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757 results on '"Fernández, Facundo M."'

204. Biomarkers of Whale Shark Health: A Metabolomic Approach

Author

Dove, Alistair D. M., primary, Leisen, Johannes, additional, Zhou, Manshui, additional, Byrne, Jonathan J., additional, Lim-Hing, Krista, additional, Webb, Harry D., additional, Gelbaum, Leslie, additional, Viant, Mark R., additional, Kubanek, Julia, additional, and Fernández, Facundo M., additional

Published
2012
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206. Thermodynamic activation and structural analysis of trypsin I from Monterey sardine (Sardinops sagax caerulea)

Author

Arvizu-Flores, Aldo A., primary, Quintero-Reyes, Idania E., additional, Felix-Lopez, Martha, additional, Islas-Osuna, Maria A., additional, Yepiz-Plascencia, Gloria, additional, Pacheco-Aguilar, Ramón, additional, Navare, Arti, additional, Fernández, Facundo M., additional, Velazquez-Contreras, Enrique F., additional, Sotelo-Mundo, Rogerio R., additional, and Castillo-Yañez, Francisco J., additional

Published
2012
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210. Feasibility of Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics: A Pilot Study

Author

Zang, Xiaoling, Monge, María Eugenia, McCarty, Nael A., Stecenko, Arlene A., and Fernández, Facundo M.

Abstract

Progressive lung function decline and, ultimately, respiratory failure are the most common cause of death in patients with cystic fibrosis (CF). This decline is punctuated by acute pulmonary exacerbations (APEs), and in many cases, there is a failure to return to baseline lung function. Ultraperformance liquid chromatography quadrupole-time-of-flight mass spectrometry was used to profile metabolites in exhaled breath condensate (EBC) samples from 17 clinically stable CF patients, 9 CF patients with an APE severe enough to require hospitalization (termed APE), 5 CF patients during recovery from a severe APE (termed post-APE), and 4 CF patients who were clinically stable at the time of collection but in the subsequent 1–3 months developed a severe APE (termed pre-APE). A panel containing two metabolic discriminant features, 4-hydroxycyclohexylcarboxylic acid and pyroglutamic acid, differentiated the APE samples from the stable CF samples with 84.6% accuracy. Pre-APE samples were distinguished from stable CF samples by lactic acid and pyroglutamic acid with 90.5% accuracy and in general matched the APE signature when projected onto the APE vs stable CF model. Post-APE samples were on average more similar to stable CF samples in terms of their metabolomic signature. These results show the feasibility of detecting and predicting an oncoming APE or monitoring APE treatment using EBC metabolites.

Published
2017
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216. Medications for Sexual Health Available from Non-Medical Sources: A Need for Increased Access to Healthcare and Education Among Immigrant Latinos in the Rural Southeastern USA

Author

Rhodes, Scott D., primary, Fernández, Facundo M., additional, Leichliter, Jami S., additional, Vissman, Aaron T., additional, Duck, Stacy, additional, O’Brien, Mary Claire, additional, Miller, Cindy, additional, Wilkin, Aimee M., additional, Harris, Glenn A., additional, Hostetler, Dana M., additional, and Bloom, Fred R., additional

Published
2010
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227. A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR – implications for therapeutic failure and drug resistance

Author

Sengaloundeth, Sivong, primary, Green, Michael D, additional, Fernández, Facundo M, additional, Manolin, Ot, additional, Phommavong, Khamlieng, additional, Insixiengmay, Vongsavanh, additional, Hampton, Christina Y, additional, Nyadong, Leonard, additional, Mildenhall, Dallas C, additional, Hostetler, Dana, additional, Khounsaknalath, Lamphet, additional, Vongsack, Latsamy, additional, Phompida, Samlane, additional, Vanisaveth, Viengxay, additional, Syhakhang, Lamphone, additional, and Newton, Paul N, additional

Published
2009
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228. Combining Two-Dimensional Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopy, Imaging Desorption Electrospray Ionization Mass Spectrometry, and Direct Analysis in Real-Time Mass Spectrometry for the Integral Investigation of Counterfeit Pharmaceuticals

Author

Nyadong, Leonard, primary, Harris, Glenn A., additional, Balayssac, Stéphane, additional, Galhena, Asiri S., additional, Malet-Martino, Myriam, additional, Martino, Robert, additional, Parry, R. Mitchell, additional, Wang, May Dongmei, additional, Fernández, Facundo M., additional, and Gilard, Véronique, additional

Published
2009
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229. Guidelines for Field Surveys of the Quality of Medicines: A Proposal

Author

Newton, Paul N, primary, Lee, Sue J, additional, Goodman, Catherine, additional, Fernández, Facundo M, additional, Yeung, Shunmay, additional, Phanouvong, Souly, additional, Kaur, Harparkash, additional, Amin, Abdinasir A, additional, Whitty, Christopher J. M, additional, Kokwaro, Gilbert O, additional, Lindegårdh, Niklas, additional, Lukulay, Patrick, additional, White, Lisa J, additional, Day, Nicholas P. J, additional, Green, Michael D, additional, and White, Nicholas J, additional

Published
2009
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234. Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: Selecting for Drug-resistant Malaria and Threatening Public Health

Author

Newton, Paul N., primary, Day, Nicholas P. J., additional, Ruangveerayuth, Ronnatrai, additional, Alter-Hall, Krystyn, additional, Tudino, Mabel B., additional, White, Nicholas J., additional, Teerwarakulpana, Thanongsak, additional, Mancuso, Natalia, additional, Prakongpan, Sompol, additional, Hampton, Christina Y., additional, and Fernández, Facundo M., additional

Published
2008
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236. A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia

Author

Newton, Paul N, primary, Fernández, Facundo M, additional, Plançon, Aline, additional, Mildenhall, Dallas C, additional, Green, Michael D, additional, Ziyong, Li, additional, Christophel, Eva Maria, additional, Phanouvong, Souly, additional, Howells, Stephen, additional, McIntosh, Eric, additional, Laurin, Paul, additional, Blum, Nancy, additional, Hampton, Christina Y, additional, Faure, Kevin, additional, Nyadong, Leonard, additional, Soong, C. W. Ray, additional, Santoso, Budiono, additional, Zhiguang, Wang, additional, Newton, John, additional, and Palmer, Kevin, additional

Published
2008
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240. Corrigendum to “Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality” [J. Pharm. Biomed. Anal. 43 (2007) 105–110]

Author

Green, Michael D., primary, Nettey, Henry, additional, Rojas, Ofelia Villalva, additional, Pamanivong, Chansapha, additional, Khounsaknalath, Lamphet, additional, Ortiz, Miguel Grande, additional, Newton, Paul N., additional, Fernández, Facundo M., additional, Vongsack, Latsamy, additional, and Manolin, Ot, additional

Published
2007
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247. Unknown Metabolite Identification Using Machine Learning Collision Cross-Section Prediction and Tandem Mass Spectrometry

Author

Asef, Carter K., Rainey, Markace A., Garcia, Brianna M., Gouveia, Goncalo J., Shaver, Amanda O., Leach, Franklin E., Morse, Alison M., Edison, Arthur S., McIntyre, Lauren M., and Fernández, Facundo M.

Abstract

Ion mobility (IM) spectrometry provides semiorthogonal data to mass spectrometry (MS), showing promise for identifying unknown metabolites in complex non-targeted metabolomics data sets. While current literature has showcased IM–MS for identifying unknowns under near ideal circumstances, less work has been conducted to evaluate the performance of this approach in metabolomics studies involving highly complex samples with difficult matrices. Here, we present a workflow incorporating de novomolecular formula annotation and MS/MS structure elucidation using SIRIUS 4 with experimental IM collision cross-section (CCS) measurements and machine learning CCS predictions to identify differential unknown metabolites in mutant strains of Caenorhabditis elegans. For many of those ion features, this workflow enabled the successful filtering of candidate structures generated by in silicoMS/MS predictions, though in some cases, annotations were challenged by significant hurdles in instrumentation performance and data analysis. While for 37% of differential features we were able to successfully collect both MS/MS and CCS data, fewer than half of these features benefited from a reduction in the number of possible candidate structures using CCS filtering due to poor matching of the machine learning training sets, limited accuracy of experimental and predicted CCS values, and lack of candidate structures resulting from the MS/MS data. When using a CCS error cutoff of ±3%, on average, 28% of candidate structures could be successfully filtered. Herein, we identify and describe the bottlenecks and limitations associated with the identification of unknowns in non-targeted metabolomics using IM–MS to focus and provide insights into areas requiring further improvement.

Published
2023
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248. List of Contributors

Author

Adamczick, Charlotte, Bastawrous, Andrew, Babji, Sudhir, Bates, M. Jane, Bausch, Daniel G., Beare, Nicholas A.V., Boelaert, Marleen, Burchard, Gerd-Dieter, Bustamante, Beatriz, Concha, Fátima, Currie, Bart, Dance, David, Dieckmann, Sebastian, Douangnoulak, Viravong, Ekem, Ivy, El-Dib, Nadia, Farrar, Jeremy, Fernández, Facundo M., Friedlander, Arthur M., Gotuzzo, Eduardo, Green, Michael D., Harries, Anthony D., Howlett, William P., Ignatius, Ralf, Inthalad, Saythong, Ishida, Kentaro, Jacquerioz, Frederique, Jeffs, Benjamin, Jordan, Sabine, Kang, Gagandeep, Katchanov, Juri, Keoluangkhot, Valy, Kluxen, Guido, Latthaphasavang, Vatthanaphone, Llanos-Cuentas, Alejandro, Mabey, David, Maguiña, Ciro, Martínez, Dalila, Maruyama, Haruhiko, Mayxay, Mayfong, McCarthy, James, Cordero, Fernando Mejía, Miller, Robert F., Molyneux, Elizabeth M., Morguet, Andreas J., Nawa, Yukifumi, Newton, Paul N., Nic Fhogartaigh, Caoimhe, Norindr, Buachan, van Oosterhout, Joep J., Pollach, Gregor, Postels, Douglas G., Premaratna, Ranjan, Rattanavong, Sayaphet, Ritmeijer, Koert, Rono, Hillary K., Roodnat, Karen, Rothe, Camilla, Seas, Carlos, Sey, Fredericka, Schneider, Thomas, Schulze Schwering, Markus, Siddiqi, Omar, Siebert, Eberhard, Sisouphonh, Siho, Slesak, Günther, Soukaloun, Douangdao, Srour, M. Leila, Stocker, Hartmut, Stojkovic, Marija, Tomita, Masaki, Verdonck, Kristien, Vogel, Moritz, Wall, Emma C., Weitzel, Thomas, Whitty, Christopher J.M., Woldeamanuel, Yohannes W., Woods, Katherine L., Wright, Mary E., and Yacoub, Sophie

Published
2014
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250. Front Cover: A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases (Chem. Eur. J. 39/2022).

Author

Menor‐Salván, César, Burcar, Bradley T., Bouza, Marcos, Fialho, David M., Fernández, Facundo M., and Hud, Nicholas V.

Subjects
PYRIMIDINE nucleosides, GUANINE, ORIGIN of life, PTERIDINES, INULIN
Abstract

Keywords: pterins; guanosine; origins of life; RNA world; phosphorylation EN pterins guanosine origins of life RNA world phosphorylation 1 1 1 07/13/22 20220711 NES 220711 B Guanosine and pterins are depicted as the constellation Gemini b . However, like Pollux from Greek mythology, guanosine would not have been born alone - pterins would have been formed in equal (or, in this case, even in major) parts through prebiotic reactions. Pterins, guanosine, origins of life, RNA world, phosphorylation. [Extracted from the article]

Published
2022
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