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Objectives: This study assessed the effects of two remineralizing agents namely MI Paste Plus containing casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACFP) and Remin Pro containing hydroxyapatite, fluoride and xylitol (HFX) with/without erbium-doped yttrium aluminium garnet (Er:YAG) and CO2 laser irradiation on demineralized enamel microhardness. Materials and Methods: In this in vitro study, 70 sound human premolars were mesiodistally sectioned, demineralized at a pH of 4.6 for 8 hours, and randomly divided into 7 remineralization groups (n=10): of (I) MI Paste Plus (CPP-ACFP), (II) Remin Pro (HFX), (III) MI Paste Plus+CO2 laser (0.7 W power, 50 Hz), (IV) Remin Pro+CO2 laser, (V) MI Paste Plus+Er:YAG laser (1 W power, 10 Hz), (VI) Remin Pro+Er:YAG laser, and (VII) negative control. The Vickers hardness number of specimens was then measured. The groups were compared by one-way ANOVA and Tukey’s test (α=0.05). Results: The mean microhardness was 319.8±49.9, 325.3±44.6, 359.4±35.7, 296.4±33.7, 319.9±58.1, 358.9±28.4, and 240.0±41.6 kg/mm2 in groups 1 to 7, respectively. The difference in microhardness was significant among the groups (P0.05). Conclusion: Both Remin Pro (containing HFX) and MI Paste Plus (containing CPP-ACFP) can cause enamel remineralization. MI Paste Plus+CO2 laser irradiation and Remin Pro+Er:YAG laser irradiation were significantly more effective than the application of each remineralizing agent alone.

BackgroundIran is facing an epidemiological transition with the increasing burden of non-communicable diseases, such as obesity-related disorders and cardiovascular diseases (CVDs). We conducted a population-based prospective study to assess the prevalence and incidence rates of CVDs and obesity-related metabolic disorders and to evaluate the predictive ability of various CVD risk assessment tools in an Iranian population.MethodWe enrolled 5,799 participants in Amol, a city in northern Iran, in 2009–2010 and carried out the first repeated measurement (RM) after seven years (2016–2017). For all participants, demographic, anthropometric, laboratory, hepatobiliary imaging, and electrocardiography data have been collected in the enrollment and the RM. After enrollment, all participants have been and will be followed up annually for 20 years, both actively and passively.ResultsWe adopted a multidisciplinary approach to overcome barriers to participation and achieved a 7-year follow-up success rate of 93.0% with an active follow-up of 5,394 participants aged 18–90 years. In the RM, about 64.0% of men and 81.2% of women were obese or overweight. In 2017, about 16.2% and 5.2% of men had moderate or severe non-alcoholic fatty liver disease, while women had a significantly higher prevalence of metabolic syndrome (35.9%), and type 2 diabetes mellitus (20.9%) than men. Of 160 deceased participants, 69 cases (43.1%) died due to CVDs over seven years.ConclusionThe most prevalent obesity-related chronic disease in the study was metabolic syndrome. Across the enrollment and RM phases, women exhibited a higher prevalence of obesity-related metabolic disorders. Focusing on obesity-related metabolic disorders in a population not represented previously and a multidisciplinary approach for enrolling and following up were the strengths of this study. The study outcomes offer an evidence base for future research and inform policies regarding non-communicable diseases in northern Iran.

Plant-based hard capsules have gained considerable attention because of their great properties. Accordingly, designing and developing of these kinds of capsules will be a difficult task. Herein, an innovative pullulan-based hard capsule formulation was prepared for the first time. A series of characterization approaches, including Fourier transform infrared, field emission scanning electron microscope, and rheology analysis, were utilized to figure out the straightforward preparation of a designed hard capsule. Many tests and experiments were performed to achieve the optimum capsule formulation. Based on the obtained results, specifications such as uniform downfall and non-desirable adhesion, and other ideal characteristics of the capsule display the critical function. The gelling promoter of divalent cationic salts is more beneficial than its single-valent counterparts. With respect to the key role of gelling promoter, the presence of chosen MgSO4.7H2O salt and the source of selected carrageenan are important parameters to achieve optimal formulation. Moreover, field emission scanning electron microscope images illustrate that the weight ratio of 3.5 (gelling agent to salt) displays uniform surface morphology without any impurities or other foreign materials. Likewise, the outcomes of the rheology test also illustrated that the weight ratio of 3.5 is preferable. Considering the different weight ratios, the benefits of a weight ratio of 3.5 outweigh the other investigated ratios. Overall, the current research addresses substantial information about developing pullulan-based hard capsules for target usage.

Drought is one of the serious abiotic factors influencing crop production such as coriander. Development of tolerant genotypes is prevented by the lack of effective selection criterion. Objectives of this study were evaluation of coriander accessions for water deficit stress and introduce a new multivariate method to select drought tolerant genotypes. For investigation of 19 traits, 16 Iranian endemic coriander genotypes were grown in a glasshouse under control and water deficit stress conditions. Shoot dry weight (SDW), fruit weight per plant (FWPP), fruit number per plant (FNPP) and umbel number per plant (UNPP) were decreased (Susceptibility Index>38%) under water deficit stress condition compared with the control condition. While the mean values of root dry weight (RDW) and root to shoot ratio (RTSR) were increased 1.49% and 97.33% under water stress condition, respectively. Because of high inheritance, high expected genetic gain, high genotypic correlation with together, well response to drought stress and high explanation of FWPP variation in regression model, the FWPP, branch number per plant (BNPP), FNPP and SPAD chlorophyll content in grain filing stage (SCCIGFS) traits were selected to screen coriander genotypes for drought tolerance in coriander. The principal component analysis mediated method (PCAMM) indicated as comprehensive criterion to screen drought tolerant genotypes. This method was highly heritabl, able to separate the Fernandez described A, B, C and D groups, no multicollinear and using multiple drought tolerance related traits. The PCAMM results showed that G13, G16, G2 and G12 genotypes belonged to Fernandez described A, B, C and D groups, respectively.

Colorectal cancer (CRC) is the second most cancer-related death worldwide. In recent years, probiotics have been used to reduce the potential risks of CRC and tumors with various mechanisms. Different bacteria have been suggested to play different roles in the progression, prevention, or treatment of CRC. Akkermansia muciniphila is considered a next-generation probiotic for preventing and treating some diseases. Therefore, in this review article, we aimed to describe and discuss different mechanisms of A. muciniphila as an intestinal microbiota or probiotic in CRC. Some studies suggested that the abundance of A. muciniphila was higher or increased in CRC patients compared to healthy individuals. However, the decreased abundance of A. muciniphila was associated with severe symptoms of CRC, indicating that A. muciniphila did not play a role in the development of CRC. In addition, A. muciniphila administration elevates gene expression of proliferation-associated molecules such as S100A9, Dbf4, and Snrpd1, or markers for cell proliferation. Some other studies suggested that inflammation and tumorigenesis in the intestine might promoted by A. muciniphila. Overall, the role of A. muciniphila in CRC development or inhibition is still unclear and controversial. Various methods of bacterial supplementation, such as viability, bacterial number, and abundance, could all influence the colonization effect of A. muciniphila administration and CRC progression. Overall, A. mucinipila has been revealed to modulate the therapeutic potential of immune checkpoint inhibitors. Preliminary human data propose that oral consumption of A. muciniphila is safe, but its efficacy needs to be confirmed in more human clinical studies.

Brucellosis is recognized as a significant global zoonotic infection that disproportionately affects low-income settings. A community cross-sectional survey was carried out in a rural setting of northwest Iran between February and May 2023. Rural individuals were interviewed according to a questionnaire with questions about demographic characteristics, knowledge, attitudes, and practices relating to human brucellosis. We employed descriptive statistics to study knowledge, attitudes, and practice patterns. In addition, we applied a multivariable logistic regression model to assess potential predictors of knowledge, attitudes, and practice related to brucellosis using odds ratios and 95% confidence intervals. Among 700 participants, 91.1% were aware of brucellosis, and 85.7% identified cows, sheep, and goats as primary transmission sources. 75.6% and 78.7% recognized transmission risks via unpasteurized and raw milk products. 60.5% understood the benefits of boiling milk and using gloves. Attitudinally, 64.3% perceived higher risk for livestock owners and supported practices like milk pasteurization (70.5%), protective gear (84.4%), handwashing (92.2%), and animal vaccination (71.0%). 90% expressed a need for more information. In practice, 44.8% exclusively consumed boiled and pasteurized milk, 37.8% consumed fresh cheese, and 92.2% solely consumed thoroughly cooked animal meat. Logistic regression revealed that higher education and no prior history of the disease correlated with good knowledge and attitudes, while older participants displayed inappropriate practices compared to their younger counterparts. This study highlights the reasonably high awareness of brucellosis, particularly regarding transmission sources and preventive measures. However, the gaps in knowledge, attitudes, and practices still exist, with education level emerging as a significant factor. To improve prevention practices, tailored interventions addressing age-related disparities are necessary.

Polyamines (PAs) are small molecules that exist in all living organisms. They play a crucial role in various physiological processes in plants, including growth, development and responses to stress. Cold stress is one of the major abiotic stresses that has a negative effect on the growth, development and productivity of plants. In the present study, exogenous PAs (Spd, Put and distilled water as control) were efficiently used in mitigating of stress effects in two contrasting wheats cultivars (‘Mihan’ and ‘Rakhshan’) grown under cold conditions. Shoot and root dry weight, chlorophyll, carotenoid, proline contents, catalase and ascorbate peroxidase activities were improved by PA application (10 mg L−1 foliar spray) in the cold-stressed plants. The gene expression analysis with RT-qPCR showed transcriptional variation of selected genes in response to cold condition and PAs. Under cold condition the expression levels of genes responsible for the synthesis (TaADC, TaSAMDC, TaSPDS) and catabolism (TaPAO11–7B TaPAO11–7D) increased in both cultivars, but at higher level in the tolerant one. These results reveal a significant role of PAs under cold acclimation in wheat leaves.

Abstract Background Control system design for a microprocessor-controlled hip–knee–ankle–foot (HKAF) prosthesis is a challenge since hip disarticulation amputees lack the entire leg and, therefore, only have pelvis movement as user-guided input. This research proposes a method for determining hip joint angles from pelvis movement in a control system for the next generation of powered prostheses. Method Three-dimensional pelvic motion and stance time of 10 transfemoral (TF) prosthetic users were used to identify important features and to develop an algorithm to calculate hip angles from pelvis movement based on correlation and linear regression results. The algorithm was then applied to a separate (independent) TF group to validate algorithm performance. Results The proposed algorithm calculated viable hip angles during walking by utilizing pelvic rotation, pelvic tilt, and stance time. Small angular differences were found between the algorithm results and motion capture data. The greatest difference was for hip maximum extension angle (2.5 ± 2.0°). Conclusions Since differences between algorithm output and motion data were within participant standard deviations, the developed algorithm could be used to determine the desired hip angle from pelvis movements. This study will aid the future development of gait control systems for new active HKAF prostheses.

Abstract According to a paper released and submitted to WHO by IARC scientists, there would be 905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths expected as a direct result. Hepatitis B virus (HBV) hepatitis C virus (HCV), and hepatitis D virus (HDV) all play critical roles in the pathogenesis of hepatocellular carcinoma (HCC), despite the rising prevalence of HCC due to non-infectious causes. Liver cirrhosis and HCC are devastating consequences of HBV and HCV infections, which are widespread worldwide. Associated with a high mortality rate, these infections cause about 1.3 million deaths annually and are the primary cause of HCC globally. In addition to causing insertional mutations due to viral gene integration, epigenetic alterations and inducing chronic immunological dysfunction are all methods by which these viruses turn hepatocytes into cancerous ones. While expanding our knowledge of the illness, identifying these pathways also give possibilities for novel diagnostic and treatment methods. Nuclear factor erythroid 2-related factor 2 (NRF2) activation is gaining popularity as a treatment option for oxidative stress (OS), inflammation, and metabolic abnormalities. Numerous studies have shown that elevated Nrf2 expression is linked to HCC, providing more evidence that Nrf2 is a critical factor in HCC. This aberrant Nrf2 signaling drives cell proliferation, initiates angiogenesis and invasion, and imparts drug resistance. As a result, this master regulator may be a promising treatment target for HCC. In addition, the activation of Nrf2 is a common viral effect that contributes to the pathogenesis, development, and chronicity of virus infection. However, certain viruses suppress Nrf2 activity, which is helpful to the virus in maintaining cellular homeostasis. In this paper, we discussed the influence of Nrf2 deregulation on the viral life cycle and the pathogenesis associated with HBV and HCV. We summed up the mechanisms for the modulation of Nrf2 that are deregulated by these viruses. Moreover, we describe the molecular mechanism by which Nrf2 is modulated in liver cancer, liver cancer stem cells (LCSCs), and liver cancer caused by HBV and HCV. Video Abstract

Abstract Carcinoma of the lung is among the most common types of cancer globally. Concerning its histology, it is categorized as a non-small cell carcinoma (NSCLC) and a small cell cancer (SCLC) subtype. MicroRNAs (miRNAs) are a member of non-coding RNA whose nucleotides range from 19 to 25. They are known to be critical regulators of cancer via epigenetic control of oncogenes expression and by regulating tumor suppressor genes. miRNAs have an essential function in a tumorous microenvironment via modulating cancer cell growth, metastasis, angiogenesis, metabolism, and apoptosis. Moreover, a wide range of information produced via several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, and predictive marker functions in different types of lung malignancy. miRNA mimics or anti-miRNAs can be transferred into a lung cancer cell, with possible curative implications. As a result, miRNAs hold promise as targets for lung cancer treatment and detection. In this study, we investigate the different functions of various miRNAs in different types of lung malignancy, which have been achieved in recent years that show the lung cancer-associated regulation of miRNAs expression, concerning their function in lung cancer beginning, development, and resistance to chemotherapy, also the probability to utilize miRNAs as predictive biomarkers for therapy reaction. Graphical abstract

Background & Aim: Patients undergoing hemodialysis commonly experience discomfort due to the insertion of needles into their arteriovenous fistula. The aim of the study was to compare the effect of EMLA ointment and lidocaine spray, along with the use of rhythmic breathing on the intensity of pain caused by the insertion of needles in the arteriovenous fistula among hemodialysis patients. Methods & Materials: This study was a randomized clinical trial conducted on a total of 80 patients who were referred to Imam Khomeini and Golestan hospitals in Ahvaz in 2022. The numerical pain measurement scale was used as the data collection tool. The participants were selected using the convenience sampling method and then randomly allocated into two groups. In the EMLA ointment group (n=39), a total of 2 grams of EMLA ointment was applied to the target area 60 minutes before the hemodialysis procedure. In the lidocaine spray group with rhythmic breathing (n=41), 2 puffs of lidocaine spray were administered along with rhythmic breathing 5 minutes prior to needle insertion. The pain intensity was then measured and recorded. The collected data was analyzed using descriptive and inferential statistics in SPSS version 20, with a significance level set at 0.05. Results: The group receiving EMLA ointment and the group receiving lidocaine spray, with rhythmic breathing had mean pain scores of 1.95±1.09 and 2.12±1.10, respectively. Although the mean pain score in the EMLA ointment group was lower than that in the lidocaine spray group with rhythmic breathing, the difference was not statistically significant (P=0.479). Conclusion: The findings of this study indicate that both EMLA ointment and lidocaine spray, along with the use of rhythmic breathing, have comparable efficacy in reducing pain among hemodialysis patients. Therefore, considering the patient's condition, the utilization of either of these methods is recommended. Clinical trial registry: IRCT20220512054826N1

Abstract This study was conducted to evaluate the properties of lightweight sandwich panels made from low diameter bamboo particles, Phyllostachys Bambusides collected from Gilan province, Iran, as core layer, combined with thin wall bamboo strips as faces. The effects of three individual variables such as density of core layer (350–550 kg/m3), resin consumption in core layer (7.5–9.5%) and resin consumption in faces (175–275 g/m2) on some important physical, mechanical and thermos-acoustic properties of the panels were investigated. Response surface methodology was used to statistically analyse the results and optimization process. The average values for the mechanical properties of the sandwich panels were obtained as 17.16 MPa, 5669 MPa, 0.02 MPa, 17.60 MPa, 1.83 MPa, 0.03 MPa, and 913.3 MPA for modulus of rupture, modulus of elasticity, internal bonding, compression strength parallel to face grain, compression strength perpendicular to face grain, shear strength, and screw holding, respectively. Finally, thermal conductivity and noise reduction coefficient of the panels were respectively gained as 0.01 W/mk and 0.31. The results of technical and thermo- acoustic properties of the panels showed that the light weight sandwich panels from bamboo residues would be a suitable and sustainable alternative as an insulation material for sustainable and green construction.

Abstract Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including the human papillomaviruses, hepatitis B virus, Epstein–Barr virus, and hepatitis C virus, promote the aggressiveness of cancer by encouraging the development of CSC features. Therefore, a better method for the targeted elimination of CSCs and knowledge of their regulatory mechanisms in human carcinogenesis may lead to the development of a future tool for the management and treatment of cancer. Oncolytic viruses (OVs), which include the herpes virus, adenovirus, vaccinia, and reovirus, are also a new class of cancer therapeutics that have favorable properties such as selective replication in tumor cells, delivery of numerous eukaryotic transgene payloads, induction of immunogenic cell death and promotion of antitumor immunity, as well as a tolerable safety profile that essentially differs from that of other cancer therapeutics. The effects of viral infection on the development of CSCs and the suppression of CSCs by OV therapy were examined in this paper. The purpose of this review is to investigate the dual role of viruses in CSCs (oncolytic virotherapy and viral oncogenes). Graphical Abstract

Abstract Viral infections in humans are responsible for fatalities worldwide and contribute to the incidence of various human ailments. Controllable targeted medicine delivery against many illnesses, including viral infection, may be significantly aided by using bacteria and bacteria-derived products. They may accumulate in diseased tissues despite physical obstacles, where they can launch antiviral immunity. The ability to genetically and chemically modify them means that vaccinations against viral infections may be manufactured and delivered to affected tissues more safely and effectively. The objective of this study is to provide an overview of the latest advancements in the field of utilizing bacteria and bacterial derivatives as carriers for administering medication to treat viral diseases such as SARS-CoV-2, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, human papillomavirus, influenza, and Ebola virus. Graphical Abstract

Background: Curative resection with adequate margins is a treatment principle in gastroesophageal junction cancers. There is still no comprehensive agreement on the length of the negative proximal margin after total gastrectomy in Siewert II and III tumors. Extending the proximal negative margin in this anatomical region is very difficult in some cases and can cause more complications for the patients. This study aimed to investigate the influence of the negative proximal margin length on the local anastomotic recurrence in gastroesophageal junction (GEJ) adenocarcinoma in a referral cancer center in Iran.Methods: In a prospective cross-sectional study, 35 patients with GEJ Sievert II and III adenocarcinomas who underwent total radical gastrectomy from 2017 to 2020 were included. Proximal margin length was measured immediately after resection in the operation room. Then, patients were evaluated for local recurrence at the anastomosis site after two years by endoscopic examination. The relationship between negative proximal margin length, local recurrence rate, and overall survival was evaluated.Results: From 35 patients 29 (82.9%) cases had negative proximal margins, and 6 (17.1%) cases had positive proximal margins. The least negative proximal margin length was 0.1 cm, and the most were 5 cm. The mean margin was 2±1.6 cm. Based on the endoscopic and pathologic findings, the local recurrence at the anastomosis site was 20% in two years of follow-up. The incidence of local tumor recurrence was higher in patients with positive margins versus patients with negative ones (11.4% vs. 8.6%, P=0.007). There was no significant relationship between the negative proximal margin length and the incidence of local anastomotic recurrence.Conclusion: According to our findings, the length of the negative proximal margin has no effect on the rate of local recurrence at the anastomosis site, however it is suggested to reach the negative proximal margin in all tumor stages in total gastrectomy for Siewert II and III gastric cardia tumors.

The purpose of this article is to analyze the effect of the heterogeneous behavior of investors in the housing sector on housing prices and inflation in Iran during the period 2001:3 - 2020:3. The threshold effects of behavioral variables on housing prices and the effect of housing prices on inflation using smooth transition regression method (STR) is estimated. Then, using Sobel's statistic. The results of the estimation of house prices show that Herding behavior has a positive effect on housing prices in the first regime and the second regime. Overconfidence in the first regime was ineffective on housing prices, but in the second regime, it had a positive and significant effect. The results of estimating the inflation model also indicated that there are two limit regimes for the inflation function. Housing prices had a positive effect on the inflation rate in the first and second regimes. The calculation of the Sobel statistic also indicates the confirmation of the transmission of the effect of herding behavior on inflation from the housing price channel, while the Sobel test did not confirm the transmission of the effect of overconfidence from the housing price channel on inflation

Extended AbstractAbstractIn such circumstances where Organizations must be able manage all their resources, the ability of developed organizations relies on the specialized human resources as strategic assets. One of the methods for the fundamental changes and based on organized insights in the field of human resources is to implement a succession planning model in organizations. This research is applied in terms of purpose and qualitative research in terms of execution. The population of this study, including experts with a scientific background and related field in ABFA Semnan Company and the research sample was theoretical (purposive) sampling method. Interviews used in order to collect qualitative data and to analyze the data obtained from the interviews, the content analysis was used. Analysis results showed that identifying the organization's needs and competencies required, identifying skills through the skill repository, training and utilization, evaluation and review as the main categories in designing a succession planning model in ABFA Semnan Company with an emphasis on talent management.IntroductionSuccession planning guarantees the survival and future success of an organization through identifying and nurturing persons enjoying leadership talent. Focusing on their influence, vision, and innovation competent leaders can identify the long term targets and create inspirational outlook for the organization. The procedure of succession planning in organizations is one of the macro strategies of human resources management. The lack of qualified manpower in markets despite of organizations’ growing need for human resources to deal with environment changes and treats is serious. Currently, there is an urgent necessity and a crying need of programming for succession planning. Succession planning is regarded as an effective strategy for qualified and competence human resources provision. Such strategy supplies the required infrastructure for crucial posts in the organizations. Identifying and nurturing the talented persons will result in effective and efficient leadership continuity. The preliminary survey reveals that implementing local succession planning in Abfa Company in Semnan province requires an accurate programming to identify and recruit the talented features and trying to develop and preserve them. Taking all above-mentioned explanation into account, implementing the succession planning program will provide the Abfa Company of Semnan province with opportunities and advantages that are going to be discussed in the present study. This study aims to provide the Abfa Company with a model of succession planning organization in order to guide the decision makers of the Company to orient the managers so as never suffers from the lack of professional experts and managers. Case studyThe location of the study is Abfa Company in Semnan province.Materials and MethodsThe present study has been planned and conducted to identify the succession planning through focusing on talent management. Regarding the exploratory feature of this research, the variables and the relations between them have been extracted through a qualify research. Accordingly, using the qualified research of identification features of the succession planning model which concentrated on talent management, the professional and experts have been selected through interview. The interviews have been studied under the method of thematic analysis. The coding method has been used in the research and the presented contents by the participants have been accurately written, recorded and reported, and the related matters have been identified. Then, based on the research enquiry and the achieved results from the data qualitative analysis out of interviews with the managers and senior experts of Abfa Company in Semnan, the results and findings have been analyzed and interpreted. Discussion and ResultsHaving interviewed with the experts and managers of the afore-mentioned organization, the coding of the interviews were one. In the first phase, 884 primary codes were detected out of different data. In the second phase, 145 codes were detected through omitting the similar ones. The next step was to extract the basic themes for which the researcher put those codes and themes that hold the most identical meanings together and created new meaning and words and achieved 92 basic themes.In the next phase, the extracted basic themes were categorized into 5 organizer categories that will be clarified below.Determining the strategic occupations criteria: 1) the effects of occupation on salary 2) the relation between the occupation with a responsibility and significant process 3) the effect of occupation in profitability 4) occupations with no one being in charge of 5) the possibility of replacing (feasibility and difficulty) 6) the viewpoints of the related manager or head on occupation 7) the impacts of not fulfilling the responsibilities of the occupation 8) setting points for the factors of determining strategic occupations 9) grouping the occupations under the three subdivisions of strategic, significant and ordinary 10) the ability to design an outlook 11) leadership 12) strategic thinking 13) decision making ability 14) programming and organizing 15) change management 16) micro and macro management 17) team leadership 18) information management 19) innovation and creativity 20) intermediation 21) encouraging and cheering up 22) nurturing the personnel 23) innovation 24) diversity management 25) effective and efficient communications 26) learning 27) problem solving 28) business intuition 29) Team building 30) initiative 31) the effectiveness of interpersonal relationship 32) market focusing 33) team working and value creation 34) change management 35) responsibility technical skills 36) character integrity 37) high intelligence 38) management and commanding skills 39) designing the data bank of personnel 40) the role of technology in identifying talent sources 41) identification procedure 42) planning for identifying talented ones 43) identifying and preparing the successors 44) determining the management talents of personnel 45) identifying the best alternatives for management and leadership in the organization 46) identifying external probable alternatives 47) increasing the talents sources composing extensible personnel 48) matching and alignment between the existing talented personnel in the organization and the required talented ones in the future 49) providing opportunities for personnel enjoying high potentialities 50) the continuity of leadership development and thinking talent 51) internal talents developing 52) strategic talent developing 53) abilities identification 54) talents sources formation 55) benefiting from qualified personnel 56) talents identification 57) personnel training 58) individual and organizational maturity 59) personal empowerment 60) professional development of personnel 61) the growth of personnel along with the official path of the organization 62) improving individual performance 63) self actualization 64) role-playing of the individuals in the organization 65) individual improvement 66) self-training 67) the opportunity for creativity 68) improving manpower 69) qualified management training 70) individual and occupational development 71) qualification of education 72) talents assessment 73) ability assessment 74) skill assessment 75) individual assessment 76) job assessment 77) performance assessment 78) the ability to summarize 79) team building 80) strategic and analytical thinking 81) feasibility in appointing individuals 82) acceptable number of candidates in talents source for management 83) the positive performance of selected individuals 84) characteristics 85) structured interviews 86) non-artificial interviews 87) self- assessment questionnaires 88) characteristics tests 89) psychometric tests 90) ability and talent tests 91) skill assessments tests 92) knowledge difficulty tests ConclusionThe main task of the present research was to identify the succession planning through focusing on talent management which happened in defining the terms and delivering reports, so as to form the relations afterwards. Identifying the model has started after the identification of the organizations’ requirements. According to the results and emphasis of the key informative ones, the criteria of identifying the necessary competencies were regarded as the second factor. Identifying the talented individuals through talent source was also introduced as one of the main factors. Taking the extracted factors into account, another main factor is education and utilization. Finally, another main factor was announced titled assessment and review for assessing the level of success and efficiency of the succession planning.

Background: Gallbladder agenesis is a biliary tract related congenital malformation with an incidence of 10–65 per 100,000 and associated with other congenital abnormalities. GA is usually asymptomatic, but sometimes patients become symptomatic. The most usual symptoms are jaundice, abdominal pain in the right upper quadrant, nausea and vomiting. We reported a case of GA and choledochogastric fistula in a patient with history of cholangitis. Case Presentation: A 70-year-old man presented to Emergency Department of Modarres Hospital with jaundice, fever, right upper quadrant abdominal pain, nausea and vomiting. Clinical examination and lab test demonstrated cholangitis. He underwent ultrasonography, abdominopelvic CT scan and ERCP. ERCP revealed a CBD fistula. Due to recurrent symptoms, he underwent operation and hepaticojejunostomy was done. Conclusion: In our knowledge, the case of GA and choledochogastric fistula is rare. Furthermore, this type of abnormalities rarely presented with cholangitis, so probable anatomical malformation of the biliary tract should always be considered as a differential diagnosis in patients with biliary disease signs and symptoms

Abstract One of the primary goals for the researchers is to create a high-quality sensor with a simple structure because of the urgent requirement to identify biomolecules at low concentrations to diagnose diseases and detect hazardous chemicals for health early on. Recently graphene has attracted much interest in the field of improved biosensors. Meanwhile, graphene with new materials such as CaF2 has been widely used to improve the applications of graphene-based sensors. Using the fantastic features of the graphene/CaF2 multilayer, this article proposes an improvement sensor in the sensitivity (S), the figure of merit (FOM), and the quality factor (Q). The proposed sensor is based on the five-layers graphene/dielectric grating integrated with a Fabry–Perot cavity. By tuning graphene chemical potential (µc), due to the semi-metal features of graphene, the surface plasmon resonance (SPR) waves excited at the graphene/dielectric boundaries. Due to the vertical polarization of the source to the gratings and the symmetry of the electric field, both corners of the grating act as electric dipoles, and this causes the propagation of plasmonic waves on the graphene surface to propagate towards each other. Finally, it causes Fabry–Perot (FP) interference on the surface of graphene in the proposed structure's active medium (the area where the sample is located). In this article, using the inherent nature of FP interference and its S to the environment's refractive index (RI), by changing a minimal amount in the RI of the sample, the resonance wavelength (interferometer order) shifts sharply. The proposed design can detect and sense some cancers, such as Adrenal Gland Cancer, Blood Cancer, Breast Cancer I, Breast Cancer II, Cervical Cancer, and skin cancer precisely. By optimizing the structure, we can achieve an S as high as 9000 nm/RIU and a FOM of about 52.14 for the first resonance order (M1). Likewise, the remarkable S of 38,000 nm/RIU and the FOM of 81 have been obtained for the second mode (M2). In addition, the proposed label-free SPR sensor can detect changes in the concentration of various materials, including gases and biomolecules, hemoglobin, breast cancer, diabetes, leukemia, and most alloys, with an accuracy of 0.001. The proposed sensor can sense urine concentration with a maximum S of 8500 nm/RIU and cancers with high S in the 6000 nm/RIU range to 7000 nm/RIU. Also, four viruses, such as M13 bacteriophage, HIV type one, Herpes simplex type 1, and influenza, have been investigated, showing Maximum S (for second resonance mode of λR(M2) of 8000 nm/RIU (λR(M2) = 11.2 µm), 12,000 nm/RIU (λR(M2) = 10.73 µm), 38,000 nm/RIU (λR(M2) = 11.78 µm), and 12,000 nm/RIU (λR(M2) = 10.6 µm), respectively, and the obtained S for first resonance mode (λR(M1)) for mentioned viruses are 4740 nm/RIU (λR(M1) = 8.7 µm), 8010 nm/RIU (λR(M1) = 8.44 µm), 8100 nm/RIU (λR(M1) = 10.15 µm), and 9000 (λR(M1) = 8.36 µm), respectively.

Abstract Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular membrane structures. Cholesterol is involved in numerous cellular processes, including regulating virus entry into the host cell. Multiple viruses have been shown to rely on cholesterol for virus entry and/or morphogenesis. Research indicates that reprogramming of the host’s lipid metabolism is associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the progression to severe liver disease for viruses that cause chronic hepatitis. Moreover, knowing the precise mode of viral interaction with target cells sheds light on viral pathogenesis and aids in the development of vaccines and therapeutic targets. As a result, the area of cholesterol-lowering therapy is quickly evolving and has many novel antiviral targets and medications. It has been shown that microRNAs (miRNAs) either directly or indirectly target the viral genome, preventing viral replication. Moreover, miRNAs have recently been shown to be strong post-transcriptional regulators of the genes involved in lipid metabolism, particularly those involved in cholesterol homeostasis. As important regulators of lipid homeostasis in several viral infections, miRNAs have recently come to light. In addition, multiple studies demonstrated that during viral infection, miRNAs modulate several enzymes in the mevalonate/cholesterol pathway. As cholesterol metabolism is essential to the life cycle of viral hepatitis and other viruses, a sophisticated understanding of miRNA regulation may contribute to the development of a novel anti-HCV treatment. The mechanisms underlying the effectiveness of miRNAs as cholesterol regulators against viral hepatitis are explored in this review. Video Abstract Graphical Abstract

Abstract Background Spermatozoa retrieved from the testis and epididymis are deprived of the beneficial effects of seminal fluid. Thus applying an artificial medium with normal seminal fluid characteristics, known as artificial seminal fluid (ASF), may provide an appropriate condition for improving some sperm parameters in azoospermia. The objective was to investigate the impact of in vitro exposure of testicular and epididymal spermatozoa to ASF on sperm quality. The study was conducted on testicular (n = 20) and epididymal (n = 20) sperm specimens obtained from azoospermic men. Each sample was divided into two equal parts: Part I) for processing and incubation with Ham’s F10 medium; Part II) for processing and incubation with ASF. Results After 2 h incubation, testicular sperm motility was significantly higher in ASF than in Ham’s F10 medium. In comparison to 0 h, mitochondrial membrane potential levels of testicular spermatozoa were significantly higher after 2 h and 24 h in ASF and after 24 h in Ham’s F10 medium. Furthermore, the data indicated significantly lower rates of epididymal spermatozoa with high MMP in both media after 24 h. There were no significant differences in the DNA fragmentation index of testicular and epididymal spermatozoa between ASF and Ham’s F10 medium at different time points. Conclusion The results demonstrated that in vitro incubation of testicular spermatozoa improved their motility more effectively than Ham’s F10 medium in the short term (2 h), but had no effect on epididymal spermatozoa. Since the physiology of testicular spermatozoa is different from that of ejaculated spermatozoa, it seems that a special environment should be designed and used for each of them.

Understanding how environmental factors shape patterns of genetic and phenotypic variations in a species is necessary for conservation and plant breeding. However, these factors have not yet been completely understood in tuberous orchid species used to make 'Salep', an important ingredient in traditional medicine and beverages in middle eastern countries and India. In many areas, increasing demand has pushed species to the brink of extinction. In this study, 198 genotypes from 18 populations of the endangered species Orchis mascula L. spanning a large-scale climatic gradient in northern Iran were used to investigate patterns of genetic diversity and plant functional traits. Populations were sampled from three land cover types (woodland, shrubland, and pastureland/grassland). Plant height, stem length, number of flowers, bulb fresh and dry weight, glucomannan, and starch concentrations showed high variation among populations and were significantly related to land cover type. In general, genetic diversity was high, particularly in those from eastern Hyrcanian; additionally, populations showed a high level of genetic differentiation (G'st = 0.35) with low gene flow (Nm = 0.46). The majority of genetic differentiation occurred within populations (49%) and land cover types (20%). The population structural analysis using the AFLP marker data in K = 4 showed a high geographical affinity for 198 O. mascula genotypes, with some genotypes having mixed ancestry. Temperature and precipitation were found to shape genetic and phenotypic variation profoundly. Significant isolation by the environment was observed, confirming the strong effect of environmental variables on phenotypic and genetic variation. Marker-trait association studies based on MLM1 and MLM2 models revealed significant associations of P-TGG + M-CTT-33 and E-AGG + M-CGT-22 markers with plant height and glucomannan content. Overall, a combination of large-scale climatic variables and land cover types significantly shaped genetic diversity and functional trait variation in O. mascula populations.

Dielectric quality tests require a high AC voltage with a frequency range of 0.0001 Hz to 1000 Hz. However, providing a high AC voltage with such a frequency variety is challenging. Providing a high DC voltage and then applying such a voltage to an inverter to adjust the frequency can be an acceptable solution for such a challenge. Notably, a high DC voltage is required for DC tests. This study proposes an improved form of the cascaded boost converter, whose merits are as follows: (i) the high voltage gain providing low duty cycles is possible; (ii) the input current is continuous, which decreases the current ripple of the input filter capacitor; (iii) the current stress of the semiconductors is less than the input current, and most of them have a large difference with it; (iv) the voltage stress of the semiconductors is less than the output voltage with a large difference; (v) only one switch with a simple drive circuit is used; (vi) the common ground of the load and input source decreases the EMI noise; (vii) besides the high voltage gain, the voltage density of the converter based on the number of inductors, capacitors, switches, diodes, and whole components is greater than that of the recently proposed converters; (viii) only two stacked connections of the proposed topology can provide a 2.6 kV voltage for a higher DC voltage test of dielectrics. The functional details of the converter are extracted in ideal and continuous conduction (CCM) modes. Moreover, the converter’s voltage gain and density are compared with the recently proposed converters to show the superiority of the proposed converter. Finally, the experimental results are presented to validate the theoretical relations in a 140 W output power.

This feasibility study investigates extracting thermal energy from the Bedretto tunnel in the Swiss Alps, which benefits from subsurface heat flux and rock overburden insulation. Using the simulation software COMSOL Multiphysics, we created a numerical model of the tunnel environment to evaluate which medium between rock, air, and water serves as the most effective heat source. Our findings indicate that flowing water is the most effective heat source. Potential applications include distributing the water to nearby villages and storing remaining heat in the subsurface. Estimates indicate that the total extractable thermal energy ranges between 0.8 MWth and 1.5 MWth after reducing the water temperature to 4 °C via a heat pump. The study identifies the most suitable energy sourcing locations based on efficiency and investment costs. Circulating water to individual heat pumps in Bedretto, with the natural elevation difference, enables water transport without a pump. Cost analyses reveal that the investment in piping and heat pumps can be amortized within the equipment’s lifespan with appropriate economic models. With the same initial investments, district heating systems are viable in villages with over 30 connections. The payback periods are 10 years for 60 connections, 4.5 years for 90 connections, and immediate for 200 connections.