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Early detection and rapid diagnosis of diseases have drawn much attention in today’s medical practice. Many diseases such as cancer may have a high chance of full recovery if detected at early stages. Breath analysis has received extensive interests because of its non-invasive nature as a highly feasible solution for individual or clinic’s practice of preventive medicine. Conventional gas analysis methods require examining the gas samples in the laboratory using either a gas chromatography-mass spectrometry (GC-MS) analyzer or a Fourier infrared spectrometer (FT-IR). Although GC-MS and FTIR offer relatively accurate results, they do not suit for monitoring an individual’s daily life since these instruments are bulky and the procedure is time-consuming. A light-weight device with fast and accurate detection is therefore ideal for gas analysis in detecting breath. The electronic nose (e-nose) offers an alternative for gas identification. The e-nose uses an array of sensors to acquire the specific response pattern for each type of gas and identifies this specific pattern for disease identification. The e-nose has recently been widely adopted for diagnosis, including dermal drugs, lung cancer, kidney disease, reproduction medication, diabetes, and asthma. Although e-noses are available in the market, the current products are still not popular owing to its massive volume and high cost regarding personal healthcare applications. This talk will introduce the development of miniaturized gas sensing circuits and systems based on e-nose principle. This enables real-time monitoring and rapid diagnosis of diseases. Gas sensors, interface circuits, system architecture, algorithms will be discussed.

Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is a new treatment for pleural infection. Clinical experiences of tPA/DNase therapy, and its complications, are cumulating. We present a patient with multiloculated empyema but no initial evidence of a bronchopleural fistula. She was treated with antibiotics and chest tube drainage of the basal collection through which four doses of tPA/DNase were delivered with success. The lateral collection worsened necessitating separate tube drainage and tPA/DNase treatment. She reported chest “fullness” when instilled the second dose. The third instillation of tPA triggered immediate vigorous coughing and expectoration of salty‐tasting fluid, likely the tPA/saline solution. The symptoms spontaneously settled after 15 min, with no evidence of air leak. The loculated fluid was successfully evacuated. The patient made a full recovery after an antibiotic course with no long‐term consequences. Pulmonary migration of drugs via a bronchopleural communication, although rare, can occur with intrapleural tPA/DNase therapy., Pulmonary migration of intrapleural drugs via a bronchopleural communication is a rare and poorly described complication of intrapleural tissue plasminogen activator/deoxyribonuclease (tPA/DNase) therapy. We report the first detailed case of a bronchopleural communication after intrapleural tPA/DNase instillation. Despite this, the patient made an uneventful recovery from the pleural infection without requiring surgical drainage.

Blunt traumatic cardiac rupture is an uncommon event in trauma and survival is rare. While multiple isolated accounts of repair of blunt cardiac rupture have been reported in the literature, there is not a single report of survival from right ventricular rupture following an emergency department thoracotomy (EDT). We report 2 cases where patients have survived such injuries and have made a full recovery. These patients are from a single institution who lost pulses on arrival to the emergency department; then underwent EDT with relief of cardiac tamponade with hemorrhage control by temporary closure, and subsequent definitive repair of right ventricular rupture in the operating room. Both were multiply injured and survived to discharge without neurologic sequelae and have made a full recovery back to their baseline function. This setting may represent an important use of EDT among blunt trauma patients, where time to survival and recovery may dependent on the speed of hemorrhage control and return of cardiac activity.

A 31 year old man with a past medical history of hyperthyroidism presented to the hospital in thyroid storm and cardiogenic shock. He was found to be in severe biventricular failure and with the use of biventricular impella support had a full recovery without significant comorbidity.

Venous leg ulcers are difficult-to-heal wounds. Reduction of venous hypertension and eradication of oedema is of key importance in the treatment of clinical symptoms of venous hypertension and venous leg ulcers. This can be done by using compression therapy in which external pressure is applied to the skin surface, giving a positive effect on the venous, lymphatic and arterial systems of macro- and microcirculation.Analysis of full recovery predicted time for venous ulcers.The purpose of our study was to rate the intermittent pneumatic compression (IPC) therapy in venous leg ulcers treatment. In the study group, the IPC therapy (pressure of 60 mm Hg at the ankle) was used - one treatment daily for 4 weeks. The changes of the total area, circumference, maximum length and maximum width of ulcers were measured. Then, based on the collected values, we calculated healing progress (Gilman index), healing rate, predicted healing time and non-linear approximation of the treatment time needed to decrease the ulcer surface area by 50% and then we compared them the treatment times.Analysis of the results shows that a percentage change in the surface area in the treatment group was 52%. There was a statistically significant difference between the ulcer surface area before and after treatment (Treatment of venous leg ulcers with the IPC therapy is effective.

Previous studies examining life after traumatic brain injury (TBI) have taken a predominantly short-term and quantitative perspective, with generally narrow focus, and have not specifically investigated changes in experience over time post-injury to gain a uniquely long-term perspective. This study therefore aimed to qualitatively explore the broad long-term experience of living for 10 years or more with TBI. Thirty participants completed semi-structured interviews investigating the impact of TBI on various life domains, the rehabilitation experience and support received, and overall perspectives of the long-term journey after TBI. Results demonstrated that: (a) although some participants reported full recovery, several experienced persistent physical, cognitive and emotional problems that impacted their independence, employment and interpersonal relationships; (b) early rehabilitation was very helpful, but some participants experienced difficulties accessing ongoing services; (c) family and social support were important to recovery; (d) most participants drew upon inner strength to find positives in their experience. These findings have identified factors that facilitate and impede long-term recovery from TBI, which may inform better support and care for injured individuals over the years after injury to improve their quality of life.

Background Urinary stones are the most common cause of acute ureteral obstruction. The homeopathic medicine Thlaspi bursa pastoris (TBP) has many symptoms similar to the typical symptoms of urolithiasis, yet its clinical usefulness has not been well documented. Patients In this study, the clinical symptoms of each of five patients, along with ultrasonographic evidence, were taken for the assessment of the outcome. TBP was prescribed in potency 30c and/or 200c to each patient on the basis of the main symptoms, typically dysuria, retention of urine and haematuria. Each case was followed for up to 6 months. Assessment of causal attribution of treatment effect was performed using the Modified Naranjo Criteria. Results There was full recovery of all five patients and post-treatment ultrasonography showed no calculi remaining. The Modified Naranjo Criteria total score for each patient was either +8/13 or +9/13. Conclusion TBP was observed to be effective in eliminating renal stones within a short span of time and without any complications.

This paper examines the impacts of hurricanes on the housing market and the associated implications for local population turnover. We first characterize the post-hurricane equilibrium dynamics in local housing markets using microdata from Florida during 2000-2016. Our results show that hurricanes cause an increase in equilibrium prices and a concurrent decrease in transactions in affected areas, both lasting up to three years. Together, these dynamics imply a negative transitory shock to the housing supply as a consequence of the hurricane. Furthermore, we match buyer characteristics from mortgage applications to provide the first buyer-level evidence on population turnover. We find that incoming homeowners in this period have higher incomes, leading to an overall shift in the local economic profile toward higher-income groups. Our findings suggest that market responses to destructive natural disasters can lead to uneven and lasting demographic changes in affected communities, even with a full recovery in physical capital.

Retropharyngeal abscess (RPA) in adults is a potentially life-threatening condition that relates in most of the cases with local trauma. Non-traumatic RPA complicated by spinal osteomyelitis and epidural abscess is a rare entity in immunocompetent adults and represents an emergency medical condition when the patient develops neurologic symptoms. This article presents a case of non-traumatic RPA complicated by spinal osteomyelitis and epidural abscess in a 77-year-old male with the free past medical history. We highlight the importance of early and meticulous daily drainage as well as sequential MRI scanning for early diagnosis, treatment and follow-up for signs of vertebral involvement. The patient had a full recovery and was subsequently discharged with per os four-month antibiotic treatment. The definitive mechanism is unclear for non-traumatic cases with "hematogenous path" being the closest description. Spontaneous RPA can develop from bacteria infection spread of adjacent structures, local inflammatory process and microthrombosis formation can impair the blood supply of vertebral and intervertebral disks.

Introduction An uncommon complication of Acute Otitis Media (AOM) is a subperiosteal temporal infection known as Luc's abscess. Zygomatic air cells (ZACs) are an uncommon anatomic variant. Case series Two otherwise healthy male patients, aged six- and thirteen years-old presented with unilateral otalgia, swelling, trismus, and fever. Imaging revealed Luc's abscess near ZACs. Antibiotics, drainage and myringotomy tubes resulted in a full recovery. Conclusion In addition to the spread of soft tissue infection through the Notch of Rivinus, the presence of ZACs may provide a pathway for suppurative effusion and development into Luc's abscess.

Bilateral synchronous proximal tibia insufficiency fractures are rarely reported. We present a case of simultaneous proximal tibia bilateral insufficiency fractures in a 51-year-old female patient with underlying psoriatic arthritis, who was on chronic steroid medication. She reported sudden onset of bilateral knee pain after intense workout one week ago. Initial clinical and X-ray evaluation did not reveal significant pathology. Four weeks later, due to persistent pain in the absence of significant radiographic findings during follow-up, the patient was referred for MRI, which revealed fractures of both proximal tibias. A "mixed" treatment protocol was applied. In particular, this protocol included combination of rest and intermittent removable knee ranger braces immobilization with weight-bearing when applied. The patient went on to make a full recovery. Chronic inflammatory disorders accompanied by suspicious clinical manifestations should be thoroughly inspected. Diagnostic and treatment protocols should be further discussed and implemented.

Intervertebral disc herniation (IVDH) is by far the most likely diagnosis for dachshunds presenting with no history of trauma and with both pain and pelvic limb paresis. A presumptive diagnosis of IVDH can usually be reached based on history and clinical examination, although mild cases can be challenging to differentiate from those with non-spinal causes of pain. This article offers a practical approach to assessing and managing the painful dachshund in first-opinion practice. It covers clinical decision-making and the principles of non-surgical treatment, emphasising the need for good monitoring and follow-up. Recovery typically takes weeks to months; full recovery is not guaranteed, and recurrence is possible, so regardless of whether spinal surgery is performed, good communication between practitioner and owner is essential.

This letter investigates the impact of self-heating on the post-cycling functionality of a scaled hafnium oxide-based ferroelectric field-effect transistor (FeFET). The full recovery of FeFET switching properties and data retention after the cycling endurance failure is reported. This is achieved by damage annealing through localized heating, which is intentionally induced by a large current flow through the drain (source)-body p-n junctions. The results highlight that the local thermal treatments could be exploited to extend the cycling endurance of FeFETs.

While the majority of individuals make full recovery within a short period following mild traumatic brain injury (mTBI), some continue to experience a more chronic course of symptoms termed persistent post-concussive symptoms (PPCS). Previous models and conceptualizations of PPCS have typically not differentiated the time at which factors present across the injury timeline spectrum or have considered a limited array of contributory factors. In the current review, PPCS are examined within the predisposing, precipitating, and perpetuating (PPP) model, which has been applied to explain other syndromes resulting in a clear framework to explain, disseminate, and further research the specified condition. Previous PPCS models are reviewed and integrated into this comprehensive model, as well. To do so, a literature review was completed which included previous PPP models applied to other conditions, other PPCS models, and more recent findings of factors related to PPCS. This new iteration and application of the PPP model more clearly, completely, and validly identifies contributing factors to PPCS. Future prevention, early identification, clearer questions for future research, and treatment of PPCS is possible with clarity provided by this model.

O Acidente Vascular Cerebral Isquêmico(AVCI) é a maior causa de incapacidades físicas e cognitivas em nosso meio. O uso da terapia trombolítica com rt-PA na fase aguda eleva significativamente a chance de uma recuperação completa. Os hospitais que tratam pacientes com AVC agudo devem ser preparados para o uso desta terapêutica. Neste artigo mostramos a seqüência, o modelo operacional e alguns resultados da implantação do protocolo rt-PA em dois hospitais de referência em Porto Alegre-RS.

Inspired by Jackass (a tv-show about self-injuring stunts), some friends topped off a drinking party with live fishes from their aquarium. After the goldfishes had gone down smoothly, a bronze catfish was ingested. Unaware of the morphology and anti-predator behaviour of this species, a healthy but intoxicated 28-year-old man got a surprise. The catfish erected and locked the spines of its pectoral fins and got lodged in the hypopharynx. After several hours, he presented himself at the emergency department with dysphonia and dysphagia. The fish had to be removed endoscopically. Intubation and admittance to the intensive care unit was necessary due to laryngeal oedema. Two weeks postoperatively, the patient made a full recovery and donated the fish to the Natural History Museum Rotterdam. The publicity generated by public exhibition of the ‘do-not-swallow-fish’ emphasised the official Jackass warning: ‘.. do not attempt any of the stunts you’re about to see’.

The development of advanced processes able to directly provide pure products by integrating chemical transformations, product separation and recovery and reuse of the solvent and the catalytic phases by straightforward and smart approaches, is a key feature to build green chemical processes. The unique properties of ILs, one of the key enabling technologies, can lead, when combined with (bio)catalysts, to amazing synergies not only improving the catalytic efficiency (i.e. improved activity and enantioselectivity, enhanced stability, etc.), but also allowing the design of smarts approaches for product separation (e.g. IL/scCO2 biphasic reactors, membrane reactors, nanodrop systems, microfluidic devices, supported ionic liquid phases, sponge-like ionic liquids, etc.), incorporating the full recovery and reuse of the catalyst and the ILs phase. This tutorial review highlights representative examples of ILs-based systems integrating reaction/separation as a tool for the development of sustainable chemical processes leading to clean and pure chemical products.

Historically, anterior cruciate ligament (ACL) suture repair mostly resulted in failure because of intra-articular hypovascularity and poor intrinsic healing capacity of ACL. ACL reconstruction was therefore deemed the gold standard with a high success rate because of more evolved surgical technique. There are, however, clinical and subclinical disadvantages of reconstruction; low rate in full recovery to sports, donor harvest morbidity, tunnel enlargement, and incomplete microscopic healing of the graft. Recent experimental and clinical studies on biological augmentation of mesenchymal stem cells, platelet-rich plasma, or the other biologic agents with scaffold suggested potential feasibility of positive effects by such bio-therapies for both ACL repair and reconstruction. Biological augmentation of ACL surgery is still in the exploratory stages and more evidence from preclinical and clinical studies is required for implementation in clinical practice.

Takotsubo cardiomyopathy is a reversible cardiomyopathy with a unique morphological feature of the left ventricle characterized by an apical ballooning appearance known for approximately known 25 years. Catecholamine drive plays an essential role in the pathogenesis and pathophysiology of Takotsubo cardiomyopathy; hence, it is also called stress cardiomyopathy. Physical stress could also have an impact and leads to a greater variety of characteristics in Takotsubo cardiomyopathy. Supportive and symptomatic medication remains the mainstay therapy with priority to improving the function of the left ventricle for several days and full recovery in 3-4 weeks. Due to its similarity with myocardial infarction, Takotsubo cardiomyopathy requires careful diagnosis and management for the best possible outcome.

Background: COVID-19 is “public enemy number one” and has placed an enormous burden on health authorities across the world. Given the wide clinical spectrum of COVID-19, understanding the factors that can predict disease severity will be essential since this will help frontline clinical staff to stratify patients with increased confidence.Purpose: To investigate the diagnostic value of the temporal radiographic changes, and the relationship to disease severity and viral clearance in COVID-19 patients.Methods: In this retrospective cohort study, we included 99 patients admitted to the Renmin Hospital of Wuhan University, with laboratory confirmed moderate or severe COVID-19. Temporal radiographic changes and viral clearance were explored using appropriate statistical methods.Results: Radiographic features from HRCT scans included ground-glass opacity, consolidation, air bronchogram, nodular opacities and pleural effusion. The HRCT scores (peak) during disease course in COVID-19 patients with severe pneumonia (median: 24.5) were higher compared to those with pneumonia (median: 10) (p=3.56×10-12), with more frequency of consolidation (p=0.025) and air bronchogram (p=7.50×10-6). The median values of days when the peak HRCT scores were reached in pneumonia or severe pneumonia patients were 12 vs. 14, respectively (p=0.048). Log-rank test and Spearman's Rank-Order correlation suggested temporal radiographic changes as a valuable predictor for viral clearance. In addition, follow up CT scans from 11 pneumonia patients showed full recovery.Conclusion: Given the values of HRCT scores for both disease severity and viral clearance, a standardised HRCT score system for COVID-19 is highly demanded.

Background Mild traumatic brain injury (mTBI) strongly associates with chronic neurodegenerative impairments such as post-traumatic stress disorder (PTSD) and mild cognitive impairment. Early detection of concussive events would significantly enhance the understanding of head injuries and provide better guidance for urgent diagnoses and the best clinical practices for achieving full recovery. New method A smart helmet was developed with a single embedded fiber Bragg grating (FBG) sensor for real-time sensing of blunt-force impact events to helmets. The transient signals provide both magnitude and directional information about the impact event, and the data can be used for training machine learning (ML) models. Results The FBG-embedded smart helmet prototype successfully achieved real-time sensing of concussive events. Transient data “fingerprints” consisting of both magnitude and direction of impact, were found to correlate with types of blunt-force impactors. Trained ML models were able to accurately predict (R2 ∼ 0.90) the magnitudes and directions of blunt-force impact events from data not used for model training. Comparison with existing methods The combination of the smart helmet data with analyses using ML models provides accurate predictions of the types of impactors that caused the events, as well as the magnitudes and the directions of the impact forces, which are unavailable using existing devices. Conclusion This work resulted in an ML-assisted, FBG-embedded smart helmet for real-time identification of concussive events using a highly accurate multi-metric strategy. The use of ML-FBG smart helmet systems can serve as an early-stage intervention strategy during and immediately following a concussive event.

Introduction: The effect of air travel on the recovery rate after idiopathic sudden sensorineural hearing loss (ISSNHL) has not been established. The advice to avoid flights is essentially based upon conjecture.Objectives: To analyze the recovery rate of patients who traveled by air shortly after they were treated for ISSNHL.Materials and methods: The hospital records of 115 newly diagnosed adult patients with unilateral ISSNHL were retrospectively collected. Included were patients who traveled by air within 90 days since the ISSNHL occurrence. The treatment protocol included oral prednisone and intratympanic dexamethasone injection when indicated. Audiograms performed upon presentation and 90 days later were compared.Results: Twelve patients were included (median age 45.5 years). The median treatment delay was 3 days. The average time from the ISSNHL to air-travel was 37 days, and the average air-travel distance was 13,362 km. The degree of HL was moderate, moderately severe, and severe (4 patients each). Seven patients (58%) underwent full recovery. No patients experienced further deterioration of their audiometric results after air-travel.Conclusions: This study does not support the avoidance of air-travel after ISSNHL.Significance: This study is the first to investigate the effect of air-travel on ISSNHL recovery rates, a clinical question that rises commonly.

Background Few patients with severe upper extremity (UE) paresis after stroke achieved full recovery, because of the lack of a definitive approach to improve severe UE paresis immediately after onset. Objective to investigate the effects of coupled EMG-triggered and cyclic neuromuscular electrical stimulation (NMES) on UE paresis during early acute phase of stroke. Methods Seventeen participants with severe UE disability met the criteria. 8 subjects received 20 minutes of NMES prior to standard care per session, while 9 age- and severity-matched subjects received two times 20 minutes of standard care. Outcome measures included UE motor section of the Fugl-Meyer Motor Assessment Scale (FMA-UE), Wolf motor function test (WMFT), and box and block test (BBT). Results The NMES group received treatment (average session: 10.87) after a median 7 days from stroke (16.5 sessions after 5 days for control). To adjust the different treatment durations, we defined "progress rate" as the gains of UE function scores divided by treatment duration. The progress rate was significantly different in FMA-UE, but not in WMFT and BBT. Conclusions The present study suggested beneficial effects of coupled NMES on UE paresis during early acute phase of stroke.

The influence of the degree of a neuromuscular block (NMB) on surgical operating conditions during laparoscopic surgery is debated controversially. The extent of abdominal distension during the time course of the NMB was assessed as a new measurement tool. In 60 patients scheduled for gynecologic laparoscopic surgery, the increase of the abdominal wall length induced by the capnoperitoneum was measured at 5 degrees of the NMB: intense NMB&mdash, post-tetanic count (PTC) = 0, deep NMB&mdash, train-of-four count (TOF) = 0 and PTC = 1&ndash, 5, medium NMB&mdash, PTC &gt, 5 and TOF = 0&ndash, 1, shallow NMB&mdash, TOF &gt, full recovery&mdash, train-of-four ratio TOFR &gt, 90%. Simultaneously, the quality of operating conditions was assessed with a standardized rating scale (SRS) reaching from 1 (extremely poor conditions) to 5 (excellent conditions). Fifty patients could be included in the analysis. The abdominal wall length increased by 10&ndash, 13 mm induced by the capnoperitoneum. SRS was higher during intense NMB (4.7 &plusmn, 0.5) vs. full recovery (4.5 &plusmn, 0.5) (mean &plusmn, SD, p = 0.025). Generally, an intense NMB did not increase abdominal wall length induced by capnoperitoneum. Additionally, its influence on the quality of surgical operating conditions seems to be of minor clinical relevance.

Nipah virus (NiV) outbreak occurred in Kozhikode district, Kerala, India in 2018 with a case fatality rate of 91% (21/23). In 2019, a single case with full recovery occurred in Ernakulam district. We described the response and control measures by the Indian Council of Medical Research and Kerala State Government for the 2019 NiV outbreak. The establishment of Point of Care assays and monoclonal antibodies administration facility for early diagnosis, response and treatment, intensified contact tracing activities, bio-risk management and hospital infection control training of healthcare workers contributed to effective control and containment of NiV outbreak in Ernakulam.

Delayed eruption of a canine tooth may represent a possible impaction. If this is the case, a slight elevation in the palatal or vestibular mucosa is often observed. Cases of transmigration, where the unerupted tooth crosses the midline, are less frequent. This article reports on the piezosurgery-assisted surgical treatment of a transmigrated canine in the mentonian region. Treatment for this condition varies depending on the clinical characteristics, symptoms, and location of the dental element. The surgical treatment established for this case was satisfactory, and full recovery of the patient was achieved without complications such as an intense postoperative inflammatory response.

BACKGROUND Spontaneous spinal extradural hematoma (SSEH) is a rare but disabling disorder. Most of the previous assumptions regarding the factors that contribute to poor neurological recovery from SSEH are based on small case samples or conditions with similar clinical presentations but different physiopathologies. Our goal was to find the most relevant prognostic factors for neurological recovery in patients suffering SSEH treated with surgical evacuation. METHODS From a retrospective database of 29 surgical patients with SSEH, several clinical and radiological variables were recorded. These variables were compared between patients with good and poor neurological recovery, considering good as an improvement by at least one point in the ASIA Scale. RESULTS Among the patients included, morbidity and mortality rate was 6.9% and 3.4%, respectively, with a mean follow-up of 7.1 months. Neurological full recovery was experienced by 33% of the patients included, and 86% of individuals had an improvement in their neurological condition at last follow-up. Lesser intramedullary lesions were significantly associated with greater chances of improvement in ASIA Scale at discharge and at follow-up. Surgical decompression within the first 24 hours of onset of symptoms were correlated with better neurological outcomes at follow-up. CONCLUSIONS MRI is a powerful tool to predict the neurological outcome in SSEH patients, and it should be considered as an another resource to better know the patients with greater chances of having neurological recovery, especially in cases where the neurological examination is not reliable at the initial exam.

Introduction Diseases of the salivary glands are rare in children and adolescents, with the exception of viral-induced infections. Objective To determine the clinical course of the disease, the diagnostic procedures, the treatment and the outcome of all children and adolescents affected with salivary gland diseases at our clinic over a period of 15 years. Methods A retrospective chart review including a long-term follow-up was conducted among 146 children and adolescents treated for salivary gland disorders from 2002 to 2016. Results Diagnosing acute sialadenitis was easily managed by all doctors regardless of their specialty. The diagnosis of sialolithiasis was rapidly made only by otorhinolaryngologists, whereas diagnosing juvenile recurrent parotitis imposed difficulties to doctors of all specialties – resulting in a significant delay between the first occurrence of symptoms and the correct diagnosis. The severity-adjusted treatment yielded improvements in all cases, and a full recovery of 75% of the cases of sialolithiasis, 73% of the cases of juvenile recurrent parotitis, and 100% of the cases of acute sialadenitis. Conclusions Due to their low prevalence and the lack of pathognomonic symptoms, salivary gland diseases in children and adolescents are often misdiagnosed, resulting in an unnecessarily long period of suffering despite a favorable outcome following the correct treatment.

Inflammatory heart disease (IHD) is a group of diseases that includes pericarditis, myocarditis, and endocarditis. Although males appear to be more commonly affected than females, IHD can be seen in any age group. While the disease can be self-limiting leading to full recovery, affected individuals can develop chronic disease, suggesting that identification of primary triggers is critical for successful therapies. Adding to this complexity, however, is the fact that IHD can be triggered by a variety of infectious and non-infectious causes that can also occur as secondary events to primary insults. In this review, we discuss the immunological insights into the development of IHD as well as a mechanistic understanding of the disease process in animal models.

We report the case of a 16-year-old girl diagnosed with myocarditis, although initial echocardiographic imaging was consistent with hypertrophic cardiomyopathy (HCM). The diagnosis of myocarditis was made with the findings of troponin elevation, presence of influenza A, and a more characteristic electrocardiogram. She eventually made a full recovery. Clinicians must be vigilant for such rare presentations of myocarditis masquerading as HCM.

A simple and inexpensive strategy is reported to facilitate the detection of an organophosphorus pesticide by acetylcholinesterase (AChE). Pullulan is able to preserve AChE at room temperature, but the activity of conserved AChE varies significantly depending on the time, stir and volume of solution to dissolve it. The reason is that AChE entrapped in pullulan tablet remains in an inactive state to avoid denaturalization and deactivation. There is a reactivation process to gradually recover the enzyme activity during dissolution of the tablet. Stirring would interrupt this procedure and lead to a loss of enzyme activity. Dissolution of the tablet for 5 min with a volume of 15 μL could facilitate full recovery of AChE activity. The feasibility of activated AChE for organophosphorus pesticide detection was evaluated using malaoxon. These results contribute to the understanding of preservation mechanism by pullulan and the development of easy-to-use enzyme assays.

Background Free fibular flap is one of the most useful methods in the hard tissue reconstruction of the maxilla-mandible. Free fibular flap presents some advantages in which the reconstruction of both soft and hard tissues can be done at the same time. It also provides a safe and successful bone graft for the reconstruction, along with a low rate of complications. Despite these advantages and the rarity of a postoperative complication, particularly in oral and maxillofacial surgery procedures, a prolonged operation might exhibit some complications related with rhabdomyolysis. We experienced the rare event of rhabdomyolysis after oral cancer surgery. Case presentation In this article, we report the case of a patient who developed rhabdomyolysis after undergoing free fibular flap surgery. Conclusions Despite the advantages of the free fibular flap operation, clinicians must be aware of the risk of complications because there are multiple factors that could result in rhabdomyolysis, such as duration of operation, position of the subject, and pre-existing conditions of diabetes and hypertension. Once the diagnosis of rhabdomyolysis is confirmed, a prompt treatment plan should be made and applied as soon as possible. This will increase the chance of a full recovery for the patient who is exhibiting symptoms of rhabdomyolysis.

Over the past decade, the nephrology and critical care communities have adopted a consensus approach to diagnosing acute kidney injury (AKI) and, as a result, we have seen transformative changes in our understanding of pediatric AKI epidemiology. The data regarding outcomes among neonates and children who develop AKI have become far more robust and AKI has been clearly linked with an increased need for mechanical ventilation, longer inpatient stays, and higher mortality. Though AKI was historically thought to be self-limited, we now know that renal recovery is far from universal, particularly when AKI is severe; the absence of recovery from AKI also carries longitudinal prognostic implications. AKI survivors, especially those without full recovery, are at risk for chronic renal sequelae including proteinuria, hypertension, and chronic kidney disease. This review comprehensively describes AKI-related outcomes across the entire pediatric age spectrum, using the most rigorous studies to identify the independent effects of AKI events.

We aimed to assess the rate and type of postoperative motor deficits that might be encountered following elbow flexion reanimation using ulnar- and/or median-based side-to-end nerve transfers in patients with brachial plexus injuries. All patients who underwent elbow flexion reanimation between November 2015 and October 2017 at our facility by nerve transfer based on partial harvests of the median and/or ulnar nerves were included. Postoperative clinical assessment was conducted the day after surgery to identify motor deficits in the territory of the harvested nerves. If a clinically noticeable deficit was present, the type and extent of the deficit were noted, and postoperative clinical evaluations were conducted monthly to determine its progression. After reviewing the charts of 27 consecutive patients, 4 patients were found to have a postoperative motor deficit (15%). In all four cases, the deficit was limited to the anterior interosseous nerve (AIN) territory in patients who underwent a double transfer (i.e., ulnar-to-biceps and median-to-brachialis). With clinical impairments of the flexor pollicis longus and/or the flexor digitorum profundus of the index and third fingers initially ranging from grade-0 to grade-3 strength, full recovery to preoperative strength levels occurred in all cases after a mean of 7 months’ follow-up. Transient motor deficits may be observed in the AIN territory following elbow flexion reanimation when a median-to-brachialis nerve transfer is associated with the original Oberlin procedure.

A number of constraints to the full recovery of a peripheral nerve injury are being fought with a battery of novel promising tools. Anat Rec, 301:1606-1613, 2018. © 2018 Wiley Periodicals, Inc.

Current state of zoobenthos in the areas of scallop Chlamys islandica beds in the southern Barents Sea and eastern White Sea (Voronka) is described. The scallop stock is ex­ploited there with the landing by specialized vessels, without separation of catch, so bycatch of other species is considerable. As the result, significant changes occurred in structure of benthic communities during the times of scallop fishery. To assess the fishery effect, species composition of benthos, its dominant species and trophic structure is considered separately for 4 regions with different degree of exploitation. Dynamics of zoobenthos abundance is traced over the last 25 years. Changes in trophic structure of the benthic community at Cape Svyatoy Nos (southern Barents Sea) are analyzed in details. Although up to ¼ of its total biomass is presented by carnivorous species and the biomass of C. islandica has decreased, the portion of sestonophages has increased in this community. Recently a recovery of zoob­enthos is observed in its southern part, supposedly because of the animals redistribution from adjacent areas unaffected by fishery. On the contrary, extremely low biomass of zoobenthos, in particular scallop, is observed in the northern part of the community. Biomass of benthos in the Voronka area is high, but it is formed mainly by mussels. There is concluded that more than a decade is required for full recovery of the scallop stock and accompanying zoobenthos communities to the native state.

The unique properties of two-dimensional (2D) materials make them promising candidates for chemical and biological sensing applications. However, most 2D material sensors suffer from extremely long recovery time due to the slow molecular desorption at room temperature. Here, we report an ultrasensitive p-type molybdenum ditelluride (MoTe2) gas sensor for NO2 detection with greatly enhanced sensitivity and recovery rate under ultraviolet (UV) illumination. Specifically, the sensitivity of the sensor to NO2 is dramatically enhanced by 1 order of magnitude under 254 nm UV illumination as compared to that in the dark condition, leading to a remarkable low detection limit of 252 ppt. More importantly, the p-type MoTe2 sensor can achieve full recovery after each sensing cycle well within 160 s at room temperature. Finally, the p-type MoTe2 sensor also exhibits excellent sensing performance to NO2 in ambient air and negligible response to H2O, indicating its great potential in practical applications, such as bre...

Introduction: Traffic accidents are of the most common causes for emergency ward admissions with variable outcomes ranging from full recovery to death. In order to have an accurate policy setting, the information regarding the accidents should be unraveled. The present study was carried out aiming to describe traffic accidents causing trauma in one of Iran’s major municipalities. Methods: In this cross-sectional study, 757 patients admitted to the emergency wards with the background of traffic accidents were included in the study. All patients had signed informed consent before participating in the study. Data regarding these patients were extracted from the hospital information system (HIS) and then analyzed. Results: The mean age of the patients was 33.09 ± 17.19. Most of the patients (70.7%) were men. Almost two third of the patients were injured inside the cities. Accidents happening on the inter-city roads were significantly related to the car collisions. Emergency medical services (EMS) were the most common route of admission and referral. The head trauma had the highest incidence rate among all traumas based on location. Accidents on the inter-city roads were related to the injury to the neck, thorax, and upper limbs. Conclusion: Based on various factors effecting trauma caused in traffic accidents, the clinical picture was variable. It is important to have an understanding of the situation regarding traffic accidents in order to further enhance the quality of care for these patients

An odontogenic cause of a lung abscess is often overlooked. A 61-year-old man presented at an emergency department with a productive cough and dyspnoea. He was admitted to the pulmonary ward with a suspected odontogenic lung abscess. A thorax CT scan confirmed the diagnosis 'lung abscess', following which an oral-maxillofacial surgeon confirmed that the lung abscess probably had an odontogenic cause. The patient made a full recovery following a 6-week course of antibiotics, and his teeth were remediated by means of full extraction and the fabrication of immediate dentures. Poor oral hygiene can be a cause of a lung abscess. A patient with a lung abscess can be treated successfully with antibiotics. If, however, the odontogenic cause is not recognised the abscess can recur.Een odontogene oorzaak van een longabces wordt regelmatig over het hoofd gezien. Een 61-jarige man kwam met een productieve hoest en kortademigheid op een Spoedeisende Hulp. Vanwege een mogelijk odontogeen longabces werd hij opgenomen op de afdeling Longziekten. Een CT-scan van de thorax bevestigde de diagnose ‘longabces’, waarna een mka-chirurg een odonto­gene oorzaak van het abces aannemelijk maakte. De patiënt herstelde volledig met een antibioticumkuur van 6 weken en zijn gebit werd gesaneerd door totaalextractie en vervaardiging van immediaatprothese. Slechte mond­hygiëne kan een oorzaak zijn van een longabces. Een patiënt met een long­abces kan succesvol worden behandeld met een antibioticumkuur. Als een odonto­gene oorzaak over het hoofd wordt gezien kan het abces echter recidiveren.

Objectives This study aimed to assess if playing wind instruments leads to a measurable increase in middle ear pressure during note generation and to provide evidence to clinicians to advise musicians undergoing middle ear surgery. Study design An observational cohort study of 40 volunteers in 7 different wind instrument categories underwent tympanometry at rest and during note production. Setting Community. Patients Recreational musicians aged over 18 years recruited from the student body attending Birmingham University, UK. Intervention None. Main outcome measures Tympanometry is used as a noninvasive measure of middle ear pressure. The pressure at which peak compliance occurred was taken as an indirect measure of middle ear pressure. The data produced at rest and during note production was statistically analysed with paired t testing and significance set at a p value less than 0.01. Results Overall a statistically significant increase in middle ear pressure change of 0.63 mm Hg (p = 0.0001) during note production was identified. Musicians playing the oboe and trumpet demonstrate the largest increase in middle ear pressure of 1.46 mm Hg (p = 0.0053) and 0.78 mm Hg (p = 0.0005) respectively. Conclusion The data provided by this study gives evidence for the first time that playing wind instruments does increase middle ear pressure. Although the clinical significance of this is yet to be determined the authors would advise that musicians who undergo otological procedures should refrain from playing their instruments until full recovery has been achieved as advised by their clinician following direct microscopic review.

Constipation is a common problem in childhood that need frequent visit to pediatrician. The objective of this review is to provide the general pediatrician an overview of constipation in children discussing the etiology, patient evaluation and management. This review provides an approach to a child with constipation based on the best available evidence from electronic literature searches. Most common etiology of childhood constipation is functional and it needs no laboratory tests. Laboratory investigations are to be done if there are any alarming signs. Management is to do disimpaction if fecal impaction present, then long term maintenance therapy along with behavioral therapy ensure full recovery.Bangladesh J Child Health 2017; VOL 41 (3) :170-180

Three-dimensional (3-D) printing is a method of manufacturing in which materials like plastic or metal are deposited onto one another in layers to produce a 3-D object. Because of the complex anatomy of craniomaxillofacial structures, full recovery of craniomaxillofacial tissues from trauma, surgeries, or congenital malformations is extremely challenging. 3-D printing of scaffolds, tissue analogs, and organs has been proposed as an exciting alternative to address some of these key challenges in craniomaxillofacial surgery. There are four broad types of 3-D printing surgical applications that can be used in craniomaxillofacial surgery: contour models (positive-space models to allow preapplication of hardware before surgery), guides (negative-space models of actual patient data to guide cutting and drilling), splints (negative-space models of virtual postoperative positions to guide final alignment), and implants (negative-space 3-D printed implantable materials or 3-D printed molds into which nonprintable materials are poured). 3-D printing technology is being successfully used for surgeries for head and neck malignancies, mandibular reconstruction, orthognathic surgeries, for mandibulectomies after osteoradionecrosis, orbital floor fracture surgeries, nasal reconstruction, and cranioplasties. The excitement behind 3-D printing continues to increase and hopefully will drive improvements in the technology and its surgical applications, especially in craniomaxillofacial region. This present review sets out to explore use of 3-D printing technologies in craniomaxillofacial surgery.

Purpose This study aimed to investigate the clinical and socioenvironmental characteristics of sudden cardiorespiratory arrest after venipuncture in children. Methods We conducted a retrospective email-based survey of all members of the Korean Pediatric Society. The questionnaire included items on patient demographics, socioenvironmental circumstances of the venipuncture, type of cardiorespiratory arrest, symptoms and signs, treatment, prognosis, and presumed cause of the arrest. Results Fourteen patients were identified. Of these, 13 were young children (

Tubo-ovarian abscess (TOA) coexists in 15% of cases with pelvic inflammatory disease. Medical treatment is the first line of approach in women with TOA, however, 25% of cases fail to respond to antibiotics, therefore, these cases need to undergo surgical intervention. We aimed to determine factors leading to failure of medical treatment in women diagnosed with TOA. According to our results among 144 women, 27 cases required surgical intervention for full recovery. None of the demographic, sonographic or laboratory findings, including procalcitonin level, had significant predictive value for the failure of medical treatment in women with TOA. Impact statement What is already known on this subject? Tubo-ovarian abscess (TOA) coexists in 15% of cases with pelvic inflammatory disease. Medical treatment is the first line approach in women with TOA, however, 25% of cases fail to respond to antibiotics, therefore, these cases need to undergo surgical intervention. Several risk factors have been evaluated in order to predict the failure of medical treatment. What do the results of this study add? None of the variables, including age, parity, mass diameter, serum CRP, procalcitonin levels and sedimentation rate had significant value for predicting TOA cases that required surgical intervention for full recovery. What are the implications of these findings for clinical practice and/or further research? In clinical practice, identification of risk factors leading to the failure of medical treatment helps clinicians to inform patients and help surgeons predict those who need surgical intervention.

Tonsillar herniation and coning is a rare and often late presentation of meningoencephalitis, and is associated with poor neurological outcome. We report the case of a 16-year-old female who presented unresponsive with radiological evidence of tonsillar herniation secondary to meningoencephalitis. She underwent an emergency foramen magnum decompression and C1 laminectomy with full recovery and no residual neurological deficit.

The citrus canning industry generates large quantities of processing water rich in phytochemical compounds during the sequential acidic and alkaline removal of the citrus segments membrane. However, this processing water was discharged as an effluent causing high chemical oxygen demand (COD). In the present research, a pilot scale process was designed to simultaneously recover pectin and a low molecular weight (Mw) fraction. The pectin was stable in yield and showed a relatively high content of galacturonic acid (∼60%) throughout the production season. The low Mw fraction was rich in oligosaccharides (∼11 mg/mL) and flavonoids (∼3 mg/mL). Oral intake of the low Mw fraction could remarkably inhibit the growing of human non-small cell lung cancer PC-9 cells in nude mice. After treatment, the COD of the water was reduced by more than 95%, allowing more economical disposal of the wastewater. It is estimated that a citrus canning factory could retrieve about 110 tons of pectin in a production season, in addition to large amounts of low Mw fraction. Such an approach to recover valuable compounds from processing water is both beneficial for the environment and economy.

Background Spinal schwannomas are the most common intradural extramedullary tumors. However, a string of beadlike schwannomas is rare. In some cases, the beadlike tumors might present a multiple segmental growing pattern, often located in the lumbar spinal canal and on 1 nerve fiber. Despite its benign nature, the resection of this string of beadlike tumors could be a challenge to neurosurgeons, especially when the tumors extend to a long distance. Case Description A 50-year-old female was admitted to our hospital, and her diagnosis was beadlike schwannomas. We performed 2 small hemilaminectomies and pulled all the tumors out gently. The patient made a full recovery quickly after resection. Conclusions In this case, we first reported a new surgical approach for the removal of a string of beadlike cauda equina schwannomas. We hypothesize that this procedure would be a potential addition to the present surgical methods under some circumstances.

Objective Pituitary apoplexy can cause severe neuro-ophthalmologic or endocrinologic sequelae, requiring timely treatment. The present study was performed to evaluate postoperative neurologic outcomes and to identify their risk factors in patients who underwent transsphenoidal surgery for pituitary apoplexy. Methods Forty-one consecutive patients with pituitary apoplexy who underwent transsphenoidal surgery were reviewed retrospectively. The initial rates of visual acuity (VA) decrease, visual field (VF) defect, and ocular palsy were 34.1%, 46.3%, and 68.3%, respectively. The median maximal diameter and tumoral volume was 2.6 cm (range, 2.0–4.6 cm) and 5.3 cm3 (range, 2.4–38.8 cm3), respectively. Seventeen patients (41.5%) underwent surgery within 7 days. The median follow-up duration was 45 months (range, 12–196 months). Results At the last follow-up, 62.9% (22/35) of patients had made a full recovery from preoperative neurologic deficits, with partial recovery observed in the remaining patients. The rates of improvement and full recovery from VA decrease were 92.9% and 57.1%, respectively; those from VF defect were 94.7% and 36.8%, respectively; and those from ocular palsy were 100.0% and 96.4%, respectively. On multivariate analysis, initial visual impairment score (≥20) was the only significant risk factor for postoperative neurologic sequelae (P Conclusions Ocular palsy was fully recovered in 96.4% patients with pituitary apoplexy after transsphenoidal surgery. Initial visual impairment status was found to be more strongly associated with postoperative neurologic recovery than surgical timing.

A 44-year-old female, with a background of cerebral palsy, epilepsy and learning disabilities, presented with multiple seizures and a persistently reduced consciousness level secondary to valproate-induced hyperammonaemic encephalopathy (plasma levels >50 μg/dl). Withdrawal of valproate and subsequent infusion of L-carnitine led to full recovery. Nonhepatic hyperammonaemia has been shown to be effectively treated by intravenous L-carnitine therapy by a series of case reports. To date, no randomised controlled trials have demonstrated this. Hyperammonaemic encephalopathy is possibly a more common presentation than expected that is currently underdiagnosed and exacerbated by valproate.