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234. 3310-3314

Author

Finkel, B. F., Pelletier, A., Uspensky, J. V., Johnston, L. S., and Reynolds, J. B.

Published
1928
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245. Differences in metabolic side-effects of typical and atypical antipsychotic treatment in elderly individuals with long-term schizophrenia.

Author

Finkel B, Goodman C, Melamed Y, Naser M, Andreyev P, Segev Y, and Bleich A

Abstract

Objectives: To examine metabolic side-effects of year-long treatment with clozapine, risperidone, quetiapine, or olanzapine in comparison to treatment with haloperidol or perphenazine, among elderly individuals with long-term schizophrenia. Participants and Methods: In a retrospective chart review, clinical records of 228 psychiatric inpatients with persistent schizophrenia were examined to determine any differences in metabolic side-effects of typical versus atypical antipsychotic treatment. Results: There were no significant differences with respect to body mass index, body weight, blood glucose, and serum triglyceride, cholesterol, B12, and folic acid levels. Conclusions: Elderly psychogeriatric patients may be less susceptible to the metabolic side-effects associated with atypical antipsychotic agents than younger populations. This finding warrants further investigation in prospective randomised controlled trials. [ABSTRACT FROM AUTHOR]

Published
2009

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