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201. Observation of a Large-scale Anisotropy in the Arrival Directions of Cosmic Rays above $8 \times 10^{18}$ eV

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Cobos, A., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Jurysek, J., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemmerich, N., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Presti, D. Lo, Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Michal, S., Micheletti, M. I., Middendorf, L., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Riehn, F., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Šupík, J., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, R. A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Cosmic rays are atomic nuclei arriving from outer space that reach the highest energies observed in nature. Clues to their origin come from studying the distribution of their arrival directions. Using $3 \times 10^4$ cosmic rays above $8 \times 10^{18}$ electron volts, recorded with the Pierre Auger Observatory from a total exposure of 76,800 square kilometers steradian year, we report an anisotropy in the arrival directions. The anisotropy, detected at more than the 5.2$\sigma$ level of significance, can be described by a dipole with an amplitude of $6.5_{-0.9}^{+1.3}$% towards right ascension $\alpha_{d} = 100 \pm 10$ degrees and declination $\delta_{d} = -24_{-13}^{+12}$ degrees. That direction indicates an extragalactic origin for these ultra-high energy particles., Comment: 19 pages (with supplementary material), 8 figures
Published: 2017
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202. Spectral Calibration of the Fluorescence Telescopes of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Biermann, P. L., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Cobos, A., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Halliday, R., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Johnsen, J. A., Josebachuili, M., Jurysek, J., Kääpä, A., Kambeitz, O., Kampert, K. H., Keilhauer, B., Kemmerich, N., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, Lago, B. L., LaHurd, D., Lang, R. G., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Presti, D. Lo, Lopes, L., López, R., Casado, A. López, Lorek, R., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Michal, S., Micheletti, M. I., Middendorf, L., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlin, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Ridky, J., Riehn, F., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schröder, S., Schulz, A., Schumacher, J., Sciutto, S. J., Segreto, A., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Stolpovskiy, M., Strafella, F., Streich, A., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Šupík, J., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, R. A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: We present a novel method to measure precisely the relative spectral response of the fluorescence telescopes of the Pierre Auger Observatory. We used a portable light source based on a xenon flasher and a monochromator to measure the relative spectral efficiencies of eight telescopes in steps of 5 nm from 280 nm to 440 nm. Each point in a scan had approximately 2 nm FWHM out of the monochromator. Different sets of telescopes in the observatory have different optical components, and the eight telescopes measured represent two each of the four combinations of components represented in the observatory. We made an end-to-end measurement of the response from different combinations of optical components, and the monochromator setup allowed for more precise and complete measurements than our previous multi-wavelength calibrations. We find an overall uncertainty in the calibration of the spectral response of most of the telescopes of 1.5% for all wavelengths; the six oldest telescopes have larger overall uncertainties of about 2.2%. We also report changes in physics measureables due to the change in calibration, which are generally small., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2017
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203. The Pierre Auger Observatory: Contributions to the 35th International Cosmic Ray Conference (ICRC 2017)

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Luz, R. J. Barreira, Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Cobos, A., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Freire, M. M., Fujii, T., Fuster, A., Gaïor, R., García, B., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Halliday, R., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Johnsen, J. A., Josebachuili, M., Jurysek, J., Kääpä, A., Kambeitz, O., Kampert, K. H., Keilhauer, B., Kemmerich, N., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, Lago, B. L., LaHurd, D., Lang, R. G., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Presti, D. Lo, Lopes, L., López, R., Casado, A. López, Lorek, R., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Michal, S., Micheletti, M. I., Middendorf, L., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Morlino, G., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlin, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Poh, J., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Ridky, J., Riehn, F., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schröder, S., Schulz, A., Schumacher, J., Sciutto, S. J., Segreto, A., Shellard, R. C., Sigl, G., Silli, G., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Soriano, J. F., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Stolpovskiy, M., Strafella, F., Streich, A., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Šupík, J., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Vázquez, R. A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiedeński, M., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Contributions of the Pierre Auger Collaboration to the 35th International Cosmic Ray Conference (ICRC 2017), 12-20 July 2017, Bexco, Busan, Korea., Comment: compendium of 26 proceedings for the ICRC 2017
Published: 2017

204. Muon Counting using Silicon Photomultipliers in the AMIGA detector of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollant, R., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: AMIGA (Auger Muons and Infill for the Ground Array) is an upgrade of the Pierre Auger Observatory designed to extend its energy range of detection and to directly measure the muon content of the cosmic ray primary particle showers. The array will be formed by an infill of surface water-Cherenkov detectors associated with buried scintillation counters employed for muon counting. Each counter is composed of three scintillation modules, with a 10 m$^2$ detection area per module. In this paper, a new generation of detectors, replacing the current multi-pixel photomultiplier tube (PMT) with silicon photo sensors (aka. SiPMs), is proposed. The selection of the new device and its front-end electronics is explained. A method to calibrate the counting system that ensures the performance of the detector is detailed. This method has the advantage of being able to be carried out in a remote place such as the one where the detectors are deployed. High efficiency results, i.e. 98 % efficiency for the highest tested overvoltage, combined with a low probability of accidental counting ($\sim$2 %), show a promising performance for this new system., Comment: 24 pages, 12 figures
Published: 2017
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205. Calibration of the Logarithmic-Periodic Dipole Antenna (LPDA) Radio Stations at the Pierre Auger Observatory using an Octocopter

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Cobos, A., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemmerich, N., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Presti, D. Lo, Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: An in-situ calibration of a logarithmic periodic dipole antenna with a frequency coverage of 30 MHz to 80 MHz is performed. Such antennas are part of a radio station system used for detection of cosmic ray induced air showers at the Engineering Radio Array of the Pierre Auger Observatory, the so-called Auger Engineering Radio Array (AERA). The directional and frequency characteristics of the broadband antenna are investigated using a remotely piloted aircraft (RPA) carrying a small transmitting antenna. The antenna sensitivity is described by the vector effective length relating the measured voltage with the electric-field components perpendicular to the incoming signal direction. The horizontal and meridional components are determined with an overall uncertainty of 7.4^{+0.9}_{-0.3} % and 10.3^{+2.8}_{-1.7} % respectively. The measurement is used to correct a simulated response of the frequency and directional response of the antenna. In addition, the influence of the ground conductivity and permittivity on the antenna response is simulated. Both have a negligible influence given the ground conditions measured at the detector site. The overall uncertainties of the vector effective length components result in an uncertainty of 8.8^{+2.1}_{-1.3} % in the square root of the energy fluence for incoming signal directions with zenith angles smaller than 60{\deg}., Comment: Published version. Updated online abstract only. Manuscript is unchanged with respect to v2. 39 pages, 15 figures, 2 tables
Published: 2017
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206. Elicitation of societal preferences for chronic lymphocytic leukemia's treatments: a discrete choice experiment.

Author: Borsoi, Ludovica, Costa, Francesco, Milano, Carlo, Segantin, Gaia, Ghia, Paolo, and Armeni, Patrizio
Abstract: The overall value of treatments for chronic lymphocytic leukemia (CLL) depends on several factors, including preferences of the general population, who contributes to the financing of health systems. This study investigated societal preferences for attributes of CLL treatments in Italy. An online large-scale survey was designed using a discrete choice experiment (DCE) methodology and delivered to the Italian adult general population. Ten treatment attributes were identified, covering efficacy, safety, operational aspects and (hypothetical) out-of-pocket cost. DCE data were analyzed using a mixed logit regression model, estimating the willingness-to-pay for attribute levels' change. The general population significantly preferred more effective treatments, with shorter duration, administered orally rather than orally + intravenously. Changes in therapy duration, frequency of checkups and organ damage risk had the greatest impact on preferences. The integration of societal preferences in the value judgments of CLL therapies may help health authorities in establishing priority setting and taking pricing-reimbursement decisions. [ABSTRACT FROM AUTHOR]
Published: 2024
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207. Outcomes and prognostic factors in 3306 patients with relapsed/refractory chronic lymphocytic leukemia treated with ibrutinib outside of clinical trials: A nationwide study.

Author: Rigolin, Gian Matteo, Olimpieri, Pier Paolo, Summa, Valentina, Celant, Simone, Scarfò, Lydia, Ballardini, Maria Pia, Urso, Antonio, Gambara, Silvia, Cavazzini, Francesco, Ghia, Paolo, Cuneo, Antonio, and Russo, Pierluigi
Published: 2024
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208. Stereotactic radiosurgery for prostate cancer spine metastases: local control and fracture risk using a simultaneous integrated boost approach.

Author: Beckham, Thomas H., Rooney, Michael K., Cifter, Gizem, Bernard, Vincent, McAleer, Mary Frances, De, Brian S., Tom, Martin C., Perni, Subha, Chenyang Wang, Swanson, Todd, Tatsui, Claudio E., Alvarez-Breckenridge, Christopher, North, Robert, Rhines, Laurence D., Chad Tang, Logothetis, Christopher, Amini, Behrang, Jing Li, Yeboa, Debra N., and Ghia, Amol J.
Published: 2024
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209. Combined fit of spectrum and composition data as measured by the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a combined fit of a simple astrophysical model of UHECR sources to both the energy spectrum and mass composition data measured by the Pierre Auger Observatory. The fit has been performed for energies above $5 \cdot 10^{18}$ eV, i.e.~the region of the all-particle spectrum above the so-called "ankle" feature. The astrophysical model we adopted consists of identical sources uniformly distributed in a comoving volume, where nuclei are accelerated through a rigidity-dependent mechanism. The fit results suggest sources characterized by relatively low maximum injection energies, hard spectra and heavy chemical composition. We also show that uncertainties about physical quantities relevant to UHECR propagation and shower development have a non-negligible impact on the fit results., Comment: Corrected typos in values of SD vertical spectrum energy bias (B.5); Added expression for SD inclined spectrum energy resolution (B.6), erroneously claimed to have been published before
Published: 2016
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210. A targeted search for point sources of EeV photons with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined $p$-values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. These limits significantly constrain predictions of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region., Comment: Published version
Published: 2016
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211. Search for photons with energies above 10$^{18}$ eV using the hybrid detector of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract: A search for ultra-high energy photons with energies above 1 EeV is performed using nine years of data collected by the Pierre Auger Observatory in hybrid operation mode. An unprecedented separation power between photon and hadron primaries is achieved by combining measurements of the longitudinal air-shower development with the particle content at ground measured by the fluorescence and surface detectors, respectively. Only three photon candidates at energies 1 - 2 EeV are found, which is compatible with the expected hadron-induced background. Upper limits on the integral flux of ultra-high energy photons of 0.038, 0.010, 0.009, 0.008 and 0.007 km$^{-2}$ sr$^{-1}$ yr$^{-1}$ are derived at 95% C.L. for energy thresholds of 1, 2, 3, 5 and 10 EeV. These limits bound the fractions of photons in the all-particle integral flux below 0.14%, 0.17%, 0.42%, 0.86% and 2.9%. For the first time the photon fraction at EeV energies is constrained at the sub-percent level. The improved limits are below the flux of diffuse photons predicted by some astrophysical scenarios for cosmogenic photon production. The new results rule-out the early top-down models $-$ in which ultra-high energy cosmic rays are produced by, e.g., the decay of super-massive particles $-$ and challenge the most recent super-heavy dark matter models., Comment: Corrected version after erratum published in JCAP
Published: 2016
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212. The Editorial Position on ‘Recent Advances in Multifunctional Antimicrobial Peptides as Preclinical Therapeutic Studies and Clinical Future Applications’

Author: Francesco Scavello, Mohamed Amiche, and Jean-Eric Ghia
Subjects: n/a, Pharmacy and materia medica, RS1-441
Abstract: Antibiotic resistance has recently been recognized as an alarming issue and one of the leading causes of death worldwide [...]
Published: 2023
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213. Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia

Author: Matthew Kaufman, Xiao-Jie Yan, Wentian Li, Emanuela M. Ghia, Anton W. Langerak, Laura Z. Rassenti, Chrysoula Belessi, Neil E. Kay, Frederic Davi, John C. Byrd, Sarka Pospisilova, Jennifer R. Brown, Mark Catherwood, Zadie Davis, David Oscier, Marco Montillo, Livio Trentin, Richard Rosenquist, Paolo Ghia, Jacqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Kostas Stamatopoulos, Thomas J. Kipps, Donna Neuberg, and Nicholas Chiorazzi
Subjects: chronic lymphocytic leukemia, CLL, somatic mutations, immunoglobulin variable domain, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells, B-cell receptor (BCR) signaling is likely at the heart of the worse outcomes of CLL cases without/few IGHV mutations. A corollary of this conclusion is that M-CLL follow less aggressive clinical courses because somatic IGHV mutations have altered BCR structures and no longer bind stimulatory (auto)antigens and so cannot deliver trophic signals to leukemic B cells. However, the latter assumption has not been confirmed in a large patient cohort. We tried to address the latter by measuring the relative numbers of replacement (R) mutations that lead to non-conservative amino acid changes (Rnc) to the combined numbers of conservative (Rc) and silent (S) amino acid R mutations that likely do not or cannot change amino acids, “(S+Rc) to Rnc IGHV mutation ratio”. When comparing time-to-first-treatment (TTFT) of patients with (S+Rc)/Rnc ≤ 1 and >1, TTFTs were similar, even after matching groups for equal numbers of samples and identical numbers of mutations per sample. Thus, BCR structural change might not be the main reason for better outcomes for M-CLL. Since the total number of IGHV mutations associated better with longer TTFT, better clinical courses appear due to the biologic state of a B cell having undergone many stimulatory events leading to IGHV mutations. Analyses of larger patient cohorts will be needed to definitively answer this question.
Published: 2022
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214. Management of Spine SBRT Adverse Effects

Author: Bernard, Vincent, Ghia, Amol J., Lee, Nancy Y., Series Editor, Lu, Jiade J., Series Editor, Halasz, Lia M., editor, Lo, Simon S., editor, Chang, Eric L., editor, and Sahgal, Arjun, editor
Published: 2021
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215. Genetic and phenotypic attributes of splenic marginal zone lymphoma

Author: Bonfiglio, Ferdinando, Bruscaggin, Alessio, Guidetti, Francesca, Terzi di Bergamo, Lodovico, Faderl, Martin, Spina, Valeria, Condoluci, Adalgisa, Bonomini, Luisella, Forestieri, Gabriela, Koch, Ricardo, Piffaretti, Deborah, Pini, Katia, Pirosa, Maria Cristina, Cittone, Micol Giulia, Arribas, Alberto, Lucioni, Marco, Ghilardi, Guido, Wu, Wei, Arcaini, Luca, Baptista, Maria Joao, Bastidas, Gabriela, Bea, Silvia, Boldorini, Renzo, Broccoli, Alessandro, Buehler, Marco Matteo, Canzonieri, Vincenzo, Cascione, Luciano, Ceriani, Luca, Cogliatti, Sergio, Corradini, Paolo, Derenzini, Enrico, Devizzi, Liliana, Dietrich, Sascha, Elia, Angela Rita, Facchetti, Fabio, Gaidano, Gianluca, Garcia, Juan Fernando, Gerber, Bernhard, Ghia, Paolo, Gomes da Silva, Maria, Gritti, Giuseppe, Guidetti, Anna, Hitz, Felicitas, Inghirami, Giorgio, Ladetto, Marco, Lopez-Guillermo, Armando, Lucchini, Elisa, Maiorana, Antonino, Marasca, Roberto, Matutes, Estella, Meignin, Veronique, Merli, Michele, Moccia, Alden, Mollejo, Manuela, Montalban, Carlos, Novak, Urban, Oscier, David Graham, Passamonti, Francesco, Piazza, Francesco, Pizzolitto, Stefano, Rambaldi, Alessandro, Sabattini, Elena, Salles, Gilles, Santambrogio, Elisa, Scarfò, Lydia, Stathis, Anastasios, Stüssi, Georg, Geyer, Julia T., Tapia, Gustavo, Tarella, Corrado, Thieblemont, Catherine, Tousseyn, Thomas, Tucci, Alessandra, Vanini, Giorgio, Visco, Carlo, Vitolo, Umberto, Walewska, Renata, Zaja, Francesco, Zenz, Thorsten, Zinzani, Pier Luigi, Khiabanian, Hossein, Calcinotto, Arianna, Bertoni, Francesco, Bhagat, Govind, Campo, Elias, De Leval, Laurence, Dirnhofer, Stefan, Pileri, Stefano A., Piris, Miguel A., Traverse-Glehen, Alexandra, Tzankov, Alexander, Paulli, Marco, Ponzoni, Maurilio, Mazzucchelli, Luca, Cavalli, Franco, Zucca, Emanuele, and Rossi, Davide
Published: 2022
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216. On the use of metal-organic framework-based adsorbent from recycled PET bottles for Eriochrome Black T removal

Author: Bool, Reaner Jacqueline A., Luwalhati, Ghia C., Tan, Nicole Elizabeth Y., Aquino, Anita P., and Maalihan, Reymark D.
Published: 2022
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217. Thecal Sac Contouring as a Surrogate for the Cauda Equina and Intracanal Spinal Nerve Roots for Spine Stereotactic Body Radiation Therapy (SBRT): Contour Variability and Recommendations for Safe Practice

Author: Dunne, Emma M., Lo, Simon S., Liu, Mitchell C., Bergman, Alanah, Kosztyla, Robert, Chang, Eric L., Chang, Ung-Kyu, Chao, Samuel T., Dea, Nicolas, Faruqi, Salman, Ghia, Amol J., Redmond, Kristin J., Soltys, Scott G., and Sahgal, Arjun
Published: 2022
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218. Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model

Author: Filippo Severin, Andrea Urbani, Tatiana Varanita, Magdalena Bachmann, Michele Azzolini, Veronica Martini, Marco Pizzi, Angelo Paolo Dei Tos, Federica Frezzato, Andrea Mattarei, Paolo Ghia, Maria Teresa Sabrina Bertilaccio, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Gianpietro Carlo Semenzato, Luigi Leanza, Livio Trentin, and Ildiko Szabò
Subjects: Ion channels, Chronic lymphocytic leukemia, Drug resistance, Mitochondria, Apoptosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells, compared to healthy lymphocytes. In vitro, inhibition of mitoKv1.3 by PAPTP was shown to kill ex vivo primary human CLL cells, while targeting IKCa with TRAM-34 decreased CLL cell proliferation. Methods Here we evaluated the effect of the above drugs in CLL cells from ibrutinib-resistant patients and in combination with Venetoclax, two drugs used in the clinical practice. The effects of the drugs were tested also in the Eμ-TCL1 genetic CLL murine model, characterized by a lympho-proliferative disease reminiscent of aggressive human CLL. Eμ-TCL1 mice showing overt disease state were treated with intraperitoneal injections of non-toxic 5 nmol/g PAPTP or 10 nmol/g TRAM-34 once a day and the number and percentage of pathological B cells (CD19+CD5+) in different, pathologically relevant body districts were determined. Results We show that Kv1.3 expression correlates with sensitivity of the human and mouse neoplastic cells to PAPTP. Primary CLL cells from ibrutinib-resistant patients could be killed with PAPTP and this drug enhanced the effect of Venetoclax, by acting on mitoKv1.3 of the inner mitochondrial membrane and triggering rapid mitochondrial changes and cytochrome c release. In vivo, after 2 week- therapy of Eμ-TCL1 mice harboring distinct CLL clones, leukemia burden was reduced by more than 85%: the number and percentage of CLL B cells fall in the spleen and peritoneal cavity and in the peripheral blood, without signs of toxicity. Notably, CLL infiltration into liver and spleen and splenomegaly were also drastically reduced upon PAPTP treatment. In contrast, TRAM-34 did not exert any beneficial effect when administered in vivo to Eμ-TCL1 mice at non-toxic concentration. Conclusion Altogether, by comparing vehicle versus compound effect in different Eμ-TCL1 animals bearing unique clones similarly to CLL patients, we conclude that PAPTP significantly reduced leukemia burden in CLL-relevant districts, even in animals with advanced stage of the disease. Our results thus identify PAPTP as a very promising drug for CLL treatment, even for the chemoresistant forms of the disease.
Published: 2022
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219. T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations

Author: Elisavet Vlachonikola, Nikolaos Pechlivanis, Georgios Karakatsoulis, Electra Sofou, Glykeria Gkoliou, Sabine Jeromin, Niki Stavroyianni, Pamela Ranghetti, Lydia Scarfo, Cecilia Österholm, Larry Mansouri, Sofia Notopoulou, Alexandra Siorenta, Achilles Anagnostopoulos, Paolo Ghia, Claudia Haferlach, Richard Rosenquist, Fotis Psomopoulos, Anastasia Kouvatsi, Panagiotis Baliakas, Kostas Stamatopoulos, and Anastasia Chatzidimitriou
Subjects: T cell receptor (TR) gene repertoire, chronic lymphocytic leukemia (CLL), recurrent genomic aberrations, neoepitopes, T cell based immunotherapies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: BackgroundMicroenvironmental interactions of the malignant clone with T cells are critical throughout the natural history of chronic lymphocytic leukemia (CLL). Indeed, clonal expansions of T cells and shared clonotypes exist between different CLL patients, strongly implying clonal selection by antigens. Moreover, immunogenic neoepitopes have been isolated from the clonotypic B cell receptor immunoglobulin sequences, offering a rationale for immunotherapeutic approaches. Here, we interrogated the T cell receptor (TR) gene repertoire of CLL patients with different genomic aberration profiles aiming to identify unique signatures that would point towards an additional source of immunogenic neoepitopes for T cells.Experimental designTR gene repertoire profiling using next generation sequencing in groups of patients with CLL carrying one of the following copy-number aberrations (CNAs): del(11q), del(17p), del(13q), trisomy 12, or gene mutations in TP53 or NOTCH1.ResultsOligoclonal expansions were found in all patients with distinct recurrent genomic aberrations; these were more pronounced in cases bearing CNAs, particularly trisomy 12, rather than gene mutations. Shared clonotypes were found both within and across groups, which appeared to be CLL-biased based on extensive comparisons against TR databases from various entities. Moreover, in silico analysis identified TR clonotypes with high binding affinity to neoepitopes predicted to arise from TP53 and NOTCH1 mutations.ConclusionsDistinct TR repertoire profiles were identified in groups of patients with CLL bearing different genomic aberrations, alluding to distinct selection processes. Abnormal protein expression and gene dosage effects associated with recurrent genomic aberrations likely represent a relevant source of CLL-specific selecting antigens.
Published: 2023
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220. COVID-19 Vaccination Response and Its Practical Application in Patients With Chronic Lymphocytic Leukemia

Author: Mazyar Shadman, Catherine Liu, Katherine Eakle, Hwai J. Hiew, Juliana M.L. Biondo, Paolo Ghia, and Anthony R. Mato
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Patients with chronic lymphocyticleukemia (CLL) typically have innate/adaptive immune system dysregulation, thus the protective effect of coronavirus disease 2019 (COVID-19) vaccination remains uncertain. This prospective review evaluates vaccination response in these patients, including seropositivity rates by CLL treatment status, type of treatment received, and timing of vaccination. Antibody persistence, predictors of poor vaccine response, and severity of COVID-19 infection in vaccinated patients were also analyzed. Practical advice on the clinical management of patients with CLL is provided. Articles reporting COVID-19 vaccination in patients with CLL, published January 1, 2021–May 1, 2022, were included. Patients with CLL displayed the lowest vaccination responses among hematologic malignancies; however, seropositivity increased with each vaccination. One of the most commonly reported independent risk factors for poor vaccine response was active CLL treatment; others included hypogammaglobulinemia and age >65–70 years. Patients who were treatment-naive, off therapy, in remission, or who had a prior COVID-19 infection displayed the greatest responses. Further data are needed on breakthrough infection rates and a heterologous booster approach in patients with hematologic malignancies. Although vaccine response was poor for patients on active therapy regardless of treatment type, CLL management in the context of COVID-19 should aim to avoid delays in antileukemic treatment, especially with the advent of numerous strategies to mitigate risk of severe COVID-19 such as pre-exposure prophylaxis, and highly effective antivirals and monoclonal antibody therapy upon confirmed infection. Patients with CLL should remain vigilant in retaining standard prevention measures such as masks, social distancing, and hand hygiene.
Published: 2023
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221. COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Author: Chatzikonstantinou, Thomas, Kapetanakis, Anargyros, Scarfò, Lydia, Karakatsoulis, Georgios, Allsup, David, Cabrero, Alejandro Alonso, Andres, Martin, Antic, Darko, Baile, Mónica, Baliakas, Panagiotis, Bron, Dominique, Capasso, Antonella, Chatzileontiadou, Sofia, Cordoba, Raul, Correa, Juan-Gonzalo, Cuéllar-García, Carolina, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Demosthenous, Christos, Dimou, Maria, Donaldson, David, Doubek, Michael, Efstathopoulou, Maria, Eichhorst, Barbara, El-Ashwah, Shaimaa, Enrico, Alicia, Espinet, Blanca, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Frederiksen, Henrik, Fürstenau, Moritz, García-Marco, José A., García-Serra, Rocío, Gentile, Massimo, Gimeno, Eva, Glenthøj, Andreas, Gomes da Silva, Maria, Gutwein, Odit, Hakobyan, Yervand K., Herishanu, Yair, Hernández-Rivas, José Ángel, Herold, Tobias, Innocenti, Idanna, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Оlga B., Kalicińska, Elżbieta, Karlsson, Linda Katharina, Kater, Arnon P., Kersting, Sabina, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Levin, Mark-David, Lista, Enrico, Lopez-Garcia, Alberto, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Marquet, Juan, Mattsson, Mattias, Mauro, Francesca R., Milosevic, Ivana, Mirás, Fatima, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Niemann, Carsten U., Rodrigues, Raquel Nunes, Olivieri, Jacopo, Orsucci, Lorella, Papaioannou, Maria, Pavlovsky, Miguel Arturo, Piskunova, Inga, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, Qvist, Kristian, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Saghumyan, Gevorg, Shrestha, Amit, Šimkovič, Martin, Špaček, Martin, Sportoletti, Paolo, Stanca, Oana, Stavroyianni, Niki, Tadmor, Tamar, Te Raa, Doreen, Tonino, Sanne H., Trentin, Livio, Van Der Spek, Ellen, van Gelder, Michel, van Kampen, Roel, Varettoni, Marzia, Visentin, Andrea, Vitale, Candida, Wasik-Szczepanek, Ewa, Wróbel, Tomasz, San Segundo, Lucrecia Yáñez, Yassin, Mohamed, Coscia, Marta, Rambaldi, Alessandro, Montserrat, Emili, Foà, Robin, Cuneo, Antonio, Stamatopoulos, Kostas, and Ghia, Paolo
Published: 2021
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222. Estimating the Public Health and Economic Impact of Introducing the 13-Valent Pneumococcal Conjugate Vaccine or 10-Valent Pneumococcal Conjugate Vaccines into State Immunization Programs in India

Author: Ghia, Canna J., Horn, Emily K., Rambhad, Gautam, Perdrizet, Johnna, Chitale, Ramaa, and Wasserman, Matt D.
Published: 2021
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223. Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Author: Chen, Yun, Choi, Michael Y, Chen, Liguang, Yu, Jian, Zhang, Ling, Ghia, Emanuela M, Sanchez-Lopez, Elsa, Widhopf II, George F, Messer, Karen, Rassenti, Laura Z, Jamieson, Catriona, and Kipps, Thomas J
Subjects: Clinical Research, Hematology, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology
Abstract: Abstract ROR1 is an oncoembryonic receptor tyrosine kinase expressed on chronic lymphocytic leukemia (CLL) B cells, but not on most normal post-partum tissues. It functions as a receptor for Wnt5a, which is present at high levels in the plasma of patients with CLL relative to that of age-matched controls. Wnt5a/ROR1 is known to activate pro-survival signals in CLL cells, but detailed mechanisms are not fully understood. We found that monocyte-derived Nurse-Like Cells (NLC) could induce CLL cells to activate STAT3 (pY705) and that this effect could be blocked by neutralizing antibodies to Wnt5a, which we found expressed at high levels by NLC. We observed that this effect also could be blocked by cirmtuzumab, a humanized mAb that can inhibit ROR1-signaling, indicating this effect of NLC on CLL cells was Wnt5a and ROR1 dependent. We performed a time-course study examining for pSTAT3 in isolated serum-starved CLL cells treated with exogenous Wnt5a. This revealed that Wnt5a induced delayed activation of STAT3, appearing first at 3 hours. As such, we hypothesized that the noted activation of STAT3 in CLL cells was indirect, being caused by a factor(s) made by isolated CLL cells in response to Wnt5a. We examined harvested supernatants of CLL cells cultured with or without Wnt5a using a human cytokine array assay. Multiple proinflammatory factors including IL-6, IL-8, CCL2, CCL3, CCL4, and CXCL1 were detected in the medium of CLL cells cultured for 24 hours with Wnt5a that were either not detected or found at lower levels in the medium of CLL cells cultured without Wnt5a. Moreover, the medium harvested from CLL cells cultured with Wnt5a, but not the medium of CLL cells cultured without, could induce pSTAT3 within 30 minutes in serum-starved CLL cells; this effect could be inhibited by the anti-IL-6-receptor mAb, tocilizumab, but not by cirmtuzumab, even when used at concentrations that could block the capacity of Wnt5a to induce latent activation of STAT3 and production of IL-6. Since the genes encoding these proinflammatory factors are targets of nuclear factor kappa B (NF-κB), we hypothesized that they were induced through Wnt5a/ROR1-dependent activation of NF-κB. Consistent with this notion, we found that BAY 11-7082 or BMS-345541, which can each inhibit activation of NF-κB, also could block Wnt5a-induced CLL-cell activation of STAT3 and production of IL-6. Furthermore, Wnt5a could induce phosphorylation of NF-κB p65 in CLL cells within 30 minutes, and this effect could be blocked by cirmtuzumab. Using real-time PCR array to evaluate for expression of NF-κB target genes, we found Wnt5s could induce up-regulation of NF-κB target genes in CLL cells, and that this effect could be blocked by cirmtuzumab. Moreover, these studies revealed that Wnt5a/ROR1/NF-κB signaling could induce expression of genes encoding the noted proinflammatory factors in CLL cells. To examine the in vivo significance of these findings, we collected plasma and CLL cells from patients treated with cirmtuzumab in a phase I clinical trial (Choi, MY, et al, Cell Stem Cell 22:951, 2018). RNAseq and ELISA respectively were used to examine the transcriptomes of negatively-selected CLL cells and the concentrations of IL-6 in plasma collected before and after treatment. Consistent with our in vitro findings, treatment with cirmtuzumab downregulated CLL-cell expression of NF-κB target genes in vivo by gene set enrichment analysis (n = 3, NES = 2.10, FDR q = 0.01). The levels of IL-6 in plasma also were significantly decreased in patients after therapy (p = 0.02, n = 5, Paired Student t test). Collectively, these studies indicate that Wnt5a/ROR1-dependent signaling induced by NLC may play a major role in the noted activation of NF-κB in CLL, leading to the production of factors, such as IL-6, which are posted to contribute to pathogenesis. Moreover, these data suggest that some of the noted clinical effects of therapy with cirmtuzumab may be due to suppression of Wnt5a-induced, ROR1-dependent activation of NF-κB in patients with CLL. Disclosures Choi: Genentech: Speakers Bureau; Pharmacyclics: Consultancy, Research Funding, Speakers Bureau; Gilead: Speakers Bureau; AbbVie, Inc: Consultancy, Speakers Bureau; Rigel: Consultancy. Kipps:AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Verastem: Membership on an entity's Board of Directors or advisory committees; Verastem: Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Genentech Inc: Consultancy, Research Funding; Gilead: Consultancy, Honoraria, Research Funding; Pharmacyclics: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Consultancy; F. Hoffmann-La Roche Ltd: Consultancy, Research Funding.
Published: 2018

224. Single-agent ibrutinib versus chemoimmunotherapy regimens for treatment-naïve patients with chronic lymphocytic leukemia: A cross-trial comparison of phase 3 studies.

Author: Robak, Tadeusz, Burger, Jan A, Tedeschi, Alessandra, Barr, Paul M, Owen, Carolyn, Bairey, Osnat, Hillmen, Peter, Simpson, David, Grosicki, Sebastian, Devereux, Stephen, McCarthy, Helen, Coutre, Steven E, Quach, Hang, Gaidano, Gianluca, Maslyak, Zvenyslava, Stevens, Don A, Moreno, Carol, Gill, Devinder S, Flinn, Ian W, Gribben, John G, Mokatrin, Ahmad, Cheng, Mei, Styles, Lori, James, Danelle F, Kipps, Thomas J, and Ghia, Paolo
Subjects: Humans, Pyrazoles, Pyrimidines, Antineoplastic Combined Chemotherapy Protocols, Treatment Outcome, Immunotherapy, Survival Analysis, Retrospective Studies, Aged, Middle Aged, Female, Male, Clinical Trials as Topic, Leukemia, Lymphocytic, Chronic, B-Cell, Cancer, Clinical Trials and Supportive Activities, Lymphoma, Rare Diseases, Clinical Research, Hematology, 6.1 Pharmaceuticals, Immunology, Cardiorespiratory Medicine and Haematology
Abstract: Chemoimmunotherapy (CIT) and targeted therapy with single-agent ibrutinib are both recommended first-line treatments for chronic lymphocytic leukemia (CLL), although their outcomes have not been directly compared. Using ibrutinib data from the RESONATE-2 (PCYC-1115/1116) study conducted in patients ≥65 years without del(17p), we performed a cross-trial comparison with CIT data from published phase 3 studies in first-line treatment of CLL. Progression-free survival (PFS), overall survival (OS), and safety data for ibrutinib (median follow-up 35.7 months) were evaluated alongside available CIT data. CIT regimens included: fludarabine + cyclophosphamide + rituximab (CLL8, CLL10), bendamustine + rituximab (CLL10), obinutuzumab + chlorambucil and rituximab + chlorambucil (CLL11), and ofatumumab + chlorambucil (COMPLEMENT-1). Median age across studies was 61-74 years, with older populations receiving ibrutinib, obinutuzumab + chlorambucil, or rituximab + chlorambucil. Median follow-up varied across studies/regimens (range 14.5-37.4 months). Among all patients, PFS appeared longer with ibrutinib relative to CIT and OS appeared comparable. Relative to CIT studies that similarly excluded patients with del(17p) (CLL10) or enrolled older/less-fit patients (CLL11), PFS appeared favorable for ibrutinib in high-risk subgroups, including advanced disease, bulky lymph nodes, unmutated IGHV status, and presence of del(11q). Grade ≥ 3 infections ranged from 9% (ofatumumab + chlorambucil) to 40% (fludarabine + cyclophosphamide + rituximab), and was 25% with ibrutinib. Grade ≥ 3 neutropenia was 12% for ibrutinib and 26%-84% for CIT. Although definitive conclusions cannot be made due to inherent limitations of cross-trial comparisons, this report suggests that ibrutinib has a favorable benefit/risk profile and may potentially eliminate the need for chemotherapy in some patients. Randomized, comparative studies are needed to support these findings.
Published: 2018

225. Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

Author: Hacken, Elisa ten, Valentin, Rebecca, Regis, Fara Faye D, Sun, Jing, Yin, Shanye, Werner, Lillian, Deng, Jing, Gruber, Michaela, Wong, Jessica, Zheng, Mei, Gill, Amy L, Seiler, Michael, Smith, Peter, Thomas, Michael, Buonamici, Silvia, Ghia, Emanuela M, Kim, Ekaterina, Rassenti, Laura Z, Burger, Jan A, Kipps, Thomas J, Meyerson, Matthew L, Bachireddy, Pavan, Wang, Lili, Reed, Robin, Neuberg, Donna, Carrasco, Ruben D, Brooks, Angela N, Letai, Anthony, Davids, Matthew S, and Wu, Catherine J
Subjects: Hematology, Genetics, Cancer, Rare Diseases, Orphan Drug, Clinical Research, Lymphoma, Adult, Aged, Aged, 80 and over, Alternative Splicing, Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Bridged Bicyclo Compounds, Heterocyclic, Disease Models, Animal, Drug Resistance, Neoplasm, Drug Screening Assays, Antitumor, Epoxy Compounds, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Macrolides, Male, Mice, Mice, Transgenic, Middle Aged, Mitochondria, Mutation, Myeloid Cell Leukemia Sequence 1 Protein, Phosphoproteins, Primary Cell Culture, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Pyrimidines, RNA Splicing Factors, Spliceosomes, Sulfonamides, Thiophenes, Apoptosis inhibitors, Therapeutics, Transcription
Abstract: The identification of targetable vulnerabilities in the context of therapeutic resistance is a key challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic feature of chronic lymphocytic leukemia (CLL), irrespective of splicing factor mutation status, which was associated with sensitivity to the spliceosome modulator, E7107. Splicing modulation affected CLL survival pathways, including members of the B cell lymphoma-2 (BCL2) family of proteins, remodeling antiapoptotic dependencies of human and murine CLL cells. E7107 treatment decreased myeloid cell leukemia-1 (MCL1) dependence and increased BCL2 dependence, sensitizing primary human CLL cells and venetoclax-resistant CLL-like cells from an Eμ-TCL1-based adoptive transfer murine model to treatment with the BCL2 inhibitor venetoclax. Our data provide preclinical rationale to support the combination of venetoclax with splicing modulators to reprogram apoptotic dependencies in CLL for treating venetoclax-resistant CLL cases.
Published: 2018

226. Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2

Author: Barr, Paul M, Robak, Tadeusz, Owen, Carolyn, Tedeschi, Alessandra, Bairey, Osnat, Bartlett, Nancy L, Burger, Jan A, Hillmen, Peter, Coutre, Steven, Devereux, Stephen, Grosicki, Sebastian, McCarthy, Helen, Li, Jianyong, Simpson, David, Offner, Fritz, Moreno, Carol, Zhou, Cathy, Styles, Lori, James, Danelle, Kipps, Thomas J, and Ghia, Paolo
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Aging, Clinical Research, Clinical Trials and Supportive Activities, Hematology, Cancer, Rare Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adenine, Aged, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Female, Follow-Up Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Molecular Targeted Therapy, Mutation, Neoplasm Staging, Piperidines, Prognosis, Protein Kinase Inhibitors, Pyrazoles, Pyrimidines, Treatment Outcome, Immunology
Abstract: Results of RESONATE-2 (PCYC-1115/1116) supported approval of ibrutinib for first-line treatment of chronic lymphocytic leukemia. Extended analysis of RESONATE-2 was conducted to determine long-term efficacy and safety of ibrutinib in older patients with chronic lymphocytic leukemia. A total of 269 patients aged ≥65 years with previously untreated chronic lymphocytic leukemia without del(17p) were randomized 1:1 to ibrutinib (n=136) or chlorambucil (n=133) on days 1 and 15 of a 28-day cycle for 12 cycles. Median ibrutinib treatment duration was 28.5 months. Ibrutinib significantly prolonged progression-free survival versus chlorambucil (median, not reached vs 15 months; hazard ratio, 0.12; 95% confidence interval, 0.07-0.20; P
Published: 2018

227. Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia

Author: Choi, Michael Y, Widhopf, George F, Ghia, Emanuela M, Kidwell, Reilly L, Hasan, Kamrul, Yu, Jian, Rassenti, Laura Z, Chen, Liguang, Chen, Yun, Pittman, Emily, Pu, Minya, Messer, Karen, Prussak, Charles E, Castro, Januario E, Jamieson, Catriona, and Kipps, Thomas J
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Hematology, Stem Cell Research - Nonembryonic - Human, Orphan Drug, Cancer, Lymphoma, Stem Cell Research, Rare Diseases, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Antibodies, Monoclonal, Humanized, Dose-Response Relationship, Drug, Drug Tolerance, Humans, Infusions, Intravenous, Leukemia, Lymphocytic, Chronic, B-Cell, Receptor Tyrosine Kinase-like Orphan Receptors, Signal Transduction, Structure-Activity Relationship, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract: Cirmtuzumab is a humanized monoclonal antibody (mAb) that targets ROR1, an oncoembryonic orphan receptor for Wnt5a found on cancer stem cells (CSCs). Aberrant expression of ROR1 is seen in many malignancies and has been linked to Rho-GTPase activation and cancer stem cell self-renewal. For patients with chronic lymphocytic leukemia (CLL), self-renewing, neoplastic B cells express ROR1 in 95% of cases. High-level leukemia cell expression of ROR1 is associated with an unfavorable prognosis. We conducted a phase 1 study involving 26 patients with progressive, relapsed, or refractory CLL. Patients received four biweekly infusions, with doses ranging from 0.015 to 20 mg/kg. Cirmtuzumab had a long plasma half-life and did not have dose-limiting toxicity. Inhibition of ROR1 signaling was observed, including decreased activation of RhoA and HS1. Transcriptome analyses showed that therapy inhibited CLL stemness gene expression signatures in vivo. Cirmtuzumab is safe and effective at inhibiting tumor cell ROR1 signaling in patients with CLL.
Published: 2018

228. Distinct Immunogenetic Profiles of Chronic Lymphocytic Leukemia in Asia: A Taiwan Cooperative Oncology Group Registry Study

Author: Chi-Yuan Yao, Andreas Agathangelidis, Shih-Sung Chuang, Hsiao-Hui Tsou, Wei-Lien Feng, Ta-Chih Liu, Tsai-Yun Chen, Yuan-Bin Yu, Su-Peng Yeh, Ming Yao, Chuan-Cheng Wang, Johnson Lin, Wen-Li Hwang, Jyh-Pyng Gau, Wen-Chien Chou, Tsu-Yi Chao, Liang-In Lin, Hwei-Fang Tien, Paolo Ghia, and Shang-Ju Wu
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Asian patientswith chronic lymphocytic leukemia (CLL) exhibit immunoglobulin heavy variable (IGHV) gene repertoires that are distinct from those observed in Western populations, and a higher proportion of Asian CLL patients carry heavy loads of somatic hypermutations (SHM) within the B-cell receptor immunoglobulins (BcR IG). Due to the low regional incidence of CLL in Asia, only a limited number of studies had attempted to probe the phenomenon of BcR IG stereotypy in Asian populations. In this study, we analyzed the IGHV-IGHD-IGHJ gene rearrangements from a series of 255 CLL patients recruited in a nationwide, multicenter study in Taiwan. Our analysis revealed that the IGHV gene repertoire was characterized by evident biases, with IGHV3-7, IGHV4-34, and IGHV3-23 being the most frequent rearranged IGHV genes, and a higher proportion of cases carrying mutated IGHV. In terms of BcR stereotypy, the incidence of major subsets was less frequent in this cohort, with subsets #77 and #28A being the most common, while the incidence of minor subsets was approximately equivalent to that reported in the Western cohorts. With this study, we provide evidence that CLL in Asia is indeed associated with distinct immunogenetic characteristics regarding IGHV gene usage, SHM status, and BcR IG stereotypy.
Published: 2022
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229. Acalabrutinib Versus Investigator’s Choice in Relapsed/Refractory Chronic Lymphocytic Leukemia: Final ASCEND Trial Results

Author: Paolo Ghia, Andrzej Pluta, Małgorzata Wach, Daniel Lysak, Martin Šimkovič, Iryna Kriachok, Árpád Illés, Javier de la Serna, Sean Dolan, Philip Campbell, Gerardo Musuraca, Abraham Jacob, Eric J. Avery, Jae Hoon Lee, Ganna Usenko, Min Hui Wang, Ting Yu, and Wojciech Jurczak
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Acalabrutinib is a Bruton tyrosine kinase inhibitor approved for patients with chronic lymphocytic leukemia (CLL). ASCEND is the pivotal phase 3 study of acalabrutinib versus investigator’s choice of idelalisib plus rituximab (IdR) or bendamustine plus rituximab (BR) in patients with relapsed/refractory (R/R) CLL. In the primary ASCEND analysis (median 16.1-month follow-up), acalabrutinib showed superior efficacy with an acceptable tolerability profile versus IdR/BR; here, we report final ~4 year follow-up results. Patients with R/R CLL received oral acalabrutinib 100 mg twice daily until progression or unacceptable toxicity, or investigator’s choice of IdR or BR. A total of 310 patients (acalabrutinib, n = 155; IdR, n = 119; BR, n = 36) were enrolled. At median follow-up of 46.5 months (acalabrutinib) and 45.3 months (IdR/BR), acalabrutinib significantly prolonged investigator-assessed progression-free survival (PFS) versus IdR/BR (median, not reached [NR] vs 16.8 months; P < 0.001); 42-month PFS rates were 62% (acalabrutinib) versus 19% (IdR/BR). Median overall survival (OS) was NR (both arms); 42-month OS rates were 78% (acalabrutinib) versus 65% (IdR/BR). Adverse events led to drug discontinuation in 23%, 67%, and 17% of patients in the acalabrutinib, IdR, and BR arms, respectively. Events of clinical interest (acalabrutinib vs IdR/BR) included all-grade atrial fibrillation/flutter (8% vs 3%), all-grade hypertension (8% vs 5%), all-grade major hemorrhage (3% vs 3%), grade ≥3 infections (29% vs 29%), and second primary malignancies excluding nonmelanoma skin cancer (7% vs 2%). At ~4 years follow-up, acalabrutinib maintained favorable efficacy versus standard-of-care regimens and a consistent tolerability profile in patients with R/R CLL.
Published: 2022
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230. Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells

Author: Yu, J, Chen, L, Chen, Y, Hasan, MK, Ghia, EM, Zhang, L, Wu, R, Rassenti, LZ, Widhopf, GF, Shen, Z, Briggs, SP, and Kipps, TJ
Subjects: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Hematology, Cancer, Clinical Research, Lymphoma, Rare Diseases, 14-3-3 Proteins, Adoptive Transfer, Amino Acid Motifs, Animals, Binding Sites, Cell Proliferation, Cells, Cultured, Chemotaxis, Disease Models, Animal, Disease Progression, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Mice, Mice, Knockout, Protein Binding, Receptor Tyrosine Kinase-like Orphan Receptors, Rho Guanine Nucleotide Exchange Factors, Wnt-5a Protein, Immunology, Cardiovascular medicine and haematology, Clinical sciences, Oncology and carcinogenesis
Abstract: Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune precipitates of Wnt5a-activated ROR1 identified 14-3-3ζ, which was confirmed by co-immunoprecipitation. The capacity of Wnt5a to induce ROR1 to complex with 14-3-3ζ could be blocked in CLL cells by treatment with cirmtuzumab, a humanized mAb targeting ROR1. Silencing 14-3-3ζ via small interfering RNA impaired the capacity of Wnt5a to: (1) induce recruitment of ARHGEF2 to ROR1, (2) enhance in vitro exchange activity of ARHGEF2 and (3) induce activation of RhoA and Rac1 in CLL cells. Furthermore, CRISPR/Cas9 deletion of 14-3-3ζ in ROR1-negative CLL cell-line MEC1, and in MEC1 cells transfected to express ROR1 (MEC1-ROR1), demonstrated that 14-3-3ζ was necessary for the growth/engraftment advantage of MEC1-ROR1 over MEC1 cells. We identified a binding motif (RSPS857SAS) in ROR1 for 14-3-3ζ. Site-directed mutagenesis of ROR1 demonstrated that serine-857 was required for the recruitment of 14-3-3ζ and ARHGEF2 to ROR1, and activation of RhoA and Rac1. Collectively, this study reveals that 14-3-3ζ plays a critical role in Wnt5a/ROR1 signaling, leading to enhanced CLL migration and proliferation.
Published: 2017

231. Acalabrutinib monotherapy for treatment of chronic lymphocytic leukaemia (ACE-CL-001): analysis of the Richter transformation cohort of an open-label, single-arm, phase 1–2 study

Author: Eyre, Toby A, Schuh, Anna, Wierda, William G, Brown, Jennifer R, Ghia, Paolo, Pagel, John M, Furman, Richard R, Cheung, Jean, Hamdy, Ahmed, Izumi, Raquel, Patel, Priti, Wang, Min Hui, Xu, Yan, Byrd, John C, and Hillmen, Peter
Published: 2021
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232. Treatment Sequencing in Chronic Lymphocytic Leukemia in 2024: Where We Are and Where We Are Headed

Author: Fresa, Alberto, primary, Innocenti, Idanna, additional, Tomasso, Annamaria, additional, Stirparo, Luca, additional, Mosca, Antonio, additional, Iadevaia, Francesco, additional, Autore, Francesco, additional, Ghia, Paolo, additional, and Laurenti, Luca, additional
Published: 2024
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233. Outcomes and Pattern of Care for Spinal Myxopapillary Ependymoma in the Modern Era—A Population-Based Observational Study

Author: Wang, Chenyang, primary, Rooney, Michael K., additional, Alvarez-Breckenridge, Christopher, additional, Beckham, Thomas H., additional, Chung, Caroline, additional, De, Brian S., additional, Ghia, Amol J., additional, Grosshans, David, additional, Majd, Nazanin K., additional, McAleer, Mary F., additional, McGovern, Susan L., additional, North, Robert Y., additional, Paulino, Arnold C., additional, Perni, Subha, additional, Reddy, Jay P., additional, Rhines, Laurence D., additional, Swanson, Todd A., additional, Tatsui, Claudio E., additional, Tom, Martin C., additional, Yeboa, Debra N., additional, and Li, Jing, additional
Published: 2024
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234. First‐line ibrutinib treatment in patients with chronic lymphocytic leukemia is associated with overall survival rates similar to those of an age‐matched general population: A pooled post hoc analysis

Author: Ghia, Paolo, primary, Owen, Carolyn, additional, Allan, John N., additional, Barrientos, Jacqueline C., additional, Barr, Paul M., additional, Shi, Chunxue, additional, Szoke, Anita, additional, Abbazio, Christopher, additional, Krigsfeld, Gabriel S., additional, and Burger, Jan A., additional
Published: 2024
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235. The energy spectrum of cosmic rays beyond the turn-down around $$\varvec{10^{17}}$$ 10 17 eV as measured with the surface detector of the Pierre Auger Observatory

Author: P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez-Muñiz, R. Alves Batista, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, K. S. Caballero-Mora, L. Caccianiga, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, M. del Río, O. Deligny, A. Di Matteo, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, D. dos Santos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, T. Fodran, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, N. Karastathis, B. Keilhauer, J. Kemp, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, N. Kunka, B. L. Lago, R. G. Lang, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, J. Pawlowsky, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, M. Perlin, L. Perrone, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schulte, A. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, H. Wahlberg, C. Watanabe, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, and Pierre Auger Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.
Published: 2021
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236. Use of Serratus Anterior Plane and Transversus Thoracis Plane Blocks for Subcutaneous Implantable Cardioverter-Defibrillator (S-ICD) Implantation Decreases Intraoperative Opioid Requirements

Author: Shariat, Ali, Ghia, Samit, Gui, Jane L., Gallombardo, Joseph, Bracker, Joseph, Lin, Hung-Mo, Mohammad, Asad, Mehta, Davendra, and Bhatt, Himani
Published: 2021
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237. IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Author: Maity, Palash C., Bilal, Mayas, Koning, Marvyn T., Young, Marc, van Bergen, Cornelis A. M., Renna, Valerio, Nicolò, Antonella, Datta, Moumita, Gentner-Göbel, Eva, Barendse, Rob S., Somers, Sebastiaan F., de Groen, Ruben A. L., Vermaat, Joost S. P., Steinbrecher, Daniela, Schneider, Christof, Tausch, Eugen, Bittolo, Tamara, Bomben, Riccardo, Mazzarello, Andrea Nicola, del Poeta, Giovanni, Kroes, Wilma G. M., van Wezel, J. Tom, Imkeller, Katharina, Busse, Christian E., Degano, Massimo, Bakchoul, Tamam, Schulz, Axel Ronald, Mei, Henrik, Ghia, Paolo, Kotta, Konstantia, Stamatopoulos, Kostas, Wardemann, Hedda, Zucchetto, Antonella, Chiorazzi, Nicholas, Gattei, Valter, Stilgenbauer, Stephan, Veelken, Hendrik, and Jumaa, Hassan
Published: 2020

238. Pooled analysis of safety data from clinical trials evaluating acalabrutinib monotherapy in mature B-cell malignancies

Author: Furman, Richard R., Byrd, John C., Owen, Roger G., O’Brien, Susan M., Brown, Jennifer R., Hillmen, Peter, Stephens, Deborah M., Chernyukhin, Nataliya, Lezhava, Tamara, Hamdy, Ahmed M., Izumi, Raquel, Patel, Priti, Baek, Marshall, Christian, Beth, Dyer, Martin J. S., Streetly, Matthew J., Sun, Clare, Rule, Simon, Wang, Michael, Ghia, Paolo, Jurczak, Wojciech, Pagel, John M., and Sharman, Jeff P.
Published: 2021
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239. Measurable residual disease in chronic lymphocytic leukemia: expert review and consensus recommendations

Author: Wierda, William G., Rawstron, Andrew, Cymbalista, Florence, Badoux, Xavier, Rossi, Davide, Brown, Jennifer R., Egle, Alexander, Abello, Virginia, Cervera Ceballos, Eduardo, Herishanu, Yair, Mulligan, Stephen P., Niemann, Carsten U., Diong, Colin P., Soysal, Teoman, Suzuki, Ritsuro, Tran, Hoa T. T., Wu, Shang-Ju, Owen, Carolyn, Stilgenbauer, Stephan, Ghia, Paolo, and Hillmen, Peter
Published: 2021
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240. Higher education expansion and graduate labour market outcomes in Spain : overqualification and its discontents

Author: Osseiran, Ghia, Mayhew, Ken, and Holmes, Craig
Subjects: 378.1
Abstract: This is a mixed methods study about graduate educational and skill mismatch in Spain. The study examines the evolution of graduate mismatch at the macro level, investigating changes in the number of tertiary graduates vis-à-vis-the number of high-skilled jobs in the economy. The proliferation in the share of graduates unable to find high-skilled jobs in Spain has accentuated policy concerns that the number of graduates has increased faster than the number of high-skilled occupations available. Graduates are consequently "bumped down" the occupational ladder and forced to take up lower-skilled jobs, a situation defined in this thesis as occupational drifting down. The first part of this thesis is dedicated to exploring the determinants of graduate labour market mismatch, with focus on the influence of educational track and field of study on the probability of graduate employment and occupational drifting down. Drawing on the Spanish Labour Force Survey for 2006 and 2012, this study provides an original analysis of the determinants of employment and occupational drifting down among Spanish graduates, employing logistic models to evaluate the influence of personal, educational and occupational characteristics. The fact that these graduates are employed in jobs that one generation ago were occupied by non-graduates, however, does not automatically indicate that the demands of these occupations has remained the same. Since job content is not fixed, the quantitative methods employed in this thesis alone are insufficient to determine the skill requirements of occupations and changes in job content over time. This study, therefore, uses the multiple-case study approach to investigate changing skill requirements within occupations. To this end, 50 in-depth interviews with senior managers and graduates in the retail banking and retail trade industries were conducted in Spain between January 2015 and March 2016. In gaining proximity to the real-life context of graduate mismatch in the workplace, this study seeks to advance scholarship on graduate skills utilization and hiring trends at the sectoral level, providing novel insight into the changing skill requirements of two industries in Spain. In this way, this study fills a research gap, as sectoral case studies are sparse in the literature (Caroli et al., 2008; Elias and Purcell, 2004; Mason, 2002; Green and McIntosh, 2002, Knights and McCabe, 1998, Mason, 1996), particularly for Spain.
Published: 2017

241. Multi-resolution anisotropy studies of ultrahigh-energy cosmic rays detected at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report a multi-resolution search for anisotropies in the arrival directions of cosmic rays detected at the Pierre Auger Observatory with local zenith angles up to $80^\circ$ and energies in excess of 4 EeV ($4 \times 10^{18}$ eV). This search is conducted by measuring the angular power spectrum and performing a needlet wavelet analysis in two independent energy ranges. Both analyses are complementary since the angular power spectrum achieves a better performance in identifying large-scale patterns while the needlet wavelet analysis, considering the parameters used in this work, presents a higher efficiency in detecting smaller-scale anisotropies, potentially providing directional information on any observed anisotropies. No deviation from isotropy is observed on any angular scale in the energy range between 4 and 8 EeV. Above 8 EeV, an indication for a dipole moment is captured; while no other deviation from isotropy is observed for moments beyond the dipole one. The corresponding $p$-values obtained after accounting for searches blindly performed at several angular scales, are $1.3 \times 10^{-5}$ in the case of the angular power spectrum, and $2.5 \times 10^{-3}$ in the case of the needlet analysis. While these results are consistent with previous reports making use of the same data set, they provide extensions of the previous works through the thorough scans of the angular scales., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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242. Testing Hadronic Interactions at Ultrahigh Energies with Air Showers Measured by the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allen, J., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gallo, F., García, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pepe, I. M., Pereira, L. A. S., Perrone, L., Petermann, E., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Strafella, F., Stutz, A., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yelos, D., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: Ultrahigh energy cosmic ray air showers probe particle physics at energies beyond the reach of accelerators. Here we introduce a new method to test hadronic interaction models without relying on the absolute energy calibration, and apply it to events with primary energy 6-16 EeV (E_CM = 110-170 TeV), whose longitudinal development and lateral distribution were simultaneously measured by the Pierre Auger Observatory. The average hadronic shower is 1.33 +- 0.16 (1.61 +- 0.21) times larger than predicted using the leading LHC-tuned models EPOS-LHC (QGSJetII-04), with a corresponding excess of muons., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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243. Evidence for a mixed mass composition at the `ankle' in the cosmic-ray spectrum

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollant, R., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Younk, P., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report a first measurement for ultra-high energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the `ankle' at $\lg(E/{\rm eV})=18.5-19.0$ differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass $A > 4$. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavoured as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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244. Search for ultrarelativistic magnetic monopoles with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a search for ultra-relativistic magnetic monopoles with the Pierre Auger Observatory. Such particles, possibly a relic of phase transitions in the early universe, would deposit a large amount of energy along their path through the atmosphere, comparable to that of ultrahigh-energy cosmic rays (UHECRs). The air shower profile of a magnetic monopole can be effectively distinguished by the fluorescence detector from that of standard UHECRs. No candidate was found in the data collected between 2004 and 2012, with an expected background of less than 0.1 event from UHECRs. The corresponding 90% confidence level (C.L.) upper limits on the flux of ultra-relativistic magnetic monopoles range from $10^{-19}$ (cm$^{2}$ sr s)$^{-1}$ for a Lorentz factor $\gamma=10^9$ to $2.5 \times10^{-21}$ (cm$^{2}$ sr s)$^{-1}$ for $\gamma=10^{12}$. These results - the first obtained with a UHECR detector - improve previously published limits by up to an order of magnitude., Comment: Published version. Corrected title. Added journal reference and DOI. Added Report Number
Published: 2016
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245. Ultrahigh-energy neutrino follow-up of Gravitational Wave events GW150914 and GW151226 with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: On September 14, 2015 the Advanced LIGO detectors observed their first gravitational-wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy above 100 PeV from point-like sources across the sky with equatorial declination from about -65 deg. to +60 deg., and in particular from a fraction of the 90% confidence-level (CL) inferred positions in the sky of GW150914 and GW151226. A targeted search for highly-inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth's crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within $\pm 500$ s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. From the non-observation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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246. Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

Author: The Pierre Auger Collaboration, Aab, Alexander, Abreu, Pedro, Aglietta, Marco, Ahn, Eun-Joo, Samarai, Imen Al, Albuquerque, Ivone, Allekotte, Ingomar, Allison, Patrick, Almela, Alejandro, Castillo, Jesus Alvarez, Alvarez-Muñiz, Jaime, Batista, Rafael Alves, Ambrosio, Michelangelo, Aminaei, Amin, Anastasi, Gioacchino Alex, Anchordoqui, Luis, Andringa, Sofia, Aramo, Carla, Arqueros, Fernando, Arsene, Nicusor, Asorey, Hernán Gonzalo, Assis, Pedro, Aublin, Julien, Avila, Gualberto, Awal, Nafiun, Badescu, Alina Mihaela, Baus, Colin, Beatty, Jim, Becker, Karl Heinz, Bellido, Jose A., Berat, Corinne, Bertaina, Mario Edoardo, Bertou, Xavier, Biermann, Peter, Billoir, Pierre, Blaess, Simon G., Blanco, Alberto, Blanco, Miguel, Blazek, Jiri, Bleve, Carla, Blümer, Hans, Boháčová, Martina, Boncioli, Denise, Bonifazi, Carla, Borodai, Nataliia, Brack, Jeffrey, Brancus, Iliana, Bretz, Thomas, Bridgeman, Ariel, Brogueira, Pedro, Buchholz, Peter, Bueno, Antonio, Buitink, Stijn, Buscemi, Mario, Caballero-Mora, Karen S., Caccianiga, Barbara, Caccianiga, Lorenzo, Candusso, Marina, Caramete, Laurentiu, Caruso, Rossella, Castellina, Antonella, Cataldi, Gabriella, Cazon, Lorenzo, Cester, Rosanna, Chavez, Alan G., Chiavassa, Andrea, Chinellato, Jose Augusto, Chudoba, Jiri, Cilmo, Marco, Clay, Roger W, Cocciolo, Giuseppe, Colalillo, Roberta, Coleman, Alan, Collica, Laura, Coluccia, Maria Rita, Conceição, Ruben, Contreras, Fernando, Cooper, Mathew J., Cordier, Alain, Coutu, Stephane, Covault, Corbin, Cronin, James, Dallier, Richard, Daniel, Bruno, Dasso, Sergio, Daumiller, Kai, Dawson, Bruce R., de Almeida, Rogerio M., de Jong, Sijbrand J., De Mauro, Giuseppe, Neto, Joao de Mello, De Mitri, Ivan, de Oliveira, Jaime, de Souza, Vitor, del Peral, Luis, Deligny, Olivier, Dhital, Niraj, Di Giulio, Claudio, Di Matteo, Armando, Diaz, Johana Chirinos, Castro, Mary Lucia Díaz, Diogo, Francisco, Dobrigkeit, Carola, Docters, Wendy, D'Olivo, Juan Carlos, Dorofeev, Alexei, Hasankiadeh, Qader Dorosti, Anjos, Rita dos, Dova, Maria Teresa, Ebr, Jan, Engel, Ralph, Erdmann, Martin, Erfani, Mona, Escobar, Carlos O., Espadanal, Joao, Etchegoyen, Alberto, Falcke, Heino, Fang, Ke, Farrar, Glennys, Fauth, Anderson, Fazzini, Norberto, Ferguson, Andrew P., Fick, Brian, Figueira, Juan Manuel, Filevich, Alberto, Filipčič, Andrej, Fratu, Octavian, Freire, Martín Miguel, Fujii, Toshihiro, García, Beatriz, Garcia-Gamez, Diego, Garcia-Pinto, Diego, Gate, Florian, Gemmeke, Hartmut, Gherghel-Lascu, Alexandru, Ghia, Piera Luisa, Giaccari, Ugo, Giammarchi, Marco, Giller, Maria, Głas, Dariusz, Glaser, Christian, Glass, Henry, Golup, Geraldina, Berisso, Mariano Gómez, Vitale, Primo F. Gómez, González, Nicolás, Gookin, Ben, Gordon, Jacob, Gorgi, Alessio, Gorham, Peter, Gouffon, Philippe, Griffith, Nathan, Grillo, Aurelio, Grubb, Trent D., Guarino, Fausto, Guedes, Germano, Hampel, Matías Rolf, Hansen, Patricia, Harari, Diego, Harrison, Thomas A., Hartmann, Sebastian, Harton, John, Haungs, Andreas, Hebbeker, Thomas, Heck, Dieter, Heimann, Philipp, Herve, Alexander E., Hill, Gary C., Hojvat, Carlos, Hollon, Nicholas, Holt, Ewa, Homola, Piotr, Hörandel, Jörg, Horvath, Pavel, Hrabovský, Miroslav, Huber, Daniel, Huege, Tim, Insolia, Antonio, Isar, Paula Gina, Jandt, Ingolf, Jansen, Stefan, Jarne, Cecilia, Johnsen, Jeffrey A., Josebachuili, Mariela, Kääpä, Alex, Kambeitz, Olga, Kampert, Karl Heinz, Kasper, Peter, Katkov, Igor, Keilhauer, Bianca, Kemp, Ernesto, Kieckhafer, Roger, Klages, Hans, Kleifges, Matthias, Kleinfeller, Jonny, Krause, Raphael, Krohm, Nicole, Kuempel, Daniel, Mezek, Gasper Kukec, Kunka, Norbert, Awad, Alaa Metwaly Kuotb, LaHurd, Danielle, Latronico, Luca, Lauer, Robert, Lauscher, Markus, Lautridou, Pascal, Coz, Sandra Le, Lebrun, Didier, Lebrun, Paul, de Oliveira, Marcelo Augusto Leigui, Letessier-Selvon, Antoine, Lhenry-Yvon, Isabelle, Link, Katrin, Lopes, Luis, López, Rebeca, Casado, Aida López, Louedec, Karim, Lucero, Agustin, Malacari, Max, Mallamaci, Manuela, Maller, Jennifer, Mandat, Dusan, Mantsch, Paul, Mariazzi, Analisa, Marin, Vincent, Mariş, Ioana, Marsella, Giovanni, Martello, Daniele, Martinez, Humberto, Bravo, Oscar Martínez, Martraire, Diane, Meza, Jimmy Masías, Mathes, Hermann-Josef, Mathys, Sebastian, Matthews, James, Matthews, John, Matthiae, Giorgio, Maurizio, Daniela, Mayotte, Eric, Mazur, Peter, Medina, Carlos, Medina-Tanco, Gustavo, Meissner, Rebecca, Mello, Victor, Melo, Diego, Menshikov, Alexander, Messina, Stefano, Micheletti, Maria Isabel, Middendorf, Lukas, Minaya, Ignacio A., Miramonti, Lino, Mitrica, Bogdan, Molina-Bueno, Laura, Mollerach, Silvia, Montanet, François, Morello, Carlo, Mostafá, Miguel, Moura, Celio A., Muller, Marcio Aparecido, Müller, Gero, Müller, Sarah, Navas, Sergio, Necesal, Petr, Nellen, Lukas, Nelles, Anna, Neuser, Jens, Nguyen, Phong H., Niculescu-Oglinzanu, Mihai, Niechciol, Marcus, Niemietz, Lukas, Niggemann, Tim, Nitz, Dave, Nosek, Dalibor, Novotny, Vladimir, Nožka, Lyberis, Núñez, Luis, Ochilo, Livingstone, Oikonomou, Foteini, Olinto, Angela, Pacheco, Noelia, Selmi-Dei, Daniel Pakk, Palatka, Miroslav, Pallotta, Juan, Papenbreer, Philipp, Parente, Gonzalo, Parra, Alejandra, Paul, Thomas, Pech, Miroslav, Pękala, Jan, Pelayo, Rodrigo, Pepe, Iuri, Perrone, Lorenzo, Petermann, Emily, Peters, Christine, Petrera, Sergio, Petrov, Yevgeniy, Phuntsok, Jamyang, Piegaia, Ricardo, Pierog, Tanguy, Pieroni, Pablo, Pimenta, Mário, Pirronello, Valerio, Platino, Manuel, Plum, Matthias, Porcelli, Alessio, Porowski, Czeslaw, Prado, Raul Ribeiro, Privitera, Paolo, Prouza, Michael, Quel, Eduardo J, Querchfeld, Sven, Quinn, Sean, Rautenberg, Julian, Ravel, Olivier, Ravignani, Diego, Reinert, Darius, Revenu, Benoît, Ridky, Jan, Risse, Markus, Ristori, Pablo, Rizi, Vincenzo, de Carvalho, Washington Rodrigues, Rojo, Jorge Rubén Rodriguez, Rodríguez-Frías, Maria Dolores, Rogozin, Dmytro, Rosado, Jaime, Roth, Markus, Roulet, Esteban, Rovero, Adrian, Saffi, Steven J., Saftoiu, Alexandra, Salazar, Humberto, Saleh, Ahmed, Greus, Francisco Salesa, Salina, Gaetano, Gomez, Jose Sanabria, Sánchez, Federico, Sanchez-Lucas, Patricia, Santos, Edivaldo Moura, Santos, Eva, Sarazin, Fred, Sarkar, Biswaijt, Sarmento, Raul, Sarmiento-Cano, Christian, Sato, Ricardo, Scarso, Carlos, Schauer, Markus, Scherini, Viviana, Schieler, Harald, Schmidt, David, Scholten, Olaf, Schoorlemmer, Harm, Schovánek, Petr, Schröder, Frank G., Schulz, Alexander, Schulz, Johannes, Schumacher, Johannes, Sciutto, Sergio, Segreto, Alberto, Settimo, Mariangela, Shadkam, Amir, Shellard, Ronald C., Sigl, Guenter, Sima, Octavian, Śmiałkowski, Andrzej, Šmída, Radomir, Snow, Gregory, Sommers, Paul, Sonntag, Sebastian, Sorokin, J., Squartini, Ruben, Srivastava, Yogendra N., Stanca, Denis, Stanič, Samo, Stapleton, James, Stasielak, Jaroslaw, Stephan, Maurice, Stutz, Anne, Suarez, Federico, Durán, Mauricio Suarez, Suomijärvi, Tiina, Supanitsky, A. Daniel, Sutherland, Michael, Swain, John, Szadkowski, Zbigniew, Taborda, Oscar Alejandro, Tapia, Alex, Tepe, Andreas, Theodoro, Vanessa Menezes, Timmermans, Charles, Peixoto, Carlos J. Todero, Toma, Gabriel, Tomankova, Lenka, Tomé, Bernardo, Tonachini, Aurelio, Elipe, Guillermo Torralba, Machado, Diego Torres, Travnicek, Petr, Trini, Marta, Ulrich, Ralf, Unger, Michael, Urban, Martin, Galicia, Jose F. Valdés, Valiño, Ines, Valore, Laura, van Aar, Guus, van Bodegom, Patrick, Berg, Ad M. van den, van Velzen, Sjoert, van Vliet, Arjen, Varela, Enrique, Cárdenas, Bernardo Vargas, Varner, Gary, Vasquez, Rafael, Vázquez, Jose R., Vázquez, Ricardo, Veberič, Darko, Verzi, Valerio, Vicha, Jakub, Videla, Mariela, Villaseñor, Luis, Vlcek, Brian, Vorobiov, Serguei, Wahlberg, Hernan, Wainberg, Oscar, Walz, David, Watson, Alan, Weber, Marc, Weidenhaupt, Klaus, Weindl, Andreas, Welling, Christoph, Werner, Felix, Widom, Allan, Wiencke, Lawrence, Wilczyński, Henryk, Winchen, Tobias, Wittkowski, David, Wundheiler, Brian, Wykes, Sarka, Yang, Lili, Yapici, Tolga, Yushkov, Alexey, Zas, Enrique, Zavrtanik, Danilo, Zavrtanik, Marko, Zepeda, Arnulfo, Zimmermann, Benedikt, Ziolkowski, Michael, and Zuccarello, Francesca
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory., Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary files
Published: 2016
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247. Prototype muon detectors for the AMIGA component of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Batista, R. Alves, Ambrosio, M., Aminaei, A., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Awal, N., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, A., Blanco, M., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Brogueira, P., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Hasankiadeh, Q. Dorosti, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gallo, F., García, B., García-Gámez, D., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Hervé, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. W. Kuotb, LaHurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Louedec, K., Lucero, A., Malacari, M., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Martraire, D., Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Meissner, R., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Muller, M. A., Müller, G., Müller, S., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pękala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Srivastava, Y. N., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Durán, M. Suarez, Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Tibolla, O., Timmermans, C., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Velzen, S., van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vasquez, R., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Widom, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., and Zuccarello, F.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Auger Muons and Infill for the Ground Array) is an upgrade of the Pierre Auger Observatory to extend its range of detection and to directly measure the muon content of the particle showers. It consists of an infill of surface water-Cherenkov detectors accompanied by buried scintillator detectors used for muon counting. The main objectives of the AMIGA engineering array, referred to as the Unitary Cell, are to identify and resolve all engineering issues as well as to understand the muon-number counting uncertainties related to the design of the detector. The mechanical design, fabrication and deployment processes of the muon counters of the Unitary Cell are described in this document. These muon counters modules comprise sealed PVC casings containing plastic scintillation bars, wavelength-shifter optical fibers, 64 pixel photomultiplier tubes, and acquisition electronics. The modules are buried approximately 2.25 m below ground level in order to minimize contamination from electromagnetic shower particles. The mechanical setup, which allows access to the electronics for maintenance, is also described in addition to tests of the modules' response and integrity. The completed Unitary Cell has measured a number of air showers of which a first analysis of a sample event is included here., Comment: Replaced with published version. Added journal reference and DOI
Published: 2016
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248. The Pierre Auger Observatory Upgrade - Preliminary Design Report

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Batista, R. Alves, Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Awal, N., Badescu, A. M., Barber, K. B., Bäuml, J., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, A., Blanco, M., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Brack, J., Brancus, I., Bridgeman, A., Brogueira, P., Brown, W. C., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., del Peral, L., Deligny, O., Dembinski, H., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Hasankiadeh, Q. Dorosti, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fernandes, M., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fox, B. D., Fratu, O., Freire, M. M., Fuchs, B., Fujii, T., García, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Hemery, N., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Kégl, B., Keilhauer, B., Keivani, A., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Krömer, O., Kuempel, D., Mezek, G. Kukec, Kunka, N., LaHurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Louedec, K., Lu, L., Lucero, A., Malacari, M., Maldera, S., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martin, L., Martinez, H., Bravo, O. Martínez, Martraire, D., Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Meissner, R., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Meyhandan, R., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Muller, M. A., Müller, G., Müller, S., Mussa, R., Navarra, G., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pȩkala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Purrello, V., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sarmento, R., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sidelnik, I., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sorokin, J., Squartini, R., Srivastava, Y. N., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Velzen, S., van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vasquez, R., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Widom, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zhu, Y., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Pierre Auger Observatory has begun a major Upgrade of its already impressive capabilities, with an emphasis on improved mass composition determination using the surface detectors of the Observatory. Known as AugerPrime, the upgrade will include new 4 m$^2$ plastic scintillator detectors on top of all 1660 water-Cherenkov detectors, updated and more flexible surface detector electronics, a large array of buried muon detectors, and an extended duty cycle for operations of the fluorescence detectors. This Preliminary Design Report was produced by the Collaboration in April 2015 as an internal document and information for funding agencies. It outlines the scientific and technical case for AugerPrime. We now release it to the public via the arXiv server. We invite you to review the large number of fundamental results already achieved by the Observatory and our plans for the future., Comment: 201 pages
Published: 2016

249. Azimuthal asymmetry in the risetime of the surface detector signals of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Awal, N., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gallo, F., García, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pepe, I. M., Pereira, L. A. S., Perrone, L., Petermann, E., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Strafella, F., Stutz, A., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The azimuthal asymmetry in the risetime of signals in Auger surface detector stations is a source of information on shower development. The azimuthal asymmetry is due to a combination of the longitudinal evolution of the shower and geometrical effects related to the angles of incidence of the particles into the detectors. The magnitude of the effect depends upon the zenith angle and state of development of the shower and thus provides a novel observable, $(\sec \theta)_\mathrm{max}$, sensitive to the mass composition of cosmic rays above $3 \times 10^{18}$ eV. By comparing measurements with predictions from shower simulations, we find for both of our adopted models of hadronic physics (QGSJETII-04 and EPOS-LHC) an indication that the mean cosmic-ray mass increases slowly with energy, as has been inferred from other studies. However, the mass estimates are dependent on the shower model and on the range of distance from the shower core selected. Thus the method has uncovered further deficiencies in our understanding of shower modelling that must be resolved before the mass composition can be inferred from $(\sec \theta)_\mathrm{max}$., Comment: Replaced with published version. Added journal reference and DOI
Published: 2016
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250. Obinutuzumab plus chlorambucil versus ibrutinib in previously untreated chronic lymphocytic leukemia patients without TP53 disruptions: A real-life CLL campus study

Author: Andrea Visentin, Francesca Romana Mauro, Gioachino Catania, Alberto Fresa, Candida Vitale, Alessandro Sanna, Veronica Mattiello, Francesca Cibien, Paolo Sportoletti, Massimo Gentile, Gian Matteo Rigolin, Francesca Maria Quaglia, Roberta Murru, Alessandro Gozzetti, Stefano Molica, Monia Marchetti, Stefano Pravato, Francesco Angotzi, Alessandro Cellini, Lydia Scarfò, Gianluigi Reda, Marta Coscia, Luca Laurenti, Paolo Ghia, Robin Foà, Antonio Cuneo, and Livio Trentin
Subjects: obinutizumab, ibrutinib, treatment-naive, MRD, economic impact, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: One of the main issues in the treatment of patients with chronic lymphocytic leukemia (CLL) deals with the choice between continuous or fixed-duration therapy. Continuous ibrutinib (IB), the first-in-class BTK inhibitor, and obinutuzumab-chlorambucil (G-CHL) are commonly used therapies for elderly and/or comorbid patients. No head-to-head comparison has been carried out. Within the Italian campus CLL network, we performed a retrospective study on CLL patients without TP53 disruption treated with IB or G-CHL as first-line therapy. Patients in the G-CHL arm had a higher CIRS score and the worst renal function. The overall response rates between the G-CHL and IB arms were similar, but more complete remissions (CRs) were achieved with G-CHL (p = 0.0029). After a median follow-up of 30 months, the progression-free survival (PFS, p = 0.0061) and time to next treatment (TTNT, p = 0.0043), but not overall survival (OS, p = 0.6642), were better with IB than with G-CHL. Similar results were found after propensity score matching and multivariate analysis. While PFS and TTNT were longer with IB than with G-CHL in IGHV unmutated patients (p = 0.0190 and 0.0137), they were superimposable for IGHV mutated patients (p = 0.1900 and 0.1380). In the G-CHL arm, the depth of response (79% vs. 68% vs. 38% for CR, PR and SD/PD; p < 0.0001) and measurable residual disease (MRD) influenced PFS (78% vs. 53% for undetectable MRD vs. detectable MRD, p = 0.0203). Hematological toxicities were common in the G-CHL arm, while IB was associated with higher costs. Although continuous IB provides better disease control in CLL, IGHV mutated patients and those achieving an undetectable MRD show a marked clinical and economic benefit from a fixed-duration obinutuzumab-based treatment.
Published: 2022
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