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1,677 results on '"Fisher, David E"'

208. [beta]-Catenin--induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

Author

Widlund, Hans R., Horstmann, Martin A., Price, E. Roydon, Cui, Junqing, Lessnick, Stephen L., Wu, Min, He, Xi, and Fisher, David E.

Subjects
Melanoma -- Growth, Cell differentiation -- Physiological aspects, Melanocytes -- Growth, Genetic transcription -- Regulation, Biological sciences
Abstract

The transcription factor Microphthalmia-associated transcription factor (MITF) is a lineage-determination factor, which modulates melanocyte differentiation and pigmentation. MITF was recently shown to reside down-stream of the canonical Wnt pathway during melanocyte differentiation from pluripotent neural crest cells in zebrafish as well as in mammalian melanocyte lineage cells. Although expression of many melanocytic/pigmentation markers is lost in human melanoma, MITF expression remains intact, even in unpigmented tumors, suggesting a role for MITF beyond its role in differentiation. A significant fraction of primary human melanomas exhibit deregulation (via aberrant nuclear accumulation) of [beta]-catenin, leading us to examine its role in melanoma growth and survival. Here, we show that [beta]-catenin is a potent mediator of growth for melanoma cells in a manner dependent on its downstream target MITE Moreover, suppression of melanoma clonogenic growth by disruption of [beta]-catenin-T-cell transcription factor/ LEF is rescued by constitutive MITF. This rescue occurs largely through a prosurvival mechanism. Thus, [beta]-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm.

Published
2002

209. Preface

Author

Look, A. Thomas, primary and Fisher, David E., additional

Published
2009
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210. Contributors

Author

Albritton, Karen, primary, Amatruda, James F., additional, Anderson, Megan E., additional, Argani, Pedram, additional, Armstrong, Scott A., additional, Baker, Sharyn D., additional, Barfield, Raymond C., additional, Barr, Frederic G., additional, Berde, Charles B., additional, Berman, Jason N., additional, Bernstein, Mark L., additional, Bhatia, Smita, additional, Billett, Amy Louise, additional, Blackman, Samuel, additional, Branowicki, Patricia A., additional, Casey, Robert L., additional, Chi, Susan N., additional, Clark, Jennifer J., additional, Conley, Susanne B., additional, Davis, Ian J., additional, Degar, Barbara A., additional, DeSantes, Kenneth B., additional, Diller, Lisa, additional, Dome, Jeffrey S., additional, DuBois, Steven G., additional, Duncan, Janet, additional, Dunn, Ian F., additional, Evan, Elana E., additional, Evans, William E., additional, Felix, Carolyn A., additional, Ferrando, Adolfo A., additional, Fisher, David E., additional, Fleming, Mark D., additional, Fletcher, Jonathan A., additional, Folkman, Judah, additional, Frazier, A. Lindsay, additional, Gebhardt, Mark C., additional, George, Rani E., additional, Goldberg, John M., additional, Gorlick, Richard, additional, Grabowski, Eric F., additional, Grier, Holcombe E., additional, Haas-Kogan, Daphne, additional, Hahn, William C., additional, Herrington, Betsy, additional, Houlahan, Kathleen E., additional, Italiano, Joseph E., additional, Janeway, Katherine A., additional, Kenney, Lisa B., additional, Kieran, Mark W., additional, Kim, Heung Bae, additional, Kiss, Szilárd, additional, Kodish, Eric, additional, Koh, Andrew Y., additional, Lechpammer, Mirna, additional, Leiderman, Yannek I., additional, Lessnick, Stephen L., additional, Look, A. Thomas, additional, Mack, Jennifer W., additional, Marcus, Karen J., additional, Mukai, Shizuo, additional, Mullen, Elizabeth, additional, O'Sullivan, Maureen J., additional, Pappo, Alberto, additional, Perez-Atayde, Antonio R., additional, Pizzo, Philip A., additional, Prabhu, Sanjay P., additional, Recklitis, Christopher J., additional, Reiter, Alfred, additional, Roberts, Charles W.M., additional, Robison, Leslie L., additional, Rollins, Barrett J., additional, Samuel, David, additional, Schlis, Krysta D., additional, Segal, Rosalind A., additional, Sellers, William R., additional, Shamberger, Robert C., additional, Shusterman, Suzanne, additional, Silverman, Lewis B., additional, Sondel, Paul M., additional, Sparreboom, Alex, additional, Stegmaier, Kimberly, additional, Tomlinson, Gail E., additional, Turner, Christopher, additional, Ullrich, Christina K., additional, Voss, Stephan D., additional, Vrooman, Lynda M., additional, Weldon, Christopher B., additional, Whangbo, Jennifer, additional, Wolfe, Joanne, additional, Womer, Richard B., additional, and Zeltzer, Lonnie, additional

Published
2009
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212. Bcl2 regulation by the melanocyte master regulator mitf modulates lineage survival and melanoma cell viability

Author

McGill, Gael G., Horstmann, Martin, Widlund, Hand R., Du, Jinyan, Motyckova, Gabriela, Nishimura, Emi K., Lin, Yi-Ling, Ramaswamy, Sridhar, Avery, Siobhan A., Jackson, Ian J., Korsmeyer, Stanley J., Golub, Todd R., and Fisher, David E.

Subjects
Melanocytes -- Genetic aspects, Melanoma -- Genetic aspects, Genetic transcription -- Regulation, Biological sciences
Abstract

The development of melanocyte is influenced by Kit//SCF signaling and Mitf-dependent transcription through target genes such as Bcl2. Research demonstrates that Mitf and Bcl2 genetically interact during melanocyte development in terms of Mitf regulation of endogenous levels of BCL2 in melanocytes and melanomas and modulation of BCL2 expression..

Published
2002

215. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Author

Weiss-Sadan, Tommy, Ge, Maolin, Hayashi, Makiko, Gohar, Magdy, Yao, Cong-Hui, de Groot, Adriaan, Harry, Stefan, Carlin, Alexander, Fischer, Hannah, Shi, Lei, Wei, Ting-Yu, Adelmann, Charles H., Wolf, Konstantin, Vornbäumen, Tristan, Dürr, Benedikt R., Takahashi, Mariko, Richter, Marianne, Zhang, Junbing, Yang, Tzu-Yi, Vijay, Vindhya, Fisher, David E., Hata, Aaron N., Haigis, Marcia C., Mostoslavsky, Raul, Bardeesy, Nabeel, Papagiannakopoulos, Thales, and Bar-Peled, Liron

Published
2023
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216. Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

Author

Lo, Jennifer A., primary, Kawakubo, Masayoshi, additional, Juneja, Vikram R., additional, Su, Mack Y., additional, Erlich, Tal H., additional, LaFleur, Martin W., additional, Kemeny, Lajos V., additional, Rashid, Mamunur, additional, Malehmir, Mohsen, additional, Rabi, S. Alireza, additional, Raghavan, Rumya, additional, Allouche, Jennifer, additional, Kasumova, Gyulnara, additional, Frederick, Dennie T., additional, Pauken, Kristen E., additional, Weng, Qing Yu, additional, Pereira da Silva, Marcelo, additional, Xu, Yu, additional, van der Sande, Anita A. J., additional, Silkworth, Whitney, additional, Roider, Elisabeth, additional, Browne, Edward P., additional, Lieb, David J., additional, Wang, Belinda, additional, Garraway, Levi A., additional, Wu, Catherine J., additional, Flaherty, Keith T., additional, Brinckerhoff, Constance E., additional, Mullins, David W., additional, Adams, David J., additional, Hacohen, Nir, additional, Hoang, Mai P., additional, Boland, Genevieve M., additional, Freeman, Gordon J., additional, Sharpe, Arlene H., additional, Manstein, Dieter, additional, and Fisher, David E., additional

Published
2021
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218. The State of Melanoma: Emergent Challenges and Opportunities

Author

Atkins, Michael B., primary, Curiel-Lewandrowski, Clara, additional, Fisher, David E., additional, Swetter, Susan M., additional, Tsao, Hensin, additional, Aguirre-Ghiso, Julio A., additional, Soengas, Maria S., additional, Weeraratna, Ashani T., additional, Flaherty, Keith T., additional, Herlyn, Meenhard, additional, Sosman, Jeffrey A., additional, Tawbi, Hussein A., additional, Pavlick, Anna C., additional, Cassidy, Pamela B., additional, Chandra, Sunandana, additional, Chapman, Paul B., additional, Daud, Adil, additional, Eroglu, Zeynep, additional, Ferris, Laura K., additional, Fox, Bernard A., additional, Gershenwald, Jeffrey E., additional, Gibney, Geoffrey T., additional, Grossman, Douglas, additional, Hanks, Brent A., additional, Hanniford, Douglas, additional, Hernando, Eva, additional, Jeter, Joanne M., additional, Johnson, Douglas B., additional, Khleif, Samir N., additional, Kirkwood, John M., additional, Leachman, Sancy A., additional, Mays, Darren, additional, Nelson, Kelly C., additional, Sondak, Vernon K., additional, Sullivan, Ryan J., additional, and Merlino, Glenn, additional

Published
2021
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227. Abstract 62: Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Author

Montero, Joan, primary, Gstalder, Cecile, additional, Kim, Daniel J., additional, Sadowicz, Dorota, additional, Miles, Wayne, additional, Manos, Michael, additional, Cidado, Justin R., additional, Secrist, J. Paul, additional, Tron, Adriana E., additional, Flaherty, Keith, additional, Hodi, F. Stephen, additional, Yoon, Charles H., additional, Letai, Anthony, additional, Fisher, David E., additional, and Haq, Rizwan, additional

Published
2020
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229. Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis

Author

Kato, Shinichiro, primary, Weng, Qing Yu, additional, Insco, Megan L., additional, Chen, Kevin Y., additional, Muralidhar, Sathya, additional, Pozniak, Joanna, additional, Diaz, Joey Mark S., additional, Drier, Yotam, additional, Nguyen, Nhu, additional, Lo, Jennifer A., additional, van Rooijen, Ellen, additional, Kemeny, Lajos V., additional, Zhan, Yao, additional, Feng, Yang, additional, Silkworth, Whitney, additional, Powell, C. Thomas, additional, Liau, Brian B., additional, Xiong, Yan, additional, Jin, Jian, additional, Newton-Bishop, Julia, additional, Zon, Leonard I., additional, Bernstein, Bradley E., additional, and Fisher, David E., additional

Published
2020
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231. Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells

Author

Tay, Rong En, primary, Olawoyin, Olamide, additional, Cejas, Paloma, additional, Xie, Yingtian, additional, Meyer, Clifford A., additional, Ito, Yoshinaga, additional, Weng, Qing Yu, additional, Fisher, David E., additional, Long, Henry W., additional, Brown, Myles, additional, Kim, Hye-Jung, additional, and Wucherpfennig, Kai W., additional

Published
2020
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233. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi

Author

Wu, Min, Hemesath, Timothy J., Takemoto, Clifford M., Horstmann, Martin A., Wells, Audrey G., Price, E. Roydon, Fisher, Daniel Z., and Fisher, David E.

Subjects
Genetic research -- Analysis, Phosphorylation -- Analysis, Melanocytes -- Research, Genetic transcription -- Research, Ubiquitin -- Research, Biological sciences
Abstract

Research has been conducted on microphthalmia (Mi), a transcriptional factor that is essential for melanocyte development. The effect of c-Kit signaling on Mi phosphorylation has been described.

Published
2000

245. Immunotherapy in the Precision Medicine Era: Melanoma and Beyond

Author

Su, Mack Y. and Fisher, David E.

Subjects
Care and treatment, Development and progression, Forecasts and trends, Market trend/market analysis, Precision medicine -- Forecasts and trends, Immunotherapy -- Forecasts and trends, Melanoma -- Development and progression -- Care and treatment
Abstract

Author(s): Mack Y. Su, David E. Fisher * Innovations in cancer immunotherapy over the past decade have reinvigorated the field, which currently stands poised to transform treatment of certain important [...]

Published
2016
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247. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

Author

Zhang, Bing, Ma, Sai, Rachmin, Inbal, He, Megan, Baral, Pankaj, Choi, Sekyu, Gonçalves, William A., Shwartz, Yulia, Fast, Eva M., Su, Yiqun, Zon, Leonard I., Regev, Aviv, Buenrostro, Jason D., Cunha, Thiago M., Chiu, Isaac M., Fisher, David E., and Hsu, Ya-Chieh

Subjects
Male, Sympathetic Nervous System, Stem Cells, Adrenalectomy, Psychological Trauma, Denervation, Article, Mice, Norepinephrine, Adrenal Glands, Animals, Humans, Melanocytes, Autonomic Pathways, Female, Receptors, Adrenergic, beta-2, Stem Cell Niche, Hair Color, Cells, Cultured, Stress, Psychological, Cell Proliferation
Abstract

SUMMARY Empirical and anecdotal evidence have associated stress with accelerated hair greying (formation of unpigmented hairs)1,2, but the scientific evidence linking the two is scant. Here, we report that acute stress leads to hair greying through fast depletion of melanocyte stem cells (MeSCs). Combining adrenalectomy, denervation, chemogenetics3,4, cell ablation, and MeSC-specific adrenergic receptor knockout, we found that stress-induced MeSC loss is independent of immune attack or adrenal stress hormones. Rather, hair greying results from activation of the sympathetic nerves that innervate the MeSC niche. Upon stress, sympathetic nerve activation leads to burst release of the neurotransmitter norepinephrine, which drives quiescent MeSCs into rapid proliferation, followed by differentiation, migration, and permanent depletion from the niche. Transient suppression of MeSC proliferation prevents stress-induced hair greying. Our studies demonstrate that acute stress-induced neuronal activity can drive rapid and permanent loss of somatic stem cells, and illustrate an example in which somatic stem cell maintenance is directly influenced by the overall physiological state of the organism.

Published
2019

250. Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

Author

Bertolotto, Corine, Abbe, Patricia, Hemesath, Timothy J., Bille, Karine, Fisher, David E., Ortonne, Jean-Paul, and Ballotti, Robert

Subjects
Melanocytes -- Genetic aspects, Cellular signal transduction -- Analysis, Melanosis -- Research, Cyclic adenylic acid -- Research, Biological sciences
Abstract

A study was conducted to identify the process by which cAMP controls microphthalmia function and to determine the role of microphthalmia in cAMP-induced melanogenesis and pigment cell differentiation. Results showed that a classical cAMP response element was used to upregulate gene transcription in microphthalmia. The cAMP effect on tyrosine promoter also required the said gene.

Published
1998

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