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841 results on '"Ghezzi, C"'

203. Analyzing refinements of state based specifications: the case of TB nets

Author

Felder, M, Ghezzi, C, Pezze', M, PEZZE', MAURO, Felder, M, Ghezzi, C, Pezze', M, and PEZZE', MAURO

Abstract

We describe how formal specifications given in terms of a high-level timed Petri net formalism (TB nets) can be analyzed to check the temporal properties of bounded invariance (the systems stays in a given state until time &tgr;) and bounded response (the system will enter a given state within time &tgr;). In particular, we concentrate on specifications given in a hierarchical, top-down manner, where one specification level refines a more abstract level. Our goal is to define the conditions under which the properties that are proven to hold at a given abstraction level are preserved at the next refined level. To do so, we define the concept of correct refinement, and we show that bounded invariance and bounded response are preserved by a correct refinement. We also provide a set of constructive rules that may be applied to refine a net in such a way that the resulting net is a correct refinement.

Published
1993

204. Software specialization via symbolic execution

Author

Coen Porisini, A, DE PAOLI, F, Ghezzi, C, Mandrioli, D, Mandrioli, D., DE PAOLI, FLAVIO MARIA, Coen Porisini, A, DE PAOLI, F, Ghezzi, C, Mandrioli, D, Mandrioli, D., and DE PAOLI, FLAVIO MARIA

Abstract

The authors describe a technique and an environment-supporting specialization of generalized software components. The technique is based on symbolic execution. It allows one to transform a generalized software component into a more specific and more efficient component. Specialization is proposed as a technique that improves software reuse. The idea is that a library of generalized components exists and the environment supports a designer in customizing a generalized component when the need arises for reusing it under more restricted conditions. It is also justified as a reengineering technique that helps optimize a program during maintenance. Specialization is supported by an interactive environment that provides several transformation tools: a symbolic executor/simplifier, an optimizer, and a loop refolder. The conceptual basis for these transformation techniques is described, examples of their application are given, and how they cooperate in a prototype environment for the Ada programming language is outlined

Published
1991

205. A unified high-level Petri net formalism for time-critical systems

Author

Ghezzi, C, Mandrioli, D, Morasca, S, Pezze', M, PEZZE', MAURO, Ghezzi, C, Mandrioli, D, Morasca, S, Pezze', M, and PEZZE', MAURO

Abstract

The authors introduce a high-level Petri net formalism-environment/relationship (ER) nets-which can be used to specify control, function, and timing issues. In particular, they discuss how time can be modeled via ER nets by providing a suitable axiomatization. They use ER nets to define a time notation that is shown to generalize most time Petri-net-based formalisms which appeared in the literature. They discuss how ER nets can be used in a specification support environment for a time-critical system and, in particular, the kind of analysis supported.

Published
1991

240. In vivo molecular imaging of myocardial angiogenesis using the alpha(v)beta3 integrin-targeted tracer 99mTc-RAFT-RGD.

Author

Dimastromatteo J, Riou LM, Ahmadi M, Pons G, Pellegrini E, Broisat A, Sancey L, Gavrilina T, Boturyn D, Dumy P, Fagret D, Ghezzi C, Dimastromatteo, Julien, Riou, Laurent M, Ahmadi, Mitra, Pons, Guillaume, Pellegrini, Eric, Broisat, Alexis, Sancey, Lucie, and Gavrilina, Tatiana

Abstract

Background: Myocardial angiogenesis following reperfusion of an infarcted area may impact on patient prognosis and pro-angiogenic treatments are currently evaluated. The non-invasive imaging of angiogenesis would therefore be of potential clinical relevance in these settings. (99m)Tc-RAFT-RGD is a novel (99m)Tc-labeled tracer that targets the alpha(v)beta(3) integrin. Our objective was to determine whether this tracer was suitable for myocardial angiogenesis imaging.Methods and Results: A rat model of reperfused myocardial infarction was employed. Fourteen days following reperfusion, the animals were injected with (99m)Tc-RAFT-RGD or with its negative control (99m)Tc-RAFT-RAD. Fourteen animals were dedicated to autoradiographic imaging, infarct staining, and gamma-well counting of myocardial activity. In vivo dual-isotope pinhole SPECT imaging of (201)Tl and (99m)Tc-RAFT-RGD or (99m)Tc-RAFT-RAD was also performed in 11 additional animals. Neovessels were observed by immunostaining in the infarcted and peri-infarct areas. (99m)Tc-RAFT-RGD infarct-to-normal ratios by gamma-well counting and ex vivo imaging (2.5 +/- 0.6 and 4.9 +/- 0.9, respectively) were significantly higher than those of (99m)Tc-RAFT-RAD (1.7 +/- 0.2 and 2.2 +/- 0.4, respectively, P < .05). The infarcted area was readily visible in vivo by SPECT with (99m)Tc-RAFT-RGD but not with (99m)Tc-RAFT-RAD (infarct-to-normal zone activity ratio, 2.5 +/- 0.6 and 1.7 +/- 0.4, respectively, P < .05).Conclusion: (99m)Tc-RAFT-RGD allowed the experimental in vivo molecular imaging of myocardial angiogenesis. [ABSTRACT FROM AUTHOR]

Published
2010
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