Search

Your search keyword '"Duchateau P"' showing total 1,232 results
Start Over Author "Duchateau P"
1,232 results on '"Duchateau P"'

201. Tuning the Adhesive Strength of Functionalized Polyolefin-Based Hot Melt Adhesives: Unexpected Results Leading to New Opportunities

Author

Kruszynski, Jakub, Nowicka, Weronika, Pasha, Farhan Ahmad, Yang, Lanti, Rozanski, Artur, Bouyahyi, Miloud, Kleppinger, Ralf, Jasinska-Walc, Lidia, and Duchateau, Rob

Abstract

The development of lightweight, often multicomponent products requires adaptable and robust bonding solutions. Hot melt adhesives increasingly attract industrial interest as they combine good adhesive strength, facile processability, and cost-efficiency. Recently, our group has reported on the remarkable adhesive performance of hydroxyl-functionalized propylene-based copolymers in bonding both polar and nonpolar surfaces. The obtained adhesive strength proved to be too high for applications such as single-use packaging, which requires low to moderate adhesion for easy opening. Tuning the adhesive strength by manufacturing numerous functionalized polyolefin grades with varying contents of hydroxyl-functional groups is challenging in view of industrial-scale production. Herein, we elucidate an alternative approach to tune the adhesive performance by blending the functionalized propylene copolymers with nonfunctionalized congeners. To understand the structure–property relationship of the investigated diluted blends, a thorough characterization of morphology, physical properties, crystallization, and viscoelastic behavior was performed. It appeared that the crystallinity of the nonfunctionalized polyolefin and its miscibility with the functionalized polyolefin play a crucial role on the adhesive strength of the blends. Either a gradual decrease in adhesive strength with dilution was noticed or─surprisingly─no loss of adhesive strength was observed at all, not even after diluting 100 times! Molecular dynamics simulations revealed an intrinsic tendency of the hydroxyl-functionalized polyolefin to migrate to and interact with the aluminum oxide surface.

Published
2025
Full Text
View/download PDF

215. Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial

Author

Thomas, Akshay S, Duchateau, Luc, Kozma-Wiebe, Petra, and Jaffe, Glenn

Abstract

Background/aimsTo describe the clinical impact of external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption and subretinal fluid (SRF) seen on optical coherence tomography (OCT) in eyes with vitreomacular traction (VMT) without macular hole (MH) in the Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole study.MethodsPhase 3b randomised double-blind sham-controlled multicentre study including 144 eyes with VMT without MH. Eyes were randomised to receive a single intravitreal injection of ocriplasmin or sham injection and were followed for 24 months. Eyes were analysed for presence, course and clinical impact of ELM disruption, EZ disruption and SRF on OCT.ResultsELM disruption, EZ disruption and SRF were present in 32.6%, 52.2% and 45.8% of ocriplasmin-treated eyes and 39.6%, 42.6% and 37.5% of sham-treated eyes at baseline. VMT resolution was associated with resolution of ELM and EZ disruption and SRF. A small number of eyes had persistent ELM disruption, EZ disruption and/or SRF at the seventh visit or later (17 months or later) following medical or surgical VMT resolution. Resolution of ELM disruption, EZ disruption and/or SRF was associated with an improvement of visual acuity from baseline. Following VMT resolution, ELM recovery usually preceded EZ recovery and SRF resolution.ConclusionsELM disruption, EZ disruption and/or SRF are present in a significant percentage of eyes with VMT without MH. Release of VMT is usually associated with outer retinal recovery and an associated improvement in visual acuity. ELM recovery typically precedes EZ recovery and SRF resolution following VMT release.

Published
2023
Full Text
View/download PDF

216. Large-scale production of a therapeutic protein in transgenic tobacco plants: effect of subcellular targeting on quality of a recombinant dog gastric lipase

Author

Gruber, Véronique, Berna, Patrick P., Arnaud, Thierry, Bournat, Philippe, Clément, Christèle, Mison, Dominique, Olagnier, Béatrice, Philippe, Laurence, Theisen, Manfred, Baudino, Sylvie, Bénicourt, Claude, Cudrey, Claire, Bloës, Carole, Duchateau, Nathalie, Dufour, Sylvie, Gueguen, Catherine, Jacquet, Séverine, Ollivo, Catherine, Poncetta, Christine, Zorn, Nathalie, Ludevid, Dolores, Van Dorsselaer, Alain, Verger, Robert, Doherty, Annette, Mérot, Bertrand, and Danzin, Charles

Published
2001
Full Text
View/download PDF

228. Sinus node exit, crista terminalis conduction, interatrial connection, and wavefront collision: Key features of human atrial activation in sinus rhythm.

Author

Pambrun, Thomas, Derval, Nicolas, Duchateau, Josselin, Ramirez, F. Daniel, Chauvel, Rémi, Tixier, Romain, Marchand, Hugo, Bouyer, Benjamin, Welte, Nicolas, André, Clémentine, Nakashima, Takashi, Nakatani, Yosuke, Kamakura, Tsukasa, Takagi, Takamitsu, Krisai, Philipp, Ascione, Ciro, Balbo, Conrado, Cheniti, Ghassen, Vlachos, Konstantinos, and Bourier, Félix

Abstract

Background: An understanding of normal atrial activation during sinus rhythm can inform catheter ablation strategies to avoid deleterious impacts of ablation lesions on atrial conduction and mechanics.Objective: The purpose of this study was to describe how the sinus node impulse originates, propagates, and collides in right and left atria with normal voltage.Methods: Fifty consecutive patients undergoing catheter ablation of atrial fibrillation with endocardial atrial voltage >0.5 mV during high-density 3-dimensional mapping were studied.Results: Sinus node exits varied among patients along a lateral oblique arc extending from the anterior aspect of the superior vena cava (SVC) to the mid-posterior wall of the right atrium (RA). Conduction slowing or block at one of the smooth components that faces the crista terminalis was observed in 54% of cases, including complete block at the SVC musculature and systemic venous sinus in 6% of cases. Depending on these 2 key features of RA activation, interatrial conduction was mediated by the Bachmann bundle (64%) and posterior bundles (54%), with an overlap of the resulting left atrial breakthrough location. Wavefront collision was consistently observed at 3 sites: the septal aspect of the cavotricuspid isthmus, and the lower aspects of the dome and of the mitral isthmus.Conclusion: During sinus rhythm, atrial activation occurs via distinct sequences mediated by a complex interaction of anatomic factors. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

230. Integrating vulnerability analysis into the early stage distributed naval ship system design process

Author

van Diessen, M. F., Duchateau, E. A. E., Kana, A. A., and Hopman, J. J.

Abstract

ABSTRACTVulnerability reduction measures are taken during the early stage distributed ship system design process to ensure the availability of the required systems in a damaged state. Traditionally these vulnerability reduction measures are based on design rules or best practices resulting from past experiences. Therefore, the measures are not per definition applicable for future warships, as both the system concepts and operational environment changes. Recently developed vulnerability assessment methods are able to determine the vulnerability of a design early in the design process. With the integration of these methods in the early stage design process, the results of the analysis can be used to generate less vulnerable distributed ship system designs. This paper proposes an integral and holistic approach to optimisation of the design variables and distributed networks as these are becoming increasingly interdependent. The result of this approach is a model which generates distributed ship system designs consisting of component positions, a topology and routed connections based on a pre-defined system configuration and constraining physical architecture. Five testcases were conducted using this model, showing the necessity of the integral and holistic approach as the extent to which the contemporary design rules are implemented depends on the network complexity and operational environment.

Published
2022
Full Text
View/download PDF

236. PO-05-109 ELECTROPHYSIOLOGICAL CHARACTERISTICS AND DURABILITY OF INDEX PFA LESIONS FROM REDO PROCEDURES FOR ATRIAL ARRHYTHMIA RECURRENCES.

Author

Yokoyama, Masaaki, Vlachos, Konstantinos G., Ascione, Ciro, Kowalewski, Christopher, Monaco, Cinzia, Spittler, Raphael, Kneizeh, Kinan, Benali, Karim, Popa, Miruna A., Moussaoui, Nadir, Arnaud, Marine, BULIARD, Samuel, Bouyer, Benjamin, Chauvel, Rémi, TIXIER, Romain, Duchateau, Josselin, Pambrun, Thomas, DERVAL, NICOLAS, Cochet, Hubert, and HOCINI, Mélèze

Published
2024
Full Text
View/download PDF

243. Effect of electrode size and spacing on electrograms: Optimized electrode configuration for near-field electrogram characterization.

Author

Takigawa, Masateru, Kitamura, Takeshi, Basu, Shubhayu, Bartal, Meir, Martin, Claire A., Martin, Ruairidh, Cheniti, Ghassen, Vlachos, Konstantinos, Pillois, Xavier, Frontera, Antonio, Massoullié, Grégoire, Thompson, Nathaniel, Bourier, Felix, Lam, Anna, Duchateau, Josselin, Pambrun, Thomas, Denis, Arnaud, Derval, Nicolas, Cochet, Hubert, and Haïssaguerre, Michel

Abstract

Background: Detailed effects of electrode size on electrograms (EGMs) have not been systematically examined.Objectives: We aimed to elucidate the effect of electrode size on EGMs and investigate an optimal configuration of electrode size and interelectrode spacing for gap detection and far-field reduction.Methods: This study included 8 sheep in which probes with different electrode size and interelectrode spacing were epicardially placed on healthy, fatty, and lesion tissues for measurements. Between 3 electrode sizes (0.1 mm/0.2 mm/0.5 mm) with 3 mm spacing. As indices of capability in gap detection and far-field reduction, in different electrode sizes (0.1 mm/0.2 mm/0.5 mm) and interelectrode spacing (0.1 mm/0.2 mm/0.3 mm/0.5 mm/3 mm) and the optimized electrode size and interelectrode spacing were determined. Compared between PentaRay and the optimal probe determined in study 2.Results: Study 1 demonstrated that unipolar voltage and the duration of EGMs increased as the electrode size increased in any tissue (P < .001). Bipolar EGMs had the same tendency in healthy/fat tissues, but not in lesions. Study 2 showed that significantly higher gap to lesion volume ratio and healthy to fat tissue voltage ratio were provided by a smaller electrode (0.2 mm or 0.3 mm electrode) and smaller spacing (0.1 mm spacing), but 0.3 mm electrode/0.1 mm spacing provided a larger bipolar voltage (P < .05). Study 3 demonstrated that 0.3 mm electrode/0.1 mm spacing provided less deflection with more discrete EGMs (P < .0001) with longer and more reproducible AF cycle length (P < .0001) compared to PentaRay.Conclusion: Electrode size affects both unipolar and bipolar EGMs. Catheters with microelectrodes and very small interelectrode spacing may be superior in gap detection and far-field reduction. Importantly, this electrode configuration could dramatically reduce artifactual complex fractionated atrial electrograms and may open a new era for AF mapping. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

244. Optimized two‐step electroporation process to achieve efficient nonviral‐mediated gene insertion into primary T cells.

Author

Yang, Ming, Tkach, Diane, Boyne, Alex, Kazancioglu, Selena, Duclert, Aymeric, Poirot, Laurent, Duchateau, Philippe, and Juillerat, Alexandre

Subjects
ELECTROPORATION, T cells, CHIMERIC antigen receptors, GENE delivery techniques, GENOME editing, GENETIC vectors, GENES, DNA repair
Abstract

The development of gene editing technologies over the past years has allowed the precise and efficient insertion of transgenes into the genome of various cell types. Knock‐in approaches using homology‐directed repair and designer nucleases often rely on viral vectors, which can considerably impact the manufacturing cost and timeline of gene‐edited therapeutic products. An attractive alternative would be to use naked DNA as a repair template. However, such a strategy faces challenges such as cytotoxicity from double‐stranded DNA (dsDNA) to primary cells. Here, we sought to study the kinetics of transcription activator‐like effector nuclease (TALEN)‐mediated gene editing in primary T cells to improve nonviral gene knock‐in. Harnessing this knowledge, we developed a rapid and efficient gene insertion strategy based on either short single‐stranded oligonucleotides or large (2 Kb) linear naked dsDNA sequences. We demonstrated that a time‐controlled two‐step transfection protocol can substantially improve the efficiency of nonviral transgene integration in primary T cells. Using this approach, we achieved modification of up to ˜ 30% of T cells when inserting a chimeric antigen receptor (CAR) at the T‐cell receptor alpha constant region (TRAC) locus to generate 'off‐the shelf' CAR‐T cells. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results