18,071 results on '"FACCHINI A."'
Search Results
202. Palliative Arterial Embolization for Metastases of the Sternum
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Papalexis, Nicolas, Peta, Giuliano, Vara, Giulio, Spinnato, Paolo, Errani, Costantino, Martella, Claudia, Miceli, Marco, and Facchini, Giancarlo
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- 2023
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203. CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
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Domenico Mallardo, Mario Fordellone, Andrew White, Margaret Ottaviano, Francesca Sparano, Michael Bailey, Arianna Bianca Facchini, Sufey Ong, Piera Maiolino, Corrado Caracò, Sarah Church, Ernesta Cavalcanti, Sarah Warren, Alfredo Budillon, Alessandra Cesano, Ester Simeone, Paolo Chiodini, and Paolo Antonio Ascierto
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Melanoma ,NLR ,CD39 ,HDLA ,TGFβ ,Biomarker ,Medicine - Abstract
Abstract Background Identifying response markers is highly needed to guide the treatment strategy in patients with metastatic melanoma. Methods A retrospective study was carried out in patients with unresectable/metastatic melanoma (stage IIIb–IV), treated with anti-PD-1 in the first line setting, to better explore the role and the timing of neutrophil/lymphocyte ratio (NLR) as potential biomarker of response. The relationship of NLR with inflammation-immune mediators and the underlying negative effect of raising NLR during immunotherapy, have been investigated with transcriptomic gene analysis. Results The results confirmed previous findings that a high baseline NLR is associated with a poorer prognosis and with higher serum level of lactate dehydrogenase (LDH), regardless of the presence of brain metastases. The transcriptomic analysis showed that high baseline NLR is associated with a characteristic gene signature CCNA1, LDHA and IL18R1, which correlates with inflammation and tumorigenesis. Conversely, low baseline NLR is associated with the signature CD3, SH2D1A, ZAP70 and CD45RA, linked to the immune-activation. The genes positively associated with NLR (CD39 (ENTPD1), PTEN, MYD88, MMP9 and LDH) are involved in processes of immunosuppression, inflammation and tumor-promoting activity. Increased expression of CD39 correlated with TGFβ2, a marker of the N2 neutrophils with immunosuppressive activity. Conclusions These results suggest that increasing NLR is associated with an increased neutrophil population, with polarization to the N2 phenotype, and this process may be the basis for the negatively prognostic role of NLR.
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- 2023
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204. Feasibility of cabazitaxel in octogenarian prostate cancer patients
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Paolo Tralongo, Sebastiano Bordonaro, Giuseppe Di Lorenzo, Ugo De Giorgi, Nicolò Borsellino, Gaetano Facchini, Sabrina Rossetti, Giuseppe Fornarini, Vito Longo, Antonino Carmelo Tralongo, Francesca Caspani, Massimiliano Spada, Nicola Calvani, and Paolo Carlini
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract. Background. To evaluate the effectiveness and safety of cabazitaxel in castration-resistant prostate cancer patients aged ≥80 years, we performed a retrospective study on a sample of patients from 11 Italian cancer centers. Materials and methods. Fifty-seven patients aged ≥80 years were treated with cabazitaxel after previous failure with docetaxel; 39 completed a comprehensive geriatric assessment questionnaire (34 fit and 5 vulnerable) and 8 patients (14%) had an Eastern Cooperative Oncology Group performance status (PS) ≥2, while most had a PS of 0–1 (86%). Cabazitaxel was administered at a dose of 25 mg/m2 in 30 (52%) patients and 20 mg/m2 or adapted schedules in 27 (48%) patients. These schedules were adopted mainly in patients ≥85 years (75%), with a PS ≥2 (87.5%), and those classified as vulnerable (100%). Results. The duration of treatment was 4.8 months and was comparable in all subgroups; disease control rate was reported in 36 patients (63%); prostate-specific antigen response was recorded in 18 patients (31.5%). Median overall survival was 13.1 months regardless of age (
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- 2023
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205. Towards the Automation of Data Networks
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Santiago Cristóbal Pérez, Higinio Alberto Facchini, Bruno Alejandro Roberti-Ferri, María Eugenia Stefanoni, and Matilde Inés Césari
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artificial intelligence ,automation platforms ,automation tools ,network automation ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
A wide variety of enterprises, corporations, communications service providers (CSPs), and experts have highlighted the difficulty of managing modern networks. These networks exhibit high-impact technological innovations, such as cloud computing, mobility, new traffic profiles, network functions virtualization (NFV), the Internet of things (IoT), Big Data, among others. Network automation is a methodology in which physical and virtual network devices are automatically configured, provisioned, managed, and tested using software. Large enterprises such as Cisco, Juniper, Red Hat, and VMWare offer proprietary solutions for network automation. Additionally, the number of tools assisting in network automation has recently increased. Taken together, these developments have changed the way administrators build and manage networks. In this regard, most large communications operators are now working and moving toward truly autonomous networks that will eventually require an intensive use of Artificial Intelligence (AI). Advances in the area show that three specific segments —CSPs, Cloud Providers, and Enterprises— are all at different stages of automation maturity. Over time, network automation is expected to reach smaller organizations as well. This paper presents a specialized, detailed and current technical study on the state of the art in network automation, highlighting the trends observed in information technology (IT) environments, enterprises and communications operators —which are closely involved in this technology—, and concludes with a discussion on automation tools.
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- 2023
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206. The New Ice Age of Musculoskeletal Intervention: Role of Percutaneous Cryoablation in Bone and Soft Tissue Tumors
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Nicolas Papalexis, Leonor Garbin Savarese, Giuliano Peta, Costantino Errani, Gianmarco Tuzzato, Paolo Spinnato, Federico Ponti, Marco Miceli, and Giancarlo Facchini
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interventional radiology ,metastatic neoplasms ,orthopedic surgery ,palliative medicine ,cryoablation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In the rapidly evolving field of interventional oncology, minimally invasive methods, including CT-guided cryoablation, play an increasingly important role in tumor treatment, notably in bone and soft tissue cancers. Cryoablation works using compressed gas-filled probes to freeze tumor cells to temperatures below −20 °C, exploiting the Joule–Thompson effect. This cooling causes cell destruction by forming intracellular ice crystals and disrupting blood flow through endothelial cell damage, leading to local ischemia and devascularization. Coupling this with CT technology enables precise tumor targeting, preserving healthy surrounding tissues and decreasing postoperative complications. This review reports the most important literature on CT-guided cryoablation’s application in musculoskeletal oncology, including sarcoma, bone metastases, and bone and soft tissue benign primary tumors, reporting on the success rate, recurrence rate, complications, and technical aspects to maximize success for cryoablation in the musculoskeletal system.
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- 2023
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207. Older Adults' Risk Perception during the COVID-19 Pandemic in Lombardy Region of Italy: A Cross-sectional Survey
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Guastafierro, Erika, primary, Toppo, Claudia, additional, Magnani, Francesca G., additional, Romano, Rosa, additional, Facchini, Carla, additional, Campioni, Rino, additional, Brambilla, Ersilia, additional, and Leonardi, Matilde, additional
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- 2023
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208. Toleration and cohabitation
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Facchini, Cristiana, primary
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- 2023
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209. A IMPORTÂNCIA DE CONHECER A DIVERSIDADE EM SALA DE AULA
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Lourenço, Cláudia Mara, primary, Fernandes, Eduarda Dadalt, additional, Soldá, Elisabete Fátima, additional, Casanova, Fernanda, additional, Oliveira, Katilene da Silva de, additional, Facchini, Isadora, additional, Matos, Marizete de, additional, Dadalt, Paula Roberta, additional, and Zanatta, Sílvia Mara, additional
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- 2023
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210. Cigarette smoking and mammographic breast density in post-menopausal women from the EPIC Florence cohort
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Benedetta Bendinelli, Saverio Caini, Melania Assedi, Ilaria Ermini, Elisa Pastore, Luigi Facchini, Maria Antonietta Gilio, Giacomo Duroni, Miriam Fontana, Andrea Querci, Daniela Ambrogetti, Calogero Saieva, and Giovanna Masala
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cigarette smoking ,mammographic breast density ,post-menopausal women ,breast cancer ,lifestyle ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionCigarette smoking has been recognized as a risk factor for breast cancer (BC) also if the biological mechanism remains poorly understood. High mammographic breast density (MBD) is associated with BC risk and many BC risk factors, such as genetic, anthropometric, reproductive and lifestyle factors and age, are also able to modulate MBD. The aim of the present study was to prospectively explore, in post-menopausal women, the association between smoking habits and MBD, assessed using an automated software, considering duration and intensity of smoking.MethodsThe analysis was carried out in 3,774 women enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) Florence cohort in 1993-98, participating in the 2004-06 follow up (FU) and with at least one full-field digital mammography (FFDM) performed after FU. For each woman, detailed information on smoking habits, anthropometry, lifestyle and reproductive history was collected at enrollment and at FU. Smoking information at baseline and at FU was integrated. The fully automated Volpara™ software was used to obtain total breast volume (cm3), absolute breast dense volume (DV, cm3) and volumetric percent density (VPD, %) from the first available FFDM (average 5.3 years from FU). Multivariable linear regression models were applied to evaluate the associations between smoking habits and VPD or DV.ResultsAn inverse association between smoking exposure and VPD emerged (Diff% -7.96%, p
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- 2024
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211. Factors associated with hospitalizations and deaths of pregnant women from Paraná due to COVID-19: a cross-sectional study
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Larissa Silva Bergantini, Sueli Mutsumi Tsukuda Ichisato, Maria Aparecida Salci, Marcela Maria Birolim, Márcia Lorena Alves dos Santos, Carla Franciele Höring, Roberta Rossa, and Luiz Augusto Facchini
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COVID-19 ,Cross-sectional studies ,Pregnant women ,Hospitalization ,Intensive care units ,Maternal mortality ,Public aspects of medicine ,RA1-1270 - Abstract
ABSTRACT Objective: To analyze the factors associated with hospitalization in the ward and intensive care unit (ICU), and with death from COVID-19 in pregnant women with confirmed cases. Methods: Observational, cross-sectional study, carried out with data from pregnant women with a confirmed case of COVID-19 from the Influenza Epidemiological Surveillance Information System and the Paraná’s state COVID-19 notification system. The association between the independent and dependent variables (hospitalization in the ward and ICU, and death) was investigated using the Poisson regression model with robust variance. Results: 4,719 pregnant women comprised the study population. 9.6 and 5.1% were hospitalized in wards and ICU, respectively. 1.9% died. There was an association between advanced maternal age and hospitalization in wards (PR=1.36; 95%CI 1.10–1.62) and ICU (PR=2.25; 95%CI 1.78–2.71), and death (PR=3.22; 95%CI 2.30–4.15). An association was found between the third trimester and hospitalization in wards (PR=5.06; 95%CI 2.82–7.30) and ICU (PR=6.03; 95%CI 3.67–8.39) and death (PR=13.56; 95%CI 2.90–24.23). The second trimester was associated with ICU admission (PR=2.67; 95%CI 1.36–3.99). Pregnant women with cardiovascular disease had a higher frequency of hospitalization in wards (PR=2.24; 95%CI 1.43–3.05) and ICU (PR=2.66; 95%CI 1.46–3.87). Obesity was associated with ICU admission (PR=3.79; 95%CI 2.71–4.86) and death (PR=5.62; 95%CI 2.41–8.83). Conclusions: Advanced maternal age, the end of the gestational period and comorbidities were associated with severe COVID-19.
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- 2024
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212. Gene Signatures predict immune-related skin adverse events in melanoma patients
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D. Mallardo, M. Fordellone, M. Bailey, A. White, E. Simeone, L. Festino, V. Vanella, C. Trojaniello, M.G. Vitale, M. Ottaviano, F. Sparano, B.A. Facchini, E. Cavalcanti, S. Church, C. Caracò, A. Cesano, S. Warren, P. Chiodini, and P.A. Ascierto
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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213. P005: Atidarsagene autotemcel (hematopoietic stem cell–gene therapy) preserves cognitive and motor development in metachromatic leukodystrophy with up to 12 years follow-up
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Francesca Fumagalli, Valeria Calbi, Fabiola De Mattia, Alberto Zambon, Vera Gallo, Salvatore Recupero, Elena Sophia Fratini, Alessia Ippolito, Francesca Ciotti, Maddalena Fraschini, Marina Sarzana, Stefano Scarparo, Eugenio Montini, Sara Locatelli, Marcella Facchini, Alessandra Clerici, Francesco Morena, Sabata Martino, Muska Yarzi, Sean Moro, Andrew Shenker, Jean Brooks, Alan Richardson, Leslie Meltzer, Laura Campbell, and Alessandro Aiuti
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Genetics ,QH426-470 ,Medicine - Published
- 2024
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214. Influence of invasive aspergillosis during acute leukaemia treatment on survival after allogeneic stem cell transplantation: a prospective study of the EBMT Infectious Diseases Working PartyResearch in context
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Olaf Penack, Gloria Tridello, Urpu Salmenniemi, Rodrigo Martino, Nina Khanna, Katia Perruccio, Franca Fagioli, Monika Richert-Przygonska, Hélène Labussière-Wallet, Johan Maertens, Charlotte Jubert, Mahmoud Aljurf, Herbert Pichler, Gergely Kriván, Desiree Kunadt, Marina Popova, Melissa Gabriel, Elisabetta Calore, Igor Wolfgang Blau, Fabio Benedetti, Maija Itäla-Remes, Elizabeth de Kort, Domenico Russo, Maura Faraci, Anne-Lise Ménard, Peter von dem Borne, Xavier Poiré, Akif Yesilipek, Jolanta Gozdzik, Zeynep Arzu Yeğin, Lucrecia Yañez, Luca Facchini, Gwendolyn Van Gorkom, Lorenz Thurner, Ulker Kocak, Antònia Sampol, Tsila Zuckerman, Marc Bierings, Stephan Mielke, Fabio Ciceri, Lotus Wendel, Nina Knelange, Malgorzata Mikulska, Dina Averbuch, Jan Styczynski, Rafael de la Camara, and Simone Cesaro
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Invasive ,Aspergillosis ,Stem cell transplantation ,Mortality ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Infections are the main reason for mortality during acute leukaemia treatment and invasive aspergillosis (IA) is a major concern. Allogeneic stem cell transplantation (alloSCT) is a standard therapy and often is the only live-saving procedure in leukaemia patients. The profound immunodeficiency occurring after alloSCT led to high IA-associated mortality in the past. Therefore, patients with IA were historically considered transplant-ineligible. Recently, there has been improvement of anti-fungal management including novel anti-fungal agents. As a result, more leukaemia patients with IA are undergoing alloSCT. Outcome has not been prospectively assessed. Methods: We performed a prospective study in acute leukaemia patients undergoing alloSCT to analyse the impact of a prior history of probable or proven IA (pre-SCT IA). The primary endpoint was 1-year non-relapse mortality (NRM). Relapse free survival and overall survival were analysed as secondary endpoints. Findings: 1439 patients were included between 2016 and 2021. The incidence of probable or proven pre-SCT IA was 6.0% (n = 87). The cumulative incidence of 1-year NRM was 17.3% (95% CI 10.2–26.0) and 11.2% (9.6–13.0) for patients with and without pre-SCT IA. In multivariate analyses the hazard ratio (HR) for 1-year NRM was 2.1 (1.2–3.6; p = 0.009) for patients with pre-SCT IA. One-year relapse-free survival was inferior in patients with pre-SCT IA (59.4% [48.3–68.9] vs. 70.4 [67.9–72.8]; multivariate HR 1.5 [1.1–2.1]; p = 0.02). Consequently, 1-year overall survival was lower in patients with pre-SCT IA: (68.8% [57.8–77.4] vs. 79.0% [76.7–81.1]; multivariate HR 1.7 [1.1–2.5]; p = 0.01). Interpretation: Pre-SCT IA remains to be significantly associated with impaired alloSCT outcome. On the other hand, more than two thirds of patients with pre-SCT IA were alive at one year after alloSCT. IA is not anymore an absolute contraindication for alloSCT because the majority of patients with IA who undergo alloSCT benefit from this procedure. Funding: There was no external funding source for this study.
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- 2024
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215. Hospitalização de idosos por COVID-19 no Paraná: uma análise de fatores associados
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Vanessa Neckel Derin, Giovanna Brichi Pesce, Carla Franciele Höring, Débora Regina de Oliveira Moura, João Ricardo Nickenig Vissoci, Luiz Augusto Facchini, Maria Aparecida Salci, and Lígia Carreira
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Idoso ,COVID-19 ,Infecções por coronavírus ,Hospitalização ,Pandemias ,Prevalência ,Nursing ,RT1-120 - Abstract
Resumo Objetivo Analisar a prevalência e os fatores associados à hospitalização de idosos com COVID-19 no estado do Paraná, PR, Brasil. Métodos Estudo transversal vinculado à coorte “Acompanhamento Longitudinal de adultos e idosos que receberam alta da internação hospitalar por COVID-19”, realizado por meio de informações contidas nas fichas de notificação compulsória do Sistema de Informação de Agravos de Notificação. As análises foram realizadas através de frequências relativas e absolutas, com aplicação do teste de qui-quadrado adotado no modelo de regressão logística. A população do estudo englobou pessoas residentes no Estado do Paraná com idade de 60 anos ou mais, hospitalizadas por COVID-19 no período de março de 2020 a setembro de 2021. Resultados Foi identificada maior prevalência de hospitalização entre idosos com escolaridade igual ou maior a oito anos. Indivíduos não vacinados contra COVID-19 apresentaram maior chance de internação. O sexo masculino apresentou mais chance de admissão em Unidade de Terapia Intensiva em comparação com o sexo feminino. Doenças cardiovasculares, pneumopatia e obesidade aumentaram a prevalência da forma grave da doença. Conclusão Fatores tais como escolaridade e não adesão à vacinação contra COVID-19 podem aumentar o risco de hospitalização pela doença. Pessoas idosas do sexo masculino apresentam maior chance de hospitalização na UTI se comparadas às do sexo feminino; além disso, a não utilização de antivirais pode contribuir para o agravamento do estado de saúde.
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- 2024
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216. Editorial: Food loss and waste management, from the grave to the cradle: a new resource for the world
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Bartolomeo Silvestri, Luigi Ranieri, and Francesco Facchini
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food loss and waste (FLW) ,food supply chain ,sustainable food loss and waste management ,food waste hierarchy ,consumer behavior ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Published
- 2024
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217. New methods for ALMA angular-scale based observation scheduling, quality assessment, and beam shaping
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Petry, Dirk, Trigo, María Díaz, Kneissl, Rüdiger, Toledo, Ignacio, and Facchini, Stefano
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Up to now, the completion of an ALMA interferometric observation is determined based on the achievement of a given shape and size of the synthesized beam and the noise RMS in the representative spectral range. This approach with respect to the angular resolution investigates mainly the longest baselines of the interferometer and says little about the sensitivity at larger angular scales. We are exploring the ideas of angular-scale-based scheduling and quality assessment, and of angular-scale-based visibility weighting as a step towards optimising both observation efficiency and image fidelity. This approach carries the imaging quality assurance into the visibility space where interferometers record the data, and therefore simplifies many aspects of the procedure. Similarly, during scheduling such detailed assessment of the expected imaging properties helps optimising the scheduling process. The methodology is applicable to all radio interferometers with more than ca. 10 antennas., Comment: Proc SPIE Astronomical Telescopes and Instrumentation, 2020, 12 pages, 7 figures
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- 2020
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218. High resolution observations of molecular emission lines toward the CI Tau proto-planetary disc: planet-carved gaps or shadowing?
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Rosotti, Giovanni P., Ilee, John D., Facchini, Stefano, Tazzari, Marco, Booth, Richard, Clarke, Cathie, and Kama, Mihkel
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Recent observations have revealed that most proto-planetary discs show a pattern of bright rings and dark gaps. However, most of the high-resolution observations have focused only on the continuum emission. In this Paper we present high-resolution ALMA band 7 (0.89mm) observations of the disc around the star CI Tau in the $^{12}$CO & $^{13}$CO $J=3$-2 and CS $J=7$-6 emission lines. Our recent work demonstrated that the disc around CI Tau contains three gaps and rings in continuum emission, and we look for their counterparts in the gas emission. While we find no counterpart of the third gap and ring in $^{13}$CO, the disc has a gap in emission at the location of the second continuum ring (rather than gap). We demonstrate that this is mostly an artefact of the continuum subtraction, although a residual gap still remains after accounting for this effect. Through radiative transfer modelling we propose this is due to the inner disc shadowing the outer parts of the disc and making them colder. This raises a note of caution in mapping high-resolution gas emission lines observations to the gas surface density - while possible, this needs to be done carefully. In contrast to $^{13}$CO, CS emission shows instead a ring morphology, most likely due to chemical effects. Finally, we note that $^{12}$CO is heavily absorbed by the foreground preventing any morphological study using this line., Comment: 17 pages, 17 figures; accepted for publication in MNRAS
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- 2020
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219. A highly non-Keplerian protoplanetary disc: Spiral structure in the gas disc of CQ Tau
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Wölfer, Lisa, Facchini, Stefano, Kurtovic, Nicolas T., Teague, Richard, van Dishoeck, Ewine F., Benisty, Myriam, Ercolano, Barbara, Lodato, Giuseppe, Miotello, Anna, Rosotti, Giovanni, Testi, Leonardo, and Gabellini, Maria Giulia Ubeira
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Astrophysics - Earth and Planetary Astrophysics - Abstract
In the past years, high angular resolution observations have revealed that circumstellar discs appear in a variety of shapes with diverse substructures being ubiquitous. This has given rise to the question of whether these substructures are triggered by planet-disc interactions. Besides direct imaging, one of the most promising methods to distinguish between different disc shaping mechanisms is to study the kinematics of the gas disc. In particular, the deviations of the rotation profile from Keplerian velocity can be used to probe perturbations in the gas pressure profile that may be caused by embedded planets. In this paper we aim to analyze the gas brightness temperature and kinematics of the transitional disc around the CQ Tau star in order to resolve and characterize substructure in the gas, caused by possible perturbers. For our analysis we use spatially resolved ALMA observations of 12CO, 13CO and C18O (J=2-1). We further extract robust line centroids for each channel map and fit a number of Keplerian disc models to the velocity field. The gas kinematics of the CQ Tau disc present non-Keplerian features, showing bent and twisted iso-velocity curves in 12CO and 13CO. Significant spiral structures are detected between 10-180 au in both the brightness temperature and the rotation velocity of 12CO after subtraction of an azimuthally symmetric model, which may be tracing planet-disc interactions with an embedded planet or low-mass companion. We identify three spirals, two in the brightness temperature and one in the velocity residuals, spanning a large azimuth and radial extent. The brightness temperature spirals are morphologically connected to spirals observed in NIR scattered light in the same disc, indicating a common origin. Together with the observed large dust and gas cavity, the spirals support the hypothesis of a massive embedded companion in the CQ Tau disc., Comment: 16 pages, 15 figures; accepted for publication in A&A
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- 2020
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220. Remote determination of the shape of Jupiter's vortices from laboratory experiments
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Lemasquerier, Daphné, Facchini, Giulio, Favier, Benjamin, and Bars, Michael Le
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Fluid Dynamics - Abstract
Jupiter's dynamics shapes its cloud patterns but remains largely unknown below this natural observational barrier. Unraveling the underlying three-dimensional flows is thus a primary goal for NASA's ongoing Juno mission that was launched in 2011. Here, we address the dynamics of large Jovian vortices using laboratory experiments complemented by theoretical and numerical analyses. We determine the generic force balance responsible for their three-dimensional pancake-like shape. From this, we define scaling laws for their horizontal and vertical aspect ratios as a function of the ambient rotation, stratification and zonal wind velocity. For the Great Red Spot in particular, our predicted horizontal dimensions agree well with measurements at the cloud level since the Voyager mission in 1979. We additionally predict the Great Red Spot's thickness, inaccessible to direct observation: it has surprisingly remained constant despite the observed horizontal shrinking. Our results now await comparison with upcoming Juno observations.
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- 2020
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221. Multi-wavelength continuum sizes of protoplanetary discs: scaling relations and implications for grain growth and radial drift
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Tazzari, Marco, Clarke, Cathie J., Testi, Leonardo, Williams, Jonathan P., Facchini, Stefano, Manara, Carlo F., Natta, Antonella, and Rosotti, Giovanni
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We analyse spatially resolved ALMA observations at 0.9, 1.3, and 3.1 mm for the 26 brightest protoplanetary discs in the Lupus star-forming region. We characterise the discs multi-wavelength brightness profiles by fitting the interferometric visibilities in a homogeneous way, obtaining effective disc sizes at the three wavelengths, spectral index profiles and optical depth estimates. We report three fundamental discoveries: first, the millimeter continuum size - luminosity relation already observed at 0.9 mm is also present at 1.3 mm with an identical slope, and at 3.1 mm with a steeper slope, confirming that emission at longer wavelengths becomes increasingly optically thin. Second, when observed at 3.1 mm the discs appear to be only 9% smaller than when observed at 0.9 mm, in tension with models of dust evolution which predict a starker difference. Third, by forward modelling the sample of measurements with a simple parametric disc model, we find that the presence of large grains ($a_\mathrm{max}>1 $mm) throughout the discs is the most favoured explanation for all discs as it reproduces simultaneously their spectral indices, optical depth, luminosity, and radial extent in the 0.9-1.3 mm wavelength range. We also find that the observations can be alternatively interpreted with the discs being dominated by optically thick, unresolved, substructures made of mm-sized grains with a high scattering albedo., Comment: MNRAS Accepted. 20 pages, 12 figures, 5 tables. Detailed fit results in Appendix E (27 pages, 78 figures), available as supplementary material. Machine-readable version of Table 1, Table 2, and Table 3 available at https://zenodo.org/record/4756381
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- 2020
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222. The first ALMA survey of protoplanetary discs at 3 mm: demographics of grain growth in the Lupus region
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Tazzari, Marco, Testi, Leonardo, Natta, Antonella, Williams, Jonathan P., Ansdell, Megan, Carpenter, Jonathan M., Facchini, Stefano, Guidi, Greta, Hogherheijde, Michiel, Manara, Carlo F., Miotello, Anna, and van der Marel, Nienke
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the first ALMA survey of protoplanetary discs at 3 mm, targeting 36 young stellar objects in the Lupus star-forming region with deep observations (sensitivity 20-50 microJy/beam) at ~0.35" resolution (~50 au). Building on previous ALMA surveys at 0.89 and 1.3 mm that observed the complete sample of Class II discs in Lupus at a comparable resolution, we aim to assess the level of grain growth in the relatively young Lupus region. We measure 3 mm integrated fluxes, from which we derive disc-averaged 1-3 mm spectral indices. We find that the mean spectral index of the observed Lupus discs is $\alpha_\mathrm{1-3 mm}=2.23\pm0.06$, in all cases $\alpha_\mathrm{1-3 mm}<3.0$, with a tendency for larger spectral indices in the brightest discs and in transition discs. Furthermore, we find that the distribution of spectral indices in Lupus discs is statistically indistinguishable from that of the Taurus and Ophiuchus star-forming regions. Assuming the emission is optically thin, the low values $\alpha_\mathrm{1-3 mm}\leq 2.5$ measured for most discs can be interpreted with the presence of grains larger than 1 mm. The observations of the faint discs in the sample can be explained without invoking the presence of large grains, namely through a mixture of optically thin and optically thick emission from small grains. However, the bright (and typically large) discs do inescapably require the presence of millimeter-sized grains in order to have realistic masses. Based on a disc mass argument, our results challenge previous claims that the presence of optically thick sub-structures may be a universal explanation for the empirical millimeter size-luminosity correlation observed at 0.89 mm., Comment: MNRAS Accepted; 12 pages, 5 figures, 2 tables. Machine-readable tables available at https://zenodo.org/record/4756282
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- 2020
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223. An ALMA survey of $\lambda$ Orionis disks: from supernovae to planet formation
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Ansdell, Megan, Haworth, Thomas J., Williams, Jonathan P., Facchini, Stefano, Winter, Andrew, Manara, Carlo F., Hacar, Alvaro, Chiang, Eugene, van Terwisga, Sierk, van der Marel, Nienke, and van Dishoeck, Ewine F.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Protoplanetary disk surveys by the Atacama Large Millimeter/sub-millimeter Array (ALMA) are now probing a range of environmental conditions, from low-mass star-forming regions like Lupus to massive OB clusters like $\sigma$ Orionis. Here we conduct an ALMA survey of protoplanetary disks in $\lambda$ Orionis, a ~5 Myr old OB cluster in Orion, with dust mass sensitivities comparable to the surveys of nearby regions (~0.4 $M_\oplus$). We assess how massive OB stars impact planet formation, in particular from the supernova that may have occurred ~1 Myr ago in the core of $\lambda$ Orionis; studying these effects is important as most planetary systems, including our Solar System, are likely born in cluster environments. We find that the effects of massive stars, in the form of pre-supernova feedback and/or a supernova itself, do not appear to significantly reduce the available planet-forming material otherwise expected at the evolved age of $\lambda$ Orionis. We also compare a lingering massive "outlier" disk in $\lambda$ Orionis to similar systems in other evolved regions, hypothesizing that these outliers host companions in their inner disks that suppress disk dispersal to extend the lifetimes of their outer primordial disks. We conclude with numerous avenues for future work, highlighting how $\lambda$ Orionis still has much to teach us about perhaps one of the most common types of planet-forming environments in the Galaxy., Comment: 21 pages, 8 figures, 3 tables. Accepted to AAS Journals
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- 2020
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224. Visualizing the Kinematics of Planet Formation
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Disk Dynamics Collaboration, Armitage, Philip J., Bae, Jaehan, Benisty, Myriam, Bergin, Edwin A., Casassus, Simon, Czekala, Ian, Facchini, Stefano, Fung, Jeffrey, Hall, Cassandra, Ilee, John D., Keppler, Miriam, Kuznetsova, Aleksandra, Gal, Romane Le, Loomis, Ryan A., Lyra, Wladimir, Manger, Natascha, Perez, Sebastian, Pinte, Christophe, Price, Daniel J., Rosotti, Giovanni, Szulagyi, Judit, Schwarz, Kamber, Simon, Jacob B., Teague, Richard, and Zhang, Ke
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Astrophysics - Earth and Planetary Astrophysics - Abstract
A stunning range of substructures in the dust of protoplanetary disks is routinely observed across a range of wavelengths. These gaps, rings and spirals are highly indicative of a population of unseen planets, hinting at the possibility of current observational facilities being able to capture planet-formation in action. Over the last decade, our understanding of the influence of a young planet on the dynamical structure of its parental disk has progressed significantly, revealing a host of potentially observable features which would betray the presence of a deeply embedded planet. In concert, recent observations have shown that subtle perturbations in the kinematic structure of protoplanetary disks are found in multiple sources, potentially the characteristic disturbances associated with embedded planets. In this work, we review the theoretical background of planet-disk interactions, focusing on the kinematical features, and the current methodologies used to observe these interactions in spatially and spectrally resolved observations. We discuss the potential pit falls of such kinematical detections of planets, providing best-practices for imaging and analysing interferometric data, along with a set of criteria to use as a benchmark for any claimed detection of embedded planets. We finish with a discussion on the current state of simulations in regard to planet-disk interactions, highlighting areas of particular interest and future directions which will provide the most significant impact in our search for embedded planets. This work is the culmination of the 'Visualizing the Kinematics of Planet Formation' workshop, held in October 2019 at the Center for Computational Astrophysics at the Flatiron Institute in New York City., Comment: To be submitted to PASA. Comments welcome
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- 2020
225. Tractable Inference in Credal Sentential Decision Diagrams
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Mattei, Lilith, Antonucci, Alessandro, Mauá, Denis Deratani, Facchini, Alessandro, and Llerena, Julissa Villanueva
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Computer Science - Artificial Intelligence - Abstract
Probabilistic sentential decision diagrams are logic circuits where the inputs of disjunctive gates are annotated by probability values. They allow for a compact representation of joint probability mass functions defined over sets of Boolean variables, that are also consistent with the logical constraints defined by the circuit. The probabilities in such a model are usually learned from a set of observations. This leads to overconfident and prior-dependent inferences when data are scarce, unreliable or conflicting. In this work, we develop the credal sentential decision diagrams, a generalisation of their probabilistic counterpart that allows for replacing the local probabilities with (so-called credal) sets of mass functions. These models induce a joint credal set over the set of Boolean variables, that sharply assigns probability zero to states inconsistent with the logical constraints. Three inference algorithms are derived for these models, these allow to compute: (i) the lower and upper probabilities of an observation for an arbitrary number of variables; (ii) the lower and upper conditional probabilities for the state of a single variable given an observation; (iii) whether or not all the probabilistic sentential decision diagrams compatible with the credal specification have the same most probable explanation of a given set of variables given an observation of the other variables. These inferences are tractable, as all the three algorithms, based on bottom-up traversal with local linear programming tasks on the disjunctive gates, can be solved in polynomial time with respect to the circuit size. For a first empirical validation, we consider a simple application based on noisy seven-segment display images. The credal models are observed to properly distinguish between easy and hard-to-detect instances and outperform other generative models not able to cope with logical constraints., Comment: To appear in the International Journal of Approximate Reasoning (IJAR Volume 125)
- Published
- 2020
226. Disk Evolution Study Through Imaging of Nearby Young Stars (DESTINYS): A close low mass companion to ET Cha
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Ginski, C., Ménard, F., Rab, Ch., Mamajek, E. E., van Holstein, R. G., Benisty, M., Manara, C. F., Torres, R. Asensio, Bohn, A., Birnstiel, T., Delorme, P., Facchini, S., Garufi, A., Gratton, R., Hogerheijde, M., Huang, J., Kenworthy, M., Langlois, M., Pinilla, P., Pinte, C., Ribas, Á., Rosotti, G., Schmidt, T. O. B., Ancker, M. van den, Wahhaj, Z., Waters, L. B. F. M., Williams, J., and Zurlo, A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
To understand the formation of planetary systems, one needs to understand the initial conditions of planet formation, i.e. the young gas-rich planet forming disks. Spatially resolved high-contrast observations are of particular interest, since substructures in disks, linked to planet formation, can be detected and close companions or even planets in formation embedded in the disk can be revealed. In this study we present the first result of the DESTINYS survey (Disk Evolution Study Through Imaging of Nearby Young Stars). DESTINYS is an ESO/SPHERE large program that aims at studying disk evolution in scattered light, mainly focusing on a sample of low-mass stars (<1$M_\odot$) in nearby (~200 pc) star-forming regions. In this particular study we present the observations of the ET Cha (RECX 15) system, a nearby 'old' classical T Tauri star (5-8 Myr, ~100 pc), which is still strongly accreting. We use SPHERE/IRDIS in H-band polarimetric imaging mode to obtain high contrast images of the ET Cha system to search for scattered light from the circumstellar disk as well as thermal emission from close companions. We additionally employ VLT/NACO total intensity archival data taken in 2003. We report here the discovery of a low-mass (sub)stellar companion with SPHERE/IRDIS to ET Cha. We are estimating the mass of this new companion based on photometry. Depending on the system age it is a 5 Myr, 50 $M_{Jup}$ brown dwarf or an 8 Myr, 0.10 $M_\odot$ M-type pre-main-sequence star. We explore possible orbital solutions and discuss the recent dynamic history of the system. Independent of the precise companion mass we find that the presence of the companion likely explains the small size of the disk around ET Cha. The small separation of the binary pair indicates that the disk around the primary component is likely clearing from the outside in, explaining the high accretion rate of the system., Comment: 14 pages, 9 figures, accepted for publication in A&A on 09-07-2020
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- 2020
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227. Annular substructures in the transition disks around LkCa 15 and J1610
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Facchini, S., Benisty, M., Bae, J., Loomis, R., Perez, L., Ansdell, M., Mayama, S., Pinilla, P., Teague, R., Isella, A., and Mann, A.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present high resolution millimeter continuum ALMA observations of the disks around the T Tauri stars LkCa 15 and J1610. These disks host dust-depleted inner regions, possibly carved by massive planets, and are of prime interest to study the imprints of planet-disk interactions. While at moderate angular resolution they appear as a broad ring surrounding a cavity, the continuum emission resolves into multiple rings at a resolution of ~60$\times$40 mas (~7.5 au for LkCa 15, ~6 au for J1610) and ~$7\,\mu$Jy beam$^{-1}$ rms at 1.3 mm. In addition to a broad extended component, LkCa 15 and J1610 host 3 and 2 narrow rings, respectively, with two bright rings in LkCa 15 being radially resolved. The rings look marginally optically thick, with peak optical depths of ~0.5 (neglecting scattering), in agreement with high angular resolution observations of full disks. We perform hydrodynamical simulations with an embedded, sub-Jovian-mass planet and show that the observed multi-ringed substructure can be qualitatively explained as the outcome of the planet-disk interaction. We note however that the choice of the disk cooling timescale alone can significantly impact the resulting gas and dust distributions around the planet, leading to different numbers of rings and gaps and different spacings between them. We propose that the massive outer disk regions of transition disks are favorable places for planetesimals and possibly second generation planet formation of objects with a lower mass than the planets carving the inner cavity (typically few $M_{\rm Jup}$), and that the annular substructures observed in LkCa 15 and J1610 may be indicative of planetary core formation within dust-rich pressure traps. Current observations are compatible with other mechanisms being at the origin of the observed substructures, in particular with narrow rings generated at the edge of the CO and N$_2$ snowlines., Comment: 17 pages, accepted for publication in Astronomy & Astrophysics
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- 2020
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228. Constraining the radial drift of millimeter-sized grains in the protoplanetary disks in Lupus
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Trapman, L., Ansdell, M., Hogerheijde, M. R., Facchini, S., Manara, C. F., Miotello, A., Williams, J. P., and Bruderer, S.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Recent ALMA surveys of protoplanetary disks have shown that for most disks the extent of the gas emission is greater than the extent of the thermal emission of the millimeter-sized dust. Both line optical depth and the combined effect of radially dependent grain growth and radial drift may contribute to this observed effect. For a sample of 10 disks from the Lupus survey we investigate how well dust-based models without radial dust evolution reproduce the observed 12CO outer radius, and determine whether radial dust evolution is required to match the observed gas-dust size difference. We used the thermochemical code DALI to obtain 12CO synthetic emission maps and measure gas and dust outer radii (Rco, Rmm) using the same methods as applied to the observations, which were compared to observations on a source-by-source basis. For 5 disks we find that the observed gas-dust size difference is larger than the gas-dust size difference due to optical depth, indicating that we need both dust evolution and optical depth effects to explain the observed gas-dust size difference. For the other 5 disks the observed gas-dust size difference can be explained using only line optical depth effects. We also identify 6 disks not included in our initial sample but part of a survey of the same star-forming region that show significant 12CO emission beyond 4 x Rmm. These disks, for which no Rco is available, likely have gas-dust size differences greater than 4 and are difficult to explain without substantial dust evolution. Our results suggest that radial drift and grain growth are common features among both bright and fain disks. The effects of radial drift and grain growth can be observed in disks where the dust and gas radii are significantly different, while more detailed models and deeper observations are needed to see this effect in disks with smaller differences., Comment: 17 pages, 11 figures, accepted in A&A
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- 2020
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229. ALMA chemical survey of disk-outflow sources in Taurus (ALMA-DOT): I. CO, CS, CN, and H2CO around DG Tau B
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Garufi, Antonio, Podio, Linda, Codella, Claudio, Rygl, Kazi, Bacciotti, Francesca, Facchini, Stefano, Fedele, Davide, Miotello, Anna, Teague, Richard, and Testi, Leonardo
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The chemical composition of planets is inherited by the distribution of the various molecular species in the protoplanetary disk at thetime of their formation. As of today, only a handful of disks has been imaged in multiple spectral lines with high spatial resolution. As part of a small campaign devoted to the chemical characterization of disk-outflow sources in Taurus, we report on new ALMA Band 6 observations with 20 au resolution toward the embedded young star DG Tau B. Images of the continuum emission reveals a dust disk with rings and, putatively, a leading spiral arm. The disk, as well as the prominent outflow cavities, are detected in CO, H2CO, CS, and CN while they remain undetected in SO2, HDO, and CH3OH. From the absorption of the back-side outflow, we inferred that the disk emission is optically thick in the inner 50 au. This morphology explains why no line emission is detected from this inner region and poses some limitations toward the calculation of the dust mass and the characterization of the inner gaseous disk. The H2CO and CS emission from the inner 200 au is mostly from the disk and their morphology is very similar. The CN emission significantly differs from the other two molecules as it is observed only beyond 150 au. This ring-like morphology is consistent with previous observations and the predictions of thermochemical disk models. Finally, we constrained the disk-integrated column density of all molecules. In particular, we found that the CH3OH/H2CO ratio must be smaller than 2, making the methanol non-detection still consistent with the only such a ratio available from the literature (1.27 in TW Hya)., Comment: 13 pages, 6 figures, accepted by A&A
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- 2020
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230. Unusual spectral categories
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Paniagua, María José Arroyo, Facchini, Alberto, Gran, Marino, and Janelidze, George
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Mathematics - Category Theory ,Mathematics - Rings and Algebras ,18A20, 18A40, 18B30, 18G05 - Abstract
The paper is devoted to a kind of `very non-abelian' spectral categories. Under strong conditions on a category $\mathcal{X}$, we prove, among other things, that, for a given faithful localization $\mathcal{C}\to\mathcal{X}$, we have canonical equivalences $\mathrm{Spec}(\mathcal{C})\sim\mathcal{X}\sim(\mathrm{Category\,\,of\,\,injective\,\,objects\,\,in}\,\, \mathcal{C})$, and that $\mathcal{C}$ has natural injective envelopes., Comment: 10 pages
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- 2020
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231. A growth model driven by curvature reproduces geometric features of arboreal termite nests
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Facchini, Giulio, Lazarescu, Alexandre, Perna, Andrea, and Douady, Stéphan
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Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
We present a simple three-dimensional model to describe the autonomous expansion of a substrate which grows driven by the local mean curvature of its surface. The model aims to reproduce the nest construction process in arboreal Nasutitermes termites, whose cooperation may similarly be mediated by the shape of the structure they are walking on, for example focusing the building activity of termites where local mean curvature is high. We adopt a phase-field model where the nest is described by one continuous scalar field and its growth is governed by a single nonlinear equation with one adjustable parameter d. When d is large enough the equation is linearly unstable and fairly reproduces a growth process where the initial walls expand, branch and merge, while progressively invading all the available space, which is consistent with the intricate structures of real nests. Interestingly, the linear problem associated to our growth equation is analogous to the buckling of a thin elastic plate under symmetric in-plane compression which is also known to produce rich pattern through non linear and secondary instabilities. We validated our model by collecting nests of two species of arboreal Nasutitermes from the field and imaging their structure with a micro-CT scanner. We found a strong resemblance between real and simulated nests, characterised by the emergence of a characteristic length-scale and by the abundance of saddle-shaped surfaces with zero-mean curvature which validates the choice of the driving mechanism of our growth model., Comment: 24 pages 6 figures + 9 pages supplementary material
- Published
- 2020
232. Covering classes and uniserial modules
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Facchini, Alberto, Nazemian, Zahra, and Prihoda, Pavel
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Mathematics - Rings and Algebras ,Primary 16P70, 16S50. Secondary 16W80 - Abstract
We apply minimal weakly generating sets to study the existence of Add$(U_R)$-covers for a uniserial module $U_R$. If $U_R$ is a uniserial right module over a ring $R$, then $S:=$End$ (U_R)$ has at most two maximal (right, left, two-sided) ideals: one is the set $I$ of all endomorphisms that are not injective, and the other is the set $K $ of all endomorphisms of $U_R$ that are not surjective. We prove that if $U_R$ is either finitely generated, or artinian, or $I \subset K$, then the class Add$(U_R)$ is covering if and only if it is closed under direct limit. Moreover, we study endomorphism rings of artinian uniserial modules giving several examples.
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- 2020
233. CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
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Mallardo, Domenico, Fordellone, Mario, White, Andrew, Ottaviano, Margaret, Sparano, Francesca, Bailey, Michael, Facchini, Arianna Bianca, Ong, Sufey, Maiolino, Piera, Caracò, Corrado, Church, Sarah, Cavalcanti, Ernesta, Warren, Sarah, Budillon, Alfredo, Cesano, Alessandra, Simeone, Ester, Chiodini, Paolo, and Ascierto, Paolo Antonio
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- 2023
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234. Exposure to urban nanoparticles at low PM1 concentrations as a source of oxidative stress and inflammation
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Costabile, Francesca, Gualtieri, Maurizio, Rinaldi, Matteo, Canepari, Silvia, Vecchi, Roberta, Massimi, Lorenzo, Di Iulio, Gianluca, Paglione, Marco, Di Liberto, Luca, Corsini, Emanuela, Facchini, Maria Cristina, and Decesari, Stefano
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- 2023
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235. Exploring hematic crasis variations in cancer patients following SARS-CoV-2 vaccination: a real-practice study
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Montella, Liliana, Dell’Aversana, Carmela, Pacella, Daniela, Troise, Simona, Russo, Paola, Cacciapuoti, Valentina, Ottaiano, Alessandro, Di Marino, Luigi, Coppola, Paola, Liguori, Carmela, Berretta, Massimiliano, Maddaluno, Salvatore, Altucci, Lucia, and Facchini, Gaetano
- Published
- 2023
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236. The dynamic functional connectivity fingerprint of high-grade gliomas
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Moretto, Manuela, Silvestri, Erica, Facchini, Silvia, Anglani, Mariagiulia, Cecchin, Diego, Corbetta, Maurizio, and Bertoldo, Alessandra
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- 2023
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237. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)
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Menéndez-Perdomo, Ivette M. and Facchini, Peter J.
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- 2023
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238. Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study
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Masala, Giovanna, Bendinelli, Benedetta, Caini, Saverio, Duroni, Giacomo, Ermini, Ilaria, Pastore, Elisa, Fontana, Miriam, Facchini, Luigi, Querci, Andrea, Gilio, Maria Antonietta, Mazzalupo, Vincenzo, Assedi, Melania, Ambrogetti, Daniela, and Palli, Domenico
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- 2023
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239. Non-reactive test rig for combustor-turbine interaction studies in industrial gas turbines
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Fiorineschi, Lorenzo, Bacci, Tommaso, Frillici, Francesco Saverio Saverio, Cubeda, Simone, Volpe, Yary, Rotini, Federico, Carfagni, Monica, and Facchini, Bruno
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- 2023
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240. Biological Properties and Genetic Characterization of Novel Low Pathogenic H7N3 Avian Influenza Viruses Isolated from Mallard Ducks in the Caspian Region, Dagestan, Russia.
- Author
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Gulyaeva, Marina, De Marco, Maria, Kovalenko, Ganna, Bortz, Eric, Murashkina, Tatiana, Yurchenko, Kseniya, Facchini, Marzia, Delogu, Mauro, Sobolev, Ivan, Gadzhiev, Alimurad, Sharshov, Kirill, and Shestopalov, Alexander
- Subjects
Caspian region ,H7N3 ,avian influenza virus ,wild waterfowl - Abstract
Avian influenza viruses (AIVs) are maintained in wild bird reservoirs, particularly in mallard ducks and other waterfowl. Novel evolutionary lineages of AIV that arise through genetic drift or reassortment can spread with wild bird migrations to new regions, infect a wide variety of resident bird species, and spillover to domestic poultry. The vast continental reservoir of AIVs in Eurasia harbors a wide diversity of influenza subtypes, including both highly pathogenic (HP) and low pathogenic (LP) H7 AIV. The Caspian Sea region is positioned at the intersection of major migratory flyways connecting Central Asia, Europe, the Black and Mediterranean Sea regions and Africa and holds a rich wetland and avian ecology. To understand genetic reservoirs present in the Caspian Sea region, we collected 559 cloacal swabs from Anseriformes and other species during the annual autumn migration periods in 2017 and 2018. We isolated two novel H7N3 LPAIV from mallard ducks whose H7 hemagglutinin (HA) gene was phylogenetically related to contemporaneous strains from distant Mongolia, and more closely Georgia and Ukraine, and predated the spread of this H7 LPAIV sublineage into East Asia in 2019. The N3 neuraminidase gene and internal genes were prototypical of AIV widely dispersed in wild bird reservoirs sampled along flyways connected to the Caspian region. The polymerase and nucleoprotein segments clustered with contemporaneous H5 HPAI (clade 2.3.4.4b) isolates, suggesting the wide dispersal of H7 LPAIV and the potential of this subtype for reassortment. These findings highlight the need for deeper surveillance of AIV in wild birds to better understand the extent of infection spread and evolution along spatial and temporal flyways in Eurasia.
- Published
- 2021
241. The use of Information and Communication Technologies in Primary Health Care in Brazil - the period of 2014 to 2018
- Author
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Bender, Janaina Duarte, Facchini, Luiz Augusto, Lapao, Luis Miguel Velez, Tomasi, Elaine, and Thume, Elaine
- Published
- 2024
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242. Trends in the quality of child health care in the first week of life in primary care services in Brazil
- Author
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del Pilar Flores-Quispe, Maria, Silva Duro, Suele Manjourany, Facchini, Luiz Augusto, Rios Barros, Nicole Borba, and Tomasi, Elaine
- Published
- 2024
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243. The dynamic functional connectivity fingerprint of high-grade gliomas
- Author
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Manuela Moretto, Erica Silvestri, Silvia Facchini, Mariagiulia Anglani, Diego Cecchin, Maurizio Corbetta, and Alessandra Bertoldo
- Subjects
Medicine ,Science - Abstract
Abstract Resting state fMRI has been used in many studies to investigate the impact of brain tumours on functional connectivity (FC). However, these studies have so far assumed that FC is stationary, disregarding the fact that the brain fluctuates over dynamic states. Here we utilised resting state fMRI data from 33 patients with high-grade gliomas and 33 healthy controls to examine the dynamic interplay between resting-state networks and to gain insights into the impact of brain tumours on functional dynamics. By employing Hidden Markov Models, we demonstrated that functional dynamics persist even in the presence of a high-grade glioma, and that patients exhibited a global decrease of connections strength, as well as of network segregation. Furthermore, through a multivariate analysis, we demonstrated that patients’ cognitive scores are highly predictive of pathological dynamics, thus supporting our hypothesis that functional dynamics could serve as valuable biomarkers for better understanding the traits of high-grade gliomas.
- Published
- 2023
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244. Síndrome de Poland
- Author
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Chavoin, J.-P., Facchini, F., Schirmer, C., Chanel, L., Grolleau, J.-L., Leyx, P., and Chaput, B.
- Published
- 2023
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245. Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells
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Matsuoka, Sahoko, Facchini, Raffaella, Luis, Tiago C., Carrelha, Joana, Woll, Petter S., Mizukami, Takuo, Wu, Bishan, Boukarabila, Hanane, Buono, Mario, Norfo, Ruggiero, Arai, Fumio, Suda, Toshio, Mead, Adam J., Nerlov, Claus, and Jacobsen, Sten Eirik W.
- Published
- 2023
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246. A cane toad (Rhinella marina) N-methyltransferase converts primary indolethylamines to tertiary psychedelic amines
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Chen, Xue, Li, Jing, Yu, Lisa, Maule, Francesca, Chang, Limei, Gallant, Jonathan A., Press, David J., Raithatha, Sheetal A., Hagel, Jillian M., and Facchini, Peter J.
- Published
- 2023
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247. An open data index to assess the green transition - A study on all Italian municipalities
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Muscillo, Alessio, Re, Simona, Gambacorta, Sergio, Ferrara, Giuseppe, Tagliafierro, Nicola, Borello, Emiliano, Rubino, Alessandro, and Facchini, Angelo
- Published
- 2023
- Full Text
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248. ACACIAS 1: The physiological and subjective impacts of high fidelity simulation of the breaking of bad news
- Author
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Deluche, E., Salle, H., Leobon, S., Facchini-Joguet, T., Fourcade, L., and Taibi, A.
- Published
- 2023
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249. ACACIAS 1 : impacts physiologiques et subjectifs de la simulation haute-fidélité lors de l’annonce de mauvaises nouvelles
- Author
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Deluche, Elise, Salle, Henri, Leobon, Sophie, Facchini-Joguet, Teeva, Fourcade, Laurent, and Taibi, Abdelkader
- Published
- 2023
- Full Text
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250. Effects of Saccharomyces cerevisiae and Starmerella bacillaris on the physicochemical and sensory characteristics of sparkling pear cider (Perry)
- Author
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Guerrini, Simona, Galli, Viola, Barbato, Damiano, Facchini, Giulio, Mangani, Silvia, Pierguidi, Lapo, and Granchi, Lisa
- Published
- 2023
- Full Text
- View/download PDF
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