680 results on '"Fauser B."'
Search Results
202. The role of the endometrium and embryo in human implantation.
- Author
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Diedrich, K., Fauser, B. C. J. M., Devroey, P., and Griesinger, G.
- Subjects
- *
ENDOMETRIUM , *ENDOMETRIOSIS , *FEMALE reproductive organ diseases , *EMBRYO transfer , *REPRODUCTIVE technology - Abstract
The article outlines the current understanding of implantation in humans and the role the endometrium and embryo play in the process. It also identifies key areas in implantation research and methodology that need to be focused on in the future such as optimizing ovarian stimulation regimens, the timing of human chorionic gonadotrophin injection or the timing of embryo transfer, to help increase implantation rates. Also cited are the strengths and limitations of morphological and immunohistochemistry assessments of endometrial receptivity.
- Published
- 2007
- Full Text
- View/download PDF
203. In Vitroandin VivoBioactivity of Recombinant Human Follicle-Stimulating Hormone and Partially Deglycosylated Variants Secreted by Transfected Eukaryotic Cell Lines*
- Author
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GALWAY, A. BRENDA, primary, HSUEH, AARON J. W., additional, KEENE, J. L., additional, YAMOTO, M., additional, FAUSER, B. C. J. M., additional, and BOIME, IRVING, additional
- Published
- 1990
- Full Text
- View/download PDF
204. BIOACTIVE AND IMMUNOREACTIVE FSH IN SERUM OF NORMAL AND OLIGOSPERMIC MEN
- Author
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FAUSER, B. C. J. M., primary, BOGERS, J. W., additional, HOP, W. C. J., additional, and JONG, F. H., additional
- Published
- 1990
- Full Text
- View/download PDF
205. Gonadotrophins in ovulation induction.
- Author
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Macklon, N. S. and Fauser, B. C. J. M.
- Subjects
- *
GONADOTROPIN , *PITUITARY hormones , *OVULATION , *DRUG dosage , *MULTIPLE pregnancy , *IMMUNOLOGICAL adjuvants , *REPRODUCTIVE technology - Abstract
For anovulatory women who fail to ovulate or conceive with clomiphene citrate, gonadotrophin ovulation induction has been the conventional second-line therapy. The aim of treatment is to achieve monofollicular development and ovulation. This differs fundamentally from the aim of ovarian stimulation for IVF, in which multiple follicular development is the goal. The small therapeutic window of ovulation induction requires a rigorous approach to monitoring, and willingness to cancel the cycle when multiple follicle development occurs. The two most widely used approaches are the low-dose step-up and the step-down protocols. While the latter more closely mimics the normo-ovulaloiy cycle, outcomes are similar. For safety reasons, the step-down protocol has not been widely adopted. The principle risks of ovulation induction are ovarian hyperstimulation syndrome and multiple pregnancy. There is a need to individualize treatment if outcomes are to be optimized. The role of adjuvant therapies remains unclear. However, prediction models based on initial screening parameters enable the optimal dose of FSH to be determined, and the identification of patients with a poor prognosis for successful treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
206. Das Garmischer Modell f�r die Behandlung von�Schmerzpatienten in der Kinder- und Jugendrheumatologie.
- Author
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Richter, M, H�fner, R, Schurer, A, Spamer, M, Fischer, K, and Fauser, B
- Published
- 2004
- Full Text
- View/download PDF
207. Induction of Multiple Follicular Development by a Single Dose of Long-Acting Recombinant Follicle-Stimulating Hormone (FSH-CTP, Corifollitropin Alfa) for Controlled Ovarian Stimulation before in Vitro Fertilization.
- Author
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DEVROEY, P., FAUSER, B. C., PLATTEAU, P., BECKERS, N. G., DHONT, M., and MANNAERTS, B. M.
- Published
- 2004
- Full Text
- View/download PDF
208. Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen–thawed embryos followed by analysis of the remaining embryo on day 5.
- Author
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Baart, E. B., Opstal, D. Van, Los, F. J., Fauser, B. C. J. M., and Martini, E.
- Subjects
MOSAICISM ,EMBRYOS ,GENETIC disorder diagnosis ,ANEUPLOIDY ,FLUORESCENCE in situ hybridization - Abstract
BACKGROUND: Chromosomal mosaicism in human embryos may give rise to false positive or false negative results in preimplantation genetic diagnosis for aneuploidy screening (PGD‐AS). Therefore, we have investigated whether the results obtained from a 2‐cell biopsy of frozen–thawed embryos and fluorescence in situ hybridization (FISH) analysis are representative for the chromosome constitution of the remaining embryo on day 5. METHODS: Cryopreserved day 3 embryos were thawed and from surviving embryos two blastomeres were biopsied. FISH analysis was performed for chromosomes 1, 7, 13, 15, 16, 18, 21, 22, X and Y. After biopsy, the embryos were cultured until day 5 and further analysed using the same probe panels. RESULTS: In all, 17 embryos were available with a diagnosis based on two blastomeres on day 3 and confirmatory studies on day 5. In 10 of these 17 cases the initial diagnosis could be confirmed. However, in only six cases cytogenetic results were concordant. Besides the 10 cases with a ‘correct’ diagnosis, there were six false positive results and one false negative, all involving mosaicism. CONCLUSIONS: Investigating the chromosomal constitution of two blastomere nuclei offers a good opportunity to study the incidence of chromosomal mosaicism in early embryo development. The confirmation rate of the results obtained on day 3 depends on the interpretation and is higher when considered from a clinical than from a cytogenetic point of view. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
209. Characteristics of the Best Prognostic Evidence: An Example on Prediction of Outcome after Clomiphene Citrate Induction of Ovulation in Normogonadotropic Oligoamenorrheic Infertility.
- Author
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Eijkemans, M. J.C., Habbema, J. D.F., and Fauser, B. C.J.M.
- Published
- 2003
- Full Text
- View/download PDF
210. Absent biologically relevant associations between serum inhibin B concentrations and characteristics of polycystic ovary syndrome in normogonadotrophic anovulatory infertility.
- Author
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Laven, Joop S. E., Imani, Babek, Eijkemans, Marinus J. C., de Jong, Frank H., Fauser, Bart C. J. M., Laven, J S, Imani, B, Eijkemans, M J, de Jong, F H, and Fauser, B C
- Abstract
Background: Dominant follicle selection is disturbed in normogonadotrophic anovulatory infertility [World Health Organization (WHO) 2] and remaining early antral follicles are either healthy or atretic. This study was conducted to investigate whether inhibin B serum concentrations (produced by healthy small antral follicles) represent the extent of ovarian abnormalities in WHO 2 women and patients with polycystic ovarian syndrome (PCOS), constituting a subgroup of WHO 2 patients.Methods and Results: Ultrasonographic and endocrine characteristics in 379 WHO 2 patients and 30 normo-ovulatory controls were compared. In the WHO 2 patients, the PCOS subgroup and the controls, inhibin B concentrations were similar. Inhibin B concentrations were weakly but significantly correlated with the total number of ovarian follicles (r = 0.282; P < 0.001), LH (r = 0.347; P < 0.001), and testosterone (r = 0.269; P < 0.001) but not with serum oestradiol concentrations (r = 0.057). Most (71%) patients with elevated inhibin B also presented with increased concentrations of LH and/or hyperandrogenaemia. In a subgroup of 190 subjects, classified as PCOS based on hyperandrogenaemia and polycystic ovaries, elevated inhibin B concentrations were found in 23% of cases. Aforementioned correlations were similar in PCOS as in WHO 2 patients.Conclusion: In conclusion, inhibin B serum concentrations are normal in WHO 2 and PCOS women, suggesting a normal number of healthy early antral follicles despite increased overall follicle numbers in PCOS. [ABSTRACT FROM AUTHOR]- Published
- 2001
- Full Text
- View/download PDF
211. Regulation of follicle development and novel approaches to ovarian stimulation for IVF.
- Author
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Macklon, N. S. and Fauser, B. C. J. M.
- Abstract
Current ovarian stimulation regimens for IVF are complex and not without risk. Increasing our knowledge of the physiology of follicle development and dominant follicle selection may enable the design of less complex, safer and cheaper ovarian stimulation regimens for IVF. Decremental serum FSH concentrations during the follicular phase of the menstrual cycle are required for single dominant follicle selection. Only the most mature follicle will continue its development due to increased sensitivity for stimulation by FSH. FSH stimulation becomes insufficient for less mature follicles and remaining cohort follicles will therefore go into atresia. The number of days during which FSH is above the threshold for stimulation of follicle development is limited, resulting in a narrow FSH window. More medium sized and large pre-ovulatory follicles and increased oestradiol output can be induced by the administration of small doses of exogenous FSH during the mid- to late follicular phase, preventing the physiological decrease in FSH stimulation. Intervention with decremental serum FSH concentrations in combination with gonadotrophin-releasing hormone (GnRH) antagonists to prevent a premature rise in serum LH may induce ongoing growth of multiple follicles sufficient for IVF. The benefits and risks of these minimal hyperstimulation protocols require further evaluation. [ABSTRACT FROM PUBLISHER]
- Published
- 2000
- Full Text
- View/download PDF
212. Single monthly administration of the anti-progestagen Org 31710 in users of the 75 microg desogestrel progestagen-only pill: effects on pituitary-ovarian activity.
- Author
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van Heusden, A M, Killick, S R, Coelingh Bennink, H J, and Fauser, B C
- Subjects
OVARIAN physiology ,PITUITARY gland physiology ,CLINICAL trials ,COMPARATIVE studies ,DRUG administration ,ENDOMETRIUM ,ESTRADIOL ,FOLLICLE-stimulating hormone ,HETEROCYCLIC compounds ,HORMONE antagonists ,LUTEINIZING hormone ,RESEARCH methodology ,MEDICAL cooperation ,ORAL contraceptives ,OVARIES ,OVULATION ,PITUITARY gland ,PLACEBOS ,PROGESTERONE ,RESEARCH ,STEROIDS ,EVALUATION research ,RANDOMIZED controlled trials ,BLIND experiment - Abstract
Endocrine and ultrasound effects were studied of an intermittent (every 28 days) oral administration of 150 mg of the anti-progestagen Org 31710 during the continued daily use of 75 microg desogestrel (DSG) for progestagen-only contraception. A randomized, double-blind, placebo-controlled two-centre study was conducted in 50 healthy volunteers. Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), oestradiol and progesterone concentrations, and follicle number and size were studied, as well as endometrial thickness, which was assessed by transvaginal sonography at least twice weekly during a single medication cycle (cycle 3-5). Forty-eight women were evaluated (Org 31710, n = 25; placebo, n = 23). Seven ovulations were observed in the treated group versus none in the placebo group. LH concentrations were higher on days 9 and 11 and oestradiol concentrations lower on day 3 in the treated group, irrespective of whether ovulation occurred. No parameter could predict ovulation. Endometrial thickness was greater on cycle days 7-13 and 19 in the treated group. However, within the Org 31710 group, no significant differences were found in volunteers who did or did not ovulate. Observed differences may be attributed to a competitive effect of Org 31710 with progestagen-induced suppression of the pituitary-ovarian axis, altered oestradiol feedback mechanisms, and/or altered receptor availability. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
213. Follicular and luteal phase characteristics following early cessation of gonadotrophin-releasing hormone agonist during ovarian stimulation for in-vitro fertilization.
- Author
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Beckers, N G, Laven, J S, Eijkemans, M J, and Fauser, B C
- Abstract
Gonadotrophin-releasing hormone agonists (GnRHa) are widely used in in-vitro fertilization (IVF) for the prevention of a premature rise in luteinizing hormone (LH) concentrations. However, the administration of GnRHa during the follicular phase may also impair subsequent luteal function due to retarded recovery of pituitary gonadotrophin secretion. Therefore, luteal supplementation is generally applied. The present study was designed to determine whether a premature LH surge would still be prevented after early cessation of GnRHa during ovarian stimulation and whether subsequent luteal phase LH production would be sufficient to support progesterone synthesis by the corpus luteum. Sixty patients were randomized for three groups: (i) A long GnRHa/human menopausal gonadotrophin (HMG) protocol with luteal support by repeated human chorionic gonadotrophin (HCG) (n = 20), (ii) early follicular phase cessation of GnRHa without luteal support (n = 20), and (iii) a long GnRHa protocol without luteal support (n = 20). Frequent ultrasound and blood sampling was performed during the entire IVF cycle. Forty normo-ovulatory women served as controls. No premature LH surges were found after early cessation of GnRHa. In this group, some pituitary recovery occurred during the late luteal phase, but this did not affect corpus luteum function. Progesterone concentrations were shown to be dependent on disappearance of the pre-ovulatory bolus of HCG. Pregnancies occurred in all three groups. In conclusion, early follicular phase cessation of GnRHa is still effective in the prevention of a premature rise in LH. Although some pituitary recovery was observed thereafter, corpus luteum function is still abnormal due to early luteolysis. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
214. Minimal ovarian stimulation for IVF: appraisal of potential benefits and drawbacks.
- Author
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Fauser, B C, Devroey, P, Yen, S S, Gosden, R, Crowley, W F Jr, Baird, D T, and Bouchard, P
- Subjects
OVARIAN physiology ,EMBRYO transfer ,FERTILIZATION in vitro ,FOLLICLE-stimulating hormone ,INDUCED ovulation ,RESEARCH funding - Published
- 1999
- Full Text
- View/download PDF
215. The relation between clinical manifestations of polycystic ovary syndrome and β-cell function.
- Author
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Weber, R. F. A., Pache, T. D., Jacobs, M. L., Doctor, R., Loriaux, D. Lynn, Fauser, B. C. J. M., and Birkenhäger, J. C.
- Published
- 1993
- Full Text
- View/download PDF
216. Gonadotrophin induction of ovulation using a step-down dose regimen: single-centre clinical experience in 82 patients.
- Author
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van Santbrink, E J, Donderwinkel, P F, van Dessel, T J, and Fauser, B C
- Subjects
CHORIONIC gonadotropins ,CLINICAL trials ,COMPARATIVE studies ,DRUG resistance ,FOLLICLE-stimulating hormone ,GONADOTROPIN ,INFERTILITY ,LUTEINIZING hormone releasing hormone ,RESEARCH methodology ,MEDICAL cooperation ,INDUCED ovulation ,RESEARCH ,TIME ,EVALUATION research ,RANDOMIZED controlled trials ,CLOMIPHENE ,PHARMACODYNAMICS - Abstract
A total of 82 normogonadotrophic clomiphene-resistant anovulatory patients were treated with exogenous gonadotrophins according to a step-down dose regimen during 234 cycles. In 43 (18%) cycles co-treatment with gonadotrophin-releasing hormone analogues was applied. The initial dose was between 1.5 and 2.5 ampoules (75 IU follicle-stimulating hormone each) per day (dependent on body weight), and decreasing steps of 0.5 ampoules/day were based on sonographic findings. The overall ovulation rate was 91% (213 cycles). The median treatment period was 11 days and a total of 14 ampoules of gonadotrophin were needed. In 131 (62%) of the ovulatory cycles not more than one, and in 208 (98%) cycles not more than two, follicles > or = 16 mm were present on the day human chorionic gonadotrophin was given. A total of 37 pregnancies occurred of which two were twins and one was a triplet (multiple pregnancy rate 8%). The pregnancy rate per cycle was 17% and the cumulative pregnancy rate after 7 months was 47%. The abortion rate was 19%. There were four (1.7%) cases of mild ovarian hyperstimulation, of which none became pregnant. In conclusion, this study shows that the applied step-down regimen for gonadotrophin induction of ovulation can be a safe and effective treatment alternative for patients with clomiphene-resistant anovulation. The duration of ovarian stimulation and the amount of exogenous gonadotrophin required is limited. Pregnancy rates are comparable with those reported for step-up regimens, and a low incidence of complications (i.e. multiple gestation and ovarian hyperstimulation) was noted.(ABSTRACT TRUNCATED AT 250 WORDS) [ABSTRACT FROM AUTHOR]
- Published
- 1995
217. Genetic basis of human reproductive endocrine disorders.
- Author
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Fauser, B C and Hsueh, A J
- Subjects
COMPARATIVE studies ,ENDOCRINE diseases ,HUMAN reproduction ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,EVALUATION research - Abstract
Disturbed human reproductive function may be caused by environmental and/or genetic factors. Much information related to single gene defects underlying reproductive failure has become available in recent years due to advances in molecular biology. In this review, techniques currently applied for deoxyribonucleic acid (DNA) analysis are addressed. We also highlight underlying molecular mechanisms and the corresponding clinical presentation of single gene defects affecting (i) the hypothalamic-pituitary-gonadal axis, resulting in disturbed gonadotrophin-releasing hormone (GnRH) neuron migration, or leading to defective gonadotrophins, gonadotrophin receptors and the Gs alpha protein; (ii) gonadal and adrenal steroid biosynthesis and (iii) steroid and insulin receptors. The potential genetic basis of polycystic ovary syndrome is also discussed. Although disease states caused by well-defined genetic abnormalities appear to represent only a small proportion of those found in the patient population, it should be considered that these affected individuals represent only the most severe cases in a wide spectrum of genetic abnormalities underlying disturbed fertility. Comprehension of these extreme cases will provide the basis for the elucidation of more common reproductive disorders as the result of subtle genetic changes or increased susceptibility to environmental factors. [ABSTRACT FROM AUTHOR]
- Published
- 1995
218. Recombinant human follicle-stimulating hormone and ovarian response in gonadotrophin-deficient women.
- Author
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Schoot, D C, Harlin, J, Shoham, Z, Mannaerts, B M, Lahlou, N, Bouchard, P, Bennink, H J, and Fauser, B C
- Abstract
Seven women suffering from hypogonadism due to previous hypophysectomy, isolated gonadotrophin deficiency, or Kallman's syndrome [median age 39 years (range 24-45)] volunteered to participate in a study to assess ovarian response following multiple-dose administration of recombinant human follicle-stimulating hormone (rhFSH; Org 32489). Baseline serum FSH and luteinizing hormone (LH) concentrations were 0.25 (< 0.05-1.15) IU/l and 0.06 (< 0.05-0.37) IU/l, respectively. Subjects received daily i.m. injections of rhFSH for 3 weeks (week 1: 75 IU/day, week 2: 150 IU/day, week 3: 225 IU/day). Blood sampling and sonographic investigations were performed on alternate days. Steady-state FSH concentrations were reached approximately 3-5 days after alterations of the doses administered. Maximum FSH concentrations were between 7.1 and 11.8 IU/l, whereas serum LH concentrations remained unchanged. Due to absent follicle development and lack of a rise in immunoreactive inhibin (INH) (response failure possibly due to early ovarian failure or resistant ovary syndrome) in two subjects, analysis of ovarian response was restricted to five volunteers. Serum androstenedione levels showed no significant changes during rhFSH administration. Although serum immunoreactive INH concentrations reached normal late follicular values [659 (388-993) IU/l], serum oestradiol revealed only a minor increase [77 (18-210) pmol/l]. Moreover, growth of (multiple) ovarian follicles was observed up to pre-ovulatory sizes (> 15 mm) in these patients.(ABSTRACT TRUNCATED AT 250 WORDS) [ABSTRACT FROM AUTHOR]
- Published
- 1994
219. Development of a human granulosa cell culture model with follicle stimulating hormone responsiveness.
- Author
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Schipper, I, Fauser, B C, van Gaver, E B, Zarutskie, P W, and Dahl, K D
- Abstract
In order to study the effects of follicle-stimulating hormone (FSH) on differentiation of granulosa cells, a well-defined and validated in-vitro culture system is indispensable. In this study, pooled follicular aspirates were stimulated in vitro with FSH and luteinizing hormone (LH) for 2, 4 and 6 days, either immediately after plating or after 7 days of preincubation. Cultures were assayed for progesterone and oestradiol production. Fresh cells displayed very high basal progesterone production which could be stimulated with LH but not FSH. After preincubation, addition of LH and FSH resulted in dose-dependent increases of progesterone and oestradiol. When cultured on human fibronectin-coated wells, similar basal but higher progesterone concentrations after stimulation were observed. In comparison with serum-free media, addition of Serum-Plus resulted in higher basal and stimulated progesterone concentration, possibly due to the presence of serum factors. This study demonstrates firstly that after 7 days preincubation, cultures gained responsiveness to FSH but remained responsive to LH during 4 days of stimulation. This suggests a persisting differentiated cell population in vitro. Secondly, the use of human fibronectin extracellular matrix and serum promotes steroid production, either due to factors promoting cell growth and function or to availability of steroid precursors. Therefore one has to be cautious with interpretation of data obtained from this widely used culture system, employing highly differentiated cells obtained after ovarian stimulation for in-vitro fertilization for study of local regulation of granulosa cell function. [ABSTRACT FROM AUTHOR]
- Published
- 1993
220. Antimullerian hormone serum levels: a putative marker for ovarian aging
- Author
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Vet, A. de, Laven, J. S., Jong, F. H. de, Themmen, A. P., and Fauser, B. C.
- Published
- 2002
- Full Text
- View/download PDF
221. Child development and quality of parenting in lesbian families: no psychosocial indications for a-priori withholding of infertility treatment. A systematic review.
- Author
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Hunfeld, J A M, Fauser, B C J M, de Beaufort, I D, and Passchier, J P
- Abstract
Among fertility centres, much discussion focuses on whether to withhold infertility treatment from special patient groups (lesbians, prospective single parent(s), prospective parent(s) of relatively advanced age, or with severe diseases) because it is assumed that this is in the best interest of the child. The present study aimed to establish whether there is any empirical evidence for this assumption. A literature search was made in PubMed/Medline and PsycINFO to identify studies that had assessed psychological outcomes of children and quality of parenting after infertility treatment. Eight studies met the following inclusion criteria: published in an English-language peer-reviewed journal between 1978 and 2002, and focused on psychosocial child development and quality of parenting after infertility treatment in the above-mentioned special patient groups. All reviewed studies focused on lesbian or single-parent families. Overall, the methodological quality of studies as assessed by a standardized set of criteria was high. The evidence of the studies (assessed by the best evidence synthesis method) was strong for the conclusion that in lesbian families the psychosocial development of children (median age 6.1 years) and the quality of parenting are not different from those in healthy heterosexual two-parent families after infertility treatment or natural conception. Therefore, withholding infertility treatment from lesbian families on the assumption that such intervention may not be in the interest of the prospective child seems unjustified. For the other special patient groups, no conclusions could be drawn, because of a lack of relevant studies.
- Published
- 2002
- Full Text
- View/download PDF
222. Conception to ongoing pregnancy: the 'black box' of early pregnancy loss.
- Author
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Macklon, N S, Geraedts, J P M, and Fauser, B C J M
- Abstract
Even when conditions are optimal, the maximum chance of a clinically recognized pregnancy occurring in a given menstrual cycle is 30-40%. Increasing evidence points to preclinical pregnancy loss rather than failure of conception as the principal cause for the relatively low fecundity observed in humans. While sensitive assays for hCG have provided a glimpse of the events occurring between implantation and the missed menstrual period, new cytogenetic techniques have further opened this 'black box', providing novel insights into the causes of early pregnancy wastage. In this article, the evidence and causes of preclinical or 'occult' pregnancy are reviewed, and the implications for the infertile patient are addressed.
- Published
- 2002
- Full Text
- View/download PDF
223. Residual ovarian activity during oral steroid contraception.
- Author
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van Heusden, A M and Fauser, B C J M
- Abstract
Steroid drugs with contraceptive properties have been available in the clinical setting for over four decades and are still subject to improvement. Estrogens, progestins and anti-progestins have been used alone or in various combinations, regimens and routes of administration to favour the balance between efficacy and undesirable effects. One of the most important changes in this respect is the gradual lowering of steroid dosage in commercially available contraceptives. Current steroid contraceptive pills still achieve the goal of suppression of pituitary-ovarian activity, but the margins for error are minimal. In this review the available data on modes of action and the effects on suppressing pituitary-ovarian activity by different forms of oral contraception are reassessed. Although pregnancy rates provide a crude measure of contraceptive efficacy, no benchmark for pituitary-ovarian inhibition is available to test the suppressive potential of contraceptive drugs. Consequently, many studies provide incomplete and/or incomparable results. For the further study of those forms of steroid contraception that rely predominantly on suppression of ovarian activity, prevention of dominant follicles selection should be the objective.
- Published
- 2002
- Full Text
- View/download PDF
224. Follicle-Stimulating Hormone and Advanced Follicle Development in the Human
- Author
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Macklon, N. S. and Fauser, B. C. J. M.
- Published
- 2001
- Full Text
- View/download PDF
225. Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon)
- Author
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Jong, D. de, Macklon, N. S., Eijkemans, M. J., Mannaerts, B. M., Bennink, H. J. Coelingh, and Fauser, B. C.
- Published
- 2001
- Full Text
- View/download PDF
226. A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the follicle-stimulating hormone window combined with the gonadotropin-releasing hormone antagonist cetrorelix
- Author
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Jong, D. de, Macklon, N. S., and Fauser, B. C.
- Published
- 2000
- Full Text
- View/download PDF
227. Regulation of follicle development and novel approaches to ovarian stimulation for IVF.
- Author
-
Smacklon, N and Fauser, B C
- Abstract
Current ovarian stimulation regimens for IVF are complex and not without risk. Increasing our knowledge of the physiology of follicle development and dominant follicle selection may enable the design of less complex, safer and cheaper ovarian stimulation regimens for IVF. Decremental serum FSH concentrations during the follicular phase of the menstrual cycle are required for single dominant follicle selection. Only the most mature follicle will continue its development due to increased sensitivity for stimulation by FSH. FSH stimulation becomes insufficient for less mature follicles and remaining cohort follicles will therefore go into atresia. The number of days during which FSH is above the threshold for stimulation of follicle development is limited, resulting in a narrow FSH window. More medium sized and large pre-ovulatory follicles and increased oestradiol output can be induced by the administration of small doses of exogenous FSH during the mid- to late follicular phase, preventing the physiological decrease in FSH stimulation. Intervention with decremental serum FSH concentrations in combination with gonadotrophin-releasing hormone (GnRH) antagonists to prevent a premature rise in serum LH may induce ongoing growth of multiple follicles sufficient for IVF. The benefits and risks of these minimal hyperstimulation protocols require further evaluation.
- Published
- 2000
- Full Text
- View/download PDF
228. Increased loss of trabecular but not cortical bone density, 1 year after discontinuation of 2 years hormone replacement therapy with Tibolone
- Author
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Berning, B., Kuijk, C. V., Kuiper, J. W., Bennink, H. J. Coelingh, and Fauser, B. C.
- Published
- 1999
- Full Text
- View/download PDF
229. What is the most relevant standard of success in assisted reproduction? The next step to improving outcomes of IVF: consider the whole treatment.
- Author
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Heijnen, E. M. E. W., Macklon, N. S., and Fauser, B. C. J. M.
- Published
- 2004
- Full Text
- View/download PDF
230. Effects of Two Doses of Tibolone on Trabecular and Cortical Bone Loss in Early Postmenopausal Women: A Two-Year Randomized, Placebo-Controlled Study
- Author
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Berning, B., Kuijk, C. V., Kuiper, J. W., Bennink, Coelingh, T., H. J., Kicovic, P. M., and Fauser, B. C. J. M.
- Published
- 1996
- Full Text
- View/download PDF
231. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain
- Author
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. 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A., Rothstein, T. L., Gibson, J. M., Morrison, P. M., Collins, A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni, S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Fiore, Del, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis, B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. 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M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., and Donato, M.
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- 1994
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232. Insulin-like growth factors and insulin-like growth factor binding proteins in androgen-dominant ovarian follicles from testosterone-treated female-to-male trans-sexuals
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Yap, O. W. S., Dessel, Van, T., H. J. H. M., Chandrasekher, Y. A., Fauser, B. C. J. M., and Giudice, L. C.
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- 1997
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233. Classification of normogonadotropic infertility: polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome
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Santbrink, E. J. P. Van, Hop, W. C., and Fauser, B. C. J. M.
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- 1997
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234. Developmental and endocrine aspects of normal ovarian aging
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Velde, E. R. Te, Scheffer, G. J., Dorland, M., Broekmans, F. J., and Fauser, B. C. J. M.
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- 1998
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235. Expression of Biologically Active Human Follitropin in Chinese Hamster Ovary Cells
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Keene, J L, Matzuk, M M, Otani, T, Fauser, B C, Galway, A B, Hsueh, A J, and Boime, I
- Abstract
To study the structure-function relationships of follitropin (FSH), we expressed the hormone in a heterologous cell system. A genomic clone bearing a 3.7-kilobase FSHβ insert containing the entire coding sequence was transfected alone or together with the α subunit gene into Chinese hamster ovary cells and stable lines expressing either FSHβ or FSH dimer were selected. Pulse-chase experiments revealed that, when transfected alone FSHβ was very slowly secreted similar to lutropin β and thyrotropin β but unlike choriogonadotropin β which is efficiently secreted. However, cotransfection of the FSHβ and α subunit genes resulted in “rescue” of the β subunit and rapid secretion of dimer. These data support the hypothesis that the glycoprotein hormones of pituitary origin have determinants for secretion that differ from those on the placental hormone, choriogonadotropin. Recombinant FSH stimulated steroidogenesis comparable to purified human FSH isolated from pituitaries in an in vitrorat granulosa cell assay and appears more homogeneous by chromatofocusing. Human FSH produced by this cell line provides a source of bioactive FSH for experimental and clinical use.
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- 1989
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236. Luteal function following ovulation induction in polycystic ovary syndrome patients using exogenous gonadotrophins in combination with a gonadotrophin-releasing hormone agonist.
- Author
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Donderwinkel, P F, Schoot, D C, Pache, T D, de Jong, F H, Hop, W C, and Fauser, B C
- Abstract
The luteal phase was studied in 12 polycystic ovary syndrome (PCOS) patients following ovulation induction using exogenous gonadotrophins combined with a gonadotrophin-releasing hormone agonist (GnRH-a). Human menopausal gonadotrophin (HMG) was preceded by 3 weeks of treatment with GnRH-a (buserelin; 1200 micrograms/day intra-nasally) and administered in a step-down dose regimen starting with 225 IU/day i.m. GnRH-a was withheld the day before administration of human chorionic gonadotrophin (HCG; 10,000 IU i.m.). Blood sampling and ultrasound monitoring was performed every 2-3 days until menses. The luteal phase was significantly shorter in PCOS patients as compared to eight regularly cycling controls: 8.8 (3.3-11.4) days [median(range)] versus 12.8 (8.9-15.9) days (P = 0.01). Median peak values for progesterone did not show significant differences comparing both groups: 52.3 (17.1-510.3) nmol/l versus 43.0 (31.2-71.1) nmol/l, respectively (P = 0.8). The interval between the day of the progesterone peak and return to baseline was significantly shorter in the PCOS patients than in controls: 2.5 (0.3-4.9) days versus 4.2 (3.9-10.5) days (P < 0.005). Luteinizing hormone (LH) concentrations during the luteal phase as reflected by area under the curve were significantly lower in PCOS as compared to controls: 4.4 (1.6-21.0) IU/l x days and 49.0 (27.8-79.6) IU/l x days, respectively (P < 0.001). In conclusion, patients with PCOS may suffer from insufficient luteal phases after ovulation induction using HMG/HCG in combination with a GnRH-a. The corpus luteum apparently lacks the support of endogenous LH and may be stimulated only by the pre-ovulatory injection of HCG.(ABSTRACT TRUNCATED AT 250 WORDS)
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- 1993
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237. Follicle development during the normal menstrual cycle
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Macklon, N. S. and Fauser, B. C. J. M.
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- 1998
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238. Recombinant follicle-stimulating hormone (FSH; Puregon) is more efficient than urinary FSH (Metrodin) in women with clomiphene citrate-resistant, normogonadotropic, chronic anovulation: a prospective, multicenter, assessor-blind, randomized, clinical trial
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Bennink, Coelingh, T., H. J., Fauser, B. C. J. M., and Out, H. J.
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- 1998
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239. The Dirichlet Hopf algebra of arithmetics
- Author
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Fauser, B, Jarvis, PD, Fauser, B, and Jarvis, PD
- Abstract
Many constructs in mathematical physics entail notational complexities, deriving from the manipulation of various types of index sets which often can be reduced to labelling by various multisets of integers. In this work, we develop systematically the "Dirichlet Hopf algebra of arithmetics" by dualizing the addition and multiplication maps. Then we study the additive and multiplicative antipodal convolutions which fail to give rise to Hopf algebra structures, but form only a weaker Hopf gebra obeying a weakened homomorphism axiom. A careful identification of the algebraic structures involved is done featuring subtraction, division and derivations derived from coproducts and chochains using branching operators. The consequences of the weakened structure of a Hopf gebra on cohomology are explored, showing this has major impact on number theory. This features multiplicativity versus complete multiplicativity of number theoretic arithmetic functions. The deficiency of not being a Hopfalgebra is then cured by introducing an "unrenormalized" coproduct and an "unrenormalized" pairing. It is then argued that exactly the failure of the homomorphism property (complete multiplicativity) for non-coprime integers is a blueprint for the problems in quantum field theory (QFT) leading to the need for renormalization. Renormalization turns out to be the morphism from the algebraically sound Hopf algebra to the physical and number theoretically meaningful Hopf gebra (literally: antipodal convolution). This can be modelled alternatively by employing Rota–Baxter operators. We stress the need for a characteristic-free development where possible, to have a sound starting point for generalizations of the algebraic structures. The last section provides three key applications: symmetric function theory, quantum (matrix) mechanics, and the combinatorics of renormalization in QFT which can be discerned as functorially inherited from the development at the number-theoretic level as outlined he
240. The Dirichlet Hopf algebra of arithmetics
- Author
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Fauser, B, Jarvis, PD, Fauser, B, and Jarvis, PD
- Abstract
Many constructs in mathematical physics entail notational complexities, deriving from the manipulation of various types of index sets which often can be reduced to labelling by various multisets of integers. In this work, we develop systematically the "Dirichlet Hopf algebra of arithmetics" by dualizing the addition and multiplication maps. Then we study the additive and multiplicative antipodal convolutions which fail to give rise to Hopf algebra structures, but form only a weaker Hopf gebra obeying a weakened homomorphism axiom. A careful identification of the algebraic structures involved is done featuring subtraction, division and derivations derived from coproducts and chochains using branching operators. The consequences of the weakened structure of a Hopf gebra on cohomology are explored, showing this has major impact on number theory. This features multiplicativity versus complete multiplicativity of number theoretic arithmetic functions. The deficiency of not being a Hopfalgebra is then cured by introducing an "unrenormalized" coproduct and an "unrenormalized" pairing. It is then argued that exactly the failure of the homomorphism property (complete multiplicativity) for non-coprime integers is a blueprint for the problems in quantum field theory (QFT) leading to the need for renormalization. Renormalization turns out to be the morphism from the algebraically sound Hopf algebra to the physical and number theoretically meaningful Hopf gebra (literally: antipodal convolution). This can be modelled alternatively by employing Rota–Baxter operators. We stress the need for a characteristic-free development where possible, to have a sound starting point for generalizations of the algebraic structures. The last section provides three key applications: symmetric function theory, quantum (matrix) mechanics, and the combinatorics of renormalization in QFT which can be discerned as functorially inherited from the development at the number-theoretic level as outlined he
241. Endocrinology. High doses of gonadotrophin-releasing hormone antagonist in in-vitro fertilization cycles do not adversely affect the outcome of subsequent freeze–thaw cycles
- Author
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Kol, S., Lightman, A., Hillensjo, T., Devroey, P., Fauser, B., Tarlatzis, B., Mannaerts, B., and Itskovitz-Eldor, J.
- Abstract
The clinical application of gonadotrophin-releasing hormone (GnRH) antagonists instead of GnRH agonists, to prevent spontaneous premature luteinizing hormone surge during ovarian stimulation for assisted reproduction treatment has been advocated. A recent, double-blind, dose-finding study, including six dosages of the GnRH antagonist ganirelix, in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (FSH), has indicated that high doses of GnRH antagonist (1 or 2 mg once daily) are associated with a low implantation rate. This follow-up study reports on the pregnancy rate after replacement of cryopreserved embryos obtained in stimulation cycles of the above-mentioned trial. Ovarian stimulation was initiated on day 2 of the cycle, with daily injections of 150 IU recombinant FSH. Ganirelix (0.0625, 0.125, 0.25, 0.5, 1.0 or 2.0 mg) was administered once daily from stimulation day 6 onwards, up to and including the day of human chorionic gonadotrophin. Retrieved oocytes were fertilized by in-vitro fertilization (IVF) or intracytoplasmic sperm injection and a maximum of three fresh embryos was transferred. Excess embryos were frozen, and subsequently used in either natural or programmed cycles. Until June 1998, 11 ongoing pregnancies (12–16 weeks after embryo transfer) were achieved from 46 cycles in which embryos had been first frozen (23.9% per transfer). Six of these 11 patients had been treated with a high dose of ganirelix (1.0 or 2.0 mg) during the IVF cycles in which the embryos were obtained. In conclusion, our data suggest that high dosages of ganirelix do not adversely affect the potential of embryos to establish clinical pregnancy in freeze–thaw cycles.
- Published
- 1999
242. The Significance of Fragile X Mental Retardation Gene 1 CGG Repeat Sizes in the Normal and Intermediate Range in Women With Primary Ovarian Insufficiency.
- Author
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Voorhuis, M., Onland-Moret, N. C., Janse, F., van Amstel, H. K. Ploos, Goverde, A. J., Lambalk, C. B., Laven, J. S. E., van der Schouw, Y. T., Broekmans, F. J. M., and Fauser, B. C. J. M.
- Published
- 2014
- Full Text
- View/download PDF
243. First established pregnancy and birth after induction of ovulation with recombinant human follicle-stimulating hormone in polycystic ovary syndrome.
- Author
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van Dessel, H.J.H.M., Donderwinkel, P.F.J., Coelingh, H.J.T., Fauser, B.C.J.M., van Dessel, H J, Donderwinkel, P F, Coelingh Bennink, H J, and Fauser, B C
- Abstract
This case report describes the first established pregnancy and birth after induction of ovulation with recombinant human follicle-stimulating hormone (FSH) in a woman suffering from chronic clomiphene-resistant anovulation due to polycystic ovary syndrome (elevated serum luteinizing hormone and testosterone concentrations together with polycystic ovaries). Starting on day 3 of a progestagen withdrawal bleeding, 75 IU of rFSH was administered i.m. daily until a single preovulatory follicle was seen upon transvaginal ultrasound examination at day 13. Ovulation was induced by a single i.m. administration of 10,000 IU of human chorionic gonadotrophin, after which a viable singleton pregnancy was revealed at a gestational age of 6 weeks. The course of pregnancy and labour was uneventful and no abnormalities were found upon a paediatric examination. [ABSTRACT FROM AUTHOR]
- Published
- 1994
244. Follicle pool depletion: factors involved and implications
- Author
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Fauser, B. C.
- Published
- 2000
- Full Text
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245. A patient-centred approach to IVF stimulation.
- Author
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Fauser, B. C. J. M
- Subjects
- *
FERTILIZATION in vitro , *PREGNANCY - Abstract
The history of IVF has been characterized by profound ovarian stimulation protocols, in an attempt to optimise pregnancy rates per cycle. These approaches, aiming at generating as many oocytes as possible, were meant to counterbalance shortcomings in in-vitro oocyte fertilization, embryo culture conditions, as well as embryo selection for transfer. Another reason often put forward to justify profound stimulation is the cryostorage of surplus embryos, providing additional pregnancy chances in subsequent unstimulated cycles. Over the years ovarian stimulation protocols have become extremely complex and time consuming, associated with much patient discomfort and considerable complication rates. Moreover, costs of applied medication may outweigh the cost of IVF treatment itself. High doses of exogenous gonadotrophins are usually combined with extended suppression of endogenous pituitary function using GnRH agonist. In many centres, ovarian stimulation is preceded by the suppression of ovarian function using steroid contraceptives, aiming at 'synchronizing' follicle development and also for logistic reasons. Consequently, ovarian stimulation usually takes 1 to 2 months, and associated patient discomfort and cost are substantial. Moreover, much time is required in between IVF cycles to allow for the ovary to recover, and patient drop-out rates are high even in countries where IVF is reimbursed. The stimulation of numerous dominant follicles increases chances for the rare but dangerous ovarian hyperstimulation syndrome, the retrieval of many oocytes may be more time consuming and painful, the large oocyte numbers generated may potentially affect oocyte quality (and related aneuploidy rates of embryos). Moreover, abnormal follicular phase endocrinology associated with multiple dominant follicle development may give rise to decreased endometrial receptivity (reducing pregnancy chances). Finally, the true benefit of embryo cryostorage remains limited. The aim of milder forms of ovarian stimulation is to render stimulation less complex, less time consuming and less costly while improving patient acceptability by reducing side effects. This may result in the improvement of the cost effectiveness of IVF (hopefully resulting in augmented access to IVF) and may also reduce drop-out rates. These women may be exposed to additional chances to achieve a pregnancy in subsequent IVF cycles. Only in this context can mild ovarian stimulation be appreciated, since the overall pregnancy rate for a given IVF cycle will be slightly reduced (especially in case where mild ovarian stimulation is combined with the transfer of a single embryo). Therefore, the concept of mild ovarian stimulation (just like the transfer of a single embryo) can only be developed further in a holistic perspective of IVF, involving healthy children as primary outcome, in the context of overall patient discomfort, chances for complications and cost per IVF treatment over a given period of time (which may involve multiple IVF cycles). The introduction of GnRH antagonists into the clinic (where the period of administration can be restricted to the period at risk for a premature LH rise) allowed for an IVF cycle to commence with a physiological recruitment of a limited number of follicles in the beginning of the cycle, as occurs under normal conditions. Therefore, the use of GnRH antagonists has facilitated the further development of mild stimulation applying low doses of exogenous FSH during the mid- to late-follicular phase aiming to interfere with single dominant follicle selection. Initial proof of principle studies by our group has further explored this concept. Subsequently, a large effectiveness trial comparing a mild (mild stimulation along with single embryo transfer) with a conventional approach has been performed showing similar cumulative term live birth rates at lower cost, less patient discomfort, reduced drop-out rates and a dramatic reduction in multiple pregnancies. Moreover, it has been shown that mild ovarian stimulation is associated with a reduced proportion of aneuploid embryos as assessed by preimplantation genetic screening. [ABSTRACT FROM AUTHOR]
- Published
- 2008
246. The Relation Between Clinical Manifestations of Polycystic Ovary Syndrome and βCell Function
- Author
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Weber, R. F. A., Pache, T. D., Jacobs, M. L., Docter, R., Loriaux, D. Lynn, Fauser, B. C. J. M., and Birkenhager, J. C.
- Published
- 1993
247. The feasibility of a less invasive method to assess endometrial maturation--comparison of simultaneously obtained uterine secretion and tissue biopsy.
- Author
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van der Gaast M, Macklon N, Beier-Hellwig K, Krusche C, Fauser B, Beier H, Classen-Linke I, van der Gaast, M H, Macklon, N S, Beier-Hellwig, K, Krusche, C A, Fauser, B C J M, Beier, H M, and Classen-Linke, I
- Abstract
Objective: To compare the assessment of endometrial maturation parameters in endometrial secretion samples obtained by a novel minimally invasive technique with those assessed in tissue biopsies.Design: Prospective study.Setting: University Hospital.Population: Healthy female volunteers attending a gynaecological outpatient clinic.Methods: Endometrial secretion fluid and tissue sampling 5 days after a spontaneous ovulation assessed with ultrasound.Main Outcome Measures: Progesterone (P) receptor, Ki-67 expression and the Noyes criteria were used to date endometrial biopsies. In the endometrial fluid samples, glycodelin A (GdA), leukaemia inhibitory factor (LIF) and P levels were analysed, and protein content and electrophoresis patterns were determined.Results: All data were correlated to estradiol (E2) and P serum concentrations. The dating according to histology and immunohistochemical staining patterns correlated significantly with GdA levels (r=0.376, P=0.048) in endometrial fluid samples as well with serum levels of E2 (r=0.568, P=0.001) and P (r=0.408, P=0.023). No correlation was observed between tissue dating and LIF levels and protein content in endometrial fluid samples.Conclusions: The measurement of GdA in endometrial secretion samples may provide a less invasive method for assessing endometrial maturation in potential conception cycles without disrupting implantation. [ABSTRACT FROM AUTHOR]- Published
- 2009
- Full Text
- View/download PDF
248. FSH and ovarian response: spontaneous recovery of pituitary–ovarian activity during the pill-free period vs . exogenous recombinant FSH during high-dose combined oral contraceptives.
- Author
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van Heusden, A. M, Coelingh Bennink, H. J. T, and Fauser, B. C. J. M
- Subjects
- *
PITUITARY gland , *FOLLICLE-stimulating hormone , *LUTEINIZING hormone - Abstract
Summary ojbective Compare spontaneous recovery of pituitary–ovarian activity during the pill-free period following the correct use of low-dose oral contraceptives and subsequent ovarian function during the administration of exogenous recombinant FSH (recFSH) after switching to continued Lyndiol® (2·5 mg lynestrenol + 0·05 mg ethinyl-oestradiol) medication. design Prospective, randomized, group-comparative, single-centre study. Following the monitoring of the pill-free period (week 1) and subsequent treatment with Lyndiol® (for a total of 5 weeks), all subjects were randomly allocated to one of four groups receiving daily FSH injections for 1 week [75, 150, 225 IU recFSH or 150 IU purified urinary FSH (uFSH)] during the fourth week of Lyndiol® use. patients Thirty-six healthy volunteers aged 18–39 years, prestudy oral contraceptive use for at least 3 months, cycle length between 24 and 35 days. measurements Serum FSH, LH and oestradiol (E2 ) concentrations as well as transvaginal ultrasound assessment of the number and diameter of follicles > 2 mm were used to monitor pituitary ovarian function. results At the start of the pill-free period following the prestudy contraceptive medication, 67% of the women presented with LH and FSH levels < 1 IU/l and only one follicle > 10 mm was observed. Initial levels of LH and FSH correlated (P < 0·05) with the extent of pituitary–ovarian activity during the pill-free period. At the end of the pill-free period a follicle > 10 mm had emerged in one subject only. During the first 3 days of Lyndiol® use, seven women (19%) eventually showed at least one follicle > 10 mm. During combined exogenous FSH and Lyndiol® administration, LH levels remained completely suppressed (≤ 0·5 IU/l) in all women studied. FSH levels and number and size of follicles increased with increasing doses of exogenous... [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
249. Fair allocation of cryopreserved donor oocytes: towards an accountable process.
- Author
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Kool, E M, Graaf, R van der, Bos, A M E, Fauser, B C J M, Bredenoord, A L, and van der Graaf, R
- Subjects
- *
MEDICAL personnel , *TREATMENT effectiveness , *SUPPLY & demand , *OVUM , *PARENTHOOD , *RESEARCH , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *OVUM donation , *COMPARATIVE studies , *RESOURCE allocation , *SOCIAL responsibility - Abstract
A growing number of people desire ART with cryopreserved donor oocytes. The allocation of these oocytes to couples and mothers to be is a 2-fold process. The first step is to select a pool of recipients. The second step is to decide who should be treated first. Prioritizing recipients is critical in settings where demand outstrips supply. So far, the issue of how to fairly allocate cryopreserved donor oocytes has been poorly addressed. Our ethical analysis aims to support clinics involved in allocation decisions by formulating criteria for recipient selection irrespective of supply (Part I) and recipient prioritization in case supply is limited (Part II). Relevant criteria for recipient selection are: a need for treatment to experience parenthood; a reasonable chance for successful treatment; the ability to safely undergo an oocyte donation pregnancy; and the ability to establish a stable and loving relationship with the child. Recipients eligible for priority include those who: have limited time left for treatment; have not yet experienced parenthood; did not undergo previous treatment with cryopreserved donor oocytes; and contributed to the supply of donor oocytes by bringing a donor to the bank. While selection criteria function as a threshold principle, we argue that the different prioritization criteria should be carefully balanced. Since specifying and balancing the allocation criteria undoubtedly raises a moral dispute, a fair and legitimate allocation process is warranted (Part III). We argue that allocation decisions should be made by a multidisciplinary committee, staffed by relevant experts with a variety of perspectives. Furthermore, the committees' reasoning behind decisions should be transparent and accessible to those affected: clinicians, donors, recipients and children born from treatment. Insight into the reasons that underpin allocation decisions allows these stakeholders to understand, review and challenge decisions, which is also known as accountability for reasonableness. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
250. The ethics of embryo donation: what are the moral similarities and differences of surplus embryo donation and double gamete donation?
- Author
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Huele, E H, Kool, E M, Bos, A M E, Fauser, B C J M, and Bredenoord, A L
- Subjects
- *
GAMETES , *EMBRYOS , *SOUND art , *FAMILIES , *ETHICS , *DISCLOSURE , *GERM cells , *OVUM donation , *HUMAN reproductive technology - Abstract
Over the years, the demand for ART with donated embryos has increased. Treatment can be performed using donated 'surplus embryos' from IVF treatment or with embryos intentionally created through so-called 'double gamete donation'. Embryo donation is particularly sensitive because treatment results in the absence of a genetic link between the parent(s) and the child, creating complex family structures, including full genetic siblings living in another family in the case of surplus embryo donation. In this paper, we explore the ethical acceptability of embryo donation in light of the similarities and differences between surplus embryo donation and double gamete donation. We will argue that no overriding objections to either form of embryo donation exist. First of all, ART with donated embryos respects patients' reproductive autonomy by allowing them to experience gestational parenthood. It also respects IVF patients' reproductive autonomy by providing an additional option to discarding or donating surplus embryos to research. Second, an extensive body of empirical research has shown that a genetic link between parent and child is not a condition for a loving caring relationship between parent(s) and child. Third, the low moral status of a pre-implantation embryo signifies no moral duty for clinics to first use available surplus embryos or to prevent the development of (more) surplus embryos through double gamete donation. Fourth, there is no reason to assume that knowledge of having (full or half) genetically related persons living elsewhere provides an unacceptable impact on the welfare of donor-conceived offspring, existing children of the donors, and their respective families. Thus, patients and clinicians should discuss which form of ART would be suitable in their specific situation. To guarantee ethically sound ART with donated embryos certain conditions have to be met. Counselling of IVF patients should involve a discussion on the destination of potential surplus embryos. When counselling donors and recipient(s) a discussion of the significance of early disclosure of the child's mode of conception, the implications of having children raised in families with whom they share no genetic ties, expectations around information-exchange and contact between donor and recipient families or genetically related siblings is warranted. Importantly, conclusions are mainly drawn from results of empirical studies on single gamete donation families. To evaluate the welfare of families created through surplus embryo donation or double gamete donation additional empirical research on these particular families is warranted. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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