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201. No association of consumption of animal foods with risk of ovarian cancer.

Author: Schulz, Mandy, Nöthlings, Ute, Allen, Naomi, Onland-Moret, N Charlotte, Agnoli, Claudia, Engeset, Dagrun, Galasso, Rocco, Wirfält, Elisabet, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Chajes, Veronique, Clavel-Chapelon, Francoise, Ray, Jennifer, Hoffmann, Kurt, Chang-Claude, Jenny, Kaaks, Rudolf, Trichopoulos, Dimitrios, Georgila, Christina, Zourna, Pantelina, Palli, Domenico, Berrino, Franco, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Peeters, Petra H M, Lund, Eiliv, Gram, Inger T, Skeie, Guri, Berglund, Göran, Lundin, Eva, Hallmans, Göran, González, Carlos A, Quirós, José Ramón, Dorronsoro, Miren, Martínez, Carmen, Tormo, Marie-Jose, Barricarte, Aurelio, Bingham, Sheila, Khaw, Kay-Tee, Key, Timothy J A, Jenab, Mazda, Rinaldi, Sabina, Slimani, Nadia, Riboli, Elio, Schulz, Mandy, Nöthlings, Ute, Allen, Naomi, Onland-Moret, N Charlotte, Agnoli, Claudia, Engeset, Dagrun, Galasso, Rocco, Wirfält, Elisabet, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Chajes, Veronique, Clavel-Chapelon, Francoise, Ray, Jennifer, Hoffmann, Kurt, Chang-Claude, Jenny, Kaaks, Rudolf, Trichopoulos, Dimitrios, Georgila, Christina, Zourna, Pantelina, Palli, Domenico, Berrino, Franco, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Peeters, Petra H M, Lund, Eiliv, Gram, Inger T, Skeie, Guri, Berglund, Göran, Lundin, Eva, Hallmans, Göran, González, Carlos A, Quirós, José Ramón, Dorronsoro, Miren, Martínez, Carmen, Tormo, Marie-Jose, Barricarte, Aurelio, Bingham, Sheila, Khaw, Kay-Tee, Key, Timothy J A, Jenab, Mazda, Rinaldi, Sabina, Slimani, Nadia, and Riboli, Elio
Published: 2007

202. Risk of endometrial cancer in relationship to cigarette smoking : Results from the EPIC study.

Author: Al-Zoughool, Mustafa, Dossus, Laure, Kaaks, Rudolf, Clavel-Chapelon, Françoise, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Gauthier, Estelle, Linseisen, Jakob, Chang-Claude, Jenny, Boeing, Heiner, Schulz, Mandy, Trichopoulou, Antonia, Chryssa, Travezea, Trichopoulos, Dimitrios, Berrino, Franco, Palli, Domenico, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H Bas, Boshuizen, Hendriek C, Peeters, Petra H M, Gram, Inger T, Braaten, Tonje, Lund, Eiliv, Chirlaque, Maria-Dolores, Ardanaz, Eva, Agudo, Antonio, Larrañaga, Nerea, Quirós, Jose Ramon, Berglund, Göran, Manjer, Jonas, Lundin, Eva, Hallmans, Göran, Khaw, Kay-Tee, Bingham, Sheila, Allen, Naomi, Key, Tim, Jenab, Mazda, Cust, Anne E, Rinaldi, Sabina, Riboli, Elio, Al-Zoughool, Mustafa, Dossus, Laure, Kaaks, Rudolf, Clavel-Chapelon, Françoise, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Gauthier, Estelle, Linseisen, Jakob, Chang-Claude, Jenny, Boeing, Heiner, Schulz, Mandy, Trichopoulou, Antonia, Chryssa, Travezea, Trichopoulos, Dimitrios, Berrino, Franco, Palli, Domenico, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H Bas, Boshuizen, Hendriek C, Peeters, Petra H M, Gram, Inger T, Braaten, Tonje, Lund, Eiliv, Chirlaque, Maria-Dolores, Ardanaz, Eva, Agudo, Antonio, Larrañaga, Nerea, Quirós, Jose Ramon, Berglund, Göran, Manjer, Jonas, Lundin, Eva, Hallmans, Göran, Khaw, Kay-Tee, Bingham, Sheila, Allen, Naomi, Key, Tim, Jenab, Mazda, Cust, Anne E, Rinaldi, Sabina, and Riboli, Elio
Published: 2007

203. Smoking and Risk of Breast Cancer in a Racially/Ethnically Diverse Population of Mainly Women Who Do Not Drink Alcohol.

Author: Gram, Inger T., Song-Yi Park, Kolonel, Laurence N., Maskarinec, Gertraud, Wilkens, Lynne R., Henderson, Brian E., and Le Marchand, Loïc
Subjects: *BREAST tumor risk factors, *CONFIDENCE intervals, *ALCOHOL drinking, *ETHNIC groups, *LONGITUDINAL method, *QUESTIONNAIRES, *RACE, *RESEARCH funding, *SMOKING, *TIME, *PROPORTIONAL hazards models
Abstract: We prospectively examined the association between smoking and the risk of breast cancer in a racially/ethnically diverse population comprising mainly women who did not drink alcohol. From 1993 to 2010, we followed 83,300 women who were enrolled in the Multiethnic Cohort Study at 45-75 years of age. We identified cancer cases via linkage to the Surveillance, Epidemiology, and End Results Program cancer registries that covered the states of Hawaii and California through December 2010. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals while adjusting for confounders that were decided a priori. During a mean follow-up of 15 years, 4,484 women developed invasive breast cancer. Compared with parous never smokers, women who had smoked for more than 20 pack-years and initiated smoking more than 5 years before their first childbirth had an overall risk of breast cancer that was 35% higher (hazard ratio = 1.35, 95% confidence interval: 1.13, 1.63). Among women who did not drink alcohol, the risk was 40% higher (hazard ratio = 1.40, 95% confidence interval: 1.08,1.81). This higher riskdid not significantly differ among racial/ethnic groups (Pinteraction = 0.82). We found that various measures of smoking exposure were associated with a higher risk of breast cancer, especially smoking initiated many years before first childbirth, and that risk did not differ by alcohol consumption (yes vs. no) or racial/ethnic group. [ABSTRACT FROM AUTHOR]
Published: 2015
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204. Impact of Cigarette Smoking on Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Author: Agudo, Antonio, primary, Bonet, Catalina, additional, Travier, Noémie, additional, González, Carlos A., additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H. Bas, additional, Trichopoulos, Dimitrios, additional, Boffetta, Paolo, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Kaaks, Rudolf, additional, Lukanova, Annekatrin, additional, Schütze, Madlen, additional, Boeing, Heiner, additional, Tjonneland, Anne, additional, Halkjaer, Jytte, additional, Overvad, Kim, additional, Dahm, Christina C., additional, Quirós, J. Ramon, additional, Sánchez, María-José, additional, Larrañaga, Nerea, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas J., additional, Key, Timothy J., additional, Allen, Naomi E., additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Boshuizen, Hendriek, additional, Büchner, Frederike L., additional, Peeters, Petra H.M., additional, Borgquist, Signe, additional, Almquist, Martin, additional, Hallmans, Göran, additional, Johansson, Ingegerd, additional, Gram, Inger T., additional, Lund, Eiliv, additional, Weiderpass, Elisabete, additional, Romieu, Isabelle, additional, and Riboli, Elio, additional
Published: 2012
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205. Fruit and vegetable consumption and risk of epithelial ovarian cancer : the European Prospective Investigation into Cancer and Nutrition.

Author: Schulz, Mandy, Lahmann, Petra H, Boeing, Heiner, Hoffmann, Kurt, Allen, Naomi, Key, Timothy J A, Bingham, Sheila, Wirfält, Elisabet, Berglund, Göran, Lundin, Eva, Hallmans, Göran, Lukanova, Annekatrin, Martínez Garcia, Carmen, González, Carlos A, Tormo, Maria J, Quirós, José R, Ardanaz, Eva, Larrañaga, Nerea, Lund, Eiliv, Gram, Inger T, Skeie, Guri, Peeters, Petra H M, van Gils, Carla H, Bueno-de-Mesquita, H Bas, Büchner, Frederike L, Pasanisi, Patrizia, Galasso, Rocco, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Trichopoulou, Antonia, Kalapothaki, Victoria, Trichopoulos, Dimitrios, Chang-Claude, Jenny, Linseisen, Jakob, Boutron-Ruault, Marie Christine, Touillaud, Marina, Clavel-Chapelon, Françoise, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Tetsche, Mette, Jenab, Mazda, Norat, Teresa, Kaaks, Rudolph, Riboli, Elio, Schulz, Mandy, Lahmann, Petra H, Boeing, Heiner, Hoffmann, Kurt, Allen, Naomi, Key, Timothy J A, Bingham, Sheila, Wirfält, Elisabet, Berglund, Göran, Lundin, Eva, Hallmans, Göran, Lukanova, Annekatrin, Martínez Garcia, Carmen, González, Carlos A, Tormo, Maria J, Quirós, José R, Ardanaz, Eva, Larrañaga, Nerea, Lund, Eiliv, Gram, Inger T, Skeie, Guri, Peeters, Petra H M, van Gils, Carla H, Bueno-de-Mesquita, H Bas, Büchner, Frederike L, Pasanisi, Patrizia, Galasso, Rocco, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Trichopoulou, Antonia, Kalapothaki, Victoria, Trichopoulos, Dimitrios, Chang-Claude, Jenny, Linseisen, Jakob, Boutron-Ruault, Marie Christine, Touillaud, Marina, Clavel-Chapelon, Françoise, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Tetsche, Mette, Jenab, Mazda, Norat, Teresa, Kaaks, Rudolph, and Riboli, Elio
Published: 2005

206. Fruit and vegetable consumption and risk of aggressive and non-aggressive urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition

Author: Ros, Martine M., primary, Bas Bueno-de-Mesquita, H., additional, Kampman, Ellen, additional, Büchner, Frederike L., additional, Aben, Katja K.H., additional, Egevad, Lars, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Clavel-Chapelon, Francoise, additional, Boutron-Ruault, Marie Christine, additional, Morois, Sophie, additional, Kaaks, Rudolf, additional, Teucher, Birgit, additional, Weikert, Steffen, additional, Ruesten, Anne von, additional, Trichopoulou, Antonia, additional, Naska, Androniki, additional, Benetou, Vassiliki, additional, Saieva, Calogero, additional, Pala, Valeria, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, Mattiello, Amalia, additional, Peeters, Petra H.M., additional, van Gils, Carla H., additional, Gram, Inger T., additional, Engeset, Dagrun, additional, Chirlaque, Maria-Dolores, additional, Ardanazx, Eva, additional, Rodríguez, Laudina, additional, Amanio, Pilar, additional, Gonzalez, Carlos A., additional, Sánchez, María José, additional, Ulmert, David, additional, Ernström, Roy, additional, Ljungberg, Börje, additional, Allen, Naomi E., additional, Key, Timothy J., additional, Khaw, Kee-Tee, additional, Wareham, Nick, additional, Slimani, Nadia, additional, Romieu, Isabelle, additional, Kiemeney, Lambertus A., additional, and Riboli, Elio, additional
Published: 2012
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207. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Author: Ros, Martine M, primary, Bueno-de-Mesquita, H Bas, additional, Kampman, Ellen, additional, Aben, Katja KH, additional, Büchner, Frederike L, additional, Jansen, Eugene HJM, additional, van Gils, Carla H, additional, Egevad, Lars, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Boutron-Ruault, Marie Christine, additional, Kvaskoff, Marina, additional, Perquier, Florence, additional, Kaaks, Rudolf, additional, Chang-Claude, Jenny, additional, Weikert, Steffen, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Dilis, Vardis, additional, Palli, Domenico, additional, Pala, Valeria, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Peeters, Petra HM, additional, Gram, Inger T, additional, Skeie, Guri, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Quirós, José Ramón, additional, Sánchez, María José, additional, Buckland, Genevieve, additional, Larrañaga, Nerea, additional, Ehrnström, Roy, additional, Wallström, Peter, additional, Ljungberg, Börje, additional, Hallmans, Göran, additional, Key, Timothy J, additional, Allen, Naomi E, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Brennan, Paul, additional, Riboli, Elio, additional, and Kiemeney, Lambertus A, additional
Published: 2012
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208. Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

Author: Braem, Marieke GM, primary, Onland-Moret, N Charlotte, additional, Schouten, Leo J, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Lukanova, Annekatrin, additional, Dossus, Laure, additional, Floegel, Anna, additional, Boeing, Heiner, additional, Clavel-Chapelon, Francoise, additional, Chabbert-Buffet, Nathalie, additional, Fagherazzi, Guy, additional, Trichopoulou, Antonia, additional, Benetou, Vassiliki, additional, Goufa, Ioulia, additional, Pala, Valeria, additional, Galasso, Rocco, additional, Mattiello, Amalia, additional, Sacerdote, Carlotta, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Gram, Inger T, additional, Lund, Eiliv, additional, Gavrilyuk, Oxana, additional, Sánchez, Maria-José, additional, Quirós, Ramón, additional, Gonzales, Carlos A, additional, Dorronsoro, Miren, additional, Castaño, José M Huerta, additional, Gurrea, Aurelio Barricarte, additional, Idahl, Annika, additional, Ohlson, Nina, additional, Lundin, Eva, additional, Jirstrom, Karin, additional, Wirfalt, Elisabet, additional, Allen, Naomi E, additional, Tsilidis, Konstantinos K, additional, Kaw, Kay-Tee, additional, Bueno-de-Mesquita, H Bas, additional, Dik, Vincent K, additional, Rinaldi, Sabina, additional, Fedirko, Veronika, additional, Norat, Teresa, additional, Riboli, Elio, additional, Kaaks, Rudolf, additional, and Peeters, Petra HM, additional
Published: 2012
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209. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study

Author: Gram, Inger T., primary, Lukanova, Annekatrin, additional, Brill, Ilene, additional, Braaten, Tonje, additional, Lund, Eiliv, additional, Lundin, Eva, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Clavel-Chapelon, Francoise, additional, Chabbert-Buffet, Nathalie, additional, Bamia, Christina, additional, Trichopoulou, Antonia, additional, Zylis, Dimosthenis, additional, Masala, Giovanna, additional, Berrino, Franco, additional, Galasso, Rocco, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Gavrilyuk, Oxana, additional, Kristiansen, Steinar, additional, Rodríguez, Laudina, additional, Bonet, Catalina, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Sánchez, Maria-José, additional, Dorronsoro, Miren, additional, Jirström, Karin, additional, Almquist, Martin, additional, Idahl, Annika, additional, Bueno-de-Mesquita, H. Bas, additional, Braem, Marie, additional, Onland-Moret, Charlotte, additional, Tsilidis, Konstantinos K., additional, Allen, Naomi E., additional, Fedirko, Veronika, additional, Riboli, E., additional, and Kaaks, Rudolf, additional
Published: 2011
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210. Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition

Author: Tsilidis, Konstantinos K., primary, Allen, Naomi E., additional, Key, Timothy J., additional, Dossus, Laure, additional, Kaaks, Rudolf, additional, Bakken, Kjersti, additional, Lund, Eiliv, additional, Fournier, Agnès, additional, Dahm, Christina C., additional, Overvad, Kim, additional, Hansen, Louise, additional, Tjønneland, Anne, additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Boutron-Ruault, Marie-Christine, additional, Clavel-Chapelon, Francoise, additional, Lukanova, Annekatrin, additional, Boeing, Heiner, additional, Schütze, Madlen, additional, Benetou, Vassiliki, additional, Palli, Domenico, additional, Berrino, Franco, additional, Galasso, Rocco, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, H. Bas, additional, van Duijnhoven, Fränzel J. B., additional, Braem, Marieke G. M., additional, Onland-Moret, N. Charlotte, additional, Gram, Inger T., additional, Rodríguez, Laudina, additional, Duell, Eric J., additional, Sánchez, María-José, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, and Riboli, Elio, additional
Published: 2011
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211. Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Jakszyn, Paula, primary, González, Carlos A., additional, Luján-Barroso, Leila, additional, Ros, Martine M., additional, Bueno-de-Mesquita, H. Bas, additional, Roswall, Nina, additional, Tjønneland, Anne M., additional, Büchner, Frederike L., additional, Egevad, Lars, additional, Overvad, Kim, additional, Raaschou-Nielsen, Ole, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Touillaud, Marina S., additional, Chang-Claude, Jenny, additional, Allen, Naomi E., additional, Kiemeney, Lambertus A., additional, Key, Timothy J., additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Weikert, Steffen, additional, Trichopoulou, Antonia, additional, Oikonomou, Eleni, additional, Zylis, Dimosthenis, additional, Palli, Domenico, additional, Berrino, Franco, additional, Vineis, Paolo, additional, Tumino, Rosario, additional, Mattiello, Amalia, additional, Peeters, Petra H.M., additional, Parr, Christine L., additional, Gram, Inger T., additional, Skeie, Guri, additional, Sánchez, Maria-Jose, additional, Larrañaga, Nerea, additional, Ardanaz, Eva, additional, Navarro, Carmen, additional, Rodríguez, Laudina, additional, Ulmert, David, additional, Ehrnström, Roy, additional, Hallmans, Göran, additional, Ljungberg, Borje, additional, Roddam, Andrew Wilfred, additional, Bingham, Sheila A., additional, Khaw, Kay-Tee, additional, Slimani, Nadia, additional, Boffetta, Paolo A., additional, Jenab, Mazda, additional, Mouw, Traci, additional, Michaud, Dominique S., additional, and Riboli, Elio, additional
Published: 2011
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212. Cigarette Smoking and Colorectal Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition Study

Author: Leufkens, Anke M., primary, Van Duijnhoven, Fränzel J.B., additional, Siersema, Peter D., additional, Boshuizen, Hendriek C., additional, Vrieling, Alina, additional, Agudo, Antonio, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, Dahm, Christina, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Boutron–Ruault, Marie–Christine, additional, Clavel–Chapelon, Françoise, additional, Morois, Sophie, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Sacerdote, Charlotta, additional, Mattiello, Amalia, additional, Herman, Silke, additional, Kaaks, Rudolf, additional, Steffen, Annika, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Trichopoulos, Dimitrios, additional, Peeters, Petra H., additional, van Gils, Carla H., additional, van Kranen, Henk, additional, Lund, Eliv, additional, Dumeaux, Vanessa, additional, Engeset, Dagrun, additional, Rodríguez, Laudina, additional, Sánchez, Maria–José, additional, Chirlaque, Maria–Dolores, additional, Barricarte, Aurelio, additional, Manjer, Jonas, additional, Almquist, Martin, additional, van Guelpen, Bethany, additional, Hallmans, Göran, additional, Khaw, Kay–Tee, additional, Wareham, Nick, additional, Tsilidis, Konstantinos K., additional, Straif, Kurt, additional, Leon–Roux, Maria, additional, Vineis, Paul, additional, Norat, Teresa, additional, Riboli, Elio, additional, and Bueno–de–Mesquita, H. Bas, additional
Published: 2011
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213. Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Büchner, Frederike L., primary, Bueno‐de‐Mesquita, H. Bas, additional, Ros, Martine M., additional, Kampman, Ellen, additional, Egevad, Lars, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Clavel‐Chapelon, Françoise, additional, Boutron‐Ruault, Marie‐Christine, additional, Touillaud, Marina, additional, Kaaks, Rudolf, additional, Chang‐Claude, Jenny, additional, Boeing, Heiner, additional, Weikert, Steffen, additional, Trichopoulou, Antonia, additional, Naska, Ada, additional, Benetou, Vicky, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Vineis, Paolo, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, van Duijnhoven, Fränzel J.B., additional, Peeters, Petra H.M., additional, van Gils, Carla H., additional, Lund, Eiliv, additional, Gram, Inger T., additional, Sánchez, Maria‐José, additional, Jakszyn, Paula, additional, Larrañaga, Nerea, additional, Ardanaz, Eva, additional, Navarro, Carmen, additional, Rodríguez, Laudina, additional, Manjer, Jonas, additional, Ehrnström, Roy, additional, Hallmans, Göran, additional, Ljungberg, Börje, additional, Key, Tim J., additional, Allen, Naomi E., additional, Khaw, Kay‐Tee, additional, Wareham, Nicholas, additional, Slimani, Nadia, additional, Jenab, Mazda, additional, Boffetta, Paolo, additional, Kiemeney, Lambertus A.L.M, additional, and Riboli, Elio, additional
Published: 2010
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214. Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Ros, Martine M., primary, Bas Bueno-de-Mesquita, H.B., additional, Büchner, Frederike L., additional, Aben, Katja K.H., additional, Kampman, Ellen, additional, Egevad, Lars, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Clavel-Chapelon, Francoise, additional, Kaaks, Rudolf, additional, Chang-Claude, Jenny, additional, Boeing, Heiner, additional, Weikert, Steffen, additional, Trichopoulou, Antonia, additional, Orfanos, Philippos, additional, Stasinopulou, Georgia, additional, Saieva, Calogero, additional, Krogh, Vittorio, additional, Vineis, Paolo, additional, Tumino, Rosario, additional, Mattiello, Amalia, additional, Peeters, Petra H.M., additional, van Duijnhoven, Fränzel J.B., additional, Lund, Eiliv, additional, Gram, Inger T, additional, Chirlaque, Maria D, additional, Barricarte, Aurelio, additional, Rodríguez, Laudina, additional, Molina, Esther, additional, Gonzalez, Carlos, additional, Dorronsoro, Miren, additional, Manjer, Jonas, additional, Ehrnström, Roy, additional, Ljungberg, Börje, additional, Allen, Naomi E., additional, Roddam, Andrew W., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Boffetta, Paolo, additional, Slimani, Nadia, additional, Michaud, Dominique S., additional, Kiemeney, Lambertus A.L.M., additional, and Riboli, Elio, additional
Published: 2010
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215. Reproductive Factors and Exogenous Hormone Use in Relation to Risk of Glioma and Meningioma in a Large European Cohort Study

Author: Michaud, Dominique S., primary, Gallo, Valentina, additional, Schlehofer, Brigitte, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Dahm, Christina C., additional, Kaaks, Rudolf, additional, Lukanova, Annekatrin, additional, Boeing, Heiner, additional, Schütze, Madlen, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Kyrozis, Andreas, additional, Sacerdote, Carlotta, additional, Agnoli, Claudia, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Mattiello, Amalia, additional, Bueno-de-Mesquita, H. Bas, additional, Ros, Martine M., additional, Peeters, Petra H. M., additional, van Gils, Carla H., additional, Lund, Eiliv, additional, Bakken, Kjersti, additional, Gram, Inger T., additional, Barricarte, Aurelio, additional, Navarro, Carmen, additional, Dorronsoro, Miren, additional, Sánchez, Maria José, additional, Rodríguez, Laudina, additional, Duell, Eric J., additional, Hallmans, Göran, additional, Melin, Beatrice S., additional, Manjer, Jonas, additional, Borgquist, Signe, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Allen, Naomi E., additional, Tsilidis, Konstantinos K., additional, Romieu, Isabelle, additional, Rinaldi, Sabina, additional, Vineis, Paolo, additional, and Riboli, Elio, additional
Published: 2010
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216. Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Büchner, Frederike L., primary, Bueno-de-Mesquita, H. Bas, additional, Ros, Martine M., additional, Overvad, Kim, additional, Dahm, Christina C., additional, Hansen, Louise, additional, Tjønneland, Anne, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Touillaud, Marina, additional, Kaaks, Rudolf, additional, Rohrmann, Sabine, additional, Boeing, Heiner, additional, Nöthlings, Ute, additional, Trichopoulou, Antonia, additional, Zylis, Dimosthenis, additional, Dilis, Vardis, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Vineis, Paolo, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Peeters, Petra H.M., additional, van Gils, Carla H., additional, Lund, Eiliv, additional, Gram, Inger T., additional, Braaten, Tonje, additional, Sánchez, María-José, additional, Agudo, Antonio, additional, Larrañaga, Nerea, additional, Ardanaz, Eva, additional, Navarro, Carmen, additional, Argüelles, Marcial V., additional, Manjer, Jonas, additional, Wirfält, Elisabet, additional, Hallmans, Göran, additional, Rasmuson, Torgny, additional, Key, Tim J., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Slimani, Nadia, additional, Vergnaud, Anne-Claire, additional, Xun, Wei W., additional, Kiemeney, Lambertus A.L.M., additional, and Riboli, Elio, additional
Published: 2010
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217. A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Crowe, Francesca L., primary, Key, Timothy J., additional, Allen, Naomi E., additional, Appleby, Paul N., additional, Overvad, Kim, additional, Grønbæk, Henning, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Dossus, Laure, additional, Boeing, Heiner, additional, Kröger, Janine, additional, Trichopoulou, Antonia, additional, Zylis, Dimosthenis, additional, Trichopoulos, Dimitrios, additional, Boutron-Ruault, Marie-Christine, additional, de Lauzon-Guillain, Blandine, additional, Clavel-Chapelon, Françoise, additional, Palli, Domenico, additional, Berrino, Franco, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, H Bas, additional, van Gils, Carla H., additional, Peeters, Petra H. M., additional, Gram, Inger T., additional, Rodríguez, Laudina, additional, Jakszyn, Paula, additional, Molina-Montes, Esther, additional, Navarro, Carmen, additional, Barricarte, Aurelio, additional, Larrañaga, Nerea, additional, Khaw, Kay-Tee, additional, Rodwell, Sheila, additional, Rinaldi, Sabina, additional, Slimani, Nadia, additional, Norat, Teresa, additional, Gallo, Valentina, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional
Published: 2010
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218. Abstract 1831: Cigarette smoking and risk of epithelial ovarian cancer according to histological subtypes: results from the EPIC study

Author: Gram, Inger T., primary, Braaten, Tonje, additional, Brill, Ilene, additional, Lund, Eiliv, additional, Dossus, Laure, additional, Kaaks, Rudolf, additional, Lukanova, Annekatrin, additional, and Lundin, Eva, additional
Published: 2010
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219. Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

Author: Biong, Margarethe, primary, Gram, Inger T, additional, Brill, Ilene, additional, Johansen, Fredrik, additional, Solvang, Hiroko K, additional, Alnaes, Grethe IG, additional, Fagerheim, Toril, additional, Bremnes, Yngve, additional, Chanock, Stephen J, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Ursin, Giske, additional, and Kristensen, Vessela N, additional
Published: 2010
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220. The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition

Author: Crowe, Francesca L., primary, Key, Timothy J., additional, Allen, Naomi E., additional, Appleby, Paul N., additional, Roddam, Andrew, additional, Overvad, Kim, additional, Grønbæk, Henning, additional, Tjønneland, Anne, additional, Halkjær, Jutte, additional, Dossus, Laure, additional, Boeing, Heiner, additional, Kröger, Janine, additional, Trichopoulou, Antonia, additional, Dilis, Vardis, additional, Trichopoulos, Dimitrios, additional, Boutron-Ruault, Marie-Christine, additional, De Lauzon, Blandine, additional, Clavel-Chapelon, Françoise, additional, Palli, Domenico, additional, Berrino, Franco, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, H. Bas, additional, Vrieling, Alina, additional, van Gils, Carla H., additional, Peeters, Petra H.M., additional, Gram, Inger T., additional, Skeie, Guri, additional, Lund, Eiliv, additional, Rodríguez, Laudina, additional, Jakszyn, Paula, additional, Molina-Montes, Esther, additional, Tormo, María J., additional, Barricarte, Aurelio, additional, Larrañaga, Nerea, additional, Khaw, Kay-Tee, additional, Bingham, Sheila, additional, Rinaldi, Sabina, additional, Slimani, Nadia, additional, Norat, Teresa, additional, Gallo, Valentina, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional
Published: 2009
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221. T1983 Cigarette Smoking and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Author: Leufkens, Anke M., primary, van Duijnhoven, Fränzel J., additional, Siersema, Peter D., additional, Vrieling, Alina, additional, Agudo, Antonio, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, and Bueno-de-Mesquita, Bas B., additional
Published: 2009
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222. Cigarette smoking and risk of colorectal cancer among Norwegian women

Author: Gram, Inger T., primary, Braaten, Tonje, additional, Lund, Eiliv, additional, Le Marchand, Loic, additional, and Weiderpass, Elisabete, additional
Published: 2009
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223. Different measures of smoking exposure and mammographic density in postmenopausal Norwegian women: a cross-sectional study

Author: Bremnes, Yngve, primary, Ursin, Giske, additional, Bjurstam, Nils, additional, and Gram, Inger T, additional
Published: 2007
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224. No Association of Consumption of Animal Foods with Risk of Ovarian Cancer

Author: Schulz, Mandy, primary, Nöthlings, Ute, additional, Allen, Naomi, additional, Onland-Moret, N. Charlotte, additional, Agnoli, Claudia, additional, Engeset, Dagrun, additional, Galasso, Rocco, additional, Wirfält, Elisabet, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Chajes, Veronique, additional, Clavel-Chapelon, Francoise, additional, Ray, Jennifer, additional, Hoffmann, Kurt, additional, Chang-Claude, Jenny, additional, Kaaks, Rudolf, additional, Trichopoulos, Dimitrios, additional, Georgila, Christina, additional, Zourna, Pantelina, additional, Palli, Domenico, additional, Berrino, Franco, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, H. Bas, additional, Ocké, Marga C., additional, Peeters, Petra H.M., additional, Lund, Eiliv, additional, Gram, Inger T., additional, Skeie, Guri, additional, Berglund, Göran, additional, Lundin, Eva, additional, Hallmans, Göran, additional, González, Carlos A., additional, Quirós, José Ramón, additional, Dorronsoro, Miren, additional, Martínez, Carmen, additional, Tormo, Marie-Jose, additional, Barricarte, Aurelio, additional, Bingham, Sheila, additional, Khaw, Kay-Tee, additional, Key, Timothy J.A., additional, Jenab, Mazda, additional, Rinaldi, Sabina, additional, Slimani, Nadia, additional, and Riboli, Elio, additional
Published: 2007
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225. Risk of endometrial cancer in relationship to cigarette smoking: Results from the EPIC study

Author: Al-Zoughool, Mustafa, primary, Dossus, Laure, additional, Kaaks, Rudolf, additional, Clavel-Chapelon, Françoise, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Gauthier, Estelle, additional, Linseisen, Jakob, additional, Chang-Claude, Jenny, additional, Boeing, Heiner, additional, Schulz, Mandy, additional, Trichopoulou, Antonia, additional, Chryssa, Travezea, additional, Trichopoulos, Dimitrios, additional, Berrino, Franco, additional, Palli, Domenico, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, H. Bas, additional, Boshuizen, Hendriek C., additional, Peeters, Petra H.M., additional, Gram, Inger T., additional, Braaten, Tonje, additional, Lund, Eiliv, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Agudo, Antonio, additional, Larrañaga, Nerea, additional, Quirós, Jose Ramon, additional, Berglund, Göran, additional, Manjer, Jonas, additional, Lundin, Eva, additional, Hallmans, Göran, additional, Khaw, Kay-Tee, additional, Bingham, Sheila, additional, Allen, Naomi, additional, Key, Tim, additional, Jenab, Mazda, additional, Cust, Anne E., additional, Rinaldi, Sabina, additional, and Riboli, Elio, additional
Published: 2007
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226. Insulin-like Growth Factor and Mammographic Density in Postmenopausal Norwegian Women

Author: Bremnes, Yngve, primary, Ursin, Giske, additional, Bjurstam, Nils, additional, Rinaldi, Sabina, additional, Kaaks, Rudolf, additional, and Gram, Inger T., additional
Published: 2007
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227. Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

Author: Gram, Inger T., primary, Braaten, Tonje, additional, Adami, Hans-Olov, additional, Lund, Eiliv, additional, and Weiderpass, Elisabete, additional
Published: 2007
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228. Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study

Author: Stuedal, Anne, primary, Ursin, Giske, additional, Veierød, Marit B, additional, Bremnes, Yngve, additional, Reseland, Janne E, additional, Drevon, Christian A, additional, and Gram, Inger T, additional
Published: 2006
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229. Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer: The European Prospective Investigation into Cancer and Nutrition

Author: Schulz, Mandy, primary, Lahmann, Petra H., additional, Boeing, Heiner, additional, Hoffmann, Kurt, additional, Allen, Naomi, additional, Key, Timothy J.A., additional, Bingham, Sheila, additional, Wirfält, Elisabet, additional, Berglund, Göran, additional, Lundin, Eva, additional, Hallmans, Göran, additional, Lukanova, Annekatrin, additional, Martínez Garcia, Carmen, additional, González, Carlos A., additional, Tormo, Maria J., additional, Quirós, José R., additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Lund, Eiliv, additional, Gram, Inger T., additional, Skeie, Guri, additional, Peeters, Petra H.M., additional, van Gils, Carla H., additional, Bueno-de-Mesquita, H. Bas, additional, Büchner, Frederike L., additional, Pasanisi, Patrizia, additional, Galasso, Rocco, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Trichopoulou, Antonia, additional, Kalapothaki, Victoria, additional, Trichopoulos, Dimitrios, additional, Chang-Claude, Jenny, additional, Linseisen, Jakob, additional, Boutron-Ruault, Marie Christine, additional, Touillaud, Marina, additional, Clavel-Chapelon, Françoise, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Tetsche, Mette, additional, Jenab, Mazda, additional, Norat, Teresa, additional, Kaaks, Rudolph, additional, and Riboli, Elio, additional
Published: 2005
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230. Percentage density, Wolfe's and Tabár's mammographic patterns: agreement and association with risk factors for breast cancer

Author: Gram, Inger T, primary, Bremnes, Yngve, additional, Ursin, Giske, additional, Maskarinec, Gertraud, additional, Bjurstam, Nils, additional, and Lund, Eiliv, additional
Published: 2005
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231. Breast Cancer Risk Among Women Who Start Smoking as Teenagers

Author: Gram, Inger T., primary, Braaten, Tonje, additional, Terry, Paul D., additional, Sasco, Annie J., additional, Adami, Hans-Olov, additional, Lund, Eiliv, additional, and Weiderpass, Elisabete, additional
Published: 2005
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232. Clinical Impact of Atypical Squamous Cells of Undetermined Significance

Author: Lousuebsakul, Vichuda, primary, Knutsen, Synnove M.F., additional, Gram, Inger T., additional, and Akin, Marie-Rose M., additional
Published: 2000
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233. Cigarette smoking and colorectal cancer mortality among 602,242 Norwegian males and females.

Author: Parajuli, Ranjan, Bjerkaas, Eivind, Tverdal, Aage, Le Marchand, Loïc, Weiderpass, Elisabete, and Gram, Inger T.
Subjects: SMOKING, COLON cancer, CANCER-related mortality, HEALTH of cigarette smokers, RECTAL cancer, CANCER risk factors, MORTALITY risk factors
Abstract: Background: Colorectal cancer (CRC) is one of the main cancer types, with high incidence and mortality in Norway. We examined the association between different measures of smoking exposure and CRC mortality overall and by subsite in a large Norwegian cohort. Methods: We followed 602,242 participants from four Norwegian health surveys, aged 19-67 years at enrollment between 1972 and 2003 by linkage to the national registries through December 2007. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) by smoking categories for different CRC endpoints. Results: During a mean follow-up of 14 years, 2,333 Norwegian males and females died of CRC (60% men). Male and female ever smokers had a 20% (HR 1.23, CI 1.08-1.40 and HR 1.22, 95% CI 1.06-1.40, respectively) increased risk of death from CRC compared with sex-specific never smokers. For proximal colon cancer mortality, female ever smokers had a 50% (HR 1.49, 95% CI 1.20-1.87) increased risk compared with female never smokers. The increased risk of rectal cancer mortality was about 40% higher for male ever smokers (HR 1.43, 95% CI 1.14-1.81) compared with male never smokers. A test for heterogeneity by sex showed an increased risk of rectal cancer mortality among men which was significant for former smokers (Wald χ2=0.02) and an increased risk of proximal colon cancer mortality among women which was significant for ever and former smokers (Wald χ2=0.02 and χ2=0.04, respectively). Conclusion: Smoking is associated with increased CRC mortality in both sexes. The risk of rectal and proximal colon cancer mortality was most pronounced among male and female smokers respectively. [ABSTRACT FROM AUTHOR]
Published: 2014
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234. Anthropometric indices in relation to mammographic patterns among peri-menopausal women

Author: Gram, Inger T., primary, Funkhouser, Ellen, additional, and Tabar, Laszlo, additional
Published: 1997
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235. The Tabár classification of mammographic parenchymal patterns

Author: Gram, Inger T., primary, Funkhouser, Ellen, additional, and Tabár, László, additional
Published: 1997
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236. Reply

Author: Gram, Inger T., primary, Macaluso, Maurizio, additional, and Stalsberg, Helge, additional
Published: 1993
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237. Cigarette Smoking and the Incidence of Cervical Intraepithelial Neoplasia, Grade III, and Cancer of the Cervix Uteri

Author: Gram, Inger T., primary, Austin, Harland, additional, and Stalsberg, Helge, additional
Published: 1992
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238. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study.

Author: Gram, Inger T., Lukanova, Annekatrin, Brill, Ilene, Braaten, Tonje, Lund, Eiliv, Lundin, Eva, Overvad, Kim, Tjønneland, Anne, Clavel-Chapelon, Francoise, Chabbert-Buffet, Nathalie, Bamia, Christina, Trichopoulou, Antonia, Zylis, Dimosthenis, Masala, Giovanna, Berrino, Franco, Galasso, Rocco, Tumino, Rosario, Sacerdote, Carlotta, Gavrilyuk, Oxana, and Kristiansen, Steinar
Abstract: New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.08-3.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.26-4.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.07-4.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype. [ABSTRACT FROM AUTHOR]
Published: 2012
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239. Is Colposcopic Biopsy Overused among Women with a Cytological Diagnosis of Atypical Squamous Cells of Undetermined Significance (ASCUS)?

Author: Lousuebsakul, Vichuda, Knutsen, Synnove M.F., Singh, Pramil N., and Gram, Inger T.
Subjects: COLPOSCOPY, PAP test, BIOPSY, CANCER, WOMEN'S health, DISEASES in women
Abstract: The article examines variable associated with the method of follow-up for colposcopic biopsy or repeat Pap smear in a sample of 651 women in the U.S. The women were diagnosed with atypical squamous cells of undetermined significance (ASCUS) and were then referred for either a colposcopic biopsy or a repeat PAP smear at their next follow-up appointment. The cytoloxical classification of ASCUS is used to identity cellular abnormalities that lack the definitive cytological morphologies needed for a definitive diagnosis of squamous intraepithelial lesion. About 3% of women in the U.S. can be classified as having ASCUS. It is not necessarily a precursor to cervical cancer. The article informs that high income is positively associated with odds of colposcopic biopsy in all strata of health coverage and that among those in the highest income category, private insurance remained an indicator of colposcopic biopsy use. It further adds that there is an overuse of colposcopic biopsy by high income and privately insured women who are likely to be at low risk of cervical malignancies.
Published: 2003
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240. Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.

Author: Londoño, Catalina, Cayssials, Valerie, de Villasante, Izar, Crous-Bou, Marta, Scalbert, Augustin, Weiderpass, Elisabete, Agudo, Antonio, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Rylander, Charlotta, and Skeie, Guri
Subjects: OVARIAN epithelial cancer, DISEASE risk factors, SEROUS fluids, ADULTS, PHENOLIC acids, BONFERRONI correction
Abstract: Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation [ABSTRACT FROM AUTHOR]
Published: 2021
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241. Development and validation of circulating CA125 prediction models in postmenopausal women

Author: Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A, Fortner, Renée T, Vitonis, Allison F, Yamamoto, Hidemi, Fichorova, Raina N, Titus, Linda J, Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N Charlotte, Weiderpass, Elisabete, Gram, Inger T, Quirós, J Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J, Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W, Tworoger, Shelley S, and Terry, Kathryn L
Subjects: 2. Zero hunger, endocrine system diseases, Early detection, Middle Aged, Models, Theoretical, female genital diseases and pregnancy complications, 3. Good health, Postmenopause, CA125, Ovarian cancer, Prediction model, CA-125 Antigen, Neoplasms, Humans, Postmenopausal, Female, Early Detection of Cancer, Aged
Abstract: BACKGROUND: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker. METHODS: We developed and validated linear and dichotomous (≥35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses' Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. RESULT: The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset. CONCLUSIONS: The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker.

242. Development and validation of circulating CA125 prediction models in postmenopausal women

Author: Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A, Fortner, Renée T, Vitonis, Allison F, Yamamoto, Hidemi, Fichorova, Raina N, Titus, Linda J, Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N Charlotte, Weiderpass, Elisabete, Gram, Inger T, Quirós, J Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J, Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W, Tworoger, Shelley S, and Terry, Kathryn L
Subjects: 2. Zero hunger, CA125, endocrine system diseases, Prediction model, Ovarian cancer, Early Detection, Postmenopausal, female genital diseases and pregnancy complications, 3. Good health
Abstract: BACKGROUND:Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker. METHODS:We developed and validated linear and dichotomous (≥35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses' Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. RESULT:The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset. CONCLUSIONS:The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker.

243. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Author: Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjønneland, Anne, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Gram, Inger T, Skeie, Guri, Rosendahl, Ann H, Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K, Tsilidis, Konstantinos K, and Riboli, Elio
Subjects: *BREAST cancer, *DISEASE risk factors, *BODY mass index, *WEIGHT gain
Abstract: Background: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.Methods: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.Results: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85).Conclusion: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer. [ABSTRACT FROM AUTHOR]
Published: 2021
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244. Prospective analysis of circulating metabolites and endometrial cancer risk.

Author: Dossus, Laure, Kouloura, Eirini, Biessy, Carine, Viallon, Vivian, Siskos, Alexandros P., Dimou, Niki, Rinaldi, Sabina, Merritt, Melissa A., Allen, Naomi, Fortner, Renee, Kaaks, Rudolf, Weiderpass, Elisabete, Gram, Inger T., Rothwell, Joseph A., Lécuyer, Lucie, Severi, Gianluca, Schulze, Matthias B., Nøst, Therese Haugdahl, Crous-Bou, Marta, and Sánchez, Maria-Jose
Subjects: *DISEASE risk factors, *ENDOMETRIAL cancer, *LIQUID chromatography-mass spectrometry, *METABOLITES, *GYNECOLOGIC cancer, *BODY mass index
Abstract: Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry. Conditional logistic regression estimated the associations of metabolites with endometrial cancer risk. An analysis focusing on clusters of metabolites using the bootstrap lasso method was also employed. After adjustment for body mass index, sphingomyelin [SM] C18:0 was positively (OR 1SD : 1.18, 95% CI: 1.05–1.33), and glycine, serine, and free carnitine (C0) were inversely (OR 1SD : 0.89, 95% CI: 0.80–0.99; OR 1SD : 0.89, 95% CI: 0.79–1.00 and OR 1SD : 0.91, 95% CI: 0.81–1.00, respectively) associated with endometrial cancer risk. Serine, C0 and two sphingomyelins were selected by the lasso method in >90% of the bootstrap samples. The ratio of esterified to free carnitine (OR 1SD : 1.14, 95% CI: 1.02–1.28) and that of short chain to free acylcarnitines (OR 1SD : 1.12, 95% CI: 1.00–1.25) were positively associated with endometrial cancer risk. Further adjustment for C-peptide or other endometrial cancer risk factors only minimally altered the results. These findings suggest that variation in levels of glycine, serine, SM C18:0 and free carnitine may represent specific pathways linked to endometrial cancer development. If causal, these pathways may offer novel targets for endometrial cancer prevention. • Endometrial cancer is the most common gynecological cancer in developed countries. • Metabolomics may uncover novel pathways linked to endometrial cancer. • 853 endometrial cancer case-control pairs from EPIC underwent metabolomic profiling. • Specific amino acids, sphingolipids & carnitine were linked to endometrial cancer. • If causal, these pathways may offer novel targets for endometrial cancer prevention. [ABSTRACT FROM AUTHOR]
Published: 2021
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245. Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author: Virginia Menéndez, Crystal Lin, Nina Roswall, Marc J. Gunter, Rudolf Kaaks, Petra H.M. Peeters, Elisabete Weiderpass, Paul N. Appleby, Anne Tjønneland, Inger T. Gram, Maria Dolores Chirlaque, Fredrik Liedberg, Sarah J. Tipper, Lambertus A. Kiemeney, Leila Lujan-Barroso, Elio Riboli, Claudia Agnoli, Elena Salamanca-Fernández, Antonia Trichopoulou, Francesca Romana Manciniveri, Kim Overvad, Timothy J. Key, Gianluca Severi, Eva Ardanaz, Rosario Tumino, Heinz Freisling, Bas Bueno-de-Mesquita, Ruth C. Travis, Giovanna Masala, Jenny Chang-Claude, Carlotta Sacerdote, Börje Ljungberg, Amanda J. Cross, Miren Dorronsoro, Dagfinn Aune, Aurora Perez-Cornago, Marie-Christine Boutron-Ruault, Salvatore Panico, Universitat de Barcelona, Imperial College Trust, Lin, Crystal, Travis, Ruth C, Appleby, Paul N, Tipper, Sarah, Weiderpass, Elisabete, Chang-Claude, Jenny, Gram, Inger T, Kaaks, Rudolf, Kiemeney, Lambertus A, Ljungberg, Börje, Tumino, Rosario, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Boutron-Ruault, Marie-Christine, Manciniveri, Francesca Romana, Severi, Gianluca, Trichopoulou, Antonia, Masala, Giovanna, Sacerdote, Carlotta, Agnoli, Claudia, Panico, Salvatore, Bueno-de-Mesquita, Ba, Peeters, Petra H, Salamanca-Fernández, Elena, Chirlaque, Maria-Dolore, Ardanaz, Eva, Dorronsoro, Miren, Menéndez, Virginia, Luján-Barroso, Leila, Liedberg, Fredrik, Freisling, Heinz, Gunter, Marc, Aune, Dagfinn, Cross, Amanda J, Riboli, Elio, Key, Timothy J, and Perez-Cornago, Aurora
Subjects: 0301 basic medicine, Oncology, Male, Cancer Research, EPIC cohort, FACTOR (IGF)-I, Prostate cancer, 0302 clinical medicine, MOLECULAR SUBTYPES, Prospective Studies, Insulin-Like Growth Factor I, Prospective cohort study, IGF‐I, IGF BINDING PROTEIN-3, Factors de risc en les malalties, Bladder cancer, ASSOCIATION, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, PROSTATE-CANCER, IGF-I, Europe, FACTOR RECEPTOR, 030220 oncology & carcinogenesis, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Cohort, bladder cancer, Female, Life Sciences & Biomedicine, Cancer Epidemiology, Adult, Risk, medicine.medical_specialty, Risk factors in diseases, Short Report, Càncer de bufeta, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Internal medicine, medicine, Humans, 1112 Oncology and Carcinogenesis, VDP::Medisinske Fag: 700, Oncology & Carcinogenesis, PLASMA-LEVELS, METAANALYSIS, Aged, Tumors, Science & Technology, business.industry, Case-control study, Cancer, IGFBP-3, Odds ratio, prospective, medicine.disease, VDP::Medical disciplines: 700, 030104 developmental biology, Urinary Bladder Neoplasms, urothelial cell carcinoma, Case-Control Studies, CELLS, business
Abstract: Previous in vitro and case–control studies have found an association between the insulin‐like growth factor (IGF)‐axis and bladder cancer risk. Circulating concentrations of IGF‐I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre‐diagnostic plasma concentrations of IGF‐I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow‐up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre‐diagnostic circulating IGF‐I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66–1.24, p trend = 0.40) or UCC (n of cases = 776; 0.91, 0.65–1.26, p trend = 0.40). There was no significant evidence of heterogeneity in the association of IGF‐I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (p heterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF‐I concentrations and bladder cancer risk., What's new? Past prospective studies have shown a positive association between circulating insulin‐like growth factor I (IGF‐I) concentration and colorectal, prostate, and breast cancer risk. However, the association between circulating IGF‐I concentrations and bladder cancer risk remains uncertain. Using a nested‐case control study with 843 bladder cancer cases across 9 European countries, for the first time here the authors examined prospectively the association between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer risk. IGF‐I was not associated with overall risk of bladder cancer or urothelial cell carcinoma. Further prospective data, including on tumour aggressiveness, are required to examine the association in greater detail.
Published: 2018

246. Combined effects of smoking and HPV16 in oropharyngeal cancer

Author: J. Ramón Quirós, Gianluca Severi, Domenico Palli, Elio Riboli, David I. Conway, Antonia Trichopoulou, Göran Laurell, Jenny Chang-Claude, Ulla Westin, H. B. Bueno-De-Mesquita, Rosario Tumino, Ruth C. Travis, Kim Overvad, Carmen Navarro, Claire M. Healy, Mattias Johansson, Dagmar Drogan, Nerea Larrañaga, Ariana Znaor, Elisabete Weiderpass, Peter Thomson, Petra H.M. Peeters, Lorenzo Simonato, Sara Grioni, Michael Pawlita, Aurelio Barricarte, Devasena Anantharaman, Pagona Lagiou, Xavier Castellsagué, Tim Waterboer, Françoise Clavel-Chapelon, Ivana Holcatova, Göran Hallmans, Tatiana V. Macfarlane, Aimée R. Kreimer, Kristina Kjærheim, Saitakis George, Franco Merletti, Jerry Polesel, Marie-Christine Boutron-Ruault, Carlotta Sacerdote, Salvatore Panico, Antonio Agudo, Cristina Canova, Paul Brennan, Anne Tjønneland, Rudolf Kaaks, Eiliv Lund, Max Robinson, Wolfgang Ahrens, Johanna Ekström, María José Sánchez, Dimitrios Trichopoulos, Inger T. Gram, David C. Muller, Anantharaman, Devasena, Muller, David C, Lagiou, Pagona, Ahrens, Wolfgang, Holcátová, Ivana, Merletti, Franco, Kjærheim, Kristina, Polesel, Jerry, Simonato, Lorenzo, Canova, Cristina, Castellsague, Xavier, Macfarlane, Tatiana V, Znaor, Ariana, Thomson, Peter, Robinson, Max, Conway, David I, Healy, Claire M, Tjønneland, Anne, Westin, Ulla, Ekström, Johanna, Chang Claude, Jenny, Kaaks, Rudolf, Overvad, Kim, Drogan, Dagmar, Hallmans, Göran, Laurell, Göran, Bueno de Mesquita, H. B, Peeters, Petra H, Agudo, Antonio, Larrañaga, Nerea, Travis, Ruth C, Palli, Domenico, Barricarte, Aurelio, Trichopoulou, Antonia, George, Saitaki, Trichopoulos, Dimitrio, Quirós, J. Ramón, Grioni, Sara, Sacerdote, Carlotta, Navarro, Carmen, Sánchez, María José, Tumino, Rosario, Severi, Gianluca, Boutron Ruault, Marie Christine, Clavel Chapelon, Francoise, Panico, Salvatore, Weiderpass, Elisabete, Lund, Eiliv, Gram, Inger T, Riboli, Elio, Pawlita, Michael, Waterboer, Tim, Kreimer, Aimée R, Johansson, Mattia, Brennan, Paul, University Medical Center Utrecht, and Imperial College Trust
Subjects: 0301 basic medicine, Oncology, Male, Pathology, Epidemiology, Antibodies, Viral, 0302 clinical medicine, Risk Factors, Odds Ratio, Human papillomavirus, head and neck cancer risk, interaction, oropharynx cancer, tobacco smoking, Human papillomavirus 16, Infection and Cancer, 0104 Statistics, HPV infection, General Medicine, Middle Aged, 3. Good health, Europe, Oropharyngeal Neoplasms, 1117 Public Health And Health Services, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, Enzyme-Linked Immunosorbent Assay, 03 medical and health sciences, Internal medicine, medicine, Journal Article, Tobacco Smoking, Humans, Aged, Oropharyngeal disorders, business.industry, Head and neck cancer, Papillomavirus Infections, Case-control study, Cancer, Bayes Theorem, Odds ratio, medicine.disease, 030104 developmental biology, Human papillomaviru, Logistic Models, Case-Control Studies, business, Cancer risk
Abstract: BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.METHODS: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.RESULTS: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.CONCLUSIONS: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.
Published: 2015

247. An epidemiological model for prediction of endometrial cancer risk in Europe

Author: Anika Hüsing, Christina Bamia, Eva Ardanaz, Guy Fagherazzi, Sabina Rinaldi, Petra H.M. Peeters, Salvatore Panico, Michalis Katsoulis, Emilio Sánchez-Cantalejo, Kay-Tee Khaw, H. Bas Bueno-de-Mesquita, N. Charlotte Onland-Moret, Marc J. Gunter, Carmen Navarro, Melissa A. Merritt, Nicholas J. Wareham, Inger T. Gram, Vittorio Krogh, Louise Hansen, Heiner Boeing, Anne Tjønneland, Isabelle Romieu, Helena Schock, Annika Steffen, Nerea Etxezarreta, Rudolf Kaaks, Laure Dossus, Pietro Ferrari, Domenico Palli, Antonia Trichopoulou, Jenny Chang-Claude, Elio Riboli, Laura Baglietto, Mireia Obón-Santacana, Elisabete Weiderpass, Naomi E. Allen, Hüsing, Anika, Dossus, Laure, Ferrari, Pietro, Tjønneland, Anne, Hansen, Louise, Fagherazzi, Guy, Baglietto, Laura, Schock, Helena, Chang Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Bamia, Christina, Katsoulis, Michali, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Onland Moret, N. Charlotte, Peeters, Petra H, Bueno de Mesquita, H. Ba, Weiderpass, Elisabete, Gram, Inger T, Ardanaz, Eva, Obón Santacana, Mireia, Navarro, Carmen, Sánchez Cantalejo, Emilio, Etxezarreta, Nerea, Allen, Naomi E, Khaw, Kay Tee, Wareham, Nick, Rinaldi, Sabina, Romieu, Isabelle, Merritt, Melissa A, Gunter, Marc, Riboli, Elio, and Kaaks, Rudolf
Subjects: Epidemiology, Risk model, Predictive Value of Test, Body Mass Index, 0302 clinical medicine, Endometrial cancer, Risk Factors, Prevention, Medicine, Prospective Studies, Non-U.S. Gov't, Prospective cohort study, Public, Environmental & Occupational Health, 030219 obstetrics & reproductive medicine, Incidence (epidemiology), Research Support, Non-U.S. Gov't, Incidence, Middle Aged, European Prospective Investigation into Cancer and Nutrition, Europe, POSTMENOPAUSAL WOMEN, 1117 Public Health And Health Services, 030220 oncology & carcinogenesis, Cohort, NUTRITION, Female, Menopause, Risk assessment, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, CARCINOMA, HORMONE-THERAPY, Research Support, Models, Biological, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Journal Article, Humans, Endometrial Neoplasm, COHORT, METAANALYSIS, Aged, Gynecology, Science & Technology, business.industry, medicine.disease, Endometrial Neoplasms, Prospective Studie, business, Body mass index, Demography
Abstract: Endometrial cancer (EC) is the fourth most frequent cancer in women in Europe, and as its incidence is increasing, prevention strategies gain further pertinence. Risk prediction models can be a useful tool for identifying women likely to benefit from targeted prevention measures. On the basis of data from 201,811 women (mostly aged 30–65 years) including 855 incident EC cases from eight countries in the European Prospective Investigation into Cancer and Nutrition cohort, a model to predict EC was developed. A step-wise model selection process was used to select confirmed predictive epidemiologic risk factors. Piece-wise constant hazard rates in 5-year age-intervals were estimated in a cause-specific competing risks model, five-fold-cross-validation was applied for internal validation. Risk factors included in the risk prediction model were body-mass index (BMI), menopausal status, age at menarche and at menopause, oral contraceptive use, overall and by different BMI categories and overall duration of use, parity, age at first full-term pregnancy, duration of menopausal hormone therapy and smoking status (specific for pre, peri- and post-menopausal women). These variables improved the discriminating capacity to predict risk over 5 years from 71 % for a model based on age alone to 77 % (overall C statistic), and the model was well-calibrated (ratio of expected to observed cases = 0.99). Our model could be used for the identification of women at increased risk of EC in Western Europe. To achieve an EC-risk model with general validity, a large-scale cohort-consortium approach would be needed to assess and adjust for population variation.
Published: 2015

248. Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients.

Author: Li J, Roshelli Baker J, Aglago EK, Zhao Z, Jiao L, Freisling H, Hughes DJ, Eriksen AK, Tjønneland A, Severi G, Katzke V, Kaaks R, Schulze MB, Masala G, Pala V, Pasanisi F, Tumino R, Padroni L, Vermeulen RCH, Gram IT, Braaten T, Jakszyn PG, Sánchez MJ, Gómez-Gómez JH, Moreno-Iribas C, Amiano P, Papier K, Weiderpass E, Huybrechts I, Heath AK, Schalkwijk C, Jenab M, and Fedirko V
Subjects: Humans, Male, Female, Middle Aged, Aged, Prospective Studies, Lysine blood, Lysine analogs & derivatives, Ornithine blood, Ornithine analogs & derivatives, Proportional Hazards Models, Biomarkers, Tumor blood, Imidazoles, Colorectal Neoplasms blood, Colorectal Neoplasms mortality, Colorectal Neoplasms diagnosis, Glycation End Products, Advanced blood, Receptor for Advanced Glycation End Products blood
Abstract: Advanced glycation end-products (AGEs), formed endogenously or obtained exogenously from diet, may contribute to chronic inflammation, intracellular signaling alterations, and pathogenesis of several chronic diseases including colorectal cancer (CRC). However, the role of AGEs in CRC survival is less known. The associations of pre-diagnostic circulating AGEs and their soluble receptor (sRAGE) with CRC-specific and overall mortality were estimated using multivariable-adjusted Cox proportional hazards regression among 1369 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Concentrations of major plasma AGEs, N ε -[carboxy-methyl]lysine (CML), N ε -[carboxy-ethyl]lysine (CEL) and N δ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), were measured using ultra-performance liquid chromatography mass-spectrometry. sRAGE was assessed by enzyme-linked immunosorbent assay. Over a mean follow-up period of 96 months, 693 deaths occurred of which 541 were due to CRC. Individual and combined AGEs were not statistically significantly associated with CRC-specific or overall mortality. However, there was a possible interaction by sex for CEL (P interaction = .05). Participants with higher sRAGE had a higher risk of dying from CRC (HR Q5vs.Q1 = 1.67, 95% CI: 1.21-2.30, P trend = .02) or any cause (HR Q5vs.Q1 = 1.38, 95% CI: 1.05-1.83, P trend = .09). These associations tended to be stronger among cases with diabetes (P interaction = .03) and pre-diabetes (P interaction <.01) before CRC diagnosis. Pre-diagnostic AGEs were not associated with CRC-specific and overall mortality in individuals with CRC. However, a positive association was observed for sRAGE. Our findings may stimulate further research on the role of AGEs and sRAGE in survival among cancer patients with special emphasis on potential effect modifications by sex and diabetes., (© 2024 UICC.)
Published: 2024
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249. Smoking Cessation and Short- and Longer-Term Mortality.

Author: Cho ER, Brill IK, Gram IT, Brown PE, and Jha P
Subjects: Adult, Female, Humans, Male, Smokers, Smoking epidemiology, Middle Aged, Aged, Smoking Cessation, Mortality
Abstract: BACKGROUND: Smoking cessation reduces mortality and morbidity. However, the extent and rapidity at which cessation reduces contemporary death rates from smoking-related illnesses remain uncertain. METHODS: We pooled current or former versus never cigarette smoker hazard ratios from four national cohorts with linkage to death registries in the United States, United Kingdom, Norway, and Canada among adults 20 to 79 years of age from 1974 to 2018. We calculated excess risk differences and survival, comparing current or never smokers with age-specific cessation and cessation fewer than 3, 3 to 9, or 10 or more years earlier. RESULTS: Among 1.48 million adults followed for 15 years, 122,697 deaths occurred. Adjusting for age, education, alcohol use, and obesity, current smokers had higher hazard ratios for death compared with never smokers (2.8 for women, 2.7 for men). Survival between 40 and 79 years of age was 12 and 13 years less in women and men, respectively, who smoked compared with never smokers (about 24 to 26 years of life lost for smokers who died from smoking combined with zero loss for smokers who did not die from smoking). Former smokers showed lower hazard ratios (1.3 in both women and men). Short-term cessation for fewer than 3 years was associated with a lower excess risk of 95% in women and 90% in men younger than 40 years of age, with notable beneficial associations also in women and men 40 to 49 years of age (81% and 61%, respectively) and 50 to 59 years of age (63% and 54%, respectively). Cessation at every age was associated with longer survival, particularly cessation before 40 years of age. Among all ages and compared with continued smoking, cessation of fewer than 3 years potentially averted 5 years of life lost and cessation for 10 or more years averted about 10 years of life lost, yielding survival similar to that of never smokers. CONCLUSIONS: Quitting smoking at any age, but particularly in younger years, was associated with lower excess mortality overall and from vascular, respiratory, and neoplastic diseases. Beneficial associations were evident as early as 3 years after cessation. (Funded by Canadian Institutes of Health Research [FDN-154277].)
Published: 2024
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250. Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients.

Author: Mao Z, Baker JR, Takeuchi M, Hyogo H, Tjønneland A, Eriksen AK, Severi G, Rothwell J, Laouali N, Katzke V, Kaaks R, Schulze MB, Palli D, Sieri S, de Magistris MS, Tumino R, Sacerdote C, Derksen JWG, Gram IT, Skeie G, Sandanger TM, Quirós JR, Crous-Bou M, Sánchez MJ, Amiano P, Colorado-Yohar SM, Guevara M, Harlid S, Johansson I, Perez-Cornago A, Freisling H, Gunter M, Weiderpass E, Heath AK, Aglago E, Jenab M, and Fedirko V
Subjects: Humans, Glyceraldehyde, Prospective Studies, Body Mass Index, Glycation End Products, Advanced, Colorectal Neoplasms
Abstract: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HR Q5 vs Q1 = 1.53, 95% CI: 1.04-2.25, P trend = .002) and all-cause (HR Q5 vs Q1 = 1.62, 95% CI: 1.16-2.26, P trend < .001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HR proximal colon = 1.02, 95% CI: 0.74-1.42; HR distal colon = 1.51, 95% CI: 1.20-1.91; P effect modification = .02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted., (© 2023 UICC.)
Published: 2023
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