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205. High flow nasal oxygen therapy to avoid intubation in SARS-CoV-2 pneumonia: A multicenter retrospective study

Author

Bonnet, Nicolas, primary, Martin, Olivier, additional, Boubaya, Marouane, additional, Levy, Vincent, additional, Ebstein, Nathan, additional, Karoubi, Philippe, additional, Lambiotte, Yacine Tandjaoui, additional, Meersch, Guillaume Van Der, additional, Oziel, johanna, additional, Soulie, Marie, additional, Ghalayini, Mohamed, additional, Winchenne, Anais, additional, Zahar, Jean Ralph, additional, Ahmed, Passem, additional, Gaudry, Stéphane, additional, and Cohen, Yves, additional

Published
2020
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214. Nutcracker syndrome associated with celiacomesentric trunk anomaly: case report

Author

Radwan Al-Okour, Ibrahim F. Al-Ghalayini, and Nabil A Al-Soubi

Subjects
medicine.medical_specialty, nutcracker syndrome, 030232 urology & nephrology, Case Report, 030204 cardiovascular system & hematology, Asymptomatic, 03 medical and health sciences, Nutcracker syndrome, 0302 clinical medicine, medicine.artery, medicine, Superior mesenteric artery, Mesenteric arteries, Aorta, business.industry, medicine.disease, Trunk, celiacomesenteric trunk, medicine.anatomical_structure, Nephrology, Radiology, hematuria in children, medicine.symptom, business, Rare disease, Artery
Abstract

Introduction Nutcracker syndrome is a rare disease entity that is caused by entrapment of the left renal vein between the aorta and superior mesenteric artery, usually due to abnormal branching of the superior mesenteric artery from the aorta causing renal venous hypertension. The symptoms vary from asymptomatic hematuria to severe pelvic congestion. Celiacomes-enteric trunk anomaly is a rare variation of splanchnic artery anomaly that occurs when the celiac trunk and superior mesenteric arteries have a common origin from the aorta. A disease involving the rarely encountered celiacomesenteric trunk anomaly is extremely uncommon. To our knowledge, association between nutcracker syndrome and celiacomesentric trunk anomaly has not been reported in the literature. Case presentation A 14-year-old boy with no significant past medical history presented with a 3-year painless hematuria. CT-angiogram revealed anterior nutcracker syndrome with celiacomesenteric trunk anomaly. The patient was managed conservatively with close follow-up. Conclusion Nutcracker syndrome associated with celiacomesenteric trunk anomaly is extremely uncommon and is a rare cause of hematuria in children. Whether this abnormal anatomy is the cause of nutcracker syndrome or just an association should be investigated. Moreover, awareness of this anatomical variation may help in planning therapeutic options and reducing the chance of surgical iatrogenic injuries.

Published
2017

215. Telemedicine : Between Reality and Challenges in Jeddah Hospitals

Author

Farah Mamoun Al Khatib, Abeer Abdulrahman J Althbiti, and Nuha Ayman AL-Ghalayini

Subjects
medicine.medical_specialty, Telemedicine, 020205 medical informatics, business.industry, Public health, media_common.quotation_subject, 02 engineering and technology, Telehealth, medicine.disease, Health administration, 03 medical and health sciences, Face-to-face, 0302 clinical medicine, Health care, 0202 electrical engineering, electronic engineering, information engineering, medicine, Optometry, Quality (business), 030212 general & internal medicine, Medical emergency, Human resources, business, media_common
Abstract

Background: Telehealth system is defined as the use of electronic information and telecommunication technologies to support and promote long-distance clinical health care, patient and professional health-related education, public health and health administration. The main aim of this study is to assess difficulties and limitations in hospitals that have healthcare system in Jeddah ,Saudi Arabia from applied new techniques such as Telehealth and if they have tendency to use this technique or not . This study also aims to determine the association between increase in quality of healthcare system and new techniques applied such as Telehealth system by literatures reviews. Methods: A cross-sectional study was conducted in 114 medical providers who worked at hospitals in Jeddah, Saudi Arabia. The medical providers were interviewed using paper-based questionnaire as well as electric-based questionnaire, data collected and analyzed by using SPSS. Results: Interested participants in technology were high by 59%, participants actually interested to implement advanced Telehealth Technologies by percent of 84%, and respectively that factor of lack of awareness were a major factor by 90%, factor of this technique may take a new health care system and it may being a time consuming and take a lot of money and training 71%, this previous percentage and frequency also present factor of resistance in both medical social and community. 63% saw that it is hard to get someone qualified as well as 62% saw that there is a lack of human resources in hospitals and misusing factor took a percent of 50%, some of participants saw that There is no strong need for this technique and he is think it is not important or it is not differ from face to face visit by percent of 40%. Conclusion: There are a high acceptance of new technique in hospitals and regardless of demographic information there is a high interest in technology, we determine most factors that may limit implementation of this technique and these factors may give us a general look about challenges of implementing the other techniques too, if we can determine the problems then we can resolve them to achieve high quality healthcare systems in our hospitals.

Published
2017
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216. The Relationship between War Trauma and Anxiety and Posttraumatic Stress Disorder among Preschool Children in the Gaza Strip = العلاقة بین رض الحرب واضطراب كرب ما بعد الرض والقلق لدى الأطفال ما قبل سن المدرسة في قطاع غزة

Author

Abdelaziz Mousa Thabet and Heba Al Ghalayini

Subjects
medicine.medical_specialty, Gaza strip, 030227 psychiatry, 03 medical and health sciences, Posttraumatic stress, 0302 clinical medicine, medicine, Anxiety, War trauma, medicine.symptom, Psychiatry, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Published
2017
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217. The Changing Landscape for Stroke Prevention in AF

Author

Mercedes Samson, Siegfried Frickel, Hirosi Meno, Niels Gadsbøll, Sébastien Prévôt, Sorin Alexandru Antonescu, Xiaodong Li, Tetsuya Haruna, Zicheng Li, Catarina Fonseca, Ralf Zahn, Shahid Aziz, Takashi Tsutsui, Galal Kerfes, Elisabeth Louise Zeuthen, Lluís Mont, Angelika Tamm, Bogdan Minescu, Eric Lo, Gerardo Ansalone, Malcolm Foster, Tristan Mirault, Nabil Andrawis, Apostolos Katsivas, Imad Kreidieh, Juliano Novaes Cardoso, Margaret Ikpoh, Dimitar Raev, Said Chaaban, Dan Tesloianu, Philippe Loiselet, Joachim Gmehling, Joseph Hakas, Steven Forman, Ernst Günter Vester, Bettina Schmitz, Hassan El-Sayed, Hiroshi Tsutsui, Salvatore Pirelli, Jens Taggeselle, Arnljot Tveit, David Smith, Manuel De Los Rios Ibarra, Rafael Salguero, Jindrich Spinar, Vanja Bašić Kes, Jose Walter Cabrera Honorio, Adrien Salem, Gavino Casu, Jean Michel Quedillac, Ana Fruntelata, Peter Siostrzonek, Dmitry Napalkov, Luthando Adams, Valeria Calvi, Jeff S. Healey, Magnus Forsgren, Larisa Kalinina, Ratika Parkash, P. F.M.M. Bergen van, Carmen Manuela Muresan, H. Gorka, Andreas Mügge, Gustavo Maid, Serge Yvorra, Alexander Paraschos, Bernhard Witzenbichler, Viktor Peršić, Jeong Su Kim, Dong Jin Oh, Yutaka Furukawa, Steve Compton, Ravikiran Korabathina, Tammam Al-Joundi, Muzahir H. Tayebjee, Robert Betzu, David J. Cislowski, Alon Steinberg, Carisi Anne Polanczyk, Sanjiv Petkar, Andy Lam, Mingsheng Wang, Galina Ivanchura, Ruediger Seebass, Thomas Guarnieri, Seth H. Baker, Paula Carvalho, Brian First, Konstantinos Makaritsis, Alex C. Spyropoulos, Mohiburrahman Sirajuddin, Richard Bala, David Goldscher, G. Larsen Kneller, Ki Seok Kim, Sherman Tang, Venkat Iyer, Payman Sattar, Yamile Porro, Gregory Y.H. Lip, Christa Raters, Olivier Gartenlaub, Elizaveta Panchenko, Niccolo' Marcionni, Ole Nyvad, Sibel Zehra Aydin, Kenji Kawajiri, Dipankar Dutta, Gabriel Contreras Buenostro, Shaival Kapadia, Harry J.G.M. Crijns, Miroslav Rubacek, Myriam Brunehaut, Igor Diemberger, Kyle Rickner, Katsumi Tanaka, Moon Hyoung Lee, Pamela Nerheim, Jose Carlos Moura Jorge, Michael Gumbley, Katie Randall, Francesco Melandri, Sunil Chand, Harukazu Iseki, Thalie Traissac, Ningfu Wang, Ghiath Mikdadi, Peter D. Schellinger, Andrew M. Rubin, Conrad Genz, Karl Heinz Seidl, Maurice Pye, Giorgio Annoni, Adalberto Menezes Lorga Filho, William H. Pentz, Lisa Schmitz, Gary Miller, Didier Smadja, Elena Khludeeva, David Hargroves, Hans-Christoph Diener, Tiziano Moccetti, Azlisham Mohd Nor, Kai Koenig, F. A. Rooyer, Kiyoo Mori, Carlos Gonzalez Juanatey, Jan Beyer-Westendorf, Charles Landau, Steven B Eisenberg, Hugh F. McIntyre, Emilio Gonzalez Cocina, Erik May, Gyo-Seung Hwang, Alberto Giniger, Karl-Heinz Kuck, Yan Carlos Duarte Vera, Vladimir Gorbunov, Priya Nair, Shih Ann Chen, Beat J. Meyer, Donghui Zhang, Feng Wang, Richard J.H. Smith, Michele Massimo Gulizia, Darko Pocanic, Abul Azim, Jose Maria Lobos, Patrick Leprince, Peter Vanacker, Marica Bracic Kalan, James Crenshaw, Ewa Nowalany-Kozielska, Ayham Al-Zoebi, Eiji Hishida, Louis Essandoh, Younghoon Kim, Yanmin Yang, Dhiraj Gupta, Fausto J. Pinto, Arnold Pinter, Stanley Koch, Luis Felipe Pezo, Dzifa Wosornu Abban, Martin S. Green, Chrystalenia Kafkala, Zhitao Liu, Jose Luis Llisterri, Su Mei Angela Koh, Lin Chih-Chan, Ruth Davies, Ursula Rauch-Kroehnert, Julio Tallet, Juan Benezet-Mazuecos, Andreas Kastrup, Rohit Malhotra, Serge Timsit, Thierry Frappé, Kostas Oikonomou, Ameer Kabour, Kishor Vora, Douglas Roberts, Carlos Scherr, Pedro Dionísio, Nicoleta Violeta Miu, Eve Gillespie, Petr Povolny, F.R. Grondin, Philippe Lyrer, Raymond Fisher, Philip O'Donnell, Nima Amjadi, Juan Vazquez, Lynn Corbett, Patrick Peters, Jing Zhou, Thomas Kümler, Danny H.K. Wong, Evaldas Giedrimas, William McGarity, Frank L. Silver, Emmanuel Touzé, Ana Leitão, Suk keun Hong, Marwan Salfity, Constantin Militaru, S T Matskeplishvili, Johannes A. Kragten, Sam Henein, Anthony D'Souza, B. J. Krenning, Francesco Chiarella, Rene Casanova, Stephan Willems, Yong Keun Cho, Tae Joon Cha, Stewart Pollock, Rajendra Moodley, Rosa Ysabel Cotrina Pereyra, Volker Laske, Zhanquan Li, Kenneth B. Harris, Johnny Dy, Gabriele Guardigli, Hisham Kashou, Norberto Matadamas Hernandez, Zdravka Poljaković, E. Decoulx, Paul Wakefield, Sung Ho Her, Fatma Qaddoura, Giuseppe Boriani, Younus Ismail, Franz Goss, Shigeru Fujii, J. R. Groot de, Ming Shien Wen, Rui Candeias, Thomas Rebane, Juan Carlos Arias, Robert Jobe, Nicolas Ley, Taishi Sasaoka, Luigi Ria, Jonathan Banayan, Paul McLaughlin, Sergei Zenin, Luis E. Martinez, Thuraia Nageh, Fabrizio Ammirati, M. E.W. Hemels, Yutaka Shimizu, Elina Trendafilova, Maxime Fayard, Randeep Suneja, Attilia Maria Pizzini, Mark B. Abelson, Rabih R. Azar, Jian Zhou, Valerie Bockisch, Martin Koschutnik, James Hitchcock, Vlad Ciobotaru, Didier Irles, Patrik Michel, Witold Streb, John F. Corrigan, Ajit Singh Khaira, Marco Antônio Mota Gomes, Richard Tytus, Christian Hall, Antonius Ziekenhuis, Catherine Mallecourt, David J. Williams, Doo Il Kim, Brian Gordon, Salvatore Novo, Soufian Al Mahameed, Anil Shah, N. Joseph Deumite, Brent T. McLaurin, Ruth H. Strasser, Somnath Kumar, Genshan Ma, Aurel Cracan, Rajiv Mallik, Anthony Vlastaris, Francesco Perticone, Julio Alberto Aguilar Linares, Angel Moya, William Ashcraft, Steven Lupovitch, Renate Weinrich, Ralph F. Bosch, Gerald Ukrainski, Jon Arne Sparby, Norbert Schön, Pierre Jean Scala, Steven E. Hearne, Mark Roman, Ramin Farsad, Werner Rieker, Guillaume Cayla, Ramon Freixa, Hidemitsu Nakagawa, Kunihiro Nishida, Thomas J. Mulhearn, Tak W. Kwan, Jeffrey Shanes, Tiziana Tassinari, Ka Sing Lawrence Wong, Kneale Metcalf, Dominique Lejay, Daniel Savard, Pierre Chevallereau, Gilles O'Hara, Milan Mikus, Hiroshi Fukunaga, Olga Korennova, Xavier Ducrocq, Edvard Berngard, Mario Bo, Hoi Fan Chow, E. Ronner, Yuriy Grinshstein, Amparo Mena, Sidiqullah Rahimi, Axel Brandes, Shigenobu Bando, Freddy Del-Carpio Munoz, Jonathan L. Halperin, Ronald D. Jenkins, Carlos Rodríguez Pascual, Alain Lacroix, Sergio Agosti, Franklin Handel, Aylmer Tang, Nan Jiang, Diana A. Gorog, Dimitrios Stakos, Gerald Greer, Dudley Goulden, Martin Grond, Oran Corey, Stellan Bandh, Efrain Gonzalez, Alexander Klein, Jacques Scemama, Amelie Elsaesser, Nathan Foster, Francesco Fedele, Dinesh Mistry, Alberto Caccavo, Bjørn Bratland, Jean Marc Davy, D. J. Boswijk, Abdullah Al Ali, Muhammad Khalid, Terry McCormack, Clare Seamark, Enrico Passamonti, Zoran Olivari, Simon W Dubrey, Wlodzimierz Musial, Antonio Martín Santana, Jianqiu Liang, Manuel de Mora, Dmitry Dupljakov, Nicholas Jones, Mohamed Alshehri, Paul Charbel, John Bullinga, Petr Polasek, Hossein Almassi, Reza Mehzad, Gamal Hussein, Marcus Wiemer, Ali Sharareh, Alexandra Finsen, David Huckins, Denis Angoulvant, Matthias Leschke, Craig Vogel, Stefan Schuster, Juan E. Mesa, Yong Seog Oh, Axel De La Briolle, Jacek Kowalczyk, Louise Shaw, Eduardo de Teresa, Stefan Naydenov, Hubert Vial, Ian I Joffe, Christoph Kleinschnitz, Takeshi Yamashita, A. Salvioni, Aman M. Shah, Michael Renzi, Claude Brunschwig, Ioannis Styliadis, Ravi Bhagwat, Julian Coronel, Asok Venkataraman, Zayd Eldadah, Dinesh Singal, Byung Chun Jung, Michael Lillestol, Mirza S. Baig, Jose Polo, Ira Dauber, Olga Barbarash, Kristina Zint, Pavel Galin, P. J. A. M. Brouwers, Ki Byeong Nam, Andrey Ezhov, Kevin F. Browne, Iveta Sime, Tetsuo Sakai, Jean Louis Georges, Manish Jain, Alexey Nizov, Jean Dillinger, Arif Elvan, John Barton, Rainer Zimmermann, Junji Kanda, Clare Holmes, Werner Jung, Aurélien Miralles, Tatiana Novikova, Steven Georgeson, Yorihiko Higashino, Akira Yamada, David Sprigings, Haroon Rashid, J. W.M. Eck van, Bernard Erickson, Barry Seidman, Koji Kajiwara, Kannappan Krishnaswamy, Daniel Ferreira, Sébastien Armero, Brian Wong, Dong Gu Shin, Ludovic Chartier, Priit Kampus, Francisco Marín, Rickey Manning, Martin Köhrmann, Edward J. Kosinski, Bengt Johansson, Y. S. Tuininga, Simon Cattan, Sergio Dubner, Imran Dotani, Wenchi Kevin Tsai, Gregorio Sanchez, Edwin Blumberg, Charles Crump, Frank Jäger, Christoforos Olympios, Matthew Hoghton, Xinwen Zhao, Derek Muse, Alexandre Guignier, Toby Black, Yuichiro Takagi, Phil Keeling, Richard A. Bernstein, Omar Elhag, Jean Ernst Poulard, Fernando Gabriel Manzur Jattin, James Hampsey, Shahid Mahmood, Steffen Behrens, Tianlun Yang, Elena Dotcheva, Krishnan Challappa, Nam Ho Kim, Claudio Cavallini, Eric Espaliat, Martin James, June Soo Kim, Marc Roelke, Harold Thomas, Charles A. Shoultz, Rami El Mahmoud, José Francisco Kerr Saraiva, Jürgen vom Dahl, Xuebo Liu, Dong Ju Choi, Sergio Mondillo, Ian Parker, Kazuya Yamamoto, Rafael Martin Suarez, Karla M. Kurrelmeyer, Akber Mohammed, Nikitas Moschos, Benoit Coutu, Georgios Hananis, Hamed M. Zuhairy, Giovanni Baula, Suchdeep Bains, Menno V. Huisman, Heng Jiang, Jaroslaw Sek, Yoto Yotov, Malik Ali, Dalmo Antonio Ribeiro Moreira, Torben Larsen, Raed Osman, Marie Paule Houppe Nousse, Shulin Wu, Arturo Raisaro, Efrain Alonso Gomez Lopez, Violeta Cindea Nica, Eduardo Julián José Roberto Chuquiure Valenzuela, Wladmir Faustino Saporito, Changsheng Ma, Francesco Romeo, Jorge Martínez, M. Shakil Aslam, Kenneth J. Rothman, Kamal Al Ghalayini, Magdy Mikhail, Charles Augenbraun, Andreas Wilke, Peter Goethals, John D. McClure, Humberto Rodriguez Reyes, Peter Schoeniger, Nabil Jarmukli, Elizabeth S. Kaufman, Nathalie Duvilla, Jens Wicke, Kausik Chatterjee, Philippe Audouin, Dragan Kovacic, Xingwei Zhang, Brad Frandsen, Alberto Conti, Francisco Aguilar, Sasalu Deepak, Geir Heggelund, David S. Rosenbaum, Sergey P. Golitsyn, Alessandro Capucci, Rodolfo Sotolongo, Begoña Sevilla, François Poulain, Thomas Ronzière, Naseem Jaffrani, Dominik Michalski, Jose Lopez-Sendon, Silvia Di Legge, Bernard Jouve, Chang Sheng Ma, Robert Parris, Sumeet K. Mainigi, Jing Yao, Lars Udo Krause, Ulrich Tebbe, Quansan Zhang, Mathieu Amelot, Peter Crean, Benzy J. Padanilam, Nicolas Breton, Fernando Tomas Lanas Zanetti, Subhash Banerjee, Andrew I. Cohen, Michel Galinier, Jacek Miarka, Gerian Grönefeld, Vicente Bertomeu, Mariusz Gierba, Danny, Anna Ferrier, Luciano Marcelo Backes, Lianqun Cui, Eun-Seok Shin, Andreas Meinel, Jay Koons, Jen Yuan Kuo, Brett Graham, Antonio Garcia Quintana, Michael Hill, Sylvain Destrac, Janko Szavits-Nossan, Shanglang Cai, Joaquín Osca, Luis Aguinaga, Hemal M. Nayak, Chander Arora, Shinji Tayama, Diana Delić Brkljačić, Tiemin Jiang, Miguel Agustin Reyes Rocha, Ronan Collins, Davide Imberti, Kwang Soo Cha, Matthias Gabelmann, Alfredo Astesiano, Christian Weimar, William Eaves, Tatiana Ionova, Khalid Almuti, Thierry Schaupp, Bernhard Paul Lodde, Darlene Elias, Yuichiro Nakamura, Raed Al-Dallow, Eric Parrens, Weihua Li, Alan Bell, Noah Israel, Nadezda Rozkova, Nediljko Pivac, Nooshin Bazargani, Armando Pineda-Velez, Hyung Wook Park, Amin Karim, Clemens Steinwender, Davor Milicic, Gonzalo Barón, Robert Topkis, Mehrdad Ariani, Craig S. Barr, Paulo Bettencourt, Roberto Zanini, Andrew Moriarty, Pascal Goube, Fausto Rigo, Irene Madariaga, Atsushi Sueyoshi, Małgorzata Lelonek, Kevin R. Wheelan, Richard Huntley, Donald Brautigam, Jacek Gniot, Ido Lori, Dragos Vinereanu, Daniel Lee, Kouki Watanabe, Michael Vargas, Natalya Koziolova, James S. Zebrack, Basel Hanbali, Cesare Greco, José Luis Zamorano, Rajesh Patel, Fernando Carvalho Neuenschwander, Sergio Luiz Zimmermann, Shuiping Zhao, Pedro Adragão, Karl Heinz Schmitz, Abdelfatah Alasfar, Olga Ferreira de Souza, David N. Pham, Mark Dayer, Thomas Davee, Yoshiki Hata, Mika Skeppholm, Martin O'Donnell, David Molony, Joe Hargrove, Hani Sabbour, Pascal Defaye, Jochen Bott, Dora Ines Molina de Salazar, Anthony Clay, Giancarlo Landini, Michael McGuire, Dae Kyeong Kim, A. Shekhar Pandey, Bouziane Benhalima, Serge Cohen, Aamir Cheema, Matthias Claus, Marcus L. Williams, Qiangsun Zheng, Karim Bakhtiar, Hailong Lin, Sergio Berti, David Hartley, Libor Nechvatal, Rami Mihail Chreih, Domingo Pozzer, James Capo, John Floyd, Bhola Rama, Harald Darius, Ioannis Mantas, Pareed Aliyar, Carlos Barrera, Galina Ketova, Mark Chang, Alan J. Bank, José Ferreira Santos, Samir Turk, Lakshmanan Sekaran, Adam Ellery, Aurélie Buhl, Naomasa Miyamoto, Kuo Ho Yeh, Nicolas Mousallem, Hassan Soda, Dimitrios J. Richter, Zhaohui Wu, Tim Edwards, Kai Sukles, Koji Maeno, Huanyi Zhang, Paolo Verdecchia, Alexandros Gkotsis, Joe Pouzar, Philippe Berdagué, Edoardo Gronda, Olesya Rubanenko, Cristian Podoleanu, Mariano Ruiz Borret, Guillermo Llamas Esperon, Iveta Mintale, Hideki Shimomura, Dadong Zhang, Angelo Amato Vicenzo de Paola, Kenneth Butcher, Pascal Tessier, Minang Turakhia, Peter Svensson, Shabbir Reza, Herbert Pardell, Wilfried Lang, Holger Poppert, Alan Ackermann, Olivier Citerne, Emil Hayek, Yang Zheng, Jin bae Kim, Lorenzo Fácila, Tetsuo Hisadome, Li Sun, Panagiotis Vardas, Angel Grande, Piers Clifford, C. Zwaan van der, Nicki Law, Ilsbe Salecker, Steven Isserman, Shozo Tanaka, Dorothee B. Bartels, Yann Hemery, Susanna Cary, Mehiar El-Hamdani, Indira Natarajan, Miney Paquette, C. Wilson Sofley, Charles C. Gornick, Fu-Tien Chiang, Ellen Bøhmer, Hiroki Yamanoue, Toru Nakayama, Chakri Yarlagadda, Ciro Indolfi, Narendra Singh, Juan Carlos Nunez Fragoso, Eisho Kyo, Laurent Deluche, Andreas Götte, Stephen Phlaum, Jong Sung Park, Paresh Mehta, Terrence C. Hack, Fred Cucher, Olivier Dibon, Chia Theng Daniel Oh, Shannon Twiddy, Sean Connors, Edo Bottacchi, Beata Wożakowska-Kapłon, Ronald B. Goldberg, Jordi Bruguera, James J. Kmetzo, Jeanne Wei, John Kazmierski, Pilar Mazón, M Frais, Kazuya Kawai, Dimitrios Alexopoulos, Abayomi Osunkoya, Wanda Sudnik, Ramon Horacio Limon Rodriguez, William J. French, Ira Lieber, Rajesh Aggarwal, Stuart W. Zarich, John A. Puleo, David Cudmore, Jost Henner Wirtz, Ute Altmann, Kyung Tae Jung, Jennifer Litchfield, Jei Keon Chae, Rainer Dziewas, James Neiman, Karin Rybak, Galina Chumakova, Riccardo Pini, Richard Oliver, Benoit Lequeux, Athanasios J. Manolis, Luisa Fonseca, César A. Jardim, Katsuhiro Matsuda, Paul Hermany, Ming Luo, Ronnie Garcia, Oscar Pereira Dutra, John Culp, Amrit Pal Singh Takhar, Victor Howard, Oyidie Igbokidi, Kuo Yang Wang, Britta Goldmann, Thomas Walter, Mohamed K. Al-Obaidi, Antonio Pose, Christine Teutsch, Arthur J. Labovitz, Thomas Folk, Nell Wyatt, A. Huizenga, Benhur Henz, Konstantin Protasov, Petra Maskova, Ioannis Goudevenos, Kier Huehnergarth, Elena Kinova, Georgios Stergiou, Guohai Su, Hüseyin Ince, Chi Hung Huang, Winfried Haerer, Saad Al Ismail, Michael Gabris, Brian Carlson, Feng Liu, Yansheng Li, Luis Gustavo Gomes Ferreira, Radosław Lenarczyk, Ruben Omar Iza Villanueva, Nandkishore Ranadive, Yong Xu, Oscar Saenz Morales, Wayne Turner, Aleksey Khripun, Paul G. Grena, Yusuke Fujino, Abraham Salacata, Aleksandar Knezevic, Fouad Elghelbazouri, Hamid Bayeh, Mikhail Torosoff, Martin Cooper, Alenka Mavri, Marina Freydlin, Vassilios Vassilikos, Naresh Ranjith, Laurent Prunier, E. Hoffer, George Mitchell, Javier León Jiménez, S.S. Kabbani, Waldemar Krysiak, Emmanuel Nsah, John Ip, Charles B. Eaton, Jérome Thevenin, Dimitrios Chrysos, Asaad Bakbak, L. Steven Zukerman, Maria Grazia Bongiorni, Matthias von Mering, Lisa Alderson, Jean Joseph Muller, Yann Jamon, Roger Moore, Harinath Chandrashekar, Athanasios Pras, Venkatesh Nadar, B. J. Berg van den, Tomas Ripoll, Eric Van De Graaff, Patrick Dary, Peter L. Schwimmbeck, James Poock, Robert Schnitzler, Rohit Arora, Vuong DuThinh, Uwe Gremmler, Nuno Raposo, Chirag Sandesara, Ping Yen Bryan Yan, Junya Shite, Andrea Berz, Isabel Egocheaga, Karine Lavandier, Jose M. Teixeira, Ewart Jackson-Voyzey, Mayar Jundi, Ignacio Iglesias, Stephen Bloom, Hans Rickli, Rudolph Evonich, Giulio Molon, Vinay Shah, Salvador Bruno Valdovinos Chavez, Walter Ageno, Mauro Esteves Hernandes, Ali Ghanbasha, Stefan Regner, Luc De Wolf, Abdel El Hallak, Mohammad Shoukfeh, Francesco Musumeci, Pablo Andres Sepulveda Varela, Gershan Davis, Xianyan Jiang, Matthew Ebinger, Xiangdong Xu, Andreas Winkler, T. A. Simmers, Olivier Dascotte, Dominique Magnin, Karen Mahood, Carolina Guevara Caiedo, Zulu Wang, Hung-Fat Tse, John Camm, Didier Cadinot, Javier Aguila Marin, Juan Jose Olalla, Tamara Everington, Sherryn Roth, Feliz Alvaro Medina Palomino, Gregg Coodley, Wenhui Liu, G. Y. H. Lip, Ricky Ganim, Paul Ainsworth, Luiz Eduardo Fonteles Ritt, Yalin Liu, Sung Won Jang, Percy Berrospi, Dhananjai Menzies, Julien Pineau, Robert J. Jeanfreau, Hervé Buathier, John D. Osborne, Ted S. N. Lo, Li Fern Hsu, Xi Su, Beate Wild, Alvaro Rabelo Alves, Tomas Cieza-Lara, Neeraj Prasad, Yoshinori Seko, Jaydutt Patel, Malte Kuniss, Guy Chouinard, Jacek Morka, Frank Rubalcava, Fran Adams, Ignacio Rodriguez Briones, Vivek Sharma, Xinhua Wang, Amir Malik, Walid Amara, Adnan El Jabali, José Arturo Maldonado Villalon, Frederic Georger, Hong Ma, Steffen Schnupp, Nolan Mayer, Adam Sokal, Nasser Abdul, Gérald Phan Cao Phai, Jorge Hugo Blanco Ibaceta, Ramakrishnan Iyer, Yves Cottin, Barry Troyan, Achim Küppers, Anastas Stoikov, Jasjit Walia, Bruce Iteld, Abdul Alawwa, Christos Milonas, Frank Mibach, Mahfouz El Shahawy, H.William Stites, Neerav Shah, Clifford Ehrlich, Zia Ahmad, Furio Colivicchi, and Laszlo Karolyi

Subjects
medicine.medical_specialty, business.industry, Atrial fibrillation, 030204 cardiovascular system & hematology, medicine.disease, Dabigatran, 03 medical and health sciences, 0302 clinical medicine, Stroke prevention, Antithrombotic, Emergency medicine, medicine, In patient, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, Intensive care medicine, Prospective cohort study, business, Stroke, Fibrinolytic agent, medicine.drug
Abstract

Background: GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic t...

Published
2017
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218. Impact de l'alimentation et de l'effet souche sur l'adaptation de Escherichia coli dans son environnement naturel : le tube digestif

Author

Ghalayini, Mohamed, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université Paris-Nord - Paris XIII, and Olivier Tenaillon

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Groupe phylogénétique, Phylogenetic group, Escherichia coli, Adaptation
Abstract

Escherichia coli is a commensal bacteria of the digestive tract. Under certain strain andhost conditions, it may become a serious intestinal or extra-intestinal pathogen responsible fora significant morbidity and mortality. The E. coli species has a clonal structure within whichphylogenetic groups can be distinguished. Interestingly this structure is partially predictive ofvirulence. In particular, phylogenetic group B2, is composed of strains often isolated in extradigestive disease but are also good commensals. Indeed, disturbingly, the prevalence of thisgroup is increasing in the digestive tract of individuals of industrialized countries. This suggestsa potential coupling between factors working at the level of human populations such as foodand the genetic background of the bacterial strain. Several in vivo evolution experiments of E.coli in the digestive tract of mice have already been conducted and allowed to show a strongadaptation particularly related to energy resources and sugar metabolism. These studies,however, suffered from several limitations such as the use of a laboratory strain, in a non-naturalenvironment and subject to a single diet. The objective of my thesis was to study the adaptationof natural isolates of E. coli in digestive tract. This study was carried out at several levels: bothin natura, but also in vivo depending on the genetic background of the strains and host diet.First, we had the opportunity to follow the adaptation in natura of a dominant ED1a E.coli isolate in the digestive tract of an individual living in the Paris region and without anyhealth problem. We observed that E. coli ED1a, belonging to phylogenetic group B2, evolvedneutrally in the digestive tract. Subsequently, in vivo long-term experiment (over a year) mousemodel was used to study the impact of diet and genetic background of strain in the adaptationof E. coli to the digestive tract. The purpose of the first experiment was to study the adaptationof a natural isolate of E. coli, strain 536 (belonging to the phylogenetic group B2 and initiallyisolated in urinary tract infection), in a mouse digestive tract as close as possible to the naturalconditions (using the principle of transmission of digestive microbiota from mother tooffspring) and two diets: standard or high in fat and sugar. We were able to demonstrate aconstitutive activation of the lactose operon occurring during the lactation period of offspringand then a neutral evolution regardless of the diet. The purpose of the second mice experimentwas to study the impact of the host diet on the evolution of two natural isolates of E. coli, strain536 and strain HS, the latter belonging to the phylogenetic group A, a group known to be mostlycommensal in human. We used this time mice treated with streptomycin. We were able todistinguish two adaptation profiles according to the strain and diet. The intensity of adaptationdepended on the strain and probably its genetic background, and the target of adaptationdepended on the diet. More precisely, the targets of adaptation were mainly associated with thesugar metabolism.These studies represent an important advance in the understanding of the selectivepressures acting on E. coli in vivo.; Escherichia coli est une bactérie commensale du tube digestif qui, dans certainesconditions dépendantes de la souche et de l’hôte, peut devenir un redoutable pathogèneintestinal ou extra-intestinal responsable d’une morbi-mortalité significative. L’espèce E. colipossède une structure clonale au sein de laquelle on peut différencier des groupesphylogénétiques. De façon intéressante cette structure est partiellement prédictive de lavirulence. En particulier, le groupe phylogénétique B2, est composé de souches souvent isoléesde pathologies extra-intestinales mais qui sont aussi de bonnes commensales. En effet, de façoninquiétante, la prévalence de ce groupe augmente dans le tube digestif des individus des paysindustrialisés. Cela suggère un potentiel couplage entre des facteurs œuvrant à l’échelle despopulations humaines comme l’alimentation et le fond génétique de la souche bactérienne.Plusieurs expériences d’évolution in vivo d’E. coli dans le tube digestif de souris ont déjà étémenées et ont permis de montrer une forte adaptation notamment liée aux ressourcesénergétiques et au métabolisme de sucres. Ces études souffraient cependant de plusieurslimitations comme l’utilisation d’une souche de laboratoire, d’un milieu non naturel ou encored’un seul régime alimentaire. L’objectif de ma thèse a donc été d’étudier les modes d’adaptationd’isolats naturels de E. coli dans le tube digestif. Cette étude a été effectuée à plusieurs niveaux:à la fois in natura, mais aussi in vivo en fonction du fond génétique des souches et del’alimentation de l’hôte.Dans un premier temps, nous avons eu l’opportunité de suivre l’adaptation in naturad’un isolat de E. coli ED1a dominant dans le tube digestif d’un individu vivant en régionparisienne et sans problème de santé. Nous avons pu observer que E. coli ED1a, appartenant augroupe phylogénétique B2, évoluait de façon neutre dans le tube digestif. Le recours auxexpérimentations in vivo sur modèle murin au long court (plus d’un an) s’est avéré nécessairepour étudier l’impact de l’alimentation et du fond génétique de la souche dans l’adaptation deE. coli dans le tube digestif. Le propos de la première expérimentation était d’étudierl’adaptation d’un isolat naturel de E. coli 536 (appartenant au groupe phylogénétique B2 etinitialement issu d’infection urinaire), dans un tube digestif de souris se rapprochant le pluspossible des conditions naturelles (en utilisant le principe de transmission du microbiote digestifde la mère à la progéniture) et soumises à deux régimes alimentaires : standard ou riche en graset en sucre. Nous avons pu mettre en évidence une activation constitutive de l’opéron lactosesurvenant lors de la période d’allaitement des progénitures pour ensuite évoluer de manièreneutre quelque soit le régime alimentaire. Le propos de la deuxième expérimentation étaitd’étudier l’impact du fond génétique de la souche combinée à l’alimentation en étudiantl’évolution de deux isolats naturels de E. coli 536 et HS (appartenant au groupe phylogénétiqueA et issu d’une situation commensale chez un humain) dans le tube digestif de souris traitées àla streptomycine. Nous avons pu distinguer deux profils d’adaptation en fonction de la soucheet de l’alimentation. Il semblerait que l’intensité de l’adaptation dépende préférentiellement dela souche et probablement de son fond génétique, et que les cibles de l’adaptation dépendentplutôt du régime alimentaire. Plus précisément, ces cibles semblent principalement êtreassociées au métabolisme de sucres. Ces études constituent un progrès important dans lacompréhension des pressions sélectives agissant sur E. coli in vivo.

Published
2019

220. Modeling and Forecasting the Infrastructure Investments Needs in Lebanon

Author

Latife Ghalayini and Fabienne Saade

Subjects
Lebanese Infrastructure, Education, Investment Needs, Government Expenditures, Dynamic OLS, Solid Waste
Abstract

The aim of this paper is to model and forecast the infrastructure investment needs in Lebanon. It divides the Lebanese infrastructure into ten main sectors, and it represents an analysis of each sector. The article collects data of the government expenditures on projects for each sector from the Lebanese council of development and reconstruction. The expenditure on each sector represents a different impact on the Lebanese growth and the Gross Domestic Product, the article analyses the impact in an assessment approach. Findings emphasis the importance of social infrastructure in promoting growth, especially Education sector. Furthermore, findings stress the high volume of expenditure on waste water and solid waste management sector. The article proceeds by modeling the infrastructure investment need using Dynamic OLS equilibrium. The study encloses ten Dynamic OLS models, one for each sector, having the investment needs as the dependent variable, and as independent variables the Lebanese Gross Domestic Product and the Lebanese population. Eventually, the paper forecasts the Lebanese infrastructure investment needs for each sector until the year 2025. Results emphasis the unfair low expenditure on Education and other social infrastructures, and the high expenditures on inefficient sectors such as the waste water and solid waste sector, and the electricity sector. The study eventually recommends a better distribution of infrastructure investments within the Lebanese expenditures.

Published
2019

221. Preparation and printability of ultrashort self-assembling peptide nanoparticles

Author

Hepi Hari Susapto, Kowther Kahin, Charlotte A. E. Hauser, Sophie Hall, and Sarah Ghalayini

Subjects
chemistry.chemical_classification, Ultrashort peptides, Biodistribution, Chemistry, Materials Science (miscellaneous), Microfluidics, education, technology, industry, and agriculture, Nanoparticle, Peptide, Nanotechnology, Self-assembly, Industrial and Manufacturing Engineering, Biomaterials, Drug delivery, Self-healing hydrogels, Nanoparticles, Biotechnology, Self-assembling peptide, Research Article
Abstract

Nanoparticles (NPs) have left their mark on the field of bioengineering. Fabricated from metallic, magnetic, and metal oxide materials, their applications include drug delivery, bioimaging, and cell labeling. However, as they enter the body, the question remains – where do they go after fulfilling their designated function? As most materials used to produce NPs are not naturally found in the body, they are not biodegradable and may accumulate overtime. There is a lack of comprehensive, long-term studies assessing the biodistribution of non-biodegradable NPs for even the most widely studied NPs. There is a clear need for NPs produced from natural materials capable of degradation in vivo. As peptides exist naturally within the human body, their non-toxic and biocompatible nature comes as no surprise. Ultrashort peptides are aliphatic peptides designed with three to seven amino acids capable of self-assembling into helical fibers within macromolecular structures. Using a microfluidics flow-focusing approach, we produced different peptide-based NPs that were then three-dimensional (3D) printed with our novel printer setup. Herein, we describe the preparation method of NPs from ultrashort self-assembling peptides and their morphology in both manual and 3D-printed hydrogels, thus suggesting that peptide NPs are capable of withstanding the stresses involved in the printing process

Published
2019

222. WITHDRAWN: Saudi Heart Association (SHA) Guidelines for the Management of Heart Failure

Author

Abdelfatah Elasfar, Ammar Chaudhary, Shukri AlSaif, Adel Tash, Kamal W Ai-Ghalayini, Fakhr AlAyoubi, Maryam Al Qaseer, Yahya Al Hebaishi, Mouaz H. Al-Mallah, Fahad Al Ghofaili, Abdulrazaq Al-Jazairi, Waleed AlHabeeb, and Ali Almasood

Subjects
medicine.medical_specialty, business.industry, Association (object-oriented programming), Emergency medicine, Management of heart failure, medicine, business
Published
2019
Full Text
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223. Long-term evolution of the natural isolate of Escherichia coli 536 in the mouse gut colonized after maternal transmission reveals convergence in the constitutive expression of the lactose operon

Author

Olivier Tenaillon, Ouassila Zatout, Lucie Bourguignon, Sara Dion, Mélanie Magnan, Mathilde Lescat, and Mohamed Ghalayini

Subjects
0106 biological sciences, 0301 basic medicine, lac operon, Lac repressor, medicine.disease_cause, Diet, High-Fat, 010603 evolutionary biology, 01 natural sciences, Genome, 03 medical and health sciences, chemistry.chemical_compound, Mice, Gene expression, Genetics, medicine, Escherichia coli, Animals, Lactose, Axenic, Ecology, Evolution, Behavior and Systematics, 2. Zero hunger, Experimental evolution, biology, Genetic Drift, biology.organism_classification, Adaptation, Physiological, Biological Evolution, Infectious Disease Transmission, Vertical, Gastrointestinal Tract, 030104 developmental biology, chemistry, Lac Operon, Mutation, Female, Genome, Bacterial
Abstract

In vitro experimental evolution has taught us many lessons on the molecular bases of adaptation. To move towards more natural settings, evolution in the mice gut has been successfully performed. Yet, these experiments suffered from the use of laboratory strains as well as the use of axenic or streptomycin-treated mice to maintain the inoculated strains. To circumvent these limitations, we conducted a one-year experimental evolution in vivo using a natural isolate of E. coli, strain 536, in conditions mimicking as much as possible natural environment with mother-to-offspring microbiota transmission. Mice were then distributed in 24 independent cages and separated into two different diets: a regular one (chow diet, CD) and high-fat and high-sugar one (Western Diet, WD). Genome sequences revealed an early and rapid selection during the breastfeeding period that selected the constitutive expression of the well-characterized lactose operon. E. coli was lost significantly more in CD than WD; however, we could not detect any genomic signature of selection, nor any diet specificities during the later part of the experiments. The apparently neutral evolution presumably due to low population size maintained nevertheless at high frequency the early selected mutations affecting lactose regulation. The rapid loss of lactose operon regulation challenges the idea that plastic gene expression is both optimal and stable in the wild.

Published
2019

224. Efficiency of Lebanese and Arab Gulf Financial Markets

Author

Pr. Latifa Ghalayini and Alkees, Sally

Subjects
Weak Form Market Efficiency, Volatility, Market Capitalization, Traded Volume, Unit Root Test, Random Walk Theory
Abstract

Various studies have been made to test the efficiency of market in Lebanon and Arab Gulf States (AGS) theoretically and empirically, focusing mainly on building a model using the conventional finance. The purpose of this paper is to test the efficiency of AGS financial markets as well as the Lebanese one based on stationary method; furthermore it explores the reasons behind the non-efficiency in case it exists. However, to realize this objective ,this paper overviews the different methods behind testing efficiency in order to choose and use the most common one ,furthermore it studies also the Volatility using ARCH and GARCH and the Financial Characteristics behind each market, which leads to either enhance or reduce market efficiency so far. Findings prove that Lebanese, Abu Dhabi, Qatar, and Kuwait markets tend to be efficient in its weak form whereas Dubai, Saudi Arabia and Amman markets are non-efficient based on the average monthly data series and financial characteristics of the market over a specific period of time.

Published
2019
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225. Estimating the Value of the Lebanese Oil Resources Modeling and Forecasting Oil Price

Author

Latife Ghalayini and Fabianne Saade

Subjects
Oil reserves, Value (economics), Economics, Dynamic OLS, Future oil markets, Gold price, Lebanese oil resources, Open interest, Spot oil price, Oil price, Agricultural economics
Abstract

The aim of this paper is to estimate the value of the Lebanese oil resources. It presents an overview of the natural resources within the Lebanese territories and economic zone. Furthermore, it analyses the oil spot price characteristics and volatility. It studies the oil future market while exploring the relation between speculation and spot oil price in the short run. Findings prove that in the short run, changes in oil inventories do not Granger cause changes in oil price, neither does the change in future prices. However, outcomes show that in the short run, the change in gold price granger causes the oil spot price. Additionally, in the aim of forecasting accurate oil price, the paper builds a Dynamic OLS equilibrium. The model includes the oil demand, the oil supply, the oil inventories, the USD/SDR exchange rate, the Gold price, and the open interest contracts in futures market as speculation effect. Eventually, with an estimate of the volume of the resources and the price forecasts until 2025, the paper forecasts the value of the Lebanese resources.

Published
2019
Full Text
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226. Impact of diet and effect of strain on the adaptation of Escherichia coli in its natural environment : the digestive tract

Author

Ghalayini, Mohamed, STAR, ABES, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Université Paris-Nord - Paris XIII, and Olivier Tenaillon

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Groupe phylogénétique, Phylogenetic group, Escherichia coli, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Adaptation
Abstract

Escherichia coli is a commensal bacteria of the digestive tract. Under certain strain andhost conditions, it may become a serious intestinal or extra-intestinal pathogen responsible fora significant morbidity and mortality. The E. coli species has a clonal structure within whichphylogenetic groups can be distinguished. Interestingly this structure is partially predictive ofvirulence. In particular, phylogenetic group B2, is composed of strains often isolated in extradigestive disease but are also good commensals. Indeed, disturbingly, the prevalence of thisgroup is increasing in the digestive tract of individuals of industrialized countries. This suggestsa potential coupling between factors working at the level of human populations such as foodand the genetic background of the bacterial strain. Several in vivo evolution experiments of E.coli in the digestive tract of mice have already been conducted and allowed to show a strongadaptation particularly related to energy resources and sugar metabolism. These studies,however, suffered from several limitations such as the use of a laboratory strain, in a non-naturalenvironment and subject to a single diet. The objective of my thesis was to study the adaptationof natural isolates of E. coli in digestive tract. This study was carried out at several levels: bothin natura, but also in vivo depending on the genetic background of the strains and host diet.First, we had the opportunity to follow the adaptation in natura of a dominant ED1a E.coli isolate in the digestive tract of an individual living in the Paris region and without anyhealth problem. We observed that E. coli ED1a, belonging to phylogenetic group B2, evolvedneutrally in the digestive tract. Subsequently, in vivo long-term experiment (over a year) mousemodel was used to study the impact of diet and genetic background of strain in the adaptationof E. coli to the digestive tract. The purpose of the first experiment was to study the adaptationof a natural isolate of E. coli, strain 536 (belonging to the phylogenetic group B2 and initiallyisolated in urinary tract infection), in a mouse digestive tract as close as possible to the naturalconditions (using the principle of transmission of digestive microbiota from mother tooffspring) and two diets: standard or high in fat and sugar. We were able to demonstrate aconstitutive activation of the lactose operon occurring during the lactation period of offspringand then a neutral evolution regardless of the diet. The purpose of the second mice experimentwas to study the impact of the host diet on the evolution of two natural isolates of E. coli, strain536 and strain HS, the latter belonging to the phylogenetic group A, a group known to be mostlycommensal in human. We used this time mice treated with streptomycin. We were able todistinguish two adaptation profiles according to the strain and diet. The intensity of adaptationdepended on the strain and probably its genetic background, and the target of adaptationdepended on the diet. More precisely, the targets of adaptation were mainly associated with thesugar metabolism.These studies represent an important advance in the understanding of the selectivepressures acting on E. coli in vivo., Escherichia coli est une bactérie commensale du tube digestif qui, dans certainesconditions dépendantes de la souche et de l’hôte, peut devenir un redoutable pathogèneintestinal ou extra-intestinal responsable d’une morbi-mortalité significative. L’espèce E. colipossède une structure clonale au sein de laquelle on peut différencier des groupesphylogénétiques. De façon intéressante cette structure est partiellement prédictive de lavirulence. En particulier, le groupe phylogénétique B2, est composé de souches souvent isoléesde pathologies extra-intestinales mais qui sont aussi de bonnes commensales. En effet, de façoninquiétante, la prévalence de ce groupe augmente dans le tube digestif des individus des paysindustrialisés. Cela suggère un potentiel couplage entre des facteurs œuvrant à l’échelle despopulations humaines comme l’alimentation et le fond génétique de la souche bactérienne.Plusieurs expériences d’évolution in vivo d’E. coli dans le tube digestif de souris ont déjà étémenées et ont permis de montrer une forte adaptation notamment liée aux ressourcesénergétiques et au métabolisme de sucres. Ces études souffraient cependant de plusieurslimitations comme l’utilisation d’une souche de laboratoire, d’un milieu non naturel ou encored’un seul régime alimentaire. L’objectif de ma thèse a donc été d’étudier les modes d’adaptationd’isolats naturels de E. coli dans le tube digestif. Cette étude a été effectuée à plusieurs niveaux:à la fois in natura, mais aussi in vivo en fonction du fond génétique des souches et del’alimentation de l’hôte.Dans un premier temps, nous avons eu l’opportunité de suivre l’adaptation in naturad’un isolat de E. coli ED1a dominant dans le tube digestif d’un individu vivant en régionparisienne et sans problème de santé. Nous avons pu observer que E. coli ED1a, appartenant augroupe phylogénétique B2, évoluait de façon neutre dans le tube digestif. Le recours auxexpérimentations in vivo sur modèle murin au long court (plus d’un an) s’est avéré nécessairepour étudier l’impact de l’alimentation et du fond génétique de la souche dans l’adaptation deE. coli dans le tube digestif. Le propos de la première expérimentation était d’étudierl’adaptation d’un isolat naturel de E. coli 536 (appartenant au groupe phylogénétique B2 etinitialement issu d’infection urinaire), dans un tube digestif de souris se rapprochant le pluspossible des conditions naturelles (en utilisant le principe de transmission du microbiote digestifde la mère à la progéniture) et soumises à deux régimes alimentaires : standard ou riche en graset en sucre. Nous avons pu mettre en évidence une activation constitutive de l’opéron lactosesurvenant lors de la période d’allaitement des progénitures pour ensuite évoluer de manièreneutre quelque soit le régime alimentaire. Le propos de la deuxième expérimentation étaitd’étudier l’impact du fond génétique de la souche combinée à l’alimentation en étudiantl’évolution de deux isolats naturels de E. coli 536 et HS (appartenant au groupe phylogénétiqueA et issu d’une situation commensale chez un humain) dans le tube digestif de souris traitées àla streptomycine. Nous avons pu distinguer deux profils d’adaptation en fonction de la soucheet de l’alimentation. Il semblerait que l’intensité de l’adaptation dépende préférentiellement dela souche et probablement de son fond génétique, et que les cibles de l’adaptation dépendentplutôt du régime alimentaire. Plus précisément, ces cibles semblent principalement êtreassociées au métabolisme de sucres. Ces études constituent un progrès important dans lacompréhension des pressions sélectives agissant sur E. coli in vivo.

Published
2019

231. The Book of Cairo: A City in Short Fiction

Author

Raph Cormack editor translator, Mohamed Salah al-Azab writer, Adam Talib translator, Mohammed Kheir writer, Kareem James Abu-Zeid translator, Hatem Hafez writer, Raphael Cohen writer, Hend Ja'far writer, Basma Ghalayini translator, Hassan Abdel Meguid writer, Thoraya El-Rayyes translator, Nahla Karam writer, Andrew Leber translator, Eman Abdelrahim writer, Ruth Ahmedzai Kemp translator, Ahmed Naji writer, Elisabeth Jaquette translator, Nael Eltoukhy writer, Areej Gamal writer, Yasmine Seale translator, Raph Cormack editor translator, Mohamed Salah al-Azab writer, Adam Talib translator, Mohammed Kheir writer, Kareem James Abu-Zeid translator, Hatem Hafez writer, Raphael Cohen writer, Hend Ja'far writer, Basma Ghalayini translator, Hassan Abdel Meguid writer, Thoraya El-Rayyes translator, Nahla Karam writer, Andrew Leber translator, Eman Abdelrahim writer, Ruth Ahmedzai Kemp translator, Ahmed Naji writer, Elisabeth Jaquette translator, Nael Eltoukhy writer, Areej Gamal writer, and Yasmine Seale translator

Published
2019

232. Palestine +100: Stories from a Century after the Nakba

Author

Basma Ghalayini editor, Saleem Haddad writer, Selma Dabbagh writer, Majd Kayyal writer, Thoraya El-Rayyes translator, Anwar Hamed writer, Andrew Leber translator, Emad El-Din Aysha writer, Abdalmuti Maqboul writer, Yasmine Seale translator, Tasnim Abutabikh writer, Ahmed Masoud writer, Samir El-Youssef writer, Raph Cormack translator, Rawan Yaghi writer, Talal Abu Shawish writer, Mohamed Ghalaieny translator, Mazen Maarouf writer, Jonathan Wright translator, Basma Ghalayini editor, Saleem Haddad writer, Selma Dabbagh writer, Majd Kayyal writer, Thoraya El-Rayyes translator, Anwar Hamed writer, Andrew Leber translator, Emad El-Din Aysha writer, Abdalmuti Maqboul writer, Yasmine Seale translator, Tasnim Abutabikh writer, Ahmed Masoud writer, Samir El-Youssef writer, Raph Cormack translator, Rawan Yaghi writer, Talal Abu Shawish writer, Mohamed Ghalaieny translator, Mazen Maarouf writer, and Jonathan Wright translator

Published
2019

234. The Impact of Behavioral Finance on Lebanese Investors’ Decision Making

Author

Pr Latifa Ghalayini and Sally Ziad Alkees

Subjects
Actuarial science, Prospect theory, Psychological Theory, Judgement, Regret, Decision-making, Heuristics, Psychology, Behavioral economics, Structural equation modeling
Abstract

The inability of the traditional expected utility maximization of rational investors (within the efficient markets Framework) to explain many empirical patterns; was the main stimulus beyond the appearance for another track to resolve and analyze this inconsistency; through combining behavioral and cognitive psychological theory together where Behavioral Finance is known mainly as the irrational part that deals with investors’ Sentimental side. Furthermore it can be agreed on that behavioral finance is considered as “Subjective judgement” where ideas and decisions cannot be transmitted to other’s knowledge, as each one acts from his own point of interest; unlike conventional finance paradigm. Therefore, this paper seeks to determine the main behavioral errors or biases that are faced mainly by the Lebanese individual investor during decision making process. Results obtained by analyzing 211 questionnaires through SPSS software to develop a Structural equation model. Findings prove that Over Confidence and regret aversion are the main behavioral biases that control the Lebanese individual investors’ decision making.

Published
2021
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236. The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author

Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H. -C., Dubner, S. J., Halperin, J. L., C. S., Ma, Zint, K., Elsaesser, A., Bartels, D. B., Lip, G. Y. H., Abban, D., Abdul, N., Abelson, M., Ackermann, A., Adams, F., Adams, L., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Marin, J. A., Aguilar, F., Aguilar Linares, J. A., Aguinaga, L., Ahmad, Z., Ainsworth, P., Al Ghalayini, K., Al Ismail, S., Alasfar, A., Alawwa, A., Al-Dallow, R., Alderson, L., Alexopoulos, D., Ali, A., Ali, M., Aliyar, P., Al-Joundi, T., Al Mahameed, S., Almassi, H., Almuti, K., Al-Obaidi, M., Alshehri, M., Altmann, U., Alves, A. R., Al-Zoebi, A., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrawis, N., Angoulvant, D., Annoni, G., Ansalone, G., Antonescu, S. A., Ariani, M., Arias, J. C., Armero, S., Arora, R., Arora, C., Ashcraft, W., Aslam, M. S., Astesiano, A., Audouin, P., Augenbraun, C., Aydin, S., Azar, R., Azim, A., Aziz, S., Backes, L. M., Baig, M., Bains, S., Bakbak, A., Baker, S., Bakhtiar, K., Bala, R., Banayan, J., Bandh, S., Bando, S., Banerjee, S., Bank, A., Barbarash, O., Baron, G., Barr, C., Barrera, C., Barton, J., Kes, V. B., Baula, G., Bayeh, H., Bazargani, N., Behrens, S., Bell, A., Benezet-Mazuecos, J., Benhalima, B., Berdague, P., Berg van den, B. J., Bergen van, P. F. M. M., Berngard, E., Bernstein, R., Berrospi, P., Berti, S., Bertomeu, V., Berz, A., Bettencourt, P., Betzu, R., Beyer-Westendorf, J., Bhagwat, R., Black, T., Blanco Ibaceta, J. H., Bloom, S., Blumberg, E., Bo, M., Bockisch, V., Bohmer, E., Bongiorni, M. G., Boriani, G., Bosch, R., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Brandes, A., Bratland, B., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Bruguera, J., Brunehaut, M., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Butcher, K., Cabrera Honorio, J. W., Caccavo, A., Cadinot, D., Cai, S., Calvi, V., Camm, J., Candeias, R., Capo, J., Capucci, A., Cardoso, J. N., Duarte Vera, Y. C., Carlson, B., Carvalho, P., Cary, S., Casanova, R., Casu, G., Cattan, S., Cavallini, C., Cayla, G., Cha, T. J., Cha, K. S., Chaaban, S., Chae, J. K., Challappa, K., Chand, S., Chandrashekar, H., Chang, M., Charbel, P., Chartier, L., Chatterjee, K., Cheema, A., Chen, S. -A., Chevallereau, P., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, D. J., Chouinard, G., Danny, Chow, H. F., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Cieza-Lara, T., Nica, V. C., Ciobotaru, V., Cislowski, D., Citerne, O., Claus, M., Clay, A., Clifford, P., Cohen, S., Cohen, A., Colivicchi, F., Collins, R., Compton, S., Connors, S., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Corbett, L., Corey, O., Coronel, J., Corrigan, J., Cotrina Pereyra, R. Y., Cottin, Y., Coutu, B., Cracan, A., Crean, P., Crenshaw, J., Crijns, H. J. G. M., Crump, C., Cucher, F., Cudmore, D., Cui, L., Culp, J., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davee, T., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De La Briolle, A., de Mora, M., De Teresa, E., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deluche, L., Destrac, S., Deumite, N. J., Di Legge, S., Dibon, O., Diemberger, I., Dillinger, J., Dionisio, P., Naydenov, S., Dotani, I., Dotcheva, E., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duthinh, V., Dutra, O. P., Dutta, D., Duvilla, N., Dy, J., Dziewas, R., Eaton, C., Eaves, W., Ebinger, M., Eck van, J. W. 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Goethals, P, Goldberg, R, Goldmann, B, Goldscher, D, Golitsyn, S, Gomez Lopez, E, Gomez Mesa, J, Gonzalez, E, Cocina, E, Juanatey, C, Gorbunov, V, Gordon, B, Gorka, H, Gornick, C, Gorog, D, Goss, F, Götte, A, Goube, P, Goudevenos, I, Goulden, D, Graham, B, Grande, A, Greco, C, Green, M, Greer, G, Gremmler, U, Grena, P, Grinshstein, Y, Grond, M, Gronda, E, Grondin, F, Grönefeld, G, Groot de, J, Guardigli, G, Guarnieri, T, Caiedo, C, Guignier, A, Gulizia, M, Gumbley, M, Gupta, D, Hack, T, Haerer, W, Hakas, J, Hall, C, Hampsey, J, Hananis, G, Hanbali, B, Handel, F, Hargrove, J, Hargroves, D, Harris, K, Hartley, D, Haruna, T, Hata, Y, Hayek, E, Healey, J, Hearne, S, Heggelund, G, Hemels, M, Hemery, Y, Henein, S, Henz, B, Her, S, Hermany, P, Hernandes, M, Higashino, Y, Hill, M, Hisadome, T, Hishida, E, Hitchcock, J, Hoffer, E, Hoghton, M, Holmes, C, Hong, S, Houppe Nousse, M, Howard, V, Hsu, L, Huang, C, Huckins, D, Huehnergarth, K, Huizenga, A, Huntley, R, Hussein, G, Hwang, G, Igbokidi, O, Iglesias, I, Ikpoh, M, Imberti, D, Ince, H, Indolfi, C, Ionova, T, Ip, J, Irles, D, Iseki, H, Ismail, Y, Israel, N, Isserman, S, Iteld, B, Ivanchura, G, Iyer, R, Iyer, V, Iza Villanueva, R, Jackson Voyzey, E, Jaffrani, N, Jäger, F, Jain, M, James, M, Jamon, Y, Jang, S, Pereira Jardim, C, Jarmukli, N, Jeanfreau, R, Jenkins, R, Jiang, X, Jiang, H, Jiang, T, Jiang, N, Jimenez, J, Jobe, R, Joffe, I, Johansson, B, Jones, N, Moura Jorge, J, Jouve, B, Jundi, M, Jung, W, Jung, B, Jung, K, Kabbani, S, Kabour, A, Kafkala, C, Kajiwara, K, Kalinina, L, Kampus, P, Kanda, J, Kapadia, S, Karim, A, Karolyi, L, Kashou, H, Kastrup, A, Katsivas, A, Kaufman, E, Kawai, K, Kawajiri, K, Kazmierski, J, Keeling, P, Kerfes, G, Kerr Saraiva, J, Ketova, G, Khaira, A, Khalid, M, Khludeeva, E, Khripun, A, Kim, D, Kim, N, Kim, K, Kim, Y, Kim, J, Kinova, E, Klein, A, Kleinschnitz, C, Kmetzo, J, Kneller, G, Knezevic, A, Koch, S, Koenig, K, Angela Koh, S, Köhrmann, M, Koons, J, Korabathina, R, Korennova, O, Koschutnik, M, Kosinski, E, Kovacic, D, Kowalczyk, J, Koziolova, N, Kragten, J, Krause, L, Kreidieh, I, Krenning, B, Krishnaswamy, K, Krysiak, W, Kuck, K, Kumar, S, Kümler, T, Kuniss, M, Kuo, J, Küppers, A, Kurrelmeyer, K, Kwan, T, Kyo, E, Labovitz, A, Lacroix, A, Lam, A, Lanas Zanetti, F, Landau, C, Landini, G, Lang, W, Larsen, T, Laske, V, Lavandier, K, Law, N, Lee, M, Lee, D, Leitão, A, Lejay, D, Lelonek, M, Lenarczyk, R, Leprince, P, Lequeux, B, Leschke, M, Ley, N, Li, Z, Li, Y, Li, X, Li, W, Liang, J, Lieber, I, Lillestol, M, Limon Rodriguez, R, Lin, H, Litchfield, J, Liu, Z, Liu, X, Liu, Y, Liu, F, Liu, W, Llamas Esperon, G, Llisterri, J, Lo, T, Lo, E, Lobos, J, Lodde, B, Loiselet, P, López Sendón, J, Lorga Filho, A, Lori, I, Luo, M, Lupovitch, S, Lyrer, P, Zuhairy, H, Ma, G, Ma, H, Madariaga, I, Maeno, K, Magnin, D, Mahmood, S, Mahood, K, Maid, G, Mainigi, S, Makaritsis, K, Maldonado Villalon, J, Malhotra, R, Malik, A, Mallecourt, C, Mallik, R, Manning, R, Manolis, A, Mantas, I, Manzur Jattin, F, Marcionni, N, Marín, F, Santana, A, Martinez, J, Martinez, L, Maskova, P, Hernández, N, Matskeplishvili, S, Matsuda, K, Mavri, A, May, E, Mayer, N, Mazon, P, Mcclure, J, Mccormack, T, Mcgarity, W, Mcguire, M, Mcintyre, H, Mclaughlin, P, Mclaurin, B, Medina Palomino, F, Mehta, P, Mehzad, R, Meinel, A, Melandri, F, Mena, A, Meno, H, Menzies, D, Metcalf, K, Meyer, B, Miarka, J, Mibach, F, Michalski, D, Michel, P, Chreih, R, Mikdadi, G, Mikhail, M, Mikus, M, Milicic, D, Militaru, C, Miller, G, Milonas, C, Minescu, B, Mintale, I, Miralles, A, Mirault, T, Mistry, D, Mitchell, G, Miu, N, Miyamoto, N, Moccetti, T, Mohammed, A, Nor, A, Molina de Salazar, D, Molon, G, Molony, D, Mondillo, S, Mont, L, Moodley, R, Moore, R, Ribeiro Moreira, D, Mori, K, Moriarty, A, Morka, J, Moschos, N, Mota Gomes, M, Mousallem, N, Moya, A, Mügge, A, Mulhearn, T, Muller, J, Muresan, C, Muse, D, Musial, W, Musumeci, F, Nadar, V, Nageh, T, Nair, P, Nakagawa, H, Nakamura, Y, Nakayama, T, Nam, K, Napalkov, D, Natarajan, I, Nayak, H, Nechvatal, L, Neiman, J, Nerheim, P, Neuenschwander, F, Nishida, K, Nizov, A, Novikova, T, Novo, S, Nowalany Kozielska, E, Nsah, E, Nunez Fragoso, J, Nyvad, O, de Los Rios Ibarra, M, O'Donnell, M, O'Donnell, P, Oh, D, Oh, Y, Daniel Oh, C, O'Hara, G, Oikonomou, K, Olalla, J, Olivari, Z, Oliver, R, Olympios, C, Osborne, J, Osca, J, Osman, R, Osunkoya, A, Padanilam, B, Panchenko, E, Pandey, A, Vicenzo de Paola, A, Paraschos, A, Pardell, H, Park, H, Park, J, Parkash, R, Parker, I, Parrens, E, Parris, R, Passamonti, E, Patel, J, Patel, R, Pentz, W, Persic, V, Perticone, F, Peters, P, Petkar, S, Pezo, L, Pham, D, Cao Phai, G, Phlaum, S, Pineau, J, Pineda Velez, A, Pini, R, Pinter, A, Pinto, F, Pirelli, S, Pivac, N, Pizzini, A, Pocanic, D, Calin Podoleanu, C, Polanczyk, C, Polasek, P, Poljakovic, Z, Pollock, S, Polo, J, Poock, J, Poppert, H, Porro, Y, Pose, A, Poulain, F, Poulard, J, Pouzar, J, Povolny, P, Pozzer, D, Pras, A, Prasad, N, Prevot, S, Protasov, K, Prunier, L, Puleo, J, Pye, M, Qaddoura, F, Quedillac, J, Raev, D, Rahimi, S, Raisaro, A, Rama, B, Ranadive, N, Randall, K, Ranjith, N, Raposo, N, Rashid, H, Raters, C, Rauch Kroehnert, U, Rebane, T, Regner, S, Renzi, M, Reyes Rocha, M, Reza, S, Ria, L, Richter, D, Rickli, H, Rickner, K, Rieker, W, Rigo, F, Ripoll, T, Fonteles Ritt, L, Roberts, D, Pascual, C, Briones, I, Reyes, H, Roelke, M, Roman, M, Romeo, F, Ronner, E, Ronziere, T, Rooyer, F, Rosenbaum, D, Roth, S, Rozkova, N, Rubacek, M, Rubalcava, F, Rubanenko, O, Rubin, A, Borret, M, Rybak, K, Sabbour, H, Morales, O, Sakai, T, Salacata, A, Salecker, I, Salem, A, Salfity, M, Salguero, R, Salvioni, A, Samson, M, Sanchez, G, Sandesara, C, Saporito, W, Sasaoka, T, Sattar, P, Savard, D, Scala, P, Scemama, J, Schaupp, T, Schellinger, P, Scherr, C, Schmitz, K, Schmitz, B, Schmitz, L, Schnitzler, R, Schnupp, S, Schoeniger, P, Schön, N, Schuster, S, Schwimmbeck, P, Seamark, C, Seebass, R, Seidl, K, Seidman, B, Sek, J, Sekaran, L, Seko, Y, Sepulveda Varela, P, Sevilla, B, Shah, V, Shah, A, Shah, N, Shanes, J, Sharareh, A, Sharma, V, Shaw, L, Shimizu, Y, Shimomura, H, Shin, D, Shin, E, Shite, J, Shoukfeh, M, Shoultz, C, Silver, F, Sime, I, Simmers, T, Singal, D, Singh, N, Siostrzonek, P, Sirajuddin, M, Skeppholm, M, Smadja, D, Smith, R, Smith, D, Soda, H, Sofley, C, Sokal, A, Sotolongo, R, de Souza, O, Sparby, J, Spinar, J, Sprigings, D, Spyropoulos, A, Stakos, D, Steinberg, A, Steinwender, C, Stergiou, G, Stites, H, Stoikov, A, Strasser, R, Streb, W, Styliadis, I, Su, G, Su, X, Suarez, R, Sudnik, W, Sueyoshi, A, Sukles, K, Sun, L, Suneja, R, Svensson, P, Ziekenhuis, A, Szavits Nossan, J, Taggeselle, J, Takagi, Y, Takhar, A, Tallet, J, Tamm, A, Tanaka, S, Tanaka, K, Tang, A, Tang, S, Tassinari, T, Tayama, S, Tayebjee, M, Tebbe, U, Teixeira, J, Tesloianu, D, Tessier, P, The, S, Thevenin, J, Thomas, H, Timsit, S, Topkis, R, Torosoff, M, Touze, E, Traissac, T, Trendafilova, E, Troyan, B, Tsai, W, Tse, H, Tsutsui, H, Tsutsui, T, Tuininga, Y, Turakhia, M, Turk, S, Turner, W, Tveit, A, Twiddy, S, Tytus, R, Ukrainski, G, Valdovinos Chavez, S, Van De Graaff, E, Vanacker, P, Vardas, P, Vargas, M, Vassilikos, V, Vazquez, J, Venkataraman, A, Verdecchia, P, Vester, E, Vial, H, Vinereanu, D, Vlastaris, A, Vogel, C, vom Dahl, J, von Mering, M, Vora, K, Wakefield, P, Walia, J, Walter, T, Wang, M, Wang, N, Wang, F, Wang, X, Wang, Z, Wang, K, Watanabe, K, Wei, J, Weimar, C, Weinrich, R, Wen, M, Wheelan, K, Wicke, J, Wiemer, M, Wild, B, Wilke, A, Willems, S, Williams, M, Williams, D, Winkler, A, Wirtz, J, Witzenbichler, B, Wong, D, Lawrence Wong, K, Wong, B, Wozakowska Kaplon, B, Wu, Z, Wu, S, Wyatt, N, Xu, Y, Xu, X, Yamada, A, Yamamoto, K, Yamanoue, H, Yamashita, T, Bryan Yan, P, Yang, Y, Yang, T, Yao, J, Yarlagadda, C, Yeh, K, Yotov, Y, Yvorra, S, Zahn, R, Zamorano, J, Zanini, R, Zarich, S, Zebrack, J, Zenin, S, Zeuthen, E, Zhang, X, Zhang, Q, Zhang, D, Zhang, H, Zhao, S, Zhao, X, Zheng, Y, Zheng, Q, Zhou, J, Zimmermann, S, Zimmermann, R, Zukerman, L, and Zwaan van der, C

Subjects
Male, oral anticoagulation, Internationality, Middle Aged, registry, Antithrombins, Dabigatran, Stroke, Cross-Sectional Studies, Fibrinolytic Agents, Humans, Female, atrial fibrillation, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine, Aged, Atrial Fibrillation
Abstract

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)

Published
2017

237. Improve benzene production from refinery sources: a new cracking route reduces cost of benzene while coproducing ethylene. (Process Technology-Petrochemical)

Author

Netzer, D. and Ghalayini, O.J.

Subjects
Pesticides industry -- Production management, Hydrocarbons -- Production management, Herbicides -- Production management, Organic compounds, Chemical industry -- Production management, Business, Petroleum, energy and mining industries, Production management
Abstract

Benzene is the building block for several major commodity petrochemicals. It is mainly recovered from refinery catalytic reforming streams and furthered purified for petrochemical applications. Traditional product processing steps alkylate [...]

Published
2002

238. Modeling and forecasting spot oil price

Author

Latife Ghalayini

Subjects
Short run, Financial economics, Crack spread, 05 social sciences, Economics, Econometrics and Finance (miscellaneous), Oil-storage trade, General Business, Management and Accounting, Exchange rate, 0502 economics and business, Oil demand, Econometrics, Economics, 050207 economics, Oil price, Volatility (finance), Speculation, 050205 econometrics
Abstract

The aim of this paper is to explore the reasons of oil price volatility. It analyses the information function of oil future market and investigates the relation between speculation and spot oil price in the short run. Furthermore, the paper constructs a model for long run equilibrium able to produce reliable and reasonable oil price forecasts. Findings prove that in the short run, changes in oil inventories Granger cause changes in oil price. In the long run however, findings prove that, the oil demand, the oil supply, the $/SDR exchange rate, the speculation in oil future market (New York Mercantile Exchange) and the oil inventories are associated in a long run relationship.

Published
2016
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239. Growth of layer-bound normal faults under a regional anisotropic stress field

Author

Jean-Marc Daniel, Fadi H. Nader, Ramadan Ghalayini, Catherine Homberg, Institut des Sciences de la Terre de Paris (iSTeP), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010504 meteorology & atmospheric sciences, Condensed matter physics, Field (physics), [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Geology, Ocean Engineering, 010502 geochemistry & geophysics, 01 natural sciences, Anisotropic stress, Layer (electronics), ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Water Science and Technology
Abstract

International audience

Published
2016
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242. Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects inDrosophila-Expressing Alzheimer’s Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System

Author

Konstantin G. Iliadi, Shin-Hann Lee, Gabrielle L. Boulianne, Judy Ghalayini, and Sarah M. Gomes

Subjects
Programmed cell death, General Neuroscience, Transgene, Angiotensin-converting enzyme, Captopril, General Medicine, Pharmacology, Biology, Presenilin, Losartan, Renin–angiotensin system, medicine, biology.protein, Cognitive decline, medicine.drug
Abstract

Alzheimer’s disease (AD) is a degenerative disorder that causes progressive memory and cognitive decline. Recently, studies have reported that inhibitors of the mammalian renin angiotensin system (RAS) result in a significant reduction in the incidence and progression of AD by unknown mechanisms. Here, we used a genetic and pharmacological approach to evaluate the beneficial effects of Angiotensin Converting Enzyme Inhibitors (ACE-Is) and Angiotensin Receptor Blockers (ARBs) in Drosophila expressing AD-related transgenes. Importantly, while ACE orthologs have been identified in Drosophila, other RAS components are not conserved. We show that captopril, an ACE-I, and losartan, an ARB, can suppress a rough eye phenotype and brain cell death in flies expressing a mutant human C99 transgene. Captopril also significantly rescues memory defects in these flies. Similarly, both drugs reduce cell death in Drosophila expressing human Aβ42 and losartan significantly rescues memory deficits. However, neither drug affects production, accumulation or clearance of Aβ42. Importantly, neither drug rescued brain cell death in Drosophila expressing human Tau suggesting that RAS inhibitors specifically target the amyloid pathway. Of note, we also observed reduced cell death and a complete rescue of memory deficits when we crossed a null mutation in Drosophila Acer into each transgenic line demonstrating that the target of captopril in Drosophila is Acer. Altogether, these studies demonstrate that captopril and losartan are able to modulate AD related phenotypes in the absence of the canonical RAS pathway and suggest that both drugs have additional targets that can be identified in Drosophila. Significance Statement AD is a devastating neurodegenerative disorder for which there is no cure. Recently, studies have reported a significant reduction in the incidence of AD and dementia among patients taking ACE-Is and ARBs. Given the enormous and immediate potential of ACE-Is and ARBs for AD therapeutics, it is imperative that we understand how they function and why they are beneficial in some patients but not others. Here we show that captopril, an ACE-I, and losartan, an ARB, can restore memory defects in flies expressing human AD transgenes in the absence of the canonical RAS pathway. These studies provide us with a unique opportunity to identify novel targets of ACE-Is and ARBs and evaluate their therapeutic effectiveness in robust models of AD.

Published
2020
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243. Financial integration in the United Arab Emirates Stock Markets

Author

Rim Ghalayini, Jose Olmo, and Burcu Kapar

Subjects
Market integration, Error correction model, Cointegration, Short run, Financial economics, Stock exchange, Financial market, Economics, Financial integration, Finance, Stock (geology)
Abstract

This paper examines the integration of financial markets using data from the Dubai Financial Market Stock Exchange, Abu Dhabi Stock Exchange and the FTSE Nasdaq Dubai UAE 20 index. To do this, we apply a vector error correction model and a permanent-transitory decomposition of the series of prices. Our results reveal the existence of a long-run equilibrium relationship between the three financial indices suggesting that UAE stock markets are integrated. Shocks to any of these markets affect the other markets in the long and the short run through the equilibrium condition. We uncover a major role of the FTSE Nasdaq Dubai UAE 20 index in this equilibrium relationship. Our analysis of market integration also allows us to obtain a permanent-transitory decomposition given by two common factors that drive the three financial indices. Whereas the first factor is defined as a weighted combination of the two major financial indices the second factor is mainly determined by the FTSE Nasdaq Dubai. As a byproduct of our analysis, we find empirical evidence of short-run and long-run predictability running from the Dubai financial indices to the Abu Dhabi index.

Published
2020
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245. Nutritional programming by maternal obesity: insights into the development of non-alcoholic fatty liver disease

Author

Judy, Ghalayini and Shin-Hann, Lee

Subjects
Glucose, Molecular and cellular, Non-alcoholic Fatty Liver Disease, Pregnancy, Animals, Humans, Insulin, Female, Lipid Metabolism, Transcriptome, Rats
Abstract

KEY POINTS: Maternal high‐fat diet consumption predisposes to metabolic dysfunction in male and female offspring at young adulthood. Maternal obesity programs non‐alcoholic fatty liver disease (NAFLD) in a sex‐dependent manner. We demonstrate sex‐dependent liver transcriptome profiles in rat offspring of obese mothers. In this study, we focused on pathways related to insulin, glucose and lipid signalling. These results improve understanding of the mechanisms by which a maternal high‐fat diet affects the offspring. ABSTRACT: Maternal obesity (MO) predisposes offspring (F1) to obesity, insulin resistance (IR) and non‐alcoholic fatty liver disease (NAFLD). MO's effects on the F1 liver transcriptome are poorly understood. We used RNA‐seq to determine the liver transcriptome of male and female F1 of MO and control‐fed mothers. We hypothesized that MO‐F1 are predisposed to sex‐dependent adult liver dysfunction. Female Wistar rat mothers ate a control (C) or obesogenic (MO) diet from the time they were weaned through breeding at postnatal day (PND) 120, delivery and lactation. After weaning, all male and female F1 ate a control diet. At PND 110, F1 serum, liver and fat were collected to analyse metabolites, histology and liver differentially expressed genes. Male and female MO‐F1 showed increased adiposity index, triglycerides, insulin and homeostatic model assessment vs. C‐F1 with similar body weight and glucose serum concentrations. MO‐F1 males presented greater physiological and histological NAFLD characteristics than MO‐F1 females. RNA‐seq revealed 1365 genes significantly changed in male MO‐F1 liver and only 70 genes in female MO‐F1 compared with controls. GO and KEGG analysis identified differentially expressed genes related to metabolic processes. Male MO‐F1 liver showed the following altered pathways: insulin signalling (22 genes), phospholipase D signalling (14 genes), NAFLD (13 genes) and glycolysis/gluconeogenesis (7 genes). In contrast, few genes were altered in these pathways in MO‐F1 females. In summary, MO programs sex‐dependent F1 changes in insulin, glucose and lipid signalling pathways, leading to liver dysfunction and insulin resistance.

Published
2018

246. Using polygonal layer-bound normal faults as tools to delimit clastic reservoirs in the Levant Basin offshore Lebanon

Author

Ghalayini, Ramadan and Eid, Celine

Subjects
bepress|Physical Sciences and Mathematics, bepress|Physical Sciences and Mathematics|Earth Sciences|Sedimentology, EarthArXiv|Physical Sciences and Mathematics|Earth Sciences|Geology, bepress|Physical Sciences and Mathematics|Earth Sciences|Geology, bepress|Physical Sciences and Mathematics|Earth Sciences|Tectonics and Structure, EarthArXiv|Physical Sciences and Mathematics|Earth Sciences|Tectonics and Structure, bepress|Physical Sciences and Mathematics|Earth Sciences, EarthArXiv|Physical Sciences and Mathematics|Earth Sciences, EarthArXiv|Physical Sciences and Mathematics|Earth Sciences|Sedimentology, EarthArXiv|Physical Sciences and Mathematics
Abstract

The Levant Basin offshore Lebanon contains an array of layer-bound normal faults in the Oligo-Miocene units. The faults are believed to have nucleated in soft-grained sediments similar to polygonal fault systems worldwide, and as a result are influenced by lithological heterogeneities in the host rock unit. We used 3D seismic data and amplitude extraction from offshore Lebanon to map deepwater channels and fan lobes, and demonstrate that the distribution, geometry and growth of the layer-bound normal faults is affected by these sedimentary bodies which are acting as barriers to fault propagation. Three fault types are identified, differentiated by their growth models and overall geometry. Type I faults in the deep basin indicate that a competent unit is present along the base Miocene and is affecting their growth. Type II and III faults in the Lattakia Ridge and the margin respectively are smaller due to restriction by Upper Miocene and Lower Oligocene basin floor fans. Based on their seismic expression and on analogy with other basins containing similar faults, we deduce that the units causing restriction consist of sand rich intervals. Therefore, reservoirs offshore Lebanon are probably along the base Miocene in the deep basin, while in the Lattakia Ridge and the Levant margin, reservoirs are in Upper Miocene and in Lower Oligocene units. This study provides an additional evidence that layer-bound, or polygonal faults, can have practical industrial application during exploration of hydrocarbons, even in the absence of well data.

Published
2018
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247. Evolution of a Dominant Natural Isolate of Escherichia coli in the Human Gut over the Course of a Year Suggests a Neutral Evolution with Reduced Effective Population Size

Author

Mohamed Ghalayini, Olivier Clermont, Antoine Bridier-Nahmias, Olivier Tenaillon, Adrien Launay, Erick Denamur, and Mathilde Lescat

Subjects
0301 basic medicine, Mutation rate, 030106 microbiology, Clone (cell biology), Genetics and Molecular Biology, Biology, medicine.disease_cause, Applied Microbiology and Biotechnology, Evolution, Molecular, 03 medical and health sciences, Feces, Effective population size, Mutation Rate, Molecular evolution, medicine, Escherichia coli, Humans, Symbiosis, Genetics, Population Density, Experimental evolution, Ecology, Genetic Drift, Genetic Variation, Biodiversity, Chromosomes, Bacterial, Adaptation, Physiological, Gastrointestinal Tract, 030104 developmental biology, Genes, Bacterial, Mutation, Adaptation, Neutral theory of molecular evolution, Food Science, Biotechnology
Abstract

In vitro and in vivo evolution experiments on Escherichia coli revealed several principles of bacterial adaptation. However, few data are available in the literature describing the behavior of E. coli in its natural environment. We attempted here to study the evolution in the human gut of a commensal dominant E. coli clone, ED1a belonging to the B2 phylogroup, through a longitudinal genomic study. We sequenced 24 isolates sampled at three different time points within a healthy individual over almost a year. We computed a mutation rate of 6.90 × 10 −7 mutations per base per year of the chromosome for E. coli ED1a in healthy human gut. We observed very limited genomic diversity and could not detect any evidence of selection, in contrast to what is observed in experimental evolution over a similar length of time. We therefore suggest that ED1a, being well adapted to the healthy human gut, evolves mostly neutrally with a low effective population size ( N e of ≈500 to 1,700). IMPORTANCE In this study, we follow the genomic fate of a dominant clone of Escherichia coli in the human gut of a healthy individual over about a year. We could compute a low annual mutation rate that supports low diversity, and we could not retrieve any clear signature of selection. These observations support a neutral evolution of E. coli in the human gut, compatible with a very limited effective population size that deviates drastically with the observations made previously in experimental evolution.

Published
2018

248. Key geological characteristics of the Saida-Tyr Platform along the eastern margin of the Levant Basin, offshore Lebanon: implications for hydrocarbon exploration

Author

Ramadan Ghalayini, Nicolas Hawie, Lama Inati, Samer Bou Daher, and Fadi H. Nader

Subjects
010504 meteorology & atmospheric sciences, General Chemical Engineering, Anticline, Energy Engineering and Power Technology, Structural basin, Geodynamics, 010502 geochemistry & geophysics, lcsh:Chemical technology, lcsh:HD9502-9502.5, 01 natural sciences, Cretaceous, lcsh:Energy industries. Energy policy. Fuel trade, Paleontology, Fuel Technology, Stratigraphy, Source rock, lcsh:TP1-1185, Structural geology, Hydrocarbon exploration, Geology, 0105 earth and related environmental sciences
Abstract

More than 60 trillion cubic feet (Tcf) of natural gas have been recently discovered in the Levant Basin (eastern Mediterranean region) offshore Cyprus, Egypt and Israel, Palestine. Un-explored areas, such as the Lebanese offshore, may yield additional discoveries. This contribution focuses the Saida-Tyr Platform (STP), an offshore geological feature adjacent to the southern Lebanese coastline – part of the eastern margin of the Levant Basin. First, an extensive synthesis of recent published research work, tackling crustal modeling, structural geology and stratigraphy will be presented. Then, a new local crustal model and the interpretation of seismic reflection specifically on the STP are discussed and emplaced in the context of the upcoming petroleum exploration activities in this region. Characteristic structural features form the limits of the STP which is believed to be an extension of the Arabian continent into the Levant Basin. Its westernmost limit consists of the extension of the crustal interface, previously termed “hinge zone”, where major plate-scale deformations are preferentially localized. The northward extension of this “hinge zone” beyond the STP can be mapped by means of major similar deformation structures (i.e.S-N-trending anticlines) and can be associated to the Levant Fracture System (LFS) – the northwestern border of the Arabian plate. The northern limit of the STP (i.e.the Saida Fault) is a typical E-W, presently active, structure that is inherited from an older, deeply rooted regional fault system, extending eastward throughout the Palmyra Basin. The STP is characterized by a variety of potential plays for hydrocarbon exploration. Jurassic and Cretaceous clastics and carbonates are believed to include reservoir plays, which could have been charged by deeper Mesozoic source rocks, and sealed by Upper Cretaceous marly layers. The edge of the Cretaceous carbonate platforms and potential carbonate buildups are well recognizable on seismic reflection profiles. The western and northern anticlinal structures bordering the STP are excellent targets for Oligo-Miocene biogenic gas charging systems. Based on integrating geodynamics, tectono-stratigraphic interpretations and petroleum systems analyses, such plays are well constrained and the exploration risk is therefore lowered.

Published
2018
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249. Comment associer de manière optimale l'utilisateur lors d'un contrat de Partenariat Public-Privé pour la construction d'un établissement universitaire ?

Author

Ghalayini, Ibrahim and Girard, Vivien

Subjects
[SHS] Humanities and Social Sciences
Abstract

Les partenariats publics-privés permettent à la personne publique, après une période de dialogue compétitif, de transférer la maîtrise d'ouvrage et du financement à une société créée ex-nihilo. Cette société, dite société de projet, assure le financement, la construction, l'exploitation et la maintenance de l'ouvrage sur une durée déterminée dans le cadre d'un contrat. Une étude particulière a pu être portée sur la construction du pôle Biologie-Pharmacie-Chimie de l'Université Paris Sud, objet d'un PPP. A la suite de l'étude du dialogue compétitif et des groupes utilisateurs en phase conception, des préconisations peuvent être faites : recueillir et trier les remarques des utilisateurs sur les plans PRO, or-ganiser des visites de chantier et les former au bon usage du bâtiment. Afin d'élargir l'étude sur d'autres projets, j'ai effectué des entretiens, desquels découlent trois axes stra-tégiques pour la bonne conduite d'une opération en PPP : l'organisation de la personne publique, l'art de la concertation et de la communication et l'accompagnement au chan-gement. Enfin, des recommandations sont faites pour un conducteur d'opération en PPP portant sur : l'analyse de l'organisation de l'Université, sa position vis-à-vis de l'Universi-té, de l'élaboration du programme, de la transparence du projet, de l'accompagnement au changement et de l'anticipation de l'évolution des demandes.

Published
2018

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