrosis factor alpha (TNFalpha). In the present study we demonstrate that RA synovial T cells without further activation can also induce monocyte CC and CXC chemokine production in a contact-dependent manner. The transcription factor NFkappaB is differentially involved in this process as CXC chemokines but not CC chemokines are inhibited after overexpression of IkappaBalpha, the natural inhibitor of NFkappaB. This effector function of RA synovial T cells is also shared by T cells activated with a cytokine cocktail containing IL-2, IL-6 and TNFalpha, but not T cells activated by anti-CD3 cross-linking that mimics TCR engagement. This study demonstrates for the first time that RA synovial T cells as well as cytokine-activated T cells are able to induce monocyte chemokine production in a contact-dependent manner and through NFkappaB-dependent and NFkappaB-independent mechanisms, in a process influenced by the phosphatidyl-inositol-3-kinase pathway. Moreover, this study provides further evidence that cytokine-activated T cells share aspects of their effector function with RA synovial T cells and that their targeting in the clinic has therapeutic potential.

Published
2006

213. Shaman's Circle

Author

Green, Patricia (Dooley) Lothrop

Subjects
Shaman's Circle (Book) -- Book reviews, Books -- Book reviews
Published
1996

217. Consideration Of The Toxicity of Manufactured Nanoparticles.

Author

Haasch, Mary L., McClellan-Green, Patricia, and Oberdörster, Eva

Subjects
*NANOPARTICLES, *TOXICOLOGY, *NANOTUBES, *CARBON, *REACTIVE oxygen species, *LARGEMOUTH bass, *BIOTRANSFORMATION (Metabolism)
Abstract

Fullerene (C60 and single- and multi-wall carbon nanotubes, SWCNT and MWCNT, respectively) is engineered to be redox active and it is thought that the potential toxicity of fullerene exposure is related to the formation of reactive oxygen species. During manufacture, transport or during scientific investigation, there is a potential for human or environmental exposure to nanoparticles. Several studies regarding human exposure have indicated reasons for concern. There is a lack of studies addressing the toxicity of engineered nanoparticles in aquatic species but one study using the fish, largemouth bass, exposed to fullerene has shown increased (10–17-fold) lipid peroxidation (LPO) in the brain. It is likely that repair enzymes or anti-oxidants may have been induced in gill and liver tissues that had reduced LPO compared to control tissues (Oberdörster, 2004). In support of that hypothesis, suppressive subtractive hybridization was used with liver tissue and the biotransformation enzyme, cytochrome P450, specifically CYP2K4, and other oxidoreductases related to metabolism, along with repair enzymes, were increased while proteins related to normal physiological homeostasis were decreased in fullerene-exposed fish. In a new study involving the exposure of a toxicological model fish species, the fathead minnow (Pimephales promelas) to water-soluble fullerene (nC60), uptake and distribution indicated that nC60 elevated LPO in the brain and induced expression of CYP2 family isozymes in the liver. In an in vitro study, BSA-coated SWCNT interfered with biotransformation enzyme activity. These studies taken together provide support to the hypothesis that the toxicity of manufactured nanoparticles is related to oxidative stress and provide insight into possible mechanisms of toxicity as well as providing information for evaluating the risk to aquatic organisms exposed to manufactured nanoparticles. © 2005 American Institute of Physics [ABSTRACT FROM AUTHOR]

Published
2005
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218. Coyote Goes Walking

Author

Green, Patricia Lothrop

Subjects
Coyote Goes Walking (Book) -- Book reviews, Books -- Book reviews
Published
1995

221. The Jungle Book

Author

Green, Patricia Lothrop

Subjects
The Jungle Book (Book) -- Book reviews, Books -- Book reviews
Published
1995

223. The Iron Woman

Author

Green, Patricia Lothrop

Subjects
The Iron Woman (Book) -- Book reviews, Books -- Book reviews
Published
1995

224. Man, Myth and Magic, rev. ed

Author

Green, Patricia Lothrop

Subjects
Man, Myth and Magic, Rev. Ed., Vols. 1-21 (Book) -- Book reviews, Books -- Book reviews
Published
1995

225. Comparative Genomic Sequence Analysis and Isolation of Human and Mouse Alternative EGFR Transcripts Encoding Truncated Receptor Isoforms

Author

Reiter, Jill L., primary, Threadgill, David W., additional, Eley, Greg D., additional, Strunk, Karen E., additional, Danielsen, Andrew J., additional, Schehl Sinclair, Colleen, additional, Pearsall, R.Scott, additional, Green, Patricia J., additional, Yee, Della, additional, Lampland, Andrea L., additional, Balasubramaniam, Swarna, additional, Crossley, Tonia D., additional, Magnuson, Terry R., additional, James, C.David, additional, and Maihle, Nita J., additional

Published
2001
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226. Owl Eyes

Author

Green, Patricia Lothrop

Subjects
Owl Eyes (Book) -- Book reviews, Books -- Book reviews
Published
1994

232. Mundos en Conflicto en Eveline, de James Joyce.

Author

Green, Patricia

Subjects
COGNITIVE processing of language, DEIXIS (Linguistics), POETICS
Abstract

Copyright of Nueva Revista del Pacífico is the property of Universidad de Playa Ancha de Ciencias de la Educacion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

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