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3,348 results on '"Gonçalves, M."'

202. 704P Characteristics and palliative management of patients with cisplatin-refractory germ cell tumours: A Global Germ Cell Cancer Collaborative Group (G3) retrospective registry study

Author

Oing, C., Seidel, C., Giannatempo, P., Tryakin, A., De Giorgi, U., Sagstuen Haugnes, H., Hentrich, M., Dieing, A., Zschäbitz, S., Gietema, J.A., Fischer, S.C., Fankhauser, C.D., Garcia Del Muro, X., Aparicio, J., Ottaviano, M., Pichler, M., Brito Goncalves, M., Paffenholz, P., Rescigno, P., and Bokemeyer, C.

Published
2024
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204. Encapsulation Studies and In Silico Identification of Protein Targets Associated to the Insecticide Activity of Eugenol Derivatives

Author

Fernandes, Maria José G., Pereira, Renato B., Rodrigues, Ana Rita O., Vieira, Tatiana F., Gil Fortes, A., Pereira, David M., Sousa, Sérgio F., Castanheira, Elisabete M. S., and Sameiro Gonçalves, M.

Subjects
applied_chemistry
Abstract

The eugenol derivative, ethyl 4-(2-methoxy-4-(oxiran-2-ylmethyl)phenoxy)butanoate 1, with promising insecticidal capability was encapsulated in liposomal formulations of egg-phosphatidylcholine/cholesterol (Egg-PC:Ch) 70:30 and of 100% dioleoylphosphatidylglycerol (DOPG). Compound-loaded Egg-PC:Ch liposomes exhibit small hydrodynamic diameters (below 100 nm), high encapsulation efficiency (88.8% ± 2.7%), higher stability and a more efficient compound release, being chosen for assays in Sf9 insect cells. Compound 1 elicited a loss of cell viability up to 80% after 72h of incubation. Relevantly, encapsulation maintained the toxicity of compound 1 towards insect cells, while it lowered toxicity towards human cells, thus showing the selectivity of the system. Structure based inverted virtual screening was used to predict the most likely targets and molecular dynamics simulations and free energy calculations were used to demonstrate that this molecule can form a stable complex with insect odorant binding proteins and/or acetylcholinesterase.

Published
2022

206. Sensory Processing and Occupational Participation

Author

Gonçalves, M. and Abreu, A. M.

Abstract

ABSTRACTChildren with atypical sensory integration have difficulty responding to the processing and/or organization of sensory information, this disability affects functional participation in routines and activities of daily living. Participation is defined as involvement in life situations, it is essential to promote life experiences and the development of sensorimotor, cognitive, and social skills. Improving these skills, in turn, allows children to fully participate in age-appropriate activities and occupations. This study aimed to investigate the putative association between sensory processing and occupational participation in children with neurotypical development. Parents or caregivers of 186 children, aged between 6 and 10 years old, completed the Sensory Profile Caregiver Questionnaires (SPCQ) and the Participation in Childhood Occupations Questionnaire (PICO-Q). Surprisingly, 80 children (43%) presented atypical sensory integration. This sub-group presented several associations between the SPCQ and the areas evaluated by PICO-Q, suggesting an association between sensory processing and occupational participation. We suggest that it is important to carry out screenings for sensory integration in preschool children, to promote better occupational participation in school-aged children.

Published
2023
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207. Clinical features and long-term outcomes of systemic lupus erythematosus: comparative data of childhood, adult and late-onset disease in a national register

Author

Sousa, S., Gonçalves, M. J., Inês, L. S., Eugénio, G., Jesus, D., Fernandes, S., Terroso, G., Romão, V. C., Cerqueira, M., Raposo, A., Couto, M., Nero, P., Sequeira, G., Nóvoa, T., Melo Gomes, J. A., da Silva, J. Canas, Costa, L., Macieira, C., Silva, C., Silva, J. A. P., Canhão, H., and Santos, M. J.

Published
2016
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214. The phenomenology of motivation

Author

André, R., primary, Romão, J., additional, Azevedo, F., additional, Gonçalves, M., additional, Sereijo, C., additional, Saraiva, R., additional, Croca, M., additional, and Abreu, M., additional

Published
2022
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219. Cannabis use and cognitive impairment in schizophrenia

Author

Gonçalves, M., primary, Romão, J., additional, André, R., additional, Félix, F., additional, Andrade, G., additional, Saraiva, R., additional, Dornelles, E., additional, Fernandes, E., additional, Abreu, M., additional, Chendo, I., additional, and Ismail, F., additional

Published
2022
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228. A cubic regularization of Newton’s method with finite difference Hessian approximations

Author

UCL - SST/ICTM/INMA - Pôle en ingénierie mathématique, Nunes Grapiglia, Geovani, Gonçalves, M. L. N., Silva, G. N., UCL - SST/ICTM/INMA - Pôle en ingénierie mathématique, Nunes Grapiglia, Geovani, Gonçalves, M. L. N., and Silva, G. N.

Abstract

In this paper, we present a version of the Cubic Regularization of Newton method for unconstrained nonconvex optimization, in which the Hessian matrices are approximated by forward gradient differences. The regularization parameter of the cubic models and the accuracy of the Hessian approximations are jointly adjusted using a nonmonotone line-search criterion. Assuming that the Hessian of the objective function is Lipschitz continuous, we show that the proposed method needs at most $\mathcal{O}\left(n\epsilon^{-3/2}\right)$ calls of the oracle to generate an $\epsilon$-approximate stationary point, where $n$ is the dimension of the domain of the objective function.

Published
2022

229. Perspectives on design creativity and innovation research: 10 years later

Author

Cascini, G (author), Georgiev, Georgi (author), Zelaya, Jader (author), Becattini, Niccolo (author), Boujut, Jean-François (author), Casakin, Hernan (author), Crilly, Nathan (author), Dekoninck, Elies (author), Gonçalves, M. (author), Cascini, G (author), Georgiev, Georgi (author), Zelaya, Jader (author), Becattini, Niccolo (author), Boujut, Jean-François (author), Casakin, Hernan (author), Crilly, Nathan (author), Dekoninck, Elies (author), and Gonçalves, M. (author)

Abstract

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Methodologie en Organisatie van Design

Published
2022
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230. Working Group on Biological Parameters (WGBIOP) 2021

Author

Follesa, M.C., Hilvarsson, A., Songer, S., Allegaert, W., Basilone, G., Beier, U., Bekaert, K., Berg, F., Blass, M., Canha, A., Carbonara, P., Coad Davies, J., Dubroca, L., Finnbogadóttir, G., Gault, M., Gillespie-Mules, R., Gonçalves, M., Haase, S., Hüssy, K., Kaljuste, M., Korta, M., Kousteni, V., Krüger-Johnsen, M., Krumme, U., Landa, Jorge, Lundgaard, L., Mahé, K., Maxwell, D., Mirny, Z., Ní Chonchúir, G., Pérez-Rodríguez, A., Pinto, C., Torres-Cutillas, Pedro, Ulleweit, J., van Damme, C., Visconti, V., Vitale, F., Follesa, M.C., Hilvarsson, A., Songer, S., Allegaert, W., Basilone, G., Beier, U., Bekaert, K., Berg, F., Blass, M., Canha, A., Carbonara, P., Coad Davies, J., Dubroca, L., Finnbogadóttir, G., Gault, M., Gillespie-Mules, R., Gonçalves, M., Haase, S., Hüssy, K., Kaljuste, M., Korta, M., Kousteni, V., Krüger-Johnsen, M., Krumme, U., Landa, Jorge, Lundgaard, L., Mahé, K., Maxwell, D., Mirny, Z., Ní Chonchúir, G., Pérez-Rodríguez, A., Pinto, C., Torres-Cutillas, Pedro, Ulleweit, J., van Damme, C., Visconti, V., and Vitale, F.

Abstract

The main objective of the Working Group on Biological Parameters (WGBIOP) is to review the status, issues, developments, and quality assurance of biological parameters used in assessment and management. WGBIOP (1) plans workshops, exchanges, and validation studies on a range of biological varia-bles to review the quality of information supplied for stock assessment and improve quality as-surance and training; (2) investigates data availability and develops documentation and methods to improve communication between data collectors and end-users; (3) delivers new and im-proved functionality for the SmartDots platform. Four otolith exchanges and two workshops were completed in 2020–2021 using SmartDots— eight further exchanges are ongoing. Proposed future exchanges and workshops were reviewed and approved. The development of the SmartDots platform proceeded with the inclusion of the maturity, eggs, atresia, fecundity, and larval identification modules into the software version. A live SmartDots tutorial for event coordinators was conducted. Work to further develop quality assurance guidelines—and review national applications of these—progressed. Age and maturity validation studies were reviewed and a new method for prioritizing future validation work was proposed. Progress with the Stock Identification Database (SID) was reviewed, and the potential for creating a WGBIOP library collection and active involvement of WGBIOP in updating FishBase.org data were evaluated. The importance of identifying and documenting links be-tween all relevant databases and document repositories was identified, and a task to address this was initiated. Work on improving the feedback loop between data collectors and stock assessors on the usage and quality of biological parameters in stock assessment continued. Moving forward, WGBIOP aims to continue collaboration with WGALES and WGSMART on the development of the SmartDots platform, encouraging cross-group sharing of skills and ex-perience t

Published
2022

236. Topic: Incisional Hernia — “Easy case” as daily case: open vs lap, where the mesh, which fixation…in center midline cases

Author

Yunis, J., Yamamoto, K., Morishima, Y., Satomi, D., Toshimitsu, Y., Fukutomi, S., Sakakibara, M., Mori, M., Ishige, K., Kobayashi, J., Uccelli, M., Ciccarese, F., Cesana, G., Castello, G., Carrieri, D., Grava, G., Olmi, S., Soliani, G., De Troia, A., Carcoforo, P., Portinari, M., Vasquez, G., Targa, S., Feo, C. V., Duarte de Castro L, B. Simões, Brito, T., Gomes, D., Calais, L., Ferreira, M., Gonçalves, A., Martins, A., Gonçalves, M., Rodrigues, A., Rodrigues, R., Almeida, T., Ventura, J., Lucas, C., Midões, A., Pileci, S., Giaccone, M., Brunetti, M., Camandona, M., Gasparri, G., Ucceli, M., Legnani, G., Nakabayashi, Y., Harada, A., Fujiwara, Y., Sugano, H., Matsumoto, N., Noaki, R., Kurihara, K., Otsuka, M., Mavrodin, C., Pariza, G., Antoniac, I., Dirican, A., Ates, M., Soyer, V., Sarici, B., Kinaci, E., Yilmaz, S., Matsumoto, M., Kazunao, K., Demiryas, S., Demir, I., Kucuk, Y., Umman, V., Orhan, A., Zengin, A. K., Ertem, M., Tasci, I., Christoffersen, M., Brandt, E., Oehlenschläger, J., Rosenberg, J., Helgstrand, F., Jørgensen, L. N., Bardram, L., Bisgaard, T., Bellanova, G., Valduga, R., Beltempo, R., Berlanda, G., Ciarleglio, F. A., Bondioli, R., Marcucci, S., Prezzi, C., and Brolese, A.

Published
2015
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245. AB0501 COMPREHENSIVE ASSESSMENT OF PATIENTS WITH SUSPECTED SJÖGREN’S SYNDROME: 5-YEAR RESULTS OF A MULTIDISCIPLINARY SJÖGREN’S SYNDROME CLINIC

Author

C Romão, V., primary, Sousa Bandeira, M. J., additional, Silvério-António, M., additional, Simão, R., additional, Pinto, J., additional, Gonçalves, A. I., additional, Gonçalves, M. J., additional, Martins, A. L., additional, José, P., additional, Coutinho, G., additional, Morena Bueno Silva, L., additional, Brito Lança, M., additional, Esteves Marques, R., additional, Macieira, C., additional, Khmelinskii, N., additional, Rodrigues, W., additional, Salvado, F., additional, and Fonseca, J. E., additional

Published
2022
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246. POS0496 CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS HAVE ALTERATIONS IN B AND T FOLLICULAR CELL SUBSETS IN PERIPHERAL BLOOD

Author

Tomé, C., primary, Oliveira-Ramos, F., additional, Campanilho-Marques, R., additional, Mourão, A. F., additional, Sousa, S., additional, Martins, A. P., additional, Costa Reis, P., additional, Pinheiro Torres, R., additional, Melo, A. T., additional, Teixeira, R. L., additional, Gonçalves, M., additional, Santos, M. J., additional, Graça, L., additional, Fonseca, J. E., additional, and Moura, R. A., additional

Published
2022
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