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ObjectivesThe Filtered Far-UVC (FFUV) handheld disinfection device is a small portable device that emits far UVC at 222nm. The objective of this study was to evaluate the device’s ability to kill microbial pathogens on hospital surfaces and compare it to manual disinfection using germicidal sodium hypochlorite wipes.MethodsA total of 344 observations (4 observations from 86 objects’ surfaces) were sampled with 2 paired samples per surface: a pre- and a post-sodium hypochlorite, and a pre- and a post-FFUV samples. The results were analyzed via a Bayesian multilevel negative binomial regression model. Additionally, the bacterial flora recovered were identified using mass spectrometry.ResultsThe estimated mean colony counts for the sodium hypochlorite control and treatment groups were 20.5 (11.7 – 36.0) and 0.1 (0.0 – 0.2) colony forming units (CFUs) respectively. The FFUV control and treatment groups had mean colony counts of 22.2 (12.5 – 40.1) and 4.1 (2.3 – 7.2) CFUs. The sodium hypochlorite samples had an estimated 99.4% (99.0% – 99.7%) reduction in colony counts, while those from the FFUV group had an 81.4% (76.2% − 85.7%) reduction.ConclusionsOur study demonstrated that FFUV handheld device effectively reduced microbial bioburden on surfaces in the healthcare setting. Several healthcare-associated infections (HAIs) causing pathogens (gram positive and negative bacteria) were retrieved from the pre-clean surfaces. The major benefit of FFUV is likely seen when manual disinfection is not possible or when supplementing cleaners or disinfectants with the low-level disinfection properties.

1AbstractTreatment of acute and chronic pain represent a widespread clinical challenge with poor therapeutic options. While rodents are an invaluable model to study pain, scoring nociceptive responses in clinically relevant paradigms and at high-throughput remains an unmet challenge. Therefore, there is a need for automated, high-throughput methods that sensitively and accurately assess pain and analgesia. Such objective and scalable technologies will enable the discovery of novel analgesics and yield mechanistic insights into the neural and genetic mechanisms of pain. Here, we adopt the open field arena to build a univariate scale for the formalin injection model of inflammatory pain by using a machine learning approach that incorporates 82 behavioral features. This tool outperforms traditional measures of licking and shaking in detection of formalin dose, and was validated using 4 diverse mouse strains. We also detected previously unreported differences in formalin induced nocifensive behaviors that were strain and sex specific. This model also reliably identifies morphine induced antinociception. This novel, sensitive, and inexpensive tool provides a method for quantifying voluntary nociceptive responses to facilitate genetic mapping and analgesic compound screening in a high throughput manner.

Background: Polycystic ovarian syndrome (PCOS)is common gynecological endocrinopathy characterized by chronic anovulation and hyperandrogenism affecting 5-10% of women worldwide. It is a heterogenous, multifactorial, complex genetic disorder with uncertain etiology and is one of the most common treatable cause of infertility. AIM: To study the various clinical presentations in polycystic ovarian syndrome. MATERIALS AND METHODS: Present study is cross sectional observational study carried out in tertiary care centre. This study was performed in the Out Patient Department of Obstetrics and Gynecology. RESULTS: The mean age of 41 patients in the study was 23.6 years. Most common presenting symptom in patients is menstrual irregularities (89%) followed by infertility and hirsutism. USG (abdo+pelvis) showing polycystic ovarian syndrome ovaries. Around 39% patients with PCOS developed insulin resistance. KEYWORDS: - Amenorrhea, Infertility, Oligomenorrhea, Polycystic Ovarian Syndrome.

Background: Pregnancy beyond term is associated with adverse maternal and perinatal outcome. The aim of the study the maternal and perinatal outcome in pregnancies at and beyond 41 week of gestation. Methods: This is a prospective study of 140 patients with pregnancy beyond 41 weeks fulfilling the eligibility criteria and admitted and delivered in department of obstetrics and gynaecology at a tertiary care hospital. We examined its association with following outcomes: age, parity, genetic factors, bishop’s score at admission, mode of delivery, induction rate, meconium stained amniotic fluid, oligohydramnios, Perinatal and neonatal morbidity, Perineal tear, postpartum haemorrhage, maternal morbidity and mortality etc. Results: Out of 140 patients, majority in the age group of 21-25 years, 68 (48.6%) patients were primigravida while 72 (51.4%) patients were multigravida. Maximum patients 65% were not in labour whereas 35% were in labour. In 51 (36.4%) patients mode of delivery was caesarean section, in which most common indication being foetal distress in 25.5% followed by meconium stained amniotic fluid in 17.6%. In present study perinatal morbidity like stillbirth, RDS were 2.86% & 25.8% respectively. Maternal morbidity like PPH, tear and wound infection were 4.31%, 6.4%, 0.7%respectively. Conclusions: With Regular antenatal check-up, incidence of post term pregnancy can be decreased and Labour induction should be considered at 41weeks to prevent lot of maternal and perinatal complications.

Background: One of the main factors affecting maternal morbidity and mortality is the decision to delivery interval (DDI) that is, the time taken from the decision to take the patient up for caesarean section to the delivery of the fetus. Method: This is a retrospective observational study conducted over a period of twelve months where 370 patients were studied. Results: No delay was seen in 49.2% cases whereas most delay was noted after decision by obstetricians to transfer patient to OT (22.2%). Conclusion: In order to get favourable maternal and fetal outcome decision to delivery interval should be within 30 minutes and this can be made possible if factors like results of blood investigations and cross matching of blood can be made available on time.