934 results on '"Duvvuri, Umamaheswar"'
Search Results
202. Transoral robotic surgical resection followed by randomization to low- or standard-dose IMRT in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN Cancer Research Group (E3311).
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Ferris, Robert L., primary, Flamand, Yael, additional, Weinstein, Gregory S., additional, Li, Shuli, additional, Quon, Harry, additional, Mehra, Ranee, additional, Garcia, Joaquin J., additional, Chung, Christine H., additional, Gillison, Maura L., additional, Duvvuri, Umamaheswar, additional, O'malley, Bert W., additional, Ozer, Enver, additional, Thomas, Giovana R., additional, Koch, Wayne, additional, Kupferman, Michael Elliot, additional, Bell, Richard Bryan, additional, Saba, Nabil F., additional, Lango, Miriam, additional, Mendez, Eduardo, additional, and Burtness, Barbara, additional
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- 2020
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203. Distinct B cell signatures and tertiary lymphoid structures are driven by two etiol-ogies in head and neck cancer
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Ruffin, Ayana T, primary, Cillo, Anthony R, additional, Tabib, Tracey, additional, Liu, Angen, additional, Onkar, Sayali, additional, Kunning, Sheryl, additional, Lampfield, Caleb, additional, Abecassis, Irina, additional, Qi, Zengbiao, additional, Soose, Ryan, additional, Duvvuri, Umamaheswar, additional, Kim, Seungwon, additional, Lafyatis, Robert, additional, Ferris, Robert L, additional, Vignali, Dario, additional, and Bruno, Tullia C, additional
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- 2020
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204. Major head and neck reconstruction during the COVID‐19 pandemic: The University of Pittsburgh approach
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Ranasinghe, Viran, primary, Mady, Leila J., additional, Kim, Seungwon, additional, Ferris, Robert L., additional, Duvvuri, Umamaheswar, additional, Johnson, Jonas T., additional, Solari, Mario G., additional, Sridharan, Shaum, additional, and Kubik, Mark, additional
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- 2020
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205. Transition to a virtual multidisciplinary tumor board during the COVID ‐19 pandemic: University of Pittsburgh experience
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Dharmarajan, Harish, primary, Anderson, Jennifer L., additional, Kim, Seungwon, additional, Sridharan, Shaum, additional, Duvvuri, Umamaheswar, additional, Ferris, Robert L., additional, Solari, Mario G., additional, Clump, David A., additional, Skinner, Heath D., additional, Ohr, James P., additional, Zandberg, Dan P., additional, Branstetter, Barton, additional, Hughes, Marion A., additional, Traylor, Katie S., additional, Seethala, Raja, additional, Chiosea, Simion I., additional, Nilsen, Marci L., additional, Johnson, Jonas T., additional, and Kubik, Mark W., additional
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- 2020
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206. Quality and Readability Assessment of Websites on Human Papillomavirus and Oropharyngeal Cancer
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Schwarzbach, Hannah L., primary, Mady, Leila J., additional, Kaffenberger, Thomas M., additional, Duvvuri, Umamaheswar, additional, and Jabbour, Noel, additional
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- 2020
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207. TORS Base‐of‐Tongue Mucosectomy in Human Papilloma Virus‐Negative Carcinoma of Unknown Primary
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Kubik, Mark W., primary, Channir, Hani I., additional, Rubek, Niclas, additional, Kim, Seungwon, additional, Ferris, Robert L., additional, Buchwald, Christian, additional, and Duvvuri, Umamaheswar, additional
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- 2020
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208. Long-Term Patient-Reported Quality of Life After Stereotactic Body Radiation Therapy for Recurrent, Previously-Irradiated Head and Neck Cancer
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Thomas, Joel, primary, Wang, Hong, additional, Clump, David A., additional, Ferris, Robert L., additional, Duvvuri, Umamaheswar, additional, Ohr, James, additional, and Heron, Dwight E., additional
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- 2020
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209. Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer
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Cillo, Anthony R., primary, Kürten, Cornelius H.L., additional, Tabib, Tracy, additional, Qi, Zengbiao, additional, Onkar, Sayali, additional, Wang, Ting, additional, Liu, Angen, additional, Duvvuri, Umamaheswar, additional, Kim, Seungwon, additional, Soose, Ryan J., additional, Oesterreich, Steffi, additional, Chen, Wei, additional, Lafyatis, Robert, additional, Bruno, Tullia C., additional, Ferris, Robert L., additional, and Vignali, Dario A.A., additional
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- 2020
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210. Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity
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Vyas, Avani, primary, Duvvuri, Umamaheswar, additional, and Kiselyov, Kirill, additional
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- 2019
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211. Genomic Correlates of Exceptional Response to ErbB3 Inhibition in Head and Neck Squamous Cell Carcinoma
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Faden, Daniel L., primary, Gomez-Casal, Roberto, additional, Alvarado, Diego, additional, and Duvvuri, Umamaheswar, additional
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- 2019
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212. Sinusitis
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Ferguson, Berrylin, primary and Duvvuri, Umamaheswar, additional
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- 2006
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213. Transoral robotic surgery adoption and safety in treatment of oropharyngeal cancers.
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Oliver, Jamie R., Persky, Michael J., Wang, Binhuan, Duvvuri, Umamaheswar, Gross, Neil D., Vaezi, Alec E., Morris, Luc G. T., and Givi, Babak
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SURGICAL robots ,OROPHARYNGEAL cancer ,CANCER treatment ,SQUAMOUS cell carcinoma - Abstract
Background: Transoral robotic surgery (TORS) was approved by the Food and Drug Administration in 2009 for the treatment of oropharyngeal cancers (oropharyngeal squamous cell carcinoma [OPSCC]). This study investigated the adoption and safety of TORS. Methods: All patients who underwent TORS for OPSCC in the National Cancer Data Base from 2010 to 2016 were selected. Trends in the positive margin rate (PMR), 30‐day unplanned readmission, and early postoperative mortality were evaluated. Outcomes after TORS, nonrobotic surgery (NRS), and nonsurgical treatment were compared with matched‐pair survival analyses. Results: From 2010 to 2016, among 73,661 patients with OPSCC, 50,643 were treated nonsurgically, 18,024 were treated with NRS, and 4994 were treated with TORS. TORS utilization increased every year from 2010 (n = 363; 4.2%) to 2016 (n = 994; 8.3%). The TORS PMR for base of tongue malignancies decreased significantly over the study period (21.6% in 2010‐2011 vs 15.8% in 2015‐2016; P =.03). The TORS PMR at high‐volume centers (≥10 cases per year; 11.2%) was almost half that of low‐volume centers (<10 cases per year; 19.3%; P <.001). The rates of 30‐day unplanned readmission (4.1%) and 30‐day postoperative mortality (1.0%) after TORS were low and did not vary over time. High‐volume TORS centers had significantly lower rates of 30‐day postoperative mortality than low‐volume centers (0.5% vs 1.5%; P =.006). In matched‐pair analyses controlling for clinicopathologic cofactors, 30‐, 60‐, and 90‐day posttreatment mortality did not vary among patients with OPSCC treated with TORS, NRS, or nonsurgical treatment. Conclusions: TORS has become widely adopted and remains safe across the country with a very low risk of severe complications comparable to the risk with NRS. Although safety is excellent nationally, high‐volume TORS centers have superior outcomes with lower rates of positive margins and early postoperative mortality. Transoral robotic surgery (TORS) has become widely adopted and remains safe across the country with a very low risk of severe complications comparable to the risk with nonrobotic surgery. Although safety is excellent nationally, high‐volume TORS centers have superior outcomes with lower rates of positive margins and early postoperative mortality. [ABSTRACT FROM AUTHOR]
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- 2022
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214. Esthesioneuroblastoma: University of Pittsburgh Experience
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Duvvuri, Umamaheswar, Carrau, Ricardo L., Snyderman, Carl H., and Kassam, Amin B.
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- 2005
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215. METASTATIC ADENOCARCINOMA OF THE COLON PRESENTING AS A MASS IN THE MANDIBLE
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Mason, Corde A., Azari, Kodi K., Farkas, Linda M., Duvvuri, Umamaheswar, and Myers, Eugene N.
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- 2005
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216. Profiling the Stromal and Vascular Heterogeneity in Patient-derived Xenograft Models of Head and Neck Cancer: Impact on Therapeutic Response
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Folaron, Margaret, Merzianu, Mihai, Duvvuri, Umamaheswar, Ferris, Robert L., Seshadri, Mukund, Folaron, Margaret, Merzianu, Mihai, Duvvuri, Umamaheswar, Ferris, Robert L., and Seshadri, Mukund
- Abstract
Head and neck squamous cell carcinomas (HNSCC) represent a group of epithelial neoplasms that exhibit considerable heterogeneity in clinical behavior. Here, we examined the stromal and vascular heterogeneity in a panel of patient-derived xenograft (PDX) models of HNSCC and the impact on therapeutic response. Tumor sections from established tumors were stained for p16 (surrogate for human papillomavirus (HPV) infection), stromal (Masson’s trichrome) and vascular (CD31) markers. All PDX models retained the HPV/p16 status of the original patient tumor. Immunohistochemical evaluation revealed the presence of multiple vessel phenotypes (tumor, stromal or mixed) in the PDX panel. Vascular phenotypes identified in the PDX models were validated in a tissue microarray of human HNSCC. Treatment with a microtubule targeted vascular disrupting agent (VDA) resulted in a heterogeneous antivascular and antitumor response in PDX models. The PDX with the tumor vessel phenotype that exhibited higher CD31+ vessel counts and leaky vasculature on magnetic resonance imaging (MRI) was sensitive to VDA treatment while the PDX with the stromal vessel phenotype was resistant to therapy. Collectively, our results demonstrate the phenotypic and functional vascular heterogeneity in HNSCC and highlight the impact of this heterogeneity on response to antivascular therapy in PDX models of HNSCC
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- 2019
217. 61 - Management of the Unknown Primary Cancer
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Mehta, Vikas and Duvvuri, Umamaheswar
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- 2018
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218. 55 - Volumetric Tongue-Base Reduction (Lingual Tonsillectomy, Coblation Midline Glossectomy, Trans Oral Robotic Surgery)
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Keamy, Don, Jr. and Duvvuri, Umamaheswar
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- 2018
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219. 15 - Supraglottic Transoral Robotic Surgery
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Byrd, J. Kenneth and Duvvuri, Umamaheswar
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- 2018
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220. B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma.
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Ruffin, Ayana T., Cillo, Anthony R., Tabib, Tracy, Liu, Angen, Onkar, Sayali, Kunning, Sheryl R., Lampenfeld, Caleb, Atiya, Huda I., Abecassis, Irina, Kürten, Cornelius H. L., Qi, Zengbiao, Soose, Ryan, Duvvuri, Umamaheswar, Kim, Seungwon, Oesterrich, Steffi, Lafyatis, Robert, Coffman, Lan G., Ferris, Robert L., Vignali, Dario A. A., and Bruno, Tullia C.
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SQUAMOUS cell carcinoma ,TERTIARY structure ,PAPILLOMAVIRUS diseases ,HUMORAL immunity ,T cells ,NECK - Abstract
Current immunotherapy paradigms aim to reinvigorate CD8
+ T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in head and neck squamous cell carcinoma (HNSCC) caused by human papillomavirus infection (HPV+ ), patients have transcriptional signatures of germinal center (GC) tumor infiltrating B cells (TIL-Bs) and spatial organization of immune cells consistent with tertiary lymphoid structures (TLS) with GCs, both of which correlate with favorable outcome. GC TIL-Bs in HPV+ HNSCC are characterized by distinct waves of gene expression consistent with dark zone, light zone and a transitional state of GC B cells. Semaphorin 4a expression is enhanced on GC TIL-Bs present in TLS of HPV+ HNSCC and during the differentiation of TIL-Bs. Our study suggests that therapeutics to enhance TIL-B responses in HNSCC should be prioritized in future studies to determine if they can complement current T cell mediated immunotherapies. Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcinoma and demonstrate that TLS with germinal centres are associated with better survival. [ABSTRACT FROM AUTHOR]- Published
- 2021
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221. Contributory presentations/posters
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Gries, A., Singh, Balwinder, Nakazawal, Chicko, Genest, D., Getzoff, E. D., Matsuo, H., Kaur, Harpreet, Borst, J. W., Chadha, K. C., Tingyun, Kuang, Jagannadham, M. V., Leijon, Mikael, Sato, S., Bhakuni, Vlnod, Vijayan, M., Surolia, A., Suguna, K., Manoj, N., Srinivas, V. R., Ravishankar, R., Laggner, P., Prassl, R., Schwarzenbacher, R., Zeth, K., Kostner, G. M., Taylor, Susan S., Xuong, Nguyen-huu, Akamine, Pearl, Sagar, Bidva M., Saikrishnan, K., Purnapatre, K., Handa, P., Roy, S., Varshney, U., Biswal, B. K., Sukumar, N., Rao, J. K. Mohana, Johnson, A., Pattabhi, Vasantha, Murthy, M. R. N., Krishna, Sri S., Savithri, H. S., Sastri, Mira, Hosur, M. V., Pillai, Bindu, Kannan, K. K., Kumar, Mukesh, Patwardhan, Swati, Padmanabhaa, B., Sasaki-Sugio, S., Matsuzaki, T., Nukaga, M., Singh, T. P., Sharma, A. K., Srinivasan, A., Khan, J. A., Paramasivam, M., Kumar, P., Karthikevan, S., Sharma, S., Yadav, S., Srintvasan, A., Alam, Neelima, Gourinath, S., Kaur, Punit, Chandra, Vikas, Betzel, Ch., Ghosh, S., Bera, A. K., Pal, A. K., Baneriee, Asok, Mukhopadhyay, B. P., Bhattacharya, S., Chakraborty, S., Haldar, U., Dey, I., Solovicova, Adriana, Sevcik, Jozef, Sekar, K., Sundaralingam, M., Genov, N., Liang, Dong-cai, Zhang, Ji-ping, Jiang, Tao, Chang, Wen-rui, Blommers, Marcel, Jahnke, Wolfgang, Hosur, R. V., Panchal, S. C., Pillay, Bindu, Jaganathan, N. R., Mathur, Puniti, Srivatsun, S., Joshi, Ratan Mani, Chauhan, V. S., Govil, Girjesh, Atreya, H. S., Sahu, S. C., Quinjou, Éric, Adjadj, Elisabeth, Mispelter, Joël, Izadi-Pruneyre, Nadia, Blouquit, Yves, Heyd, Bernadette, Lerat, Guilhem, Desmadreil, Michel, Milnard, Philippe, Lin, Y., Rao, B. D. Nageswara, Raghunathan, Vidva, Chau, Mei H., Coutinho, Evans, Pesais, Prashant, Srivastava, Sudha, Saran, Anil, Srikrishnan, Thamarapu, Lijima, Herbert, Gesme, Jayson, Sapico, Leizl F., Paxton, Raymond, Grace, C. R., Nagenagowda, G., Lynn, A. M., Cowsik, Sudha M., Govil, G., Sahu, Sarata C., Bhattacharya, A., Chauhan, S., Kumar, Anil, Zuiderweg, Erik R. P., Pellecchia, Maurizio, Nitta, Katsutoshi, Ohnishi, Atsushi, Kawano, Keiichi, Hikichi, Kunio, Fujitani, Naoki, Ohkubo, Tadayasu, Aizawa, Tomoyasu, Kumaki, Yasuhiro, Hayakawa, Yoichi, Parvathy, Rani V., Kini, R. M., Nakagawa, Astushi, Tanaka, Isao, Demura, Makoto, Yao, Min, Koshiba, Takumi, Kobashigawa, Yoshihiro, Kuwajima, Kunihiro, Linge, Jens, Nilges, Michael, Donoghue, Seán O., Chakshusmathi, G., Ratnaparkhi, Girish S., Madhu, P. K., Varadarajan, R., Tetreau, C., Tourbez, M., Lavalette, D., Bulone, D., Manno, M., Emanuele, A., Palma-Vittorelli, M. B., Palma, M. U., Vaiana, S. M., Martorana, V., Biagio, P. L. San, Chang, D. K., Cheng, S. F., Yang, S. H., Francis, S., Trivedi, V. D., Chien, W. J., Manstein, Dietmar J., Batra, Renn, Geeves, Michael A., Geller, Maciej, Trvlska, Joanna, Grochowski, Pawel, Lesyng, B., Ginalski, K., Grochowski, P., Lavalette, P., Blouquit, Y., Roccatano, D., Berendsen, H. J. C., Amadei, A., Nola, Di A., Ho, Bosco, Curmi, P. M. G., Berry, H., Pelta, J., Pauthe, E., Lairez, D., Srinivasan, M., Sahi, Shakti, Kothekar, V., Madhusudnan, Kartha S., Nandel, Fateh S., Jain, D. V. S., Berendsen, Herman J. C., Feenstra, Anton K., Tama, F., Sanejouand, Y.-H., Go, N., Sharma, Deepak, Pasha, Santosh, Sharma, Sunita, Brahmachari, Samir K., Makker, Jyoti, Viiavaraghavan, R., Kumar, S., Dey, Sharmisllia, Krishnamoorthy, G., Lakshmikanth, G. S., Zaitseva, E. M., Mazhul, V. M., Kierdaszuk, Borys, Widengren, J., Rigler, R., Terry, B., Mets, Ü., Swaminathan, R., Yathindra, N., Thamotharan, S., Chosrowjan, H., Mataga, N., Shibata, Y., Morisima, I., Xiao, Ming, Selvin, Paul, Chakraharty, Tania, Cooke, Roger, Faraone, A., Branca, C., Maisano, G., Migliardo, P., Magazù, S., Villari, V., Behere, Digambar V., Deva, Sharique Zahida Waheed M., Vallone, B., Savino, C., Travaglini-Allocatelli, C., Cutruzzolà, F., Brunori, M., Gibson, Q. H., Mazumdar, Shyamalava, Mitra, Samaresh, Prasad, Swati, Soto, P., Fayad, R., Tyulkova, N. A., Sukovataya, I. E., Mamedov, Sh. V., Aksakal, B., Canturk, M., Aktas, B., Yilgin, R., Bogutska, K. I., Miroshnichenko, N. S., Wein, A. J., Hypolite, J. A., DiSanto, M., Chacko, S., Zheng, Y-M., Antosiewicz, J., Wojciechowski, M., Grycuk, T., Di Nola, Alfredo, Ceruso, Marc A., Chatterjee, Bishnu P., Bandvopadhvay, Subhasis, Choudhury, Devapriva, Khight, Stefan, Thompson, Andrew, Stojanoff, Vivian, Pinkner, Jerome, Hultgren, Scott, Flatters, Delphine, Goodfellow, Julia, Takazawatt, Fumi, Kanehisa, Minoru, Sasai, Masaki, Nakamura, Hironori, Wang, Bao Han, Pan, xin Min, Zheng, Yuan, Wang, Zhi Xin, Ahmad, Atta, Kulkarni, Sangeeta, Prakash, Koodathingal, Prajapati, Shashi, Surin, Alexey, Kihara, Hiroshi, Yang, Li, Matsumoto, Tomoharu, Nakagawa, Yuki, Semisotnov, Gennady V., Kimura, Kazumoto, Amemiya, Yoshiyuki, Tayyab, Saad, Muzammil, Salman, Kumar, Yogesh, Bhakuni, Vinod, Sundd, Monica, Kundu, Suman, Jagannadham, Medicherla V., Chandani, Bina, Warrier, Deepti, Sinha, Lalankumar, Dhar, Ruby, Mehrotra, Sonam, Khandelwal, Purnima, Seth, Subhendu, Gidwani, Arun, Prabha, Ratna C., Sasidhar, Y. U., Madhusudan, K. P., Nishikawa, Ken, Kinjo, Akira R., Varadarajan, Raghavan, Chakravarty, Suvobrata, Van Dael, H., Noyelle, K., Joniau, M., Haezebrouck, P., Jha, Indra Brata, Bhat, Rajiv, Dash, Sheffali, Mohanty, Prasanna, Bandyopadhyay, A. K., Sonawat, H. M., Rao, Ch. Mohan, Datta, Siddhartha, Raman, B., Rajaraman, K., Ramakrishna, T., Pande, A., Benedek, G., King, J., Betts, S., Pande, J., Asherie, N., Ogun, O., Kalacheva, G. S., Sokolova, I. V., Mitaku, Shigeki, Sonoyama, Masashi, Taira, Kunihiro, Yokoyama, Yasunori, Sasakil, Takanori, Kamo, Naoki, Mukai, Yuri, Dalal, Seema, Regan, Lynne, Mituku, Shigeki, Kumar, Devesh, Roychoudhury, Mihir, Lőrinczv, Dénes, Könczöl, Franciska, Farkas, László, Belagyi, Joseph, Schick, Christoph, Thomson, Christy A., Ananthanarayanan, Vettai S., Alirzayeva, E. G., Baba-Zade, S. N., Sarai, A., Kono, H., Uedaira, H., An, J., Gromiha, Michael M., Oobatake, M., Yutani, Katsuhide, Takano, Kazufumi, Yamagata, Yuriko, Jas, Gouri S., Hofrichter, James, Muñoz, Victor, Eaton, William A., Penoyar, Jonathan, Lo Verde, Philip T., Bódi, Á., Venekei, I., Kardos, J., Gráf, L., Závodszky, P., Szilágyi, András, Závodszky, Péter, Woolfson, D. N., Walshaw, J., Allan, R. D., Funahashi, Jun, Gupta, Savan, Di Nola, A., Mangoni, M., Roccatano, P., Ramachandraiah, Gosu, Chandra, Nagasuma R., Ciani, Barbara, Woolfson, Derek N., Nair, Usha B., Salunke, Dinakar M., Kaur, Kanwal J., Swaminathan, Chittoor P., Surolia, Avadhesha, Pramanik, A., Jörnvall, H., Nygren, P.-Å., Jonasson, P., Ståhl, S., Johansson, B.-L., Kratz, G., Wahren, J., Ekberg, K., Uhlén, M., Jansson, O. T., Uhlén, S., Misselwitz, Rolf, Welfle, Heinz, Welfle, Karin, Höhne, Wolfgang, Kurganov, B. I., Mitskevich, L. G., Fedurkina, N. V., Jarori, Gotam K., Maity, Haripada, Guharay, J., Sengupta, P. K., Sengupta, B., Sridevi, K., Kasturi, S. R., Gupta, S. P., Agarwal, Gunjan, Briehl, Robin W., Kwong, Suzanne, Tyulkova, N A., Ismailova, O. I., Parola, A. H., Yayon, A., Hariharan, C., Pines, D., Pines, E., Zamai, M., Cohen-Luria, R., Woolfeon, D. N., Spooner, G. A., Padya, M. J., Bharadwaj, D. K., Bakshi, Panchan, Jagannathan, N. R., Sharma, U., Srivastava, N., Barthwal, R., Matsuda, Keiko, Nishioka, Takaaki, Go, Nobuhiro, Urata, S., Aita, T., Husimi, Y., Majumder, Mainak, Subirana, Juan A., Malinina, Lucy, Abrescia, Nicola G. A., Aymami, Juan, Coll, Miquel, Eritxa, Ramón, Premraj, B. J., Thenmalarchelvi, R., Gautham, N., Kumar, Satheesh P., Kan, Lou-Sing, Hou, Ming, Lin, Shwu-Bin, Roy, Kanal B., Sana, Tapas, Bruant, N., Flatters, D., Lavery, R., Sklenar, Heinz, Rons, Remo, Lavery, Richard, Thakur, Ashoke Ranjan, Kundu, Sudip, Bandyopadhyay, Debashree, Bhattacharyya, Dhananjay, Majumdar, Rabi, Barceló, F., Portugal, J., Rao, B. J., Ramanathan, Sunita, Gliosli, Mahua, Varshney, Umesh, Kumar, Vinay N., Pataskar, Shashank S., Sarojini, R., Selvasekarapandian, S., Kolandaivel, P., Sukumar, S., Kolmdaivel, P., Maiti, Motilal, Das, Suman, Sen, Anjana, Xodo, Luigi, Suraci, Chiara, Del Terra, Elisa, Quadrifoglio, Franco, Diviacco, Silvia, Ray, Arghya, Rao, Basuthkar J., Karthikeyan, G., Chary, Kandala V. R., Mujeeb, Anwer, James, Thomas L., Bogdanov, A., Zanina, A., Haya, E. E. F., Kasyanenko, N., Cornélio, M. L., Bugs, M. R., Tolstorukov, Ye. M., Sanval, Nitish K., Tiwari, S. N., Sanyal, Nitish K., Choudhury, Mihir Roy, Patel, P. K., Bhavesh, Neel S., Gabrielian, Anna, Rigler, Rudolf, Edman, Lars, Wennmalm, Stefan, Constantinescu, B., Gazdaru, D., Radulcscu, I., Radu, L., Wärmländer, Sebastian, Aoki, Setsuyuki, Ishiura, Masahiro, Kondo, Takao, Pashinskaya, V. A., Kosevich, M. V., Shelkovsky, V. S., Blagoy, Yu. P., Wang, Ji-hua, Malathi, R., Chandrasekhar, K., Kandimalla, E. R., Agrawal, S., Rastogi, V. K., Palafox, Alcolea M., Singh, Chatar, Beniaminov, A. D., Minyat, E. E., Zdobnov, E. M., Ulyanov, N. B., Bondarenko, S. A., Ivanov, V. I., Singh, J. S., Tewari, Ravindra, Sonawane, Kailas D., Grosjean, Henri, Sonavane, Uddhavesh B., Morin, Annie, Doherty, Elizabeth A., Doudna, Jennifer A., Tochio, H., Shirakawa, M., Kyogoku, Y., Das, Achintya, Javaram, B., Kalra, Parul, Shukla, Piyush, Dixit, Surjit B., Beveridge, David L., McConnell, Kevin, Davidson, B. E., Chan, R. Y. S., Sawyer, W. H., Eccelston, J. F., Yan, Yuling, Norden, Bengt, Tuite, Eimer, Nielsen, Peter, Takahashi, Masayuki, Ghosh, Anirban, Bansal, Manju, Pingoud, Alfred, Christ, Frauke, Thole, Hubert, Pingoud, Vera, Wende, Wolfgang, Luthra, Pratibha Mehta, Chandra, Ramesh, Sen, Ranjan, Weisberg, Robert, King, Rodney, Gobets, Bas, van Amerongen, Herbert, van Stokkum, Ivo H. M., Larsen, Olaf F. A., van Grondelle, Rienk, Hilbers, Cornelis W., Heus, Hans A., Berends, Jos, Sngrvan, H E., Khudaverdian, N. V., Babayan, Yu. 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R., Hicks, D., Dreyfus, H., Sahel, J., Picaud, S., Forster, V., Wang, Hong-Wei, Sui, Sen-fang, Luther, Pradeep K., Morris, Ed, Barry, John, Squire, John, Sundari, Sivakama C., Balasubramanian, D., Christlet, Hema Thanka T., Veluraia, K., Suresh, Xavier M., Laretta-Garde, V., Krilov, Dubravka, Herak, Janko N., Stojanović, Nataša, Ferrone, Frank A., Ivanova, Maria, Jasuja, Ravi, Mirchev, Rossen, Stopar, David, Wolfs, Cor J. A. M., Hemminga, Marcus A., Spruijt, Ruud B., Arcovito, G., De Spirito, M., Frank, Joachim, Heagle, Amy B., Grassucci, Robert, Penczek, Pawel, Agrawal, Rajendra K., Sharma, Manjuli R., Wagenknecht, Terence, Jeyakumar, Loice H., Fleischer, Sidney, Knupp, Carlo, Squire, John M., Ezra, Eric, Munro, Peter M. G., Kitazawa, Hidefumi, Ichihara, Koji, Itoh, Tomohiko J., Iguchi, Yusuke, Pifat, Greta, Kveder, Marina, Pečar, Slavko, Schara, Milan, Nair, Deepak, Singh, Kavita, Rao, Kanury V. S., Sundaravadivel, B., Jain, Deepti, Kaur, Kanwaljeet, Salunke, D. M., Goel, Manisha, Kovalenko, E. I., Semenkova, G. N., Cherenkevich, S. N., Loganathan, D., Lakshmanan, T., Sriram, D., Srinivasan, S., Lebrón, J. A., Bjorkman, P. J., Ramalingam, T. S., Singh, A. K., Gayatri, T. N., Bisch, Paulo M., Caffarena, Ernesto R., Grigera, Raul J., Fromherz, P., Kiessling, V., Suresh, C. G., Rao, K. N., Khan, M. I., Gaikwad, S. M., Elanthiraiyan, M., Kaliannan, P., Payne, J., Chadha, K., Ambrus, J. L., Nair, M. P. N., Nair, Madhavan P. N., Hewitt, R., Schwartz, S. A., Mahajan, S., Macherel, D., Bourguignon, J., Neuburger, M., Douce, R., Cohen-Addad, C., Faure, M., Ober, R., Sieker, L., Gurumurthy, D. S., Velmurugan, S., Lobo, Z., Phadke, Ratna S., Desai, Prashant, Alieva, D. R., Guseinova, I. M., Zulfugarov, I. S., Aliev, J. A., Ismayilov, M. A., Novruzova, S. N., Savchenko, T. V., Suleimanov, Yu. S., Bartošková, Hana, Nauš, Jan, Ilík, Petr, Kouřil, Roman, Vidyasagar, P. B., Thomas, Sarah, Gaikwad, Jvoti U., Cseh, Z., Mustárdy, L., Garab, G., Simidjiev, I., Rajagopal, S., Várkonyi, Zs., Holzenburg, A., Stoylova, S., Papp, E., Millar, D. P., Bruder, R., Woo, T. T., Genick, U. K., Gerwert, K., Jávorfí, Tamás, Garab, Győző, Naqvi, Razi K., Gaikwad, Jyoti, Kalimullah, Md., Semwal, Manoj, Naus, Man, Ilik, Petr, Kouril, Roman, Horváth, Gábor, Bernard, Gary D., Pomozi, István, Wehner, Rüdiger, Damjanović, Ana, Schulten, Klaus, Ritz, Thorsten, Yandao, Gong, Jushuo, Wang, Nanming, Zhao, Jixiu, Shan, Freiberg, Arvi, Timpmann, Kõu, Woodbury, Neal W., Ruus, Rein, Nemtseva, E. V., Kudryasheva, N. S., Sizykh, A. G., Tikhomirov, A. A., Nesterenko, T. V., Shikhov, V. N., Forti, Giorgio, Furia, Alberto, Finazzi, Giovanni, Barbagallo, Romina Paola, Agalarov, R., Gasanov, R., Iskenderova, S., Nobuhiro, G. O., Osamu, Miyashita, Ramrakhiani, M., Soni, R. K., Yoshida, Masasuke, Akutsu, Hideo, Yagi, Hiromasa, Tozawa, Kacko, Sekino, Nobuaki, Iwabuchi, Tomoyuki, Kaulen, A. 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C., Neagu, Monica, Neagu, Adrian, Janežič, Dušanka, Praprotnik, Matej, Nilsson, Lennart, Mark, Pekka, Fata, La L., Dardenne, Laurent E., Werneck, Araken S., Neto, Marçal de O., Kannan, N., Vishveshwara, S., Veluraja, K., Opitz, David, Balasubramanian, Krishnan, Gute, Brian D., Mills, Denise, Lungeanu, Diana, Mihalas, G. I., Macovievici, G., Gruia, Raluca, Dalcin, B., Cortez-Maghelly, C., Passos, E. P., Ljubisavljevic, M., Blesic, S., Milosevic, S., Stratimirovic, D. J., Bachhawat, Nandita, Mande, Shekhar C., Nandy, A., Nishigaki, Koichi, Saito, Ayumu, Naimuddin, Mohammed, Takaesu, Hirotomo, Ono, Mitsuo, Hirokawa, Takatsugu, Eissa, A. M., Ahmed, Abdalla S., El Gohary, M. I., Nakashima, Hiroshi, Raghava, G. P. S., Kurgalvuk, N., Goryn, O., Gerstman, Bernard S., Kratasyuk, V. A., Esimbekova, E. N., Gritsenko, E. V., Remmel, N. N., Maznyak, O. M., German, A., Tikhonov, A., Tchitchkan, D., Koulchitsky, S., Pashkevich, S., Pletnev, S., Kulchitsky, V., Pesotskaya, Y., Shapiro, Erik M., Borthakur, Arijitt, Dimitrov, Ivan, Leigh, John S., Rizi, Rahim, Reddy, Ravinder, Charagundla, Sridhar, Duvvuri, Umamaheswar, Degaonkar, M., Khubchandani, M., Kumar, Mahesh, Jagannathan, N R., Raghunathan, P., Jayasundar, Rama, Coshic, O., Rath, O. K., Julka, P. K., Iliescu, Karina Roxana, Sajin, Maria, Petcu, Ileana, Moisoi, Nicolcta, Kuzmenko, A. I., Donchenko, G. V., Nikolenko, I. A., Morozova, R. P., Rahman, M. K., Ahmed, M. M., Watanabe, Takehiro, Uretzky, G., Ammar, R., Sharony, R., Rubin, Y., Gilboa, H., Mallick, H. N., Kumar, Mohan V., Begum, Gulnaz M., Degaonkar, Mahaveer N., Govindasamy, S., Kumosani, T. A., Lupusoru, C., Titescu, G., Haulica, I., Stefanescu, I., Iliescu, R., Nastasa, V., Bild, W., Khetawat, Gopal, Nealen, M., Faraday, N., Bray, P. F., Noga, S., Lycholat, E. A., Ananieva, T. V., Kosevich, M V., Stepanyan, S. 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- 1999
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222. Phase 1 study of EGFR-antisense DNA, cetuximab, and radiotherapy in head and neck cancer with preclinical correlatives
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Bauman, Julie E, Duvvuri, Umamaheswar, Thomas, Sufi, Gooding, William E, Clump, David A, Karlovits, Brian, Wehbe, Ahmad, Miller, Frank R, Kim, Seungwon, Sen, Malabika, Heron, Dwight E, Grandis, Jennifer R, and Argiris, Athanassios
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Male ,oligonucleotide ,Cell Survival ,antisense ,Nude ,Oncology and Carcinogenesis ,Cetuximab ,Cell Line ,Mice ,Rare Diseases ,Clinical Research ,Antineoplastic Combined Chemotherapy Protocols ,80 and over ,Animals ,Humans ,Molecular Targeted Therapy ,Oncology & Carcinogenesis ,Dental/Oral and Craniofacial Disease ,Protein Kinase Inhibitors ,Adjuvant ,Aged ,Cancer ,Tumor ,Radiotherapy ,Squamous Cell Carcinoma of Head and Neck ,DNA ,Genetic Therapy ,Middle Aged ,Combined Modality Therapy ,Xenograft Model Antitumor Assays ,ErbB Receptors ,Orphan Drug ,Head and Neck Neoplasms ,phase 2 ,Public Health and Health Services ,Female ,head and neck cancer ,epidermal growth factor receptor ,Biotechnology - Abstract
BackgroundCetuximab combined with radiation therapy (RT) is an evidence-based treatment for locally advanced head and neck squamous cell carcinoma (HNSCC); however, locoregional failure remains the primary cause of cancer-related death in this disease. Intratumoral injection of epidermal growth factor receptor (EGFR)-antisense plasmid DNA (EGFR-AS) is safe and has been associated with promising lesional responses in patients who have recurrent/metastatic HNSCC. For the current study, the authors investigated the antitumor effects of cetuximab and EGFR-AS in preclinical HNSCC models and reported their phase 1 experience adding intratumoral EGFR-AS to cetuximab RT.MethodsAntitumor mechanisms were investigated in cell line and xenograft models. Phase 1 trial eligibility required stage IVA through IVC HNSCC and a measurable lesion accessible for repeat injections. Patients received standard cetuximab was for 9 weeks. EGFR-AS was injected weekly until they achieved a lesional complete response. RT was delivered by conventional fractionation for 7 weeks, starting at week 3. Research biopsies were obtained at baseline and week 2.ResultsWhen added to cetuximab, EGFR-AS decreased cell viability and xenograft growth compared with EGFR-sense control, partially mediated by reduced EGFR expression. Six patients were enrolled in the phase 1 cohort. No grade 2 or greater EGFR-AS-related adverse events occurred. The best lesional response was a complete response (4 patients), and 1 patient each had a partial response and disease progression. EGFR expression decreased in 4 patients who had available paired specimens.ConclusionsIn preclinical models, dual EGFR inhibition with cetuximab and EGFR-AS enhanced antitumor effects. In a phase 1 cohort, intratumoral EGFR-AS injections, cetuximab, and RT were well tolerated. A phase 2 trial is needed to conduct an extended evaluation of safety and to establish efficacy.
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- 2018
223. Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
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Duvvuri, Umamaheswar, primary, George, Jonathan, additional, Kim, Seungwon, additional, Alvarado, Diego, additional, Neumeister, Veronique M., additional, Chenna, Ahmed, additional, Gedrich, Richard, additional, Hawthorne, Thomas, additional, LaVallee, Theresa, additional, Grandis, Jennifer R., additional, and Bauman, Julie E., additional
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- 2019
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224. Profiling the Stromal and Vascular Heterogeneity in Patient-derived Xenograft Models of Head and Neck Cancer: Impact on Therapeutic Response
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Folaron, Margaret, primary, Merzianu, Mihai, additional, Duvvuri, Umamaheswar, additional, Ferris, Robert L., additional, and Seshadri, Mukund, additional
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- 2019
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225. HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma
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Meister, Kara S., primary, Godse, Neal R., additional, Khan, Nayel I., additional, Hedberg, Matthew L., additional, Kemp, Carolyn, additional, Kulkarni, Sucheta, additional, Alvarado, Diego, additional, LaVallee, Theresa, additional, Kim, Seungwon, additional, Grandis, Jennifer R., additional, and Duvvuri, Umamaheswar, additional
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- 2019
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226. Reconstruction of TORS oropharyngectomy defects with the nasoseptal flap via transpalatal tunnel
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Turner, Meghan T., primary, Geltzeiler, Mathew, additional, Albergotti, W. Greer, additional, Duvvuri, Umamaheswar, additional, Ferris, Robert L., additional, Kim, Seungwon, additional, and Wang, Eric W., additional
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- 2019
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227. Early squamous cell carcinoma of the oral tongue with histologically benign lymph nodes: A model predicting local control and vetting of the eighth edition of the American Joint Committee on Cancer pathologic T stage
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Sridharan, Shaum, primary, Thompson, Lester D. R., additional, Purgina, Bibianna, additional, Sturgis, Charles D., additional, Shah, Akeesha A., additional, Burkey, Brian, additional, Tuluc, Madalina, additional, Cognetti, David, additional, Xu, Bin, additional, Higgins, Kevin, additional, Hernandez‐Prera, Juan C., additional, Guerrero, Dominick, additional, Bundele, Manish M., additional, Kim, Seungwon, additional, Duvvuri, Umamaheswar, additional, Ferris, Robert L., additional, Gooding, William E., additional, and Chiosea, Simion I., additional
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- 2019
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228. Robotic-assisted Base of Tongue Resection for Adult Sleep Apnea
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Turner, Meghan, primary, Moskovitz, Jessica, additional, Mady, Leila, additional, and Duvvuri, Umamaheswar, additional
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- 2019
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229. Variation in the Quality of Head and Neck Cancer Care in the United States
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Strober, William A., primary, Sridharan, Shaum, additional, Duvvuri, Umamaheswar, additional, and Cramer, John D., additional
- Published
- 2019
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230. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer
- Author
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Hedberg, Matthew L., primary, Peyser, Noah D., additional, Bauman, Julie E., additional, Gooding, William E., additional, Li, Hua, additional, Bhola, Neil E., additional, Zhu, Tian Ran, additional, Zeng, Yan, additional, Brand, Toni M., additional, Kim, Mi-Ok, additional, Jordan, Richard C.K., additional, VandenBerg, Scott, additional, Olivas, Victor, additional, Bivona, Trever G., additional, Chiosea, Simion I., additional, Wang, Lin, additional, Mills, Gordon B., additional, Johnson, Jonas T., additional, Duvvuri, Umamaheswar, additional, Ferris, Robert L., additional, Ha, Patrick, additional, Johnson, Daniel E., additional, and Grandis, Jennifer R., additional
- Published
- 2019
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- View/download PDF
231. Primary surgery for human papillomavirus-associated oropharyngeal cancer: Survival outcomes with or without adjuvant treatment
- Author
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Cramer, John D., primary, Ferris, Robert L., additional, Kim, Seungwon, additional, and Duvvuri, Umamaheswar, additional
- Published
- 2018
- Full Text
- View/download PDF
232. Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer.
- Author
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Wang, Zhiyong, Goto, Yusuke, Allevato, Michael M., Wu, Victoria H., Saddawi-Konefka, Robert, Gilardi, Mara, Alvarado, Diego, Yung, Bryan S., O'Farrell, Aoife, Molinolo, Alfredo A., Duvvuri, Umamaheswar, Grandis, Jennifer R., Califano, Joseph A., Cohen, Ezra E. W., and Gutkind, J. Silvio
- Subjects
HEAD & neck cancer ,PROGRAMMED cell death 1 receptors ,IMMUNE checkpoint inhibitors ,CANCER remission ,SQUAMOUS cell carcinoma ,DENDRITIC cells ,ONCOGENES - Abstract
Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but <20% of patients achieve durable responses. Persistent activation of the PI3K/AKT/mTOR signaling circuitry represents a key oncogenic driver in HNSCC; however, the potential immunosuppressive effects of PI3K/AKT/mTOR inhibitors may limit the benefit of their combination with ICB. Here we employ an unbiased kinome-wide siRNA screen to reveal that HER3, is essential for the proliferation of most HNSCC cells that do not harbor PIK3CA mutations. Indeed, we find that persistent tyrosine phosphorylation of HER3 and PI3K recruitment underlies aberrant PI3K/AKT/mTOR signaling in PIK3CA wild type HNSCCs. Remarkably, antibody-mediated HER3 blockade exerts a potent anti-tumor effect by suppressing HER3-PI3K-AKT-mTOR oncogenic signaling and concomitantly reversing the immune suppressive tumor microenvironment. Ultimately, we show that HER3 inhibition and PD-1 blockade may provide a multimodal precision immunotherapeutic approach for PIK3CA wild type HNSCC, aimed at achieving durable cancer remission. There is an unmet need to improve the response to immune checkpoint blockade in patients with head and neck squamous cell carcinoma (HNSCC). Here the authors show that aberrant HER3 activation sustains the proliferation of PIK3CA wild type HNSCC cells and that HER3 inhibition increases response to PD-1 blockade in HNSCC preclinical models. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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- View/download PDF
233. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.
- Author
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Brand, Toni M, Brand, Toni M, Hartmann, Stefan, Bhola, Neil E, Li, Hua, Zeng, Yan, O'Keefe, Rachel A, Ranall, Max V, Bandyopadhyay, Sourav, Soucheray, Margaret, Krogan, Nevan J, Kemp, Carolyn, Duvvuri, Umamaheswar, LaVallee, Theresa, Johnson, Daniel E, Ozbun, Michelle A, Bauman, Julie E, Grandis, Jennifer R, Brand, Toni M, Brand, Toni M, Hartmann, Stefan, Bhola, Neil E, Li, Hua, Zeng, Yan, O'Keefe, Rachel A, Ranall, Max V, Bandyopadhyay, Sourav, Soucheray, Margaret, Krogan, Nevan J, Kemp, Carolyn, Duvvuri, Umamaheswar, LaVallee, Theresa, Johnson, Daniel E, Ozbun, Michelle A, Bauman, Julie E, and Grandis, Jennifer R
- Abstract
Human papillomavirus (HPV) type 16 is implicated in approximately 75% of head and neck squamous cell carcinomas (HNSCC) that arise in the oropharynx, where viral expression of the E6 and E7 oncoproteins promote cellular transformation, tumor growth, and maintenance. An important oncogenic signaling pathway activated by E6 and E7 is the PI3K pathway, a key driver of carcinogenesis. The PI3K pathway is also activated by mutation or amplification of PIK3CA in over half of HPV(+) HNSCC. In this study, we investigated the efficacy of PI3K-targeted therapies in HPV(+) HNSCC preclinical models and report that HPV(+) cell line- and patient-derived xenografts are resistant to PI3K inhibitors due to feedback signaling emanating from E6 and E7. Receptor tyrosine kinase profiling indicated that PI3K inhibition led to elevated expression of the HER3 receptor, which in turn increased the abundance of E6 and E7 to promote PI3K inhibitor resistance. Targeting HER3 with siRNA or the mAb CDX-3379 reduced E6 and E7 abundance and enhanced the efficacy of PI3K-targeted therapies. Together, these findings suggest that cross-talk between HER3 and HPV oncoproteins promotes resistance to PI3K inhibitors and that cotargeting HER3 and PI3K may be an effective therapeutic strategy in HPV(+) tumors.Significance: These findings suggest a new therapeutic combination that may improve outcomes in HPV(+) head and neck cancer patients. Cancer Res; 78(9); 2383-95. ©2018 AACR.
- Published
- 2018
234. Robot-assisted neck dissection.
- Author
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Godse, Neal Rajan and Duvvuri, Umamaheswar
- Abstract
The neck dissection is an integral component of comprehensive oncologic care for patients with head and neck cancer. Modern robotic surgical platforms are being utilized within otolaryngology for a growing number of indications, including, robot-assisted neck dissections. The proposed benefits of robot-assisted include improved cosmesis and reductions in post-operative lymphedema. Early data suggests that oncologic control following robot-assisted neck dissection is comparable to the gold-standard, open technique. Here we present review of the surgical techniques involved in a robot-assisted neck dissection as well as a review of perioperative care. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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- View/download PDF
235. Quality and Readability Assessment of Websites on Human Papillomavirus and Oropharyngeal Cancer.
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Schwarzbach, Hannah L., Mady, Leila J., Kaffenberger, Thomas M., Duvvuri, Umamaheswar, and Jabbour, Noel
- Abstract
Objectives/hypothesis: The incidence of human papillomavirus-positive (HPV+) oropharyngeal cancer is rising, but public knowledge about this diagnosis remains low. This study aimed to investigate the quality and readability of online information about HPV+ oropharyngeal cancer.Study Design: Cross-sectional website analysis.Methods: This study conducted a total of 12 web searches across Google, Yahoo, and Bing to identify websites related to HPV+ oropharyngeal cancer. The QUality Evaluation Scoring Tool (QUEST) was used to measure quality based on seven website criteria. The Flesch Reading Ease Score (FRES) and Flesch-Kincaid Grade Level (FKGL) were used to measure readability, with scores estimating the education level a reader would require to understand a piece of text. Readability improves as FRES increases and FKGL decreases.Results: Twenty-seven unique web pages were evaluated. The mean USA reading grade level as measured by FKGL was 10.42 (standard deviation = 1.54). There was an inverse relationship between quality and readability, with a significant positive correlation between QUEST score and FKGL (r = 0.343, P = .040) and a significant negative correlation between QUEST score and FRES (r = -0.537, P = .002).Conclusions: With a mean USA reading grade level more than four grades above the American Medical Association's recommendation and results indicating that readability suffers as quality improves, these findings suggest that the currently available online information about HPV+ oropharyngeal cancer is insufficient. Improved patient education practices and resources about this diagnosis are needed.Level Of Evidence: NA Laryngoscope, 131:87-94, 2021. [ABSTRACT FROM AUTHOR]- Published
- 2021
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236. Transcervical arterial ligation for prevention of postoperative hemorrhage in transoral oropharyngectomy: Systematic review and meta‐analysis.
- Author
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Sharbel, Daniel D., Abkemeier, Mary, Sullivan, James, Zimmerman, Zach, Albergotti, William G., Duvvuri, Umamaheswar, and Byrd, James Kenneth
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HEMORRHAGE ,SURGICAL robots ,TUMOR classification ,ODDS ratio ,ENGLISH literature ,CHEMOEMBOLIZATION - Abstract
Background: Transcervical arterial ligation has been studied as a useful procedure to prevent bleeding events after transoral robotic surgery (TORS). Methods: A systematic review of English‐language literature on arterial ligation in TORS from 2005 to 2019 was conducted using Cochrane, PubMed, Web of Science (WoS), and ScienceDirect databases. Studies evaluating ligation and rates of postoperative hemorrhage were included. Meta‐analysis of included studies was performed to assess impact of ligation on postoperative hemorrhage. Results: Five studies with 2008 patients were included. History of radiation (odds ratio [OR] = 2.26, P =.02) and advanced tumor stage (OR = 1.93, P =.02) were found to predispose patients to postoperative hemorrhage. Arterial ligation was protective against severe hemorrhage in the mixed primary surgical modality cohort (OR = 0.33, P =.03) and in the TORS‐only subgroup (OR = 0.21, P =.02), but did not significantly impact overall odds of postoperative hemorrhage. Conclusion: Transcervical arterial ligation offers protection against major/severe postoperative hemorrhage in patients undergoing TORS. Level of Evidence: II. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
237. Effect of transcervical arterial ligation on the severity of postoperative hemorrhage after transoral robotic surgery
- Author
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Kubik, Mark, Mandal, Rajarsi, Albergotti, William, Duvvuri, Umamaheswar, Ferris, Robert L., and Kim, Seungwon
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Male ,Arteries ,Middle Aged ,Postoperative Hemorrhage ,Severity of Illness Index ,Article ,Oropharyngeal Neoplasms ,Robotic Surgical Procedures ,Risk Factors ,Humans ,Female ,Ligation ,Neck ,Retrospective Studies - Abstract
The value of transcervical arterial ligation during transoral robotic surgery (TORS) as a measure to decrease postoperative bleeding incidence or severity is unclear.A retrospective single institution study was performed to identify risk factors for hemorrhage after TORS for oropharyngeal squamous cell carcinoma (SCC).Overall, 13.2% of patients (35/265) experience postoperative hemorrhage. T classification, perioperative use of anticoagulants, surgeon experience50 cases, and tumor subsite were not predictors of postoperative hemorrhage. Of this cohort, 28% underwent prophylactic arterial ligation. The overall incidence of bleeding was not significantly decreased in patients who underwent arterial ligation (12.1% vs 13.6%; p = .84). However, arterial ligation significantly reduced the incidence of major and severe bleeding events (1.3% vs 7.8%; p = .04). Radiation before TORS was a risk factor for major and severe postoperative hemorrhage (p.02).Transcervical arterial ligation during TORS may reduce the severity of postoperative hemorrhagic events. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1510-1515, 2017.
- Published
- 2017
238. TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2
- Author
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Kulkarni, Sucheta, Bill, Anke, Godse, Neal R, Khan, Nayel I, Kass, Jason I, Steehler, Kevin, Kemp, Carolyn, Davis, Kara, Bertrand, Carol A, Vyas, Avani R, Holt, Douglas E, Grandis, Jennifer R, Gaither, L Alex, and Duvvuri, Umamaheswar
- Subjects
Nude ,Oncology and Carcinogenesis ,Cetuximab ,Breast Neoplasms ,Chromosomes ,Cell Line ,Mice ,ErbB-2 ,Rare Diseases ,Chloride Channels ,Breast Cancer ,Animals ,Humans ,2.1 Biological and endogenous factors ,Oncology & Carcinogenesis ,Pair 11 ,Aetiology ,Anoctamin-1 ,Cancer ,Tumor ,Squamous Cell Carcinoma of Head and Neck ,Carcinoma ,Trastuzumab ,Neoplasm Proteins ,ErbB Receptors ,Squamous Cell ,Head and Neck Neoplasms ,Female ,Human ,Receptor ,Biotechnology - Abstract
TMEM16A, a Ca2+ -activated Cl- channel, contributes to tumor growth in breast cancer and head and neck squamous cell carcinoma (HNSCC). Here, we investigated whether TMEM16A influences the response to EGFR/HER family-targeting biological therapies. Inhibition of TMEM16A Cl- channel activity in breast cancer cells with HER2 amplification induced a loss of viability. Cells resistant to trastuzumab, a monoclonal antibody targeting HER2, showed an increase in TMEM16A expression and heightened sensitivity to Cl- channel inhibition. Treatment of HNSCC cells with cetuximab, a monoclonal antibody targeting EGFR, and simultaneous TMEM16A suppression led to a pronounced loss of viability. Biochemical analyses of cells subjected to TMEM16A inhibitors or expressing chloride-deficient forms of TMEM16A provide further evidence that TMEM16A channel function may play a role in regulating EGFR/HER2 signaling. These data demonstrate that TMEM16A regulates EGFR and HER2 in growth and survival pathways. Furthermore, in the absence of TMEM16A cotargeting, tumor cells may acquire resistance to EGFR/HER inhibitors. Finally, targeting TMEM16A improves response to biological therapies targeting EGFR/HER family members.
- Published
- 2017
239. A prospective evaluation of short-term dysphagia after transoral robotic surgery for squamous cell carcinoma of the oropharynx
- Author
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Albergotti, William G., Jordan, Jessica, Anthony, Keely, Abberbock, Shira, Wasserman-Wincko, Tamara, Kim, Seungwon, Ferris, Robert L., and Duvvuri, Umamaheswar
- Subjects
Adult ,Male ,Natural Orifice Endoscopic Surgery ,Time Factors ,Squamous Cell Carcinoma of Head and Neck ,Middle Aged ,Article ,Otorhinolaryngologic Surgical Procedures ,Oropharyngeal Neoplasms ,Postoperative Complications ,Robotic Surgical Procedures ,Head and Neck Neoplasms ,Carcinoma, Squamous Cell ,Humans ,Female ,Prospective Studies ,Deglutition Disorders ,Aged ,Neoplasm Staging - Abstract
Transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) has been associated with improved long-term dysphagia symptomatology compared with chemoradiation. Dysphagia in the perioperative period has been inadequately characterized. The objective of this study was to characterize short-term swallowing outcomes after TORS for OPSCC.Patients undergoing TORS for OPSCC were enrolled prospectively. The Eating Assessment Tool 10 (EAT-10) was used as a measure of swallowing dysfunction (score2) and was administered on postoperative day (POD) 1, 7, and 30. Patient demographics, weight, pain level, and clinical outcomes were recorded prospectively and focused on time to oral diet, feeding tube placement, and dysphagia-related readmissions.A total of 51 patients were included with pathologic T stages of T1 (n = 24), T2 (n = 20), T3 (n = 3), and Tx (n = 4). Self-reported preoperative dysphagia was unusual (13.7%). The mean EAT-10 score on POD 1 was lower than on POD 7 (21.5 vs 26.6; P = .005) but decreased by POD 30 (26.1 to 12.2; P.001). Forty-seven (92.1%) patients were discharged on an oral diet, but 57.4% required compensatory strategies or modification of liquid consistency. Ninety-eight percent of patients were taking an oral diet by POD 30. There were no dysphagia-related readmissions.This prospective study shows that most patients who undergo TORS experience dysphagia for at least the first month postoperatively, but nearly all can be started on an oral diet. The dysphagia-associated complication profile is acceptable after TORS with a minority of patients requiring temporary feeding tube placement. Aggressive evaluation and management of postoperative dysphagia in TORS patients may help prevent dysphagia-associated readmissions. Cancer 2017;123:3132-40. © 2017 American Cancer Society.
- Published
- 2016
240. 17O-Decoupled 1H Spectroscopy and Imaging with a Surface Coil: STEAM Decoupling
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Charagundla, Sridhar R, Duvvuri, Umamaheswar, Noyszewski, Elizabeth A, Dandora, Rahul, Stolpen, Alan H, Leigh, J.S, and Reddy, Ravinder
- Published
- 2000
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241. Molecular Profile of Locally Aggressive Well Differentiated Thyroid Cancers.
- Author
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Mady, Leila J., Grimes, Michael C., Khan, Nayel I., Rao, R. Harsha, Chiosea, Simion I., Yip, Linwah, Ferris, Robert L., Nikiforov, Yuri E., Carty, Sally E., and Duvvuri, Umamaheswar
- Subjects
THYROID cancer ,NUCLEOTIDE sequencing ,SURVIVAL analysis (Biometry) ,KAPLAN-Meier estimator ,THYROID cancer treatment - Abstract
Knowledge of the genetic landscape of aggressive well differentiated thyroid cancers (WDTC) is lacking. Retrospective review of institutional database was performed to identify locally-invasive thyroid carcinomas and a comparison cohort of low-risk WDTC. ThyroSeq v2 next-generation sequencing was performed on available tissue. Survival time was analyzed by Kaplan-Meier methods and compared between groups via the log-rank test. Time to recurrence, treating death as a competing risk, was analyzed by cumulative incidence and compared between groups. Of 80 T4 tumors, 29 (36%) were met inclusion criteria, of which, 25 had genetic and clinicopathologic data. Most (24/25, 96%) harbored at least one genetic alteration, most commonly BRAF V600E (19, 76%), followed by mutations in the promoter region of TERT (14, 56%). Co-occurrence of BRAF and TERT was identified in 12 (48%) and associated with significantly higher risk of recurrence (p < 0.05). Conversely, co-occurrence of BRAF and TERT was present in only 5 of 102 (5%) patients presenting with early-stage WDTC. Compared to early-stage WDTC, co-occurrence of BRAF and TERT mutations are common in locally advanced (T4) thyroid cancer and are associated with an increased risk of recurrence. This knowledge may help predict aggressive behavior pretreatment and inform perioperative decision-making. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
242. Reconstruction of TORS oropharyngectomy defects with the nasoseptal flap via transpalatal tunnel.
- Author
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Turner, Meghan T., Geltzeiler, Mathew, Albergotti, W. Greer, Duvvuri, Umamaheswar, Ferris, Robert L., Kim, Seungwon, and Wang, Eric W.
- Abstract
The nasoseptal flap (NSF) has been described as reconstructive option for soft palate defects following transoral robotic surgery (TORS). As described, this technique is does not provide adequate coverage of the lateral oropharyngeal wall, parapharyngeal space, exposed vessels, or exposed mandibular bone. The NSF for TORS reconstruction has been limited to soft palate reconstruction, given the limitations on length when passed via the nasopharynx. In this article, we describe (1) a novel technique for TORS reconstruction using direct transposition of the ipsilateral NSF into the oropharynx via a transpalatal tunnel at the hard–soft palate junction, and (2) its use in select patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
243. Transoral surgery using the Flex Robotic System: Initial experience in the United States
- Author
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Persky, Michael J., primary, Issa, Mohamad, additional, Bonfili, Jennifer R., additional, Goyal, Neerav, additional, Goldenberg, David, additional, and Duvvuri, Umamaheswar, additional
- Published
- 2018
- Full Text
- View/download PDF
244. Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Stage I to II Oral Cavity Cancer
- Author
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Cramer, John D., primary, Sridharan, Shaum, additional, Ferris, Robert L., additional, Duvvuri, Umamaheswar, additional, and Samant, Sandeep, additional
- Published
- 2018
- Full Text
- View/download PDF
245. Phase 1 study of EGFR-antisense DNA, cetuximab, and radiotherapy in head and neck cancer with preclinical correlatives
- Author
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Bauman, Julie E., primary, Duvvuri, Umamaheswar, additional, Thomas, Sufi, additional, Gooding, William E., additional, Clump, David A., additional, Karlovits, Brian, additional, Wehbe, Ahmad, additional, Miller, Frank R., additional, Kim, Seungwon, additional, Sen, Malabika, additional, Heron, Dwight E., additional, Grandis, Jennifer R., additional, and Argiris, Athanassios, additional
- Published
- 2018
- Full Text
- View/download PDF
246. Concurrent Chemoradiotherapy in the Adjuvant Treatment of High-risk Primary Salivary Gland Malignancies
- Author
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Gebhardt, Brian J., primary, Ohr, James P., additional, Ferris, Robert L., additional, Duvvuri, Umamaheswar, additional, Kim, Seungwon, additional, Johnson, Jonas T., additional, Heron, Dwight E., additional, and Clump, David A., additional
- Published
- 2018
- Full Text
- View/download PDF
247. Staging HPV-related oropharyngeal cancer: Validation of AJCC-8 in a surgical cohort
- Author
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Geltzeiler, Mathew, primary, Bertolet, Marnie, additional, Albergotti, William, additional, Gleysteen, John, additional, Olson, Brennan, additional, Persky, Michael, additional, Gross, Neil, additional, Li, Ryan, additional, Andersen, Peter, additional, Kim, Seungwon, additional, Ferris, Robert L., additional, Duvvuri, Umamaheswar, additional, and Clayburgh, Daniel, additional
- Published
- 2018
- Full Text
- View/download PDF
248. The mutational landscape of recurrent versus nonrecurrent human papillomavirus–related oropharyngeal cancer
- Author
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Harbison, R. Alex, primary, Kubik, Mark, additional, Konnick, Eric Q., additional, Zhang, Qing, additional, Lee, Seok-Geun, additional, Park, Heuijoon, additional, Zhang, Jianan, additional, Carlson, Christopher S., additional, Chen, Chu, additional, Schwartz, Stephen M., additional, Rodriguez, Cristina P., additional, Duvvuri, Umamaheswar, additional, and Méndez, Eduardo, additional
- Published
- 2018
- Full Text
- View/download PDF
249. Abstract CT135: A pre-surgical window of opportunity study to investigate the biomarker effects of DNA damage response (DDR) agents in patients (pts) with head and neck squamous cell carcinoma (HNSCC)
- Author
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Duvvuri, Umamaheswar, primary, Dean, Emma, additional, Frewer, Paul, additional, Berges, Alienor, additional, Cheung, S. Y., additional, Stephens, Christine, additional, Khan, Musaddiq, additional, Hollingsworth, Simon J., additional, and Pierce, Andrew J., additional
- Published
- 2018
- Full Text
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250. Abstract CT058: Molecular and clinical activity of CDX-3379, an anti-ErbB3 monoclonal antibody, in head and neck squamous cell carcinoma: A preoperative "window of opportunity" study
- Author
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Duvvuri, Umamaheswar, primary, George, Jonathan, additional, Kim, Seungwon, additional, Alvarado, Diego, additional, Neumeister, Veronique, additional, Chenna, Ahmed, additional, Hawthorne, Thomas, additional, LaVallee, Theresa, additional, Grandis, Jennifer R., additional, and Bauman, Julie E., additional
- Published
- 2018
- Full Text
- View/download PDF
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