3,331 results on '"Force, P"'
Search Results
202. Technology in Parkinson's disease: Challenges and opportunities
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Espay, Alberto J, Bonato, Paolo, Nahab, Fatta B, Maetzler, Walter, Dean, John M, Klucken, Jochen, Eskofier, Bjoern M, Merola, Aristide, Horak, Fay, Lang, Anthony E, Reilmann, Ralf, Giuffrida, Joe, Nieuwboer, Alice, Horne, Malcolm, Little, Max A, Litvan, Irene, Simuni, Tanya, Dorsey, E Ray, Burack, Michelle A, Kubota, Ken, Kamondi, Anita, Godinho, Catarina, Daneault, Jean‐Francois, Mitsi, Georgia, Krinke, Lothar, Hausdorff, Jeffery M, Bloem, Bastiaan R, Papapetropoulos, Spyros, and Technology, on behalf of the Movement Disorders Society Task Force on
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Parkinson's Disease ,Bioengineering ,Clinical Research ,Neurodegenerative ,Aging ,Neurosciences ,Brain Disorders ,Networking and Information Technology R&D (NITRD) ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Neurological ,Biomedical Technology ,Humans ,Parkinson Disease ,digital health ,digital biomarkers ,eHealth ,Parkinson's disease ,precision medicine ,remote monitoring ,technology ,wearable technology ,Movement Disorders Society Task Force on Technology ,Clinical Sciences ,Human Movement and Sports Sciences ,Neurology & Neurosurgery - Abstract
The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.
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- 2016
203. Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement.
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US Preventive Services Task Force, Bibbins-Domingo, Kirsten, Grossman, David C, Curry, Susan J, Bauman, Linda, Davidson, Karina W, Epling, John W, García, Francisco AR, Herzstein, Jessica, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, Mangione, Carol M, Phillips, William R, Phipps, Maureen G, and Pignone, Michael P
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US Preventive Services Task Force ,Humans ,Tuberculosis ,Mass Screening ,Risk Assessment ,Adult ,Advisory Committees ,Primary Health Care ,Latent Tuberculosis ,General & Internal Medicine ,Medical and Health Sciences - Abstract
ImportanceTuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease.ObjectiveTo issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI.Evidence reviewThe USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases.FindingsThe USPSTF found adequate evidence that accurate screening tests for LTBI are available, treatment of LTBI provides a moderate health benefit in preventing progression to active disease, and the harms of screening and treatment are small. The USPSTF has moderate certainty that screening for LTBI in persons at increased risk for infection provides a moderate net benefit.Conclusions and recommendationThe USPSTF recommends screening for LTBI in populations at increased risk. (B recommendation).
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- 2016
204. 21st Century Cardio-Oncology: Identifying Cardiac Safety Signals in the Era of Personalized Medicine.
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Sheng, Calvin, Amiri-Kordestani, Laleh, Palmby, Todd, Force, Thomas, Hong, Charles, Wu, Joseph, Croce, Kevin, Kim, Geoffrey, and Moslehi, Javid
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cardio-oncology ,cardiotoxicity ,nonclinical/preclinical models - Abstract
Cardiotoxicity is a well-established complication of oncology therapies. Cardiomyopathy resulting from anthracyclines is a classic example. In the past decade, an explosion of novel cancer therapies, often targeted and more specific than traditional therapies, has revolutionized oncology therapy and dramatically changed cancer prognosis. However, some of these therapies have introduced an assortment of cardiovascular (CV) complications. At times, these devastating outcomes have only become apparent after drug approval and have limited the use of potent therapies. There is a growing need for better testing platforms, both for CV toxicity screening, as well as for elucidating mechanisms of cardiotoxicities of approved cancer therapies. This review discusses the utility of nonclinical models (in vitro, in vivo, & in silico) available and highlights recent advancements in modalities like human stem cell-derived cardiomyocytes for developing more comprehensive cardiotoxicity testing and new means of cardioprotection with targeted anticancer therapies.
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- 2016
205. Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement.
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US Preventive Services Task Force, Bibbins-Domingo, Kirsten, Grossman, David C, Curry, Susan J, Davidson, Karina W, Epling, John W, García, Francisco AR, Gillman, Matthew W, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, LeFevre, Michael, Mangione, Carol M, Owens, Douglas K, Phillips, William R, Phipps, Maureen G, Pignone, Michael P, and Siu, Albert L
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US Preventive Services Task Force ,Humans ,Cardiovascular Diseases ,Lipids ,Mass Screening ,Risk Assessment ,Adolescent ,Child ,Preventive Health Services ,Advisory Committees ,United States ,Dyslipidemias ,Hyperlipoproteinemia Type II ,Young Adult ,Asymptomatic Diseases ,Cardiovascular ,Pediatric ,Biomedical Imaging ,Atherosclerosis ,Prevention ,Clinical Research ,Health Services ,2.1 Biological and endogenous factors ,General & Internal Medicine ,Medical and Health Sciences - Abstract
ImportanceElevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults.ObjectiveTo update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults.Evidence reviewThe USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia.FindingsEvidence on the quantitative difference in diagnostic yield between universal and selective screening approaches, the effectiveness and harms of long-term treatment and the harms of screening, and the association between changes in intermediate outcomes and improvements in adult cardiovascular health outcomes are limited. Therefore, the USPSTF concludes that the balance of benefits and harms cannot be determined.Conclusions and recommendationThe USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger. (I statement).
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- 2016
206. Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement.
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US Preventive Services Task Force, Bibbins-Domingo, Kirsten, Grossman, David C, Curry, Susan J, Davidson, Karina W, Ebell, Mark, Epling, John W, García, Francisco AR, Gillman, Matthew W, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, Mangione, Carol M, Phillips, William R, Phipps, Maureen G, Pignone, Michael P, and Siu, Albert L
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US Preventive Services Task Force ,Humans ,Melanoma ,Carcinoma ,Basal Cell ,Carcinoma ,Squamous Cell ,Skin Neoplasms ,Physical Examination ,Dermatology ,Adult ,Aged ,Middle Aged ,Advisory Committees ,Primary Health Care ,Female ,Male ,Early Detection of Cancer ,Cancer ,Health Services ,Clinical Research ,Prevention ,Good Health and Well Being ,Medical and Health Sciences ,General & Internal Medicine - Abstract
ImportanceBasal and squamous cell carcinoma are the most common types of cancer in the United States and represent the vast majority of all cases of skin cancer; however, they rarely result in death or substantial morbidity, whereas melanoma skin cancer has notably higher mortality rates. In 2016, an estimated 76,400 US men and women will develop melanoma and 10,100 will die from the disease.ObjectiveTo update the 2009 US Preventive Services Task Force (USPSTF) recommendation on screening for skin cancer.Evidence reviewThe USPSTF reviewed the evidence on the effectiveness of screening for skin cancer with a clinical visual skin examination in reducing skin cancer morbidity and mortality and death from any cause; its potential harms, including any harms resulting from associated diagnostic follow-up; its test characteristics when performed by a primary care clinician vs a dermatologist; and whether its use leads to earlier detection of skin cancer compared with usual care.FindingsEvidence to assess the net benefit of screening for skin cancer with a clinical visual skin examination is limited. Direct evidence on the effectiveness of screening in reducing melanoma morbidity and mortality is limited to a single fair-quality ecologic study with important methodological limitations. Information on harms is similarly sparse. The potential for harm clearly exists, including a high rate of unnecessary biopsies, possibly resulting in cosmetic or, more rarely, functional adverse effects, and the risk of overdiagnosis and overtreatment.Conclusions and recommendationThe USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of visual skin examination by a clinician to screen for skin cancer in adults (I statement).
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- 2016
207. Screening for Colorectal Cancer US Preventive Services Task Force Recommendation Statement
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Bibbins-Domingo, Kirsten, Grossman, David C, Curry, Susan J, Davidson, Karina W, Jr, Epling John W, Garcia, Francisco AR, Gillman, Matthew W, Harper, Diane M, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, Mangione, Carol M, Owens, Douglas K, Phillips, William R, Phipps, Maureen G, Pignone, Michael P, Siu, Albert L, and Force, US Preventive Serv Task
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General & Internal Medicine ,Medical and Health Sciences - Published
- 2016
208. Screening for Syphilis Infection in Nonpregnant Adults and Adolescents: US Preventive Services Task Force Recommendation Statement.
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US Preventive Services Task Force (USPSTF), Bibbins-Domingo, Kirsten, Grossman, David C, Curry, Susan J, Davidson, Karina W, Epling, John W, García, Francisco AR, Gillman, Matthew W, Harper, Diane M, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, Mangione, Carol M, Phillips, William R, Phipps, Maureen G, and Pignone, Michael P
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US Preventive Services Task Force ,Humans ,Syphilis ,Sexually Transmitted Diseases ,Syphilis Serodiagnosis ,Risk Assessment ,Adolescent ,Adult ,Preventive Health Services ,Advisory Committees ,United States ,Female ,Asymptomatic Infections ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Prevention ,HIV/AIDS ,Rare Diseases ,Sexually Transmitted Infections ,Clinical Research ,Infectious Diseases ,2.1 Biological and endogenous factors ,Infection ,General & Internal Medicine ,Medical and Health Sciences - Abstract
ImportanceIn 2014, 19,999 cases of syphilis were reported in the United States. Left untreated, syphilis can progress to late-stage disease in about 15% of persons who are infected. Late-stage syphilis can lead to development of inflammatory lesions throughout the body, which can lead to cardiovascular or organ dysfunction. Syphilis infection also increases the risk for acquiring or transmitting HIV infection.ObjectiveTo update the 2004 US Preventive Services Task Force (USPSTF) recommendation on screening for syphilis infection in nonpregnant adults. Screening for syphilis in pregnant women was updated in a separate recommendation statement in 2009 (A recommendation).Evidence reviewThe USPSTF reviewed the evidence on screening for syphilis infection in asymptomatic, nonpregnant adults and adolescents, including patients coinfected with other sexually transmitted infections (such as HIV).FindingsThe USPSTF found convincing evidence that screening for syphilis infection in asymptomatic, nonpregnant persons at increased risk for infection provides substantial benefit. Accurate screening tests are available to identify syphilis infection in populations at increased risk. Effective treatment with antibiotics can prevent progression to late-stage disease, with small associated harms, providing an overall substantial health benefit.Conclusions and recommendationThe USPSTF recommends screening for syphilis infection in persons who are at increased risk for infection. (A recommendation).
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- 2016
209. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
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US Preventive Services Task Force, Bibbins-Domingo, Kirsten, Grossman, David C, Curry, Susan J, Davidson, Karina W, Epling, John W, García, Francisco AR, Gillman, Matthew W, Harper, Diane M, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, Mangione, Carol M, Owens, Douglas K, Phillips, William R, Phipps, Maureen G, Pignone, Michael P, and Siu, Albert L
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US Preventive Services Task Force ,Feces ,Humans ,Colorectal Neoplasms ,DNA ,Colonography ,Computed Tomographic ,Colonoscopy ,Sigmoidoscopy ,Occult Blood ,Immunohistochemistry ,Risk Assessment ,Age Factors ,Aged ,Middle Aged ,Preventive Health Services ,Advisory Committees ,United States ,Septins ,Digestive Diseases ,Cancer ,Health Services ,Clinical Research ,Colo-Rectal Cancer ,Prevention ,Aging ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,4.4 Population screening ,Good Health and Well Being ,Medical and Health Sciences ,General & Internal Medicine - Abstract
ImportanceColorectal cancer is the second leading cause of cancer death in the United States. In 2016, an estimated 134,000 persons will be diagnosed with the disease, and about 49,000 will die from it. Colorectal cancer is most frequently diagnosed among adults aged 65 to 74 years; the median age at death from colorectal cancer is 68 years.ObjectiveTo update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for colorectal cancer.Evidence reviewThe USPSTF reviewed the evidence on the effectiveness of screening with colonoscopy, flexible sigmoidoscopy, computed tomography colonography, the guaiac-based fecal occult blood test, the fecal immunochemical test, the multitargeted stool DNA test, and the methylated SEPT9 DNA test in reducing the incidence of and mortality from colorectal cancer or all-cause mortality; the harms of these screening tests; and the test performance characteristics of these tests for detecting adenomatous polyps, advanced adenomas based on size, or both, as well as colorectal cancer. The USPSTF also commissioned a comparative modeling study to provide information on optimal starting and stopping ages and screening intervals across the different available screening methods.FindingsThe USPSTF concludes with high certainty that screening for colorectal cancer in average-risk, asymptomatic adults aged 50 to 75 years is of substantial net benefit. Multiple screening strategies are available to choose from, with different levels of evidence to support their effectiveness, as well as unique advantages and limitations, although there are no empirical data to demonstrate that any of the reviewed strategies provide a greater net benefit. Screening for colorectal cancer is a substantially underused preventive health strategy in the United States.Conclusions and recommendationsThe USPSTF recommends screening for colorectal cancer starting at age 50 years and continuing until age 75 years (A recommendation). The decision to screen for colorectal cancer in adults aged 76 to 85 years should be an individual one, taking into account the patient's overall health and prior screening history (C recommendation).
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- 2016
210. Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement.
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Bibbins-Domingo, Kirsten and U.S. Preventive Services Task Force
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U.S. Preventive Services Task Force ,Humans ,Colorectal Neoplasms ,Cardiovascular Diseases ,Hemorrhage ,Aspirin ,Fibrinolytic Agents ,Anticarcinogenic Agents ,Risk Assessment ,Primary Prevention ,Adult ,Cancer ,Aging ,Heart Disease ,Prevention ,Digestive Diseases ,Colo-Rectal Cancer ,Clinical Research ,Cardiovascular ,6.1 Pharmaceuticals ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Evaluation of treatments and therapeutic interventions ,3.3 Nutrition and chemoprevention ,Good Health and Well Being ,Medical and Health Sciences ,General & Internal Medicine - Abstract
DescriptionUpdate of the 2009 USPSTF recommendation on aspirin use to prevent cardiovascular disease (CVD) events and the 2007 recommendation on aspirin and nonsteroidal anti-inflammatory drug use to prevent colorectal cancer (CRC).MethodsThe USPSTF reviewed 5 additional studies of aspirin for the primary prevention of CVD and several additional analyses of CRC follow-up data. The USPSTF also relied on commissioned systematic reviews of all-cause mortality and total cancer incidence and mortality and a comprehensive review of harms. The USPSTF then used a microsimulation model to systematically estimate the balance of benefits and harms.PopulationThis recommendation applies to adults aged 40 years or older without known CVD and without increased bleeding risk.RecommendationsThe USPSTF recommends initiating low-dose aspirin use for the primary prevention of CVD and CRC in adults aged 50 to 59 years who have a 10% or greater 10-year CVD risk, are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years. (B recommendation) The decision to initiate low-dose aspirin use for the primary prevention of CVD and CRC in adults aged 60 to 69 years who have a 10% or greater 10-year CVD risk should be an individual one. Persons who are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years are more likely to benefit. Persons who place a higher value on the potential benefits than the potential harms may choose to initiate low-dose aspirin. (C recommendation) The current evidence is insufficient to assess the balance of benefits and harms of initiating aspirin use for the primary prevention of CVD and CRC in adults younger than 50 years. (I statement) The current evidence is insufficient to assess the balance of benefits and harms of initiating aspirin use for the primary prevention of CVD and CRC in adults aged 70 years or older. (I statement).
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- 2016
211. Screening for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Recommendation Statement.
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US Preventive Services Task Force (USPSTF), Siu, Albert L, Bibbins-Domingo, Kirsten, Grossman, David C, Davidson, Karina W, Epling, John W, García, Francisco AR, Gillman, Matthew, Kemper, Alex R, Krist, Alex H, Kurth, Ann E, Landefeld, C Seth, Mangione, Carol M, Harper, Diane M, Phillips, William R, Phipps, Maureen G, and Pignone, Michael P
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US Preventive Services Task Force ,Humans ,Pulmonary Disease ,Chronic Obstructive ,Spirometry ,Early Diagnosis ,Risk Assessment ,Smoking Cessation ,Health Status ,Quality of Life ,Adult ,Aged ,Middle Aged ,Advisory Committees ,United States ,Asymptomatic Diseases ,Surveys and Questionnaires ,Pulmonary Disease ,Chronic Obstructive ,Prevention ,Chronic Obstructive Pulmonary Disease ,Health Services ,Clinical Research ,Lung ,4.2 Evaluation of markers and technologies ,4.4 Population screening ,Respiratory ,General & Internal Medicine ,Medical and Health Sciences - Abstract
ImportanceAbout 14% of US adults aged 40 to 79 years have chronic obstructive pulmonary disease (COPD), and it is the third leading cause of death in the United States. Persons with severe COPD are often unable to participate in normal physical activity due to deterioration of lung function.ObjectiveTo update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for COPD in asymptomatic adults.Evidence reviewThe USPSTF reviewed the evidence on whether screening for COPD in asymptomatic adults (those who do not recognize or report respiratory symptoms) improves health outcomes. The USPSTF reviewed the diagnostic accuracy of screening tools (including prescreening questionnaires and spirometry); whether screening for COPD improves the delivery and uptake of targeted preventive services, such as smoking cessation or relevant immunizations; and the possible harms of screening for and treatment of mild to moderate COPD.FindingsSimilar to 2008, the USPSTF did not find evidence that screening for COPD in asymptomatic persons improves health-related quality of life, morbidity, or mortality. The USPSTF determined that early detection of COPD, before the development of symptoms, does not alter the course of the disease or improve patient outcomes. The USPSTF concludes with moderate certainty that screening for COPD in asymptomatic persons has no net benefit.Conclusions and recommendationThe USPSTF recommends against screening for COPD in asymptomatic adults. (D recommendation).
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- 2016
212. Performance of the Caltech Submillimeter Observatory Dual-Color 180-720 GHz Balanced SIS Receivers
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Kooi, J. W., Chamberlin, R. A., Monje, R., Kovacs, A., Rice, F., Yoshida, H., Force, B., Cooper, K., Miller, D., Gould, M., Lis, D., Bumble, B., LeDuc, R., Stern, J. A., and Phillips, T. G.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We report on balanced SIS receivers covering the astronomical important 180-720 GHz submillimeter atmospheric window. To facilitate remote observations and automated spectral line surveys, fully synthesized local oscillators are employed. High-current-density Nb-AlN-Nb superconducting-insulating-superconducting (SIS) tunnel junctions are used as the mixing element. The measured double-sideband (DSB) 230 GHz receiver noise temperature, uncorrected for optics loss, ranges from 50K at 185 GHz, 33K at 246 GHz, to 51K at 280 GHz. In this frequency range the mixer has a DSB conversion gain of 0 +- 1.5 dB. The measured 460 GHz double-sideband receiver noise temperature, uncorrected for optics loss, is 32K at 400 GHz, 34K at 460 GHz, and 61K at 520 GHz. Similar to the 230 GHz balanced mixer, the DSB mixer conversion gain is 1 +- 1 dB. To help optimize performance, the mixer IF circuits and bias injection are entirely planar by design. Dual-frequency observation, by means of separating the incoming circular polarized electric field into two orthogonal components, is another important mode of operation offered by the new facility instrumentation. Instrumental stability is excellent supporting the LO noise cancellation properties of the balanced mixer configuration. In the spring of 2012 the dual-frequency 230/460 SIS receiver was successfully installed at Caltech Submillimeter Observatory (CSO), Mauna Kea, HI., Comment: Accepted for publication in IEEE/TST
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- 2014
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213. In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs
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Li, Jibin, Bukhtiyarov, Yuri, Spivey, Nicole, Force, Christopher, Hidalgo, Carlos, Huang, Yuehua, Owen, Albert J., and Hidalgo, Ismael J.
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- 2020
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214. Surgery for Men with Breast Cancer: Do the Same Data Still Apply?
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Plichta, Jennifer K., Ren, Yi, Marks, Caitlin E., Thomas, Samantha M., Greenup, Rachel A., Rosenberger, Laura H., Fayanju, Oluwadamilola M., McDuff, Susan G. R., Hwang, E. Shelley, and Force, Jeremy
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- 2020
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215. A multi-center naturalistic study of a newly designed 12-sessions group psychoeducation program for patients with bipolar disorder and their caregivers
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Susan Zyto, Nienke Jabben, Peter F. J. Schulte, Eline J. Regeer, Peter J. J. Goossens, Ralph W. Kupka, and the Task Force Psychotherapy of the Dutch Foundation for Bipolar Disorders
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Bipolar disorder ,Psychoeducation ,Self-management ,Expressed emotions ,Caregivers ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Abstract Background Psychoeducation (PE) for bipolar disorder (BD) has a first-line recommendation for the maintenance treatment phase of BD. Formats vary greatly in the number of sessions, whether offered individually or in a group, and with or without caregivers attending. Due to a large variation in formats in the Netherlands, a new program was developed and implemented in 17 outpatient clinics throughout the country. The current study investigated the feasibility of a newly developed 12-sessions PE group program for patients with BD and their caregivers in routine outpatient practice and additionally explored its effectiveness. Methods Participants in the study were 108 patients diagnosed with BD, 88 caregivers and 35 course leaders. Feasibility and acceptance of the program were investigated by measures of attendance, and evaluative questionnaires after session 12. Preliminary treatment effects were investigated by pre- and post-measures on mood symptoms, attitudes towards BD and its treatment, levels of self-management, and levels of expressed emotion. Results There was a high degree of satisfaction with the current program as reported by patients, caregivers, and course leaders. The average attendance was high and 83% of the patients and 75% of the caregivers completed the program. Analyses of treatment effects suggest positive effects on depressive symptoms and self-management in patients, and lower EE as experienced by caregivers. Conclusions This compact 12-sessions psychoeducation group program showed good feasibility and was well accepted by patients, caregivers, and course leaders. Preliminary effects on measures of self-management, expressed emotions, and depressive symptoms were promising. After its introduction it has been widely implemented in mental health institutions throughout the Netherlands.
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- 2020
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216. Effects of hypertonic saline versus mannitol in patients with traumatic brain injury in prehospital, emergency department, and intensive care unit settings: a systematic review and meta-analysis
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Yukari Miyoshi, Yutaka Kondo, Hidetaka Suzuki, Tatsuma Fukuda, Hideto Yasuda, Shoji Yokobori, and for the Japan Resuscitation Council (JRC) Neuroresuscitation Task Force and the Guidelines Editorial Committee
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Traumatic brain injury ,Hypertonic saline ,Mannitol ,Prognosis ,Trauma ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Intracranial pressure control has long been recognized as an important requirement for patients with severe traumatic brain injury. Hypertonic saline has drawn attention as an alternative to mannitol in this setting. The aim of this study was to assess the effects of hypertonic saline versus mannitol on clinical outcomes in patients with traumatic brain injury in prehospital, emergency department, and intensive care unit settings by systematically reviewing the literature and synthesizing the evidence from randomized controlled trials. Methods We searched the MEDLINE database, the Cochrane Central Register of Controlled Trials, and the Igaku Chuo Zasshi (ICHUSHI) Web database with no date restrictions. We selected randomized controlled trials in which the clinical outcomes of adult patients with traumatic brain injury were compared between hypertonic saline and mannitol strategies. Two investigators independently screened the search results and conducted the data extraction. The primary outcome was all-cause mortality. The secondary outcomes were 90-day and 180-day mortality, good neurological outcomes, reduction in intracranial pressure, and serum sodium level. Random effects estimators with weights calculated by the inverse variance method were used to determine the pooled risk ratios. Results A total of 125 patients from four randomized trials were included, and all the studies were conducted in the intensive care unit. Among 105 patients from three trials that evaluated the primary outcome, 50 patients were assigned to the hypertonic saline group and 55 patients were assigned to the mannitol group. During the observation period, death was observed for 16 patients in the hypertonic saline group (32.0%) and 21 patients in the mannitol group (38.2%). The risks were not significant between the two infusion strategies (pooled risk ratio, 0.82; 95% confidence interval, 0.49–1.37). There were also no significant differences between the two groups in the other secondary outcomes. However, the certainty of the evidence was rated very low for all outcomes. Conclusions Our findings revealed no significant difference in the all-cause mortality rates between patients receiving hypertonic saline or mannitol to control intracranial pressure. Further investigation is warranted because we only included a limited number of studies
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- 2020
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217. Consensus statement on coronary intervention during the coronavirus disease 19 pandemic: from the Korean Society of Interventional Cardiology
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Kwan Yong Lee, Bong-Ki Lee, Won-Jang Kim, Se Hun Kang, Taek Kyu Park, Song-Yi Kim, Jung-Won Suh, Chang-Hwan Yoon, Dong Heon Yang, Sung Kee Ryu, Sang-Hyun Kim, Sung Yun Lee, In-Ho Chae, and The Korean Society of Interventional Cardiology COVID-19 Task Force Team
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covid-19 ,cardiovascular diseases ,coronary angiography ,percutaneous coronary intervention ,practice guideline ,Medicine - Abstract
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus 2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is also causing serious health problems in the area of cardiovascular intervention. In response, the Korean Society of Interventional Cardiology formed a COVID-19 task force to develop practice guidelines. This special article introduces clinical practice guidelines to prevent secondary transmission of COVID-19 within facilities; the guidelines were developed to protect patients and healthcare workers from this highly contagious virus. We hope these guidelines help healthcare workers and cardiovascular disease patients around the world cope with the COVID-19 pandemic.
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- 2020
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218. Efficacy and safety of tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis
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Shoji Yokobori, Tomoaki Yatabe, Yutaka Kondo, Kosaku Kinoshita, and for the Japan Resuscitation Council (JRC) Neuroresuscitation Task Force and the Guidelines Editorial Committee
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Clotting ,TBI ,Head-trauma ,Hemorrhage ,Fibrinolysis ,Hematoma ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The exacerbation of intracranial bleeding is critical in traumatic brain injury (TBI) patients. Tranexamic acid (TXA) has been used to improve outcomes in TBI patient. However, the effectiveness of TXA treatment remains unclear. This study aimed to assess the effect of administration of TXA on clinical outcomes in patients with TBI by systematically reviewing the literature and synthesizing evidence of randomized controlled trials (RCTs). Methods MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI) Web were searched. Selection criteria included randomized controlled trials with clinical outcomes of adult TBI patients administered TXA or placebo within 24 h after admission. Two investigators independently screened citations and conducted data extraction. The primary “critical” outcome was all-cause mortality. The secondary “important” outcomes were good neurological outcome rates, enlargement of bleeding, incidence of ischemia, and hemorrhagic intracranial complications. Random effect estimators with weights calculated by the inverse variance method were used to report risk ratios (RRs). Results A total of 640 records were screened. Seven studies were included for quantitative analysis. Of 10,044 patients from seven of the included studies, 5076 were randomly assigned to the TXA treatment group, and 4968 were assigned to placebo. In the TXA treatment group, 914 patients (18.0%) died, while 961 patients (19.3%) died in the placebo group. There was no significant difference between groups (RR, 0.93; 95% confidence interval, 0.86–1.01). No significant differences between the groups in other important outcomes were also observed. Conclusions TXA treatment demonstrated a tendency to reduce head trauma-related deaths in the TBI population, with no significant incidence of thromboembolic events. TXA treatment may therefore be suggested in the initial TBI care.
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- 2020
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219. Consensus statement of the Italian society of pediatric allergy and immunology for the pragmatic management of children and adolescents with allergic or immunological diseases during the COVID-19 pandemic
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Fabio Cardinale, Giorgio Ciprandi, Salvatore Barberi, Roberto Bernardini, Carlo Caffarelli, Mauro Calvani, Giovanni Cavagni, Elena Galli, Domenico Minasi, Michele Miraglia del Giudice, Viviana Moschese, Elio Novembre, Francesco Paravati, Diego G. Peroni, Maria Angela Tosca, Giovanni Traina, Salvatore Tripodi, Gian Luigi Marseglia, and and the SIAIP Task Force
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COVID-19 ,Pandemic ,Child ,Adolescent ,Allergy ,Asthma ,Pediatrics ,RJ1-570 - Abstract
Abstract The COVID-19 pandemic has surprised the entire population. The world has had to face an unprecedented pandemic. Only, Spanish flu had similar disastrous consequences. As a result, drastic measures (lockdown) have been adopted worldwide. Healthcare service has been overwhelmed by the extraordinary influx of patients, often requiring high intensity of care. Mortality has been associated with severe comorbidities, including chronic diseases. Patients with frailty were, therefore, the victim of the SARS-COV-2 infection. Allergy and asthma are the most prevalent chronic disorders in children and adolescents, so they need careful attention and, if necessary, an adaptation of their regular treatment plans. Fortunately, at present, young people are less suffering from COVID-19, both as incidence and severity. However, any age, including infancy, could be affected by the pandemic. Based on this background, the Italian Society of Pediatric Allergy and Immunology has felt it necessary to provide a Consensus Statement. This expert panel consensus document offers a rationale to help guide decision-making in the management of children and adolescents with allergic or immunologic diseases.
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- 2020
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220. Korean clinical practice guidelines for preventing transmission of coronavirus disease 2019 (COVID-19) in hemodialysis facilities
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Hayne Cho Park, Do Hyoung Kim, Kyung Don Yoo, Yang-Gyun Kim, Sang-Ho Lee, Hye Eun Yoon, Dong Ki Kim, Seong Nam Kim, Myeong Sung Kim, Yoon Chul Jung, Yon Su Kim, Young-Ki Lee, and The Korean Society of Nephrology COVID-19 Task Force Team
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covid-19 ,hemodialysis units ,infection control ,practice guideline ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Coronavirus disease 2019 (COVID-19) is a highly contagious viral disease that is caused by the novel virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). COVID-19 has become pandemic since December 2019, when the first case developed in Wuhan, China. Patients receiving hemodialysis are more vulnerable to viral transmission because their immune functions are impaired and they receive treatment within a narrow space. Calling on previous experience with Middle East Respiratory Syndrome during the 2015 outbreak, the joint committee of the Korean Society of Nephrology and the Korean Society of Dialysis Therapy quickly formed a COVID-19 task force team to develop a manual before the first index case was diagnosed in the hemodialysis unit. This special article introduces clinical practice guidelines to prevent secondary transmission of COVID-19 within hemodialysis facilities, which were developed to protect patients, healthcare workers, and caregivers from this highly transmissible virus. The areas of infection control covered by these guidelines include standard precautions, performing dialysis therapy for confirmed or suspected cases, performing cohort isolation for contact patients, and disease monitoring and contact surveillance. We hope these guidelines help healthcare workers and hemodialysis patients around the world cope with the COVID-19 pandemic.
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- 2020
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221. Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
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Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song, and on behalf of the Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association
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diabetes ,neoplasms ,korean national health insurance service system ,Medicine - Abstract
Background/Aims We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ-specific cancer risk according to the duration of diabetes. Methods Using a database provided by the Korean National Health Insurance Service, we conducted a retrospective, population-based cohort study of adults aged ≥ 30 years from January 2005 to December 2013. To verify the possibility of detection bias or reverse causation, we compared hazard ratios (HRs) for each cancer according to the following duration of diabetes: less than 6 months, 6 months to 3 years, and more than 3 years. Results The incidence of overall cancer per 1,000 person-years was higher in patients with diabetes than in those without diabetes (20.36 vs. 10.83). The overall cancer risk according to the duration of diabetes was the highest within the first 6 months after diagnosis (HR, 2.03; 95% confidence interval [CI], 1.99 to 2.07), and the HR decreased with the duration of diabetes, ranging from 1.19 (95% CI, 1.18 to 1.21) between 6 months and 3 years to 1.12 (95% CI, 1.11 to 1.13) after 3 years. Both overall cancer risk and HR remained significantly higher in patients with diabetes than in those without diabetes. The risk for prostate cancer was higher in men with diabetes than in those without diabetes (HR, 1.12; 95% CI, 1.10 to 1.14). In women, the risk for endometrial cancer was significantly higher in patients with diabetes than in those without diabetes throughout the duration of diabetes. Conclusions The risk for stomach, colorectum, liver, pancreas, and kidney cancer appeared to be higher in patients with diabetes than in those without diabetes regardless of the sex or duration of diabetes.
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- 2020
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222. How to develop a national heart failure clinics network: a consensus document of the Hellenic Heart Failure Association
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The Task force of the Hellenic Heart Failure Clinics Network
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Heart failure ,Heart failure clinics ,Heart failure network ,Multidisciplinary team ,Discharge letter ,Electronic health care record ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Heart failure (HF) is rapidly growing, conferring considerable mortality, morbidity, and costs. Dedicated HF clinics improve patient outcomes, and the development of a national HF clinics network aims at addressing this need at national level. Such a network should respect the existing health care infrastructures, and according to the capacities of hosting facilities, it can be organized into three levels. Establishing the continuous communication and interaction among the components of the network is crucial, while supportive actions that can enhance its efficiency include involvement of multidisciplinary health care professionals, use of structured HF‐specific documents, such as discharge notes, patient information leaflets, and patient booklets, and implementation of an HF‐specific electronic health care record and database platform.
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- 2020
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223. Pelvic floor rehabilitation to improve functional outcome and quality of life after surgery for rectal cancer: study protocol for a randomized controlled trial (FORCE trial)
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A.J. Kalkdijk-Dijkstra, J.A.G. van der Heijden, H.L. van Westreenen, P.M.A. Broens, M. Trzpis, J.P.E.N. Pierie, B.R. Klarenbeek, and FORCE Trial Group
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Quality of life, Fecal incontinence, Low anterior resection, Pelvic floor rehabilitation, Functional outcomes, Low anterior resection syndrome, Rectal cancer ,Medicine (General) ,R5-920 - Abstract
Abstract Background After low anterior resection (LAR), up to 90% of patients develop anorectal dysfunction. Especially fecal incontinence has a major impact on the physical, psychological, social, and emotional functioning of the patient but also on the Dutch National Healthcare budget with more than €2000 spent per patient per year. No standardized treatment is available to help these patients. Common treatment nowadays is focused on symptom relief, consisting of lifestyle advices and pharmacotherapy with bulking agents or antidiarrheal medication. Another possibility is pelvic floor rehabilitation (PFR), which is one of the most important treatments for fecal incontinence in general, with success rates of 50–80%. No strong evidence is available for the use of PFR after LAR. This study aims to prove a beneficial effect of PFR on fecal incontinence, quality of life, and costs in rectal cancer patients after sphincter-saving surgery compared to standard treatment. Methods The FORCE trial is a multicenter, two-armed, randomized clinical trial. All patients that underwent LAR are recruited from the participating hospitals and randomized for either standard treatment or a standardized PFR program. A total of 128 patients should be randomized. Optimal blinding is not possible. Stratification will be done in variable blocks (gender and additional radiotherapy). The primary endpoint is the Wexner incontinence score; secondary endpoints are health-related and fecal-incontinence-related QoL and cost-effectiveness. Baseline measurements take place before randomization. The primary endpoint is measured 3 months after the start of the intervention, with a 1-year follow-up for sustainability research purposes. Discussion The results of this study may substantially improve postoperative care for patients with fecal incontinence or anorectal dysfunction after LAR. This section provides insight in the decisions that were made in the organization of this trial. Trial registration Netherlands Trial Registration, NTR5469, registered on 03-09-2015. Protocol FORCE trial V18, 19-09-2019. Sponsor Radboud University Medical Center, Nijmegen.
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- 2020
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224. Program planning in education and light exercise training for atrial fibrillation patients: A feasibility study
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Connor Tripp, Zachary Force, Nichelle L Huber, J Paul Mounsey, Aditi Naniwadekar, Rajasekhar Nekkanti, and Samuel F Sears
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atrial fibrillation ,patient education ,physical activity ,psychological distress ,self-care ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Contemporary management of patients with atrial fibrillation (AF) indicates the need for educational and self-care programs to address lifestyle factors. Aims: This study examined the clinical need and interest in programming for risk factor modification in AF patients residing in a mostly rural area. Methods: Participants with AF (n = 86) were recruited during university-based cardiac electrophysiology appointments and asked to complete a 10-min survey battery assessing a range of risk factors spanning physical activity, knowledge, ability, interest, and engagement, as well as psychologic function. Results: AF risk factor reports indicated broad potential need for AF programming with an average CHADS-VASC of 3.8, with approximately 67% reporting low physical activity, and 38% significant anxiety. Related to self-care topics, education on physical activity was the highest-rated program, but weight-loss programming was rated as the most likely to attend. Distance to the clinic was the most often cited barrier, 50% of sample. Conclusions: AF patients demonstrated a need and view educational programming in the realm of physical activity and weight-loss as desirable. Increased research is needed to determine format and duration of treatment deemed efficacious and able to overcome specific barriers such as distance to care.
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- 2020
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225. IgG and IgM antibody formation to spike and nucleocapsid proteins in COVID-19 characterized by multiplex immunoblot assays
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Shah, Jyotsna, Liu, Song, Potula, Hari-Hara, Bhargava, Prerna, Cruz, Iris, Force, Denise, Bazerbashi, Ammar, and Ramasamy, Ranjan
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- 2021
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226. The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases – recommendations of the IRDiRC Data Mining and Repurposing Task Force
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Noel T Southall, Madhusudan Natarajan, Lilian Pek Lian Lau, Anneliene Hechtelt Jonker, Benoît Deprez, Tim Guilliams, Lawrence Hunter, Carin MA Rademaker, Virginie Hivert, Diego Ardigò, and on behalf of the IRDiRC Data Mining and Repurposing Task Force
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Rare disease ,Data mining ,Repurposing ,Repositioning ,Therapies ,Drug development ,Medicine - Abstract
Abstract The number of available therapies for rare diseases remains low, as fewer than 6% of rare diseases have an approved treatment option. The International Rare Diseases Research Consortium (IRDiRC) set up the multi-stakeholder Data Mining and Repurposing (DMR) Task Force to examine the potential of applying biomedical data mining strategies to identify new opportunities to use existing pharmaceutical compounds in new ways and to accelerate the pace of drug development for rare disease patients. In reviewing past successes of data mining for drug repurposing, and planning for future biomedical research capacity, the DMR Task Force identified four strategic infrastructure investment areas to focus on in order to accelerate rare disease research productivity and drug development: (1) improving the capture and sharing of self-reported patient data, (2) better integration of existing research data, (3) increasing experimental testing capacity, and (4) sharing of rare disease research and development expertise. Additionally, the DMR Task Force also recommended a number of strategies to increase data mining and repurposing opportunities for rare diseases research as well as the development of individualized and precision medicine strategies.
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- 2019
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227. Epidemiology and Outcome of Sepsis in Adults and Children in a Rural, Sub-Sahara African Setting
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Arthur Kwizera, MD, Olivier Urayeneza, MD, FACS, Pierre Mujyarugamba, MSc, Inipavudu Baelani, PhD, Jens Meier, MD, Mervyn Mer, MD, Ndidiamaka Musa, MD, Niranjan Kissoon, MD, FCCM, Andrew J. Patterson, MD, PhD, Joseph C. Farmer, MD, FCCM, Martin W. Dünser, MD, and For the “Sepsis in Resource-Limited Nations” Task Force of the Surviving Sepsis Campaign
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
OBJECTIVES:. To identify the epidemiology and outcome of adults and children with and without sepsis in a rural sub-Sahara African setting. DESIGN:. A priori planned substudy of a prospective, before-and-after trial. SETTING:. Rural, sub-Sahara African hospital. PATIENTS:. One-thousand four-hundred twelve patients (adults, n = 491; children, n = 921) who were admitted to hospital because of an acute infection. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Demographic, clinical, laboratory data, danger signs, and the presence of sepsis (defined as a quick Sequential Organ Failure Assessment score count ≥ 2) at admission were extracted. Sepsis was observed in 69 adults (14.1%) and 248 children (26.9%). Sepsis patients differed from subjects without sepsis in several demographic and clinical aspects. Malaria was the most frequent type of infection in adults (66.7%) and children (63.7%) with sepsis, followed by suspected bacterial and parasitic infections other than malaria. Adults with sepsis more frequently developed respiratory failure (8.7% vs 2.1%; p = 0.01), had a higher in-hospital mortality (17.4% vs 8.3%; p < 0.001), were less often discharged home (81.2% vs 92.2%; p = 0.007), and had higher median (interquartile range) costs of care (30,300 [19,400–49,900] vs 42,500 Rwandan Francs [27,000–64,400 Rwandan Francs]; p = 0.004) than adults without sepsis. Children with sepsis were less frequently discharged home than children without sepsis (93.1% vs 96.4%; p = 0.046). Malaria and respiratory tract infections claimed the highest absolute numbers of lives. The duration of symptoms before hospital admission did not differ between survivors and nonsurvivors in adults (72 [24–168] vs 96 hr [72–168 hr]; p = 0.27) or children (48 [24–72] vs 36 [24–108 hr]; p = 0.8). Respiratory failure and coma were the most common causes of in-hospital death. CONCLUSIONS:. In addition to suspected bacterial, viral, and fungal infections, malaria and other parasitic infections are common and important causes of sepsis in adults and children admitted to a rural hospital in sub-Sahara Africa. The in-hospital mortality associated with sepsis is substantial, primarily in adults.
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- 2021
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228. Characterization of Helianthus annuus Lipoic Acid Biosynthesis: The Mitochondrial Octanoyltransferase and Lipoyl Synthase Enzyme System
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Raquel Martins-Noguerol, Sébastien Acket, M. Adrián Troncoso-Ponce, Rafael Garcés, Brigitte Thomasset, Mónica Venegas-Calerón, Joaquín J. Salas, Enrique Martínez-Force, and Antonio J. Moreno-Pérez
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sunflower ,octanoyltransferase ,lipoyl synthase ,lipoic acid ,mitochondrial lipoylation ,Plant culture ,SB1-1110 - Abstract
Lipoic acid (LA, 6,8-dithiooctanoic acid) is a sulfur containing coenzyme essential for the activity of several key enzymes involved in oxidative and single carbon metabolism in most bacteria and eukaryotes. LA is synthetized by the concerted activity of the octanoyltransferase (LIP2, EC 2.3.1.181) and lipoyl synthase (LIP1, EC 2.8.1.8) enzymes. In plants, pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase or glycine decarboxylase are essential complexes that need to be lipoylated. These lipoylated enzymes and complexes are located in the mitochondria, while PDH is also present in plastids where it provides acetyl-CoA for de novo fatty acid biosynthesis. As such, lipoylation of PDH could regulate fatty acid synthesis in both these organelles. In the present work, the sunflower LIP1 and LIP2 genes (HaLIP1m and HaLIP2m) were isolated sequenced, cloned, and characterized, evaluating their putative mitochondrial location. The expression of these genes was studied in different tissues and protein docking was modeled. The genes were also expressed in Escherichia coli and Arabidopsis thaliana, where their impact on fatty acid and glycerolipid composition was assessed. Lipidomic studies in Arabidopsis revealed lipid remodeling in lines overexpressing these enzymes and the involvement of both sunflower proteins in the phenotypes observed is discussed in the light of the results obtained.
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- 2021
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229. Tele-Neurorehabilitation During the COVID-19 Pandemic: Implications for Practice in Low- and Middle-Income Countries
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Abhishek Srivastava, Aishwarya Swaminathan, Manigandan Chockalingam, Murali K. Srinivasan, Nirmal Surya, Partha Ray, Prasanna S. Hegde, Preetie Shetty Akkunje, Sanjivani Kamble, Sonal Chitnis, Sureshkumar Kamalakannan, Suvarna Ganvir, Urvashi Shah, and The Indian Federation of Neurorehabilitation (IFNR) Research Task Force
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neurorehabilitation ,tele-rehabilitation system ,neurological disability ,COVID-19 ,pandemic (COVID-19) ,low- and middle-income countries ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
The importance of neurorehabilitation services for people with disabilities is getting well-recognized in low- and middle-income countries (LMICs) recently. However, accessibility to the same has remained the most significant challenge, in these contexts. This is especially because of the non-availability of trained specialists and the availability of neurorehabilitation centers only in urban cities owned predominantly by private healthcare organizations. In the current COVID-19 pandemic, the members of the Task Force for research at the Indian Federation of Neurorehabilitation (IFNR) reviewed the context for tele-neurorehabilitation (TNR) and have provided the contemporary implications for practicing TNR during COVID-19 for people with neurological disabilities (PWNDs) in LMICs. Neurorehabilitation is a science that is driven by rigorous research-based evidence. The current pandemic implies the need for systematically developed TNR interventions that is evaluated for its feasibility and acceptability and that is informed by available evidence from LMICs. Given the lack of organized systems in place for the provision of neurorehabilitation services in general, there needs to be sufficient budgetary allocations and a sector-wide approach to developing policies and systems for the provision of TNR services for PWNDs. The pandemic situation provides an opportunity to optimize the technological innovations in health and scale up these innovations to meet the growing burden of neurological disability in LMICs. Thus, this immense opportunity must be tapped to build capacity for safe and effective TNR services provision for PWNDs in these settings.
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- 2021
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230. A case study of the feasibility of weekly tACS for the treatment of auditory hallucinations in schizophrenia
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Rachel B. Force, Justin Riddle, L. Fredrik Jarskog, and Flavio Fröhlich
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2021
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231. The International Federation for Emergency Medicine report on emergency department crowding and access block: a brief summary
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A. P. Javidan, K. Hansen, I. Higginson, P. Jones, E. Lang, and on behalf of the IFEM Task Force on Emergency Department Crowding and Access Block
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Crowding ,Access block ,Care systems ,Emergency care systems ,Emergency department management ,Emergency department operations ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Objective To develop comprehensive guidance that captures international impacts, causes, and solutions related to emergency department crowding and access block Methods Emergency physicians representing 15 countries from all IFEM regions composed the Task Force. Monthly meetings were held via video-conferencing software to achieve consensus for report content. The report was submitted and approved by the IFEM Board on June 1, 2020. Results A total of 14 topic dossiers, each relating to an aspect of ED crowding, were researched and completed collaboratively by members of the Task Force. Conclusions The IFEM report is a comprehensive document intended to be used in whole or by section to inform and address aspects of ED crowding and access block. Overall, ED crowding is a multifactorial issue requiring systems-wide solutions applied at local, regional, and national levels. Access block is the predominant contributor of ED crowding in most parts of the world.
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- 2021
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232. Educational Development Websites: What Do They Tell Us about How Canadian Centres Support the Scholarship of Teaching and Learning?
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Woodhouse, Ros A. and Force, Kristin A.
- Abstract
The study investigates how university educational development centres in Canada currently support faculty in developing the skills and knowledge to engage in the scholarship of teaching and learning. Content analysis of centre websites was used to identify strategies used to support SoTL. The main strategies identified were providing information and grants. Recommendations include increasing the visibility of SoTL on centre websites and integrating it with other centre activities. The data question the viability of a national strategy to improve teaching through SoTL.
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- 2010
233. RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence
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Lin, Chao-Chieh, Mabe, Nathaniel W., Lin, Yi-Tzu, Yang, Wen-Hsuan, Tang, Xiaohu, Hong, Lisa, Sun, Tianai, Force, Jeremy, Marks, Jeffrey R., Yao, Tso-Pang, Alvarez, James V., and Chi, Jen-Tsan
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- 2020
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234. Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients
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Fayanju, Oluwadamilola M., Ren, Yi, Greenup, Rachel A., Plichta, Jennifer K., Rosenberger, Laura H., Force, Jeremy, Suneja, Gita, Devi, Gayathri R., King, Tari A., Nakhlis, Faina, Hyslop, Terry, and Hwang, E. Shelley
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- 2020
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235. Consensus statement on continuous EEG in critically ill adults and children, part II: personnel, technical specifications, and clinical practice.
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Herman, Susan T, Abend, Nicholas S, Bleck, Thomas P, Chapman, Kevin E, Drislane, Frank W, Emerson, Ronald G, Gerard, Elizabeth E, Hahn, Cecil D, Husain, Aatif M, Kaplan, Peter W, LaRoche, Suzette M, Nuwer, Marc R, Quigg, Mark, Riviello, James J, Schmitt, Sarah E, Simmons, Liberty A, Tsuchida, Tammy N, Hirsch, Lawrence J, and Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society
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Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society ,Humans ,Brain Diseases ,Critical Illness ,Electroencephalography ,Monitoring ,Physiologic ,Critical Care ,Adult ,Child ,Female ,Male ,EEG ,EEG monitoring ,Quantitative EEG ,Seizure ,Nonconvulsive seizure ,Status epilepticus ,Nonconvulsive status ,epilepticus ,Intensive care unit ,Critical care ,Adults ,Children ,Monitoring ,Physiologic ,Neurology & Neurosurgery ,Clinical Sciences ,Neurosciences ,Cognitive Sciences - Abstract
IntroductionCritical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status in intensive care units. There is significant variability in patient populations undergoing CCEEG and in technical specifications for CCEEG performance.MethodsThe Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society developed expert consensus recommendations on the use of CCEEG in critically ill adults and children.RecommendationsThe consensus panel describes the qualifications and responsibilities of CCEEG personnel including neurodiagnostic technologists and interpreting physicians. The panel outlines required equipment for CCEEG, including electrodes, EEG machine and amplifier specifications, equipment for polygraphic data acquisition, EEG and video review machines, central monitoring equipment, and network, remote access, and data storage equipment. The consensus panel also describes how CCEEG should be acquired, reviewed and interpreted. The panel suggests methods for patient selection and triage; initiation of CCEEG; daily maintenance of CCEEG; electrode removal and infection control; quantitative EEG techniques; EEG and behavioral monitoring by non-physician personnel; review, interpretation, and reports; and data storage protocols.ConclusionRecommended qualifications for CCEEG personnel and CCEEG technical specifications will facilitate standardization of this emerging technology.
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- 2015
236. Consensus statement on continuous EEG in critically ill adults and children, part I: indications.
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Herman, Susan T, Abend, Nicholas S, Bleck, Thomas P, Chapman, Kevin E, Drislane, Frank W, Emerson, Ronald G, Gerard, Elizabeth E, Hahn, Cecil D, Husain, Aatif M, Kaplan, Peter W, LaRoche, Suzette M, Nuwer, Marc R, Quigg, Mark, Riviello, James J, Schmitt, Sarah E, Simmons, Liberty A, Tsuchida, Tammy N, Hirsch, Lawrence J, and Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society
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Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society ,Humans ,Brain Diseases ,Critical Illness ,Electroencephalography ,Monitoring ,Physiologic ,Critical Care ,Adult ,Child ,Female ,Male ,EEG ,EEG monitoring ,Quantitative EEG ,Seizure ,Nonconvulsive seizure ,Status epilepticus ,Nonconvulsive status ,epilepticus ,Intensive care unit ,Critical care ,Adults ,Children ,Monitoring ,Physiologic ,Neurology & Neurosurgery ,Clinical Sciences ,Neurosciences ,Cognitive Sciences - Abstract
IntroductionCritical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status in intensive care units. There is significant variability in patient populations undergoing CCEEG and in technical specifications for CCEEG performance.MethodsThe Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society developed expert consensus recommendations on the use of CCEEG in critically ill adults and children.RecommendationsThe consensus panel recommends CCEEG for diagnosis of nonconvulsive seizures, nonconvulsive status epilepticus, and other paroxysmal events, and for assessment of the efficacy of therapy for seizures and status epilepticus. The consensus panel suggests CCEEG for identification of ischemia in patients at high risk for cerebral ischemia; for assessment of level of consciousness in patients receiving intravenous sedation or pharmacologically induced coma; and for prognostication in patients after cardiac arrest. For each indication, the consensus panel describes the patient populations for which CCEEG is indicated, evidence supporting use of CCEEG, utility of video and quantitative EEG trends, suggested timing and duration of CCEEG, and suggested frequency of review and interpretation.ConclusionCCEEG has an important role in detection of secondary injuries such as seizures and ischemia in critically ill adults and children with altered mental status.
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- 2015
237. Structure of unbound neutron-rich $^{9}$He studied using single-neutron transfer
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Kalanee, T. Al, Gibelin, J., Roussel-Chomaz, P., Keeley, N., Beaumel, D., Blumenfeld, Y., Fernandez-DomÄ{\pm}nguez, B., Force, C., Gaudefroy, L., Gillibert, A., Guillot, J., Iwasaki, H., Krupko, S., Lapoux, V., Mittig, W., Mougeot, X., Nalpas, L., Pollacco, E., Rusek, K., Roger, T., Savajols, H., De Séréville, N., Sidorchuk, S., Suzuki, D., Strojek, I., and Orr, N. A.
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Nuclear Experiment - Abstract
The 8He(d,p) reaction was studied in inverse kinematics at 15.4A MeV using the MUST2 Si-CsI array in order to shed light on the level structure of 9He. The well known 16O(d,p)17O reaction, performed here in reverse kinematics, was used as a test to validate the experimental methods. The 9He missing mass spectrum was deduced from the kinetic energies and emission angles of the recoiling protons. Several structures were observed above the neutron-emission threshold and the angular distributions were used to deduce the multipolarity of the transitions. This work confirms that the ground state of 9He is located very close to the neutron threshold of 8He and supports the occurrence of parity inversion in 9He., Comment: Exp\'erience GANIL/SPIRAL1/MUST2
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- 2013
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238. Creating a Chain of Teaching and Learning Support: Documenting the Effects of the Teaching Development Graduate Assistant Program
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Force, Kristin A.
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This essay will demonstrate that the teaching development graduate assistant (TDGA) program at the Centre for the Support of Teaching, York University, creates a chain of teaching support between the TDGA coordinator, TDGAs, teaching assistants, faculty, and undergraduate students within a heavily populated university. The importance of teaching and learning workshops for graduate students with minimal university teaching experience will be demonstrated. The methodology for this project includes documenting personal experiences as the TDGA coordinator and informal interviews with TDGAs, discussing their workshops and other activities.
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- 2009
239. ASPHER Statement: Déjà vu? Planning for the Covid-19 Third Wave and Planning for the Winter 2021–22
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Vasco Ricoca Peixoto, John Reid, Henrique Lopes, Vladimir Prikazsky, Ines Siepmann, Jose M. Martin-Moreno, John Middleton, and on behalf of ASPHER COVID task force
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Public Health ,COVID-19 ,pandemic ,third wave ,winter planning ,Public aspects of medicine ,RA1-1270 - Published
- 2021
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240. Emergency medical services education research priorities during COVID‐19: A modified Delphi study
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Rebecca E. Cash, William J. Leggio, Jonathan R. Powell, Kim D. McKenna, Paul Rosenberger, Elliot Carhart, Adrienne Kramer, Juan A. March, Ashish R. Panchal, and for the Pandemic Educational Effects Task Force
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COVID‐19 ,education and training ,emergency medical services ,emergency medical technician ,paramedic ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Objective Our objective was to identify research priorities to understand the impact of COVID‐19 on initial emergency medical services (EMS) education. Methods We used a modified Delphi method with an expert panel (n = 15) of EMS stakeholders to develop consensus on the research priorities that are most important and feasible to understand the impact of the COVID‐19 pandemic on initial EMS education. Data were collected from August 2020 to February 2021 over 5 rounds (3 electronic surveys and 2 live virtual meetings). In Round 1, participants submitted research priorities over 9 specific areas. Responses were thematically analyzed to develop a list of research priorities reviewed in Round 2. In Round 3, participants rated the priorities by importance and feasibility, with a weighted score (2/3*importance+1/3*feasibility) used for preliminary prioritization. In Round 4, participants ranked the priorities. In Round 5, participants provided their agreement or disagreement with the group's consensus of the top 8 research priorities. Results During Rounds 1 and 2, 135 ideas were submitted by the panel, leading to a preliminary list of 27 research priorities after thematic analysis. The top 4 research priorities identified by the expert panel were prehospital internship access, impact of lack of field and clinical experience, student health and safety, and EMS education program availability and accessibility. Consensus was reached with 10/11 (91%) participants in Round 5 agreeing. Conclusions The identified research priorities are an important first step to begin evaluating the EMS educational infrastructure, processes, and outcomes that were affected or threatened through the pandemic.
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- 2021
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241. Genome-wide discovery of drug-dependent human liver regulatory elements.
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Smith, Robin P, Eckalbar, Walter L, Morrissey, Kari M, Luizon, Marcelo R, Hoffmann, Thomas J, Sun, Xuefeng, Jones, Stacy L, Force Aldred, Shelley, Ramamoorthy, Anuradha, Desta, Zeruesenay, Liu, Yunlong, Skaar, Todd C, Trinklein, Nathan D, Giacomini, Kathleen M, and Ahituv, Nadav
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Liver ,Cells ,Cultured ,Hepatocytes ,Humans ,Rifampin ,Histones ,Receptors ,Steroid ,Reproducibility of Results ,Gene Expression Regulation ,Regulatory Sequences ,Nucleic Acid ,Polymorphism ,Single Nucleotide ,Genome ,Human ,p300-CBP Transcription Factors ,Cytochrome P-450 CYP3A ,Promoter Regions ,Genetic ,Hep G2 Cells ,Pregnane X Receptor ,Cells ,Cultured ,Receptors ,Steroid ,Regulatory Sequences ,Nucleic Acid ,Polymorphism ,Single Nucleotide ,Genome ,Human ,Promoter Regions ,Genetic ,Developmental Biology ,Genetics - Abstract
Inter-individual variation in gene regulatory elements is hypothesized to play a causative role in adverse drug reactions and reduced drug activity. However, relatively little is known about the location and function of drug-dependent elements. To uncover drug-associated elements in a genome-wide manner, we performed RNA-seq and ChIP-seq using antibodies against the pregnane X receptor (PXR) and three active regulatory marks (p300, H3K4me1, H3K27ac) on primary human hepatocytes treated with rifampin or vehicle control. Rifampin and PXR were chosen since they are part of the CYP3A4 pathway, which is known to account for the metabolism of more than 50% of all prescribed drugs. We selected 227 proximal promoters for genes with rifampin-dependent expression or nearby PXR/p300 occupancy sites and assayed their ability to induce luciferase in rifampin-treated HepG2 cells, finding only 10 (4.4%) that exhibited drug-dependent activity. As this result suggested a role for distal enhancer modules, we searched more broadly to identify 1,297 genomic regions bearing a conditional PXR occupancy as well as all three active regulatory marks. These regions are enriched near genes that function in the metabolism of xenobiotics, specifically members of the cytochrome P450 family. We performed enhancer assays in rifampin-treated HepG2 cells for 42 of these sequences as well as 7 sequences that overlap linkage-disequilibrium blocks defined by lead SNPs from pharmacogenomic GWAS studies, revealing 15/42 and 4/7 to be functional enhancers, respectively. A common African haplotype in one of these enhancers in the GSTA locus was found to exhibit potential rifampin hypersensitivity. Combined, our results further suggest that enhancers are the predominant targets of rifampin-induced PXR activation, provide a genome-wide catalog of PXR targets and serve as a model for the identification of drug-responsive regulatory elements.
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- 2014
242. Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation
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Kuk Hui Son, Woong-Han Kim, Jae Gun Kwak, Chang-Hyu Choi, Seok In Lee, Ui Won Ko, Hyoung Soo Kim, Haeyoung Lee, Euy Suk Chung, Jae-Bum Kim, Woo Sung Jang, Jae Seung Jung, Jieon Kim, Young Kyung Yoon, Seunghwan Song, Minji Sung, Myung Hun Jang, Young Sam Kim, In-Seok Jeong, Do Wan Kim, Tae Yun Kim, Soon Jin Kim, Su Wan Kim, Joonhwa Hong, Hyungmi An, and on behalf of The Korean Society for Thoracic and Cardiovascular Surgery COVID-19 ECMO Task Force Team
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COVID-19 ,diabetes ,hyperglycemia ,hypoglycemia ,extracorporeal membrane ,Medicine - Abstract
Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged ≥19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) < 18.5 kg/m2. Glucose at admission >200 mg/dL and glucose levels before ventilator >200 mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO >200 mg/dL and minimal glucose levels during hospitalization 200 mg/dL before ECMO and minimal glucose 200 mg/dL before ECMO and minimal glucose level
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- 2022
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243. Response to comments on: All India Ophthalmological Society (AIOS) task force guidelines to prevent intraocular infections
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Lalit Verma, Aniruddha Agarwal, Sabyasachi Sengupta, R D Ravindran, Santosh G Honavar, and For the Members of the AIOS Task Force
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Ophthalmology ,RE1-994 - Published
- 2022
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244. Technology Development for the Caltech Submillimeter Observatory Balanced Receivers
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Kooi, J. W., Chamberlin, R. A., Monje, R., Force, B., Miller, D., and Phillips, T. G.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Caltech Submillimeter Observatory (CSO) is located on top of Mauna Kea, Hawaii, at an altitude of 4.2 km. The existing suite of facility heterodyne receivers covering the submillimeter band is rapidly aging and in need of replacement. To facilitate deep integrations and automated spectral line surveys, a family of remote programmable, synthesized, dual-frequency balanced receivers covering the astronomical important 180 - 720 GHz atmospheric windows is in an advanced stage of development. Installation of the first set of receivers is expected in the spring of 2012. Dual-frequency observation will be an important mode of operation offered by the new facility instrumentation. Two band observations are accomplished by separating the H and V polarizations of the incoming signal and routing them via folded optics to the appropriate polarization sensitive balanced mixer. Scientifically this observation mode facilitates pointing for the higher receiver band under mediocre weather conditions and a doubling of scientific throughput (2 x 4 GHz) under good weather conditions., Comment: 12 pages, 17 figures; IEEE Terahertz Science & Technology, January 2012, Volume 2, Issue 1
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- 2012
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245. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Brauer, Michael, Roth, Gregory A, Aravkin, Aleksandr Y, Zheng, Peng, Abate, Kalkidan Hassen, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abiodun, Olumide, Abiso, Temesgen Lera, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abukhadijah, Hana Jihad Jihad, Aburuz, Salahdein, Abu-Zaid, Ahmed, Adane, Mesafint Molla, Addo, Isaac Yeboah, Addolorato, Giovanni, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afolabi, Aanuoluwapo Adeyimika, Afolabi, Rotimi Felix, Afshin, Ashkan, Afyouni, Shadi, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agbozo, Faith, Aghamiri, Shahin, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Noah, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmed, Ali, Ahmed, Anisuddin, Ahmed, Ayman, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Safoora, Ahmed, Syed Anees, Ajami, Marjan, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akbarialiabad, Hossein, Akhlaghi, Shiva, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akkala, Sreelatha, Akombi-Inyang, Blessing, Al Awaidy, Salah, Al Hasan, Syed Mahfuz, Alahdab, Fares, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Nazmul, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albakri, Almaza, AlBataineh, Mohammad T, Aldhaleei, Wafa A, Aldridge, Robert W, Alemayohu, Mulubirhan Assefa, Alemu, Yihun Mulugeta, Al-Fatly, Bassam, Al-Gheethi, Adel Ali Saeed, Al-Habbal, Khairat, Alhabib, Khalid F, Alhassan, Robert Kaba, Ali, Abid, Ali, Amjad, Ali, Beriwan Abdulqadir, Ali, Iman, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Waad, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Alla, François, Al-Marwani, Sabah, Al-Mekhlafi, Hesham M, Almustanyir, Sami, Alomari, Mahmoud A, Alonso, Jordi, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Raddadi, Rajaa M, Alrawashdeh, Ahmad, Al-Rifai, Rami Hani, Alrousan, Sahel Majed, Al-Sabah, Salman Khalifah, Alshahrani, Najim Z, Altaany, Zaid, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Alwafi, Hassan, Al-Wardat, Mohammad Sami, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Al-Zyoud, Walid, Amaechi, Uchenna Anderson, Aman Mohammadi, Masous, Amani, Reza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Ammirati, Enrico, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Anenberg, Susan C, Angappan, Dhanalakshmi, Angus, Colin, Anil, Abhishek, Anil, Sneha, Anjum, Afifa, Anoushiravani, Amir, Antonazzo, Ippazio Cosimo, Antony, Catherine M, Antriyandarti, Ernoiz, Anuoluwa, Boluwatife Stephen, Anvari, Davood, Anvari, Saeid, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyabolo, Ekenedilichukwu Emmanuel, Anyasodor, Anayochukwu Edward, Apostol, Geminn Louis Carace, Arabloo, Jalal, Arabzadeh Bahri, Razman, Arafat, Mosab, Areda, Demelash, Aregawi, Brhane Berhe, Aremu, Abdulfatai, Armocida, Benedetta, Arndt, Michael Benjamin, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Artanti, Kurnia Dwi, Aruleba, Idowu Thomas, Arumugam, Ashokan, Asbeutah, Akram M, Asgary, Saeed, Asgedom, Akeza Awealom, Ashbaugh, Charlie, Ashemo, Mubarek Yesse, Ashraf, Tahira, Askarinejad, Amir, Assmus, Michael, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atorkey, Prince, Atreya, Alok, Aujayeb, Avinash, Ausloos, Marcel, Avila-Burgos, Leticia, Awoke, Andargie Abate, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayestas Portugal, Carlos, Ayuso-Mateos, Jose L, Azadnajafabad, Sina, Azevedo, Rui M S, Azhar, Gulrez Shah, Azizi, Hosein, Azzam, Ahmed Y, Backhaus, Insa Linnea, Badar, Muhammad, Badiye, Ashish D, Bagga, Arvind, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bahrami Taghanaki, Pegah, Bai, Ruhai, Baig, Atif Amin, Baker, Jennifer L, Bakkannavar, Shankar M, Balasubramanian, Madhan, Baltatu, Ovidiu Constantin, Bam, Kiran, Bandyopadhyay, Soham, Banik, Biswajit, Banik, Palash Chandra, Banke-Thomas, Aduragbemi, Bansal, Hansi, Barchitta, Martina, Bardhan, Mainak, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barrero, Lope H, Barrow, Amadou, Barteit, Sandra, Basharat, Zarrin, Basiru, Afisu, Basso, João Diogo, Bastan, Mohammad-Mahdi, Basu, Sanjay, Batchu, Sai, Batra, Kavita, Batra, Ravi, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Behnoush, Amir Hossein, Beiranvand, Maryam, Béjot, Yannick, Bekele, Alehegn, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Bell, Michelle L, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bendak, Salaheddine, Bennett, Derrick A, Bennitt, Fiona B, Bensenor, Isabela M, Benzian, Habib, Beran, Azizullah, Berezvai, Zombor, Bernabe, Eduardo, Bernstein, Robert S, Bettencourt, Paulo J G, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhuiyan, Mohiuddin Ahmed, Bhutta, Zulfiqar A, Bikbov, Boris, Bishai, Jessica Devin, Bisignano, Catherine, Biswas, Atanu, Biswas, Bijit, Biswas, Raaj Kishore, Bjørge, Tone, Boachie, Micheal Kofi, Boakye, Hosea, Bockarie, Moses John, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bogale, Eyob Ketema, Bolla, Srinivasa Rao, Boloor, Archith, Bonakdar Hashemi, Milad, Boppana, Sri Harsha, Bora Basara, Berrak, Borhany, Hamed, Botero Carvajal, Alejandro, Bouaoud, Souad, Boufous, Soufiane, Bourne, Rupert, Boxe, Christopher, Braithwaite, Dejana, Brant, Luisa C, Brar, Amanpreet, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briko, Andrey Nikolaevich, Britton, Gabrielle, Brown, Colin Stewart, Browne, Annie J, Brunoni, Andre R, Bryazka, Dana, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burkart, Katrin, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cagney, Jack, Cahuana-Hurtado, Lucero, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cao, Fan, Cao, Yubin, Capodici, Angelo, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Caye, Arthur, Cederroth, Christopher R, Cegolon, Luca, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Chadwick, Joshua, Chakraborty, Chiranjib, Chakraborty, Promit Ananyo, Chakraborty, Sandip, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandan, Joht Singh, Chandika, Rama Mohan, Chaturvedi, Pankaj, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Meng Xuan, Chen, Mingling, Chen, Simiao, Cheng, Ching-Yu, Cheng, Esther T W, Cherbuin, Nicolas, Chi, Gerald, Chichagi, Fatemeh, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Chowdhury, Rajiv, Christopher, Devasahayam J, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Sheng-Chia, Chutiyami, Muhammad, Cioffi, Iolanda, Cogen, Rebecca M, Cohen, Aaron J, Columbus, Alyssa, Conde, Joao, Corlateanu, Alexandru, Cortese, Samuele, Cortesi, Paolo Angelo, Costa, Vera Marisa, Costanzo, Simona, Criqui, Michael H, Cruz, Jessica A, Cruz-Martins, Natália, Culbreth, Garland T, da Silva, Alanna Gomes, Dadras, Omid, Dai, Xiaochen, Dai, Zhaoli, Daikwo, Patience Unekwuojo, Dalli, Lachlan L, Damiani, Giovanni, D'Amico, Emanuele, D'Anna, Lucio, Darwesh, Aso Mohammad, Das, Jai K, Das, Subasish, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davitoiu, Dragos Virgil, De la Hoz, Fernando Pio, de la Torre-Luque, Alejandro, De Leo, Diego, Debopadhaya, Shayom, Degenhardt, Louisa, Del Bo', Cristian, Delgado-Enciso, Ivan, Delgado-Saborit, Juana Maria, Demoze, Chalachew Kassaw, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Dervišević, Emina, Desai, Hardik Dineshbhai, Desai, Rupak, Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman, Dhali, Arkadeep, Dhama, Kuldeep, Dhane, Amol S, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dhingra, Sameer, Dhulipala, Vishal R, Dhungana, Raja Ram, Dias da Silva, Diana, Diaz, Daniel, Diaz, Luis Antonio, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Dinu, Monica, Djalalinia, Shirin, Do, Thanh Chi, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dodangeh, Masoud, Dohare, Sushil, Dokova, Klara Georgieva, Dong, Wanyue, Dongarwar, Deepa, D'Oria, Mario, Dorostkar, Fariba, Dorsey, E Ray, Doshi, Rajkumar, Doshmangir, Leila, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Ashel Chelsea, Dsouza, Haneil Larson, Dumith, Samuel C, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Dushpanova, Anar, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Ferry, Eftekharimehrabad, Aziz, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Sayed Zaki, Maysaa, El-Dahiyat, Faris, Elemam, Noha Mousaad, Elgar, Frank J, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, Elmehrath, Ahmed O, Elmeligy, Omar Abdelsadek Abdou, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Esfandiari, Negin, Eshrati, Babak, Eslami, Majid, Esmaeili, Sayed Vahid, Estep, Kara, Etaee, Farshid, Fabin, Natalia, Fagbamigbe, Adeniyi Francis, Fagbule, Omotayo Francis, Fahimi, Saman, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faris, Pawan Sirwan, Faro, Andre, Fasina, Folorunso Oludayo, Fatehizadeh, Ali, Fauk, Nelsensius Klau, Fazylov, Timur, Feigin, Valery L, Feng, Xiaoqi, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrara, Pietro, Ferrari, Alize J, Ferreira, Nuno, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, Fitriana, Ida, Flavel, Joanne, Flohr, Carsten, Flood, David, Flor, Luisa S, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Force, Lisa M, Fortuna, Daniela, Foschi, Matteo, Franklin, Richard Charles, Freitas, Alberto, Friedman, Sara D, Fux, Blima, G, Sridevi, Gaal, Peter Andras, Gaihre, Santosh, Gajdács, Márió, Galali, Yaseen, Gallus, Silvano, Gandhi, Aravind P, Ganesan, Balasankar, Ganiyani, Mohammad Arfat, Garcia, Vanessa, Gardner, William M, Garg, Ravindra K, Gautam, Rupesh K, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremariam, Tesfay B B, Gebremeskel, Teferi Gebru, Gerema, Urge, Getacher, Lemma, Getahun, Genanew K a, Getie, Molla, Ghadirian, Fataneh, Ghafarian, Sadegh, Ghaffari Jolfayi, Amir, Ghailan, Khalid Yaser, Ghajar, Alireza, Ghasemi, MohammadReza, Ghasempour Dabaghi, Ghazal, Ghasemzadeh, Afsaneh, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Gholami, Ali, Gholamrezanezhad, Ali, Gholizadeh, Nasim, Ghorbani, Mahsa, Gil, Artyom Urievich, Gil, Gabriela Fernanda, Gilbertson, Nora M, Gill, Paramjit Singh, Gill, Tiffany K, Gindaba, Ebisa Zerihun, Girmay, Alem, Glasbey, James C, Gnedovskaya, Elena V, Göbölös, Laszlo, Godinho, Myron Anthony, Goel, Amit, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Gomes, Nelson G M, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C, Gouravani, Mahdi, Goyal, Anmol, Graham, Simon Matthew, Grivna, Michal, Grosso, Giuseppe, Guan, Shi-Yang, Guarducci, Giovanni, Gubari, Mohammed Ibrahim Mohialdeen, Guha, Avirup, Guicciardi, Stefano, Gulati, Snigdha, Gulisashvili, David, Gunawardane, Damitha Asanga, Guo, Cui, Gupta, Anish Kumar, Gupta, Bhawna, Gupta, Mohak, Gupta, Rahul, Gupta, Rajat Das, Gupta, Rajeev, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vijai Kumar, Gupta, Vivek Kumar, Habibzadeh, Farrokh, Habibzadeh, Parham, Hadaro, Tesfahun Simon, Hadian, Zahra, Haep, Nils, Haghi-Aminjan, Hamed, Haghmorad, Dariush, Hagins, Hailey, Haile, Demewoz, Hailu, Alemayehu, Hajj Ali, Adel, 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- Abstract
Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021.
- Published
- 2024
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246. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Theo, and Murray, Christopher J L
- Abstract
Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic.
- Published
- 2024
- Full Text
- View/download PDF
247. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
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- Abstract
Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.
- Published
- 2024
- Full Text
- View/download PDF
248. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
- Author
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Vollset, Stein Emil, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abd Al Magied, Abdallah H A, Abd ElHafeez, Samar, Abdelkader, Atef, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Absalan, Abdorrahim, Abualruz, Hasan, Abubakar, Bilyaminu, Abukhadijah, Hana Jihad Jihad, Addolorato, Giovanni, Adekanmbi, Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adhikary, Ripon Kumar, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afrashteh, Fatemeh, Afzal, Muhammad Sohail, Afzal, Saira, Agbozo, Faith, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, 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- Abstract
Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050.
- Published
- 2024
- Full Text
- View/download PDF
249. What PADMA Wants.
- Author
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LA FORCE, THESSALY
- Published
- 2024
250. Study of $^{124}$Sn+$^{136}$Xe fusion-evaporation: analysis of a rare-event experiment
- Author
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Avez, Benoît, Drouart, Antoine, Stodel, Ch., Simenel, Cédric, Alcantara, J., Adamczyk, M., Banka, P., Bonnet, E., Clément, E., Dayras, R., Force, C., Golabek, C., Gonciarz, A., Grevy, S., Hauschild, K., Jacquet, D., Korichi, A., Kozik, T., Lazko, P., Morjean, M., Popeko, A., Roger, T., Saint-Laurent, M. -G., Sosin, Z., Sulignano, B., Theisen, C., Wieloch, A., Yeremin, A., Yilmaz, B., and Zielinska, M.
- Subjects
Nuclear Experiment - Abstract
Fusion-evaporation in the $^{124}$Sn+$^{136}$Xe system is studied using a high intensity xenon beam provided by the Ganil accelerator and the LISE3 wien filter for the selection of the products. Due to the mass symmetry of the entrance system, the rejection of the beam by the spectrometer was of the order of $5times10^8$. We have thus performed a detailed statistical analysis to estimate random events and to infer the fusion-evaporation cross sections. No signicant decay events were detected and upper limit cross sections of 172 pb, 87 pb and 235 pb were deduced for the synthesis of $^{257}$Rf, $^{258}$Rf and $^{259}$Rf, respectively., Comment: 7 pages, 4 figures
- Published
- 2011
Catalog
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