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2014; 150 (12): 1341 - 1344. doi: 10.1001/jamadermatol.2014.1544 6 Bolduc C, Bissonnette R. Safety and efficacy of Adalimumab for the treatment of severe alopecia areata: case series of three patients. We report a case of Alopecia Areata (AA) in a 28-years-old female patient treated with Adalimumab for Crohn's disease (CD). [Extracted from the article]

Copyright of Conservation Science in Cultural Heritage / Quaderni di Scienza della Conservazione is the property of Salvatore Lorusso and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Continuous monitoring of landslides is of basic importance for understanding their behavior, defining their 3D geometry, and providing a basis for early warning purposes. While a number of instrumentations can be used for tracking surface displacement, only automatic or fixed multi-module inclinometers can be used for continuous monitoring of displacement at depth, providing valuable information for landslide geometry reconstruction. Since these instruments are very expensive, thus rarely used, a low-cost and multi-module fixed inclinometer for continuous landslide monitoring has been developed. In this paper, the electronics of the system, including sensor characteristics and optimization, controlling software, and structure are presented. For system development, a single module prototype was first developed and tested in the field to ensure sufficient measuring performance. Subsequently, the multi-module system was designed, assembled, and tested in controlled conditions. Test results indicate the good performance of the system with a displacement measuring accuracy of 0.37% of the length of the inclinometer chain. The linearity test indicates the high linearity of the measures, especially in the range ±20°, which is the typical operating range of such kinds of instrumentations. The thermal efficiency test indicates the high efficiency of the system in preventing measuring errors caused by thermal drifting. [ABSTRACT FROM AUTHOR]

Dentoskeletal class II malocclusion due to a protruded upper dental arch is a major reason for an orthodontic treatment. In these cases, the correction of class II can be hindered by molar distalization, obtained with 'no-compliance therapy' that involves the use of appliances which minimize the need for such co-operation and attempt to maximize the predictability of results. The aim of this review was to outline the effectiveness of no-compliance fixed orthodontic devices in the molar distalization. After selection according to the inclusion/exclusion criteria, 16 articles from 2000 to 2019 were qualified for the final analysis. The literature shows various no-compliance fixed devices whose effect is to distalize the maxillary molars. The present revision allows to conclude that there is a need to increase the number of studies, especially with regard to the most recently introduced devices in the literature. The analysed studies allow to hypothesize that these appliances act with a minimal variability of molar distalization and disto-inclination among them, although different effects among the appliances can be observed as regards to the anchorage. [ABSTRACT FROM AUTHOR]

Cascading landslides are specific multi-hazard events in which a primary movement triggers successive landslide processes. Areas with dynamic and quickly changing environments are more prone to this type of phenomena. Both the kind and the evolution velocity of a landslide depends on the materials involved. Indeed, rockfalls are generated when rocks fall from a very steep slope, while debris flow and/or mudslides are generated by fine materials like silt and clay after strong water imbibition. These events can amplify the damage caused by the initial trigger and propagate instability along a slope, often resulting in significant environmental and societal impacts. The Morino-Rendinara cascading landslide, situated in the Ernici Mountains along the border of the Abruzzo and Lazio regions (Italy), serves as a notable example of the complexities and devastating consequences associated with such events. In March 2021, a substantial debris flow event obstructed the Liri River, marking the latest step in a series of landslide events. Conventional techniques such as geomorphological observations and geological surveys may not provide exhaustive information to explain the landslide phenomena in progress. For this reason, UAV image acquisition, InSAR interferometry, and pixel offset analysis can be used to improve the knowledge of the mechanism and kinematics of landslide events. In this work, the interferometric data ranged from 3 January 2020 to 24 March 2023, while the pixel offset data covered the period from 2016 to 2022. The choice of such an extensive data window provided comprehensive insight into the investigated events, including the possibility of identifying other unrecorded events and aiding in the development of more effective mitigation strategies. Furthermore, to supplement the analysis, a specific finite element method for slope stability analysis was used to reconstruct the deep geometry of the system, emphasizing the effect of groundwater-level flow on slope stability. All of the findings indicate that major landslide activities were concentrated during the heavy rainfall season, with movements ranging from several centimeters per year. These results were consistent with numerical analyses, which showed that the potential slip surface became significantly more unstable when the water table was elevated. [ABSTRACT FROM AUTHOR]

Landslides represent a major problem in human activities, especially in the proximity of cities or infrastructure. In this paper, we present the peculiar case of Pietracamela, Italy. Pietracamela is a small village located in the Central Apennines, a few kilometers north of the Gran Sasso Mountain. The peculiarity of the case study is the fact that the village is simultaneously affected by two different types of slope instabilities. The southwest sector, representing the historical part of the village, has been affected by large rockfalls generated from the "Capo le Vene" cliff located in the south of the village. The northeastern sector of the village represents the most recent urbanized area and is involved in a deep-seated landslide that, in the last decades, has damaged buildings and infrastructure. In this context, we have used two different types of remote sensing techniques to study the two phenomena. The rockfall area has been surveyed through the use of an Unmanned Aerial Vehicle (UAV) that allowed the definition of main joint sets and the volume of blocks associated with the most recent (2011) rockfall event. Three main joint sets have been highlighted, which are responsible for the failure of the "Capo le Vene" cliff. The volume of blocks that failed during the last rock failure in 2011 ranged from a few to 1500 m3. The deep-seated landslide has been studied by analyzing borehole data and 20 years of InSAR data from ERS1/2, ENVISAT, COSMO-SkyMed, and SENTINEL-1. It has been highlighted by InSAR analysis that the northeast sector of the village shows a perfectly linear displacement trend that generates movements up to about 230 mm (about 1 cm/year). [ABSTRACT FROM AUTHOR]

Pityriasis rubra pilaris (PRP) is a rare, papulosquamous, inflammatory skin disease. PRP represents a therapeutic challenge. The rarity of this disease and its possible spontaneous remission makes the conduction and interpretation of therapeutic studies particularly difficult. Moreover, PRP not infrequently proves resistant to common topical and conventional systemic therapies. In this context, numerous biologic agents have been reported in PRP treatment. The aim of our manuscript was to review the current literature to evaluate the possible role of biologics targeting the IL17/23 axis in PRP management. Recent cases in the literature have highlighted the use of several promising drugs: IL-17 inhibitors, IL-23 inhibitors, and the IL-12/23p40 inhibitor ustekinumab. However, it should be noted that all these drugs are approved for moderate-to-severe plaque psoriasis and their use in PRP is off label. The treatment of PRP is based on clinical experience, case reports or case series reported in the literature, as randomized controlled trials are difficult to conduct due to the rarity of the condition. Despite data on the efficacy of drugs targeting IL-17 and IL-23 being promising, they are still limited. Certainly, further studies are desirable to better characterize PRP and establish shared guidelines. [ABSTRACT FROM AUTHOR]

Geotourism is a form of nature-oriented tourism devoted to the knowledge and understanding of landscape forms and geological processes; flora and fauna and cultural, historical and human heritage. The great geological and morphological variability of Avellino Province, also called Irpinia, in southern Italy makes this province of particular interest for geotourists. Irpinia has a unique set of geosites, sites of cultural interest, archaeological sites and natural parks. Additionally, since ancient times, it has been a transit route between the Tyrrhenian and Adriatic Seas and, as in all countries of the Mediterranean area, it was dominated by different races, peoples and cultures that contributed to developing its cultural identity and heritage, including its food and wine. Indeed, some Irpinian products were already known and commercialised in Roman times, including wine and olive oil. On this basis, we propose a map showing the characteristics of Avellino Province, including sites of geological, historical-archaeological and cultural value. The map will contribute to a better understanding of this province from a geotourism perspective and might guide tourists through knowledge of Irpinia. [ABSTRACT FROM AUTHOR]

Floods cause great losses in terms of human life and damages to settlements. Since the exposure is a proxy of the risk, it is essential to track flood evolution. The increasing availability of Synthetic Aperture Radar (SAR) imagery extends flood tracking capabilities because of its all-water and day/night acquisition. In this paper, in order to contribute to a better evaluation of the potential of Sentinel-1 SAR imagery to track floods, we analyzed a multi-pulse flood caused by a typhoon in the Camarines Sur Province of Philippines between the end of 2018 and the beginning of 2019. Multiple simple classification methods were used to track the spatial and temporal evolution of the flooded area. Our analysis indicates that Valley Emphasis based manual threshold identification, Otsu methodology, and K-Means Clustering have the potential to be used for tracking large and long-lasting floods, providing similar results. Because of its simplicity, the K-Means Clustering algorithm has the potential to be used in fully automated operational flood monitoring, also because of its good performance in terms of computation time. [ABSTRACT FROM AUTHOR]

In October 2015, two intense rainfall events hit the central and southern regions of Italy and triggered a combination of different and widespread effects, including floods, landslides, and soil erosion. These outcomes devastated about 68 municipalities of the Benevento province (Campania region), killed two people, and caused millions of euros worth of damage to structures, infrastructures, and agriculture. The town of Benevento was one of the sectors most affected by overflow. Extensive areas characterized by flyschoid outcrops experienced widespread occurrences of soil erosion and landslides, and destructive, high-velocity debris flows (about 50) afflicted areas that had experienced heavy rainfall of higher intensity (total rainfall of 415.6 mm). In this study, the characteristics of these rainfall events and related geomorphological processes were determined by (i) analyzing the available rainfall data to identify the spatial pattern, distribution, and statistical characteristics of the two storms and (ii) mapping the storm effects, such as flooded areas, landslide types, and soil erosion. These effects were then related to the spatial distribution of the storms and the local geological and geomorphologic settings that drove their initiation and development. [ABSTRACT FROM AUTHOR]

In this work, a low-cost, open-source and replicable system prototype for thermal analysis of low-cost Micro Electro-Mechanical Systems (MEMS) Inertial Measurement Unit (IMU) sensors in tilt measurement perspective is presented and tested. The system is formed of a 3D printed frame, a thermal cell consisting in a Peltier element mounted over a heat sink, and a control and power system. The frame is designed to allow the independent biaxial tilting of the thermal cell through two servomotors. The control board is formed by an Arduino® and a self-made board including a power drive for controlling the thermal unit and servomotors. We tested the chamber analyzing the behavior of multiple MEMS IMU onboard accelerometers suitable for measuring tilt. Our results underline the variability of the thermal behavior of the sensors, also for different sensor boards of the same model, and consequently the need for the adoption of a thermal compensation strategy based on thermal analysis results. These data suggesting the need for the analysis of the thermal behavior of MEMS-based sensors, indicate the potential of our system in making low-cost sensors suitable in medium-to-high precision monitoring applications. [ABSTRACT FROM AUTHOR]

This paper proposes a simplified GIS-based procedure which aims to preliminary assess areas exposed to debris flows by evaluating erosion and deposition area into channels and along alluvial fans. The methodology is based on the definition of several morphometric parameters on Digital Elevation Models (DEMs); it is independent from landslide volume and its rheological characteristics. By solving a set of parametric equations and excluding, from time to time, the unlikely areas by means of an analysis process that uses on/off-raster masks, potential erosion and deposition areas can be identified. The procedure was applied at six intra-mountain basins upstream of the village of Paupisi, Southern Italy, which was involved in multiple debris flow events in October 2015. The model estimated that a range between 15–21% of the selected basin drainage channels may be identified as erosion areas. Moreover, comparison of the recent debris flow paths with model outputs shows a good performance of the procedure, which was able to predict about 46% of the total actual propagation and invasion areas and about 62% of the distribution deposit areas. The methodology can be considered a useful screening for the identification of debris flow-susceptible channels, suitable for use in preliminary hazard evaluations. [ABSTRACT FROM AUTHOR]