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884 results on '"Duijn, C. M."'

201. Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

Author

Schelleman, H, Klungel, O H, van Duijn, C M, Witteman, J C M, Hofman, A, de Boer, A, Stricker, B H Ch, Schelleman, H, Klungel, O H, van Duijn, C M, Witteman, J C M, Hofman, A, de Boer, A, and Stricker, B H Ch

Abstract

AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

Published
2005

202. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease

Author

Rademakers, R, Sleegers, K, Theuns, J, Van den Broeck, M, Kacem, S B, Nilsson, L G, Adolfsson, Rolf, van Duijn, C M, Van Broeckhoven, C, Cruts, M, Rademakers, R, Sleegers, K, Theuns, J, Van den Broeck, M, Kacem, S B, Nilsson, L G, Adolfsson, Rolf, van Duijn, C M, Van Broeckhoven, C, and Cruts, M

Abstract

Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding CDK5 (CDK5), p35 (CDK5RI) and p39 (CDK5R2), we excluded causal mutations in 70 familial early-onset AD patients. We performed an association study with five informative SNPs in CDK5 in two independent samples of early-onset AD patients and matched control individuals from The Netherlands and northern Sweden. Association was observed with g.149800G > C in intron 5 of CDK5, and a two times increased risk was observed in both patient samples for carriers of the C-allele. Our data are indicative for a role of the CDK5 molecular complex in the genetic etiology of early-onset AD, and suggest that a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset AD.

Published
2005
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203. Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors

Author

Dep Farmaceutische wetenschappen, Sub Pharmacotherapy, Theoretical, Schelleman, H, Klungel, O H, van Duijn, C M, Witteman, J C M, Hofman, A, de Boer, A, Stricker, B H Ch, Dep Farmaceutische wetenschappen, Sub Pharmacotherapy, Theoretical, Schelleman, H, Klungel, O H, van Duijn, C M, Witteman, J C M, Hofman, A, de Boer, A, and Stricker, B H Ch

Published
2005

204. Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth

Author

Parmar, P. G., primary, Marsh, J. A., additional, Rob Taal, H., additional, Kowgier, M., additional, Uitterlinden, A. G., additional, Rivadeneira, F., additional, Briollais, L., additional, Newnham, J. P., additional, Hofman, A., additional, Lye, S. J., additional, Steegers, E. A. P., additional, van Duijn, C. M., additional, Palmer, L. J., additional, Jaddoe, V. W. V., additional, and Pennell, C. E., additional

Published
2012
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205. Association of heat shock proteins with all-cause mortality

Author

Broer, L., primary, Demerath, E. W., additional, Garcia, M. E., additional, Homuth, G., additional, Kaplan, R. C., additional, Lunetta, K. L., additional, Tanaka, T., additional, Tranah, G. J., additional, Walter, S., additional, Arnold, A. M., additional, Atzmon, G., additional, Harris, T. B., additional, Hoffmann, W., additional, Karasik, D., additional, Kiel, D. P., additional, Kocher, T., additional, Launer, L. J., additional, Lohman, K. K., additional, Rotter, J. I., additional, Tiemeier, H., additional, Uitterlinden, A. G., additional, Wallaschofski, H., additional, Bandinelli, S., additional, Dörr, M., additional, Ferrucci, L., additional, Franceschini, N., additional, Gudnason, V., additional, Hofman, A., additional, Liu, Y., additional, Murabito, J. M., additional, Newman, A. B., additional, Oostra, B. A., additional, Psaty, B. M., additional, Smith, A. V., additional, and van Duijn, C. M., additional

Published
2012
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206. Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies.

Author

Pocchiari, M, Puopolo, M, Croes, E A, Budka, H, Gelpi, E, Collins, S, Lewis, V, Sutcliffe, T, Guilivi, A, Delasnerie-Laupretre, N, Brandel, J-P, Alperovitch, A, Zerr, I, Poser, S, Kretzschmar, H A, Ladogana, A, Rietvald, I, Mitrova, E, Martinez-Martin, P, de Pedro-Cuesta, J, Glatzel, M, Aguzzi, A; https://orcid.org/0000-0002-0344-6708, Cooper, S, Mackenzie, J, van Duijn, C M, Will, R G, Pocchiari, M, Puopolo, M, Croes, E A, Budka, H, Gelpi, E, Collins, S, Lewis, V, Sutcliffe, T, Guilivi, A, Delasnerie-Laupretre, N, Brandel, J-P, Alperovitch, A, Zerr, I, Poser, S, Kretzschmar, H A, Ladogana, A, Rietvald, I, Mitrova, E, Martinez-Martin, P, de Pedro-Cuesta, J, Glatzel, M, Aguzzi, A; https://orcid.org/0000-0002-0344-6708, Cooper, S, Mackenzie, J, van Duijn, C M, and Will, R G

Abstract

A collaborative study of human transmissible spongiform encephalopathies has been carried out from 1993 to 2000 and includes data from 10 national registries, the majority in Western Europe. In this study, we present analyses of predictors of survival in sporadic (n = 2304), iatrogenic (n = 106) and variant Creutzfeldt-Jakob disease (n = 86) and in cases associated with mutations of the prion protein gene (n = 278), including Gerstmann-Sträussler-Scheinker syndrome (n = 24) and fatal familial insomnia (n = 41). Overall survival for each disease type was assessed by the Kaplan-Meier method and the multivariate analyses by the Cox proportional hazards model. In sporadic disease, longer survival was correlated with younger age at onset of illness, female gender, codon 129 heterozygosity, presence of CSF 14-3-3 protein and type 2a prion protein type. The ability to predict survival based on patient covariates is important for diagnosis and counselling, and the characterization of the survival distributions, in the absence of therapy, will be an important starting point for the assessment of potential therapeutic agents in the future.

Published
2004

207. RISICOFACTOREN VOOR HART- EN VAATZIEKTEN BIJ OUDEREN; HET ERGO-ONDERZOEK

Author

Mennen, L. I., Witteman, J. C.M., Geleijnse, J. M., Stolk, R. P., Visser, M. C., Grobbee, D. E., Van Der Bom, J. G., Bots, M. L., Den Breeijen, J. H., Breteler, M. M.B., De Bruijn, A. M., De Bruyne, M. C., Burger, H., Claus, J. J., Van Daele, P. L.A., Dielemans, I., Van Duijn, C. M., Hoes, A. W., and Hofman, A.

Abstract

Objective. To determine the prevalence of risk factors for cardiovascular disease among elderly people. Design. Prospective cohort study. Setting. A district of Rotterdam, the Netherlands. Methods. As a part of the Rotterdam Study information about smoking habits, blood pressure, Quetelet index and serum cholesterol of 7,983 responding persons (78%) (3,105 men and 4,878 women) of 55 years and older was obtained by an interview and physical examination during two visits to a research center. Results. Among men and women there were 29.7% and 16.7% smokers and 60.1% and 25.9% ex-smokers, respectively. Among men the proportion of smokers decreased from 31.0% in the age category 55-59 years to 15.9% in the category ≥85 years, among women from 28.0% to 2.7% . Systolic blood pressure increased with age in both sexes, while diastolic blood pressure hardly changed. Hypertension (systolic blood pressure 160 mmHg and/or diastolic blood pressure ≥95 mmHg at a single measurement and/or use of antihypertensive drugs) occurred in 23.3% of men and 28.0% of women. In men, total serum cholesterol decreased gradually with age, whereas in women there was a slight increase up to the category 70-74 years. No evident change in HDL cholesterol with increasing age was observed in men, but in women a decrease was observed until the same level was reached as in men. Thirty-five per cent of men and 49.5% of women had an elevated level of serum cholesterol (≥6,5 mmol/l). The prevalence of obesity (Quetelet index > 25 kg/m2) was about 50% in both men and women but was less in the categories from 75 years onwards. Approximately 80% of men and women had at least one risk factor, while in almost half of them two or more risk factors were found. Conclusion. Risk factors for cardiovascular disease are common among elderly people.

Published
1995

208. A case-control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome. Dutch Study Group on Down's Syndrome and Ageing

Author

van Gool, W. A., Evenhuis, H. M., van Duijn, C. M., and Other departments

Abstract

The prevalence of clinical signs and neuropathological findings of Alzheimer's disease (AD) is high in Down's syndrome (DS). In the general population, the apolipoprotein E (ApoE) epsilon 4 isoform is an important risk for AD. We studied the allelic frequencies of ApoE in 26 DS cases fulfilling clinical diagnostic criteria for AD and in 26 DS controls matched for age, sex, and premorbid level of mental retardation. A meta-analysis of data available in the literature was used for comparison with allele frequencies in other AD and control populations. ApoE type 2, 3, or 4 allele frequencies were not significantly different in AD-DS cases and DS controls. The ApoE epsilon 4 frequency in DS cases with AD (0.14; CI, 0.06-0.26) was significantly lower than in any other AD population studied so far and it is within the range of nondemented controls from the general population. These findings suggest that ApoE epsilon 4 does not significantly affect the pathogenesis of AD in DS patients

Published
1995

209. Cardiovascular disease among elderly people; the 'Rotterdam elderly study'

Author

Grobbee, D. E., Van Der Bom, J. G., Bots, M. L., De Bruijne, M. C., Mosterd, A., Hoes, A. W., Den Breeijen, J. H., Breteler, M. M.B., De Bruijn, A. M., Burger, H., Claus, J. J., Van Daele, P. L.A., Dielemans, I., Van Duijn, C. M., Geleijnse, J. M., Hofman, A., De Jong, P. T.V.M., Klaver, C. C.W., De Laet, C. E.D.H., Public and occupational health, APH - Methodology, and APH - Quality of Care

Abstract

Objective. To determine the prevalence of cardiovascular disease among elderly people and to investigate the use of cardiovascular medication in this group. Design. Cross-sectional study. Setting. A quarter in Rotterdam, the Netherlands. Methods. As a part of the 'Rotterdam elderly study', the cardiovascular anamnesis of 7,983 responding persons ≥55 years (3105 men and 4878 women) was obtained by means of a questionnaire. Results. Twelve and 4% of men and women, respectively, had at some time had a myocardial infarction, and 5 and 4% a stroke. Almost 7% of both sexes had anamnestic symptoms of angina pectoris. Coronary bypass surgery and percutaneous transluminal coronary angioplasty were done in 4% and 1% of men and 1% and 0,5% of women, respectively. Of all participants 43% used at least one drug for cardiovascular purposes. Half of these used two or more, and a quarter used three or more drugs. Among women, diuretics were the most commonly used drug for cardiovascular purposes (21%), whereas among men beta-blocking agents were most common (15%). Conclusion. Cardiovascular diseases are common among elderly men and women. Many of them take at least one drug for cardiovascular purposes.

Published
1995

210. Exome-sequencing in a large population-based study reveals a rare Asn396Servariant in the LIPGgene associated with depressive symptoms

Author

Amin, N, Jovanova, O, Adams, H H H, Dehghan, A, Kavousi, M, Vernooij, M W, Peeters, R P, de Vrij, F M S, van der Lee, S J, van Rooij, J G J, van Leeuwen, E M, Chaker, L, Demirkan, A, Hofman, A, Brouwer, R W W, Kraaij, R, Willems van Dijk, K, Hankemeier, T, van Ijcken, W F J, Uitterlinden, A G, Niessen, W J, Franco, O H, Kushner, S A, Ikram, M A, Tiemeier, H, and van Duijn, C M

Abstract

Despite a substantial genetic component, efforts to identify common genetic variation underlying depression have largely been unsuccessful. In the current study we aimed to identify rare genetic variants that might have large effects on depression in the general population. Using high-coverage exome-sequencing, we studied the exonic variants in 1265 individuals from the Rotterdam study (RS), who were assessed for depressive symptoms. We identified a missense Asn396Sermutation (rs77960347) in the endothelial lipase (LIPG) gene, occurring with an allele frequency of 1% in the general population, which was significantly associated with depressive symptoms (P-value=5.2 × 10−08, β=7.2). Replication in three independent data sets (N=3612) confirmed the association of Asn396Ser(P-value=7.1 × 10−03, β=2.55) with depressive symptoms. LIPGis predicted to have enzymatic function in steroid biosynthesis, cholesterol biosynthesis and thyroid hormone metabolic processes. The Asn396Servariant is predicted to have a damaging effect on the function of LIPG. Within the discovery population, carriers also showed an increased burden of white matter lesions (P-value=3.3 × 1−02) and a higher risk of Alzheimer’s disease (odds ration=2.01; P-value=2.8 × 10−02) compared with the non-carriers. Together, these findings implicate the Asn396Servariant of LIPGin the pathogenesis of depressive symptoms in the general population.

Published
2017
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211. A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila

Author

Allebrandt, K V, primary, Amin, N, additional, Müller-Myhsok, B, additional, Esko, T, additional, Teder-Laving, M, additional, Azevedo, R V D M, additional, Hayward, C, additional, van Mill, J, additional, Vogelzangs, N, additional, Green, E W, additional, Melville, S A, additional, Lichtner, P, additional, Wichmann, H-E, additional, Oostra, B A, additional, Janssens, A C J W, additional, Campbell, H, additional, Wilson, J F, additional, Hicks, A A, additional, Pramstaller, P P, additional, Dogas, Z, additional, Rudan, I, additional, Merrow, M, additional, Penninx, B, additional, Kyriacou, C P, additional, Metspalu, A, additional, van Duijn, C M, additional, Meitinger, T, additional, and Roenneberg, T, additional

Published
2011
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212. Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking

Author

Terracciano, A, primary, Esko, T, additional, Sutin, A R, additional, de Moor, M H M, additional, Meirelles, O, additional, Zhu, G, additional, Tanaka, T, additional, Giegling, I, additional, Nutile, T, additional, Realo, A, additional, Allik, J, additional, Hansell, N K, additional, Wright, M J, additional, Montgomery, G W, additional, Willemsen, G, additional, Hottenga, J-J, additional, Friedl, M, additional, Ruggiero, D, additional, Sorice, R, additional, Sanna, S, additional, Cannas, A, additional, Räikkönen, K, additional, Widen, E, additional, Palotie, A, additional, Eriksson, J G, additional, Cucca, F, additional, Krueger, R F, additional, Lahti, J, additional, Luciano, M, additional, Smoller, J W, additional, van Duijn, C M, additional, Abecasis, G R, additional, Boomsma, D I, additional, Ciullo, M, additional, Costa, P T, additional, Ferrucci, L, additional, Martin, N G, additional, Metspalu, A, additional, Rujescu, D, additional, Schlessinger, D, additional, and Uda, M, additional

Published
2011
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213. The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

Author

Middeldorp, C M, primary, de Moor, M H M, additional, McGrath, L M, additional, Gordon, S D, additional, Blackwood, D H, additional, Costa, P T, additional, Terracciano, A, additional, Krueger, R F, additional, de Geus, E J C, additional, Nyholt, D R, additional, Tanaka, T, additional, Esko, T, additional, Madden, P A F, additional, Derringer, J, additional, Amin, N, additional, Willemsen, G, additional, Hottenga, J-J, additional, Distel, M A, additional, Uda, M, additional, Sanna, S, additional, Spinhoven, P, additional, Hartman, C A, additional, Ripke, S, additional, Sullivan, P F, additional, Realo, A, additional, Allik, J, additional, Heath, A C, additional, Pergadia, M L, additional, Agrawal, A, additional, Lin, P, additional, Grucza, R A, additional, Widen, E, additional, Cousminer, D L, additional, Eriksson, J G, additional, Palotie, A, additional, Barnett, J H, additional, Lee, P H, additional, Luciano, M, additional, Tenesa, A, additional, Davies, G, additional, Lopez, L M, additional, Hansell, N K, additional, Medland, S E, additional, Ferrucci, L, additional, Schlessinger, D, additional, Montgomery, G W, additional, Wright, M J, additional, Aulchenko, Y S, additional, Janssens, A C J W, additional, Oostra, B A, additional, Metspalu, A, additional, Abecasis, G R, additional, Deary, I J, additional, Räikkönen, K, additional, Bierut, L J, additional, Martin, N G, additional, Wray, N R, additional, van Duijn, C M, additional, Smoller, J W, additional, Penninx, B W J H, additional, and Boomsma, D I, additional

Published
2011
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214. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

Author

Grallert, H., primary, Dupuis, J., additional, Bis, J. C., additional, Dehghan, A., additional, Barbalic, M., additional, Baumert, J., additional, Lu, C., additional, Smith, N. L., additional, Uitterlinden, A. G., additional, Roberts, R., additional, Khuseyinova, N., additional, Schnabel, R. B., additional, Rice, K. M., additional, Rivadeneira, F., additional, Hoogeveen, R. C., additional, Fontes, J. D., additional, Meisinger, C., additional, Keaney, J. F., additional, Lemaitre, R., additional, Aulchenko, Y. S., additional, Vasan, R. S., additional, Ellis, S., additional, Hazen, S. L., additional, van Duijn, C. M., additional, Nelson, J. J., additional, Marz, W., additional, Schunkert, H., additional, McPherson, R. M., additional, Stirnadel-Farrant, H. A., additional, Psaty, B. M., additional, Gieger, C., additional, Siscovick, D., additional, Hofman, A., additional, Illig, T., additional, Cushman, M., additional, Yamamoto, J. F., additional, Rotter, J. I., additional, Larson, M. G., additional, Stewart, A. F. R., additional, Boerwinkle, E., additional, Witteman, J. C. M., additional, Tracy, R. P., additional, Koenig, W., additional, Benjamin, E. J., additional, and Ballantyne, C. M., additional

Published
2011
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216. DNA REPAIR CAPACITY DETERMINES AGE-RELATED VASCULAR DYSFUNCTION

Author

Durik, M., primary, Kavousi, M., additional, van der Pluijm, I., additional, Isaacs, A., additional, Ridwan, R. Y., additional, Brandt, R., additional, Loot, A., additional, Flemming, I., additional, Duijn, C. M., additional, Witteman, J. C. M., additional, Hoeijmakers, J., additional, Danser, A. H. J., additional, Duncker, D. J., additional, and Roks, A. J. M., additional

Published
2011
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217. Meta-analysis of genome-wide association studies for personality

Author

de Moor, M H M, primary, Costa, P T, additional, Terracciano, A, additional, Krueger, R F, additional, de Geus, E J C, additional, Toshiko, T, additional, Penninx, B W J H, additional, Esko, T, additional, Madden, P A F, additional, Derringer, J, additional, Amin, N, additional, Willemsen, G, additional, Hottenga, J-J, additional, Distel, M A, additional, Uda, M, additional, Sanna, S, additional, Spinhoven, P, additional, Hartman, C A, additional, Sullivan, P, additional, Realo, A, additional, Allik, J, additional, Heath, A C, additional, Pergadia, M L, additional, Agrawal, A, additional, Lin, P, additional, Grucza, R, additional, Nutile, T, additional, Ciullo, M, additional, Rujescu, D, additional, Giegling, I, additional, Konte, B, additional, Widen, E, additional, Cousminer, D L, additional, Eriksson, J G, additional, Palotie, A, additional, Peltonen, L, additional, Luciano, M, additional, Tenesa, A, additional, Davies, G, additional, Lopez, L M, additional, Hansell, N K, additional, Medland, S E, additional, Ferrucci, L, additional, Schlessinger, D, additional, Montgomery, G W, additional, Wright, M J, additional, Aulchenko, Y S, additional, Janssens, A C J W, additional, Oostra, B A, additional, Metspalu, A, additional, Abecasis, G R, additional, Deary, I J, additional, Räikkönen, K, additional, Bierut, L J, additional, Martin, N G, additional, van Duijn, C M, additional, and Boomsma, D I, additional

Published
2010
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218. Autosomal recessive early onset Parkinsonism is linked to three loci: PARK2, PARK6 and PARK7

Author

Bonifati, Vincenzo, Dekker, M. C. J., Vanacore, Nicola, Fabbrini, Giovanni, Squitieri, F., Marconi, R., Antonini, A., Brustenghi, P., DALLA LIBERA, A., DE MARI, M., Stocchi, F., Montagna, P., Gallai, V., Rizzu, P., VAN SWIETEN, J. C., Oostra, B., VAN DUIJN, C. M., Meco, Giuseppe, Heutink, P., THE ITALIAN PARKINSON GENETICS NETWORK, Clinical Genetics, Epidemiology, and Neurology

Subjects
Parkinson's disease, Genotype, Ubiquitin-Protein Ligases, Locus (genetics), Dermatology, Consanguinity, Biology, Parkin, Ligases, Parkinsonian Disorders, medicine, Humans, Age of Onset, Gene, Genetics, Genetic heterogeneity, PARK7, General Medicine, medicine.disease, Pedigree, nervous system diseases, Psychiatry and Mental health, Phenotype, Mutation, Neurology (clinical), Age of onset
Abstract

Autosomal recessive, early onset parkinsonism (AREP) is genetically heterogeneous. Mutations in the parkin gene (PARK2 locus, chromosome 6q) account for up to 50% of AREP families. The parkin protein displays ubiquitin-ligase activity for different targets, which accumulate in the brain of patients with parkin defect and might cause neurodegeneration. Two new AREP loci (PARK6 and PARK7) have been recently mapped on chromosome 1p and confirmed in independent datasets, suggesting that both might be frequent. The three AREP forms display similar clinical phenotypes. Recruiting new families will help cloning the defective genes at PARK6 and PARK7 loci. This will contribute to unraveling the pathogenesis of AREP, and it is also expected to foster our understanding of molecular events underlying classic Parkinson's disease.

Published
2002

219. Genetic architecture of open angle glaucoma and related determinants

Author

Ramdas, W. D., primary, Amin, N., additional, van Koolwijk, L. M. E., additional, Janssens, A. C. J. W., additional, Demirkan, A., additional, de Jong, P. T. V. M., additional, Aulchenko, Y. S., additional, Wolfs, R. C. W., additional, Hofman, A., additional, Rivadeneira, F., additional, Uitterlinden, A. G., additional, Oostra, B. A., additional, Lemij, H. G., additional, Klaver, C. C. W., additional, Vingerling, J. R., additional, Jansonius, N. M., additional, and van Duijn, C. M., additional

Published
2010
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220. Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population

Author

Schuur, M., primary, van Swieten, J. C., additional, Schol-Gelok, S., additional, Ikram, M. A., additional, Vernooij, M. W., additional, Liu, F., additional, Isaacs, A., additional, de Boer, R., additional, de Koning, I., additional, Niessen, W. J., additional, Vrooman, H., additional, Oostra, B. A., additional, van der Lugt, A., additional, Breteler, M. M. B., additional, and van Duijn, C. M., additional

Published
2010
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221. Genome-wide association analysis identifies multiple loci related to resting heart rate

Author

Eijgelsheim, M., primary, Newton-Cheh, C., additional, Sotoodehnia, N., additional, de Bakker, P. I. W., additional, Muller, M., additional, Morrison, A. C., additional, Smith, A. V., additional, Isaacs, A., additional, Sanna, S., additional, Dorr, M., additional, Navarro, P., additional, Fuchsberger, C., additional, Nolte, I. M., additional, de Geus, E. J. C., additional, Estrada, K., additional, Hwang, S.-J., additional, Bis, J. C., additional, Ruckert, I.-M., additional, Alonso, A., additional, Launer, L. J., additional, Hottenga, J. J., additional, Rivadeneira, F., additional, Noseworthy, P. A., additional, Rice, K. M., additional, Perz, S., additional, Arking, D. E., additional, Spector, T. D., additional, Kors, J. A., additional, Aulchenko, Y. S., additional, Tarasov, K. V., additional, Homuth, G., additional, Wild, S. H., additional, Marroni, F., additional, Gieger, C., additional, Licht, C. M., additional, Prineas, R. J., additional, Hofman, A., additional, Rotter, J. I., additional, Hicks, A. A., additional, Ernst, F., additional, Najjar, S. S., additional, Wright, A. F., additional, Peters, A., additional, Fox, E. R., additional, Oostra, B. A., additional, Kroemer, H. K., additional, Couper, D., additional, Volzke, H., additional, Campbell, H., additional, Meitinger, T., additional, Uda, M., additional, Witteman, J. C. M., additional, Psaty, B. M., additional, Wichmann, H.-E., additional, Harris, T. B., additional, Kaab, S., additional, Siscovick, D. S., additional, Jamshidi, Y., additional, Uitterlinden, A. G., additional, Folsom, A. R., additional, Larson, M. G., additional, Wilson, J. F., additional, Penninx, B. W., additional, Snieder, H., additional, Pramstaller, P. P., additional, van Duijn, C. M., additional, Lakatta, E. G., additional, Felix, S. B., additional, Gudnason, V., additional, Pfeufer, A., additional, Heckbert, S. R., additional, Stricker, B. H. C., additional, Boerwinkle, E., additional, and O'Donnell, C. J., additional

Published
2010
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222. Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Author

Demirkan, A, primary, Penninx, B W J H, additional, Hek, K, additional, Wray, N R, additional, Amin, N, additional, Aulchenko, Y S, additional, van Dyck, R, additional, de Geus, E J C, additional, Hofman, A, additional, Uitterlinden, A G, additional, Hottenga, J-J, additional, Nolen, W A, additional, Oostra, B A, additional, Sullivan, P F, additional, Willemsen, G, additional, Zitman, F G, additional, Tiemeier, H, additional, Janssens, A C J W, additional, Boomsma, D I, additional, van Duijn, C M, additional, and Middeldorp, C M, additional

Published
2010
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224. Shared genetic factors in migraine and depression: Evidence from a genetic isolate

Author

Stam, A. H., primary, de Vries, B., additional, Janssens, A. C.J.W., additional, Vanmolkot, K.R.J., additional, Aulchenko, Y. S., additional, Henneman, P., additional, Oostra, B. A., additional, Frants, R. R., additional, van den Maagdenberg, A. M.J.M., additional, Ferrari, M. D., additional, van Duijn, C. M., additional, and Terwindt, G. M., additional

Published
2010
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225. European lactase persistence genotype shows evidence of association with increase in body mass index

Author

Kettunen, J., primary, Silander, K., additional, Saarela, O., additional, Amin, N., additional, Muller, M., additional, Timpson, N., additional, Surakka, I., additional, Ripatti, S., additional, Laitinen, J., additional, Hartikainen, A.-L., additional, Pouta, A., additional, Lahermo, P., additional, Anttila, V., additional, Mannisto, S., additional, Jula, A., additional, Virtamo, J., additional, Salomaa, V., additional, Lehtimaki, T., additional, Raitakari, O., additional, Gieger, C., additional, Wichmann, E. H., additional, Van Duijn, C. M., additional, Smith, G. D., additional, McCarthy, M. I., additional, Jarvelin, M.-R., additional, Perola, M., additional, and Peltonen, L., additional

Published
2009
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227. Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins

Author

Kollerits, B., primary, Coassin, S., additional, Beckmann, N. D., additional, Teumer, A., additional, Kiechl, S., additional, Doring, A., additional, Kavousi, M., additional, Hunt, S. C., additional, Lamina, C., additional, Paulweber, B., additional, Kutalik, Z., additional, Nauck, M., additional, van Duijn, C. M., additional, Heid, I. M., additional, Willeit, J., additional, Brandstatter, A., additional, Adams, T. D., additional, Mooser, V., additional, Aulchenko, Y. S., additional, Volzke, H., additional, and Kronenberg, F., additional

Published
2009
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229. Genome-wide association meta-analysis for total serum bilirubin levels

Author

Johnson, A. D., primary, Kavousi, M., additional, Smith, A. V., additional, Chen, M.-H., additional, Dehghan, A., additional, Aspelund, T., additional, Lin, J.-P., additional, van Duijn, C. M., additional, Harris, T. B., additional, Cupples, L. A., additional, Uitterlinden, A. G., additional, Launer, L., additional, Hofman, A., additional, Rivadeneira, F., additional, Stricker, B., additional, Yang, Q., additional, O'Donnell, C. J., additional, Gudnason, V., additional, and Witteman, J. C., additional

Published
2009
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230. Genome-wide association scan for five major dimensions of personality

Author

Terracciano, A, primary, Sanna, S, additional, Uda, M, additional, Deiana, B, additional, Usala, G, additional, Busonero, F, additional, Maschio, A, additional, Scally, M, additional, Patriciu, N, additional, Chen, W-M, additional, Distel, M A, additional, Slagboom, E P, additional, Boomsma, D I, additional, Villafuerte, S, additional, Śliwerska, E, additional, Burmeister, M, additional, Amin, N, additional, Janssens, A C J W, additional, van Duijn, C M, additional, Schlessinger, D, additional, Abecasis, G R, additional, and Costa, P T, additional

Published
2008
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235. Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide

Author

van Driel, L. M.J.W., primary, Smedts, H. P.M., additional, Helbing, W. A., additional, Isaacs, A., additional, Lindemans, J., additional, Uitterlinden, A. G., additional, van Duijn, C. M., additional, de Vries, J. H.M., additional, Steegers, E. A.P., additional, and Steegers-Theunissen, R. P.M., additional

Published
2008
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236. Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Gastric Cancer Risk: A Huge-GSEC Review

Author

Boccia, S., primary, Hung, R., additional, Ricciardi, G., additional, Gianfagna, F., additional, Ebert, M. P. A., additional, Fang, J.-Y., additional, Gao, C.-M., additional, Gotze, T., additional, Graziano, F., additional, Lacasana-Navarro, M., additional, Lin, D., additional, Lopez-Carrillo, L., additional, Qiao, Y.-L., additional, Shen, H., additional, Stolzenberg-Solomon, R., additional, Takezaki, T., additional, Weng, Y.-R., additional, Zhang, F. F., additional, van Duijn, C. M., additional, Boffetta, P., additional, and Taioli, E., additional

Published
2007
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243. CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease

Author

Sanchez-Juan, P., primary, Green, A., additional, Ladogana, A., additional, Cuadrado-Corrales, N., additional, Saanchez-Valle, R., additional, Mitrovaa, E., additional, Stoeck, K., additional, Sklaviadis, T., additional, Kulczycki, J., additional, Hess, K., additional, Bodemer, M., additional, Slivarichova, D., additional, Saiz, A., additional, Calero, M., additional, Ingrosso, L., additional, Knight, R., additional, Janssens, A. C.J.W., additional, van Duijn, C. M., additional, and Zerr, I., additional

Published
2006
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