18,247 results on '"Giles, P. A."'
Search Results
202. A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
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Morgan, Pooranee K., Pernes, Gerard, Huynh, Kevin, Giles, Corey, Paul, Sudip, Smith, Adam Alexander T., Mellett, Natalie A., Liang, Amy, van Buuren-Milne, Tilly, Veiga, Camilla Bertuzzo, Collins, Thomas J. C., Xu, Yangsong, Lee, Man K. S., De Silva, T. Michael, Meikle, Peter J., Lancaster, Graeme I., and Murphy, Andrew J.
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- 2024
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203. Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
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Zhao, Yajie, Chukanova, Maria, Kentistou, Katherine A., Fairhurst-Hunter, Zammy, Siegert, Anna Maria, Jia, Raina Y., Dowsett, Georgina K. C., Gardner, Eugene J., Lawler, Katherine, Day, Felix R., Kaisinger, Lena R., Tung, Yi-Chun Loraine, Lam, Brian Yee Hong, Chen, Hsiao-Jou Cortina, Wang, Quanli, Berumen-Campos, Jaime, Kuri-Morales, Pablo, Tapia-Conyer, Roberto, Alegre-Diaz, Jesus, Barroso, Inês, Emberson, Jonathan, Torres, Jason M., Collins, Rory, Saleheen, Danish, Smith, Katherine R., Paul, Dirk S., Merkle, Florian, Farooqi, I. Sadaf, Wareham, Nick J., Petrovski, Slavé, O’Rahilly, Stephen, Ong, Ken K., Yeo, Giles S. H., and Perry, John R. B.
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- 2024
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204. 15-Year Analysis of Surgical Approaches and Outcomes for Coarctation in 132 Neonates and Infants
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Stukov, Yuriy, Jacobs, Jeffrey P., Sharaf, Omar M., Peek, Giles J., Pitkin, Andrew D., Cruz Beltrán, Susana C., Lopez-Colon, Dalia, Nixon, Connie S., and Bleiweis, Mark S.
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- 2024
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205. Waiting times between examinations with intravascularly administered contrast media: a review of contrast media pharmacokinetics and updated ESUR Contrast Media Safety Committee guidelines
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van der Molen, Aart J., Dekkers, Ilona A., Geenen, Remy W. F., Bellin, Marie-France, Bertolotto, Michele, Brismar, Torkel B., Correas, Jean-Michel, Heinz-Peer, Gertraud, Mahnken, Andreas H., Quattrocchi, Carlo C., Radbruch, Alexander, Reimer, Peter, Roditi, Giles, Romanini, Laura, Sebastià, Carmen, Stacul, Fulvio, and Clement, Olivier
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- 2024
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206. Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
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Yu, Daqi, Ren, Yandong, Uesaka, Masahiro, Beavan, Alan J. S., Muffato, Matthieu, Shen, Jieyu, Li, Yongxin, Sato, Iori, Wan, Wenting, Clark, James W., Keating, Joseph N., Carlisle, Emily M., Dearden, Richard P., Giles, Sam, Randle, Emma, Sansom, Robert S., Feuda, Roberto, Fleming, James F., Sugahara, Fumiaki, Cummins, Carla, Patricio, Mateus, Akanni, Wasiu, D’Aniello, Salvatore, Bertolucci, Cristiano, Irie, Naoki, Alev, Cantas, Sheng, Guojun, de Mendoza, Alex, Maeso, Ignacio, Irimia, Manuel, Fromm, Bastian, Peterson, Kevin J., Das, Sabyasachi, Hirano, Masayuki, Rast, Jonathan P., Cooper, Max D., Paps, Jordi, Pisani, Davide, Kuratani, Shigeru, Martin, Fergal J., Wang, Wen, Donoghue, Philip C. J., Zhang, Yong E., and Pascual-Anaya, Juan
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- 2024
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207. Association between adherence to the EAT-Lancet sustainable reference diet and cardiovascular health among European adolescents: the HELENA study
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Cacau, Leandro Teixeira, Hanley-Cook, Giles T., Vandevijvere, Stefanie, Leclercq, Catherine, De Henauw, Stefaan, Santaliestra-Pasias, Alba, Manios, Yannis, Mourouti, Niki, Esperanza Díaz, Ligia, Gonzalez-Gross, Marcela, Widhalm, Kurt, Molnar, Dénes, Stehle, Peter, Kafatos, Anthony, Gottrand, Frederic, Kersting, Mathilde, Castillo, Manuel, Lachat, Carl, Marchioni, Dirce Maria, Huybrechts, Inge, and Moreno, Luis A.
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- 2024
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208. Cost Effectiveness of Additional Preoperative Telephone Call to Increase Surgical Preparedness: Analysis of a Randomized Clinical Trial
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Halder, Gabriela E., Guo, Fangjian, Harvie, Heidi, White, Amanda B., Caldwell, Lauren, Giles, Dobie L., Bilagi, Daksha, and Rogers, Rebecca G.
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- 2024
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209. Three-dimensional energy transfer in space plasma turbulence from multipoint measurement
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Pecora, Francesco, Servidio, Sergio, Yang, Yan, Matthaeus, William H., Chasapis, Alexandros, Greco, Antonella, Gershman, Daniel J., Giles, Barbara L., and Burch, James L.
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Physics - Space Physics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics - Abstract
A novel multispacecraft technique applied to Magnetospheric Multiscale (MMS) mission data collected in the Earth's magnetosheath enables evaluation of the energy cascade rate solving the full Yaglom's equation in a turbulent space plasma. The method differs from existing approaches in that (i) it is inherently three-dimensional; (ii) it provides a statistically significant number of estimates from a single data stream; and (iii) it allows for a direct visualization of energy flux in turbulent plasmas. This new technique will ultimately provide a realistic, comprehensive picture of the turbulence process in plasmas.
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- 2023
210. Dual-ratio approach for detection of point fluorophores in biological tissue
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Blaney, Giles, Ivich, Fernando, Sassaroli, Angelo, Niedre, Mark, and Fantini, Sergio
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Physics - Medical Physics ,Physics - Optics ,Quantitative Biology - Quantitative Methods - Abstract
Significance: Diffuse in-vivo Flow Cytometry (DiFC) is an emerging fluorescence sensing method to non-invasively detect labeled circulating cells in-vivo. However, due to Signal-to-Noise Ratio (SNR) constraints largely attributed to background tissue autofluorescence, DiFC's measurement depth is limited. multiplies Aim: The Dual-Ratio (DR) / dual-slope is a new optical measurement method that aims to suppress noise and enhance SNR to deep tissue regions. We aim to investigate the combination of DR and Near-InfraRed (NIR) DiFC to improve circulating cells' maximum detectable depth and SNR. Approach: Phantom experiments were used to estimate the key parameters in a diffuse fluorescence excitation and emission model. This model and parameters were implemented in Monte-Carlo to simulate DR DiFC while varying noise and autofluorescence parameters to identify the advantages and limitations of the proposed technique. Results: Two key factors must be true to give DR DiFC an advantage over traditional DiFC; first, the fraction of noise that DR methods cannot cancel cannot be above the order of 10% for acceptable SNR. Second, DR DiFC has an advantage, in terms of SNR, if the distribution of tissue autofluorescence contributors is surface-weighted. Conclusions: DR cancelable noise may be designed for (e.g. through the use of source multiplexing), and indications point to the autofluorescence contributors' distribution being truly surface-weighted in-vivo. Successful and worthwhile implementation of DR DiFC depends on these considerations, but results point to DR DiFC having possible advantages over traditional DiFC.
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- 2023
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211. A Race Track Trapped-Ion Quantum Processor
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Moses, S. A., Baldwin, C. H., Allman, M. S., Ancona, R., Ascarrunz, L., Barnes, C., Bartolotta, J., Bjork, B., Blanchard, P., Bohn, M., Bohnet, J. G., Brown, N. C., Burdick, N. Q., Burton, W. C., Campbell, S. L., Campora III, J. P., Carron, C., Chambers, J., Chan, J. W., Chen, Y. H., Chernoguzov, A., Chertkov, E., Colina, J., Curtis, J. P., Daniel, R., DeCross, M., Deen, D., Delaney, C., Dreiling, J. M., Ertsgaard, C. T., Esposito, J., Estey, B., Fabrikant, M., Figgatt, C., Foltz, C., Foss-Feig, M., Francois, D., Gaebler, J. P., Gatterman, T. M., Gilbreth, C. N., Giles, J., Glynn, E., Hall, A., Hankin, A. M., Hansen, A., Hayes, D., Higashi, B., Hoffman, I. M., Horning, B., Hout, J. J., Jacobs, R., Johansen, J., Jones, L., Karcz, J., Klein, T., Lauria, P., Lee, P., Liefer, D., Lytle, C., Lu, S. T., Lucchetti, D., Malm, A., Matheny, M., Mathewson, B., Mayer, K., Miller, D. B., Mills, M., Neyenhuis, B., Nugent, L., Olson, S., Parks, J., Price, G. N., Price, Z., Pugh, M., Ransford, A., Reed, A. P., Roman, C., Rowe, M., Ryan-Anderson, C., Sanders, S., Sedlacek, J., Shevchuk, P., Siegfried, P., Skripka, T., Spaun, B., Sprenkle, R. T., Stutz, R. P., Swallows, M., Tobey, R. I., Tran, A., Tran, T., Vogt, E., Volin, C., Walker, J., Zolot, A. M., and Pino, J. M.
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Quantum Physics - Abstract
We describe and benchmark a new quantum charge-coupled device (QCCD) trapped-ion quantum computer based on a linear trap with periodic boundary conditions, which resembles a race track. The new system successfully incorporates several technologies crucial to future scalability, including electrode broadcasting, multi-layer RF routing, and magneto-optical trap (MOT) loading, while maintaining, and in some cases exceeding, the gate fidelities of previous QCCD systems. The system is initially operated with 32 qubits, but future upgrades will allow for more. We benchmark the performance of primitive operations, including an average state preparation and measurement error of 1.6(1)$\times 10^{-3}$, an average single-qubit gate infidelity of $2.5(3)\times 10^{-5}$, and an average two-qubit gate infidelity of $1.84(5)\times 10^{-3}$. The system-level performance of the quantum processor is assessed with mirror benchmarking, linear cross-entropy benchmarking, a quantum volume measurement of $\mathrm{QV}=2^{16}$, and the creation of 32-qubit entanglement in a GHZ state. We also tested application benchmarks including Hamiltonian simulation, QAOA, error correction on a repetition code, and dynamics simulations using qubit reuse. We also discuss future upgrades to the new system aimed at adding more qubits and capabilities., Comment: 24 pages, 24 figures. Made some minor edits and added several more authors
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- 2023
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212. Cool Cores in Clusters of Galaxies in the Dark Energy Survey
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Graham, K., O'Donnell, J., Silverstein, M. M., Eiger, O., Jeltema, T. E., Hollowood, D. L., Cross, D., Everett, S., Giles, P., Jobel, J., Laubner, D., McDaniel, A., Romer, A. K., Swart, A., Aguena, M., Allam, S., Alves, O., Brooks, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., Pereira, M. E. S., De Vicente, J., Desai, S., Dietrich, J. P., Doel, P., Ferrero, I., Frieman, J., Garcia-Bellido, J., Gruen, D., Gruendl, R. A., Hinton, S. R., Honscheid, K., James, D. J., Kuehn, K., Kuropatkin, N., Lahav, O., Marshall, J. L., Melchior, P., Mena-Fernandez, J., Menanteau, F., Miquel, R., Ogando, R. L. C., Palmese, A., Pieres, A., Malagon, A. A. Plazas, Reil, K., Rodriguez-Monroy, M., Sanchez, E., Scarpine, V., Schubnell, M., Smith, M., Suchyta, E., Tarle, G., To, C., and Weaverdyck, N.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We search for the presence of cool cores in optically-selected galaxy clusters from the Dark Energy Survey (DES) and investigate their prevalence as a function of redshift and cluster richness. Clusters were selected from the redMaPPer analysis of three years of DES observations that have archival Chandra X-ray observations, giving a sample of 99 clusters with a redshift range of $0.11 < z < 0.87$ and a richness range of $25 < \lambda < 207$. Using the X-ray data, the core temperature was compared to the outer temperature to identify clusters where the core temperature is a factor of 0.7 or less than the outer temperature. We found a cool core fraction of approximately 20% with no significant trend in the cool core fraction with either redshift or richness., Comment: shortened version accepted to RNAAS
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- 2023
213. The Io, Europa and Ganymede auroral footprints at Jupiter in the ultraviolet: positions and equatorial lead angles
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Hue, Vincent, Gladstone, Randy, Louis, Corentin K., Greathouse, Thomas K., Bonfond, Bertrand, Szalay, Jamey R., Moirano, Alessandro, Giles, Rohini S., Kammer, Joshua A., Imai, Masafumi, Mura, Alessandro, Versteeg, Maarten H., Clark, George, Gérard, Jean-Claude, Grodent, Denis C., Rabia, Jonas, Sulaiman, Ali H., Bolton, Scott J., and Connerney, John E. P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Jupiter's satellite auroral footprints are a consequence of the interaction between the Jovian magnetic field with co-rotating iogenic plasma and the Galilean moons. The disturbances created near the moons propagate as Alfv\'en waves along the magnetic field lines. The position of the moons is therefore "Alfv\'enically" connected to their respective auroral footprint. The angular separation from the instantaneous magnetic footprint can be estimated by the so-called lead angle. That lead angle varies periodically as a function of orbital longitude, since the time for the Alfv\'en waves to reach the Jovian ionosphere varies accordingly. Using spectral images of the Main Alfv\'en Wing auroral spots collected by Juno-UVS during the first forty-three orbits, this work provides the first empirical model of the Io, Europa and Ganymede equatorial lead angles for the northern and southern hemispheres. Alfv\'en travel times between the three innermost Galilean moons to Jupiter's northern and southern hemispheres are estimated from the lead angle measurements. We also demonstrate the accuracy of the mapping from the Juno magnetic field reference model (JRM33) at the completion of the prime mission for M-shells extending to at least 15RJ . Finally, we shows how the added knowledge of the lead angle can improve the interpretation of the moon-induced decametric emissions., Comment: 20 pages, 8 figures, Accepted for publication in Journal of Geophysical Research: Space Physics on 20 April 2023
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- 2023
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214. The XMM Cluster Survey: Exploring scaling relations and completeness of the Dark Energy Survey Year 3 redMaPPer cluster catalogue
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Upsdell, E. W., Giles, P. A., Romer, A. K., Wilkinson, R., Turner, D. J., Hilton, M., Rykoff, E., Farahi, A., Bhargava, S., Jeltema, T., Klein, M., Bermeo, A., Collins, C. A., Ebrahimpour, L., Hollowood, D., Mann, R. G., Manolopoulou, M., Miller, C. J., Rooney, P. J., Sahlén, Martin, Stott, J. P., Viana, P. T. P., Allam, S., Alves, O., Bacon, D., Bertin, E., Bocquet, S., Brooks, D., Burke, D. L., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., Pereira, M. E. S., De Vicente, J., Desai, S., Diehl, H. T., Dietrich, J. P., Everett, S., Ferrero, I., Frieman, J., García-Bellido, J., Gerdes, D. W., Gutierrez, G., Hinton, S. R., Honscheid, K., James, D. J., Kuehn, K., Kuropatkin, N., Lima, M., Marshall, J. L., Mena-Fern, J., Menanteau, F., Miquel, R., Mohr, J. J., Ogando, R. L. C., Pieres, A., Raveri, M., Rodriguez-Monroy, M., Sanchez, E., Scarpine, V., Sevilla-Noarbe, I., Smith, M., Suchyta, E., Swanson, M. E. C., Tarle, G., To, C., Weaverdyck, N., Weller, J., and Wiseman, P.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We cross-match and compare characteristics of galaxy clusters identified in observations from two sky surveys using two completely different techniques. One sample is optically selected from the analysis of three years of Dark Energy Survey observations using the redMaPPer cluster detection algorithm. The second is X-ray selected from XMM observations analysed by the XMM Cluster Survey. The samples comprise a total area of 57.4 deg$^2$, bounded by the area of 4 contiguous XMM survey regions that overlap the DES footprint. We find that the X-ray selected sample is fully matched with entries in the redMaPPer catalogue, above $\lambda>$20 and within 0.1$< z <$0.9. Conversely, only 38\% of the redMaPPer catalogue is matched to an X-ray extended source. Next, using 120 optically clusters and 184 X-ray selected clusters, we investigate the form of the X-ray luminosity-temperature ($L_{X}-T_{X}$), luminosity-richness ($L_{X}-\lambda$) and temperature-richness ($T_{X}-\lambda$) scaling relations. We find that the fitted forms of the $L_{X}-T_{X}$ relations are consistent between the two selection methods and also with other studies in the literature. However, we find tentative evidence for a steepening of the slope of the relation for low richness systems in the X-ray selected sample. When considering the scaling of richness with X-ray properties, we again find consistency in the relations (i.e., $L_{X}-\lambda$ and $T_{X}-\lambda$) between the optical and X-ray selected samples. This is contrary to previous similar works that find a significant increase in the scatter of the luminosity scaling relation for X-ray selected samples compared to optically selected samples., Comment: Accepted for publication to MNRAS
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- 2023
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215. Yield Strength-Plasticity Trade-Off and Uncertainty Quantification for Machine-learning-based Design of Refractory High-Entropy Alloys
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Giles, Stephen A., Shortt, Hugh, Liaw, Peter K., and Sengupta, Debasis
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Condensed Matter - Materials Science - Abstract
Development of process-structure-property relationships in materials science is an important and challenging frontier which promises improved materials and reduced time and cost in production. Refractory high entropy alloys (RHEAs) are a class of materials that are capable of excellent hightemperature properties. However, due to their multi-component nature, RHEAs have a vast composition space which presents challenges for traditional experimental exploration. Here, quantitative models of compressive yield strength and room-temperature plasticity are developed through a deep learning approach. Uncertainty quantification is performed through a variety of statistical validation techniques. Model predictions are experimentally validated through collection of recent literature and the synthesis and experimental characterization of two new, unreported RHEAs: AlMoTaTiZr and Al0.239Mo0.123Ta0.095Ti0.342Zr0.201. Finally, through the application of model interpretability, features having the greatest impact on both the mechanical property and uncertainty of the deep learning models are revealed, and shown to agree well with current physics and materials science theory.
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- 2023
216. Jupiter Science Enabled by ESA's Jupiter Icy Moons Explorer
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Fletcher, Leigh N., Cavalié, Thibault, Grassi, Davide, Hueso, Ricardo, Lara, Luisa M., Kaspi, Yohai, Galanti, Eli, Greathouse, Thomas K., Molyneux, Philippa M., Galand, Marina, Vallat, Claire, Witasse, Olivier, Lorente, Rosario, Hartogh, Paul, Poulet, François, Langevin, Yves, Palumbo, Pasquale, Gladstone, G. Randall, Retherford, Kurt D., Dougherty, Michele K., Wahlund, Jan-Erik, Barabash, Stas, Iess, Luciano, Bruzzone, Lorenzo, Hussmann, Hauke, Gurvits, Leonid I., Santolik, Ondřej, Kolmasova, Ivana, Fischer, Georg, Müller-Wodarg, Ingo, Piccioni, Giuseppe, Fouchet, Thierry, Gérard, Jean-Claude, Sánchez-Lavega, Agustin, Irwin, Patrick G. J., Grodent, Denis, Altieri, Francesca, Mura, Alessandro, Drossart, Pierre, Kammer, Josh, Giles, Rohini, Cazaux, Stéphanie, Jones, Geraint, Smirnova, Maria, Lellouch, Emmanuel, Medvedev, Alexander S., Moreno, Raphael, Rezac, Ladislav, Coustenis, Athena, and Costa, Marc
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
ESA's Jupiter Icy Moons Explorer (JUICE) will provide a detailed investigation of the Jovian system in the 2030s, combining a suite of state-of-the-art instruments with an orbital tour tailored to maximise observing opportunities. We review the Jupiter science enabled by the JUICE mission, building on the legacy of discoveries from the Galileo, Cassini, and Juno missions, alongside ground- and space-based observatories. We focus on remote sensing of the climate, meteorology, and chemistry of the atmosphere and auroras from the cloud-forming weather layer, through the upper troposphere, into the stratosphere and ionosphere. The Jupiter orbital tour provides a wealth of opportunities for atmospheric and auroral science: global perspectives with its near-equatorial and inclined phases, sampling all phase angles from dayside to nightside, and investigating phenomena evolving on timescales from minutes to months. The remote sensing payload spans far-UV spectroscopy (50-210 nm), visible imaging (340-1080 nm), visible/near-infrared spectroscopy (0.49-5.56 $\mu$m), and sub-millimetre sounding (near 530-625\,GHz and 1067-1275\,GHz). This is coupled to radio, stellar, and solar occultation opportunities to explore the atmosphere at high vertical resolution; and radio and plasma wave measurements of electric discharges in the Jovian atmosphere and auroras. Cross-disciplinary scientific investigations enable JUICE to explore coupling processes in giant planet atmospheres, to show how the atmosphere is connected to (i) the deep circulation and composition of the hydrogen-dominated interior; and (ii) to the currents and charged particle environments of the external magnetosphere. JUICE will provide a comprehensive characterisation of the atmosphere and auroras of this archetypal giant planet., Comment: 83 pages, 24 figures, accepted to Space Science Reviews special issue on ESA's JUICE mission
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- 2023
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217. A high spatial and spectral resolution study of Jupiter's mid-infrared auroral emissions and their response to a solar wind compression
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Sinclair, James A, Greathouse, Thomas K, Giles, Rohini S, Lacy, John, Moses, Julianne, Hue, Vincent, Grodent, Denis, Bonfond, Bertrand, Tao, Chihiro, Cavalié, Thibault, Dahl, Emma K, Orton, Glenn S, Fletcher, Leigh N, and Irwin, Patrick G J
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present mid-infrared spectroscopy of Jupiter's mid-to-high latitudes using Gemini-North/TEXES (Texas Echelon Cross Echelle Spectrograph) on March 17-19, 2017. These observations capture Jupiter's hydrocarbon auroral emissions before, during and after the arrival of a solar wind compression on March 18th, which highlights the coupling between the polar stratosphere and external space environment. In comparing observations on March 17th and 19th, we observe a brightening of the CH$_4$, C$_2$H$_2$ and C$_2$H$_4$ emissions in regions spatially coincident with the northern, duskside main auroral emission (henceforth, MAE). In inverting the spectra to derive atmospheric information, we determine that the duskside brightening results from an upper stratospheric (p < 0.1 mbar/z > 200 km) heating (e.g. $\Delta T$ = 9.1 $\pm$ 2.1 K at 9 $\mu$bar at 67.5$^\circ$N, 162.5$^\circ$W) with negligible heating at deeper pressures. Our interpretation is that the arrival of the solar wind enhancement drove magnetospheric dynamics through compression and/or viscous interactions on the flank. These dynamics accelerated currents and/or generated higher Poynting fluxes, which ultimately warmed the atmosphere through Joule heating and ion-neutral collisions. Poleward of the southern MAE, temperature retrievals demonstrate that auroral-related heating penetrates as deep as the 10-mbar level, in contrast to poleward of the northern MAE, where heating is only observed as deep as $\sim$3 mbar. We suggest this results from the south having higher Pedersen conductivities, and therefore stronger currents and acceleration of the neutrals, as well as the poleward heating overlapping with the apex of Jupiter's circulation thereby inhibiting efficient horizontal mixing/advection.
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- 2023
218. Fermi-GBM Discovery of GRB 221009A: An Extraordinarily Bright GRB from Onset to Afterglow
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Lesage, S., Veres, P., Briggs, M. S., Goldstein, A., Kocevski, D., Burns, E., Wilson-Hodge, C. A., Bhat, P. N., Huppenkothen, D., Fryer, C. L., Hamburg, R., Racusin, J., Bissaldi, E., Cleveland, W. H., Dalessi, S., Fletcher, C., Giles, M. M., Hristov, B. A., Hui, C. M., Mailyan, B., Malacaria, C., Poolakkil, S., Roberts, O. J., von Kienlin, A., Wood, J., Ajello, M., Arimoto, M., Baldini, L., Ballet, J., Baring, M. G., Bastieri, D., Gonzalez, J. Becerra, Bellazzini, R., Blandford, R. D., Bonino, R., Bruel, P., Buson, S., Cameron, R. A., Caputo, R., Caraveo, P. A., Cavazzuti, E., Chiaro, G., Cibrario, N., Ciprini, S., Orestano, P. Cristarella, Crnogorcevic, M., Cuoco, A., Cutini, S., DAmmando, F., De Gaetano, S., Di Lalla, N., Di Venere, L., Dominguez, A., Fegan, S. J., Ferrara, E. C., Fleischhack, H., Fukazawa, Y., Funk, S., Fusco, P., Galanti, G., Gammaldi, V., Gargano, F., Gasbarra, C., Gasparrini, D., Germani, S., Giacchino, F., Giglietto, N., Gill, R., Giroletti, M., Granot, J., Green, D., Grenier, I. A., Guiriec, S., Gustafsson, M., Hays, E., Hewitt, J. W., Horan, D., Hou, X., Kuss, M., Latronico, L., Laviron, A., Lemoine-Goumard, M., Li, J., Liodakis, I., Longo, F., Loparco, F., Lorusso, L., Lovellette, M. N., Lubrano, P., Maldera, S., Manfreda, A., Marti-Devesa, G., Mazziotta, M. N., McEnery, J. E., Mereu, I., Meyer, M., Michelson, P. F., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Negro, M., Nuss, E., Omodei, N., Orlando, E., Ormes, J. F., Paneque, D., Panzarini, G., Persic, M., Pesce-Rollins, M., Pillera, R., Piron, F., Poon, H., Porter, T. A., Principe, G., Raino, S., Rando, R., Rani, B., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Ryde, F., Sanchez-Conde, M., Parkinson, P. M. Saz, Scotton, L., Serini, D., Sgro, C., Sharma, V., Siskind, E. J., Spandre, G., Spinelli, P., Tajima, H., Torres, D. F., Valverde, J., Venters, T., Wadiasingh, Z., Wood, K., and Zaharijas, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report the discovery of GRB 221009A, the highest flux gamma-ray burst ever observed by the Fermi Gamma-ray Burst Monitor (GBM). This GRB has continuous prompt emission lasting more than 600 seconds which smoothly transitions to afterglow visible in the GBM energy range (8 keV--40 MeV), and total energetics higher than any other burst in the GBM sample. By using a variety of new and existing analysis techniques we probe the spectral and temporal evolution of GRB 221009A. We find no emission prior to the GBM trigger time (t0; 2022 October 9 at 13:16:59.99 UTC), indicating that this is the time of prompt emission onset. The triggering pulse exhibits distinct spectral and temporal properties suggestive of the thermal, photospheric emission of shock-breakout, with significant emission up to $\sim$15 MeV. We characterize the onset of external shock at t0+600 s and find evidence of a plateau region in the early-afterglow phase which transitions to a slope consistent with Swift-XRT afterglow measurements. We place the total energetics of GRB 221009A in context with the rest of the GBM sample and find that this GRB has the highest total isotropic-equivalent energy ($\textrm{E}_{\gamma,\textrm{iso}}=1.0\times10^{55}$ erg) and second highest isotropic-equivalent luminosity ($\textrm{L}_{\gamma,\textrm{iso}}=9.9\times10^{53}$ erg/s) based on redshift of z = 0.151. These extreme energetics are what allowed us to observe the continuously emitting central engine of GBM from the beginning of the prompt emission phase through the onset of early afterglow., Comment: 26 pages 7 figures - accepted for publication in ApJL
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- 2023
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219. Disentangling centrality bias and final-state effects in the production of high-$p_T$ $\pi^0$ using direct $\gamma$ in $d$$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV
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Abdulameer, N. J., Acharya, U., Aidala, C., Akiba, Y., Alfred, M., Aoki, K., Apadula, N., Ayuso, C., Babintsev, V., Barish, K. N., Bathe, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Boer, M., Bok, J. S., Borisov, V., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Butler, C., Campbell, S., Roman, V. Canoa, Chiu, M., Connors, M., Corliss, R., Morales, Y. Corrales, Csanád, M., Csörgő, T., Liu, L. D., Danley, T. W., Daugherity, M. S., David, G., Dean, C. T., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Doomra, V., Do, J. H., Drees, A., Drees, K. A., Dumancic, M., Durham, J. M., Durum, A., Elder, T., Enokizono, A., Esha, R., Fadem, B., Fan, W., Feege, N., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gal, C., Garg, P., Ge, H., Giles, M., Goto, Y., Grau, N., Greene, S. V., Gunji, T., Hachiya, T., Haggerty, J. S., Hahn, K. I., Han, S. Y., Harvey, M., Hasegawa, S., Haseler, T. O. S., Hemmick, T. K., He, X., Hill, K., Hodges, A., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Imrek, J., Inaba, M., Isenhower, D., Ito, Y., Ivanishchev, D., Jacak, B. V., Ji, Z., Johnson, B. M., Jorjadze, V., Jouan, D., Jumper, D. S., Kang, J. H., Kapukchyan, D., Karthas, S., Kazantsev, A. V., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kim, C., Kim, D. J., Kim, E. -J., Kim, M., Kim, M. H., Kim, T., Kincses, D., Kingan, A., Kistenev, E., Koblesky, T., Kotov, D., Kovacs, L., Kudo, S., Kurgyis, B., Kurita, K., Lajoie, J. G., Lallow, E. O., Larionova, D., Lebedev, A., Lee, S. H., Leitch, M. J., Leung, Y. H., Lewis, N. A., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Loomis, D. A., Lynch, D., Lökös, S., Majoros, T., Makek, M., Malaev, M., Manko, V. I., Mannel, E., Masuda, H., McCumber, M., McGlinchey, D., Mignerey, A. C., Mihalik, D. E., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Mondal, M. M., Moon, T., Morrison, D. P., Morrow, S. I., Muhammad, A., Mulilo, B., Murakami, T., Murata, J., Nagai, K., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Nouicer, R., Novitzky, N., Novotny, R., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ozawa, K., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Patel, M., Pate, S. F., Peng, W., Perepelitsa, D. V., Perera, G. D. N., PerezLara, C. E., Petti, R., Phipps, M., Pinkenburg, C., Potekhin, M., Pun, A., Purschke, M. L., Radzevich, P. V., Ramasubramanian, N., Read, K. F., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rosati, M., Rowan, Z., Runchey, J., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, K., Sato, S., Schaefer, B., Schmoll, B. K., Seidl, R., Sen, A., Seto, R., Sexton, A., Sharma, D., Shein, I., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shi, Z., Silva, C. L., Silvermyr, D., Slunečka, M., Smith, K. L., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, Z., Syed, S., Takahama, R., Takeda, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Towell, C. L., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vazquez-Carson, S., Velkovska, J., Virius, M., Vrba, V., Wang, X. R., Wang, Z., Watanabe, Y., Wong, C. P., Xu, C., Xu, Q., Yamaguchi, Y. L., Yanovich, A., Yin, P., Yoon, I., Yoo, J. H., Yushmanov, I. E., Yu, H., Zajc, W. A., and Zou, L.
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Nuclear Experiment - Abstract
PHENIX presents a simultaneous measurement of the production of direct $\gamma$ and $\pi^0$ in $d$$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV over a $p_T$ range of 7.5 to 18 GeV/$c$ for different event samples selected by event activity, i.e. charged-particle multiplicity detected at forward rapidity. Direct-photon yields are used to empirically estimate the contribution of hard-scattering processes in the different event samples. Using this estimate, the average nuclear-modification factor $R_{d\rm Au,EXP}^{\gamma^{\rm dir}}$ is $0.925{\pm}0.023({\rm stat}){\pm}0.15^{\rm (scale)}$, consistent with unity for minimum-bias (MB) $d$$+$Au events. For event classes with moderate event activity, $R_{d\rm Au,EXP}^{\gamma^{\rm dir}}$ is consistent with the MB value within 5\% uncertainty. These results confirm that the previously observed enhancement of high-$p_T$ $\pi^0$ production found in small-system collisions with low event activity is a result of a bias in interpreting event activity within the Glauber framework. In contrast, for the top 5\% of events with the highest event activity, $R_{d\rm Au,EXP}^{\gamma^{\rm dir}}$ is suppressed by 20\% relative to the MB value with a significance of $4.5\sigma$, which may be due to final-state effects., Comment: 279 authors from 69 institutions, 8 pages, 3 figures, v1 is version submitted to Physical Review Letters. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
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- 2023
220. Transverse single-spin asymmetry of charged hadrons at forward and backward rapidity in polarized $p$+$p$, $p$+Al, and $p$+Au collisions at $\sqrt{s_{NN}}=200$ GeV}
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Abdulameer, N. J., Acharya, U., Aidala, C., Akiba, Y., Alfred, M., Andrieux, V., Apadula, N., Asano, H., Azmoun, B., Babintsev, V., Bandara, N. S., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Cervantes, R., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Citron, Z., Connors, M., Corliss, R., Morales, Y. Corrales, Cronin, N., Csanád, M., Csörgő, T., Danley, T. W., Daugherity, M. S., David, G., Dean, C. T., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dion, A., Dixit, D., Doomra, V., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., En'yo, H., Enokizono, A., Esha, R., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gallus, P., Gal, C., Garg, P., Ge, H., Giles, M., Giordano, F., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Harvey, M., Hasegawa, S., Haseler, T. O. S., Hemmick, T. K., He, X., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Imai, K., Inaba, M., Iordanova, A., Isenhower, D., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Jouan, D., Jumper, D. S., Kang, J. H., Kapukchyan, D., Karthas, S., Kawall, D., Kazantsev, A. V., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kim, C., Kim, E. -J., Kim, M., Kim, T., Kincses, D., Kingan, A., Kistenev, E., Klatsky, J., Kline, P., Koblesky, T., Kotov, D., Kovacs, L., Kudo, S., Kurgyis, B., Kurita, K., Kwon, Y., Lajoie, J. G., Larionova, D., Lebedev, A., Lee, S., Lee, S. H., Leitch, M. J., Leung, Y. H., Lewis, N. A., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Loomis, D. A., Lovasz, K., Lynch, D., Lökös, S., Majoros, T., Makdisi, Y. I., Makek, M., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mondal, M. M., Montuenga, P., Moon, T., Morrison, D. P., Muhammad, A., Mulilo, B., Murakami, T., Murata, J., Nagai, K., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakano, K., Nattrass, C., Nelson, S., Niida, T., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Patel, M., Pate, S. F., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pisani, R. P., Potekhin, M., Pun, A., Purschke, M. L., Radzevich, P. V., Ramasubramanian, N., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rolnick, S. D., Rosati, M., Rowan, Z., Runchey, J., Safonov, A. S., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sexton, A., Sharma, D., Shein, I., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shi, Z., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takahama, R., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Towell, C. L., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Wang, X. R., Wang, Z., Watanabe, Y. S., Wong, C. P., Woody, C. L., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yoon, I., Yoo, J. H., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., and Zou, L.
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High Energy Physics - Experiment - Abstract
Reported here are transverse single-spin asymmetries ($A_{N}$) in the production of charged hadrons as a function of transverse momentum ($p_T$) and Feynman-$x$ ($x_F$) in polarized $p^{\uparrow}$+$p$, $p^{\uparrow}$+Al, and $p^{\uparrow}$+Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. The measurements have been performed at forward and backward rapidity ($1.4<|\eta|<2.4$) over the range of $1.5
0$) in $p^{\uparrow}$+$p$ collisions, whereas the $p^{\uparrow}$+Al and $p^{\uparrow}$+Au results show smaller asymmetries. This finding provides new opportunities to investigate the origin of transverse single-spin asymmetries and a tool to study nuclear effects in $p$+$A$ collisions., Comment: 322 authors from 70 institutions, 13 pages, 9 figures, 13 tables, one appendix, 2015 data. v2 is version accepted for publication in Phys. Rev. D. HEPData tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html - Published
- 2023
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221. Transverse single-spin asymmetry of midrapidity $\pi^{0}$ and $\eta$ mesons in $p$+Au and $p$+Al collisions at $\sqrt{s_{_{NN}}}=$ 200 GeV
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Abdulameer, N. J., Acharya, U., Aidala, C., Akiba, Y., Alfred, M., Andrieux, V., Apadula, N., Asano, H., Azmoun, B., Babintsev, V., Bandara, N. S., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Cervantes, R., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Citron, Z., Connors, M., Corliss, R., Morales, Y. Corrales, Cronin, N., Csanád, M., Csörgő, T., Danley, T. W., Daugherity, M. S., David, G., Dean, C. T., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dion, A., Dixit, D., Doomra, V., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., En'yo, H., Enokizono, A., Esha, R., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gallus, P., Gal, C., Garg, P., Ge, H., Giles, M., Giordano, F., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Harvey, M., Hasegawa, S., Haseler, T. O. S., Hemmick, T. K., He, X., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Imai, K., Inaba, M., Iordanova, A., Isenhower, D., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Jouan, D., Jumper, D. S., Kang, J. H., Kapukchyan, D., Karthas, S., Kawall, D., Kazantsev, A. V., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kim, C., Kim, E. -J., Kim, M., Kim, T., Kincses, D., Kingan, A., Kistenev, E., Klatsky, J., Kline, P., Koblesky, T., Kotov, D., Kovacs, L., Kudo, S., Kurgyis, B., Kurita, K., Kwon, Y., Lajoie, J. G., Larionova, D., Lebedev, A., Lee, S., Lee, S. H., Leitch, M. J., Leung, Y. H., Lewis, N. A., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Loomis, D. A., Lovasz, K., Lynch, D., Lökös, S., Majoros, T., Makdisi, Y. I., Makek, M., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mondal, M. M., Montuenga, P., Moon, T., Morrison, D. P., Muhammad, A., Mulilo, B., Murakami, T., Murata, J., Nagai, K., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakano, K., Nattrass, C., Nelson, S., Niida, T., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Patel, M., Pate, S. F., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pisani, R. P., Potekhin, M., Pun, A., Purschke, M. L., Radzevich, P. V., Ramasubramanian, N., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rolnick, S. D., Rosati, M., Rowan, Z., Runchey, J., Safonov, A. S., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sexton, A., Sharma, D., Shein, I., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shi, Z., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takahama, R., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Towell, C. L., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Wang, X. R., Wang, Z., Watanabe, Y. S., Wong, C. P., Woody, C. L., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yoon, I., Yoo, J. H., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., and Zou, L.
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High Energy Physics - Experiment - Abstract
Presented are the first measurements of the transverse single-spin asymmetries ($A_N$) for neutral pions and eta mesons in $p$+Au and $p$+Al collisions at $\sqrt{s_{_{NN}}}=200$ GeV in the pseudorapidity range $|\eta|<$0.35 with the PHENIX detector at the Relativistic Heavy Ion Collider. The asymmetries are consistent with zero, similar to those for midrapidity neutral pions and eta mesons produced in $p$+$p$ collisions. These measurements show no evidence of additional effects that could potentially arise from the more complex partonic environment present in proton-nucleus collisions., Comment: 322 authors from 70 institutions, 8 pages, 2 figures, 1 table, 2015 data. v2 is version accepted for publication in Phys. Rev. D. HEPData tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html
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- 2023
222. Safe AI for health and beyond -- Monitoring to transform a health service
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Abroshan, Mahed, Burkhart, Michael, Giles, Oscar, Greenbury, Sam, Kourtzi, Zoe, Roberts, Jack, van der Schaar, Mihaela, Steyn, Jannetta S, Wilson, Alan, and Yong, May
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,I.2.1 - Abstract
Machine learning techniques are effective for building predictive models because they identify patterns in large datasets. Development of a model for complex real-life problems often stop at the point of publication, proof of concept or when made accessible through some mode of deployment. However, a model in the medical domain risks becoming obsolete as patient demographics, systems and clinical practices change. The maintenance and monitoring of predictive model performance post-publication is crucial to enable their safe and effective long-term use. We will assess the infrastructure required to monitor the outputs of a machine learning algorithm, and present two scenarios with examples of monitoring and updates of models, firstly on a breast cancer prognosis model trained on public longitudinal data, and secondly on a neurodegenerative stratification algorithm that is currently being developed and tested in clinic., Comment: 12 pages, 3 figures
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- 2023
223. A prototype hybrid prediction market for estimating replicability of published work
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Chakravorti, Tatiana, Fraleigh, Robert, Fritton, Timothy, McLaughlin, Michael, Singh, Vaibhav, Griffin, Christopher, Kwasnica, Anthony, Pennock, David, Giles, C. Lee, and Rajtmajer, Sarah
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Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
We present a prototype hybrid prediction market and demonstrate the avenue it represents for meaningful human-AI collaboration. We build on prior work proposing artificial prediction markets as a novel machine-learning algorithm. In an artificial prediction market, trained AI agents buy and sell outcomes of future events. Classification decisions can be framed as outcomes of future events, and accordingly, the price of an asset corresponding to a given classification outcome can be taken as a proxy for the confidence of the system in that decision. By embedding human participants in these markets alongside bot traders, we can bring together insights from both. In this paper, we detail pilot studies with prototype hybrid markets for the prediction of replication study outcomes. We highlight challenges and opportunities, share insights from semi-structured interviews with hybrid market participants, and outline a vision for ongoing and future work.
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- 2023
224. Associations between Non-Essential Trace Elements in Women’s Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles
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Roberto Gonzalez-Martin, Andrea Palomar, Silvia Perez-Deben, Stefania Salsano, Alicia Quiñonero, Laura Caracena, Isabel Rucandio, Rocio Fernandez-Saavedra, Rodolfo Fernandez-Martinez, Estefania Conde-Vilda, Alberto J. Quejido, Juan Giles, Carmen Vidal, Jose Bellver, and Francisco Dominguez
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non-essential trace elements ,IVF outcomes ,ovarian response ,biofluids ,ICP-MS ,Tricell DMA 80 ,Therapeutics. Pharmacology ,RM1-950 ,Toxicology. Poisons ,RA1190-1270 - Abstract
Previous studies have found inconsistent associations between heavy metals and metalloids (cadmium, lead, mercury, and arsenic), and reproductive outcomes. The biofluid concentrations of ten non-essential trace elements (Hg, Pb, As, Ba, Sr, Rb, Cs, Sn, Ni, and Co) were evaluated in 51 Spanish women undergoing ICSI, PGT-A, and SET/FET. Nine out of ten non-essential elements were detectable in follicular fluid, whole blood, and urine collected the day of vaginal oocyte retrieval (VOR) and the day of embryo transfer and then analyzed by ICP-MS or Tricell DMA-80 for mercury. Elevated mercury and strontium concentrations in follicular fluid were associated with poor ovarian response and preimplantation outcomes. Worst preimplantation outcomes were also identified in women with elevated whole-blood strontium or mercury, urinary arsenic, barium, and tin the day of VOR. High concentrations of urinary rubidium on VOR day were linked with enhanced fertilization and blastocyst development. Excessive titanium in whole blood was associated with lower odds of implantation, clinical pregnancy, and achieving a live birth in a given IVF cycle. Excessive urinary arsenic on the day of embryo transfer was associated with lower odds of live birth. Although these preliminary results need to be confirmed in larger populations, distinguishing organic and inorganic element forms, our findings show that some non-essential elements have a detrimental impact on human IVF outcomes.
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- 2024
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225. Assessment of the Nicotine Pharmacokinetics When Using Two Types of E-Cigarettes in Healthy Adults Who Smoke: Results From Two Randomized, Crossover Studies
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Yuki Dai, Giles Lesley, Larroque Sylvain, Harbo Sam, Hemsley Anthony, and Martinez Javier
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clinical study ,e-cigarette ,nicotine pharmacokinetics ,Science - Abstract
The nicotine pharmacokinetics (PK) of non-combustible tobacco and nicotine products, including e-cigarettes, have been extensively studied, with lower or similar nicotine exposure reported for most products compared with combustible cigarettes (CC). We conducted two clinical studies to evaluate nicotine PK and assess nicotine consumption when using two types of e-cigarettes with different flavor variants in U.S. healthy adults who smoke, under similar study protocols.
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- 2024
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226. Machine learning enabled classification of lung cancer cell lines co-cultured with fibroblasts with lightweight convolutional neural network for initial diagnosis
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Adam Germain, Alex Sabol, Anjani Chavali, Giles Fitzwilliams, Alexa Cooper, Sandra Khuon, Bailey Green, Calvin Kong, John Minna, and Young-Tae Kim
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Lung cancer ,Machine learning ,Co-culture ,Classification ,On-device diagnosis ,Medicine - Abstract
Abstract Background Identification of lung cancer subtypes is critical for successful treatment in patients, especially those in advanced stages. Many advanced and personal treatments require knowledge of specific mutations, as well as up- and down-regulations of genes, for effective targeting of the cancer cells. While many studies focus on individual cell structures and delve deeper into gene sequencing, the present study proposes a machine learning method for lung cancer classification based on low-magnification cancer outgrowth patterns in a 2D co-culture environment. Methods Using a magnetic well plate holder, circular pattern lung cancer cell clusters were generated among fibroblasts, and daily images were captured to monitor cancer outgrowth over a 9-day period. These outgrowth images were then augmented and used to train a convolutional neural network (CNN) model based on the lightweight TinyVGG architecture. The model was trained with pairs of classes representing three subtypes of NSCLC: A549 (adenocarcinoma), H520 (squamous cell carcinoma), and H460 (large cell carcinoma). The objective was to assess whether this lightweight machine learning model could accurately classify the three lung cancer cell lines at different stages of cancer outgrowth. Additionally, cancer outgrowth images of two patient-derived lung cancer cells, one with the KRAS oncogene and the other with the EGFR oncogene, were captured and classified using the CNN model. This demonstration aimed to investigate the translational potential of machine learning-enabled lung cancer classification. Results The lightweight CNN model achieved over 93% classification accuracy at 1 day of outgrowth among A549, H460, and H520, and reached 100% classification accuracy at 7 days of outgrowth. Additionally, the model achieved 100% classification accuracy at 4 days for patient-derived lung cancer cells. Although these cells are classified as Adenocarcinoma, their outgrowth patterns vary depending on their oncogene expressions (KRAS or EGFR). Conclusions These results demonstrate that the lightweight CNN architecture, operating locally on a laptop without network or cloud connectivity, can effectively create a machine learning-enabled model capable of accurately classifying lung cancer cell subtypes, including those derived from patients, based upon their outgrowth patterns in the presence of surrounding fibroblasts. This advancement underscores the potential of machine learning to enhance early lung cancer subtyping, offering promising avenues for improving treatment outcomes in advanced stage-patients.
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- 2024
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227. Public health management of invasive meningococcal disease outbreaks: worldwide 1973–2018, a systematic review
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Brianna R. Morello, Adriana Milazzo, Helen Siobhan Marshall, and Lynne C. Giles
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Meningococcal infections ,Meningitis ,Meningococcal ,Meningococcal vaccines ,Disease outbreaks ,Communicable disease control ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Infectious disease outbreaks are an ongoing public health concern, requiring extensive resources to prevent and manage. Invasive Meningococcal Disease (IMD) is a severe outcome of infection with Neisseria meningitidis bacteria, which can be carried and transmitted asymptomatically. IMD is not completely vaccine-preventable, presenting an ongoing risk of outbreak development. This review provides a retrospective assessment of public health management of IMD outbreaks. Methods A systematic search was performed in PubMed and EMBASE. English-language studies reporting on IMD outbreaks and associated public health response were considered eligible. Reporting on key characteristics including outbreak size, duration, location, and public health response were assessed against Strengthening the Reporting of Observational studies in Epidemiology guidelines. A summary of lessons learned and author recommendations for each article were also discussed. Results 39 eligible studies were identified, describing 35 outbreaks in seven regions. Responses to outbreaks were mostly reactive, involving whole communities over prioritising those at highest risk of transmission. Recent responses identified a need for more proactive and targeted controls. Reporting was inconsistent, with key characteristics such as outbreak size, duration, or response absent or incompletely described. Conclusion There is a need for clear, comprehensive reporting on IMD outbreaks and their public health response to inform policy and practice for subsequent outbreaks of IMD and other infectious diseases.
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- 2024
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228. Saliva-derived DNA is suitable for the detection of clonal haematopoiesis of indeterminate potential
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Robert L. O’Reilly, Jared Burke, Philip Harraka, Paul Yeh, Kerryn Howlett, Kiarash Behrouzfar, Amanda Rewse, Helen Tsimiklis, Graham G. Giles, Kristen J. Bubb, Stephen J. Nicholls, Roger L. Milne, and Melissa C. Southey
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Clonal haematopoiesis ,CHIP ,Somatic mutations ,Next generation sequencing ,Saliva ,Blood ,Medicine ,Science - Abstract
Abstract Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with many adverse health outcomes. However, further research is required to understand the critical genes and pathways relevant to CHIP subtypes, evaluate how CHIP clones evolve with time, and further advance functional characterisation and therapeutic studies. Large epidemiological studies are well placed to address these questions but often collect saliva rather than blood from participants. Paired saliva- and blood-derived DNA samples from 94 study participants were sequenced using a targeted CHIP-gene panel. The ten genes most frequently identified to carry CHIP-associated variants were analysed. Fourteen unique variants associated with CHIP, ten in DNMT3A, two in TP53 and two in TET2, were identified with a variant allele fraction (VAF) between 0.02 and 0.2 and variant depth ≥ 5 reads. Eleven of these CHIP-associated variants were detected in both the blood- and saliva-derived DNA sample. Three variants were detected in blood with a VAF > 0.02 but fell below this threshold in the paired saliva sample (VAF 0.008—0.013). Saliva-derived DNA is suitable for detecting CHIP-associated variants. Saliva can offer a cost-effective biospecimen that could both advance CHIP research and facilitate clinical translation into settings such as risk prediction, precision prevention, and treatment monitoring.
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- 2024
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229. Detection of differentially methylated CpGs between tumour and adjacent benign cells in diagnostic prostate cancer samples
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Liesel M. FitzGerald, Chol-hee Jung, Ee Ming Wong, JiHoon E. Joo, Julie K. Bassett, James G. Dowty, Xiaoyu Wang, James Y. Dai, Janet L. Stanford, Neil O’Callaghan, Tim Nottle, John Pedersen, Graham G. Giles, and Melissa C. Southey
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Medicine ,Science - Abstract
Abstract Differentially methylated CpG sites (dmCpGs) that distinguish prostate tumour from adjacent benign tissue could aid in the diagnosis and prognosis of prostate cancer. Previously, the identification of such dmCpGs has only been undertaken in radical prostatectomy (RP) samples and not primary diagnostic tumour samples (needle biopsy or transurethral resection of the prostate). We interrogated an Australian dataset comprising 125 tumour and 43 adjacent histologically benign diagnostic tissue samples, including 41 paired samples, using the Infinium Human Methylation450 BeadChip. Regression analyses of paired tumour and adjacent benign samples identified 2,386 significant dmCpGs (Bonferroni p
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- 2024
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230. Terahertz near-field microscopy of metallic circular split ring resonators with graphene in the gap
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Chiara Schiattarella, Alessandra Di Gaspare, Leonardo Viti, M. Alejandro Justo Guerrero, Lianhe H. Li, Mohammed Salih, A. Giles Davies, Edmund H. Linfield, Jincan Zhang, Hamideh Ramezani, Andrea C. Ferrari, and Miriam S. Vitiello
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Medicine ,Science - Abstract
Abstract Optical resonators are fundamental building blocks of photonic systems, enabling meta-surfaces, sensors, and transmission filters to be developed for a range of applications. Sub-wavelength size (
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- 2024
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231. Impact of RA treatment strategies on lipids and vascular inflammation in rheumatoid arthritis: a secondary analysis of the TARGET randomized active comparator trial
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Katherine P. Liao, Pamela Rist, Jon Giles, Leah Santacroce, Margery A. Connelly, Robert J. Glynn, Paul Ridker, Ahmed Tawakol, Joan Bathon, and Daniel H. Solomon
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Rheumatoid arthritis ,Lipids ,Cardiovascular disease ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Treatments for rheumatoid arthritis (RA) are associated with complex changes in lipids and lipoproteins that may impact cardiovascular (CV) risk. The objective of this study was to examine lipid and lipoprotein changes associated with two common RA treatment strategies, triple therapy or tumor necrosis factor inhibitor (TNFi), and association with CV risk. Methods In this secondary data analysis of the TARGET trial, methotrexate (MTX) inadequate responders with RA were randomized to either add sulfasalazine and hydroxychloroquine (triple therapy), or TNFi for 24-weeks. The primary trial outcome was the change in arterial inflammation measured in the carotid arteries or aorta by FDG-PET/CT at baseline and 24-weeks; this change was described as the target-to-background ratio (TBR) in the most diseased segment (MDS). Routine lipids and advanced lipoproteins were measured at baseline and 24-weeks; subjects on statin therapy at baseline were excluded. Comparisons between baseline and follow-up lipid measurements were performed within and across treatment arms, as well as change in lipids and change in MDS-TBR. Results We studied 122 participants, 61 in each treatment arm, with median age 57 years, 76% female, and 1.5 year median RA disease duration. When comparing treatment arms, triple therapy had on average a larger reduction in triglycerides (15.9 mg/dL, p = 0.01), total cholesterol to HDL-C ratio (0.29, p-value = 0.01), and LDL particle number (111.2, p = 0.02) compared to TNFi. TNFi had on average a larger increase in HDL particle number (1.6umol/L, p = 0.006). We observed no correlation between change in lipid measurements and change in MDS-TBR within and across treatment arms. Conclusions Both treatment strategies were associated with improved lipid profiles via changes in different lipids and lipoproteins. These effects had no correlation with change in CV risk as measured by vascular inflammation by FDG-PET/CT. Trial registration ClinicalTrials.gov ID NCT02374021.
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- 2024
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232. Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
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Laura Simões de Oliveira, Heather E. O’Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C. Davenport, Paul Baxter, Susana R. Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K. Osterweil, Giles E. Hardingham, Michael A. Cousin, Sumantra Chattarji, Sam A. Booker, Tim A. Benke, David J. A Wyllie, and Peter C. Kind
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CDKL5 ,rat ,hippocampus ,synaptic plasticity ,intrinsic properties ,AMPA receptor ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has been implicated in other models of monogenic forms of autism spectrum disorders and ID and is often linked to epilepsy and behavioural abnormalities. Many individuals with CDKL5 deficiency disorder (CDD) have null mutations and complete loss of CDKL5 protein, therefore in the current study we used a Cdkl5 −/y rat model to elucidate the impact of CDKL5 loss on cellular excitability and synaptic function of CA1 pyramidal cells (PCs). We hypothesised abnormal pre and/or post synaptic function and plasticity would be observed in the hippocampus of Cdkl5 −/y rats. Methods To allow cross-species comparisons of phenotypes associated with the loss of CDKL5, we generated a loss of function mutation in exon 8 of the rat Cdkl5 gene and assessed the impact of the loss of CDLK5 using a combination of extracellular and whole-cell electrophysiological recordings, biochemistry, and histology. Results Our results indicate that CA1 hippocampal long-term potentiation (LTP) is enhanced in slices prepared from juvenile, but not adult, Cdkl5 −/y rats. Enhanced LTP does not result from changes in NMDA receptor function or subunit expression as these remain unaltered throughout development. Furthermore, Ca2+ permeable AMPA receptor mediated currents are unchanged in Cdkl5 −/y rats. We observe reduced mEPSC frequency accompanied by increased spine density in basal dendrites of CA1 PCs, however we find no evidence supporting an increase in silent synapses when assessed using a minimal stimulation protocol in slices. Additionally, we found no change in paired-pulse ratio, consistent with normal release probability at Schaffer collateral to CA1 PC synapses. Conclusions Our data indicate a role for CDKL5 in hippocampal synaptic function and raise the possibility that altered intracellular signalling rather than synaptic deficits contribute to the altered plasticity. Limitations This study has focussed on the electrophysiological and anatomical properties of hippocampal CA1 PCs across early postnatal development. Studies involving other brain regions, older animals and behavioural phenotypes associated with the loss of CDKL5 are needed to understand the pathophysiology of CDD.
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- 2024
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233. Supporting Children's Mental Health in Primary Schools: A Qualitative Exploration of Educator Perspectives
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Giles-Kaye, Alison, Quach, Jon, Oberklaid, Frank, O'Connor, Meredith, Darling, Simone, Dawson, Georgia, and Connolly, Ann-Siobhan
- Abstract
Schools are often seen as a key setting for the provision of mental health support for children. This study aimed to explore the professional perspectives of primary school educators in Victoria, Australia, regarding how schools can support the mental health of their students. Semi-structured interviews and focus groups were conducted with 17 primary school educators, from four schools. Thematic analysis was used to generate themes from the data. This study indicates that educators report significant concerns about the complexities of their role and their capacity to support children's mental health due to a lack of resources, overwhelming demands, and inadequate training. Educators highlighted the importance of partnership and communication with families and of a school culture that prioritises mental health. This study provides insights into external factors that can undermine effective support of children's mental health within primary schools and indicates a need for a more integrated approach to supporting children's mental health across education and healthcare.
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- 2023
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234. 'My Name on the Door by the Professor's Name': The Process of Recruiting a Researcher with a Learning Disability at a UK University
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Anderson, Rebecca J., Keagan-Bull, Richard, Giles, Jo, and Tuffrey-Wijne, Irene
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Background: The advantages of including people with learning disabilities in research teams have been well described, but it is rare for researchers with learning disabilities to be employed at a university. This paper explores the extent to which university recruitment procedures are accessible to job applicants with learning disabilities. Methods: We present reflections on the process of recruiting a Research Assistant with a learning disability onto a university research team. The recruitment process is described from the perspectives of the employee, line manager and Human Resources representative. Findings: The recruiting manager and Human Resources representative had to make adjustments to a wide range of standard processes, including centralised online recruitment systems that were difficult to navigate, inaccessible job descriptions and difficult application forms. Finding workarounds to ensure reasonable adjustments were made was time-consuming. The employee needed significant support from within his own networks to cope with the application process and had concerns about the potential impact of fixed-term job contracts on future benefits. Despite our efforts, procedures remained difficult for the applicants to navigate. Conclusions: Employing researchers with learning disabilities is important. Fundamental changes to job application systems are required, including easy-to-understand information, alternative formats of application forms, and support available where needed. Flexibility from the Human Resources departments is key. They will need support from teams with experience working with people with learning disabilities.
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- 2023
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235. Global-Scale Processes and Effects of Magnetic Reconnection on the Geospace Environment
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Fuselier, S. A., Petrinec, S. M., Reiff, P. H., Birn, J., Baker, D. N., Cohen, I. J., Nakamura, R., Sitnov, M. I., Stephens, G. K., Hwang, J., Lavraud, B., Moore, T. E., Trattner, K. J., Giles, B. L., Gershman, D. J., Toledo-Redondo, S., and Eastwood, J. P.
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- 2024
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236. Micromobility Equity in Los Angeles: Increasing E-Scooter Deployment in Underserved Communities
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Cheung, Abraham, Murillo, Alberto, Chang, Chia, Ishikura, Masamichi, and Perloff-Giles, Nicholas
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- 2023
237. Micromobility Equity in Los Angeles
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Cheung, Abraham, Murillo, Alberto, Chang, Chia Yun, Ishikura, Masamichi, and Perloff-Giles, Nicholas
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new mobility ,equity ,equity analysis ,California ,mobility as a service ,program evaluation ,Los Angeles - Abstract
In 2019, the Los Angeles Department of Transportation’s (LADOT) micromobility program brought together the agency, scooter operators, and other stakeholders to create a holistic regulatory framework that established operational requirements and expectations to promote the safe and effective use of micromobility scooters, primarily dockless e-scooters, and e-bikes. While the program has effectively expanded the usage of micromobility and mitigated externalities associated with dockless vehicle programs, it has been less effective at ensuring access, particularly in underserved neighborhoods such as the Equity-Focused Mobility Development Districts. In a mixed-methods approach, we combine micromobility data from LADOT, interviews with private operators and community-based organizations, and case studies of micromobility equity programs in other US cities to inform our three policy recommendations for LADOT. The three key policy levers are a reduction in the number of operators allowed within the program, strengthened outreach requirements with enforcement from LADOT, and a modification to the penalty schedule that does not deter deployment in the San Fernando Valley. These policies would create more favorable market conditions for increasing operator deployment in the equity zones while advancing LADOT’s goal of improving access to shared mobility.
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- 2023
238. Author Correction: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer
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Rahman, Razia, Rahaman, Muhammed H., Hanson, Adrienne R., Choo, Nicholas, Xie, Jianling, Townley, Scott L., Shrestha, Raj, Hassankhani, Ramin, Islam, Saiful, Ramm, Susanne, Simpson, Kaylene J., Risbridger, Gail P., Best, Giles, Centenera, Margaret M., Balk, Steven P., Kichenadasse, Ganessan, Taylor, Renea A., Butler, Lisa M., Tilley, Wayne D., Conn, Simon J., Lawrence, Mitchell G., Wang, Shudong, and Selth, Luke A.
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- 2024
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239. Pre-Kindergarten Teachers' Perceptions of Social and Emotional Learning
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Liesch, Hillary Polchow, Morrison, Karen, and Giles, Rebecca M.
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Recognition of social and emotional learning (SEL), as an essential educational component, has increased in recent years, and early childhood educators' perceptions of SEL are likely to impact the delivery, evaluation, and outcomes of SEL opportunities for young children. The purpose of this pilot study was to investigate SEL perceptions of prekindergarten teachers in an American urban, public preschool serving predominantly Black students. Participant (n=22) responses to the Teacher Social and Emotional Learning Beliefs Scale (Brackett et al., 2012) were used to calculate mean scores for the domains of comfort, commitment, and culture, which were analyzed in relationship to the independent variables of teacher position (lead or auxiliary), level of education (associate degree, bachelor's degree, or graduate degree), and years of prekindergarten teaching experience (0-20 years and more than 20 years). While results were statistically non-significant, findings of the current pilot study have important and practical implications for implementing SEL in prekindergarten. Auxiliary teachers scored slightly lower in commitment and comfort domain than lead teachers, and teachers with a bachelor's degree scored highest on the comfort domain. Interestingly, experienced teachers (more than 20 years) did not show a notable difference from those who have been teaching prekindergarten for much less time. Findings suggest that regardless of position and educational level, both veteran and novice early childhood teachers could benefit from explicit SEL training and adequate time and opportunity to become confident in providing effective social and emotional learning in their early childhood classrooms. Further research is needed to examine the effects of SEL training and coaching for prekindergarten teachers on the SEL of young children.
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- 2022
240. The Good Game: Developing Feedback Skills through Action Learning
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Dieckman, Andrea, Nelson, Eric, Luechtefeld, Ray, and Giles, Garrett
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Students, especially those from recent generations, typically encounter difficulties providing and receiving feedback. Hence approaches to teach students feedback skills are valuable. This article explores perspectives related to learning feedback by (a) examining the process of feedback, (b) showing how Action Learning as a pedagogical component is supportive of developing feedback skills, (c) explaining a student-led game, "The Good Game," as a tool for learning feedback, and (d) discussing issues and factors related to developing feedback skills among recent generations.
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- 2022
241. Social Media Practices of School Administrators: The Time Is Now
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Bowman, Heather, Giles, Michelle, Orange, Amy, Decman, John, and Willis, Jana M.
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The educational disruption caused by COVID-19 increased awareness of the value of organizational resiliency/sustainability and the critical need for administrators to provide timely communication among all stakeholders. If preparation programs are to provide administrators with the skills and knowledge to effectively use social media as a communication tool, we must explore the practices and perceptions of school administrators' use of social media to communicate with stakeholders and to identify their recommended social media communication practices. The "Social Media as a Tool to Effectively Communicate with Stakeholders Survey" and interviews were used for data collection. Findings are focused on comfort levels, perceived effectiveness, benefits, concerns, and recommended practices reported by the school administrators who participated in the study. While, social media was found to be an effective communication tool that can promote and support positive public relations, there were noted gaps in self-efficacy and best practices of the reporting administrators. Research literature, preparation programs, and practicing administrators will equally benefit from the outcomes of this study.
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- 2022
242. Higher Education Outreach via Student Organizations: Students Leading the Way
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Jones, Jennifer A. and Giles, Elaine H.
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Higher education outreach and engagement often occurs through student volunteering. Student organizations are one understudied and undertapped mechanism that facilitates such connections. We examined the experience of student leaders of student organizations that promoted volunteerism among their members. The mixed-methods study included a survey (n = 26) and follow-up interviews (n = 5). We found that participants' organizations were highly involved in the community and that participants gained valuable leadership skills in this role. We also found that participants had relatively little insight concerning the community partners' experience of the collaboration. We identified sampling as a unique challenge for this theoretical population and, in the discussion, provide considerations and recommendations for future scholars.
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- 2022
243. Summaries as Captions: Generating Figure Captions for Scientific Documents with Automated Text Summarization
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Huang, Chieh-Yang, Hsu, Ting-Yao, Rossi, Ryan, Nenkova, Ani, Kim, Sungchul, Chan, Gromit Yeuk-Yin, Koh, Eunyee, Giles, Clyde Lee, and Huang, Ting-Hao 'Kenneth'
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Computer Science - Computation and Language - Abstract
Good figure captions help paper readers understand complex scientific figures. Unfortunately, even published papers often have poorly written captions. Automatic caption generation could aid paper writers by providing good starting captions that can be refined for better quality. Prior work often treated figure caption generation as a vision-to-language task. In this paper, we show that it can be more effectively tackled as a text summarization task in scientific documents. We fine-tuned PEGASUS, a pre-trained abstractive summarization model, to specifically summarize figure-referencing paragraphs (e.g., "Figure 3 shows...") into figure captions. Experiments on large-scale arXiv figures show that our method outperforms prior vision methods in both automatic and human evaluations. We further conducted an in-depth investigation focused on two key challenges: (i) the common presence of low-quality author-written captions and (ii) the lack of clear standards for good captions. Our code and data are available at: https://github.com/Crowd-AI-Lab/Generating-Figure-Captions-as-a-Text-Summarization-Task., Comment: Accepted by INLG-2023
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- 2023
244. Enhanced C$_2$H$_2$ absorption within Jupiter's southern auroral oval from Juno UVS observations
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Giles, Rohini S., Hue, Vincent, Greathouse, Thomas K., Gladstone, G. Randall, Kammer, Joshua A., Versteeg, Maarten H., Bonfond, Bertrand, Grodent, Denis G., Gérard, Jean-Claude, Sinclair, James A., Bolton, Scott J., and Levin, Steven M.
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Space Physics - Abstract
Reflected sunlight observations from the Ultraviolet Spectrograph (UVS) on the Juno spacecraft were used to study the distribution of acetylene (C$_2$H$_2$) at Jupiter's south pole. We find that the shape of the C$_2$H$_2$ absorption feature varies significantly across the polar region, and this can be used to infer spatial variability in the C$_2$H$_2$ abundance. There is a localized region of enhanced C$_2$H$_2$ absorption which coincides with the location of Jupiter's southern polar aurora; the C$_2$H$_2$ abundance poleward of the auroral oval is a factor of 3 higher than adjacent quiescent, non-auroral longitudes. This builds on previous infrared studies which found enhanced C$_2$H$_2$ abundances within the northern auroral oval. This suggests that Jupiter's upper-atmosphere chemistry is being strongly influenced by the influx of charged auroral particles and demonstrates the necessity of developing ion-neutral photochemical models of Jupiter's polar regions., Comment: Accepted in JGR: Planets
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- 2023
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245. Relaxation of the turbulent magnetosheath
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Pecora, Francesco, Yang, Yan, Chasapis, Alexandros, Servidio, Sergio, Cuesta, Manuel, Roy, Sohom, Chhiber, Rohit, Bandyopadhyay, Riddhi, Gershman, D. J., Giles, B. L., Burch, J. L., and Matthaeus, William H.
- Subjects
Physics - Fluid Dynamics ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics ,Physics - Space Physics - Abstract
In turbulence, nonlinear terms drive energy transfer from large-scale eddies into small scales through the so-called energy cascade. Turbulence often relaxes toward states that minimize energy; typically these states are considered globally. However, turbulence can also relax toward local quasi-equilibrium states, creating patches or cells where the magnitude of nonlinearity is reduced and energy cascade is impaired. We show, for the first time, compelling observational evidence that this ``cellularization'' of turbulence can occur due to local relaxation in a strongly turbulent natural environment such as the Earth's magnetosheath.
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- 2023
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246. ACL-Fig: A Dataset for Scientific Figure Classification
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Karishma, Zeba, Rohatgi, Shaurya, Puranik, Kavya Shrinivas, Wu, Jian, and Giles, C. Lee
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Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Digital Libraries - Abstract
Most existing large-scale academic search engines are built to retrieve text-based information. However, there are no large-scale retrieval services for scientific figures and tables. One challenge for such services is understanding scientific figures' semantics, such as their types and purposes. A key obstacle is the need for datasets containing annotated scientific figures and tables, which can then be used for classification, question-answering, and auto-captioning. Here, we develop a pipeline that extracts figures and tables from the scientific literature and a deep-learning-based framework that classifies scientific figures using visual features. Using this pipeline, we built the first large-scale automatically annotated corpus, ACL-Fig, consisting of 112,052 scientific figures extracted from ~56K research papers in the ACL Anthology. The ACL-Fig-Pilot dataset contains 1,671 manually labeled scientific figures belonging to 19 categories. The dataset is accessible at https://huggingface.co/datasets/citeseerx/ACL-fig under a CC BY-NC license., Comment: 6 pages, 4 figures, accepted by the AAAI-23 Workshop on Scientific Document Understanding
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- 2023
247. Individualized prescriptive inference in ischaemic stroke
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Giles, Dominic, Gray, Robert, Foulon, Chris, Pombo, Guilherme, Xu, Tianbo, Jäger, H. Rolf, Cardoso, Jorge, Ourselin, Sebastien, Rees, Geraint, Jha, Ashwani, and Nachev, Parashkev
- Subjects
Quantitative Biology - Quantitative Methods - Abstract
The gold standard in the treatment of ischaemic stroke is set by evidence from randomized controlled trials. Yet the manifest complexity of the brain's functional, connective, and vascular architectures introduces heterogeneity in treatment susceptibility that violates the underlying statistical premisses, potentially leading to substantial errors at both individual and population levels. The counterfactual nature of therapeutic inference has made quantifying the impact of this defect difficult. Combining large-scale meta-analytic connective, functional, genetic expression, and receptor distribution data with high-resolution maps of 4 119 acute ischaemic lesions, here we conduct a comprehensive series of semi-synthetic virtual interventional trials, quantifying the fidelity of the traditional approach in inferring individual treatment effects against biologically plausible, empirically informed ground truths, across 103 628 800 distinct simulations. Combining deep generative models expressive enough to capture the observed lesion heterogeneity with flexible causal modelling, we find that the richness of the lesion representation is decisive in determining individual-level fidelity, even where freedom from treatment allocation bias cannot be guaranteed. Our results indicate that complex modelling with richly represented lesion data is critical to individualized prescriptive inference in ischaemic stroke., Comment: 131 pages
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- 2023
248. Application of Inferno to a Top Pair Cross Section Measurement with CMS Open Data
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Layer, Lukas, Dorigo, Tommaso, and Strong, Giles C.
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High Energy Physics - Experiment ,Physics - Data Analysis, Statistics and Probability - Abstract
In recent years novel inference techniques have been developed based on the construction of non-linear summary statistics with neural networks by minimising inferencemotivated losses. One such technique is inferno (P. de Castro and T. Dorigo, Comp. Phys. Comm. 244 (2019) 170) which was shown on toy problems to outperform classical summary statistics for the problem of confidence interval estimation in the presence of nuisance parameters. In order to test and benchmark the algorithm in a real world application, a full, systematics-dominated analysis produced by the CMS experiment, "Measurement of the top-antitop production cross section in the tau+jets channel in pp collisions at sqrt(s) = 7 TeV" (CMS Collaboration, The European Physical Journal C, 2013) is reproduced with CMS Open Data. The application of the inferno-powered neural network architecture to this analysis demonstrates the potential to reduce the impact of systematic uncertainties in real LHC analyses. This work also exemplifies the extent to which LHC analyses can be reproduced with open data., Comment: 19 pages, 8 figures
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- 2023
249. Efficient Risk Estimation for the Credit Valuation Adjustment
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Giles, Michael B., Haji-Ali, Abdul-Lateef, and Spence, Jonathan
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Quantitative Finance - Computational Finance ,65C05, 62P05 - Abstract
The valuation of over-the-counter derivatives is subject to a series of valuation adjustments known as xVA, which pose additional risks for financial institutions. Associated risk measures, such as the value-at-risk of an underlying valuation adjustment, play an important role in managing these risks. Monte Carlo methods are often regarded as inefficient for computing such measures. As an example, we consider the value-at-risk of the Credit Valuation Adjustment (CVA-VaR), which can be expressed using a triple nested expectation. Traditional Monte Carlo methods are often inefficient at handling several nested expectations. Utilising recent developments in multilevel nested simulation for probabilities, we construct a hierarchical estimator of the CVA-VaR which reduces the computational complexity by 3 orders of magnitude compared to standard Monte Carlo., Comment: 35 pages, 2 figures
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- 2023
250. SOFIA and ALMA Investigate Magnetic Fields and Gas Structures in Massive Star Formation: The Case of the Masquerading Monster in BYF 73
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Barnes, Peter J., Ryder, Stuart D., Novak, Giles, Crutcher, Richard M., Fissel, Laura M., Pitts, Rebecca L., and Schap III, William J.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present SOFIA+ALMA continuum and spectral-line polarisation data on the massive molecular cloud BYF 73, revealing important details about the magnetic field morphology, gas structures, and energetics in this unusual massive star formation laboratory. The 154$\mu$m HAWC+ polarisation map finds a highly organised magnetic field in the densest, inner 0.55$\times$0.40 pc portion of the cloud, compared to an unremarkable morphology in the cloud's outer layers. The 3mm continuum ALMA polarisation data reveal several more structures in the inner domain, including a pc-long, $\sim$500 M$_{\odot}$ "Streamer" around the central massive protostellar object MIR 2, with magnetic fields mostly parallel to the east-west Streamer but oriented north-south across MIR 2. The magnetic field orientation changes from mostly parallel to the column density structures to mostly perpendicular, at thresholds $N_{\rm crit}$ = 6.6$\times$10$^{26}$ m$^{-2}$, $n_{\rm crit}$ = 2.5$\times$10$^{11}$ m$^{-3}$, and $B_{\rm crit}$ = 42$\pm$7 nT. ALMA also mapped Goldreich-Kylafis polarisation in $^{12}$CO across the cloud, which traces in both total intensity and polarised flux, a powerful bipolar outflow from MIR 2 that interacts strongly with the Streamer. The magnetic field is also strongly aligned along the outflow direction; energetically, it may dominate the outflow near MIR 2, comprising rare evidence for a magnetocentrifugal origin to such outflows. A portion of the Streamer may be in Keplerian rotation around MIR 2, implying a gravitating mass 1350$\pm$50 M$_{\odot}$ for the protostar+disk+envelope; alternatively, these kinematics can be explained by gas in free fall towards a 950$\pm$35 M$_{\odot}$ object. The high accretion rate onto MIR 2 apparently occurs through the Streamer/disk, and could account for $\sim$33% of MIR 2's total luminosity via gravitational energy release., Comment: 33 pages, 32 figures, accepted by ApJ. Line-Integral Convolution (LIC) images and movie versions of Figures 3b, 7, and 29 are available at https://gemelli.spacescience.org/~pbarnes/research/champ/papers/
- Published
- 2023
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