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201. Proteomic and Biological Analysis of an In Vitro Human Endothelial System in Response to Drug Anaphylaxis

Author

Alma Yuste-Montalvo, Sergio Fernandez-Bravo, Tamara Oliva, Carlos Pastor-Vargas, Diana Betancor, María José Goikoetxea, José Julio Laguna, Juan Antonio López, Gloria Alvarez-Llamas, Javier Cuesta-Herranz, Marta Martin-Lorenzo, and Vanesa Esteban

Subjects
endothelium, anaphylaxis, proteomics, coagulation and complement systems, drug allergy, system biological analysis, Immunologic diseases. Allergy, RC581-607
Abstract

Anaphylaxis is a life-threatening systemic hypersensitivity reaction. During anaphylaxis, mediator release by effector cells causes endothelial barrier breakdown, increasing vascular permeability and leakage of fluids, which may lead to tissue edema. Although endothelial cells (ECs) are key players in this context, scant attention has been paid to the molecular analysis of the vascular system, and further analyses of this cell type are necessary, especially in humans. The protein expression pattern of human microvascular ECs was analyzed in response to sera from anaphylactic patients (EC-anaphylaxis) and sera from non-allergic subjects (EC-control) after 2 hours of contact. Firstly, a differential quantitative proteomic analysis of the protein extracts was performed by mass spectrometry using an isobaric labeling method. Second, the coordinated behavior of the identified proteins was analyzed using systems biology analysis (SBA). The proteome of the EC-anaphylaxis system showed 7,707 proteins, of which 1,069 were found to be significantly altered between the EC-control and EC-anaphylaxis groups (p-value < 0.05). Among them, a subproteome of 47 proteins presented a high rate of change (|ΔZq| ≥ 3). This panel offers an endothelial snapshot of the anaphylactic reaction. Those proteins with the highest individual changes in abundance were hemoglobin subunits and structural support proteins. The interacting network analysis of this altered subproteome revealed that the coagulation and complement systems are the main biological processes altered in the EC-anaphylactic system. The comprehensive SBA resulted in 5,512 functional subcategories (biological processes), 57 of which were significantly altered between EC-control and EC-anaphylaxis. The complement system, once again, was observed as the main process altered in the EC system created with serum from anaphylactic patients. Findings of the current study further our understanding of the underlying pathophysiological mechanisms operating in anaphylactic reactions. New target proteins and relevant signaling pathways operating in the in vitro endothelial-serum system have been identified. Interestingly, our results offer a protein overview of the micro-EC-anaphylaxis environment. The relevance of the coagulation, fibrinolytic, contact and complement systems in human anaphylaxis is described. Additionally, the untargeted high-throughput analysis used here is a novel approach that reveals new pathways in the study of the endothelial niche in anaphylaxis.

Published
2021
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204. Smart card security

Author

Goikoetxea Yanci, Asier

Subjects
006.2, T Technology (General)
Abstract

Smart Card devices are commonly used on many secure applications where there is a need to identify the card holder in order to provide a personalised service. The value of access to locked data and services makes Smart Cards a desirable attack target for hackers of all sorts. The range of attacks a Smart Card and its environment can be subjected to ranges from social engineering to exploiting hardware and software bugs and features. This research has focused on several hardware related attacks and potential threats. Namely, power glitch attack, power analysis, laser attack, the potential effect on security of memory power consumption reduction techniques and using a re-configurable instruction set as method to harden opcode interpretation. A semi-automated simulation environment to test designs against glitch attacks and power analysis has been developed. This simulation environment can be easily integrated within Atmel’s design flow to bring assurance of their designs’ behaviour and permeability to such attacks at an early development stage. Previous power analysis simulation work focused on testing the implementation of part of the cryptographic algorithm. This work focuses on targeting the whole algorithm, allowing the test of a wider range of countermeasures. A common glitch detection approach is monitoring the power supply for abnormal voltage values and fluctuations. This approach can fail to detect some fast glitches. The alternative approach used in this research monitors the effects of a glitch on a mono-stable circuit sensitive to fault injection by glitch attacks. This work has resulted in a patented glitch detector that improves the overall glitch detection range. The use of radiation countermeasures as laser countermeasures and potential sensors has been investigated too. Radiation and laser attacks have similar effects on silicon devices. Whilst several countermeasures against radiation have been developed over the years, almost no explicit mention of laser countermeasures was found. This research has demonstrated the suitability of using some radiation countermeasures as laser countermeasures. Memory partitioning is a static and dynamic power consumption reduction technique successfully used in various devices. The nature of Smart Card devices restricts the applicability of some aspects of this power reduction technique. This research line has resulted in the proposal of a memory partitioning approach suitable to Smart Cards.

Published
2012

206. Gentamicin may have no effect on mortality of staphylococcal prosthetic valve endocarditis

Author

Sánchez, Fernando Fernández, Noureddine, Mariam, Rosas, Gabriel, Lima, Javier de la Torre, Aramendi, José, Bereciartua, Elena, Blanco, Roberto, Boado, María Victoria, Estébanez, Itxasne Cabezón, Lázaro, Marta Campaña, Goikoetxea, Josune, Goiti, Juan José, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodríguez, David, Rodríguez, Regino, Voces, Roberto, López, M<ce:sup loc='post">a</ce:sup> Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Yarza, Alberto Izaguirre, Urkola, Xabier Kortajarena, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Rey, Enrique Miguez, Mayo, María Rodríguez, Sánchez, Efrén, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, M<ce:sup loc='post">a</ce:sup>, Castro, Beatriz, Rosado, Dácil García, del Carmen Durán, M<ce:sup loc='post">a</ce:sup>, Antonia Miguel Gómez, M<ce:sup loc='post">a</ce:sup>, Lacalzada, Juan, Nassar, Ibrahim, Ciezar, Antonio Plata, Reguera Iglesias, José M<ce:sup loc='post">a</ce:sup>, Álvarez, Víctor Asensi, Costas, Carlos, Hera, Jesús de la, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Cruz, Ana Fernández, García Leoni, M<ce:sup loc='post">a</ce:sup> Eugenia, Ramallo, Víctor González, Hernández, Martha Kestler, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, M<ce:sup loc='post">a</ce:sup> Cruz, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, Antorrena, Isabel, Loeches, Belén, Quirós, Alejandro Martín, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Saldaña, Araceli, Balbín, Jesús Agüero, Castillo, Carlos Armiñanzas, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Izquierdo, Rubén Gómez, García, Iván, Rico, Claudia González, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Domínguez, Fernando, Pavíaz, Pablo García, Gonzálezz, Jesús, Ordenz, Beatriz, Ramosz, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, Río, Alejandro del, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, Uriarte, Oscar García, López, Alejandro Martín, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, Domínguez, Gloria García, Sánchez-Porto, Antonio, Arribas Leal, José M<ce:sup loc='post">a</ce:sup>, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, Valenzuela, Gonzalo de la Morena, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Rodríguez, Anai Moreno, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, M<ce:sup loc='post">a</ce:sup> Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Serrano, Pilar Egea, Hernández Roca, José Joaquín, Yañez, Ivan Keituqwa, Ballesta, Ana Peláez, Soriano, Víctor, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Pérez Seco, M<ce:sup loc='post">a</ce:sup> Cruz, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Palacián Ruiz, Ma Pilar, Porres, Juan Carlos, Ramos-Martínez, Antonio, Muñoz Serrano, Alejandro, de Alarcón González, Arístides, Fernández-Cruz, Ana, Miró, José M<ce:sup loc='post">a</ce:sup>, Ruiz-Morales, Josefa, Sousa-Regueiro, Dolores, Montejo, José Miguel, Gálvez-Acebal, Juan, and HidalgoTenorio, Carmen

Published
2018
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208. Propiedades Psicométricas de un Test de Comprensión Lectora para Alumnos de Educación Primaria

Author

Gema Pascual, Edurne Goikoetxea, and Héctor Bustos

Subjects
comprensión lectora, propiedades psicométricas, modelo de construcción-integración, procesos cognitivos, educación básica, Psychology, BF1-990
Abstract

Se presentan las propiedades psicométricas del test de Comprensión Lectora para Intervenir en Primaria (CLIP), desarrollado en base a modelos teóricos de los procesos cognitivos de la comprensión de textos (Kintsch, 1998). El objetivo del test es evaluar la comprensión lectora en estudiantes de primaria y arrojar información útil para planear la enseñanza que debe seguir a la evaluación. Con este propósito se usan diferentes textos (narrativos y expositivos, cortos y largos) y 3 tipos de preguntas (locales, globales e inferenciales), según la clasificación de Magliano et al. (2007), cuya respuesta debiera exigir al lector los procesos básicos de comprensión para construir el texto base y el modelo situacional. Por medio de un muestreo por conveniencia, participaron 1958 estudiantes de 3º a 6º de educación básica de 10 colegios particulares subvencionados y municipales de las comunas de Villarrica y Loncoche de la región de la Araucanía de Chile. El análisis de la consistencia interna (Kuder-Richardson 20) de las puntuaciones arroja valores iguales o superiores a 0,79. El análisis factorial confirmatorio halla evidencia de la presencia de 3 factores: Procesamiento Local, Procesamiento Global y Procesamiento Inferencial, cuando se analizan los resultados de los textos cortos. En los textos largos, el ajuste del modelo a los datos fue insatisfactorio. El análisis del funcionamiento diferencial de los ítems, según sexo y nivel socioeconómico, no reveló sesgo en ningún ítem del test.

Published
2021
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209. Formas y escalas emergentes de las democracias contemporáneas. Miradas desde la sociedad vasca

Author

López, Igor Filibi, San Epifanio, Leire Escajedo, Bilbao, Julen Zabalo, Escajedo, Leire, Filibi, Igor, Zabalo, Julen, Rojo, Argimiro, Martínez-Palacios, Jone, Gastón, Andere Ormazabal, Gurrutxaga, Igor Ahedo, López, Ainhoa Lasa, Telleria, Imanol, Lekue, Iago, Azkune, Jon, Romero, Eneko A., Goikoetxea, Jule, Calzada, Igor, Borja, Jordi, Uncetabarrenechea, Javier, Azkargorta, Leire, Landa, Xabier Albizu, Vázquez, Unai, Curto-López, Saúl, Pozas, Luis Miguel Uharte, Álvarez, Amalur, Vizán-Amorós, Ander, Larrinaga, Ane, Iraola, Iker, Amurrio, Mila, Odriozola, Onintza, Zubillaga-Herran, Nerea, Franco, Noemi Bergantiños, Elordui-Zapaterietxe, Arkaitz Fullaondo, Márquez, Gorka Moreno, Villasante, Tomás R., Berasaluze, Ainhoa, Epelde, Maddalen, Ariño, Miren, Ovejas, Charo, Ureta, Miriam, Goienetxea, Uxue Zugaza, Del Hoyo Moreno, Idoia, Martínez, Zesar, Gorostidi, Izaro, López, Igor Filibi, San Epifanio, Leire Escajedo, Bilbao, Julen Zabalo, Escajedo, Leire, Filibi, Igor, Zabalo, Julen, Rojo, Argimiro, Martínez-Palacios, Jone, Gastón, Andere Ormazabal, Gurrutxaga, Igor Ahedo, López, Ainhoa Lasa, Telleria, Imanol, Lekue, Iago, Azkune, Jon, Romero, Eneko A., Goikoetxea, Jule, Calzada, Igor, Borja, Jordi, Uncetabarrenechea, Javier, Azkargorta, Leire, Landa, Xabier Albizu, Vázquez, Unai, Curto-López, Saúl, Pozas, Luis Miguel Uharte, Álvarez, Amalur, Vizán-Amorós, Ander, Larrinaga, Ane, Iraola, Iker, Amurrio, Mila, Odriozola, Onintza, Zubillaga-Herran, Nerea, Franco, Noemi Bergantiños, Elordui-Zapaterietxe, Arkaitz Fullaondo, Márquez, Gorka Moreno, Villasante, Tomás R., Berasaluze, Ainhoa, Epelde, Maddalen, Ariño, Miren, Ovejas, Charo, Ureta, Miriam, Goienetxea, Uxue Zugaza, Del Hoyo Moreno, Idoia, Martínez, Zesar, and Gorostidi, Izaro

Published
2022

212. Molecular characterization of a suspected IMP-type carbapenemase-producing Pseudomonas aeruginosa outbreak reveals two simultaneous outbreaks in a tertiary-care hospital

Author

Ana Gual-de-Torrella, Carla López-Causape, Izaskun Alejo-Cancho, Estrella Rojo-Molinero, Gonzalo Sanchez-García, Sara Cortés-Lara, María B. Rodríguez Moral, Pilar Berdonces-Gonzalez, María J. Lopez de Goikoetxea, and Antonio Oliver

Subjects
Microbiology (medical), Infectious Diseases, Epidemiology
Abstract

Objective: To describe IMP-type carbapenemase-producing Pseudomonas aeruginosa outbreaks at Galdakao University Hospital between March 2021 to December 2021. Design: Outbreak report. Setting: Galdakao University Hospital is a tertiary-care hospital in the Basque Country (northern Spain). Patients: All patients with a positive IMP-type carbapenemase producing Pseudomonas aeruginosa (IMP-PA) culture were included in this study, both colonization and infection cases. Methods: An outbreak investigation was conducted, in which molecular epidemiology analysis [pulsed-field gel electrophoresis and whole-genome sequencing (WGS)] and environmental screenings were performed. Results: Between March and December 2021, 21 cases of IMP-PA were detected in Galdakao University Hospital: 18 infection cases and 3 colonization cases. In total, 4 different pulsotypes were detected belonging to 4 clones according to WGS: ST175 (n = 14), ST633 (n = 3), ST179 (n = 3), and ST348 (n = 1). IMP-13 was detected in most isolates belonging to the ST175 clone and in all ST179 and ST348 clones, whereas IMP-29 was detected in isolates belonging to the ST633 clone. Clinical isolates belonging to the ST175 clone were isolated mainly from patients admitted to the respiratory ward, and isolates belonging to the ST633 clone from patients admitted to the ICU. Two environmental isolates belonging to the ST175 clone were detected in the respiratory ward. Conclusions: Molecular and genomic epidemiology revealed that there had been 2 independent IMP-PA outbreaks, one of long duration in the respiratory ward and the other more limited in the ICU.

Published
2023
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213. Serum IFN-γ and RNAemia temporal profiles as biomarkers of severe COVID-19 in solid organ transplant and immunocompetent patients

Author

Sonsoles Salto-Alejandre, Marta Carretero-Ledesma, Pedro Camacho-Martínez, Judith Berastegui-Cabrera, Carmen Infante, Regino Rodríguez-Álvarez, Jorge Alba, Patricia Pérez-Palacios, Emilio García-Díaz, Cristina Roca, Julia Praena, María José Blanco-Vidal, Sonia Santibáñez, Rocío Valverde-Ortiz, Javier Nieto-Arana, Concepción García-García, David Gutiérrez-Campos, Natalia Maldonado, Gabriel Bernal, Miguel Ángel Gómez-Bravo, José Manuel Sobrino, Manuela Aguilar-Guisado, Rocío Álvarez-Marín, Josune Goikoetxea-Aguirre, José Antonio Oteo, Zaira R. Palacios-Baena, Álvaro Pascual, José Antonio Lepe, Jesús Rodríguez-Baño, José Miguel Cisneros, Jerónimo Pachón, Javier Sánchez-Céspedes, and Elisa Cordero

Subjects
Microbiology (medical), Infectious Diseases
Published
2023
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214. Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Author

María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos, Fisiologia, and Facultad de Veterinaria

Subjects
Hepatology, Nonalcoholic Steatohepatitis (NASH), 2411 Fisiología Humana, Fisiología, Mitochondrial dysfunction
Abstract

[EN] Background and Aims: Recent studies suggest that mitochondrial dysfunction promotes progression to NASH by aggravating the gut-liver status. However, the underlying mechanism remains unclear. Herein, we hypothesized that enhanced mitochondrial activity might reshape a specific microbiota signature that, when transferred to germ-free (GF) mice, could delay NASH progression. Approach and Results: Wild-type and methylation-controlled J protein knockout (MCJ-KO) mice were fed for 6 weeks with either control or a choline-deficient, L-amino acid–defined, high-fat diet (CDA-HFD). One mouse of each group acted as a donor of cecal microbiota to GF mice, who also underwent the CDA-HFD model for 3 weeks. Hepatic injury, intestinal barrier, gut microbiome, and the associated fecal metabolome were then studied. Following 6 weeks of CDA-HFD, the absence of methylation-controlled J protein, an inhibitor of mitochondrial complex I activity, reduced hepatic injury and improved gut-liver axis in an aggressive NASH dietary model. This effect was transferred to GF mice through cecal microbiota transplantation. We suggest that the specific microbiota profile of MCJ-KO, characterized by an increase in the fecal relative abundance of Dorea and Oscillospira genera and a reduction in AF12, Allboaculum, and [Ruminococcus], exerted protective actions through enhancing short-chain fatty acids, nicotinamide adenine dinucleotide (NAD+) metabolism, and sirtuin activity, subsequently increasing fatty acid oxidation in GF mice. Importantly, we identified Dorea genus as one of the main modulators of this microbiota-dependent protective phenotype. Conclusions: Overall, we provide evidence for the relevance of mitochondria–microbiota interplay during NASH and that targeting it could be a valuable therapeutic approach. SI Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE

Published
2023
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217. An in vitro ovarian explant culture system to examine sex change in a hermaphroditic fish

Author

Alexander Goikoetxea, Erin L. Damsteegt, Erica V. Todd, Andrew McNaughton, Neil J. Gemmell, and P. Mark Lokman

Subjects
Organ culture, Sex change, Previtellogenic oocyte, Cortisol, Spotty wrasse, Medicine, Biology (General), QH301-705.5
Abstract

Many teleost fishes undergo natural sex change, and elucidating the physiological and molecular controls of this process offers unique opportunities not only to develop methods of controlling sex in aquaculture settings, but to better understand vertebrate sexual development more broadly. Induction of sex change in some sequentially hermaphroditic or gonochoristic fish can be achieved in vivo through social manipulation, inhibition of aromatase activity, or steroid treatment. However, the induction of sex change in vitro has been largely unexplored. In this study, we established an in vitro culture system for ovarian explants in serum-free medium for a model sequential hermaphrodite, the New Zealand spotty wrasse (Notolabrus celidotus). This culture technique enabled evaluating the effect of various treatments with 17β-estradiol (E2), 11-ketotestosterone (11KT) or cortisol (CORT) on spotty wrasse ovarian architecture for 21 days. A quantitative approach to measuring the degree of ovarian atresia within histological images was also developed, using pixel-based machine learning software. Ovarian atresia likely due to culture was observed across all treatments including no-hormone controls, but was minimised with treatment of at least 10 ng/mL E2. Neither 11KT nor CORT administration induced proliferation of spermatogonia (i.e., sex change) in the cultured ovaries indicating culture beyond 21 days may be needed to induce sex change in vitro. The in vitro gonadal culture and analysis systems established here enable future studies investigating the paracrine role of sex steroids, glucocorticoids and a variety of other factors during gonadal sex change in fish.

Published
2020
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218. Diseño del área quirúrgica para experimentación animal; cinco casos de estudio

Author

Aitziber Goikoetxea Ibarrondo, Pedro Berroya Ortiz de Urbina, Mercedes Valiente López, and Francisco Domouso de Alba

Subjects
experimentación animal grande, cirugía experimental, diseño de quirófanos experimentales, prácticas quirúrgicas, investigación biomédica, Architecture, NA1-9428, Building construction, TH1-9745
Abstract

Las unidades de cirugía para experimentación animal son instalaciones complejas de planificar y diseñar. Es por ello que para afrontar un proyecto de este tipo resulta recomendable visitar o recopilar la información que se encuentra disponible sobre unidades similares ya construidas, para así poder analizar los diferentes modelos conceptuales y los flujos de trabajo que puedan servir de referencia. En este trabajo, a través de expresiones gráficas, se estudia el modelo organizativo, diseño conceptual y características constructivas de las unidades quirúrgicas experimentales de cinco Institutos de Investigación Sanitaria Acreditados por el Instituto de Salud Carlos III. A partir de la puesta en común de los resultados obtenidos del análisis de varios centros se pretende establecer unas pautas de comportamiento o protocolos que puedan ser de utilidad a los profesionales responsables del diseño, construcción y puesta en funcionamiento de nuevos quirófanos experimentales.

Published
2020
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219. Morfología de la lavandera cascadeña Motacilla cinerea L., 1758 en Gipuzkoa (región cantábrica).

Author

Nerea Pagaldai, José I. Jauregi, Irati Zubia, Iñaki Aranguren, Javier Goikoetxea, José M. Sánchez, and Juan Arizaga

Subjects
anillamiento, biometría, aves, edad, ríos, sexo., ringing, biometrics, birds, age, rivers, sex., Science
Abstract

El objetivo de este artículo es describir la morfología de la lavandera cascadeña Motacilla cinerea L., 1758 (y en particular su variación según sexos y clases de edad) en Gipuzkoa. Además, y dado que en las aves de primer año no es posible conocer el sexo a partir de la coloración, se realiza un Análisis Discriminante (AD) con el fin de ofrecer una fórmula biométrica para la diferenciación de sexos en aves no adultas. La morfología de la lavandera cascadeña en el área de estudio varía tanto entre sexos como entre edades. El sexo tuvo un efecto más fuerte que la edad, al influir en cuatro variables (longitud alar, apuntamiento del ala, longitud de la cola y cráneo+pico) frente a las tres de la edad (las cuatro de antes menos el apuntamiento del ala). Solamente el tarso no varió ni entre sexos ni entre edades. En general, los valores más bajos se hallaron en hembras jóvenes y, los más altos, en machos adultos. El análisis discriminante proporcionó una fórmula que sólo clasificó bien el sexo en el 69% de la muestra de jóvenes lavanderas cascadeñas. Esto es debido a la existencia de un alto solapamiento biométrico entre los sexos, dentro de esta edad, lo que en la práctica supone la no recomendación del uso de la ecuación dada su baja fiabilidad. _________________________________________ The aim of this study was to describe the morphology of a population of grey wagtails Motacilla cinerea L., 1758, breeding in Gipuzkoa (Spain). Additionally, due to the difficulty involved in sexing first-year birds based on their colouration, we carried out Discriminant Analysis (DA) to find an equation that would allow us to determine the sex of individuals using their morphological data. The morphology varied both between ages and sexes. Sex had a greater effect than age, as it varied in four variables (wing length, wing pointedness, tail length, head+bill length), whilst age only varied in three of these variables (all the aforementioned, except wing pointedness). Overall, the lowest values were found in young females, whereas the highest ones were typical of adult males. The DA provided an equation that enabled us to classify correctly only 69% of the sample and, therefore, its application for the reliable sexing of young birds in the field is not recommended.

Published
2020

220. Bartonella Endocarditis in Spain: Case Reports of 21 Cases

Author

Lara García-Álvarez, Concepción García-García, Patricia Muñoz, María del Carmen Fariñas-Álvarez, Manuel Gutiérrez Cuadra, Nuria Fernández-Hidalgo, Elisa García-Vázquez, Encarnación Moral-Escudero, María del Mar Alonso-Socas, Dácil García-Rosado, Carmen Hidalgo-Tenorio, Fernando Domínguez, Josune Goikoetxea-Agirre, Juan Carlos Gainzarain, María Ángeles Rodríguez-Esteban, Xerach Bosch-Guerra, José A. Oteo, and On behalf of Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)

Subjects
infective endocarditis, blood culture negative endocarditis, Bartonella endocarditis, Bartonella spp., Medicine
Abstract

Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the “Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)”cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment.

Published
2022
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221. Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development—Results from the PRO-BAC Cohort

Author

Pedro María Martínez Pérez-Crespo, Álvaro Rojas, Joaquín Felipe Lanz-García, Pilar Retamar-Gentil, José María Reguera-Iglesias, Olalla Lima-Rodríguez, Alfonso del Arco Jiménez, Jonathan Fernández Suárez, Alfredo Jover-Saenz, Josune Goikoetxea Aguirre, Eva León Jiménez, María Luisa Cantón-Bulnes, Pilar Ortega Lafont, Carlos Armiñanzas Castillo, Juan Sevilla Blanco, Jordi Cuquet Pedragosa, Lucía Boix-Palop, Berta Becerril Carral, Alberto Bahamonde-Carrasco, Teresa Marrodan Ciordia, Clara Natera Kindelán, Isabel María Reche Molina, Carmen Herrero Rodríguez, Inés Pérez Camacho, David Vinuesa García, Fátima Galán-Sánchez, Alejandro Smithson Amat, Esperanza Merino de Lucas, Antonio Sánchez-Porto, Marcos Guzmán García, Inmaculada López-Hernández, Jesús Rodríguez-Baño, Luis Eduardo López-Cortés, and on behalf of the PROBAC REIPI/GEIH-SEIMC/SAEI Group

Subjects
Pseudomonas aeruginosa, bacteraemia, bloodstream infection, community-onset, epidemiology, Therapeutics. Pharmacology, RM1-950
Abstract

Community-onset bloodstream infections (CO-BSI) caused by gram-negative bacilli are common and associated with significant mortality; those caused by Pseudomonas aeruginosa are associated with worse prognosis and higher rates of inadequateempirical antibiotic treatment. The aims of this study were to describe the characteristics of patients with CO-BSI caused by P. aeruginosa, to identify predictors, and to develop a predictive score for P. aeruginosa CO-BSI. Materials/methods: PROBAC is a prospective cohort including patients >14 years with BSI from 26 Spanish hospitals between October 2016 and May 2017. Patients with monomicrobial P. aeruginosa CO-BSI and monomicrobial Enterobacterales CO-BSI were included. Variables of interest were collected. Independent predictors of Pseudomonas aeruginosa CO-BSI were identified by logistic regression and a prediction score was developed. Results: A total of 78patients with P. aeruginosa CO-BSI and 2572 with Enterobacterales CO-BSI were included. Patients with P. aeruginosa had a median age of 70 years (IQR 60–79), 68.8% were male, median Charlson score was 5 (IQR 3–7), and 30-daymortality was 18.5%. Multivariate analysis identified the following predictors of CO-BSI-PA [adjusted OR (95% CI)]: male gender [1.89 (1.14–3.12)], haematological malignancy [2.45 (1.20–4.99)], obstructive uropathy [2.86 (1.13–3.02)], source of infection other than urinary tract, biliary tract or intra-abdominal [6.69 (4.10–10.92)] and healthcare-associated BSI [1.85 (1.13–3.02)]. Anindex predictive of CO-BSI-PA was developed; scores ≥ 3.5 showed a negative predictive value of 89% and an area under the receiver operator curve (ROC) of 0.66. Conclusions: We did not find a good predictive score of P. aeruginosa CO-BSI due to its relatively low incidence in the overall population. Our model includes variables that are easy to collect in real clinical practice and could be useful to detect patients with very low risk of P. aeruginosa CO-BSI.

Published
2022
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222. Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Author

Rubén Rodríguez-Agudo, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Pablo Fernández-Tussy, David Fernández-Ramos, Sofía Lachiondo-Ortega, Irene González-Recio, Clàudia Gil-Pitarch, María Mercado-Gómez, Laura Morán, Maider Bizkarguenaga, Fernando Lopitz-Otsoa, Petar Petrov, Miren Bravo, Sebastiaan Martijn Van Liempd, Juan Manuel Falcon-Perez, Amaia Zabala-Letona, Arkaitz Carracedo, Jose Vicente Castell, Ramiro Jover, Luis Alfonso Martínez-Cruz, Teresa Cardoso Delgado, Francisco Javier Cubero, María Isabel Lucena, Raúl Jesús Andrade, Jon Mabe, Jorge Simón, and María Luz Martínez-Chantar

Subjects
drug-induced liver injury (DILI), acetaminophen (APAP), ammonia, methionine cycle, miR-873-5p, therapy, Therapeutics. Pharmacology, RM1-950
Abstract

Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered 8 h after overdose to be efficient. Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GNMT) expression and S-adenosylmethionine (AdoMet) levels that suggest a reduced methionine cycle. Anti-miR-873-5p treatment prevents cell death in primary hepatocytes and the appearance of necrotic areas in liver from APAP-administered mice. In our study, we demonstrate a GNMT and methionine cycle activity restoration by the anti-miR-873-5p that reduces mitochondrial dysfunction and oxidative stress. The lack of hyperammoniemia caused by the therapy results in a decreased urea cycle, enhancing the synthesis of polyamines from ornithine and AdoMet and thus impacting the observed recovery of mitochondria and hepatocyte proliferation for regeneration. In summary, anti-miR-873-5p appears to be an effective therapy against APAP-induced liver injury, where the restoration of GNMT and the methionine cycle may prevent mitochondrial dysfunction while activating hepatocyte proliferative response.

Published
2022
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229. HTLV-1-associated myelopathy in Spain

Author

de-Mendoza, Carmen, primary, Pérez, Leire, additional, Rando, Ariadna, additional, Reina, Gabriel, additional, Aguilera, Antonio, additional, Benito, Rafael, additional, Eirós, José María, additional, Rodríguez-Avial, Itziar, additional, Roc, Lourdes, additional, Pozuelo, María José, additional, Pena, María José, additional, Soriano, Vicente, additional, Calderón, E., additional, Rodríguez-Iglesias, M., additional, Montiel, N., additional, Trujillo, T., additional, Viciana, I., additional, Cabezas, T., additional, Lozano, A., additional, Fernández-Fuertes, E., additional, Fernández, J.M., additional, García, F., additional, Benito, R., additional, Algarate, S., additional, Ducons, M., additional, Roc, L., additional, Cifuentes, C., additional, Fernández-Baca, V., additional, Fernández-Montero, J.V, additional, Maciá, MD., additional, Hernández-Betancor, A., additional, Martín, A.M., additional, Pena, M.J., additional, Hernández, M., additional, López-Lirola, A.M., additional, Gómez-Sirvent, J.L., additional, Copado, R., additional, Cano, M.E., additional, Rojo, S., additional, Eirós, J.M., additional, Rodríguez, M., additional, Gómez-Hernando, C., additional, González-Praetorius, A., additional, Rando, A., additional, Force, L., additional, Miró, E., additional, Cebollero, A., additional, Delgado, J.F., additional, Rodríguez, G., additional, Fernández-Pereira, L., additional, Aguilera, A., additional, Pereira, S., additional, García, J., additional, Trigo, M., additional, Diz, J., additional, García-Campello, M., additional, Cortizo, S., additional, Pérez, S., additional, Morano, L., additional, Reina, G., additional, Arazamendi, M., additional, Salicio, Y., additional, Ugalde, E., additional, Nieto, M.C., additional, Liendo, P., additional, Goikoetxea, A.J., additional, Ocete, M.D., additional, Ramos, J.M., additional, Escribano, I., additional, Sauleda, S., additional, Pirón, M., additional, González, R., additional, Richart, A., additional, Barea, L., additional, Jiménez, A., additional, Blanco, L., additional, Navarro, L., additional, Ayerdi, O., additional, Baza, B., additional, Rodriguez, C., additional, del-Romero, J., additional, Galar, A., additional, Aldamiz, T., additional, Valeiro, M., additional, Pérez, L., additional, Rodríguez-Avial, I., additional, Martín-Carbonero, L., additional, Barreiro, P., additional, Fernández-Ruiz, M., additional, Parra, P., additional, Redondo, N., additional, Ruiz-Merlo, T., additional, Pozuelo, M.J., additional, Treviño, A., additional, Corral, O., additional, Soriano, V., additional, Pintos, I., additional, Moreno-Torres, V., additional, Carrizo, P., additional, Huertas, A., additional, Vargas-Núñez, J.A., additional, and de-Mendoza, C., additional

Published
2023
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231. HTLV-1 infection among Latin American pregnant women living in Spain

Author

Encinas, Begoña, primary, Benito, Rafael, additional, Rojo, Silvia, additional, Reina, Gabriel, additional, Montiel, Natalia, additional, Aguilera, Antonio, additional, Eiros, José María, additional, García-Costa, Juan, additional, Ortega, Diego, additional, Soriano, Vicente, additional, de-Mendoza, Carmen, additional, Calderón, E., additional, Rodríguez-Iglesias, M., additional, Montiel, N., additional, Trujillo, T., additional, Viciana, Cádiz I., additional, Cabezas, Málaga T., additional, Lozano, Almería A., additional, Fernández-Fuertes, E., additional, Fernández, J.M., additional, García, F., additional, Benito, R., additional, Algarate, S., additional, Ducons, M., additional, Roc, L., additional, Cifuentes, C., additional, Fernández-Baca, V., additional, Fernández-Montero, J.V, additional, Maciá, M.D., additional, Hernández-Betancor, A., additional, Martín, A.M., additional, Pena, M.J., additional, Hernández, M., additional, López-Lirola, A.M., additional, Gómez-Sirvent, J.L., additional, Copado, R., additional, Cano, M.E., additional, Rojo, S., additional, Eirós, J.M., additional, Rodríguez, M., additional, Gómez-Hernando, C., additional, González-Praetorius, A., additional, Rando, A., additional, Force, L., additional, Miró, E., additional, Cebollero, A., additional, Delgado, J.F., additional, Rodríguez, G., additional, Fernández-Pereira, L., additional, Aguilera, A., additional, Pereira, S., additional, García, J., additional, Trigo, M., additional, Diz, J., additional, García-Campello, M., additional, Cortizo, S., additional, Pérez, S., additional, Morano, L., additional, Reina, G., additional, Arazamendi, M., additional, Salicio, Y., additional, Ugalde, E., additional, Nieto, M.C., additional, Liendo, P., additional, Goikoetxea, A.J., additional, Ocete, M.D., additional, Ramos, J.M., additional, Escribano, I., additional, Sauleda, S., additional, Pirón, M., additional, González, R., additional, Richart, A., additional, Barea, L., additional, Jiménez, A., additional, Blanco, L., additional, Navarro, L., additional, Ayerdi, O., additional, Baza, B., additional, Rodriguez, C., additional, del-Romero, J., additional, Galar, A., additional, Aldamiz, T., additional, Valeiro, M., additional, Pérez, L., additional, Rodríguez-Avial, I., additional, Martín-Carbonero, L., additional, Fernández-Ruiz, M., additional, Parra, P., additional, Redondo, N., additional, Ruiz-Merlo, T., additional, Pozuelo, M.J., additional, Barreiro, P., additional, Treviño, A., additional, de-Jesús, F., additional, Corral, O., additional, Soriano, V., additional, Pintos, I., additional, Moreno-Torres, V., additional, Carrizo, P., additional, Huertas, A., additional, Vargas-Núñez, J.A., additional, and de-Mendoza, C., additional

Published
2023
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233. Adult T-cell leukemia/lymphoma in HTLV-1 non-endemic regions

Author

de Mendoza, Carmen, primary, Rando, Ariadna, additional, Miró, Elisenda, additional, Pena, María José, additional, Rodríguez-Avial, Iciar, additional, Ortega, Diego, additional, González-Praetorius, Alejandro, additional, Reina, Gabriel, additional, Pintos, Ilduara, additional, Pozuelo, María José, additional, Soriano, Vicente, additional, Calderón, E., additional, Rodríguez-Iglesias, M., additional, Montiel, N., additional, Trujillo, T., additional, Viciana, I., additional, Cabezas, T., additional, Lozano, A., additional, Fernández-Fuertes, E., additional, Fernández, J.M., additional, García, F., additional, Benito, R., additional, Algarate, S., additional, Ducons, M., additional, Roc, L., additional, Cifuentes, C., additional, Fernández-Baca, V., additional, Fernández-Montero, J.V, additional, Maciá, MD., additional, Hernández-Betancor, A., additional, Martín, A.M., additional, Pena, M.J., additional, Hernández, M., additional, López-Lirola, A.M., additional, Gómez-Sirvent, J.L., additional, Copado, R., additional, Cano, M.E., additional, Rojo, S., additional, Eirós, J.M., additional, Rodríguez, M., additional, Gómez-Hernando, C., additional, González-Praetorius, A., additional, Rando, A., additional, Force, L., additional, Miró, E., additional, Cebollero, A., additional, Delgado, J.F., additional, Rodríguez, G., additional, Fernández-Pereira, L., additional, Aguilera, A., additional, Pereira, S., additional, García, J., additional, Trigo, M., additional, Diz, J., additional, García-Campello, M., additional, Cortizo, S., additional, Pérez, S., additional, Morano, L., additional, Reina, G., additional, Arazamendi, M., additional, Salicio, Y., additional, Ugalde, E., additional, Nieto, M.C., additional, Liendo, P., additional, Goikoetxea, A.J., additional, Ocete, M.D., additional, Ramos, J.M., additional, Escribano, I., additional, Sauleda, S., additional, Pirón, M., additional, González, R., additional, Richart, A., additional, Barea, L., additional, Jiménez, A., additional, Blanco, L., additional, Navarro, L., additional, Ayerdi, O., additional, Baza, B., additional, Rodriguez, C., additional, del Romero, J., additional, Galar, A., additional, Aldamiz, T., additional, Valeiro, M., additional, Pérez, L., additional, Rodríguez-Avial, I., additional, Martín-Carbonero, L., additional, Fernández-Ruiz, M., additional, Parra, P., additional, Redondo, N., additional, Ruiz-Merlo, T., additional, Pozuelo, M.J., additional, Barreiro, P., additional, Treviño, A., additional, Corral, O., additional, Soriano, V., additional, Pintos, I., additional, Moreno-Torres, V., additional, Carrizo, P., additional, Huertas, A., additional, Vargas-Núñez, J.A., additional, and de Mendoza, C., additional

Published
2023
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235. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

Author

Pittet, Laure F., primary, Moore, Cecilia L., additional, McDonald, Ellie, additional, Barry, Simone, additional, Bonten, Marc, additional, Campbell, John, additional, Croda, Julio, additional, Dalcolmo, Margareth, additional, Davidson, Andrew, additional, Douglas, Mark W., additional, Gardiner, Kaya, additional, Gwee, Amanda, additional, Jardim, Bruno, additional, Lacerda, Marcus V.G., additional, Lucas, Michaela, additional, Lynn, David J., additional, Manning, Laurens, additional, de Oliveira, Roberto D., additional, Perrett, Kirsten P., additional, Prat-Aymerich, Cristina, additional, Richmond, Peter C., additional, Rocha, Jorge L., additional, Rodriguez-Baño, Jesus, additional, Warris, Adilia, additional, Wood, Nicholas J., additional, Messina, Nicole L., additional, Curtis, Nigel, additional, Jamieson, Tenaya, additional, Messina, Nicole, additional, Morawakage, Thilanka, additional, Perlen, Susan, additional, Perrett, Kirsten, additional, Pittet, Laure, additional, Sastry, Amber, additional, Teo, Jia Wei, additional, Orsini, Francesca, additional, Lee, Katherine, additional, Moore, Cecilia, additional, Vidmar, Suzanna, additional, Ali, Rashida, additional, Dunn, Ross, additional, Edler, Peta, additional, Gell, Grace, additional, Goodall, Casey, additional, Hall, Richard, additional, Krastev, Ann, additional, La, Nathan, additional, McPhate, Nick, additional, Nguyen, Thao, additional, Ren, Jack, additional, Stevens, Luke, additional, Alamrousi, Ahmed, additional, Bonnici, Rhian, additional, Dang, Thanh, additional, Germano, Susie, additional, Hua, Jenny, additional, McElroy, Rebecca, additional, Razmovska, Monica, additional, Reddiex, Scott, additional, Wang, Xiaofang, additional, Anderson, Jeremy, additional, Azzopardi, Kristy, additional, Bennett-Wood, Vicki, additional, Czajko, Anna, additional, Mazarakis, Nadia, additional, McCafferty, Conor, additional, Oppedisano, Frances, additional, Ortika, Belinda, additional, Pell, Casey, additional, Spry, Leena, additional, Toh, Ryan, additional, Velagapudi, Sunitha, additional, Vlahos, Amanda, additional, Wee-Hee, Ashleigh, additional, Ramos, Pedro, additional, De La Cruz, Karina, additional, Gamage, Dinusha, additional, Karunanayake, Anushka, additional, Mezzetti, Isabella, additional, Ong, Benjamin, additional, Singh, Ronita, additional, Sooriyarachchi, Enoshini, additional, Nicholson, Suellen, additional, Cain, Natalie, additional, Brizuela, Rianne, additional, Huang, Han, additional, Abruzzo, Veronica, additional, Bealing, Morgan, additional, Bimboese, Patricia, additional, Bowes, Kirsty, additional, Burrell, Emma, additional, Chan, Joyce, additional, Cushnahan, Jac, additional, Elborough, Hannah, additional, Elkington, Olivia, additional, Fahey, Kieran, additional, Fernandez, Monique, additional, Flynn, Catherine, additional, Fowler, Sarah, additional, Andrit, Marie Gentile, additional, Gladanac, Bojana, additional, Hammond, Catherine, additional, Ma, Norine, additional, Macalister, Sam, additional, Milojevic, Emmah, additional, Mojeed, Jesutofunmi, additional, Nguyen, Jill, additional, O'Donnell, Liz, additional, Olivier, Nadia, additional, Ooi, Isabelle, additional, Reynolds, Stephanie, additional, Shen, Lisa, additional, Sherry, Barb, additional, Spotswood, Judith, additional, Wedderburn, Jamie, additional, Younes, Angela, additional, Legge, Donna, additional, Bell, Jason, additional, Cheah, Jo, additional, Cobbledick, Annie, additional, Lim, Kee, additional, Elia, Sonja, additional, Addlem, Lynne, additional, Bourke, Anna, additional, Brophy, Clare, additional, Henare, Nadine, additional, Jenkins, Narelle, additional, Machingaifa, Francesca, additional, Miller, Skye, additional, Mitchell, Kirsten, additional, Pitkin, Sigrid, additional, Wall, Kate, additional, Villanueva, Paola, additional, Crawford, Nigel, additional, Norton, Wendy, additional, Tan, Niki, additional, Chengodu, Thilakavathi, additional, Dawson, Diane, additional, Gordon, Victoria, additional, Korman, Tony, additional, O'Bryan, Jess, additional, Agius, Sophie, additional, Bannister, Samantha, additional, Bucholc, Jess, additional, Burns, Alison, additional, Camesella, Beatriz, additional, Carlin, John, additional, Ciaverella, Marianna, additional, Curtis, Maxwell, additional, Firth, Stephanie, additional, Guo, Christina, additional, Hannan, Matthew, additional, Hill, Erin, additional, Joshi, Sri, additional, Lieschke, Katherine, additional, Mathers, Megan, additional, Odoi, Sasha, additional, Rak, Ashleigh, additional, Richards, Chris, additional, Steve, Leah, additional, Stewart, Carolyn, additional, Sudbury, Eva, additional, Thomson, Helen, additional, Watts, Emma, additional, Williams, Fiona, additional, Young, Angela, additional, Glenn, Penny, additional, Kaynes, Andrew, additional, Philippart De Floy, Amandine, additional, Buchanan, Sandy, additional, Sondag, Thijs, additional, Xie, Ivy, additional, Edmund, Harriet, additional, Byrne, Bridie, additional, Keeble, Tom, additional, Ngien, Belle, additional, Noonan, Fran, additional, Wearing-Smith, Michelle, additional, Clarke, Alison, additional, Davies, Pemma, additional, Eastwood, Oliver, additional, Ellinghaus, Alric, additional, Ghieh, Rachid, additional, Hilton, Zahra, additional, Jennings, Emma, additional, Kakkos, Athina, additional, Liang, Iris, additional, Nicol, Katie, additional, O'Callaghan, Sally, additional, Osman, Helen, additional, Rajaram, Gowri, additional, Ratcliffe, Sophia, additional, Rayner, Victoria, additional, Salmon, Ashleigh, additional, Scheppokat, Angela, additional, Stevens, Aimee, additional, Street, Rebekah, additional, Toogood, Nicholas, additional, Wood, Nicholas, additional, Bahaduri, Twinkle, additional, Baulman, Therese, additional, Byrne, Jennifer, additional, Carter, Candace, additional, Corbett, Mary, additional, Dao, Aiken, additional, Desylva, Maria, additional, Dunn, Andrew, additional, Gardiner, Evangeline, additional, Joyce, Rosemary, additional, Kandasamy, Rama, additional, Munns, Craig, additional, Pelayo, Lisa, additional, Sharma, Ketaki, additional, Sterling, Katrina, additional, Uren, Caitlin, additional, Colaco, Clinton, additional, Douglas, Mark, additional, Hamilton, Kate, additional, Bartlett, Adam, additional, McMullan, Brendan, additional, Palasanthiran, Pamela, additional, Williams, Phoebe, additional, Beardsley, Justin, additional, Bergant, Nikki, additional, Lagunday, Renier, additional, Overton, Kristen, additional, Post, Jeffrey, additional, Al-Hindawi, Yasmeen, additional, Barney, Sarah, additional, Byrne, Anthony, additional, Mead, Lee, additional, Plit, Marshall, additional, Lynn, David, additional, Benson, Saoirse, additional, Blake, Stephen, additional, Botten, Rochelle, additional, Chern, Tee Yee, additional, Eden, Georgina, additional, Griffith, Liddy, additional, James, Jane, additional, Lynn, Miriam, additional, Markow, Angela, additional, Sacca, Domenic, additional, Stevens, Natalie, additional, Wesselingh, Steve, additional, Doran, Catriona, additional, Sawka, Alice, additional, Evans, Sue, additional, Goodchild, Louise, additional, Heath, Christine, additional, Krieg, Meredith, additional, Marshall, Helen, additional, McMillan, Mark, additional, Walker, Mary, additional, Richmond, Peter, additional, Amenyogbe, Nelly, additional, Anthony, Christina, additional, Arnold, Annabelle, additional, Arrowsmith, Beth, additional, Ben-Othman, Rym, additional, Clark, Sharon, additional, Dunnill, Jemma, additional, Eiffler, Nat, additional, Ewe, Krist, additional, Finucane, Carolyn, additional, Flynn, Lorraine, additional, Gibson, Camille, additional, Hartnell, Lucy, additional, Hollams, Elysia, additional, Hutton, Heidi, additional, Jarvis, Lance, additional, Jones, Jane, additional, Jones, Jan, additional, Jones, Karen, additional, Kent, Jennifer, additional, Kollmann, Tobias, additional, Lalich, Debbie, additional, Lee, Wenna, additional, Lim, Rachel, additional, McAlister, Sonia, additional, McDonald, Fiona, additional, Meehan, Andrea, additional, Minhaj, Asma, additional, Montgomery, Lisa, additional, O'Donnell, Melissa, additional, Ong, Jaslyn, additional, Ong, Joanne, additional, Parkin, Kimberley, additional, Perez, Glady, additional, Power, Catherine, additional, Rezazadeh, Shadie, additional, Richmond, Holly, additional, Rogers, Sally, additional, Schultz, Nikki, additional, Shave, Margaret, additional, Skut, Patrycja, additional, Stiglmayer, Lisa, additional, Truelove, Alexandra, additional, Wadia, Ushma, additional, Wallace, Rachael, additional, Waring, Justin, additional, England, Michelle, additional, Latkovic, Erin, additional, Herrmann, Susan, additional, Lacerda, Marcus, additional, Andrade, Paulo Henrique, additional, Barbosa, Fabiane Bianca, additional, Barros, Dayanne, additional, Brasil, Larissa, additional, Capella, Ana Greyce, additional, Castro, Ramon, additional, Costa, Erlane, additional, de Souza, Dilcimar, additional, Dias, Maianne, additional, Dias, José, additional, Ferreira, Klenilson, additional, Figueiredo, Paula, additional, Freitas, Thamires, additional, Furtado, Ana Carolina, additional, Gama, Larissa, additional, Godinho, Vanessa, additional, Gouy, Cintia, additional, Hinojosa, Daniele, additional, Jardim, Tyane, additional, Junior, Joel, additional, Lima, Augustto, additional, Maia, Bernardo, additional, Marins, Adriana, additional, Mazurega, Kelry, additional, Medeiros, Tercilene, additional, Melo, Rosangela, additional, Moraes, Marinete, additional, Nascimento, Elizandra, additional, Neves, Juliana, additional, Oliveira, Maria Gabriela, additional, Oliveira, Thais, additional, Oliveira, Ingrid, additional, Otsuka, Arthur, additional, Paes, Rayssa, additional, Pereira, Handerson, additional, Pereira, Gabrielle, additional, Prado, Christiane, additional, Queiroz, Evelyn, additional, Rodrigues, Laleyska, additional, Rodrigues, Bebeto, additional, Sampaio, Vanderson, additional, Santos, Anna Gabriela, additional, Santos, Daniel, additional, Santos, Tilza, additional, Santos, Evelyn, additional, Sartim, Ariandra, additional, Silva, Ana Beatriz, additional, Silva, Juliana, additional, Silva, Emanuelle, additional, Simão, Mariana, additional, Soares, Caroline, additional, Sousa, Antonny, additional, Trindade, Alexandre, additional, Val, Fernando, additional, Vasconcelos, Adria, additional, Vasconcelos, Heline, additional, Abreu, Carolinne, additional, Almeida, Katya Martinez, additional, Bitencourt de Andrade, Camila, additional, Campos Angelo, Jhenyfer Thalyta, additional, Gonçalvez de Araújo Arcanjo, Ghislaine, additional, Silva Menezes Arruda, Bianca Maria, additional, Ayala, Wellyngthon Espindola, additional, Refosco Barbosa, Adelita Agripina, additional, Vieira Batista, Felipe Zampieri, additional, de Morais Batista, Fabiani, additional, de Jesus Costa, Miriam, additional, Croda, Mariana Garcia, additional, Alves da Cruz, Lais, additional, Pereira Diogo, Roberta Carolina, additional, Dutra Escobar, Rodrigo Cezar, additional, Fernandes, Iara Rodrigues, additional, Figueiredo, Leticia Ramires, additional, Cavalcanti Gonçalves, Leandro Galdino, additional, Lahdo, Sarita, additional, Lencina, Joyce dos Santos, additional, Teodoro de Lima, Guilherme, additional, Matos, Larissa Santos, additional, Leopoldina Meireles, Bruna Tayara, additional, Moreira, Debora Quadros, additional, Silva Muranaka, Lilian Batista, additional, de Oliveira, Adriely, additional, Warszawski de Oliveira, Karla Regina, additional, Vieira de Oliveira, Matheus, additional, Dias de Oliveira, Roberto, additional, Souza de Almeida dos Reis Pereira, Andrea Antonia, additional, Puga, Marco, additional, Ramos, Caroliny Veron, additional, Souza da Rosa, Thaynara Haynara, additional, Lopes dos Santos, Karla, additional, Ribeiro dos Santos, Claudinalva, additional, Leopoldina dos Santos, Dyenyffer Stéffany, additional, Santos, Karina Marques, additional, Pereira da Silva, Paulo César, additional, Rocha da Silva, Paulo Victor, additional, Silva, Débora dos Santos, additional, Vieira da Silva, Patricia, additional, Freitas da Rosa Soares, Bruno, additional, Sperotto, Mariana Gazzoni, additional, Tadokoro, Mariana Mayumi, additional, Tsuha, Daniel, additional, Ramos Vieira, Hugo Miguel, additional, Pretti Dalcolmo, Margareth Maria, additional, Lopes Alves da Paixão, Cíntia Maria, additional, Corrêa E Castro, Gabriela, additional, Collopy, Simone Silva, additional, da Costa Silva, Renato, additional, Almeida da Silveira, Samyra, additional, Da-Cruz, Alda Maria, additional, Maria da Silva Passos de Carvalho, Alessandra, additional, de Cássia Batista, Rita, additional, Silva De Freitas, Maria Luciana, additional, Gerhardt de Oliveira Ferreira, Aline, additional, Conceição de Souza, Ana Paula, additional, Doblas, Paola Cerbino, additional, Alcoforado da Silva dos Santos, Ayla, additional, Cristine de Moraes dos Santos, Vanessa, additional, Alves dos Santos Gomes, Dayane, additional, Fortunato, Anderson Lage, additional, Gomes-Silva, Adriano, additional, Gonçalves, Monique Pinto, additional, Garcia Meireless Junior, Paulo Leandro, additional, Martins da Costa Carvalho, Estela, additional, Motta, Fernando do Couto, additional, Olivo de Mendonça, Ligia Maria, additional, Pandine, Girlene dos Santos, additional, Plácido Pereira, Rosa Maria, additional, Maia, Ivan Ramos, additional, Luiz da Rocha, Jorge, additional, Paiva Romano, João Victor, additional, Santos, Glauce dos, additional, Fernandes da Silva, Erica, additional, Mendonça Teixeira de Siqueira, Marilda Agudo, additional, Prudêncio Soares, Ágatha Cristinne, additional, Arroyo, Sandra Franch, additional, Besten, Henny Ophorst-den, additional, Boon, Anna, additional, Brakke, Karin M., additional, Janssen, Axel, additional, Koopmans, Marijke A.H., additional, Lemmens, Toos, additional, Leurink, Titia, additional, Septer-Bijleveld, Engelien, additional, Stadhouders, Kimberly, additional, Troeman, Darren, additional, van der Waal, Marije, additional, van Opdorp, Marjoleine, additional, van Sluis, Nicolette, additional, Wolters, Beatrijs, additional, Kluytmans, Jan, additional, Romme, Jannie, additional, van den Bijllaardt, Wouter, additional, van Mook, Linda, additional, Rijen, M.M.L (Miranda) van, additional, Filius, P.M.G., additional, Gisolf, Jet, additional, Greven, Frances, additional, Huijbens, Danique, additional, Hassing, Robert Jan, additional, Pon, R.C., additional, Preijers, Lieke, additional, van Leusen, J.H., additional, Verheij, Harald, additional, Boersma, Wim, additional, Brans, Evelien, additional, Kloeg, Paul, additional, Molenaar-Groot, Kitty, additional, Nguyen, Nhat Khanh, additional, Paternotte, Nienke, additional, Rol, Anke, additional, Stooper, Lida, additional, Dijkstra, Helga, additional, Eggenhuizen, Esther, additional, Huijs, Lucas, additional, Moorlag, Simone, additional, Netea, Mihai, additional, Pranger, Eva, additional, Taks, Esther, additional, Oever, Jaap ten, additional, Heine, Rob ter, additional, Blauwendraat, Kitty, additional, Meek, Bob, additional, Erkaya, Isil, additional, Harbech, Houda, additional, Roescher, Nienke, additional, Peeters, Rifka, additional, Riele, Menno te, additional, Zhou, Carmen, additional, Calbo, Esther, additional, Marti, Cristina Badia, additional, Palomares, Emma Triviño, additional, Porcuna, Tomás Perez, additional, Barriocanal, Anabel, additional, Barriocanal, Ana Maria, additional, Casas, Irma, additional, Dominguez, Jose, additional, Esteve, Maria, additional, Lacoma, Alicia, additional, Latorre, Irene, additional, Molina, Gemma, additional, Molina, Barbara, additional, Rosell, Antoni, additional, Vidal, Sandra, additional, Barrera, Lydia, additional, Bustos, Natalia, additional, Calderón, Ines Portillo, additional, Campos, David Gutierrez, additional, Carretero, Jose Manuel, additional, Castellano, Angel Dominguez, additional, Compagnone, Renato, additional, Ramirez de Arellano, Encarnacion, additional, Serna, Almudena de la, additional, Dolores del Toro Lopez, Maria, additional, Clement Espindola, Marie-Alix, additional, Martin Gutierrez, Ana Belen, additional, Hernandez, Alvaro Pascual, additional, Jiménez, Virginia Palomo, additional, Moreno, Elisa, additional, Navarrete, Nicolas, additional, Paño, Teresa Rodriguez, additional, Rodríguez-Baño, Jesús, additional, Tristán, Enriqueta, additional, Rios Villegas, Maria Jose, additional, Garces, Atsegiñe Canga, additional, Amo, Erika Castro, additional, Guerrero, Raquel Coya, additional, Goikoetxea, Josune, additional, Jorge, Leticia, additional, Perez, Cristina, additional, Fariñas Álvarez, María Carmen, additional, Cuadra, Manuel Gutierrez, additional, Arnaiz de las Revillas Almajano, Francisco, additional, Garcia, Pilar Bohedo, additional, Poderos, Teresa Giménez, additional, Rico, Claudia González, additional, Sanchez, Blanca, additional, Valero, Olga, additional, Vega, Noelia, additional, Barnes, Anna, additional, Catterick, Helen, additional, Cranston, Tim, additional, Dawe, Phoebe, additional, Fletcher, Emily, additional, Fouracre, Liam, additional, Gifford, Alison, additional, Kirkwood, John, additional, Martin, Christopher, additional, McAnew, Amy, additional, Mitchell, Marcus, additional, Newman, Georgina, additional, O'Connell, Abby, additional, Onysk, Jakob, additional, Quinn, Lynne, additional, Rhodes, Shelley, additional, Stone, Samuel, additional, Symons, Lorrie, additional, Tripp, Harry, additional, Watkins, Darcy, additional, Whale, Bethany, additional, Harding, Alex, additional, Lockhart, Gemma, additional, Sidaway-Lee, Kate, additional, Hilton, Sam, additional, Manton, Sarah, additional, Webber-Rookes, Daniel, additional, Winder, Rachel, additional, Moore, James, additional, Bateman, Freya, additional, Gibbons, Michael, additional, Knight, Bridget, additional, Moss, Julie, additional, Statton, Sarah, additional, Studham, Josephine, additional, Hall, Lydia, additional, Moyle, Will, additional, and Venton, Tamsin, additional

Published
2023
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238. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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243. Estigmatización social en el tratamiento informativo de la obesidad en la prensa española durante la pandemia

Author

UDANE GOIKOETXEA-BILBAO, Idoia Camacho Markina, and Iñigo Marauri Castillo

Subjects
framing, Communication, análisis de contenido, COVID-19, periodismo digital, obesidad, estigmatización, prensa española
Abstract

Introducción: El presente estudio analiza el tratamiento de la obesidad en la prensa española durante el primer año de la pandemia de COVID-19, con el objetivo de conocer cómo se enmarcaron sus informaciones sobre este tema. Metodología: Mediante la metodología del análisis de contenido y con la teoría del framing como referencia, se estudiaron 350 informaciones acerca de obesidad y COVID-19 publicadas en las ediciones digitales de los cuatro diarios españoles impresos de información general más leídos en el año 2020: El País, El Mundo, La Vanguardia y Abc. Resultados: En los contenidos que protagoniza la obesidad prima el encuadre de responsabilidad individual, que atribuye la causa de la obesidad a la responsabilidad individual y que difunde la idea de que tener sobrepeso es una elección personal. Por el contrario, en aquellos centrados en la COVID-19 predomina el encuadre de responsabilidad colectiva. También se utiliza, aunque de manera minoritaria, lenguaje ofensivo e imágenes que reflejan de forma negativa a personas con obesidad. Discusión: Los medios de comunicación pueden influir en las creencias y actitudes de su audiencia, así como en la toma de decisiones sobre salud. Por ello, la forma en que los medios representan la obesidad es importante para aumentar o reducir la estigmatización hacia las personas que la sufren. Conclusiones: La narrativa que atribuye la causa de la obesidad a la responsabilidad individual fomenta el aumento del estigma social y refuerza los estereotipos basados en el peso, por lo que debería evitarse en los medios de comunicación.

Published
2023
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244. The Role of IoT Devices in Sustainable Car Expenses in the Context of the Intelligent Mobility: A Comparative Approach

Author

Javier Goikoetxea-Gonzalez, Diego Casado-Mansilla, and Diego López-de-Ipiña

Subjects
connected car, IoT, determinants, Delphi method, survey, car expenditures, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Connected cars have often been defined as vehicles that can provide some services and information without human intervention. Several scholars have examined the factors that promote the purchase or adoption of such augmented vehicles. However, little emphasis has been placed on the determinants for reducing car expenditures when a driver owns a car with an Internet of Things (IoT) device or a smart assistant in the context of smart mobility. Therefore, this article analyzes whether emerging technology such as IoT plays a key factor for a driver concerning the expenses related to the car (e.g., insurance, maintenance, and repairs). To this extent, a methodology based on exploratory (i) and confirmatory analysis (ii) was carried out. The authors initially conducted an exploratory phase by means of a Delphi method in which a group of vehicle experts (n = 25) were recruited to give their opinions and reach an agreement defining the determinants that they believed affected vehicle expenditures the most. Secondly, and taking into consideration that the salient determinant from the Delphi method was the use of technology and the warnings and alerts it triggers, a questionnaire was delivered to 556 drivers to analyze the everyday spending on their cars. Specifically, the survey aimed to compare the responses of people who own connected cars or have any kind of built-in IoT infrastructure (n = 302) with those of people with non-connected cars (n = 254). The main conclusion obtained for this latter approach was that drivers with a connected car have remarkably lower car expenses than those driving a conventional car.

Published
2022
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248. Transcreación y adaptación cultural en videojuegos: proceso, producto y recepción

Author

Itziar Zorrakin-Goikoetxea

Subjects
Linguistics and Language, Language and Linguistics
Abstract

Este estudio exploratorio trata de ampliar la información disponible sobre la transcreación en videojuegos conjugando datos del proceso, el producto y la recepción. Primero, se indaga en la familiarización de los desarrolladores de videojuegos con el concepto de transcreación mediante un muestreo probabilístico con encuesta. Después, se analizan dos juegos en los que se ha concedido más libertad creativa al traductor para comprobar si este hecho da lugar a más desviaciones del significado literal del texto de origen. Por último, una encuesta de recepción entre 569 jugadores tantea su opinión sobre la adaptación cultural en videojuegos. Los resultados muestran que la mayoría de los desarrolladores no están familiarizados con el concepto de transcreación, pero sí permiten que el traductor se distancie en cierta medida del texto de origen. Los jugadores tienen una opinión dividida sobre la importancia de la adaptación cultural y la traducción de nombres propios en videojuegos.

Published
2022
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249. Insuficiencia cardíaca de alto gasto por fístula arteriovenosa tras artrodesis lumbar

Author

Sabiñe Arakama Goikoetxea, Marc Soriano, Mireia Padilla, Juan Fernández, and David Viladez

Subjects
Pharmaceutical Science
Abstract

Presentamos el caso de una mujer de 53 años con antecedentes de cirugía lumbar que ingresa en varias ocasiones por insuficiencia cardíaca refractaria al tratamiento diurético. Las diferentes técnicas de imagen pudieron ayudar a determinar el tipo de insuficiencia cardíaca y la etiología de la misma. En este caso, se pudo llegar al diagnóstico de fístula arteriovenosa (FAV) como causa tratable de insuficiencia cardíaca de alto gasto.

Published
2022
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250. Survey on Localization From the Development Perspective.

Author

Zorrakin-Goikoetxea, Itziar

Subjects
DIGITAL video, VIDEO games, DIGITAL technology
Abstract

Localization is the adaptation of a video game at multiple levels to make it appealing for a new market and it greatly contributes to its success. Research regarding localization has been increasing for some years, but there are still close to no studies that analyze it from a development perspective. Through a survey of the developers of the video games available in Spanish on Steam (a popular video game digital distribution platform), we will show that the size and experience of the developing company influence the choice of the translator, the possibility to receive reference images, and the level of internationalization and revision applied. The sooner the localization is scheduled, the more likely the game is to be translated by a professional who can't play the game before translating it. The results hint at a multifaceted and relatively inexperienced industry that could learn from the experience of other companies. [ABSTRACT FROM AUTHOR]

Published
2024
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