201. Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C
- Author
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Ponziani, Fr, Viganò, R, Iemmolo, Rm, Donato, Mf, Rendina, M, Toniutto, P, Pasulo, L, Morelli, Mc, Burra, Patrizia, Miglioresi, L, Merli, M, Di Paolo, D, Fagiuoli, S, Gasbarrini, A, Pompili, M, Belli, L, Gerunda, Ge, Marino, M, Montalti, R, Di Benedetto, F, De Ruvo, N, Rigamonti, C, Colombo, M, Rossi, G, Di Leo, A, Lupo, L, Memeo, V, Bringiotti, R, Zappimbulso, M, Bitetto, D, Vero, V, Colpani, M, Fornasiere, E, Pinna, Ad, Bertuzzo, V, DE MARTIN, Eleonora, Senzolo, M, Ettorre, Gm, Visco Comandini, U, Antonucci, G, Angelico, M, Tisone, G, Giannelli, V, Giusto, M, Group, AISF RECOLT C., Ponziani, Francesca Romana, Viganò, Raffaella, Iemmolo, Rosa Maria, Donato, Maria Francesca, Rendina, Maria, Toniutto, Pierluigi, Pasulo, Luisa, Morelli, Maria Cristina, Burra, Patrizia, Miglioresi, Lucia, Merli, Manuela, Di Paolo, Daniele, Fagiuoli, Stefano, Gasbarrini, Antonio, Pompili, Maurizio, Belli, L, Gerunda, G E, Marino, M, Montalti, R, Di Benedetto, F, De Ruvo, N, Rigamonti, C, Colombo, M, Rossi, G, Di Leo, A, Lupo, L, Memeo, V, Bringiotti, R, Zappimbulso, M, Bitetto, D, Vero, V, Colpani, M, Fornasiere, E, Pinna, A D, Morelli, M C, Bertuzzo, V, De Martin, E, Senzolo, M, Ettorre, G M, Visco-Comandini, U, Antonucci, G, Angelico, M, Tisone, G, Giannelli, V, Giusto, M, Ponziani, F, Fagiuoli, S, Gasbarrini, A, Pompili, M, Francesca Romana Ponziani, Raffaella Viganò, Rosa Maria Iemmolo, Maria Francesca Donato, Maria Rendina, Pierluigi Toniutto, Luisa Pasulo, Maria Cristina Morelli, Patrizia Burra, Lucia Miglioresi, Manuela Merli, Daniele Di Paolo, Stefano Fagiuoli, Antonio Gasbarrini, Maurizio Pompili, L. Belli, G.E. Gerunda, M. Marino, R. Montalti, F. Di Benedetto, N. De Ruvo, C. Rigamonti, M. Colombo, G. Rossi, A. Di Leo, L. Lupo, V. Memeo, R. Bringiotti, M. Zappimbulso, D. Bitetto, V. Vero, M. Colpani, E. Fornasiere, A.D. Pinna, M.C. Morelli, V. Bertuzzo, E. De Martin, M. Senzolo, G.M. Ettorre, U. Visco-Comandini, G. Antonucci, M. Angelico, G. Tisone, V. Giannelli, and M. Giusto
- Subjects
Male ,Sustained viral response ,Time Factors ,medicine.medical_treatment ,Hepacivirus ,Liver transplantation ,medicine.disease_cause ,Gastroenterology ,Polyethylene Glycol ,Polyethylene Glycols ,Virological response ,HCV antiviral treatment ,Recurrence ,Retrospective Studie ,antiviral therapy ,Viral ,Recurrent hepatitis ,Chronic ,hepatitis c ,Univariate analysis ,Graft Survival ,Hepatitis C recurrence ,Long term maintenance ,Hepatitis C ,Middle Aged ,Recombinant Protein ,Recombinant Proteins ,Survival Rate ,Combination ,RNA, Viral ,Drug Therapy, Combination ,Female ,Human ,medicine.medical_specialty ,Genotype ,Time Factor ,Hepatitis C virus ,Settore MED/12 - GASTROENTEROLOGIA ,Antiviral Agents ,liver transplantation ,hepatitis c recurrence ,sustained viral response ,hcv antiviral treatment ,Follow-Up Studie ,Maintenance Chemotherapy ,Drug Therapy ,Internal medicine ,Ribavirin ,medicine ,Follow-Up Studies ,Hepatitis C, Chronic ,Humans ,Interferon-alpha ,Interleukins ,Retrospective Studies ,Liver Transplantation ,Survival rate ,Antiviral Agent ,Hepaciviru ,Hepatology ,business.industry ,Interleukin ,medicine.disease ,Immunology ,HCV, virological response, liver transplant ,RNA ,Interferons ,business - Abstract
Background The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients’ survival. Aim To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11 ± 3.5 years (range, 5–24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p = 0.007), treatment duration >80% of the scheduled period (p = 0.027), and early virological response (p = 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p = 0.008). Conclusions Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.
- Published
- 2014