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498 results on '"Girault, J.-A."'

201. [Influence of food intake on the bioavailability of ponsinomycin administered in a syrup form]

Author

Jb, Fourtillan, William Couet, Ingrand I, Reigner B, Bizouard J, and Girault J

Subjects
Adult, Male, Food, Biological Availability, Humans, Female, Miocamycin, Leucomycins, Chromatography, High Pressure Liquid
Abstract

Ponsinomycin is a new macrolide. Following oral administration, ponsinomycin is totally metabolized, even before reaching blood circulation. Metabolite Mb12 is the first compound on the main metabolic route, which can be assayed. The influence of food on ponsinomycin bioavailability has therefore been estimated from measurements of Mb12 plasma levels. Twelve young healthy volunteers received 800 mg of ponsinomycin as a syrup on two separate occasions, 2 hours before and during a standard meal. The Mb12 metabolite was assayed in plasma by High Pressure Liquid Chromatography (HPLC). Plasma peak concentrations and areas under curves were not significantly different but time to peak was significantly shorter when ponsinomycin was administered during meal. The results suggest that ponsinomycin absorption is faster when administered with food but quantitatively unchanged.

Published
1989

202. Statistical and Neuro-fuzzy approaches for emboli detection

Author

Kouamé, D., Biard, M., Girault, J. -M, Bleuzen, A., Tranquart, F., Frederic PATAT, Laboratoire Ultrasons Signaux et Instrumentation (LUSSI), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Traitement et Compréhension d’Images (IRIT-TCI), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), European Association for Signal Processing (EURASIP), and Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
cerebral emboli occurrence, human expert knowledge, autoregressive modelling, embolic TransCranial Doppler signal detection, neuro-fuzzy approaches, high performance microemboli detection technique, stroke, statistical approaches, performance evaluation, small size emboli detection, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, automatic signal parameter collection, AR modelling, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, TCD signal detection, cerebral vascular pathology monitoring
Abstract

International audience; Relation between cerebral emboli occurrence and stroke has been suggested these last years. Emboli detection has then become a constant concern while monitoring cerebral vascular pathologies. This detection is based on analysis of embolic TransCranial Doppler (TCD) signal. In practical experiments, most of detected emboli are big-size emboli ones, because of their easy-to-recognize signature in the TCD signal. The problem of small size emboli detection is an opened one and remains a challenge. Different approaches have been proposed to solve this problem. They use exclusively human expert knowledge or automatic collection of signal parameters. In this paper we propose to used both expert knowledge and automatic processing through neuro-fuzzy approach. Performances evaluation and comparison with high performance micro-emboli detection technique, namely Autoregressive (AR) modelling are provided, using in vitro in this work.

203. [Pharmacokinetics of ponsinomycin administered in a syrup form in single 400-800 and 1200 mg doses in healthy volunteers]

Author

William Couet, Girault J, Reigner B, Ingrand I, Bizouard J, and Jb, Fourtillan

Subjects
Adult, Male, Administration, Oral, Humans, Female, Miocamycin, Leucomycins, Drug Administration Schedule
Abstract

Ponsinomycin is a new macrolide. Its pharmacokinetics is characterized by an extensive metabolism. Following oral dosing in human, unchanged ponsinomycin is not found in blood, but 3 main metabolites: Mb12, Mb6 and Mb9a can be assayed. Twelve young healthy volunteers received ponsinomycin orally, at doses equal to 400, 800 and 1,200 mg on 3 separate occasions, according to a cross-over design. Metabolites Mb12, Mb6 and Mb9a were measured in plasma by HPLC. The pharmacokinetics of Mb12 was linear in the range of doses administered. A dose-dependent effect leading to a reduction of the apparent elimination rate when dose increased was observed with Mb9a and more importantly with Mb6.

205. Steady-state bioavailability and pharmacokinetics of ambroxol and clenbuterol administered alone and combined in a new oral formulation

Author

William Couet, Girault J, Bg, Reigner, Ingrand I, Bizouard J, Acerbi D, Chiesi P, and Jb, Fourtillan

Subjects
Adult, Male, Quality Control, Ambroxol, Bromhexine, Drug Combinations, Ethanolamines, Administration, Oral, Biological Availability, Humans, Clenbuterol, Half-Life
Abstract

Ambroxol and clenbuterol are two drugs with potential pharmacological synergy. The objective of this study was to compare the apparent bioavailabilities at steady-state of these two compounds administered alone or in combination (CHF-023). Nine healthy male volunteers participated in the study. They received 30 mg of ambroxol alone (one Fluibron tablet), or 20 micrograms of clenbuterol alone (one Spiropent tablet), or 30 mg of ambroxol plus 20 micrograms of clenbuterol in combination (one CHF-023 tablet), every 12 hours for 7 days on three separate occasions. Ambroxol and clenbuterol concentrations were measured in plasma by appropriate GC/MS methods. Pharmacokinetic parameters were calculated by non-compartmental methods and submitted to statistical comparisons. Compartmental analysis was also performed on data provided by CHF-023 treatment. It was concluded that apparent bioavailabilities of ambroxol and clenbuterol are almost identical in Fluibron and CHF-023 tablets, and in Spiropent and CHF-023 tablets, respectively, with no statistically significant differences between pharmacokinetic parameters calculated for these two drugs during different treatments, except for peak concentration of ambroxol.

250. Isolation and Structural Elucidation of Two Plant Ecdysteroids, Gerardiasterone and 22-Epi-20-hydroxyecdysone

Author

Bathori, M., Mathe, I., Girault, J.-P., Kalasz, H., and Lafont, R.

Abstract

Two minor plant ecdysteroids, 22-epi-20-hydroxyecdysone (1) and gerardiasterone (2), were isolated from Serratula tinctoria L. (Compositae). The first compound, a new natural product, was characterized by an unusual stereochemistry at C-22 (i.e., 22S). The second compound was identified as (20R,23S)-20,23-dihydroxyecdysone, a compound previously isolated from the Zooanthid Gerardia savaglia.

Published
1998

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