201. Systemic oxidative stress associates with new-onset hypertension in the general population.
- Author
-
Bourgonje, Arno R., Bourgonje, Martin F., Post, Adrian, la Bastide-van Gemert, Sacha, Kieneker, Lyanne M., Bulthuis, Marian L.C., Gordijn, Sanne J., Gansevoort, Ron T., Bakker, Stephan J.L., Mulder, Douwe J., Pasch, Andreas, van Goor, Harry, and Abdulle, Amaal E.
- Subjects
- *
OXIDATIVE stress , *DIASTOLIC blood pressure , *SYSTOLIC blood pressure , *HYPERTENSION , *ANTIHYPERTENSIVE agents , *CHRONIC kidney failure - Abstract
Oxidative stress is known to be involved in the development of hypertension, but accurate redox biomarkers predicting the risk of developing hypertension are scarce. Serum free sulfhydryl groups (R–SH, free thiols) have been shown to accurately reflect systemic oxidative stress in various conditions. In this study, we aimed to investigate associations between serum free thiols and the risk of developing new-onset hypertension in a population-based cohort study. Subjects (n = 3,575) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) study, a prospective, population-based cohort study in the Netherlands, were included. Baseline protein-adjusted serum free thiols were studied for their associations with the development of hypertension, defined as a systolic blood pressure (SBP) of at least 140 mmHg, a diastolic blood pressure (DBP) of at least 90 mmHg, or the first usage of antihypertensive medication. Subjects with hypertension at baseline were excluded from the study. Mean protein-adjusted serum free thiols at baseline was 5.16 μmol/g of protein (range: 1.62–8.41 μmol/g). Protein-adjusted serum free thiols were significantly associated with the risk of incident hypertension (hazard ratio [HR] per doubling 0.60 [95% confidence interval [CI]: 0.49–0.72, P < 0.001), also after adjustment for age and sex (HR 0.81 [95% CI: 0.66–0.91], P < 0.05), but not after additional adjustment for relevant confounding factors (HR 0.90 [95% CI: 0.70–1.15], P = 0.382). Higher levels of serum free thiols, i.e. less oxidative stress, are associated with a decreased risk of developing incident hypertension in subjects from the general population. [Display omitted] • Oxidative stress is implicated in the pathophysiology of hypertension. • Serum sulfhydryl groups (R–SH) reflect whole-body redox status in health and disease. • Serum R–SH associate with new-onset cardiovascular and renal morbidity in many patient cohorts. • High serum R–SH are associated with a decreased risk of hypertension in the general population. • Serum R–SH may potentially serve as a monitoring tool for future development of cardiovascular diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF