Search

Your search keyword '"Ferriero, Donna"' showing total 1,629 results
Start Over Author "Ferriero, Donna"
1,629 results on '"Ferriero, Donna"'

203. A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C

Author

Mikrogeorgiou, Alkisti, Chen, Yiran, Lee, Byong Sop, Bok, Robert, Sheldon, R Ann, Barkovich, A James, Xu, Duan, and Ferriero, Donna M

Subjects
Pyruvate, Paediatrics and Reproductive Medicine, Metabolism, Neurology & Neurosurgery, Hyperpolarized(13)C, Magnetic resonance spectroscopy, Neurosciences, Lactate, Cognitive Sciences, Neonatal brain injury, Developing brain, Hyperpolarized 13C
Abstract

BackgroundHyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism.MethodsMice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13C MRS to investigate the metabolic exchange of pyruvate to lactate in real time during brain development following HI. 13C-1-labeled pyruvate was hyperpolarized and injected into the tail vein through a tail-vein catheter. Chemical-shift imaging was performed to acquire spectral-spatial information of the metabolites in the brain. A voxel placed on each of the injured and contralateral hemispheres was chosen for comparison. The difference in pyruvate delivery and lactate to pyruvate ratio was calculated for each of the voxels at each time point. The normalized lactate level of the injured hemisphere was also calculated for each mouse at each of the scanning time points.ResultsThere was a significant reduction in pyruvate delivery and a higher lactate to pyruvate ratio in the ipsilateral (HI) hemisphere at P10. The differences decreased at P17 and disappeared at P31. The normalized lactate level in the injured hemisphere increased from P10 to P31 in both sham and HI mice without brain injury.ConclusionWe describe a method for detecting and monitoring the evolution of HI injury during brain maturation which could prove to be an excellent biomarker of injury.

Published
2020

204. JCB911910 Supplemental Material - Supplemental material for Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice

Author

Fuxin Lu, Shujuan Fan, Romo, Andrea R, Xu, Duan, Ferriero, Donna M, and Xiangning Jiang

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, JCB911910 Supplemental Material for Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice by Fuxin Lu, Shujuan Fan, Andrea R Romo, Duan Xu, Donna M Ferriero and Xiangning Jiang in Journal of Cerebral Blood Flow & Metabolism

Published
2020
Full Text
View/download PDF

206. Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association

Author

Ferriero, Donna M, Fullerton, Heather J, Bernard, Timothy J, Billinghurst, Lori, Daniels, Stephen R, DeBaun, Michael R, deVeber, Gabrielle, Ichord, Rebecca N, Jordan, Lori C, Massicotte, Patricia, Meldau, Jennifer, Roach, E Steve, Smith, Edward R, and American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing

Subjects
Adolescent, infarction, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Cardiovascular, Pediatrics, Brain Ischemia, Association, Rare Diseases, Clinical Research, Humans, genetics, Child, Preschool, thrombosis, Pediatric, Cardiovascular Medicine And Haematology, Neurology & Neurosurgery, Incidence, American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing, Neurosciences, Infant, perinatal care, American Heart Association, Hematology, Newborn, United States, Brain Disorders, Stroke, AHA Scientific Statements, Good Health and Well Being, cerebrovascular accident
Abstract

Purpose- Much has transpired since the last scientific statement on pediatric stroke was published 10 years ago. Although stroke has long been recognized as an adult health problem causing substantial morbidity and mortality, it is also an important cause of acquired brain injury in young patients, occurring most commonly in the neonate and throughout childhood. This scientific statement represents a synthesis of data and a consensus of the leading experts in childhood cardiovascular disease and stroke. Methods- Members of the writing group were appointed by the American Heart Association Stroke Council's Scientific Statement Oversight Committee and the American Heart Association's Manuscript Oversight Committee and were chosen to reflect the expertise of the subject matter. The writers used systematic literature reviews, references to published clinical and epidemiology studies, morbidity and mortality reports, clinical and public health guidelines, authoritative statements, personal files, and expert opinion to summarize existing evidence and to indicate gaps in current knowledge. This scientific statement is based on expert consensus considerations for clinical practice. Results- Annualized pediatric stroke incidence rates, including both neonatal and later childhood stroke and both ischemic and hemorrhagic stroke, range from 3 to 25 per 100 000 children in developed countries. Newborns have the highest risk ratio: 1 in 4000 live births. Stroke is a clinical syndrome. Delays in diagnosis are common in both perinatal and childhood stroke but for different reasons. To develop new strategies for prevention and treatment, disease processes and risk factors that lead to pediatric stroke are discussed here to aid the clinician in rapid diagnosis and treatment. The many important differences that affect the pathophysiology and treatment of childhood stroke are discussed in each section. Conclusions- Here we provide updates on perinatal and childhood stroke with a focus on the subtypes, including arterial ischemic, venous thrombotic, and hemorrhagic stroke, and updates in regard to areas of childhood stroke that have not received close attention such as sickle cell disease. Each section is highlighted with considerations for clinical practice, attendant controversies, and knowledge gaps. This statement provides the practicing provider with much-needed updated information in this field.

Published
2019
Full Text
View/download PDF

240. Hypothermia and Other Treatment Options for Neonatal Encephalopathy: An Executive Summary of the Eunice Kennedy Shriver NICHD Workshop

Author

Higgins, Rosemary D., Raju, Tonse, Edwards, David A., Azzopardi, Denis V., Bose, Carl L., Clark, Reese H., Ferriero, Donna M., Guillet, Ronnie, Gunn, Alistair J., Hagberg, Henrik, Hirtz, Deborah, Inder, Terrie E., Jacobs, Susan E., Jenkins, Dorothea, Juul, Sandra, Laptook, Abbot R., Lucey, Jerold F., Maze, Mervyn, Palmer, Charles, Papile, LuAnn, Pfister, Robert H., Robertson, Nicola J., Rutherford, Mary, Shankaran, Seetha, Silverstein, Faye S., Soll, Roger F., Thoresen, Marianne, and Walsh, William F.

Published
2011
Full Text
View/download PDF

247. Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures.

Author

Cornet, Marie‐Coralie, Morabito, Valeria, Lederer, Damien, Glass, Hannah C., Ferrao Santos, Susana, Numis, Adam L., Ferriero, Donna M., Sands, Tristan T., and Cilio, Maria Roberta

Subjects
EPILEPSY, SEIZURES (Medicine), INTENSIVE care units, NEONATAL intensive care, NEWBORN infants, DIAGNOSIS
Abstract

Objective: Although most seizures in neonates are due to acute brain injury, some represent the first sign of neonatal onset genetic epilepsies. Delay in recognition and lack of expert assessment of neonates with epilepsy may result in worse developmental outcomes. As in older children and adults, seizure semiology in neonates is an essential determinant in diagnosis. We aimed to establish whether seizure type at presentation in neonates can suggest a genetic etiology. Methods: We retrospectively analyzed the clinical and electroencephalographic (EEG) characteristics of seizures in neonates admitted in two Level IV neonatal intensive care units, diagnosed with genetic epilepsy, for whom a video‐EEG recording at presentation was available for review, and compared them on a 1:2 ratio with neonates with seizures due to stroke or hypoxic–ischemic encephalopathy. Results: Twenty neonates with genetic epilepsy were identified and compared to 40 neonates with acute provoked seizures. Genetic epilepsies were associated with pathogenic variants in KCNQ2 (n = 12), KCNQ3 (n = 2), SCN2A (n = 2), KCNT1 (n = 1), PRRT2 (n = 1), and BRAT1 (n = 2). All neonates with genetic epilepsy had seizures with clinical correlates that were either tonic (18/20) or myoclonic (2/20). In contrast, 17 of 40 (42%) neonates with acute provoked seizures had electrographic only seizures, and the majority of the remainder had clonic seizures. Time to first seizure was longer in neonates with genetic epilepsies (median = 60 h of life) compared to neonates with acute provoked seizures (median = 15 h of life, p <.001). Sodium channel‐blocking antiseizure medications were effective in 13 of 14 (92%) neonates with tonic seizures who were trialed at onset or during the course of the epilepsy. Significance: Seizure semiology is an easily accessible sign of genetic epilepsies in neonates. Early identification of the seizure type can prompt appropriate workup and treatment. Tonic seizures are associated with channelopathies and are often controlled by sodium channel‐blocking antiseizure medications. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results