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Adequate nutrition is especially important during infancy and childhood, where even short periods of malnutrition have long-lasting effects on growth, development and health in adult life. There are several high-risk scenarios for the development of malnutrition, which are the focus of the current publication: Atopic diseases, gastrointestinal disorders, and preterm delivery. For the pediatric allergist it is important to understand the mechanisms regulating IgE responses to food proteins since they may also be the earliest markers for the atopic march. As breastfeeding seems to have only limited effects regarding the atopic march, other measures to modulate infantile immune responses have to be taken, including the use of hypoallergenic formulae or the addition of probiotics or prebiotics to infant formulae. The second part of this book highlights the functional properties of nutrition with regard to diseases of the gastrointestinal tract and the ensuing chronic alterations of gastrointestinal function. Topics addressed include the molecular basis of some diseases, main causes of and nutritional measures in chronic enteropathy, including the role of parenteral and enteral nutrition, stressed mucosa and the role of nutrition in cholestatic liver disease. Nowadays, smaller and more immature infants are surviving - but the smaller the infant, the greater the accrued deficit as nutritional needs change with advancing maturity, and one formulation may not meet all requirements. Furthermore, there are no sensitive, accurate and precise measures of nutritional outcome. The net effect of these uncertainties is that all very-low-birth-weight infants are growth retarded at hospital discharge. Strategies for improving growth in these high-risk infants are at the center of the last part of this publication.

Table 1 Cancer is the second most common cause of death in Americans (see www.cdc.gov). Colorectal cancer kills more Incidence and Mortality of the Five Most Common Gastrointestinal Malignancies Americans than any other malignancy except for lung cancer. The incidences and mortalities of the major gastrointestinal a a Site Incidence Mortality (GI) malignancies are shown in Table 1. Taken as a group, the five most common GI malignancies account for more cancers Colorectum 53.9 21.6 and more cancer deaths than for any other site. Pancreas 11.1 10.6 Stomach 9.1 4.9 Flexible endoscopy has given physicians unprecedented Liver/intrahepatic bile ducts 6.2 4.4 access to the GI tract. The ability to endoscopically visu- Esophagus 4.5 4.3 alize, biopsy, and apply therapy has had implications for the management of all the major GI malignancies. Accepted Data from SEER database 1992–2002 (www.seer.cancer.gov). applications of endoscopy range from detection of mal- a Per 100,000.

Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.

Covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract. It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits. This new book is ideal for gastroenterologists (including trainees/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.

infection is recognized as the most common cause of gastritis, and it is etiologically involved in the genesis of gastric ulcers, duodenal ulcers, and gastric adenocarcinoma. This handbook presents an in-depth review of the accurate diagnosis of and effective treatment options for H pylori gastrointestinal infections.

Many nurses work as specialist practitioners within several areas of gastrointestinal medicine, including inflammatory bowel disease, stoma care, nutrition, endoscopy and counselling. There has been a steady increase in nurse-led services and gastrointestinal nursing is an expanding area. This comprehensive text lays the foundation by reviewing the anatomy and physiology underlying common conditions before covering the pathophysiology of clinical features, causes, investigation and management. Underlying this approach will be the specific nursing aspects of caring for patients with gastrointestinal conditions, covering psychosocial factors and issues such as the measurement of health related quality of life.

Written in a quick-review format perfect for the busy student and clinician, this Second Edition stands as the most illustrative and in-depth guide available to prepare for the gastroenterology board and recertification exams. Supplying readers with an armamentarium of case-based presentations, 219 quality images, and more than 400 references for f

The latest system based addition to the At a Glance series, The Gastrointestinal System at a Glance is a concise and integrated text on the gastrointestinal system. The book is intended as an authoritative and concise account of the field covering anatomy, physiology, biochemistry, pharmacology, and pathology as well as clinical management. The book is divided in to four sections: Basic Structure and Function, Integrated Function and Disorders and Diseases as well as a short section on Diagnosis and Treatment. The structure of the book takes the student from the basic sciences to clinical practice whilst always maintaining an integrated balance and understanding of both aspects. Fantastic diagrams that include a quick summary of clinical presentations will aid students to learn and revise. The Gastrointestinal System at a Glance is ideal as an introduction to the subject, as a companion book for a course, and as a book for revision prior to examinations.

Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.

Traditional textbooks in this field have emphasized the basic sciences of pathology, biochemistry and physiology. Evidence-based Gastroenterology and Hepatology covers all the major diseases of the gastrointestinal tract and liver, utilizing clinical epidemiology to present the strongest and most current evidence for interventions. This second edition is edited and written by leading gastroenterologists from around the world, each chapter summarizes the evidence so that better informed decisions will be made about which treatments to offer to patients. It provides practising Gastroenterologists and Surgeons with clear information regarding the diagnosis and treatment of pancreatic diseases, giving clear evidence and experience-based material that is immediately relevant to clinical practice. Also contains a list of recommended reading at the end of each chapter. Take a look at up to date information at www.evidbasedgastro.com

Laparoscopic Surgery of the Abdomen is intended to give the practicing surgeon or trainee an in-depth analysis of the technical aspects of the most commonly performed laparoscopic procedures, their indications, contraindications, and complications. Included are strategies to prevent complications as well as ways to handle them once they occur. Heavily illustrated, the book breaks new ground in visualizing operative procedures and problems. Seven sections, comprising the core curriculum of accepted procedures in laparoscopic surgery, present gallbladder disease, common bile duct exploration, hernia, colon diseases, anti-reflux procedures, acute abdomen and the role of diagnostic laparoscopy, and emerging procedures on the spleen and adrenals. Recognized leaders in the field tackle each section, emphasizing what to do when and how to solve acute situations. Laparoscopic Surgery of the Abdomen is a practical, must-have resource for the general surgeon, imparting the clinical insight needed for successful performance of the core miminally invasive procedures as well as a source of useful patient information for the office practice.

Includes index.

Morson and Dawson's Gastrointestinal Pathology is one of the'Gold Standards'of pathology textbooks. It has been completely revised to incorporate the latest advances in this rapidly evolving field including the developments in gastric cancer and Helicobacter pylori and the revised classification of other common gastrointestinal conditions. This new edition features a wealth of new material presented in full colour for the first time.

Practical Gastroenterology is aimed at the specialist trainee and new consultant in practice. Focusing primarily on day-to-day management issues, it is structured to reflect the way the problems present and are managed in the hospital, such as whether patients are seen as inpatients or outpatients. Its approach is clinically-orientated. An introduc

Even though the knowledge of the pathogenesis of cancers and inflammatory diseases of the gastrointestinal tract has greatly increased in recent years, their clinical management remains a challenge. Detailing the clinical potential of new technologies and opportunities that may have a rapid impact on the everyday management of patients, this publication intends to bridge the gap between basic research and clinical application. The first three reviews focus on new technologies, namely proteome analysis, DNA methylation and DNA array analysis in the management of GI cancer patients. Subsequent papers describe recent advances in the diagnosis of colon cancer by molecular analysis and the lately unraveled genetic alterations underlying chronic inflammatory diseases of the colon and pancreas. Last but not least, ethical considerations associated with mass screening of GI patients and the role of patients in the development of diagnostic and prognostic studies are discussed. Reconciling new technologies with clinical research, this publication will be of great interest for those involved in the daily management of GI diseases.

With the dramatic increase of the aging population, the study and care of gastrointestinal disorders in the elderly have become priority topics for both clinicians and researchers. The geriatric approach which includes the epidemiology and pharmacokinetics of drugs as well as a comprehensive multidimensional assessment is particularly important in managing older patients with gastrointestinal disorders, since these patients are likely to have multiple interacting problems that interfere with their daily function and complicate their treatment. This book presents the results of recent studies in geriatric gastroenterology and reviews both basic and clinical aspects of the field. An important section is devoted to the close examination of the structural and functional effects of aging on the physiology of the gastrointestinal tract. Recent advances in diagnostic tools and the treatment of elderly patients with dysphagia and gastroesophageal reflux disease as well as with NSAID-related or Helicobacter pylori-associated gastroduodenal diseases are reported in updated chapters. The physician's approach to the management of disorders of the small intestine, colon, pancreas and liver is discussed, highlighting the specific aspects of such disorders in old age. As it is important that the geriatric assessment of elderly patients is carried out by a multidisciplinary team which includes experienced specialists as well as primary care physicians and community health workers, the book addresses a wide readership: general physicians, specialists in geriatrics and gastroenterology and health care providers involved in planning care for elderly patients with gastrointestinal disorders.

This new ABC concentrating on major upper Gastrointestinal disorders reflects the latest advances in understanding of the pathophysiology and pathogenesis of upper GI diseases most of which now have precise diagnostic methods and relational and effective medical and surgical managements.

Clinic Handbook: Gastroenterology provides practical guidelines on the medical and administrative issues associated with running a gastroenterology-based outpatient clinic.Written with all members of the outpatient team in mind, the book provides key information on diagnosis; planning and implementation of treatment; patient education and resource

With the recent development of powerful bioanalytical techniques, research on gluten sensitivity has entered an exciting new phase. In Celiac Disease: Methods and Protocols, Professor Michael N. Marsh, a recognized world authority on this condition, together with a team of other expert laboratory/clinical investigators from around the world present a collection of these state-of-the-art techniques for studying the biology and immunopathology of celiac disease. Both novice and experienced researcher will find in this collection detailed step-by-step methods for cloning lymphocytes, creating gene/peptide libraries, and performing genotyping, linkage, and positional cloning. Also included are techniques for determining the peptide structure of HLA-bound material (tandem mass spectroscopy), computerized morphometry, in situ hybridization, organ culture, and monoclonal AB assays. Comprehensive and cutting-edge, Celiac Disease: Methods and Protocols provides all experimental and clinical investigators with the essential core of readily reproducible methods necessary for successful work on celiac disease today.