Search

El artículo estudia la movilización del campo de organizaciones laicas de inspiración católica e ideología neoconservadora (OLIC-N) contra la Ley de Eutanasia española. A pesar de que la eutanasia constituye el nuevo frente de disputa moral, cultural y político neoconservador, dicha movilización permanece largamente inexplorada; nuestro estudio pretende remediar esta falta. Para ello, se concentra en el repertorio movilizacional y el trabajo identitario realizado por las OLIC-N, analizándolos desde una perspectiva relacional e histórico-comparativa. Así, estudiamos la estructura y dinámicas de red del campo de las OLIC-N y su campo ampliado antiderechos, protagonizado por organizaciones religiosas y partidos políticos conservadores; así como los vínculos entre estas organizaciones, sus narrativas públicas y prácticas sociosimbólicas. Contemplamos, además, el impacto de una estructura de oportunidad política marcada por el Gobierno de coalición progresista PSOE-Unidas Podemos, la crisis sociosanitaria desencadenada por el COVID-19 y la llegada del partido de extrema derecha VOX al Congreso.

BackgroundThe involvement of non-human-to-human transmission of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) remains elusive. Foodstuffs may serve as reservoirs for ESBL-PE and contribute to their spread.AimWe aimed to systematically investigate the presence and spatiotemporal distribution of ESBL-PE in diverse unprocessed foodstuffs of different origin purchased in a central European city.MethodsChicken and green (herbs, salad, sprouts, vegetables) samples were collected monthly for two consecutive years, from June 2017 to June 2019, from large supermarket chains and small local food retailers, representing all ten postcode areas of the City of Basel (Switzerland), and the kitchen of the University Hospital Basel (Basel, Switzerland). After enrichment, presumptive ESBL-PE were isolated by selective culture methods and identified by Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. ESBL production was confirmed by phenotypic testing.ResultsAmong 947 food samples, 14.8% were positive for ESBL-PE isolate/s belonging to eight different ESBL-producing bacterial species. Escherichia coli and Serratia fonticola were predominant across samples (9 and 2%, respectively). Higher ESBL-PE prevalence was observed in chicken (25.9%) than in green (3.8%) samples (p

The molecular mechanisms underlying metastasis in pheochromocytoma/paraganglioma (mPPGL) remain to be explored. Here, the authors perform genomic and immunogenomic profiling of mPPGL tumors and suggest potential biomarkers for risk of metastasis and immunotherapy response.

Abstract Many kink solutions enjoy internal excitations, called shape modes. In some 1+1d scalar models, such as the ϕ 4 double-well model, when a kink’s shape mode is excited twice it may decay to a ground state kink plus a meson. We analytically calculate the decay rates of both the twice-excited shape mode and also a coherent state corresponding to the classically excited shape mode. In the case of the ϕ 4 model, we find that the latter agrees with the classical result of Manton and Merabet.

Tumour heterogeneity is one of the main characteristics of cancer and can be categorised into inter‐ or intratumour heterogeneity. This heterogeneity has been revealed as one of the key causes of treatment failure and relapse. Precision oncology is an emerging field that seeks to design tailored treatments for each cancer patient according to epidemiological, clinical and omics data. This discipline relies on bioinformatics tools designed to compute scores to prioritise available drugs, with the aim of helping clinicians in treatment selection. In this review, we describe the current approaches for therapy selection depending on which type of tumour heterogeneity is being targeted and the available next‐generation sequencing data. We cover intertumour heterogeneity studies and individual treatment selection using genomics variants, expression data or multi‐omics strategies. We also describe intratumour dissection through clonal inference and single‐cell transcriptomics, in each case providing bioinformatics tools for tailored treatment selection. Finally, we discuss how these therapy selection workflows could be integrated into the clinical practice.

The 2030 Agenda was approved by the General Assembly in 2015. However, its resolutions are not legally binding, so it is unclear what kind of obligations it establishes and the possible international liability that would arise from non-compliance. Being an instrument of soft law or soft law, its application depends to a greater extent on the acceptance of the states, which is a political advantage that should not be underestimated. Also, soft law rules often drive the development of international law, helping to lay the foundation for codification and even facilitating the creation of customary international law. This article aims to analyze the legal nature of the Agenda from an international normative point of view and also examine how its content can be articulated in accordance with International Law for states and for companies as non-state actors whose role is key in achieving the Sustainable Development Goals (SDGs).

En este artículo de caso clínico, presentamos como el Farmacéutico Comunitario podría integrar durante la práctica farmacéutica asistencial los Servicios de Atención Farmacéutica orientados a evaluar y mejorar los resultados de medicamentos en salud. El Servicio Seguimiento Farmacoterapéutico que tiene como objetivo la detección de Problemas Relacionados con los Medicamentos, para la prevención y resolución de Resultados Negativos asociados a la Medicación, permite generar datos relacionados con la Farmacovigilancia; de seguridad y efectividad de los medicamentos a través de la notificación de sospechas de reacciones adversas. Presentamos el caso de un paciente con una erupción cutánea persistente, en el que se despliega un enfoque colaborativo entre el farmacéutico, el médico y el propio paciente para abordar una posible causa subyacente e intervenir ejecutando cambios terapéuticos adecuados.

En este texto os mostramos un relato en movimiento, una forma de construir historias entre un maestro y un profesor universitario que caminan por la naturaleza. Partimos de la necesidad de encuentro en espacios amables en los que dialogar sobre lo que nos ocupa y preocupa. Durante nuestro caminar entrecruzamos temáticas como la escuela pública, el respeto al alumnado y la resistencia al cambio, tratando de desenmarañar los espacios y las fronteras escolares. Las temáticas son la excusa para encontrarnos y mostrar nuevas formas de tomar la palabra mientras creamos narrativas compartidas.