The aims of this research were to:(1) provide a theoretical basis for in-depth analysis of the influence of human activities on estuarine wetlands over a regional scale;(2) quantify the impact of anthropogenic interference on the landscape pattern index;and(3) establish a theoretical basis for the monitoring and evaluation of anthropogenic interference in estuarine wetlands.Based on aerial photographs from 1958,1970,and 1984(2 m resolution),and the spot5 image of 2008(5 m resolution),this study explored the spatiotemporal dynamics of hemeroby and the landscape pattern response scheme through hemeroby analysis,landscape pattern analysis,spatial patch analysis,and GIS spatial analysis in the Dayang estuary.The research evaluates: 1) the primary forcing landscape factors for spatial and temporal variation of hemeroby in an estuarine wetland;2) the response mechanism of landscape pattern index on the type of hemeroby;and 3) landscape indices associated with hemeroby in space.Results indicate that: 1) completely hemeroby regions increased from 4.16 km2 in 1958 to 9.16 km2 in 2008,while partially hemeroby regions increased from 115.82 km2 to 180.57 km2,and hemeroby regions declined from 291.23 km2 to 221.13 km2.Historically,hemeroby showed heterogeneous changes.The center of hemeroby moved gradually from land to ocean,and ocean aquaculture is the main driving factor in the change of hemeroby.Over time,hemeroby shows an upward trend,but the intensity of hemeroby changes are different at different historical periods,and hemeroby shows non-homogeneous characteristics at different historical periods.Comparing the change in different landscape types,we found paddy yield was the primary landscape type in 1958,aquaculture water in ocean and farmland showed upward increases in 1970,and after the 1980s aquaculture water in the ocean was the primary landscape type of human activities.Temporally,anthropogenic disturbance has led to an overall decrease in the number of patches(NP),edge density(ED),mean shape index(MSI),and area-weighted mean patch fractal dimension(AWMPFD) between 1958 and 2008.Through analysis of the landscape pattern index of different hemeroby types,we found that human disturbance has a certain effect on the landscape pattern index.Spatially,hemeroby is positively correlated with number of patches(NP),edge density(ED),and area-weighted mean patch fractal dimension(AWMPFD) in order of decreasing influence,while it is not significantly correlated with the mean shape index(MSI).The relationship between human disturbance activities and landscape pattern(four indices: number of patches(NP),edge density(ED),area-weighted mean patch fractal dimension(AWMPFD),mean shape index(MSI)) constituted differences in time and space within estuarine areas.Thus,heterogeneity and complexity of the landscape were greater in human disturbance areas over some time intervals,and heterogeneity and complexity of landscape showed declines in the continuing role of human disturbance with time.Therefore,the dimension of time and space should be distinguished in remote sensing monitoring responses of landscape patterns on human activities in estuarine wetlands.