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972 results on '"FERMEGLIA, MAURIZIO"'

201. Design, synthesis and anti flaviviridae activity of N6-, -O- and 5 O-substituted adenine nucleoside analogs

Author

ANGUSTI A, MANFREDINI S, DURINI E, CILIBERTI N, VERTUANI S, SOLAROLI N, LODDO R, SECCI B, VISIOLI A, SANNA T, COLLU G, PEZZULLO M, LA COLLA P., PRICL, SABRINA, FERRONE, MARCO, FERMEGLIA, MAURIZIO, Angusti, A, Manfredini, S, Durini, E, Ciliberti, N, Vertuani, S, Solaroli, N, Pricl, Sabrina, Ferrone, Marco, Fermeglia, Maurizio, Loddo, R, Secci, B, Visioli, A, Sanna, T, Collu, G, Pezzullo, M, and LA COLLA, P.

Published
2008

219. Nanocompositi: da micro a mesoscala

Author

SCOCCHI, GIULIO, POSOCCO, PAOLA, FERMEGLIA, MAURIZIO, FERRONE, MARCO, PRICL, SABRINA, Handgraaf JW, Fraajie JGEM, Scocchi, Giulio, Posocco, Paola, Fermeglia, Maurizio, Ferrone, Marco, Pricl, Sabrina, Handgraaf, Jw, and Fraajie, Jgem

Subjects
polymer nanocomposites, computer-assisted molecular simulation, Multiscale molecular modeling, polymer nanocomposite
Abstract

La prospettiva generale di questo lavoro consiste nell’integrazione completa di tutte le scale di simulazione ora disponibili, all’interno di una procedura gerarchica finalizzata a fornire un protocollo di simulazione efficiente e solido, idoneo alla progettazionendi PCN di interesse industriale e la previsione della loro performance finale.

Published
2007

225. Design, synthesis and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against a single-stranded positive sense RNA genome viruses

Author

CARTA A, LORIGA M, PAGLIETTI G, SANNA T, IBBA C, LA COLLA P, LODDO R., FERRONE, MARCO, FERMEGLIA, MAURIZIO, PRICL, SABRINA, Carta, A, Loriga, M, Paglietti, G, Ferrone, Marco, Fermeglia, Maurizio, Pricl, Sabrina, Sanna, T, Ibba, C, LA COLLA, P, and Loddo, R.

Subjects
Antiviral Agents
Published
2007

230. Chasing the evaders. Design, synthesis, activity and molecular modelling of a new small molecule with activity against drug-resistant HIV-1-mutants

Author

Pricl, Sabrina, Ferrone, Marco, Posocco, Paola, Fermeglia, Maurizio, Sanna, G., Collu, G., La Colla, P., Loddo, R., Sias, A., Piras, S., Carta, A., Pricl, Sabrina, Ferrone, Marco, Posocco, Paola, Fermeglia, Maurizio, Sanna, G., Collu, G., La Colla, P., Loddo, R., Sias, A., Piras, S., and Carta, A.

Subjects
reverse transcriptase, hiv, Computer simulation
Published
2006

231. Steady state dimulation of energy production from biomass by molten carbonate fuel cells

Author

DONOLO G, DE SIMON, GIULIO, FERMEGLIA, MAURIZIO, Donolo, G, DE SIMON, Giulio, and Fermeglia, Maurizio

Subjects
biomass, Fuel cell, simulazione di processo, bioma
Abstract

Descrizione: This paper presents an integrated approach to the steady state simulation of biomass gasification, fuel cells and power generation processes. Attention is devoted to molten carbonate fuel cells (MCFC) due to the relative low cost, simpler construction and flexibility in the use of fuel. A steady state model simulating a global MCFC power plant based on real plants data is described and the simulations are selected according to real operating conditions. The software developed allows to study ‘`ın silico’ the effect of variations of the process conditions as well as modification of the input fuel, thus providing a useful tool for supporting technical decisions and feasibility study on the use of fuel cells in developing countries. The paper reports results of computer simulation focusing on macroscopic quantities of interest such as stack efficiency, global process electrical efficiency, cogenerative efficiency. The computer simulation is applied to a feasibility

Published
2006

233. Functional analysis and molecular modelling show a preserved wild type activity of p53 C238Y

Author

Ferrone, Marco, Perrone, F, Tamborini, E, Paneni, Maria Silvia, Fermeglia, Maurizio, Suardi, S, Pastore, E, Delia, D, Pierotti, M. A., Pricl, Sabrina, Pilotti, S., Ferrone, Marco, Perrone, F, Tamborini, E, Paneni, Maria Silvia, Fermeglia, Maurizio, Suardi, S, Pastore, E, Delia, D, PIEROTTI M., A, Pricl, Sabrina, and Pilotti, S.

Subjects
molecular modeling
Published
2006

234. Many-Scale Simulation of ABS/PC Blends for the Automotive Industry

Author

FERMEGLIA, MAURIZIO, FERRONE, MARCO, PANENI, Maria Silvia, POSOCCO, PAOLA, Cosoli P., Venica R., Sinesi S., Martinelli L., Vincenzini P., Fermeglia, Maurizio, Ferrone, Marco, Cosoli, P., Paneni, Maria Silvia, Venica, R., Sinesi, S., Posocco, Paola, and Martinelli, L.

Subjects
polymer blends, multiscale molecular modeling, polymer blend
Published
2006

236. Of life and Death: Chronic Myeloid Leukemia and the Bcr-Abl/Imatinib Paradigm

Author

FERRONE, MARCO, FERMEGLIA, MAURIZIO, PANENI, Maria Silvia, PRICL, SABRINA, Pierotti M. A., Pilotti S., Tamborini E., Joseph T. Golab, Clare McCabe, Ferrone, Marco, Fermeglia, Maurizio, Paneni, Maria Silvia, Pierotti, M. A., Pilotti, S., Tamborini, E., and Pricl, Sabrina

Subjects
chronic myeloid leukemia
Published
2006

237. Angels and demons of the guardian of the genome. A coupled modeling-biochemical study of p53 mutants in ovarian cancer

Author

PRICL, SABRINA, FERRONE, MARCO, PANENI, Maria Silvia, FERMEGLIA, MAURIZIO, Cosoli P., Perrone F., Da Riva L., Tamborini E., Suardi S., Pierotti M. P., Pilotti S., AACR, Pricl, Sabrina, Ferrone, Marco, Paneni, Maria Silvia, Cosoli, P., Fermeglia, Maurizio, Perrone, F., Da Riva, L., Tamborini, E., Suardi, S., Pierotti, M. P., and Pilotti, S.

Subjects
p53
Published
2006

239. Delivered to Perfection at Nanoscale. A Coupled Multiscale Simulation/Experimental Investigation of Protein Release from Nanochannel Delivery Systems

Author

FERMEGLIA, MAURIZIO, FERRONE, MARCO, PANENI, Maria Silvia, PRICL, SABRINA, Cosoli P., Cosentino C., Amato F., Cheng M. M. C., Walczak R., Ferrari M., Joseph T. Golab, Clare McCabe, Fermeglia, Maurizio, Ferrone, Marco, Cosoli, P., Paneni, Maria Silvia, Cosentino, C., Amato, F., Cheng, M. M. C., Walczak, R., Pricl, Sabrina, and Ferrari, M.

Subjects
Nanochannel Delivery Systems, Protein Release
Published
2006

240. Functional analyses and Molecular modeling of two c-Kit mutations responsible for Imatinib secondary resistance in GIST patients

Author

Tamborini, E, Pricl, Sabrina, Negri, T, Lagonigro, M. S., Miselli, F, Greco, A, Gronchi, A, Casali, P, Ferrone, Marco, Fermeglia, Maurizio, Pierotti, M. A., Pilotti, S., Tamborini, E, Pricl, Sabrina, Negri, T, LAGONIGRO M., S, Miselli, F, Greco, A, Gronchi, A, Casali, P, Ferrone, Marco, Fermeglia, Maurizio, PIEROTTI M., A, and Pilotti, S.

Subjects
drug resistance, imatinib, cancer target therapy, molecular simulations, molecular simulation
Abstract

Imatinib-acquired resistance related to the presence of secondary point mutations has become a frequent event in gastrointestinal stromal tumors. Here, transient transfection experiments with plasmids carrying two different KIT-acquired point mutations were performed along with immunoprecipitation of total protein extracts, derived from imatinib-treated and untreated cells. The molecular mechanics/Poisson Boltzmann surface area computational techniques were applied to study the interactions of the wild-type and mutated receptors with imatinib at the molecular level. Biochemical analyses showed KIT phosphorylation in cells transfected with vectors carrying the specific mutant genes. Imatinib treatment demonstrated that T670I was insensitive to the drug at all the applied concentrations, whereas V654A was inhibited by 6 lM of imatinib. The modeling of the mutated receptors revealed that both substitutions affect imatinib-binding site, but to a different extent: T670I substantially modifies the binding pocket, whereas V654A induces only relatively confined structural changes. We demonstrated that T670I and V654A cause indeed imatinib-acquired resistance and that the former is more resistant to imatinib than the latter. The application of molecular simulations allowed us to quantify the interactions between the mutated receptors and imatinib, and to propose a molecular rationale for this type of drug resistance.

Published
2006

241. A new twist for an old song. The DABO story revisited

Author

Pricl, Sabrina, Ferrone, Marco, Posocco, Paola, Pavan, G. M., Fermeglia, Maurizio, La Colla, P., Loddo, R., Pricl, Sabrina, Ferrone, Marco, Posocco, Paola, Pavan, G. M., Fermeglia, Maurizio, La Colla, P., and Loddo, R.

Subjects
hiv, reverse transcriptase, computer simulation
Published
2006

245. siRNA Delivery: Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016)

Author

Chen, Chao, primary, Posocco, Paola, additional, Liu, Xiaoxuan, additional, Cheng, Qiang, additional, Laurini, Erik, additional, Zhou, Jiehua, additional, Liu, Cheng, additional, Wang, Yang, additional, Tang, Jingjie, additional, Col, Valentina Dal, additional, Yu, Tianzhu, additional, Giorgio, Suzanne, additional, Fermeglia, Maurizio, additional, Qu, Fanqi, additional, Liang, Zicai, additional, Rossi, John J., additional, Liu, Minghua, additional, Rocchi, Palma, additional, Pricl, Sabrina, additional, and Peng, Ling, additional

Published
2016
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246. Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing

Author

Chen, Chao, primary, Posocco, Paola, additional, Liu, Xiaoxuan, additional, Cheng, Qiang, additional, Laurini, Erik, additional, Zhou, Jiehua, additional, Liu, Cheng, additional, Wang, Yang, additional, Tang, Jingjie, additional, Col, Valentina Dal, additional, Yu, Tianzhu, additional, Giorgio, Suzanne, additional, Fermeglia, Maurizio, additional, Qu, Fanqi, additional, Liang, Zicai, additional, Rossi, John J., additional, Liu, Minghua, additional, Rocchi, Palma, additional, Pricl, Sabrina, additional, and Peng, Ling, additional

Published
2016
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248. Upgrading block co-polymers from post industrial rejects: a multiscale simulation approach

Author

Fermeglia, Maurizio, Cosoli, P., Ferrone, Marco, Paneni, Maria Silvia, Pricl, Sabrina, Martinelli, L., Sinesi, S., Candus, M., J. Kenny, Fermeglia, Maurizio, Cosoli, P., Ferrone, Marco, Paneni, Maria Silvia, Pricl, Sabrina, Martinelli, L., Sinesi, S., and Candus, M.

Subjects
Nanotechnology, computer multiscale modeling, Nanocomposites, Nanotechnology, computer multiscale modeling, Nanocomposites
Published
2005

249. Take a walk on the nano side: structural and energetical analysis of ATP-binding pocket mutations of the cardiac beta-myosin heavy chain implicated in familial hypertrophic cardiomyopathy

Author

Cosoli, P., Ferrone, Marco, Paneni, Maria Silvia, Fermeglia, Maurizio, Pricl, Sabrina, Mason M., Fantechi S., Tomellini R., Cosoli, P., Ferrone, Marco, Paneni, Maria Silvia, Fermeglia, Maurizio, and Pricl, Sabrina

Subjects
Myosin, computer simulation, computer simulations, Myosins, mutations
Published
2005

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