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208. SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity.

Author

Rosichini, Marco, Bordoni, Veronica, Silvestris, Domenico Alessandro, Mariotti, Davide, Matusali, Giulia, Cardinale, Antonella, Zambruno, Giovanna, Condorelli, Angelo Giuseppe, Flamini, Sara, Genah, Shirley, Catanoso, Marialuigia, Del Nonno, Franca, Trezzi, Matteo, Galletti, Lorenzo, De Stefanis, Cristiano, Cicolani, Nicolò, Petrini, Stefania, Quintarelli, Concetta, Agrati, Chiara, and Locatelli, Franco

Abstract

Lymphopenia, particularly when restricted to the T-cell compartment, has been described as one of the major clinical hallmarks in patients with coronavirus disease 2019 (COVID-19) and proposed as an indicator of disease severity. Although several mechanisms fostering COVID-19–related lymphopenia have been described, including cell apoptosis and tissue homing, the underlying causes of the decline in T-cell count and function are still not completely understood. Given that viral infections can directly target thymic microenvironment and impair the process of T-cell generation, we sought to investigate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on thymic function. We performed molecular quantification of T-cell receptor excision circles and κ-deleting recombination excision circles to assess, respectively, T- and B-cell neogenesis in SARS-CoV-2–infected patients. We developed a system for in vitro culture of primary human thymic epithelial cells (TECs) to mechanistically investigate the impact of SARS-CoV-2 on TEC function. We showed that patients with COVID-19 had reduced thymic function that was inversely associated with the severity of the disease. We found that angiotensin-converting enzyme 2, through which SARS-CoV-2 enters the host cells, was expressed by thymic epithelium, and in particular by medullary TECs. We also demonstrated that SARS-CoV-2 can target TECs and downregulate critical genes and pathways associated with epithelial cell adhesion and survival. Our data demonstrate that the human thymus is a target of SARS-CoV-2 and thymic function is altered following infection. These findings expand our current knowledge of the effects of SARS-CoV-2 infection on T-cell homeostasis and suggest that monitoring thymic activity may be a useful marker to predict disease severity and progression. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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211. EuPRAXIA@SPARC_LAB status update

Author

Tschentscher, Thomas, Patthey, Luc, Tiedtke, Kai, Zangrando, Marco, Villa, Fabio, Alesini, David, Anania, Maria P., Angelucci, Marco, Bacci, Alberto, Balerna, Antonella, Bellaveglia, Marco, Biagioni, Angelo, Buonuomo, Bruno, Cantarella, Sergio, Cardelli, Fabio, Carillo, Martina, Carpanese, Mariano, Castellano, Michele, Chiadroni, Enrica, Cianchi, Alessandro, Cioeta, Fara, Conti, Marcello R., Coreno, Marcello, Crincoli, Lucio, Costa, Gemma, Curcio, Alessandro, Doria, Andrea, Del Dotto, Alessio, Del Franco, Mario, Del Giorno, Martina, Di Mitri, Simone, Di Pasquale, Enrico, Di Pirro, Giampiero, Drago, Alessandro, Ebrahimpour, Zeinab, Esposito, Adolfo, Faillace, Luigi, Falone, Antonio, Ferrario, Massimo, Ficcadenti, Luca, Franzini, Giovanni, Galletti, Mario, Gallo, Alessandro, Ghigo, Andrea, Giannessi, Luca, Giribono, Anna, Incremona, Simona, Iovine, Pasqualina, Iungo, Franco, Lauciani, Stefano, Liedl, Andrea, Lollo, Valerio, Lupi, Stefano, Marcelli, Augusto, Mostacci, Andrea, Nguyen, Federico, Opromolla, Michele, Parise, Giammarco, Pellegrino, Luigi, Petralia, Alberto, Petrillo, Vittoria, Piersanti, Luca, Pioli, Stefano, Pompili, Riccardo, Principi, Emiliano, Ricci, Ruggero, Romeo, Stefano, Rossi, Andrea R., Rotundo, Ugo, Sabbatini, Lucia, Selce, Andrea, Spallino, Luisa, Spataro, Bruno, Silvi, Gilles J., Stecchi, Alessandro, Stella, Angelo, Stellato, Francesco, Stocchi, Federica, Vaccarezza, Cristina, Vannozzi, Alessandro, and Vescovi, Sandro

Published
2023
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212. Correction to: Which elderly newly diagnosed glioblastoma patients can benefit from radiotherapy and temozolomide? A PERNO prospective study

Author

Franceschi, Enrico, Depenni, Roberta, Paccapelo, Alexandro, Ermani, Mario, Faedi, Marina, Sturiale, Carmelo, Michiara, Maria, Servadei, Franco, Pavesi, Giacomo, Urbini, Benedetta, Pisanello, Anna, Crisi, Girolamo, Cavallo, Michele A., Dazzi, Claudio, Biasini, Claudia, Bertolini, Federica, Mucciarini, Claudia, Pasini, Giuseppe, Baruzzi, Agostino, Brandes, Alba A., Baruzzi, A., Albani, F., Calbucci, F., D’Alessandro, R., Michelucci, R., Brandes, A., Eusebi, V., Ceruti, S., Fainardi, E., Tamarozzi, R., Emiliani, E., Cavallo, M., Franceschi, E., Tosoni, A., Cavallo, M., Fiorica, F., Valentini, A., Depenni, R., Mucciarini, C., Crisi, G., Sasso, E., Biasini, C., Cavanna, L., Guidetti, D., Marcello, N., Pisanello, A., Cremonini, A. M., Guiducci, G., de Pasqua, S., Testoni, S., Agati, R., Ambrosetto, G., Bacci, A., Baldin, E., Baldrati, A., Barbieri, E., Bartolini, S., Bellavista, E., Bisulli, F., Bonora, E., Bunkheila, F., Carelli, V., Crisci, M., Dall’Occa, P., de Biase, D., Ferro, S., Franceschi, C., Frezza, G., Grasso, V., Leonardi, M., Marucci, G., Morandi, L., Mostacci, B., Palandri, G., Pasini, E., PastoreTrossello, M., Pession, A., Poggi, R., Riguzzi, P., Rinaldi, R., Rizzi, S., Romeo, G., Spagnolli, F., Tinuper, P., Trocino, C., Dall’Agata, M., Frattarelli, M., Gentili, G., Giovannini, A., Iorio, P., Pasquini, U., Galletti, G., Guidi, C., Neri, W., Patuelli, A., Strumia, S., Faedi, M., Casmiro, M., Gamboni, A., Rasi, F., Cruciani, G., Cenni, P., Dazzi, C., Guidi, A. R., Zumaglini, F., Amadori, A., Pasini, G., Pasquinelli, M., Pasquini, E., Polselli, A., Ravasio, A., Viti, B., Sintini, M., Ariatti, A., Bertolini, F., Bigliardi, G., Carpeggiani, P., Cavalleri, F., Meletti, S., Nichelli, P., Pettorelli, E., Pinna, G., Zunarelli, E., Artioli, F., Bernardini, I., Costa, M., Greco, G., Guerzoni, R., Stucchi, C., Iaccarino, C., Ragazzi, M., Rizzi, R., Zuccoli, G., Api, P., Cartei, F., Colella, M., Fallica, E., Farneti, M., Frassoldati, A., Granieri, E., Latini, F., Monetti, C., Saletti, A., Schivalocchi, R., Sarubbo, S., Seraceni, S., Tola, M. R., Urbini, B., Zini, G., Giorgi, C., Montanari, E., Cerasti, D., Crafa, P., Dascola, I., Florindo, I., Giombelli, E., Mazza, S., Ramponi, V., Servadei, F., Silini, E. M., Torelli, P., Immovilli, P., Morelli, N., Vanzo, C., Nobile, C., and The PERNO Study Group

Published
2017
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235. Nutrition intake in critically ill patients with coronavirus disease (COVID-19): A nationwide, multicentre, observational study in Argentina

Author

Chapela, Sebastián Pablo, Manzanares, William, Quesada, Eliana, Reberendo, María Jimena, Baccaro, Fernando, Aversa, Irina, Kecskes, Claudia Elisabeth, Magnifico, Lorena, Gonzalez, Victoria, Bolzicco, Daniela, Baraglia, Nancy, Navarrete, Priscila, Manrique, Ezequiel, Cascaron, María Fernanda, Dietrich, Ailen, Asparch, Jesica, Peralta, Leticia Betiana, Galletti, Cayetano, Capria, María Laura, Lombi, Yamila, Rodriguez, Marian Cecilia, Luna, Camila Ester, and Martinuzzi, Andrés Luciano Nicolas

Abstract

In 2020 the pandemic caused by SARS-COV-2 demanded an enormous number of healthcare resources in order to guarantee adequate treatment and support for those patients. This study aims to assess caloric and protein intake and evaluate its associations with relevant clinical outcomes in critically ill with coronavirus disease (COVID-19) patients.

Published
2023
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241. Évaluation du chronotype chez les enfants et les adolescents atteints de mucoviscidose à l’ère des modulateurs de CFTR (CHRONO-MUCO)

Author

Chen, C., Guyon, A., Gronfier, C., Beydon, N., Corvol, H., Galletti, S., Ioan, I., Laudy, V., Loppinet, T., Portefaix, A., Savadogo, M., Tatopoulos, A., Taytard, J., Thouvenin, G., Reix, P., Franco, P., and Coutier, L.

Abstract

L’apparition de troubles du sommeil (TS) chez l’adulte atteint de mucoviscidose (MV) sous elexacaftor-tezacaftor-ivacaftor (ETI) a été rapportée. Aucune étude sur le chronotype n’a été réalisée sous ETI ni chez l’enfant ni chez l’adulte. L’objectif de l’étude était d’évaluer la nature du chronotype des enfants traités par ETI et leur qualité de sommeil.

Published
2024
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