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Objective To research the effects of incorporating tetrapod-like zinc oxide whisker (T-ZnOw) of different proportions on the antibacterial activity of different kinds of soft denture liners. Methods The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of T-ZnOw against Saccharomyces albicans (S.albicans) were examined by the broth dilution test. Add T-ZnOw 0%, 1%, 2%, 3% to Silagum soft denture liners and soft denture liners respectively. The antimicrobial rate of S.albicans was determined by the membrane covering method. Results The MIC of T-ZnOw against S.albicans was 78 μg.mL-1 and the MBC was 156 μg.mL-1. Comparing 1%, 2%, 3% T-ZnOw group with control group, the results showed significant difference (P<0.05). And as the T-ZnOw antibacterial agent added ratio increased, antibacterial increased significantly. Conclusion The soft denture liners incorporating with 1%, 2%, 3% of T-ZnOw can improve antibacterial activity. Following the increased proportions of T-ZnOw, antibacterial rate was significantly increasing. [ABSTRACT FROM AUTHOR]

Fractal interpolation function (FIF) is continuous on its interval of definition. As a special kind of continuous function, FIFs' integrations on various scales and Fourier transform are studied in this paper. All of them can be expressed by the parameters of the corresponding iterative function systems. [ABSTRACT FROM AUTHOR]

In this paper, by using fractal curves, a family of fractal surfaces are defined. Each fractal surface of this family is called Star Product Fractal Surface (SPFS). A theorem of the dimensions of the SPFS is strictly proved. The relationship between the dimensions of the SPFS and the dimensions of the fractal curves constructing the SPFS is obtained. [ABSTRACT FROM AUTHOR]

Presents an asymptotic procedure to evaluate the tracer trajectory in a two-stream turbulent pipe mixing unit with an oblique branch. Areas where the problem of mixing two fluid streams by turbulent jet injection into a pipeline has various applications; Details on jet injection at an arbitrary angle; Conclusion.

Dendrite morphogenesis is essential for a neuron to establish its receptive field and is, thus, the anatomical basis for the proper functioning of the nervous system. The molecular mechanisms governing dendrite branching are not fully understood. Using the multi-dendritic PVD neuron in the nematode Caenorhabditis elegans , we identify CATP-8/P5A ATPase as a key regulator of dendrite branching that controls the translocation of the DMA-1 receptor to the endoplasmic reticulum (ER). The specific signal peptide of DMA-1 and the ATPase activity of CATP-8 are essential for this process. Our results reveal that P5A ATPase may regulate protein translocation in the ER. • P5A ATPase/CATP-8 is required for dendrite morphogenesis • CATP-8 regulates DMA-1 protein level by translocation into the endoplasmic reticulum • P5A ATPase function is evolutionarily conserved to regulate DMA-1 translocation • CATP-8 regulation of DMA-1 translocation is specific to the DMA-1 signal peptide Feng et al. reveal a role for the conserved P5A ATPase/CATP-8 in dendrite morphogenesis. CATP-8 controls the translocation of the DMA-1 receptor into the endoplasmic reticulum specifically through the DMA-1 signal peptide. This provides insights into the physiological and biochemical functions of P5A ATPases in metazoans. [ABSTRACT FROM AUTHOR]

Soil radon anomaly is a common phenomenon in karst areas. In this paper, the geochemical behavior of radium (Ra) in the process of carbonate rock weathering and soil formation was used to reveal the accumulation mechanism of soil radon. In the karst area and non-karst area, 24 soil points were collected to measure radon and radium, and a carbonate weathering profile was collected in the karst area. The research showed that: (1) the theoretical radon value obtained from Ra is far greater than the radon value measured on site, indicating that soil Ra can provide a potential source for the source of soil Rn; (2) through the study of the geochemical behavior of Ra during the weathering process, it was found that Ra was significantly enriched during carbonate weathering. This paper deepened the understanding of the geochemical behavior of radionuclides (Ra, Rn) in karst environments. [ABSTRACT FROM AUTHOR]

Na 5 Lu 9 F 32 single crystals co-doped with various Er 3+ /Yb 3+ concentrations were grown by an improved Bridgman method for the first time. The crystal structure is characterized by means of X-ray diffraction (XRD). High transmission in the range from 400 nm to 7150 nm and maximum phonon energy about 441 cm −1 for the Na 5 Lu 9 F 32 single crystals are obtained from the measured transmission and Raman spectra, respectively. The Judd-Ofelt parameters of Er 3+ in the obtained crystal was calculated and discussed according to the measured absorption spectra. Compared with the Er 3+ single-doped Na 5 Lu 9 F 32 crystal, an obviously enhanced emission band at 1500 nm was observed upon excitation of 980 nm laser diode (LD) via energy transfer from Yb 3+ to Er 3+ . Decay curve fitting using a Inokuti-Hirayama expression indicates dipole-dipole energy transfer from Yb 3+ to Er 3+ .The maximum emission cross section at ∼1.5 μm was also calculated to be 10.12 × 10 −20 cm 2 for the Na 5 Lu 9 F 32 single crystal of 1% Er 3+ and 6% Yb 3+ in molar fraction doping concentration. [ABSTRACT FROM AUTHOR]

The α-NaYF 4 single crystals doped with 0.2 mol%, 0.5 mol%, 1 mol%, 2 mol% and 3 mol% Er 3+ ions were fabricated by an improved Bridgman method. The ~1.5 µm and ~2.7 µm emission properties were investigated in detail through the measured absorption and emission spectra. A Judd–Ofelt analysis of Er 3+ in α-NaYF 4 samples is performed. The Judd–Ofelt parameters are obtained (Ω 2 =2.71×10 −20 cm 2 , Ω 4 =2.28×10 −20 cm 2 , Ω 6 =0.84×10 −20 cm 2 ) and the radiative lifetimes of Er 3+ energy levels and the branching ratios of Er 3+ transitions are calculated. The calculated maximum emission cross section by McCumber theory for ~1.5 µm and ~2.7 µm reached 1.35×10 −20 cm 2 and 2.2×10 −20 cm 2 , respectively. The gain cross section spectra were calculated based on the absorption and emission cross section spectra. All these spectral properties indicated that this kind of fluoride crystal has potential application as host material for infrared lasers. [ABSTRACT FROM AUTHOR]

In this study, a bibliometric analysis was performed to evaluate the global scientific production on oyster research from the period of 1991 to 2014. This analysis was based on the Science Citation Index Expanded database. A total of 11,493 publications were identified, and two main aspects were analysed: (1) publication performance and (2) research emphases and trends. The result indicated the annual publications on oyster study increased in number. The USA published the most papers in this field and was the most frequent partner in international collaborations. Pierre Boudry and Ximing Guo were the two most productive authors. The most productive institution was the French Research Institute for Exploitation of the Sea. The Journal of Shellfish Research and Aquaculture were two most productive journals. Analyses of author keywords suggested that 'growth' was the most frequently used term followed by 'aquaculture'. The major research areas related to oysters were 'growth, reproduction and mortality', 'abiotic factors', 'biotic factors', 'immunity', 'ecology', 'pollution', 'nutrition', 'aquaculture and food safety' and 'methods or technology'. Researches about ' Vibrio parahaemolyticus', 'norovirus', ' Ostreid herpesvirus 1', 'climate change', 'ocean acidification' and 'pH' have become increasingly more common. 'Proteomics', 'transcriptome' and 'ecosystem services' have been the new research topics in recent years. Overall, our findings may serve as an alternative way to learn about trends in oyster research and contribute to future investigations. [ABSTRACT FROM AUTHOR]

Mannose-binding lectin-associated serine protease 1 (MASP1) plays a crucial role in the complement lectin pathway and the mediation of immune responses. However, comprehensive research on MASP1 across various cancer types has not been performed to date. This study aimed to evaluate the significance of MASP1 in pan-cancer. The Cancer Genome Atlas (TCGA), UCSC Xena and Genotype Tissue Expression (GTEx) databases were used to evaluate the expression profiles, genomic features, prognostic relevance, and immune microenvironment associations of MASP1 across 33 cancer types. We observed significant dysregulation of MASP1 expression in multiple cancers, with strong associations between MASP1 expression levels and diagnostic value as well as patient prognosis. Mechanistic insights revealed significant correlations between MASP1 levels and various immunological and genomic factors, including tumor-infiltrating immune cells (TIICs), immune-related genes, mismatch repair (MMR), tumor mutation burden (TMB), and microsatellite instability (MSI), highlighting a critical regulatory function of MASP1 within the tumor immune microenvironment (TIME). In vitro and in vivo experiments demonstrated that MASP1 expression was markedly decreased in liver hepatocellular carcinoma (LIHC). Moreover, the overexpression of MASP1 in hepatocellular carcinoma (HCC) cell lines significantly inhibited their proliferation, invasion and migration. In conclusion, MASP1 exhibits differential expression in the pan-cancer analyses and might play an important role in TIME. MASP1 is a promising prognostic biomarker and a potential target for immunological research, particularly in LIHC. [Display omitted] • MASP1 expression is significantly different in multiple cancer types. • MASP1 is downregulated in HCC and the downregulation of MASP1 is associated with the poor prognosis of HCC patients. • MASP1 could inhibit HCC proliferation and metastasis via the ERK/p38 MAPK signaling pathway. • MASP1 was proposed to be a potential target for cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Ischemia–reperfusion injury (IRI) is a cumulation of pathophysiological processes that involves cell and organelle damage upon blood flow constraint and subsequent restoration. However, studies on overall immune infiltration and ferroptosis in liver ischemia-reperfusion injury (LIRI) are limited. This study explored immune cell infiltration and ferroptosis in LIRI using bioinformatics and experimental validation. The GSE151648 dataset, including 40 matched pairs of pre- and post- transplant liver samples was downloaded for bioinformatic analysis. Eleven hub genes were identified by overlapping differentially expressed genes (DEGs), iron genes, and genes identified through weighted gene co-expression network analysis (WGCNA). Subsequently, the pathway enrichment, transcription factor-target, microRNA-mRNA and protein-protein interaction networks were investigated. The diagnostic model was established by logistic regression, which was validated in the GSE23649 and GSE100155 datasets and verified using cytological experiments. Moreover, several drugs targeting these genes were found in DrugBank, providing a more effective treatment for LIRI. In addition, the expression of 11 hub genes was validated using quantitative real-time polymerase chain reaction (qRT-PCR) in liver transplantation samples and animal models. The expression of the 11 hub genes increased in LIRI compared with the control. Five genes were significantly enriched in six biological process terms, six genes showed high enrichment for LIRI-related signaling pathways. There were 56 relevant transcriptional factors and two central modules in the protein-protein interaction network. Further immune infiltration analysis indicated that immune cells including neutrophils and natural killer cells were differentially accumulated in the pre- and post-transplant groups, and this was accompanied by changes in immune-related factors. Finally, 10 targeted drugs were screened. Through bioinformatics and further experimental verification, we identified hub genes related to ferroptosis that could be used as potential targets to alleviate LIRI. • We identified eleven hub genes related to ferroptosis in LIRI. • A promising diagnostic model was consturcted and verified. • We explored the relationship between immune infiltration and hub genes in LIRI. • Ten potential drugs were identified that target the hub genes. [ABSTRACT FROM AUTHOR]

Although a large number of Triassic magmatism were found in the Qiangtang terrane, central Tibet, the tectonic evolution of the Shuanghu Palaeo‐Tethys Ocean remains controversial. In this study, we present the zircon U–Pb age and major‐ and trace‐element data for the Late Triassic pluton from the Cairi area in the eastern Qiangtang terrane. Zircon U–Pb dating indicates that the samples were emplaced at ca. 230 Ma. The magmatism from the Cairi area primarily consists of granites (SiO2 = 67.28–77.74), with the characteristics of medium‐K calc‐alkaline, metaluminous, and peraluminous. The Cairi granites are enriched light rare earth elements ([La/Yb]N = 5.01–10.56), with obvious Eu anomaly (Eu/Eu* = 0.32–0.47). The Cairi granites are characterized by low 1,000 × Ga/Al (2.10–2.64), FeO*/MgO (3.41–5.03), Ce (57.95–114.36 ppm), Y (27.30–45.19 ppm), and negative correlation between P2O5 and SiO2. These geochemical features reveal that the Cairi granites are calc‐alkaline, I‐type granites. The four samples show relatively restricted (87Sr/86Sr)i ratios (0.70598–0.70724), 143Nd/144Nd ratios (0.51192–0.51196), and εNd(t) of −8.19 to −7.54. Based on the variations of Rb–Sr–Ba and Th–La–Nb and the zircon saturation of temperatures (806–868°C), we suggest that the primary magmas of the Cairi granites were generated through various degrees of mixing between sediments and mantle‐derived components. Petrological and geochemical characteristics, as well as regional geological characteristics indicate that the Cairi granites formed in a continental volcanic arc setting. Our results, in combination with the coeval granites and elcogite, indicate that the generation of Late Triassic (ca. 230 Ma) Cairi granites is related to ocean ridge subduction and subsequent development of a slab window. [ABSTRACT FROM AUTHOR]

Abstract: The dynamic mechanical analysis (DMA) was applied to investigate the damping properties of Mg–Ca binary alloys both at room and elevated temperatures. The results show the as-cast Mg–1wt%Ca binary alloy exhibits good damping capacities, which could be of a potential candidate for damping magnesium alloys. The Ca has greatly effect on the damping properties of Mg–Ca alloys. In addition, the damping measurement of Mg–1wt%Ca alloy with increasing temperature has also been carried out. The damping mechanisms were also discussed. [Copyright &y& Elsevier]

Designs a left ventricular assist device with impeller pump and brushless motor compacted in one unit to assist the blood circulation of an experimental calves. Creation of a ceramic bearing and a purge system through the bearing; Schematic diagram of the of the device; Implantation of diaphragm pump according to the systole of the natural heart.

The Jilinbaolige polymetallic deposit, located in the Dong Ujimqin Banner in Inner Mongolia, China, belongs to the Daxinganling and Nangebi-Dongwu Banner polymetallic metallogenic belts. In recent years, many medium to large Ag-Pb-Zn deposits have been discovered, but due to their deep burial and the Quaternary soils cover, mineral exploration is difficult. In order to investigate the relationship among the mineralization, rock body and tectonic structures in the study region, we implemented 5.57 km2 magnetic exploration and four audio-magnetotelluric survey lines with 184 exploration points. Through comprehensive geophysical and geological inference and interpretation, we identified two types of granite which were formed at different stages in the early Yanshanian period, and inferred the NNE F4, NW F5 and NW F6 faults as the ore-conducting and ore-hosting structures of the Ag-Pb-Zn deposits. We determined that the faults' intersections provide the main metallogenic spaces while also locating concealed rock bodies interspersed as small stocks or veins within the upper Devonian Anguinwula formation. Apparently the Ag-Pb-Zn deposits are closely related to subsequently intrusive monzonitic granites of the early Yanshanian period. As confirmed by drilling, many Ag-Pb-Zn ore veins are found at 550–600 m depths and monzonitic granite porphyries at 750 m depth. Our geophysical exploration results reveal the coupling relationship between the concealed rock bodies and metallogenic structures, which can provide direction and effective geophysical methods to prospect for potentially similar deposits in the surrounding area. • Comprehensive geophysical and geological methods were used to investigate metallogenic regularity. • Two types of Yanshanian granites, exhibiting strong and weak magnetism, have been detected. • Results show that Ag-Pb-Zn mineralization is closely related to strongly magnetic granite. • Coupling relationship was found between concealed a rock body and metallotectonics. • Methods for seeking analogous deposits in the study region are proposed. [ABSTRACT FROM AUTHOR]

Background: Biejiaruangan capsule (BJRGC) is a commonly used traditional Chinese medicine preparation for treating oftreating liver fibrosis (LF), but its specific molecular mechanism is unclear. This study used mass spectrometry, network pharmacology and experimental verification to explore the mechanism of BJRGC against LF., Methods: Ultrahigh-performance liquid chromatography-quadrupole-exactive-orbitrap-mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS) and network pharmacology were employed to identify and screen the potential components, targets, and signaling pathways of BJRGC against LF. The interaction between the active ingredients and targets was validated using molecular docking. Finally, 5-ethynyl-2'-deoxyuridine (EDU) staining, western blotting (WB), and flow cytometry (FCM) were utilized to further verify the mechanism of BJRGC against LF., Results: A total of 9 prototype components of BJRGC were identified in serum, most derived from iridoid glycosides and triterpenes in Gardenia jasminoides Ellis and Artemisia scoparia Waldst.et Kit. Network pharmacology predicts that medicine prototype components in serum mostly influence targets such as CDK2, CDK6, and PIK3CG, with the key route being the PI3K/AKT signaling pathway. Molecular docking showed that the major components have good binding properties with key target proteins. The experimental results showed that BJRGC could inhibit the proliferation of HSCs, induce cell cycle arrest and reduce the protein expression of CDK2, CDK6 and PIK3CG., Conclusions: BJRGC can inhibit the proliferation of HSCs by targeting the protein expression of CDK2, CDK6, and PIK3CG in the PI3K/AKT signaling pathway through its prototype components, such as hyperoside, tumulosic acid, and hederagenin, thereby alleviating LF disease., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide, and the identification of novel treatment targets and prognostic biomarkers is urgently needed because of its unsatisfactory prognosis. Regulator of G-protein signaling 19 (RGS19) is a multifunctional protein that regulates the progression of various cancers. However, the specific function of RGS19 in HCC remains unclear. The expression of RGS19 was determined in clinical HCC samples. Functional and molecular biology experiments involving RGS19 were performed to explore the potential mechanisms of RGS19 in HCC. The results showed that the expression of RGS19 is upregulated in HCC tissues and is significantly associated with poor prognosis in HCC patients. RGS19 promotes the proliferation and metastasis of HCC cells in vitro and in vivo. Mechanistically, RGS19, via its RGS domain, stabilizes the MYH9 protein by directly inhibiting the interaction of MYH9 with STUB1, which has been identified as an E3 ligase of MYH9. Moreover, RGS19 activates β-catenin/c-Myc signaling via MYH9, and RGS19 is also a transcriptional target gene of c-Myc. A positive feedback loop formed by RGS19, MYH9, and the β-catenin/c-Myc axis was found in HCC. In conclusion, our research revealed that competition between RGS19 and STUB1 is a critical mechanism of MYH9 regulation and that the RGS19/MYH9/β-catenin/c-Myc feedback loop may represent a promising strategy for HCC therapy., (© 2024. The Author(s).)

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer whose incidence and mortality continue to increase, whereas its prognosis remains dismal. Tumor-associated macrophages (TAMs) promote malignant progression and immune microenvironment remodeling through direct contact and secreted mediators. Targeting TAMs has emerged as a promising strategy for ICC treatment. Here, we revealed the potential regulatory function of immune responsive gene 1 (IRG1) in macrophage polarization. We found that IRG1 expression remained at a low level in M2 macrophages. IRG1 overexpression can restrain macrophages from polarizing to the M2 type, which results in inhibition of the proliferation, invasion, and migration of ICC, whereas IRG1 knockdown exerts the opposite effects. Mechanistically, IRG1 inhibited the tumor-promoting chemokine CCL18 and thus suppressed ICC progression by regulating STAT3 phosphorylation. The intervention of IRG1 expression in TAMs may serve as a potential therapeutic target for delaying ICC progression., (© 2024 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)

N6-Methyladenosine (m 6 A) plays key roles in the regulation of biological functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs. However, little is known about the underlying mechanisms of m 6 A-modified mRNAs in hepatic IR injury. In mouse models, liver samples were subjected to methylated RNA immunoprecipitation with high-throughput sequencing (MeRIP-seq) and RNA sequencing (RNA-seq). In total, 16917 m 6 A peaks associated with 4098 genes were detected in the sham group, whereas 21,557 m 6 A peaks associated with 5322 genes were detected in the IR group. There were 909 differentially expressed m 6 A peaks, 863 differentially methylated transcripts and 516 differentially m 6 A modification genes determined in both groups. The distribution of m 6 A peaks was especially enriched in the coding sequence and 3'UTR. Furthermore, we identified a relationship between differentially m 6 A methylated genes (fold change≥1.5/≤ 0.667, p value≤0.05) and differentially expressed genes (fold change≥1.5 and p value≤0.05) to obtain three overlapping predicted target genes (Fnip2, Phldb2, and Pcf11). Our study revealed a transcriptome-wide map of m 6 A mRNAs in hepatic IR injury and might provide a theoretical basis for future research in terms of molecular mechanisms.

Background: The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which are affected by transmembrane proteins localized in the ER membrane. One such protein, transmembrane protein 147 (TMEM147), has recently been implicated for its role in hepatocellular carcinoma (HCC) tumorigenesis; however, the mechanisms remain unclear. We investigated the role of TMEM147 in HCC and the underlying mechanisms., Methods: TMEM147 expression was examined in human HCC cells and adjacent non-tumorous tissues using quantitative reverse transcription-polymerase chain reaction, western blotting, and immunohistochemistry. In vitro and in vivo studies were conducted to investigate the impact of TMEM147 on the progression of HCC. Proteins interacting with TMEM147 were identified via RNA-seq, immunoprecipitation, and mass spectrometry analyses. Lipidomic analysis and enzyme-linked immunosorbent assay (ELISA) were employed to determine and analyze cholesterol and 27-hydroxycholesterol (27HC) contents. Extensive experimental techniques were used to study ferroptosis in HCC cells. The fatty acid content of macrophages affected by TMEM147 was quantified using ELISA. Macrophage phenotypes were determined using immunofluorescence assay and flow cytometric analysis., Results: TMEM147 mRNA and protein levels were increased in HCC cells, and the increased TMEM147 expression was associated with a poor survival. TMEM147 promoted tumor cell proliferation and metastases in vitro and in vivo. The protein was found to interact with the key enzyme 7-dehydrocholesterol reductase (DHCR7), which affected cellular cholesterol homeostasis and increased the extracellular levels of 27HC in HCC cells. TMEM147 also promoted the expression of DHCR7 by enhancing the activity of signal transducer and activator of transcription 2. 27HC expression upregulated glutathione peroxidase 4 in HCC, leading to ferroptosis resistance and promotion of HCC proliferation. HCC cell-derived 27HC expression increased the lipid metabolism in macrophages and activated peroxisome proliferator-activated receptor-γ signaling, thereby activating M2 macrophage polarization and promoting HCC cell invasion and migration., Conclusions: Our results indicate that TMEM147 confers ferroptosis resistance and M2 macrophage polarization, which are primarily dependent on the upregulation of cellular cholesterol homeostasis and 27HC secretion, leading to cancer growth and metastasis. These findings suggest that the TMEM147/STAT2/DHCR7/27HC axis in the tumor microenvironment may serve as a promising therapeutic target for HCC., (© 2023. The Author(s).)

Hepatocellular carcinoma (HCC) is one of the most deadly malignant cancers worldwide. Research into the crucial genes responsible for maintaining the aggressive behaviour of cancer cells is important for the clinical treatment of HCC. The purpose of this study was to determine whether the E3 ubiquitin ligase Ring Finger Protein 125 (RNF125) plays a role in the proliferation and metastasis of HCC. RNF125 expression in human HCC samples and cell lines was investigated using TCGA dataset mining, qRT‒PCR, western blot, and immunohistochemistry assays. In addition, 80 patients with HCC were studied for the clinical value of RNF125. Furthermore, the molecular mechanism by which RNF125 contributes to hepatocellular carcinoma progression was determined with mass spectrometry (MS), coimmunoprecipitation (Co-IP), dual-luciferase reporter assays, and ubiquitin ladder assays. We found that RNF125 was markedly downregulated in HCC tumour tissues, which was associated with a poor prognosis for patients with HCC. Moreover, the overexpression of RNF125 inhibited HCC proliferation and metastasis both in vitro and in vivo, whereas the knockdown of RNF125 exerted antithetical effects. Mechanistically, mass spectrometry analysis revealed a protein interaction between RNF125 and SRSF1, and RNF125 accelerated the proteasome-mediated degradation of SRSF1, which impeded HCC progression by inhibiting the ERK signalling pathway. Furthermore, RNF125 was detected to be the downstream target of miR-103a-3p. In this study, we identified that RNF125 is a tumour suppressor in HCC and inhibits HCC progression by inhibiting the SRSF1/ERK pathway. These findings provide a promising treatment target for HCC., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)